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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED23-ANO2 (FusionGDB2 ID:52383)

Fusion Gene Summary for MED23-ANO2

check button Fusion gene summary
Fusion gene informationFusion gene name: MED23-ANO2
Fusion gene ID: 52383
HgeneTgene
Gene symbol

MED23

ANO2

Gene ID

9439

57101

Gene namemediator complex subunit 23anoctamin 2
SynonymsARC130|CRSP130|CRSP133|CRSP3|DRIP130|MRT18|SUR-2|SUR2C12orf3|TMEM16B
Cytomap

6q23.2

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 23130 kDa transcriptional co-activator133 kDa transcriptional co-activatoractivator-recruited cofactor 130 kDa componentcofactor required for Sp1 transcriptional activation subunit 3mental retardatianoctamin-2anoctamin 2, calcium activated chloride channeltransmembrane protein 16B (eight membrane-spanning domains)
Modification date2020031320200329
UniProtAcc

Q9ULK4

Q9NQ90

Ensembl transtripts involved in fusion geneENST00000354577, ENST00000403834, 
ENST00000368068, ENST00000479213, 
ENST00000368060, ENST00000368058, 
ENST00000545957, ENST00000368053, 
ENST00000540546, ENST00000539158, 
ENST00000327087, ENST00000546188, 
ENST00000356134, ENST00000538154, 
Fusion gene scores* DoF score6 X 8 X 4=19212 X 11 X 8=1056
# samples 915
** MAII scorelog2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1056*10)=-2.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED23 [Title/Abstract] AND ANO2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED23(131908849)-ANO2(5841796), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED23

GO:0006355

regulation of transcription, DNA-templated

9989412


check buttonFusion gene breakpoints across MED23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ANO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-Q1-A5R2-01AMED23chr6

131908849

-ANO2chr12

5841796

-
ChimerDB4CESCTCGA-Q1-A5R2-01AMED23chr6

131908849

-ANO2chr12

5841796

-
ChimerDB4CESCTCGA-Q1-A5R2-01AMED23chr6

131908849

-ANO2chr12

5841796

-


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Fusion Gene ORF analysis for MED23-ANO2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000354577ENST00000327087MED23chr6

131908849

-ANO2chr12

5841796

-
In-frameENST00000354577ENST00000546188MED23chr6

131908849

-ANO2chr12

5841796

-
In-frameENST00000354577ENST00000356134MED23chr6

131908849

-ANO2chr12

5841796

-
5CDS-5UTRENST00000354577ENST00000538154MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000403834ENST00000327087MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000403834ENST00000546188MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000403834ENST00000356134MED23chr6

131908849

-ANO2chr12

5841796

-
intron-5UTRENST00000403834ENST00000538154MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000368068ENST00000327087MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000368068ENST00000546188MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000368068ENST00000356134MED23chr6

131908849

-ANO2chr12

5841796

-
intron-5UTRENST00000368068ENST00000538154MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000479213ENST00000327087MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000479213ENST00000546188MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000479213ENST00000356134MED23chr6

131908849

-ANO2chr12

5841796

-
intron-5UTRENST00000479213ENST00000538154MED23chr6

131908849

-ANO2chr12

5841796

-
In-frameENST00000368060ENST00000327087MED23chr6

131908849

-ANO2chr12

5841796

-
In-frameENST00000368060ENST00000546188MED23chr6

131908849

-ANO2chr12

5841796

-
In-frameENST00000368060ENST00000356134MED23chr6

131908849

-ANO2chr12

5841796

-
5CDS-5UTRENST00000368060ENST00000538154MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000368058ENST00000327087MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000368058ENST00000546188MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000368058ENST00000356134MED23chr6

131908849

-ANO2chr12

5841796

-
intron-5UTRENST00000368058ENST00000538154MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000545957ENST00000327087MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000545957ENST00000546188MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000545957ENST00000356134MED23chr6

131908849

-ANO2chr12

5841796

-
intron-5UTRENST00000545957ENST00000538154MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000368053ENST00000327087MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000368053ENST00000546188MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000368053ENST00000356134MED23chr6

131908849

-ANO2chr12

5841796

-
intron-5UTRENST00000368053ENST00000538154MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000540546ENST00000327087MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000540546ENST00000546188MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000540546ENST00000356134MED23chr6

131908849

-ANO2chr12

5841796

-
intron-5UTRENST00000540546ENST00000538154MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000539158ENST00000327087MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000539158ENST00000546188MED23chr6

131908849

-ANO2chr12

5841796

-
intron-3CDSENST00000539158ENST00000356134MED23chr6

131908849

-ANO2chr12

5841796

-
intron-5UTRENST00000539158ENST00000538154MED23chr6

131908849

-ANO2chr12

5841796

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354577MED23chr6131908849-ENST00000327087ANO2chr125841796-6462425115658131885
ENST00000354577MED23chr6131908849-ENST00000546188ANO2chr125841796-6459425115658131885
ENST00000354577MED23chr6131908849-ENST00000356134ANO2chr125841796-6459425115658131885
ENST00000368060MED23chr6131908849-ENST00000327087ANO2chr125841796-6468425718058191879
ENST00000368060MED23chr6131908849-ENST00000546188ANO2chr125841796-6465425718058191879
ENST00000368060MED23chr6131908849-ENST00000356134ANO2chr125841796-6465425718058191879

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354577ENST00000327087MED23chr6131908849-ANO2chr125841796-0.0003621220.99963784
ENST00000354577ENST00000546188MED23chr6131908849-ANO2chr125841796-0.0003613940.99963856
ENST00000354577ENST00000356134MED23chr6131908849-ANO2chr125841796-0.0003613940.99963856
ENST00000368060ENST00000327087MED23chr6131908849-ANO2chr125841796-0.0003562760.9996437
ENST00000368060ENST00000546188MED23chr6131908849-ANO2chr125841796-0.000355560.9996444
ENST00000368060ENST00000356134MED23chr6131908849-ANO2chr125841796-0.000355560.9996444

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Fusion Genomic Features for MED23-ANO2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED23-ANO2


check button Go to

FGviewer for the breakpoints of chr6:131908849-chr12:5841796

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED23

Q9ULK4

ANO2

Q9NQ90

FUNCTION: Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269|PubMed:10353252, ECO:0000269|PubMed:14759369, ECO:0000269|PubMed:16595664}.FUNCTION: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. {ECO:0000269|PubMed:19474308, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21890523, ECO:0000269|PubMed:21984732}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANO2chr6:131908849chr12:5841796ENST0000032708713261001_1003478.0999.0MotifNote=DLG4 binding (PDZ)
TgeneANO2chr6:131908849chr12:5841796ENST0000035613414271001_1003479.01000.0MotifNote=DLG4 binding (PDZ)
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326560_582478.0999.0Topological domainExtracellular
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326604_623478.0999.0Topological domainCytoplasmic
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326645_748478.0999.0Topological domainExtracellular
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326770_801478.0999.0Topological domainCytoplasmic
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326823_907478.0999.0Topological domainExtracellular
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326929_1003478.0999.0Topological domainCytoplasmic
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427560_582479.01000.0Topological domainExtracellular
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427604_623479.01000.0Topological domainCytoplasmic
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427645_748479.01000.0Topological domainExtracellular
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427770_801479.01000.0Topological domainCytoplasmic
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427823_907479.01000.0Topological domainExtracellular
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427929_1003479.01000.0Topological domainCytoplasmic
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326539_559478.0999.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326583_603478.0999.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326624_644478.0999.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326749_769478.0999.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326802_822478.0999.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326908_928478.0999.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427539_559479.01000.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427583_603479.01000.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427624_644479.01000.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427749_769479.01000.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427802_822479.01000.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427908_928479.01000.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANO2chr6:131908849chr12:5841796ENST0000032708713261_365478.0999.0Topological domainCytoplasmic
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326387_434478.0999.0Topological domainExtracellular
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326456_538478.0999.0Topological domainCytoplasmic
TgeneANO2chr6:131908849chr12:5841796ENST0000035613414271_365479.01000.0Topological domainCytoplasmic
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427387_434479.01000.0Topological domainExtracellular
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427456_538479.01000.0Topological domainCytoplasmic
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326366_386478.0999.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003270871326435_455478.0999.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427366_386479.01000.0TransmembraneHelical
TgeneANO2chr6:131908849chr12:5841796ENST000003561341427435_455479.01000.0TransmembraneHelical


