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Fusion gene:MECOM-SEC62 (FusionGDB2 ID:52200) |
Fusion Gene Summary for MECOM-SEC62 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MECOM-SEC62 | Fusion gene ID: 52200 | Hgene | Tgene | Gene symbol | MECOM | SEC62 | Gene ID | 2122 | 7095 |
Gene name | MDS1 and EVI1 complex locus | SEC62 homolog, preprotein translocation factor | |
Synonyms | AML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2 | Dtrp1|HTP1|TLOC1|TP-1 | |
Cytomap | 3q26.2 | 3q26.2 | |
Type of gene | protein-coding | protein-coding | |
Description | histone-lysine N-methyltransferase MECOMAML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein EVI1MDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein | translocation protein SEC62SEC62 preprotein translocation factorhTP-1membrane protein SEC62, S.cerevisiae, homolog oftranslocation protein 1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q03112 | . | |
Ensembl transtripts involved in fusion gene | ENST00000264674, ENST00000392736, ENST00000464456, ENST00000472280, ENST00000494292, ENST00000468789, ENST00000460814, ENST00000433243, ENST00000485957, | ENST00000337002, ENST00000480708, ENST00000470355, | |
Fusion gene scores | * DoF score | 33 X 21 X 11=7623 | 17 X 20 X 8=2720 |
# samples | 43 | 25 | |
** MAII score | log2(43/7623*10)=-4.14795031118505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(25/2720*10)=-3.44360665147561 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MECOM [Title/Abstract] AND SEC62 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MECOM(169098975)-SEC62(169693396), # samples:1 SEC62(169706147)-MECOM(169099312), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MECOM | GO:0045892 | negative regulation of transcription, DNA-templated | 10856240|11568182 |
Hgene | MECOM | GO:0045893 | positive regulation of transcription, DNA-templated | 11568182|19767769 |
Hgene | MECOM | GO:0051726 | regulation of cell cycle | 11568182 |
Fusion gene breakpoints across MECOM (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across SEC62 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-HU-A4GH-01A | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
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Fusion Gene ORF analysis for MECOM-SEC62 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000264674 | ENST00000337002 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000264674 | ENST00000480708 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-intron | ENST00000264674 | ENST00000470355 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000392736 | ENST00000337002 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000392736 | ENST00000480708 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-intron | ENST00000392736 | ENST00000470355 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000464456 | ENST00000337002 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000464456 | ENST00000480708 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-intron | ENST00000464456 | ENST00000470355 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000472280 | ENST00000337002 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000472280 | ENST00000480708 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-intron | ENST00000472280 | ENST00000470355 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
In-frame | ENST00000494292 | ENST00000337002 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
In-frame | ENST00000494292 | ENST00000480708 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
