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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ME2-NARS (FusionGDB2 ID:52153)

Fusion Gene Summary for ME2-NARS

Fusion gene summary

Fusion gene information	Fusion gene name: ME2-NARS
	Fusion gene ID: 52153
		Hgene	Tgene
	Gene symbol	ME2	NARS
	Gene ID	56125	4677
	Gene name	protocadherin beta 11	asparaginyl-tRNA synthetase 1
	Synonyms	ME2\|PCDH-BETA11	ASNRS\|NARS
	Cytomap	5q31.3	18q21.31
	Type of gene	protein-coding	protein-coding
	Description	protocadherin beta-11PCDH-beta-11cadherin ME2	asparagine--tRNA ligase, cytoplasmicasparagine tRNA ligase 1, cytoplasmicasparaginyl-tRNA synthetase, cytoplasmic
	Modification date	20200313	20200313
	UniProtAcc	.	Q96I59
	Ensembl transtripts involved in fusion gene	ENST00000321341, ENST00000382927, ENST00000585680,	ENST00000256854, ENST00000423481,
Fusion gene scores	* DoF score	5 X 3 X 5=75	8 X 9 X 3=216
	# samples	5	9
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ME2 [Title/Abstract] AND NARS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ME2(48443878)-NARS(55283207), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NARS	GO:0006421	asparaginyl-tRNA aminoacylation	9421509
Tgene	NARS	GO:0016477	cell migration	9421509

Fusion gene breakpoints across ME2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NARS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-14-0736-02A	ME2	chr18	48443878	+	NARS	chr18	55283207	-

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Fusion Gene ORF analysis for ME2-NARS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000321341	ENST00000256854	ME2	chr18	48443878	+	NARS	chr18	55283207	-
5CDS-5UTR	ENST00000321341	ENST00000423481	ME2	chr18	48443878	+	NARS	chr18	55283207	-
In-frame	ENST00000382927	ENST00000256854	ME2	chr18	48443878	+	NARS	chr18	55283207	-
5CDS-5UTR	ENST00000382927	ENST00000423481	ME2	chr18	48443878	+	NARS	chr18	55283207	-
intron-3CDS	ENST00000585680	ENST00000256854	ME2	chr18	48443878	+	NARS	chr18	55283207	-
intron-5UTR	ENST00000585680	ENST00000423481	ME2	chr18	48443878	+	NARS	chr18	55283207	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000321341

ME2

chr18

48443878

ENST00000256854

NARS

chr18

55283207

3452

902

257

2455

732

ENST00000382927

ME2

chr18

48443878

ENST00000256854

NARS

chr18

55283207

3381

831

186

2384

732

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000321341	ENST00000256854	ME2	chr18	48443878	+	NARS	chr18	55283207	-	0.00045458	0.9995454
ENST00000382927	ENST00000256854	ME2	chr18	48443878	+	NARS	chr18	55283207	-	0.000445544	0.99955446

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Fusion Genomic Features for ME2-NARS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ME2-NARS

Go to
FGviewer for the breakpoints of chr18:48443878-chr18:55283207
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NARS Q96I59
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ME2