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Fusion Gene Sequence for MED23-ANO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000354577_ENST00000327087_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(transcript)=6462nt_BP=4251nt
GAGGGAACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGAGGTCTCCGCCCCTCTGCCCCTATA
TTCCCAGAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAGATGGAGACGCAACTGCAGAGCATT
TTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCTGAAGATGAGAAAACAAAACTAATT
AGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATCCAGTGGATTGTTAAGTTTATTCAT
GGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGTCTCCTTCCACCCAGGCTGGTTTGT
GAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAACTGGTTCGGAAAATAATTGGGGGA
GTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAATACAGTGAGCTCTGCTGTTGTACAG
CAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCCTATTTTGCAGTCACTGAGATCAGG
AAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGATACCTTCAGGCCCACAGCAAGGATA
AACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCATGGAAACTGGATCCTGCTACTCTT
CGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGATCTGTTTGAACCACAGACTGCTTTGTTGAGATATGTATTGGAGCAGCCTTAT
TCCAGGGATATGGTCTGCAATATGCTAGGTTTAAATAAGCAGACCTTGAACATTGCTCAGCACAAGCAGCGCTGCCCTGTGCTGGAGGAC
CAGTTGGTGGATCTGGTTGTTTATGCCATGGAGCGATCTGAGACCGAGGAGAAGTTTGACGATGGGGGAACAAGCCAACTCCTGTGGCAG
CATCTCTCAAGTCAGCTCATTTTCTTTGTGCTTTTCCAGTTTGCAAGTTTTCCACATATGGTGCTTTCTCTTCATCAGAAGTTAGCAGGG
CGAGGACTGATTAAAGGCAGAGATCATCTTATGTGGGTTCTCCTGCAATTCATTTCTGGAAGTATTCAGAAAAATGCACTAGCTGATTTT
CTCCCTGTGATGAAGCTCTTCGACTTGCTATACCCAGAAAAAGAATATATCCCAGTTCCTGATATTAACAAACCCCAGTCAACCCATGCC
TTTGCAATGACCTGTATTTGGATTCATCTCAATAGAAAAGCTCAAAATGACAACTCCAAGCTACAGATTCCAATACCTCATTCCCTAAGA
CTTCACCATGAGTTCCTGCAGCAGAGTCTAAGAAATAAAAGTTTACAGATGAATGACTATAAGATTGCTCTATTGTGTAATGCATACTCT
ACAAATTCAGAATGTTTTACATTACCCATGGGAGCTCTGGTAGAAACTATTTATGGAAATGGAATTATGAGGATACCTCTCCCTGGAACA
AACTGTATGGCTTCAGGATCTATTACCCCCTTACCTATGAACCTCCTGGATTCACTGACAGTTCATGCCAAAATGAGCCTTATTCACAGC
ATTGCAACCAGGGTGATAAAACTTGCTCATGCAAAGTCCAGTGTGGCCTTGGCTCCAGCCCTAGTGGAAACTTACAGTCGTTTATTGGTC
TATATGGAAATAGAGTCTTTGGGCATCAAAGGATTTATCAGTCAGCTTTTGCCAACTGTTTTCAAATCACATGCATGGGGGATCTTACAC
ACACTCCTTGAGATGTTTAGCTACCGGATGCATCATATTCAGCCTCATTACAGAGTTCAGCTCCTGAGTCATCTTCATACTTTGGCTGCA
GTTGCACAAACAAACCAGAACCAGCTCCATCTTTGTGTCGAGAGCACTGCTCTCAGGCTTATAACAGCATTAGGTAGCTCAGAGGTACAA
CCGCAGTTTACACGCTTCCTTAGTGATCCCAAAACAGTGCTCTCAGCAGAATCTGAAGAACTGAACCGAGCCTTGATATTGACCTTGGCT
AGAGCAACTCATGTAACAGATTTTTTTACAGGCTCTGATTCAATTCAGGGAACTTGGTGTAAAGACATACTTCAGACCATCATGAGTTTC
ACTCCTCATAATTGGGCTTCACACACCCTGAGCTGTTTTCCAGGCCCACTACAGGCATTCTTCAAACAAAATAATGTGCCTCAGGAAAGC
CGTTTTAATCTGAAAAAAAATGTGGAGGAGGAGTATAGGAAGTGGAAGTCAATGAGCAACGAAAACGACATTATTACCCACTTCTCTATG
CAGGGCTCCCCTCCTCTCTTTCTTTGTCTTCTCTGGAAAATGCTCTTGGAAACAGATCATATTAATCAGATTGGCTATAGAGTATTAGAG
AGAATTGGAGCCAGGGCCTTGGTAGCCCATGTGAGGACATTTGCAGATTTCCTGGTATATGAGTTTTCTACATCAGCAGGGGGTCAGCAA
CTCAATAAATGCATTGAAATTCTTAATGACATGGTATGGAAGTATAACATTGTTACACTGGACAGATTAATTCTCTGCCTGGCCATGCGT
AGTCACGAAGGAAATGAAGCCCAGGTTTGTTATTTCATAATTCAGTTGCTGTTACTCAAACCAAACGATTTTAGAAATCGAGTAAGTGAC
TTTGTGAAGGAAAATTCCCCAGAGCACTGGTTACAGAATGACTGGCACACCAAGCACATGAATTATCACAAGAAATATCCAGAGAAGTTG
TATTTTGAGGGCCTCGCGGAACAGGTGGATCCTCCTGTACAGATCCAGTCTCCCTATCTGCCCATCTATTTTGGGAATGTGTGTCTTCGA
TTCCTTCCAGTATTTGATATAGTAATCCACAGATTTTTAGAGTTGCTTCCGGTATCCAAATCACTGGAGACTCTACTGGATCATCTAGGA
GGCTTATATAAATTTCATGATCGTCCAGTGACTTATCTGTATAACACTCTGCACTATTATGAAATGCACCTGAGAGACCGCGCATTTCTC
AAACGAAAACTCGTCCATGCGATCATTGGCTCTCTGAAGGATAATCGACCGCAGGGCTGGTGTCTAAGTGACACTTACCTGAAATGCGCT
ATGAATGCACGAGAGGAAAATCCTTGGGTTCCAGATGACACCTACTATTGCAGATTGATTGGCAGACTAGTCGATACGATGGCTGGCAAA
TCTCCTGGTCCCTTTCCAAACTGTGACTGGAGATTCAATGAGTTTCCCAACCCAGCTGCCCATGCTCTCCATGTTACTTGTGTGGAGCTC
ATGGCCTTGGCAGTTTCAGGCAAAGAAGTTGGGAATGCCCTTCTAAATGTTGTCCTAAAAAGTCAGCCTTTAGTGCCAAGAGAGAACATT
ACAGCATGGATGAATGCAATTGGTTTGATCATCACTGCCCTACCAGAGCCATATTGGATTGTTCTTCATGATCGAATTGTGAGTGTCATC
AGCAGCCCCAGCTTGACGTCTGAAACAGAGTGGGTTGGCTATCCATTCCGCCTCTTTGATTTCACTGCCTGTCATCAGTCCTACTCTGAG
ATGAGTTGTAGCTATACGTTAGCTCTTGCACATGCTGTGTGGCACCATTCTAGCATCGGACAACTTTCTCTCATTCCAAAGTTTCTTACT
GAAGTACTTCTTCCTATAGTGAAGACCGAATTCCAGTTGCTTTATGTATACCATCTTGTTGGACCATTTTTACAAAGATTTCAGCAAGAG
AGAACTCGTTGTATGATAGAGATTGGTGTGGCGTTTTATGACATGCTGCTGAATGTTGACCAGTGTAGCACCCATTTAAATTACATGGAT
CCCATCTGTGACTTCCTCTATCACATGAAGTATATGTTTACTGGTGACAGCGTGAAAGAGCAAGTAGAGAAGATTATCTGTAACTTAAAA
CCAGCTTTAAAACTTCGTCTTCGATTCATCACACACATTAGCAAGATGGAGCCAGCTGCAGTGCCTCCACAAGCCATGAACAGTGGGTCT
CCAGCACCTCAGTCTAATCAGGAACATTCCAGGCCTGAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAAGGAGAGCAACCAGTCTGCT
GTCCAGAAATTGGAAACAAACACGACGGAGTGTGGCGATGAGGATGATGAAGATAAACTGACCTGGAAGGATCGTTTCCCAGGTTACCTG
ATGAACTTTGCCTCCATCTTATTCATGATTGCCCTGACATTCTCAATCGTCTTTGGGGTGATAGTGTATCGAATAACAACTGCAGCCGCT
CTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGGGTGACAGTGACAGCAACAGCAGTCATCATCAACCTCGTGGTCATCCTCATCCTG
GACGAGATCTACGGCGCTGTGGCCAAGTGGCTCACCAAAATTGAGGTTCCGAAAACAGAACAGACTTTTGAAGAGCGCCTGATCCTCAAA
GCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCCATCTTCTATGTGGCCTTTTTCAAAGGGAGGTTTGTGGGCAGGCCTGGAAGCTAC
GTCTATGTATTCGATGGTTACCGCATGGAAGAGTGTGCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCAGCTCAGCATCATCATGTTG
GGGAAGCAGTTGATCCAGAACAACATCTTTGAGATTGGAGTCCCGAAGCTAAAGAAACTATTTCGAAAGCTGAAAGATGAGACCGAAGCT
GGAGAAACTGACTCTGCCCATTCGAAACATCCAGAGCAGTGGGACCTAGACTACAGCTTGGAACCATACACAGGACTGACTCCGGAGTAC
ATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTCTTCGTGGCCTCCTTTCCCCTGGCACCTGTGTTTGCCCTCCTCAACAACGTCATT
GAAGTGCGGCTCGATGCAAAGAAGTTTGTTACAGAGCTGAGACGGCCGGATGCTGTAAGAACCAAAGATATCGGAATCTGGTTTGACATT
CTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAACGCTTTTGTCATTGCGATCACCTCCGACTTTATCCCCCGCCTGGTGTACCAGTAC
TCCTACAGTCACAATGGGACTCTGCACGGCTTTGTCAACCACACCCTCTCCTTTTTCAACGTCAGCCAGCTGAAGGAGGGGACGCAGCCA
GAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGCAGGTTTAAGGATTACCGAGAGCCGCCATGGGCCCCGAACCCTTATGAGTTTTCG
AAACAGTACTGGTTTATTCTGTCCGCCCGTCTGGCTTTTGTCATAATCTTCCAGAACCTCGTGATGTTCCTGAGCGTCCTCGTGGACTGG
ATGATTCCAGACATCCCCACGGACATCAGCGACCAGATCAAGAAAGAGAAGAGCTTATTAGTGGATTTCTTCCTGAAAGAGGAGCATGAG
AAGCTCAAGCTGATGGATGAGCCGGCTCTGAGGAGCCCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGCCAGCTCAGCACCTTCAGGC
CAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCTCAGCACACCAATGTGTGAGCAGTTCAGCCTGCAGCAGAGGAGGGCACGGCAGCA
GAGACACGCACATGCACGTAAGCATGTTCCTACACCCACATGGCGTGCTGTCTGTCTGCAGGGGCCTGGCTTGATGGGGTCTTGAAGAGG
GGGCAGTGTGTAAAAAGAAAGAGCCTGACAGAATGAGTGTAGGAAGGAAGAGAAATGATGCTACATCTCAGAAACTTCAAGCTTAAGTTT
CTTTTAGGTCCCCTTTTAAGCTGCATCCTTTTGAGGGATTGGAACCCCACTGGGGTCTCTCCACCCCAGAGTCTCAGGCACCGCGAGCAT
TCCCATGTACCCTGGGGCACCCTCTTGTACTTCACCATCATTTCTGACTTTGACCAGCTGTAAGAGAAATGCAGTCAGGAGCACAGCATC
CCCTACTTACTATCACTACAAGAAAACTGAGTCACTTGCAGTGGGGCTGCCACAGTCTCAGCAGATGCAAATTAAGTTACAAGGCTGAAT
GGTGCAGCCGCTGGACCTGATAGTAAGGTGCAAAGGTCCAAACCTGGGCTTGTCTCCACTTCACGTCACAAAAACGTTTGGAGCTAAATG