5CDS-intron | ENST00000494292 | ENST00000470355 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000468789 | ENST00000337002 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000468789 | ENST00000480708 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-intron | ENST00000468789 | ENST00000470355 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000460814 | ENST00000337002 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000460814 | ENST00000480708 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-intron | ENST00000460814 | ENST00000470355 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000433243 | ENST00000337002 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-3CDS | ENST00000433243 | ENST00000480708 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
intron-intron | ENST00000433243 | ENST00000470355 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
5UTR-3CDS | ENST00000485957 | ENST00000337002 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
5UTR-3CDS | ENST00000485957 | ENST00000480708 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
5UTR-intron | ENST00000485957 | ENST00000470355 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000494292 | MECOM | chr3 | 169098975 | - | ENST00000337002 | SEC62 | chr3 | 169693396 | + | 6947 | 473 | 98 | 1636 | 512 |
ENST00000494292 | MECOM | chr3 | 169098975 | - | ENST00000480708 | SEC62 | chr3 | 169693396 | + | 1852 | 473 | 98 | 1636 | 512 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000494292 | ENST00000337002 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + | 0.000311957 | 0.999688 |
ENST00000494292 | ENST00000480708 | MECOM | chr3 | 169098975 | - | SEC62 | chr3 | 169693396 | + | 0.002294721 | 0.9977053 |
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Fusion Genomic Features for MECOM-SEC62 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MECOM-SEC62 |
Go to FGviewer for the breakpoints of chr3:169098975-chr3:169693396 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MECOM | . |
FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | SEC62 | chr3:169098975 | chr3:169693396 | ENST00000337002 | 0 | 8 | 218_234 | 12.0 | 400.0 | Topological domain | Lumenal | |
Tgene | SEC62 | chr3:169098975 | chr3:169693396 | ENST00000337002 | 0 | 8 | 256_399 | 12.0 | 400.0 | Topological domain | Cytoplasmic | |
Tgene | SEC62 | chr3:169098975 | chr3:169693396 | ENST00000480708 | 0 | 9 | 218_234 | 12.0 | 442.0 | Topological domain | Lumenal | |
Tgene | SEC62 | chr3:169098975 | chr3:169693396 | ENST00000480708 | 0 | 9 | 256_399 | 12.0 | 442.0 | Topological domain | Cytoplasmic | |
Tgene | SEC62 | chr3:169098975 | chr3:169693396 | ENST00000337002 | 0 | 8 | 197_217 | 12.0 | 400.0 | Transmembrane | Helical | |
Tgene | SEC62 | chr3:169098975 | chr3:169693396 | ENST00000337002 | 0 | 8 | 235_255 | 12.0 | 400.0 | Transmembrane | Helical | |
Tgene | SEC62 | chr3:169098975 | chr3:169693396 | ENST00000480708 | 0 | 9 | 197_217 | 12.0 | 442.0 | Transmembrane | Helical | |
Tgene | SEC62 | chr3:169098975 | chr3:169693396 | ENST00000480708 | 0 | 9 | 235_255 | 12.0 | 442.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 1065_1116 | 0 | 1117.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 1065_1116 | 0 | 1052.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 1065_1116 | 0 | 1053.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 1065_1116 | 0 | 1043.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 1065_1116 | 0 | 1052.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 1065_1116 | 0 | 1053.