chr18:48443878

chr18:55283207

ENST00000321341

165_173

210.0

585.0

Nucleotide binding

NAD

Hgene

ME2

chr18:48443878

chr18:55283207

ENST00000382927

165_173

210.0

480.0

Nucleotide binding

NAD

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ME2

chr18:48443878

chr18:55283207

ENST00000321341

311_328

210.0

585.0

Nucleotide binding

NAD

Hgene

ME2

chr18:48443878

chr18:55283207

ENST00000382927

311_328

210.0

480.0

Nucleotide binding

NAD

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Fusion Gene Sequence for ME2-NARS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000321341_ENST00000256854_TCGA-14-0736-02A_ME2_chr18_48443878_+_NARS_chr18_55283207_length(transcript)=3452nt_BP=902nt
CCCGTCCGTCTCCACCGTGGGCCACGCCTTCCGGGCCCCGCGGCTGGCCGGCTCCTCGCGCCCTCCCCTCTCTCGGCCGCTCTTCGGGCC
GCCTCTGCGTGTGGGGCCGCCCGCGCCAGTGTGAGCCTGAGCTGACGGCGGCTCCGGGAGGCTCGCAGAAGGGGAGGGCCGGGCGGCGCG
GGAGCTGAGCATCGCCAGGGCGGGCGGCAGGGCGCGGCCTCTCCGCCGGGTGTACCACCTGTCGCGGCGCGAGACCTCTGGTGAAAGAAA
AGATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCACATAAAAGAAAAAGGCAAGCCACTTATGC
TGAACCCAAGAACAAACAAGGGAATGGCATTTACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTCTACCTCCCAAAATAGAGA
CACAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAAAAATATATCTACATAATGGGAATACAAG
AAAGAAATGAGAAATTGTTTTATAGAATACTGCAAGATGACATTGAGAGTTTAATGCCAATTGTATATACACCGACGGTTGGTCTTGCCT
GCTCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGAGGTCATGTTAGATCAATTGTGGATAACT
GGCCAGAAAATCATGTTAAGGCTGTTGTAGTGACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGTGTCTATGGAATGGGAATTC
CAGTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCAGTGTGTATTGATGTGGGAACTGATAATA
TCGCTTTGATGACAGTAGGGAAAGAACCATTTCCTACCATTTACGTAGATTCACAAAAAGAAAATGAGAGGTGGAATGTTATTTCTAAAT
CACAGTTGAAGAACATTAAAAAGATGTGGCATAGGGAACAAATGAAGAGTGAATCCCGGGAAAAGAAAGAGGCAGAAGATAGTTTACGAA
GAGAAAAGAACCTGGAAGAAGCAAAGAAGATTACCATTAAAAATGATCCAAGTCTCCCAGAGCCAAAATGTGTGAAGATTGGTGCGTTAG
AAGGATATAGAGGCCAAAGAGTAAAGGTGTTTGGCTGGGTCCACAGGCTGCGCAGGCAAGGAAAGAATTTAATGTTTCTGGTGTTGCGAG
ATGGTACAGGTTATCTTCAGTGTGTCTTGGCGGATGAGTTGTGTCAGTGCTACAATGGAGTTCTCTTGTCCACGGAGAGCAGTGTTGCAG