>In-frame_ENST00000354577_ENST00000327087_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(amino acids)=1885AA_start in transcript=156_stop in transcript=5813
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALL
RYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVL
SLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQ
IPIPHSLRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVH
AKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLL
SHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKD
ILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHIN
QIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPN
DFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSL
ETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGR
LVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVL
HDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGP
FLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVP
PQAMNSGSPAPQSNQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIV
YRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGR
FVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEP
YTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDF
IPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVM

--------------------------------------------------------------
>In-frame_ENST00000354577_ENST00000546188_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(transcript)=6459nt_BP=4251nt
GAGGGAACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGAGGTCTCCGCCCCTCTGCCCCTATA
TTCCCAGAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAGATGGAGACGCAACTGCAGAGCATT
TTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCTGAAGATGAGAAAACAAAACTAATT
AGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATCCAGTGGATTGTTAAGTTTATTCAT
GGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGTCTCCTTCCACCCAGGCTGGTTTGT
GAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAACTGGTTCGGAAAATAATTGGGGGA
GTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAATACAGTGAGCTCTGCTGTTGTACAG
CAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCCTATTTTGCAGTCACTGAGATCAGG
AAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGATACCTTCAGGCCCACAGCAAGGATA
AACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCATGGAAACTGGATCCTGCTACTCTT
CGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGATCTGTTTGAACCACAGACTGCTTTGTTGAGATATGTATTGGAGCAGCCTTAT
TCCAGGGATATGGTCTGCAATATGCTAGGTTTAAATAAGCAGACCTTGAACATTGCTCAGCACAAGCAGCGCTGCCCTGTGCTGGAGGAC
CAGTTGGTGGATCTGGTTGTTTATGCCATGGAGCGATCTGAGACCGAGGAGAAGTTTGACGATGGGGGAACAAGCCAACTCCTGTGGCAG
CATCTCTCAAGTCAGCTCATTTTCTTTGTGCTTTTCCAGTTTGCAAGTTTTCCACATATGGTGCTTTCTCTTCATCAGAAGTTAGCAGGG
CGAGGACTGATTAAAGGCAGAGATCATCTTATGTGGGTTCTCCTGCAATTCATTTCTGGAAGTATTCAGAAAAATGCACTAGCTGATTTT
CTCCCTGTGATGAAGCTCTTCGACTTGCTATACCCAGAAAAAGAATATATCCCAGTTCCTGATATTAACAAACCCCAGTCAACCCATGCC
TTTGCAATGACCTGTATTTGGATTCATCTCAATAGAAAAGCTCAAAATGACAACTCCAAGCTACAGATTCCAATACCTCATTCCCTAAGA
CTTCACCATGAGTTCCTGCAGCAGAGTCTAAGAAATAAAAGTTTACAGATGAATGACTATAAGATTGCTCTATTGTGTAATGCATACTCT
ACAAATTCAGAATGTTTTACATTACCCATGGGAGCTCTGGTAGAAACTATTTATGGAAATGGAATTATGAGGATACCTCTCCCTGGAACA
AACTGTATGGCTTCAGGATCTATTACCCCCTTACCTATGAACCTCCTGGATTCACTGACAGTTCATGCCAAAATGAGCCTTATTCACAGC
ATTGCAACCAGGGTGATAAAACTTGCTCATGCAAAGTCCAGTGTGGCCTTGGCTCCAGCCCTAGTGGAAACTTACAGTCGTTTATTGGTC
TATATGGAAATAGAGTCTTTGGGCATCAAAGGATTTATCAGTCAGCTTTTGCCAACTGTTTTCAAATCACATGCATGGGGGATCTTACAC
ACACTCCTTGAGATGTTTAGCTACCGGATGCATCATATTCAGCCTCATTACAGAGTTCAGCTCCTGAGTCATCTTCATACTTTGGCTGCA
GTTGCACAAACAAACCAGAACCAGCTCCATCTTTGTGTCGAGAGCACTGCTCTCAGGCTTATAACAGCATTAGGTAGCTCAGAGGTACAA
CCGCAGTTTACACGCTTCCTTAGTGATCCCAAAACAGTGCTCTCAGCAGAATCTGAAGAACTGAACCGAGCCTTGATATTGACCTTGGCT
AGAGCAACTCATGTAACAGATTTTTTTACAGGCTCTGATTCAATTCAGGGAACTTGGTGTAAAGACATACTTCAGACCATCATGAGTTTC
ACTCCTCATAATTGGGCTTCACACACCCTGAGCTGTTTTCCAGGCCCACTACAGGCATTCTTCAAACAAAATAATGTGCCTCAGGAAAGC
CGTTTTAATCTGAAAAAAAATGTGGAGGAGGAGTATAGGAAGTGGAAGTCAATGAGCAACGAAAACGACATTATTACCCACTTCTCTATG
CAGGGCTCCCCTCCTCTCTTTCTTTGTCTTCTCTGGAAAATGCTCTTGGAAACAGATCATATTAATCAGATTGGCTATAGAGTATTAGAG
AGAATTGGAGCCAGGGCCTTGGTAGCCCATGTGAGGACATTTGCAGATTTCCTGGTATATGAGTTTTCTACATCAGCAGGGGGTCAGCAA
CTCAATAAATGCATTGAAATTCTTAATGACATGGTATGGAAGTATAACATTGTTACACTGGACAGATTAATTCTCTGCCTGGCCATGCGT
AGTCACGAAGGAAATGAAGCCCAGGTTTGTTATTTCATAATTCAGTTGCTGTTACTCAAACCAAACGATTTTAGAAATCGAGTAAGTGAC
TTTGTGAAGGAAAATTCCCCAGAGCACTGGTTACAGAATGACTGGCACACCAAGCACATGAATTATCACAAGAAATATCCAGAGAAGTTG
TATTTTGAGGGCCTCGCGGAACAGGTGGATCCTCCTGTACAGATCCAGTCTCCCTATCTGCCCATCTATTTTGGGAATGTGTGTCTTCGA
TTCCTTCCAGTATTTGATATAGTAATCCACAGATTTTTAGAGTTGCTTCCGGTATCCAAATCACTGGAGACTCTACTGGATCATCTAGGA
GGCTTATATAAATTTCATGATCGTCCAGTGACTTATCTGTATAACACTCTGCACTATTATGAAATGCACCTGAGAGACCGCGCATTTCTC