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 78_190 | 0 | 1117.0 | Domain | SET |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 78_190 | 0 | 1052.0 | Domain | SET |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 78_190 | 0 | 1053.0 | Domain | SET |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 78_190 | 0 | 1043.0 | Domain | SET |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 78_190 | 0 | 1052.0 | Domain | SET |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 78_190 | 0 | 1053.0 | Domain | SET |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 609_622 | 0 | 1117.0 | Motif | Nuclear localization signal |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 741_745 | 0 | 1117.0 | Motif | CTBP-binding motif 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 772_776 | 0 | 1117.0 | Motif | CTBP-binding motif 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 609_622 | 0 | 1052.0 | Motif | Nuclear localization signal |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 741_745 | 0 | 1052.0 | Motif | CTBP-binding motif 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 772_776 | 0 | 1052.0 | Motif | CTBP-binding motif 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 609_622 | 0 | 1053.0 | Motif | Nuclear localization signal |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 741_745 | 0 | 1053.0 | Motif | CTBP-binding motif 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 772_776 | 0 | 1053.0 | Motif | CTBP-binding motif 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 609_622 | 0 | 1043.0 | Motif | Nuclear localization signal |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 741_745 | 0 | 1043.0 | Motif | CTBP-binding motif 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 772_776 | 0 | 1043.0 | Motif | CTBP-binding motif 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 609_622 | 0 | 1052.0 | Motif | Nuclear localization signal |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 741_745 | 0 | 1052.0 | Motif | CTBP-binding motif 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 772_776 | 0 | 1052.0 | Motif | CTBP-binding motif 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 609_622 | 0 | 1053.0 | Motif | Nuclear localization signal |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 741_745 | 0 | 1053.0 | Motif | CTBP-binding motif 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 772_776 | 0 | 1053.0 | Motif | CTBP-binding motif 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 209_236 | 0 | 1117.0 | Zinc finger | C2H2-type 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 263_285 | 0 | 1117.0 | Zinc finger | C2H2-type 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 291_313 | 0 | 1117.0 | Zinc finger | C2H2-type 3 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 319_342 | 0 | 1117.0 | Zinc finger | C2H2-type 4 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 348_370 | 0 | 1117.0 | Zinc finger | C2H2-type 5 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 376_398 | 0 | 1117.0 | Zinc finger | C2H2-type 6 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 405_427 | 0 | 1117.0 | Zinc finger | C2H2-type 7%3B atypical |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 912_934 | 0 | 1117.0 | Zinc finger | C2H2-type 8 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 940_963 | 0 | 1117.0 | Zinc finger | C2H2-type 9 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 969_991 | 0 | 1117.0 | Zinc finger | C2H2-type 10 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 209_236 | 0 | 1052.0 | Zinc finger | C2H2-type 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 263_285 | 0 | 1052.0 | Zinc finger | C2H2-type 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 291_313 | 0 | 1052.0 | Zinc finger | C2H2-type 3 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 