TGTATGGAATGCTAAATCTTACCCCAAAGGGCAAGCAGGCTCCAGGTGGCCATGAGCTGAGTTGTGACTTCTGGGAACTAATTGGGTTGG
CCCCTGCTGGAGGAGCTGACAACCTGATCAATGAGGAGTCTGACGTTGATGTCCAGCTCAACAACAGACACATGATGATCCGAGGAGAAA
ACATGTCCAAAATCCTAAAAGCACGATCCATGGTCACCAGGTGCTTTAGAGATCACTTCTTTGATAGGGGGTACTATGAAGTTACTCCTC
CAACATTAGTGCAAACACAAGTAGAAGGTGGTGCCACACTCTTCAAGCTTGACTATTTTGGGGAAGAGGCATTTTTGACTCAATCCTCTC
AGTTGTACTTGGAGACCTGCCTCCCAGCCCTGGGAGATGTTTTTTGTATTGCTCAGTCATACCGGGCAGAGCAGTCCAGAACACGAAGGC
ACCTGGCTGAGTACACTCACGTGGAAGCTGAGTGTCCTTTCCTGACTTTTGACGACCTCCTGAACCGGTTGGAGGACTTGGTTTGTGATG
TGGTAGATCGAATATTGAAGTCACCTGCAGGGAGCATAGTGCATGAGCTCAACCCGAACTTTCAGCCCCCCAAACGGCCTTTCAAACGGA
TGAACTATTCAGATGCTATCGTTTGGCTAAAAGAACATGATGTAAAGAAAGAAGATGGAACTTTCTATGAATTTGGAGAAGATATCCCAG
AAGCTCCTGAGAGACTGATGACAGACACCATTAATGAACCAATCTTGCTGTGTCGATTTCCTGTGGAGATCAAGTCCTTCTACATGCAGC
GATGTCCTGAGGATTCCCGTCTTACTGAATCTGTCGACGTGTTGATGCCCAATGTTGGTGAGATTGTGGGAGGCTCAATGCGTATCTTTG
ATAGTGAAGAAATACTGGCAGGTTATAAAAGGGAAGGGATTGACCCCACTCCCTATTACTGGTATACGGATCAGAGAAAATACGGTACAT
GTCCCCATGGAGGATATGGCTTGGGCTTGGAACGATTCTTAACGTGGATTCTGAATAGGTATCACATCCGAGACGTGTGCTTATACCCTC
GATTTGTCCAGCGTTGCACGCCATAACCATTTTCTCCAGAAGCGTGGAGGAAAGATTATGAAAGGAACAGGCTCTTTAAAAAAGAAAACA
AAAAGCCAGAATCTTCCTTTTTTTGTTTCATTGGGGTTTCTCTTTCTGTTTTTCTTTCTACTACCATAAAAACTATCTCAAATCACCTGA
ACATCAAGTGATATTAAGGTTGTCATCTTAAGAAAAAATATCCATTTTTTTCTTAAGTTCGGGAAACAAAGTTCGGGGAAAATACCTGGC
ATGAAACTGTAGTTAGGGATACATTTCAGCATTTTACTCACTTTATCCAAGTTATTCATTTTATTCAAGTTATATGTATGTATAATTCAA
CAATTTTAGATTATGGTGTAAGATACTCCAGTAACTTATCTTTCTGTCCTTTTAAGTGTACCTTGAATTCTTTGATTTATTTTATTGCAT
CAATGAATTAAAACAAAAATCTTGGGGGAAGAAATTGGCAATATCGTATAAAAATCTGCTCATATTAGAACACAGTATAATTCAGCAGTA
AACACTAGAATCAAATGAATAGCCTTTTGTATCAGTTATTAATCTTTTCTAACTCTGCTTAGCTGCTAATAATCCTGAGGCATAGAAATT
GAAGAATTTGTAAAAATAGAATTGCCTTAAAGGATTTGAAGTAAGAACATAATTTTGGGGAGAGTTTTTTAGTGATTCACAGTATCCCTC
TTAGCATTAATTTAAGGTAAAGAGGCAGATTGATTTTCCCTCTTTCCTGGTAATTCCTAAGTAATTAAGAATAAATAAGTTCCAAAAGAA
ATTGTAGCTGGAATCTTAATAACAATTGTGAGTGGCTGTTTGAGTTGCCCCCACCATGTCCTTAGATCTAATCTGTGCTACCTTATTAAC
TCACAGCAGGCTTACTGAATGGCTTCATTTCAGATTTAGTTGATTTCTCCACCAAATGCATGTCATGTATTCTCAATAGGCTGTATTCCC