AAACGAAAACTCGTCCATGCGATCATTGGCTCTCTGAAGGATAATCGACCGCAGGGCTGGTGTCTAAGTGACACTTACCTGAAATGCGCT
ATGAATGCACGAGAGGAAAATCCTTGGGTTCCAGATGACACCTACTATTGCAGATTGATTGGCAGACTAGTCGATACGATGGCTGGCAAA
TCTCCTGGTCCCTTTCCAAACTGTGACTGGAGATTCAATGAGTTTCCCAACCCAGCTGCCCATGCTCTCCATGTTACTTGTGTGGAGCTC
ATGGCCTTGGCAGTTTCAGGCAAAGAAGTTGGGAATGCCCTTCTAAATGTTGTCCTAAAAAGTCAGCCTTTAGTGCCAAGAGAGAACATT
ACAGCATGGATGAATGCAATTGGTTTGATCATCACTGCCCTACCAGAGCCATATTGGATTGTTCTTCATGATCGAATTGTGAGTGTCATC
AGCAGCCCCAGCTTGACGTCTGAAACAGAGTGGGTTGGCTATCCATTCCGCCTCTTTGATTTCACTGCCTGTCATCAGTCCTACTCTGAG
ATGAGTTGTAGCTATACGTTAGCTCTTGCACATGCTGTGTGGCACCATTCTAGCATCGGACAACTTTCTCTCATTCCAAAGTTTCTTACT
GAAGTACTTCTTCCTATAGTGAAGACCGAATTCCAGTTGCTTTATGTATACCATCTTGTTGGACCATTTTTACAAAGATTTCAGCAAGAG
AGAACTCGTTGTATGATAGAGATTGGTGTGGCGTTTTATGACATGCTGCTGAATGTTGACCAGTGTAGCACCCATTTAAATTACATGGAT
CCCATCTGTGACTTCCTCTATCACATGAAGTATATGTTTACTGGTGACAGCGTGAAAGAGCAAGTAGAGAAGATTATCTGTAACTTAAAA
CCAGCTTTAAAACTTCGTCTTCGATTCATCACACACATTAGCAAGATGGAGCCAGCTGCAGTGCCTCCACAAGCCATGAACAGTGGGTCT
CCAGCACCTCAGTCTAATCAGGAACATTCCAGGCCTGAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAAGGAGAGCAACCAGTCTGCT
GTCCAGAAATTGGAAACAAACACGACGGAGTGTGGCGATGAGGATGATGAAGATAAACTGACCTGGAAGGATCGTTTCCCAGGTTACCTG
ATGAACTTTGCCTCCATCTTATTCATGATTGCCCTGACATTCTCAATCGTCTTTGGGGTGATAGTGTATCGAATAACAACTGCAGCCGCT
CTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGGGTGACAGTGACAGCAACAGCAGTCATCATCAACCTCGTGGTCATCCTCATCCTG
GACGAGATCTACGGCGCTGTGGCCAAGTGGCTCACCAAAATTGAGGTTCCGAAAACAGAACAGACTTTTGAAGAGCGCCTGATCCTCAAA
GCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCCATCTTCTATGTGGCCTTTTTCAAAGGGAGGTTTGTGGGCAGGCCTGGAAGCTAC
GTCTATGTATTCGATGGTTACCGCATGGAAGAGTGTGCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCAGCTCAGCATCATCATGTTG
GGGAAGCAGTTGATCCAGAACAACATCTTTGAGATTGGAGTCCCGAAGCTAAAGAAACTATTTCGAAAGCTGAAAGATGAGACCGAAGCT
GGAGAAACTGACTCTGCCCATTCGAAACATCCAGAGCAGTGGGACCTAGACTACAGCTTGGAACCATACACAGGACTGACTCCGGAGTAC
ATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTCTTCGTGGCCTCCTTTCCCCTGGCACCTGTGTTTGCCCTCCTCAACAACGTCATT
GAAGTGCGGCTCGATGCAAAGAAGTTTGTTACAGAGCTGAGACGGCCGGATGCTGTAAGAACCAAAGATATCGGAATCTGGTTTGACATT
CTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAACGCTTTTGTCATTGCGATCACCTCCGACTTTATCCCCCGCCTGGTGTACCAGTAC
TCCTACAGTCACAATGGGACTCTGCACGGCTTTGTCAACCACACCCTCTCCTTTTTCAACGTCAGCCAGCTGAAGGAGGGGACGCAGCCA
GAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGCAGGTTTAAGGATTACCGAGAGCCGCCATGGGCCCCGAACCCTTATGAGTTTTCG
AAACAGTACTGGTTTATTCTGTCCGCCCGTCTGGCTTTTGTCATAATCTTCCAGAACCTCGTGATGTTCCTGAGCGTCCTCGTGGACTGG
ATGATTCCAGACATCCCCACGGACATCAGCGACCAGATCAAGAAAGAGAAGAGCTTATTAGTGGATTTCTTCCTGAAAGAGGAGCATGAG
AAGCTCAAGCTGATGGATGAGCCGGCTCTGAGGAGCCCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGCCAGCTCAGCACCTTCAGGC
CAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCTCAGCACACCAATGTGTGAGCAGTTCAGCCTGCAGCAGAGGAGGGCACGGCAGCA
GAGACACGCACATGCACGTAAGCATGTTCCTACACCCACATGGCGTGCTGTCTGTCTGCAGGGGCCTGGCTTGATGGGGTCTTGAAGAGG
GGGCAGTGTGTAAAAAGAAAGAGCCTGACAGAATGAGTGTAGGAAGGAAGAGAAATGATGCTACATCTCAGAAACTTCAAGCTTAAGTTT
CTTTTAGGTCCCCTTTTAAGCTGCATCCTTTTGAGGGATTGGAACCCCACTGGGGTCTCTCCACCCCAGAGTCTCAGGCACCGCGAGCAT
TCCCATGTACCCTGGGGCACCCTCTTGTACTTCACCATCATTTCTGACTTTGACCAGCTGTAAGAGAAATGCAGTCAGGAGCACAGCATC
CCCTACTTACTATCACTACAAGAAAACTGAGTCACTTGCAGTGGGGCTGCCACAGTCTCAGCAGATGCAAATTAAGTTACAAGGCTGAAT
GGTGCAGCCGCTGGACCTGATAGTAAGGTGCAAAGGTCCAAACCTGGGCTTGTCTCCACTTCACGTCACAAAAACGTTTGGAGCTAAATG

>In-frame_ENST00000354577_ENST00000546188_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(amino acids)=1885AA_start in transcript=156_stop in transcript=5813
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALL
RYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVL
SLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQ
IPIPHSLRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVH
AKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLL
SHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKD
ILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHIN
QIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPN
DFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSL
ETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGR
LVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVL
HDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGP
FLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVP
PQAMNSGSPAPQSNQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIV
YRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGR
FVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEP
YTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDF
IPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVM

--------------------------------------------------------------
>In-frame_ENST00000354577_ENST00000356134_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(transcript)=6459nt_BP=4251nt
GAGGGAACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGAGGTCTCCGCCCCTCTGCCCCTATA
TTCCCAGAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAGATGGAGACGCAACTGCAGAGCATT
TTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCTGAAGATGAGAAAACAAAACTAATT
AGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATCCAGTGGATTGTTAAGTTTATTCAT
GGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGTCTCCTTCCACCCAGGCTGGTTTGT
GAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAACTGGTTCGGAAAATAATTGGGGGA
GTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAATACAGTGAGCTCTGCTGTTGTACAG
CAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCCTATTTTGCAGTCACTGAGATCAGG
AAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGATACCTTCAGGCCCACAGCAAGGATA
AACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCATGGAAACTGGATCCTGCTACTCTT
CGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGATCTGTTTGAACCACAGACTGCTTTGTTGAGATATGTATTGGAGCAGCCTTAT
TCCAGGGATATGGTCTGCAATATGCTAGGTTTAAATAAGCAGACCTTGAACATTGCTCAGCACAAGCAGCGCTGCCCTGTGCTGGAGGAC
CAGTTGGTGGATCTGGTTGTTTATGCCATGGAGCGATCTGAGACCGAGGAGAAGTTTGACGATGGGGGAACAAGCCAACTCCTGTGGCAG
CATCTCTCAAGTCAGCTCATTTTCTTTGTGCTTTTCCAGTTTGCAAGTTTTCCACATATGGTGCTTTCTCTTCATCAGAAGTTAGCAGGG
CGAGGACTGATTAAAGGCAGAGATCATCTTATGTGGGTTCTCCTGCAATTCATTTCTGGAAGTATTCAGAAAAATGCACTAGCTGATTTT
CTCCCTGTGATGAAGCTCTTCGACTTGCTATACCCAGAAAAAGAATATATCCCAGTTCCTGATATTAACAAACCCCAGTCAACCCATGCC
TTTGCAATGACCTGTATTTGGATTCATCTCAATAGAAAAGCTCAAAATGACAACTCCAAGCTACAGATTCCAATACCTCATTCCCTAAGA
CTTCACCATGAGTTCCTGCAGCAGAGTCTAAGAAATAAAAGTTTACAGATGAATGACTATAAGATTGCTCTATTGTGTAATGCATACTCT
ACAAATTCAGAATGTTTTACATTACCCATGGGAGCTCTGGTAGAAACTATTTATGGAAATGGAATTATGAGGATACCTCTCCCTGGAACA
AACTGTATGGCTTCAGGATCTATTACCCCCTTACCTATGAACCTCCTGGATTCACTGACAGTTCATGCCAAAATGAGCCTTATTCACAGC
ATTGCAACCAGGGTGATAAAACTTGCTCATGCAAAGTCCAGTGTGGCCTTGGCTCCAGCCCTAGTGGAAACTTACAGTCGTTTATTGGTC
TATATGGAAATAGAGTCTTTGGGCATCAAAGGATTTATCAGTCAGCTTTTGCCAACTGTTTTCAAATCACATGCATGGGGGATCTTACAC
ACACTCCTTGAGATGTTTAGCTACCGGATGCATCATATTCAGCCTCATTACAGAGTTCAGCTCCTGAGTCATCTTCATACTTTGGCTGCA
GTTGCACAAACAAACCAGAACCAGCTCCATCTTTGTGTCGAGAGCACTGCTCTCAGGCTTATAACAGCATTAGGTAGCTCAGAGGTACAA
CCGCAGTTTACACGCTTCCTTAGTGATCCCAAAACAGTGCTCTCAGCAGAATCTGAAGAACTGAACCGAGCCTTGATATTGACCTTGGCT
AGAGCAACTCATGTAACAGATTTTTTTACAGGCTCTGATTCAATTCAGGGAACTTGGTGTAAAGACATACTTCAGACCATCATGAGTTTC
ACTCCTCATAATTGGGCTTCACACACCCTGAGCTGTTTTCCAGGCCCACTACAGGCATTCTTCAAACAAAATAATGTGCCTCAGGAAAGC
CGTTTTAATCTGAAAAAAAATGTGGAGGAGGAGTATAGGAAGTGGAAGTCAATGAGCAACGAAAACGACATTATTACCCACTTCTCTATG
CAGGGCTCCCCTCCTCTCTTTCTTTGTCTTCTCTGGAAAATGCTCTTGGAAACAGATCATATTAATCAGATTGGCTATAGAGTATTAGAG
AGAATTGGAGCCAGGGCCTTGGTAGCCCATGTGAGGACATTTGCAGATTTCCTGGTATATGAGTTTTCTACATCAGCAGGGGGTCAGCAA
CTCAATAAATGCATTGAAATTCTTAATGACATGGTATGGAAGTATAACATTGTTACACTGGACAGATTAATTCTCTGCCTGGCCATGCGT
AGTCACGAAGGAAATGAAGCCCAGGTTTGTTATTTCATAATTCAGTTGCTGTTACTCAAACCAAACGATTTTAGAAATCGAGTAAGTGAC
TTTGTGAAGGAAAATTCCCCAGAGCACTGGTTACAGAATGACTGGCACACCAAGCACATGAATTATCACAAGAAATATCCAGAGAAGTTG
TATTTTGAGGGCCTCGCGGAACAGGTGGATCCTCCTGTACAGATCCAGTCTCCCTATCTGCCCATCTATTTTGGGAATGTGTGTCTTCGA
TTCCTTCCAGTATTTGATATAGTAATCCACAGATTTTTAGAGTTGCTTCCGGTATCCAAATCACTGGAGACTCTACTGGATCATCTAGGA
GGCTTATATAAATTTCATGATCGTCCAGTGACTTATCTGTATAACACTCTGCACTATTATGAAATGCACCTGAGAGACCGCGCATTTCTC
AAACGAAAACTCGTCCATGCGATCATTGGCTCTCTGAAGGATAATCGACCGCAGGGCTGGTGTCTAAGTGACACTTACCTGAAATGCGCT
ATGAATGCACGAGAGGAAAATCCTTGGGTTCCAGATGACACCTACTATTGCAGATTGATTGGCAGACTAGTCGATACGATGGCTGGCAAA
TCTCCTGGTCCCTTTCCAAACTGTGACTGGAGATTCAATGAGTTTCCCAACCCAGCTGCCCATGCTCTCCATGTTACTTGTGTGGAGCTC
ATGGCCTTGGCAGTTTCAGGCAAAGAAGTTGGGAATGCCCTTCTAAATGTTGTCCTAAAAAGTCAGCCTTTAGTGCCAAGAGAGAACATT
ACAGCATGGATGAATGCAATTGGTTTGATCATCACTGCCCTACCAGAGCCATATTGGATTGTTCTTCATGATCGAATTGTGAGTGTCATC
AGCAGCCCCAGCTTGACGTCTGAAACAGAGTGGGTTGGCTATCCATTCCGCCTCTTTGATTTCACTGCCTGTCATCAGTCCTACTCTGAG
ATGAGTTGTAGCTATACGTTAGCTCTTGCACATGCTGTGTGGCACCATTCTAGCATCGGACAACTTTCTCTCATTCCAAAGTTTCTTACT
GAAGTACTTCTTCCTATAGTGAAGACCGAATTCCAGTTGCTTTATGTATACCATCTTGTTGGACCATTTTTACAAAGATTTCAGCAAGAG
AGAACTCGTTGTATGATAGAGATTGGTGTGGCGTTTTATGACATGCTGCTGAATGTTGACCAGTGTAGCACCCATTTAAATTACATGGAT
CCCATCTGTGACTTCCTCTATCACATGAAGTATATGTTTACTGGTGACAGCGTGAAAGAGCAAGTAGAGAAGATTATCTGTAACTTAAAA
CCAGCTTTAAAACTTCGTCTTCGATTCATCACACACATTAGCAAGATGGAGCCAGCTGCAGTGCCTCCACAAGCCATGAACAGTGGGTCT
CCAGCACCTCAGTCTAATCAGGAACATTCCAGGCCTGAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAAGGAGAGCAACCAGTCTGCT
GTCCAGAAATTGGAAACAAACACGACGGAGTGTGGCGATGAGGATGATGAAGATAAACTGACCTGGAAGGATCGTTTCCCAGGTTACCTG
ATGAACTTTGCCTCCATCTTATTCATGATTGCCCTGACATTCTCAATCGTCTTTGGGGTGATAGTGTATCGAATAACAACTGCAGCCGCT
CTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGGGTGACAGTGACAGCAACAGCAGTCATCATCAACCTCGTGGTCATCCTCATCCTG
GACGAGATCTACGGCGCTGTGGCCAAGTGGCTCACCAAAATTGAGGTTCCGAAAACAGAACAGACTTTTGAAGAGCGCCTGATCCTCAAA
GCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCCATCTTCTATGTGGCCTTTTTCAAAGGGAGGTTTGTGGGCAGGCCTGGAAGCTAC
GTCTATGTATTCGATGGTTACCGCATGGAAGAGTGTGCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCAGCTCAGCATCATCATGTTG
GGGAAGCAGTTGATCCAGAACAACATCTTTGAGATTGGAGTCCCGAAGCTAAAGAAACTATTTCGAAAGCTGAAAGATGAGACCGAAGCT
GGAGAAACTGACTCTGCCCATTCGAAACATCCAGAGCAGTGGGACCTAGACTACAGCTTGGAACCATACACAGGACTGACTCCGGAGTAC
ATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTCTTCGTGGCCTCCTTTCCCCTGGCACCTGTGTTTGCCCTCCTCAACAACGTCATT
GAAGTGCGGCTCGATGCAAAGAAGTTTGTTACAGAGCTGAGACGGCCGGATGCTGTAAGAACCAAAGATATCGGAATCTGGTTTGACATT
CTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAACGCTTTTGTCATTGCGATCACCTCCGACTTTATCCCCCGCCTGGTGTACCAGTAC
TCCTACAGTCACAATGGGACTCTGCACGGCTTTGTCAACCACACCCTCTCCTTTTTCAACGTCAGCCAGCTGAAGGAGGGGACGCAGCCA
GAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGCAGGTTTAAGGATTACCGAGAGCCGCCATGGGCCCCGAACCCTTATGAGTTTTCG
AAACAGTACTGGTTTATTCTGTCCGCCCGTCTGGCTTTTGTCATAATCTTCCAGAACCTCGTGATGTTCCTGAGCGTCCTCGTGGACTGG
ATGATTCCAGACATCCCCACGGACATCAGCGACCAGATCAAGAAAGAGAAGAGCTTATTAGTGGATTTCTTCCTGAAAGAGGAGCATGAG
AAGCTCAAGCTGATGGATGAGCCGGCTCTGAGGAGCCCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGCCAGCTCAGCACCTTCAGGC
CAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCTCAGCACACCAATGTGTGAGCAGTTCAGCCTGCAGCAGAGGAGGGCACGGCAGCA
GAGACACGCACATGCACGTAAGCATGTTCCTACACCCACATGGCGTGCTGTCTGTCTGCAGGGGCCTGGCTTGATGGGGTCTTGAAGAGG
GGGCAGTGTGTAAAAAGAAAGAGCCTGACAGAATGAGTGTAGGAAGGAAGAGAAATGATGCTACATCTCAGAAACTTCAAGCTTAAGTTT
CTTTTAGGTCCCCTTTTAAGCTGCATCCTTTTGAGGGATTGGAACCCCACTGGGGTCTCTCCACCCCAGAGTCTCAGGCACCGCGAGCAT
TCCCATGTACCCTGGGGCACCCTCTTGTACTTCACCATCATTTCTGACTTTGACCAGCTGTAAGAGAAATGCAGTCAGGAGCACAGCATC
CCCTACTTACTATCACTACAAGAAAACTGAGTCACTTGCAGTGGGGCTGCCACAGTCTCAGCAGATGCAAATTAAGTTACAAGGCTGAAT
GGTGCAGCCGCTGGACCTGATAGTAAGGTGCAAAGGTCCAAACCTGGGCTTGTCTCCACTTCACGTCACAAAAACGTTTGGAGCTAAATG