319_342 | 0 | 1052.0 | Zinc finger | C2H2-type 4 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 348_370 | 0 | 1052.0 | Zinc finger | C2H2-type 5 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 376_398 | 0 | 1052.0 | Zinc finger | C2H2-type 6 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 405_427 | 0 | 1052.0 | Zinc finger | C2H2-type 7%3B atypical |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 912_934 | 0 | 1052.0 | Zinc finger | C2H2-type 8 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 940_963 | 0 | 1052.0 | Zinc finger | C2H2-type 9 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 969_991 | 0 | 1052.0 | Zinc finger | C2H2-type 10 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 209_236 | 0 | 1053.0 | Zinc finger | C2H2-type 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 263_285 | 0 | 1053.0 | Zinc finger | C2H2-type 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 291_313 | 0 | 1053.0 | Zinc finger | C2H2-type 3 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 319_342 | 0 | 1053.0 | Zinc finger | C2H2-type 4 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 348_370 | 0 | 1053.0 | Zinc finger | C2H2-type 5 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 376_398 | 0 | 1053.0 | Zinc finger | C2H2-type 6 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 405_427 | 0 | 1053.0 | Zinc finger | C2H2-type 7%3B atypical |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 912_934 | 0 | 1053.0 | Zinc finger | C2H2-type 8 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 940_963 | 0 | 1053.0 | Zinc finger | C2H2-type 9 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 969_991 | 0 | 1053.0 | Zinc finger | C2H2-type 10 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 209_236 | 0 | 1043.0 | Zinc finger | C2H2-type 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 263_285 | 0 | 1043.0 | Zinc finger | C2H2-type 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 291_313 | 0 | 1043.0 | Zinc finger | C2H2-type 3 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 319_342 | 0 | 1043.0 | Zinc finger | C2H2-type 4 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 348_370 | 0 | 1043.0 | Zinc finger | C2H2-type 5 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 376_398 | 0 | 1043.0 | Zinc finger | C2H2-type 6 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 405_427 | 0 | 1043.0 | Zinc finger | C2H2-type 7%3B atypical |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 912_934 | 0 | 1043.0 | Zinc finger | C2H2-type 8 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 940_963 | 0 | 1043.0 | Zinc finger | C2H2-type 9 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 969_991 | 0 | 1043.0 | Zinc finger | C2H2-type 10 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 209_236 | 0 | 1052.0 | Zinc finger | C2H2-type 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 263_285 | 0 | 1052.0 | Zinc finger | C2H2-type 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 291_313 | 0 | 1052.0 | Zinc finger | C2H2-type 3 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 319_342 | 0 | 1052.0 | Zinc finger | C2H2-type 4 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 348_370 | 0 | 1052.0 | Zinc finger | C2H2-type 5 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 376_398 | 0 | 1052.0 | Zinc finger | C2H2-type 6 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 405_427 | 0 | 1052.0 | Zinc finger | C2H2-type 7%3B atypical |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 912_934 | 0 | 1052.0 | Zinc finger | C2H2-type 8 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 