>In-frame_ENST00000321341_ENST00000256854_TCGA-14-0736-02A_ME2_chr18_48443878_+_NARS_chr18_55283207_length(amino acids)=732AA_start in transcript=257_stop in transcript=2455
MVKEKMLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYI
MGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVY
GMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALMTVGKEPFPTIYVDSQKENERWNVISKSQLKNIKKMWHREQMKSESREKKEAE
DSLRREKNLEEAKKITIKNDPSLPEPKCVKIGALEGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLADELCQCYNGVLLSTE
SSVAVYGMLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSMVTRCFRDHFFDRGYY
EVTPPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLNRLED
LVCDVVDRILKSPAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIPEAPERLMTDTINEPILLCRFPVEIKS
FYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIFDSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDV

--------------------------------------------------------------
>In-frame_ENST00000382927_ENST00000256854_TCGA-14-0736-02A_ME2_chr18_48443878_+_NARS_chr18_55283207_length(transcript)=3381nt_BP=831nt
CTCGGCCGCTCTTCGGGCCGCCTCTGCGTGTGGGGCCGCCCGCGCCAGTGTGAGCCTGAGCTGACGGCGGCTCCGGGAGGCTCGCAGAAG
GGGAGGGCCGGGCGGCGCGGGAGCTGAGCATCGCCAGGGCGGGCGGCAGGGCGCGGCCTCTCCGCCGGGTGTACCACCTGTCGCGGCGCG
AGACCTCTGGTGAAAGAAAAGATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCACATAAAAGAA
AAAGGCAAGCCACTTATGCTGAACCCAAGAACAAACAAGGGAATGGCATTTACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTT
CTACCTCCCAAAATAGAGACACAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAAAAATATATC
TACATAATGGGAATACAAGAAAGAAATGAGAAATTGTTTTATAGAATACTGCAAGATGACATTGAGAGTTTAATGCCAATTGTATATACA
CCGACGGTTGGTCTTGCCTGCTCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGAGGTCATGTT
AGATCAATTGTGGATAACTGGCCAGAAAATCATGTTAAGGCTGTTGTAGTGACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGT
GTCTATGGAATGGGAATTCCAGTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCAGTGTGTATT
GATGTGGGAACTGATAATATCGCTTTGATGACAGTAGGGAAAGAACCATTTCCTACCATTTACGTAGATTCACAAAAAGAAAATGAGAGG
TGGAATGTTATTTCTAAATCACAGTTGAAGAACATTAAAAAGATGTGGCATAGGGAACAAATGAAGAGTGAATCCCGGGAAAAGAAAGAG
GCAGAAGATAGTTTACGAAGAGAAAAGAACCTGGAAGAAGCAAAGAAGATTACCATTAAAAATGATCCAAGTCTCCCAGAGCCAAAATGT
GTGAAGATTGGTGCGTTAGAAGGATATAGAGGCCAAAGAGTAAAGGTGTTTGGCTGGGTCCACAGGCTGCGCAGGCAAGGAAAGAATTTA
ATGTTTCTGGTGTTGCGAGATGGTACAGGTTATCTTCAGTGTGTCTTGGCGGATGAGTTGTGTCAGTGCTACAATGGAGTTCTCTTGTCC
ACGGAGAGCAGTGTTGCAGTGTATGGAATGCTAAATCTTACCCCAAAGGGCAAGCAGGCTCCAGGTGGCCATGAGCTGAGTTGTGACTTC
TGGGAACTAATTGGGTTGGCCCCTGCTGGAGGAGCTGACAACCTGATCAATGAGGAGTCTGACGTTGATGTCCAGCTCAACAACAGACAC
ATGATGATCCGAGGAGAAAACATGTCCAAAATCCTAAAAGCACGATCCATGGTCACCAGGTGCTTTAGAGATCACTTCTTTGATAGGGGG
TACTATGAAGTTACTCCTCCAACATTAGTGCAAACACAAGTAGAAGGTGGTGCCACACTCTTCAAGCTTGACTATTTTGGGGAAGAGGCA
TTTTTGACTCAATCCTCTCAGTTGTACTTGGAGACCTGCCTCCCAGCCCTGGGAGATGTTTTTTGTATTGCTCAGTCATACCGGGCAGAG
CAGTCCAGAACACGAAGGCACCTGGCTGAGTACACTCACGTGGAAGCTGAGTGTCCTTTCCTGACTTTTGACGACCTCCTGAACCGGTTG
GAGGACTTGGTTTGTGATGTGGTAGATCGAATATTGAAGTCACCTGCAGGGAGCATAGTGCATGAGCTCAACCCGAACTTTCAGCCCCCC
AAACGGCCTTTCAAACGGATGAACTATTCAGATGCTATCGTTTGGCTAAAAGAACATGATGTAAAGAAAGAAGATGGAACTTTCTATGAA
TTTGGAGAAGATATCCCAGAAGCTCCTGAGAGACTGATGACAGACACCATTAATGAACCAATCTTGCTGTGTCGATTTCCTGTGGAGATC
AAGTCCTTCTACATGCAGCGATGTCCTGAGGATTCCCGTCTTACTGAATCTGTCGACGTGTTGATGCCCAATGTTGGTGAGATTGTGGGA
GGCTCAATGCGTATCTTTGATAGTGAAGAAATACTGGCAGGTTATAAAAGGGAAGGGATTGACCCCACTCCCTATTACTGGTATACGGAT
CAGAGAAAATACGGTACATGTCCCCATGGAGGATATGGCTTGGGCTTGGAACGATTCTTAACGTGGATTCTGAATAGGTATCACATCCGA
GACGTGTGCTTATACCCTCGATTTGTCCAGCGTTGCACGCCATAACCATTTTCTCCAGAAGCGTGGAGGAAAGATTATGAAAGGAACAGG
CTCTTTAAAAAAGAAAACAAAAAGCCAGAATCTTCCTTTTTTTGTTTCATTGGGGTTTCTCTTTCTGTTTTTCTTTCTACTACCATAAAA
ACTATCTCAAATCACCTGAACATCAAGTGATATTAAGGTTGTCATCTTAAGAAAAAATATCCATTTTTTTCTTAAGTTCGGGAAACAAAG
TTCGGGGAAAATACCTGGCATGAAACTGTAGTTAGGGATACATTTCAGCATTTTACTCACTTTATCCAAGTTATTCATTTTATTCAAGTT
ATATGTATGTATAATTCAACAATTTTAGATTATGGTGTAAGATACTCCAGTAACTTATCTTTCTGTCCTTTTAAGTGTACCTTGAATTCT
TTGATTTATTTTATTGCATCAATGAATTAAAACAAAAATCTTGGGGGAAGAAATTGGCAATATCGTATAAAAATCTGCTCATATTAGAAC
ACAGTATAATTCAGCAGTAAACACTAGAATCAAATGAATAGCCTTTTGTATCAGTTATTAATCTTTTCTAACTCTGCTTAGCTGCTAATA
ATCCTGAGGCATAGAAATTGAAGAATTTGTAAAAATAGAATTGCCTTAAAGGATTTGAAGTAAGAACATAATTTTGGGGAGAGTTTTTTA
GTGATTCACAGTATCCCTCTTAGCATTAATTTAAGGTAAAGAGGCAGATTGATTTTCCCTCTTTCCTGGTAATTCCTAAGTAATTAAGAA
TAAATAAGTTCCAAAAGAAATTGTAGCTGGAATCTTAATAACAATTGTGAGTGGCTGTTTGAGTTGCCCCCACCATGTCCTTAGATCTAA
TCTGTGCTACCTTATTAACTCACAGCAGGCTTACTGAATGGCTTCATTTCAGATTTAGTTGATTTCTCCACCAAATGCATGTCATGTATT