>In-frame_ENST00000354577_ENST00000356134_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(amino acids)=1885AA_start in transcript=156_stop in transcript=5813
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALL
RYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVL
SLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQ
IPIPHSLRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVH
AKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLL
SHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKD
ILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHIN
QIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPN
DFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSL
ETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGR
LVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVL
HDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGP
FLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVP
PQAMNSGSPAPQSNQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIV
YRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGR
FVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEP
YTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDF
IPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVM

--------------------------------------------------------------
>In-frame_ENST00000368060_ENST00000327087_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(transcript)=6468nt_BP=4257nt
GTTCCTGCTGTTGGCTGGGCTCGGGAGGGAACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGA
GGTCTCCGCCCCTCTGCCCCTATATTCCCAGAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAG
ATGGAGACGCAACTGCAGAGCATTTTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCT
GAAGATGAGAAAACAAAACTAATTAGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATC
CAGTGGATTGTTAAGTTTATTCATGGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGT
CTCCTTCCACCCAGGCTGGTTTGTGAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAA
CTGGTTCGGAAAATAATTGGGGGAGTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAAT
ACAGTGAGCTCTGCTGTTGTACAGCAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCC
TATTTTGCAGTCACTGAGATCAGGAAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGAT
ACCTTCAGGCCCACAGCAAGGATAAACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCA
TGGAAACTGGATCCTGCTACTCTTCGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGATCTGTTTGAACCACAGACTGCTTTGTTG
AGATATGTATTGGAGCAGCCTTATTCCAGGGATATGGTCTGCAATATGCTAGGTTTAAATAAGCAGCACAAGCAGCGCTGCCCTGTGCTG
GAGGACCAGTTGGTGGATCTGGTTGTTTATGCCATGGAGCGATCTGAGACCGAGGAGAAGTTTGACGATGGGGGAACAAGCCAACTCCTG
TGGCAGCATCTCTCAAGTCAGCTCATTTTCTTTGTGCTTTTCCAGTTTGCAAGTTTTCCACATATGGTGCTTTCTCTTCATCAGAAGTTA
GCAGGGCGAGGACTGATTAAAGGCAGAGATCATCTTATGTGGGTTCTCCTGCAATTCATTTCTGGAAGTATTCAGAAAAATGCACTAGCT
GATTTTCTCCCTGTGATGAAGCTCTTCGACTTGCTATACCCAGAAAAAGAATATATCCCAGTTCCTGATATTAACAAACCCCAGTCAACC
CATGCCTTTGCAATGACCTGTATTTGGATTCATCTCAATAGAAAAGCTCAAAATGACAACTCCAAGCTACAGATTCCAATACCTCATTCC
CTAAGACTTCACCATGAGTTCCTGCAGCAGAGTCTAAGAAATAAAAGTTTACAGATGAATGACTATAAGATTGCTCTATTGTGTAATGCA
TACTCTACAAATTCAGAATGTTTTACATTACCCATGGGAGCTCTGGTAGAAACTATTTATGGAAATGGAATTATGAGGATACCTCTCCCT
GGAACAAACTGTATGGCTTCAGGATCTATTACCCCCTTACCTATGAACCTCCTGGATTCACTGACAGTTCATGCCAAAATGAGCCTTATT
CACAGCATTGCAACCAGGGTGATAAAACTTGCTCATGCAAAGTCCAGTGTGGCCTTGGCTCCAGCCCTAGTGGAAACTTACAGTCGTTTA
TTGGTCTATATGGAAATAGAGTCTTTGGGCATCAAAGGATTTATCAGTCAGCTTTTGCCAACTGTTTTCAAATCACATGCATGGGGGATC
TTACACACACTCCTTGAGATGTTTAGCTACCGGATGCATCATATTCAGCCTCATTACAGAGTTCAGCTCCTGAGTCATCTTCATACTTTG
GCTGCAGTTGCACAAACAAACCAGAACCAGCTCCATCTTTGTGTCGAGAGCACTGCTCTCAGGCTTATAACAGCATTAGGTAGCTCAGAG
GTACAACCGCAGTTTACACGCTTCCTTAGTGATCCCAAAACAGTGCTCTCAGCAGAATCTGAAGAACTGAACCGAGCCTTGATATTGACC
TTGGCTAGAGCAACTCATGTAACAGATTTTTTTACAGGCTCTGATTCAATTCAGGGAACTTGGTGTAAAGACATACTTCAGACCATCATG
AGTTTCACTCCTCATAATTGGGCTTCACACACCCTGAGCTGTTTTCCAGGCCCACTACAGGCATTCTTCAAACAAAATAATGTGCCTCAG
GAAAGCCGTTTTAATCTGAAAAAAAATGTGGAGGAGGAGTATAGGAAGTGGAAGTCAATGAGCAACGAAAACGACATTATTACCCACTTC
TCTATGCAGGGCTCCCCTCCTCTCTTTCTTTGTCTTCTCTGGAAAATGCTCTTGGAAACAGATCATATTAATCAGATTGGCTATAGAGTA
TTAGAGAGAATTGGAGCCAGGGCCTTGGTAGCCCATGTGAGGACATTTGCAGATTTCCTGGTATATGAGTTTTCTACATCAGCAGGGGGT
CAGCAACTCAATAAATGCATTGAAATTCTTAATGACATGGTATGGAAGTATAACATTGTTACACTGGACAGATTAATTCTCTGCCTGGCC
ATGCGTAGTCACGAAGGAAATGAAGCCCAGGTTTGTTATTTCATAATTCAGTTGCTGTTACTCAAACCAAACGATTTTAGAAATCGAGTA
AGTGACTTTGTGAAGGAAAATTCCCCAGAGCACTGGTTACAGAATGACTGGCACACCAAGCACATGAATTATCACAAGAAATATCCAGAG
AAGTTGTATTTTGAGGGCCTCGCGGAACAGGTGGATCCTCCTGTACAGATCCAGTCTCCCTATCTGCCCATCTATTTTGGGAATGTGTGT
CTTCGATTCCTTCCAGTATTTGATATAGTAATCCACAGATTTTTAGAGTTGCTTCCGGTATCCAAATCACTGGAGACTCTACTGGATCAT
CTAGGAGGCTTATATAAATTTCATGATCGTCCAGTGACTTATCTGTATAACACTCTGCACTATTATGAAATGCACCTGAGAGACCGCGCA