940_963 | 0 | 1052.0 | Zinc finger | C2H2-type 9 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 969_991 | 0 | 1052.0 | Zinc finger | C2H2-type 10 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 209_236 | 0 | 1053.0 | Zinc finger | C2H2-type 1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 263_285 | 0 | 1053.0 | Zinc finger | C2H2-type 2 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 291_313 | 0 | 1053.0 | Zinc finger | C2H2-type 3 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 319_342 | 0 | 1053.0 | Zinc finger | C2H2-type 4 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 348_370 | 0 | 1053.0 | Zinc finger | C2H2-type 5 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 376_398 | 0 | 1053.0 | Zinc finger | C2H2-type 6 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 405_427 | 0 | 1053.0 | Zinc finger | C2H2-type 7%3B atypical |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 912_934 | 0 | 1053.0 | Zinc finger | C2H2-type 8 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 940_963 | 0 | 1053.0 | Zinc finger | C2H2-type 9 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 969_991 | 0 | 1053.0 | Zinc finger | C2H2-type 10 |
Tgene | SEC62 | chr3:169098975 | chr3:169693396 | ENST00000337002 | 0 | 8 | 1_196 | 12.0 | 400.0 | Topological domain | Cytoplasmic | |
Tgene | SEC62 | chr3:169098975 | chr3:169693396 | ENST00000480708 | 0 | 9 | 1_196 | 12.0 | 442.0 | Topological domain | Cytoplasmic |
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Fusion Gene Sequence for MECOM-SEC62 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000494292_ENST00000337002_TCGA-HU-A4GH-01A_MECOM_chr3_169098975_-_SEC62_chr3_169693396_length(transcript)=6947nt_BP=473nt AGAGAGAGGGAGGGAGCGAGAGGGAGAGCAAAAGAAGGAAAGGATCCAAGAAAAAAAAGCCCCAACCACACACCAGCGGCTGCAGGACTG GGCACAGCATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAATAATGAGTGTGTATATGGCAACTACCCTGAAATACCTTTGGAAG AAATGCCAGATGCAGATGGAGTAGCCAGCACTCCCTCCCTCAATATTCAAGAGCCATGCTCTCCTGCCACATCCAGTGAAGCATTCACTC CAAAGGAGGGTTCTCCTTACAAAGCCCCCATCTACATCCCTGATGATATCCCCATTCCTGCTGAGTTTGAACTTCGAGAGTCAAATATGC CTGGGGCAGGACTAGGAATATGGACCAAAAGGAAGATCGAAGTAGGTGAAAAGTTTGGGCCTTATGTGGGAGAGCAGAGGTCAAACCTGA AAGACCCCAGTTATGGATGGGAGGAAGTTGGTGAACCATCTAAAGAAGAGAAGGCTGTGGCCAAGTATCTTCGATTCAACTGTCCAACAA AGTCCACCAATATGATGGGTCACCGGGTTGATTATTTTATTGCTTCAAAAGCAGTGGACTGTCTTTTGGATTCAAAGTGGGCAAAGGCCA AGAAAGGAGAGGAAGCTTTATTTACAACCAGGGAGTCTGTGGTTGACTACTGCAACAGGCTTTTAAAGAAGCAGTTTTTTCACCGAGCCC TAAAAGTAATGAAAATGAAATATGATAAAGACATAAAGAAAGAAAAAGATAAAGGAAAAGCTGAAAGTGGAAAAGAAGAAGATAAAAAGA GCAAGAAAGAAAATATAAAGGATGAGAAGACAAAAAAAGAAAAAGAGAAAAAAAAAGATGGTGAAAAGGAAGAATCCAAAAAGGAGGAAA CTCCAGGAACTCCTAAAAAGAAGGAAACTAAGAAAAAATTCAAACTTGAGCCACATGATGATCAGGTTTTTCTGGATGGAAATGAGGTGT ATGTATGGATCTATGACCCAGTTCACTTTAAAACATTTGTCATGGGATTAATTCTTGTGATTGCAGTAATAGCGGCCACCCTCTTCCCCC TTTGGCCAGCAGAAATGAGAGTAGGTGTTTATTACCTCAGTGTGGGTGCAGGCTGTTTTGTAGCCAGTATTCTTCTCCTTGCTGTTGCTC GATGCATTCTATTTCTCATCATTTGGCTCATAACTGGAGGAAGGCACCACTTTTGGTTCTTGCCAAATCTGACTGCTGATGTGGGCTTCA TTGACTCCTTCAGGCCTCTGTACACACATGAATACAAAGGACCAAAAGCAGACTTAAAGAAAGATGAGAAGTCTGAAACCAAAAAGCAAC AGAAGTCCGACAGTGAGGAAAAGTCAGACAGTGAGAAAAAGGAAGATGAGGAGGGGAAAGTAGGACCAGGAAATCATGGAACAGAAGGCT CGGGGGGAGAACGGCATTCAGACACGGACAGTGACAGGAGGGAAGATGATCGATCCCAGCACAGTAGTGGAAATGGAAATGATTTTGAAA TGATAACAAAAGAGGAACTGGAACAGCAAACAGATGGGGATTGTGAAGAGGATGAGGAAGAGGAAAATGATGGAGAAACACCTAAATCTT CACATGAAAAATCATAATCTGACTAATTTTGGGACTGAATGAATAAGTACAAGAGGTTGGATTTTCTATGTTGGCTGATTACCATATTGA ACACATGGCATTTGTAGCATTCTTTAAATCTATCTACTGAAATGTATTTGACATTCAAGCAGTTATATTCGGTCCTTCATTTTATAGAAT ATTGGCACTATTATTGGTACAGTTTAAAGCCATTAATATGTTTTATCCATTTGATAATTTTACAGTAAGTAGGTCTCATTCATTTTGACA