>In-frame_ENST00000382927_ENST00000256854_TCGA-14-0736-02A_ME2_chr18_48443878_+_NARS_chr18_55283207_length(amino acids)=732AA_start in transcript=186_stop in transcript=2384
MVKEKMLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYI
MGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVY
GMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALMTVGKEPFPTIYVDSQKENERWNVISKSQLKNIKKMWHREQMKSESREKKEAE
DSLRREKNLEEAKKITIKNDPSLPEPKCVKIGALEGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLADELCQCYNGVLLSTE
SSVAVYGMLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSMVTRCFRDHFFDRGYY
EVTPPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLNRLED
LVCDVVDRILKSPAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIPEAPERLMTDTINEPILLCRFPVEIKS
FYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIFDSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ME2-NARS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ME2-NARS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	NARS	Q96I59	DB00174	Asparagine		Small molecule	Approved\|Investigational\|Nutraceutical

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Related Diseases for ME2-NARS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ME2	C0005586	Bipolar Disorder	1	PSYGENET
Hgene	ME2	C0024713	Manic Disorder	1	PSYGENET
Hgene	ME2	C0033975	Psychotic Disorders	1	PSYGENET
Hgene	ME2	C0036341	Schizophrenia	1	PSYGENET
Hgene	ME2	C0338831	Manic	1	PSYGENET
Hgene	ME2	C0349204	Nonorganic psychosis	1	PSYGENET