GTTATCAAAGATGTACTTTCCACAGTTAAATTTACATTAATGGCAATTTTTGATAGTTTTATGGCTTTTTACTGTTAGACTAATCAAAAA TAACTTTAAAAGGAACAAAGAAACTCCAACATTTCACATTATGCATAGTTATGTAGCCATTTCACAGTTTCTTTAAGATGTGTAAACTCA TTGTCCTTGATAGTTTTTATTTTTCATTATAAAATTATACCAGGAGATTTCTTTTAAGATTCTGAGTTAGCAGAGTTCAAAACTATTTTG TGGAAACAAGCCAACTAGTAACAATGCAGCAACACTTCTGGTTTAGCTAAATTATTTTTCCAATGTAGGAAATCCACACTGATTTGTACG TCTGACTGAGAGAAAGATGGTCGTCTCCAGCAGAGAAAGTGAACAGCATTTGTTGGAAGGTGATGGCTCTCCCTCCTCCCTCCCCATTTC ATTGGCGTAACGTAAAGTGTATTCTGTACATAATTTACAAATAAAACATTTTATTTTAATTGTTACTTATTATTTAGATATTTCTCAACA CTTAAATTCATAAAATTAAGACCATGTAAGGGTATGTTTTTAGAGAAATGGAAGTTTGAGTAACCCACAGAACATCTGTGATCTTTCTAC AGCAGCTTCAGTTTTGTGCCAACATTCCATGTATTTTGAATATGAGCAAAAACTGATCTTAAGAGCAGACTTAAAGTAGCTTTGTACGCC TTAATGTTCATTTTGATTTATTTTAAATCTTTACATTCAGAAATGAGATACTGTATTATCAGACCAGGAGGCATTGCTGTGAAAGATAAT TTCCTATTCTAAAATATCAAATTTAAAATAAAGATAATGAAAGAAAACATAAGAGAACTATTGGACTCTAATTGCTTTGAACTAGTTTTG CAGTTTGACTTTACGTCTTATACATCTTAGTTACAAGTCTTTGGAAACTCTTGTTTACTTATGAGCATAATCATTCCTTGGAGTTATACT AACTAATAATGAATATTAAATGATTTTTCTTCAGTCACAGTGAGAGCATCTTGCTTTGTGGTTGAAATAGGTAGTGTATGTCAGTCTTTG CTTTAGGCTGTTTCTCATCTAAGTGTTTGAATTAAAGATGTTAAATTTTTCTAATTGTGAAAAATATGTTTTCTGTATCGACACATTTTA TTAAACTTGGCTTGATTGCTTCTTTATAGTAGTCCCTGTAAGTGGACATAAATGTGGCTATTTGATGTTAATGCAACTATGTCAAGGCTG CAATCACTTTAATAGTTTCTTTTTAGCAAATAAATGTTCATTGATGAAGTGCCTGGGTATTTTCCCGTCCCATTTGCAGAGCTCTACTAC TTCATTTCCACAGTAAGCATATATATAATGATCACTTCTGAGTTTATCACCAGTAACATTGATACCTATTTTGGGGTATAAACATGGTGT TTTTCAGAAATAAAAATTATTTCATTAACCTTTACTATTACTGTGATAATACCCAGGCACTCAATATTCATCCTGAAATTTTTTATAATA TATGTAATTTGTCTAGTCTTAAAGACATTTGGAGCATGGCCAACAGGAAGGTCAGCTTCTTACTGATGTGTGTGGATTCTTACAGAATGT TAGTACAAATTTTTATAAATATTTGGTGATCCCTGGGGGGAAATATCATTCTTACTATGGTTAGAAAGTGAATTAGAAATTTCAGCTCAG TTTCTATTTTACTATTCAAGTTGTGTACTTTAAACAAATATAAAAATCAAAAGGCTGCCTCTATTACAATCCTCAGTGGAATAGATGGCT ATCTTTCTTGGCTAACATTAAATATTCTTGTACCAGAGCATGGAAAATCGTTTATAATTGTTAATAGAATGGCGATTTTTTTTTAAGAAC TTCAGATTTGCTATGCTGCTGTAAGTAGAAAGCATGAAGCTTTTTGATCATGTAGGGCTTATTGTAGAGGGTATCAATTGGCCTAACTAA GCAGGATTGAATTTACCAGAGGCTAAGTTCAGATAGTAAGAATAATGCATATGTGATTGTTCTTAAAGTCAATGTATTAAATAAGGTATT TTTCCTTTTCCCTCTTACTGGATTTTTCAATTTTCAAACCATATGGCCTAGGTAACTTTAATTGAAATAATATAGATTTAGTTGAATACT ATTCAGGAAGTAATAAATTTTAATATATCACATTGAAATTATGCAGTGGTGATGAATTTTGGTGTTTCCCCCCTCTTTCTGGTTTTACAT CATGAGGATCAGTTAGCTGCTGACAAGAAAAGTCATCTTGTGTCTTTTGTAAATTGAATTTTTTTTTTAAATCTATTAGGAACTGGAAAA CAGCAAGTATGGTTGATTCTCATTATTCAAGGTAGTTACGTTCTATAAAGTCACTGCGAACACTGAATTAGCAAATATAGAACCTAGGGG AAATACAAGGCTAGATTTCTGCAAGCCACTGGTCACATTTTCATCAAGCAGTCAACATGTAAATTTCTGTTGTAAAGACACCTTATTTAA TATAATCGATTCATTAACATTGAAGTCATGACCAACAACACTGTAACTCATGCCTGAATGAAGCTTATCTGACACATAAGCTTCATAAGG CACACAACAGCCTTTTTACCCTTAGGAACAGCTTTTTGCCCTTAGCACTATGCTTGGGGGCCATTTTAAACAGTGAAATCAAAAAAAGAA CAGAAATGCAAAAACCATGGCATTAGCGTAAAAAGGACACGTTTATAGTATGAAAGCTGGAACATGGCCTTGTTCAACCTCAGCTCAGAA TATGTGTACAGCAAGTTTTTTGCTGTACCACAAAATTTTAGGTTAGGCAAATTCACAAATACGGAATCCATGAATAACGAGGATCAACTG TACTTAACTATATTTTAAAGCTGTGACATTTATCTACCTGGTTTATGGAATAGAATTTATTGCTGAATCATGCTCCAGTATTTGAGTGAT GTTTTAAATATCCTATGTCTGAAAATAATTCCTCCTAATTGTGTGGTAATTTGCTTTTACTGTTTCCACAGTATTTCAGGTCTTTGCTCA TTCACTCAGTAATACTGAGCACTTACCATGTACCAGAATTTTACTAGGCACAACCATGAATAAAAATACAATTCTCTTGCACCATTAAAT AGTGTGTTAAGTGCTACGGCAGCAAATTGCTACATGTGCTGGATATCTCTTGTTTTCCCCTCCAGCTCCACTCTGCTCTTGCCCACAAAG CTGACCCGAATGGACCACAGCAGTGGGCTCCTATGCCTCCTGGCTTCTGAGTGGGTTTGGCCAAGGAGTGTCCTGGCCAGAGATCAGAGG ATGGTAGGGTGCCTATTCTCGGCTCTTCTCCTGGGGTTGGGGGGCTGCCTTAGCAGCCAAAGGTCACTTCTCCCAAACTCCTTCCCTGCT TTCCAGGTTGCCAGTCCCTGCACTCTTCCTTTCTGGCCAAGGATGATGTCAGTTCTGCTGCTACTAGCCTGGAGTTGCAGAAGCTACTGT GCTTCCTCTTTGGGTAGCCTATACCTATACTTATCTCCTCATAATATCTTCATGTAAAGAACCATCTGTTTCTTATTGGAATCAAGACCA ATACCAAGGAGAAATTCCTAGGGAACAAAAATTCCAATGAGGAATTGACCTCTTTGTCAGATCCTTATCACCAAACATTAGAAAAGATCT CATAACTTTATACAGCATGTTGTAAGCATTTTGATAACTAAAATCCTGTTCTAGTGAATGTCATGCAGATAACTACACAAGGAGATTAAT TTAAATTTGCCTTCTTTGGCAAGCCCTTAAACCAATGGCTAAAGCAGTTAGTTGTGAGTTTCTGAGTAGGTCCCAATGCGTTTATTTCAT TTGTCCAACCTAGCACAGAGATCCTTTGATACTTTAATTGCATGGCTTTTCCAATCAGACGAAATTTCAGTCTGAGAGAGGACATATTTT CTGAGGTTTATAGTTTTAGGATTGTCCAAAAGGCCTATGATCTCTTCTTAGCATGACAGAAAGAGGGAAAGATAAGTTAAATTTCAAGGG GGTCATATCATCACACTTTGGTCTTATTTCATTTTCAATGATTTCCTAGATCACTTTAACTTTTTTGTGTCATGGACTCCTCAGAATAAT GGGTTTTTTTTGTTTGTTTGTTTGTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGAAATCTCAGCTCACTGCAA CCTCCGCCTCCTGAGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACATGCCACCACACCCAGCTAATTT TTGTATTTTTTAGTAGAGACAGGGTTTCACCGTGTTGGCGAGACTGATCTTGAACTCCTGACATCAGGTGATCCACCTGCCTCGGCCTCC CAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCTGGCCAGAATAATGTTTTTAAATGCAGAAAAGGAAATGCATGGGGTTACAAGGG AAACGAATTACACTGAAGTGTAAGCTACCAAATAATTTATGATGTGGTAGTTATAGGTGTGCATTTAATAGCCAGATCTACGAGTGGATG TAATAACTGCTATGATGTTGAAGTAGCATAAAACATATATTAGATATCTGCAACAACTGTGATGTAACATGAAAATACCTGATTTCTGTT GACAAAGTTACTGCTAGTACAACTGTGGATTGTTGTCTGCACTCGTCATTGAAGGAAATACTAAATTTTAGTTTTAGGCTAGTGAAATTA AAGTTAATTTTTCCCATCCAAGTTCATGTATCTTCTGAATTCTATCCGTGAATCCCTTAGAGGTCTGTGAATTGTAGGTTAAGAACCCCT GCCCTAGCTAATCAGATCCACCAATGTTTCAAATAGGACTATAACTTATTCAAAGGCCAATGATACTTCGCATAATTCAATTTTAATATT ATTCACATTTCATGTCACAAATTTAGTAAGTTACATGTGTTATGTGATGTTTTGTTTTGATAGATTATATCTTACTCCTAAATAAAAAGT >In-frame_ENST00000494292_ENST00000337002_TCGA-HU-A4GH-01A_MECOM_chr3_169098975_-_SEC62_chr3_169693396_length(amino acids)=512AA_start in transcript=98_stop in transcript=1636 MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVDCLLDSKWAKAKKG EEALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKAESGKEEDKKSKKENIKDEKTKKEKEKKKDGEKEESKKEETPG TPKKKETKKKFKLEPHDDQVFLDGNEVYVWIYDPVHFKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAVARCI LFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKVGPGNHGTEGSGG -------------------------------------------------------------- >In-frame_ENST00000494292_ENST00000480708_TCGA-HU-A4GH-01A_MECOM_chr3_169098975_-_SEC62_chr3_169693396_length(transcript)=1852nt_BP=473nt AGAGAGAGGGAGGGAGCGAGAGGGAGAGCAAAAGAAGGAAAGGATCCAAGAAAAAAAAGCCCCAACCACACACCAGCGGCTGCAGGACTG GGCACAGCATGAGATCCAAAGGCAGGGCAAGGAAACTGGCCACAAATAATGAGTGTGTATATGGCAACTACCCTGAAATACCTTTGGAAG AAATGCCAGATGCAGATGGAGTAGCCAGCACTCCCTCCCTCAATATTCAAGAGCCATGCTCTCCTGCCACATCCAGTGAAGCATTCACTC CAAAGGAGGGTTCTCCTTACAAAGCCCCCATCTACATCCCTGATGATATCCCCATTCCTGCTGAGTTTGAACTTCGAGAGTCAAATATGC CTGGGGCAGGACTAGGAATATGGACCAAAAGGAAGATCGAAGTAGGTGAAAAGTTTGGGCCTTATGTGGGAGAGCAGAGGTCAAACCTGA AAGACCCCAGTTATGGATGGGAGGAAGTTGGTGAACCATCTAAAGAAGAGAAGGCTGTGGCCAAGTATCTTCGATTCAACTGTCCAACAA AGTCCACCAATATGATGGGTCACCGGGTTGATTATTTTATTGCTTCAAAAGCAGTGGACTGTCTTTTGGATTCAAAGTGGGCAAAGGCCA AGAAAGGAGAGGAAGCTTTATTTACAACCAGGGAGTCTGTGGTTGACTACTGCAACAGGCTTTTAAAGAAGCAGTTTTTTCACCGAGCCC TAAAAGTAATGAAAATGAAATATGATAAAGACATAAAGAAAGAAAAAGATAAAGGAAAAGCTGAAAGTGGAAAAGAAGAAGATAAAAAGA GCAAGAAAGAAAATATAAAGGATGAGAAGACAAAAAAAGAAAAAGAGAAAAAAAAAGATGGTGAAAAGGAAGAATCCAAAAAGGAGGAAA CTCCAGGAACTCCTAAAAAGAAGGAAACTAAGAAAAAATTCAAACTTGAGCCACATGATGATCAGGTTTTTCTGGATGGAAATGAGGTGT ATGTATGGATCTATGACCCAGTTCACTTTAAAACATTTGTCATGGGATTAATTCTTGTGATTGCAGTAATAGCGGCCACCCTCTTCCCCC TTTGGCCAGCAGAAATGAGAGTAGGTGTTTATTACCTCAGTGTGGGTGCAGGCTGTTTTGTAGCCAGTATTCTTCTCCTTGCTGTTGCTC GATGCATTCTATTTCTCATCATTTGGCTCATAACTGGAGGAAGGCACCACTTTTGGTTCTTGCCAAATCTGACTGCTGATGTGGGCTTCA TTGACTCCTTCAGGCCTCTGTACACACATGAATACAAAGGACCAAAAGCAGACTTAAAGAAAGATGAGAAGTCTGAAACCAAAAAGCAAC AGAAGTCCGACAGTGAGGAAAAGTCAGACAGTGAGAAAAAGGAAGATGAGGAGGGGAAAGTAGGACCAGGAAATCATGGAACAGAAGGCT CGGGGGGAGAACGGCATTCAGACACGGACAGTGACAGGAGGGAAGATGATCGATCCCAGCACAGTAGTGGAAATGGAAATGATTTTGAAA TGATAACAAAAGAGGAACTGGAACAGCAAACAGATGGGGATTGTGAAGAGGATGAGGAAGAGGAAAATGATGGAGAAACACCTAAATCTT CACATGAAAAATCATAATCTGACTAATTTTGGGACTGAATGAATAAGTACAAGAGGAAATCCACACTGATTTGTACGTCTGACTGAGAGA AAGATGGTCGTCTCCAGCAGAGAAAGTGAACAGCATTTGTTGGAAGGTGATGGCTCTCCCTCCTCCCTCCCCATTTCATTGGCGTAACGT >In-frame_ENST00000494292_ENST00000480708_TCGA-HU-A4GH-01A_MECOM_chr3_169098975_-_SEC62_chr3_169693396_length(amino acids)=512AA_start in transcript=98_stop in transcript=1636 MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGA GLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVDCLLDSKWAKAKKG EEALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKAESGKEEDKKSKKENIKDEKTKKEKEKKKDGEKEESKKEETPG TPKKKETKKKFKLEPHDDQVFLDGNEVYVWIYDPVHFKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAVARCI LFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKVGPGNHGTEGSGG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MECOM-SEC62 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000264674 | - | 1 | 17 | 189_440 | 0 | 1117.0 | MAPK9%2C SMAD3 and probably SUV39H1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000392736 | - | 1 | 16 | 189_440 | 0 | 1052.0 | MAPK9%2C SMAD3 and probably SUV39H1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000433243 | - | 1 | 17 | 189_440 | 0 | 1053.0 | MAPK9%2C SMAD3 and probably SUV39H1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000464456 | - | 1 | 15 | 189_440 | 0 | 1043.0 | MAPK9%2C SMAD3 and probably SUV39H1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000468789 | - | 1 | 16 | 189_440 | 0 | 1052.0 | MAPK9%2C SMAD3 and probably SUV39H1 |
Hgene | MECOM | chr3:169098975 | chr3:169693396 | ENST00000472280 | - | 1 | 16 | 189_440 | 0 | 1053.0 | MAPK9%2C SMAD3 and probably SUV39H1 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MECOM-SEC62 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MECOM-SEC62 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MECOM | C4225221 | RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 2 | 3 | GENOMICS_ENGLAND;UNIPROT |
Hgene | MECOM | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
Hgene | MECOM | C0007102 | Malignant tumor of colon | 1 | CTD_human |
Hgene | MECOM | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | MECOM | C0023448 | Lymphoid leukemia | 1 | CTD_human |
Hgene | MECOM | C0023466 | Leukemia, Monocytic, Chronic | 1 | CTD_human |
Hgene | MECOM | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | MECOM | C0023470 | Myeloid Leukemia | 1 | CTD_human |
Hgene | MECOM | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
Hgene | MECOM | C0027022 | Myeloproliferative disease | 1 | CTD_human |
Hgene | MECOM | C0027439 | Nasopharyngeal Neoplasms | 1 | CTD_human |
Hgene | MECOM | C0030312 | Pancytopenia | 1 | CTD_human |
Hgene | MECOM | C0038002 | Splenomegaly | 1 | CTD_human |
Hgene | MECOM | C0238301 | Cancer of Nasopharynx | 1 | CTD_human |
Hgene | MECOM | C0678222 | Breast Carcinoma | 1 | CTD_human |
Hgene | MECOM | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | MECOM | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
Hgene | MECOM | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
Hgene | MECOM | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | MECOM | C1854273 | Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia | 1 | GENOMICS_ENGLAND;ORPHANET |
Hgene | MECOM | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
Hgene | MECOM | C2931456 | Prostate cancer, familial | 1 | CTD_human |
Hgene | MECOM | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
Hgene | MECOM | C4722327 | PROSTATE CANCER, HEREDITARY, 1 | 1 | CTD_human |