TTTCTCAAACGAAAACTCGTCCATGCGATCATTGGCTCTCTGAAGGATAATCGACCGCAGGGCTGGTGTCTAAGTGACACTTACCTGAAA
TGCGCTATGAATGCACGAGAGGAAAATCCTTGGGTTCCAGATGACACCTACTATTGCAGATTGATTGGCAGACTAGTCGATACGATGGCT
GGCAAATCTCCTGGTCCCTTTCCAAACTGTGACTGGAGATTCAATGAGTTTCCCAACCCAGCTGCCCATGCTCTCCATGTTACTTGTGTG
GAGCTCATGGCCTTGGCAGTTTCAGGCAAAGAAGTTGGGAATGCCCTTCTAAATGTTGTCCTAAAAAGTCAGCCTTTAGTGCCAAGAGAG
AACATTACAGCATGGATGAATGCAATTGGTTTGATCATCACTGCCCTACCAGAGCCATATTGGATTGTTCTTCATGATCGAATTGTGAGT
GTCATCAGCAGCCCCAGCTTGACGTCTGAAACAGAGTGGGTTGGCTATCCATTCCGCCTCTTTGATTTCACTGCCTGTCATCAGTCCTAC
TCTGAGATGAGTTGTAGCTATACGTTAGCTCTTGCACATGCTGTGTGGCACCATTCTAGCATCGGACAACTTTCTCTCATTCCAAAGTTT
CTTACTGAAGTACTTCTTCCTATAGTGAAGACCGAATTCCAGTTGCTTTATGTATACCATCTTGTTGGACCATTTTTACAAAGATTTCAG
CAAGAGAGAACTCGTTGTATGATAGAGATTGGTGTGGCGTTTTATGACATGCTGCTGAATGTTGACCAGTGTAGCACCCATTTAAATTAC
ATGGATCCCATCTGTGACTTCCTCTATCACATGAAGTATATGTTTACTGGTGACAGCGTGAAAGAGCAAGTAGAGAAGATTATCTGTAAC
TTAAAACCAGCTTTAAAACTTCGTCTTCGATTCATCACACACATTAGCAAGATGGAGCCAGCTGCAGTGCCTCCACAAGCCATGAACAGT
GGGTCTCCAGCACCTCAGTCTAATCAGGAACATTCCAGGCCTGAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAAGGAGAGCAACCAG
TCTGCTGTCCAGAAATTGGAAACAAACACGACGGAGTGTGGCGATGAGGATGATGAAGATAAACTGACCTGGAAGGATCGTTTCCCAGGT
TACCTGATGAACTTTGCCTCCATCTTATTCATGATTGCCCTGACATTCTCAATCGTCTTTGGGGTGATAGTGTATCGAATAACAACTGCA
GCCGCTCTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGGGTGACAGTGACAGCAACAGCAGTCATCATCAACCTCGTGGTCATCCTC
ATCCTGGACGAGATCTACGGCGCTGTGGCCAAGTGGCTCACCAAAATTGAGGTTCCGAAAACAGAACAGACTTTTGAAGAGCGCCTGATC
CTCAAAGCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCCATCTTCTATGTGGCCTTTTTCAAAGGGAGGTTTGTGGGCAGGCCTGGA
AGCTACGTCTATGTATTCGATGGTTACCGCATGGAAGAGTGTGCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCAGCTCAGCATCATC
ATGTTGGGGAAGCAGTTGATCCAGAACAACATCTTTGAGATTGGAGTCCCGAAGCTAAAGAAACTATTTCGAAAGCTGAAAGATGAGACC
GAAGCTGGAGAAACTGACTCTGCCCATTCGAAACATCCAGAGCAGTGGGACCTAGACTACAGCTTGGAACCATACACAGGACTGACTCCG
GAGTACATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTCTTCGTGGCCTCCTTTCCCCTGGCACCTGTGTTTGCCCTCCTCAACAAC
GTCATTGAAGTGCGGCTCGATGCAAAGAAGTTTGTTACAGAGCTGAGACGGCCGGATGCTGTAAGAACCAAAGATATCGGAATCTGGTTT
GACATTCTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAACGCTTTTGTCATTGCGATCACCTCCGACTTTATCCCCCGCCTGGTGTAC
CAGTACTCCTACAGTCACAATGGGACTCTGCACGGCTTTGTCAACCACACCCTCTCCTTTTTCAACGTCAGCCAGCTGAAGGAGGGGACG
CAGCCAGAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGCAGGTTTAAGGATTACCGAGAGCCGCCATGGGCCCCGAACCCTTATGAG
TTTTCGAAACAGTACTGGTTTATTCTGTCCGCCCGTCTGGCTTTTGTCATAATCTTCCAGAACCTCGTGATGTTCCTGAGCGTCCTCGTG
GACTGGATGATTCCAGACATCCCCACGGACATCAGCGACCAGATCAAGAAAGAGAAGAGCTTATTAGTGGATTTCTTCCTGAAAGAGGAG
CATGAGAAGCTCAAGCTGATGGATGAGCCGGCTCTGAGGAGCCCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGCCAGCTCAGCACCT
TCAGGCCAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCTCAGCACACCAATGTGTGAGCAGTTCAGCCTGCAGCAGAGGAGGGCACG
GCAGCAGAGACACGCACATGCACGTAAGCATGTTCCTACACCCACATGGCGTGCTGTCTGTCTGCAGGGGCCTGGCTTGATGGGGTCTTG
AAGAGGGGGCAGTGTGTAAAAAGAAAGAGCCTGACAGAATGAGTGTAGGAAGGAAGAGAAATGATGCTACATCTCAGAAACTTCAAGCTT
AAGTTTCTTTTAGGTCCCCTTTTAAGCTGCATCCTTTTGAGGGATTGGAACCCCACTGGGGTCTCTCCACCCCAGAGTCTCAGGCACCGC
GAGCATTCCCATGTACCCTGGGGCACCCTCTTGTACTTCACCATCATTTCTGACTTTGACCAGCTGTAAGAGAAATGCAGTCAGGAGCAC
AGCATCCCCTACTTACTATCACTACAAGAAAACTGAGTCACTTGCAGTGGGGCTGCCACAGTCTCAGCAGATGCAAATTAAGTTACAAGG
CTGAATGGTGCAGCCGCTGGACCTGATAGTAAGGTGCAAAGGTCCAAACCTGGGCTTGTCTCCACTTCACGTCACAAAAACGTTTGGAGC

>In-frame_ENST00000368060_ENST00000327087_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(amino acids)=1879AA_start in transcript=180_stop in transcript=5819
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALL
RYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKL
AGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHS
LRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLI
HSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTL
AAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIM
SFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRV
LERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRV
SDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDH
LGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMA
GKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVS
VISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQ
QERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMNS
GSPAPQSNQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTA
AALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPG
SYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTGLTP
EYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVY
QYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLV

--------------------------------------------------------------
>In-frame_ENST00000368060_ENST00000546188_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(transcript)=6465nt_BP=4257nt
GTTCCTGCTGTTGGCTGGGCTCGGGAGGGAACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGA
GGTCTCCGCCCCTCTGCCCCTATATTCCCAGAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAG
ATGGAGACGCAACTGCAGAGCATTTTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCT
GAAGATGAGAAAACAAAACTAATTAGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATC
CAGTGGATTGTTAAGTTTATTCATGGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGT
CTCCTTCCACCCAGGCTGGTTTGTGAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAA
CTGGTTCGGAAAATAATTGGGGGAGTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAAT
ACAGTGAGCTCTGCTGTTGTACAGCAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCC
TATTTTGCAGTCACTGAGATCAGGAAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGAT
ACCTTCAGGCCCACAGCAAGGATAAACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCA
TGGAAACTGGATCCTGCTACTCTTCGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGATCTGTTTGAACCACAGACTGCTTTGTTG
AGATATGTATTGGAGCAGCCTTATTCCAGGGATATGGTCTGCAATATGCTAGGTTTAAATAAGCAGCACAAGCAGCGCTGCCCTGTGCTG
GAGGACCAGTTGGTGGATCTGGTTGTTTATGCCATGGAGCGATCTGAGACCGAGGAGAAGTTTGACGATGGGGGAACAAGCCAACTCCTG
TGGCAGCATCTCTCAAGTCAGCTCATTTTCTTTGTGCTTTTCCAGTTTGCAAGTTTTCCACATATGGTGCTTTCTCTTCATCAGAAGTTA
GCAGGGCGAGGACTGATTAAAGGCAGAGATCATCTTATGTGGGTTCTCCTGCAATTCATTTCTGGAAGTATTCAGAAAAATGCACTAGCT
GATTTTCTCCCTGTGATGAAGCTCTTCGACTTGCTATACCCAGAAAAAGAATATATCCCAGTTCCTGATATTAACAAACCCCAGTCAACC
CATGCCTTTGCAATGACCTGTATTTGGATTCATCTCAATAGAAAAGCTCAAAATGACAACTCCAAGCTACAGATTCCAATACCTCATTCC
CTAAGACTTCACCATGAGTTCCTGCAGCAGAGTCTAAGAAATAAAAGTTTACAGATGAATGACTATAAGATTGCTCTATTGTGTAATGCA
TACTCTACAAATTCAGAATGTTTTACATTACCCATGGGAGCTCTGGTAGAAACTATTTATGGAAATGGAATTATGAGGATACCTCTCCCT
GGAACAAACTGTATGGCTTCAGGATCTATTACCCCCTTACCTATGAACCTCCTGGATTCACTGACAGTTCATGCCAAAATGAGCCTTATT
CACAGCATTGCAACCAGGGTGATAAAACTTGCTCATGCAAAGTCCAGTGTGGCCTTGGCTCCAGCCCTAGTGGAAACTTACAGTCGTTTA
TTGGTCTATATGGAAATAGAGTCTTTGGGCATCAAAGGATTTATCAGTCAGCTTTTGCCAACTGTTTTCAAATCACATGCATGGGGGATC
TTACACACACTCCTTGAGATGTTTAGCTACCGGATGCATCATATTCAGCCTCATTACAGAGTTCAGCTCCTGAGTCATCTTCATACTTTG
GCTGCAGTTGCACAAACAAACCAGAACCAGCTCCATCTTTGTGTCGAGAGCACTGCTCTCAGGCTTATAACAGCATTAGGTAGCTCAGAG
GTACAACCGCAGTTTACACGCTTCCTTAGTGATCCCAAAACAGTGCTCTCAGCAGAATCTGAAGAACTGAACCGAGCCTTGATATTGACC
TTGGCTAGAGCAACTCATGTAACAGATTTTTTTACAGGCTCTGATTCAATTCAGGGAACTTGGTGTAAAGACATACTTCAGACCATCATG
AGTTTCACTCCTCATAATTGGGCTTCACACACCCTGAGCTGTTTTCCAGGCCCACTACAGGCATTCTTCAAACAAAATAATGTGCCTCAG
GAAAGCCGTTTTAATCTGAAAAAAAATGTGGAGGAGGAGTATAGGAAGTGGAAGTCAATGAGCAACGAAAACGACATTATTACCCACTTC
TCTATGCAGGGCTCCCCTCCTCTCTTTCTTTGTCTTCTCTGGAAAATGCTCTTGGAAACAGATCATATTAATCAGATTGGCTATAGAGTA
TTAGAGAGAATTGGAGCCAGGGCCTTGGTAGCCCATGTGAGGACATTTGCAGATTTCCTGGTATATGAGTTTTCTACATCAGCAGGGGGT
CAGCAACTCAATAAATGCATTGAAATTCTTAATGACATGGTATGGAAGTATAACATTGTTACACTGGACAGATTAATTCTCTGCCTGGCC
ATGCGTAGTCACGAAGGAAATGAAGCCCAGGTTTGTTATTTCATAATTCAGTTGCTGTTACTCAAACCAAACGATTTTAGAAATCGAGTA
AGTGACTTTGTGAAGGAAAATTCCCCAGAGCACTGGTTACAGAATGACTGGCACACCAAGCACATGAATTATCACAAGAAATATCCAGAG
AAGTTGTATTTTGAGGGCCTCGCGGAACAGGTGGATCCTCCTGTACAGATCCAGTCTCCCTATCTGCCCATCTATTTTGGGAATGTGTGT
CTTCGATTCCTTCCAGTATTTGATATAGTAATCCACAGATTTTTAGAGTTGCTTCCGGTATCCAAATCACTGGAGACTCTACTGGATCAT
CTAGGAGGCTTATATAAATTTCATGATCGTCCAGTGACTTATCTGTATAACACTCTGCACTATTATGAAATGCACCTGAGAGACCGCGCA
TTTCTCAAACGAAAACTCGTCCATGCGATCATTGGCTCTCTGAAGGATAATCGACCGCAGGGCTGGTGTCTAAGTGACACTTACCTGAAA
TGCGCTATGAATGCACGAGAGGAAAATCCTTGGGTTCCAGATGACACCTACTATTGCAGATTGATTGGCAGACTAGTCGATACGATGGCT
GGCAAATCTCCTGGTCCCTTTCCAAACTGTGACTGGAGATTCAATGAGTTTCCCAACCCAGCTGCCCATGCTCTCCATGTTACTTGTGTG
GAGCTCATGGCCTTGGCAGTTTCAGGCAAAGAAGTTGGGAATGCCCTTCTAAATGTTGTCCTAAAAAGTCAGCCTTTAGTGCCAAGAGAG
AACATTACAGCATGGATGAATGCAATTGGTTTGATCATCACTGCCCTACCAGAGCCATATTGGATTGTTCTTCATGATCGAATTGTGAGT
GTCATCAGCAGCCCCAGCTTGACGTCTGAAACAGAGTGGGTTGGCTATCCATTCCGCCTCTTTGATTTCACTGCCTGTCATCAGTCCTAC
TCTGAGATGAGTTGTAGCTATACGTTAGCTCTTGCACATGCTGTGTGGCACCATTCTAGCATCGGACAACTTTCTCTCATTCCAAAGTTT
CTTACTGAAGTACTTCTTCCTATAGTGAAGACCGAATTCCAGTTGCTTTATGTATACCATCTTGTTGGACCATTTTTACAAAGATTTCAG
CAAGAGAGAACTCGTTGTATGATAGAGATTGGTGTGGCGTTTTATGACATGCTGCTGAATGTTGACCAGTGTAGCACCCATTTAAATTAC
ATGGATCCCATCTGTGACTTCCTCTATCACATGAAGTATATGTTTACTGGTGACAGCGTGAAAGAGCAAGTAGAGAAGATTATCTGTAAC
TTAAAACCAGCTTTAAAACTTCGTCTTCGATTCATCACACACATTAGCAAGATGGAGCCAGCTGCAGTGCCTCCACAAGCCATGAACAGT
GGGTCTCCAGCACCTCAGTCTAATCAGGAACATTCCAGGCCTGAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAAGGAGAGCAACCAG
TCTGCTGTCCAGAAATTGGAAACAAACACGACGGAGTGTGGCGATGAGGATGATGAAGATAAACTGACCTGGAAGGATCGTTTCCCAGGT
TACCTGATGAACTTTGCCTCCATCTTATTCATGATTGCCCTGACATTCTCAATCGTCTTTGGGGTGATAGTGTATCGAATAACAACTGCA
GCCGCTCTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGGGTGACAGTGACAGCAACAGCAGTCATCATCAACCTCGTGGTCATCCTC
ATCCTGGACGAGATCTACGGCGCTGTGGCCAAGTGGCTCACCAAAATTGAGGTTCCGAAAACAGAACAGACTTTTGAAGAGCGCCTGATC
CTCAAAGCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCCATCTTCTATGTGGCCTTTTTCAAAGGGAGGTTTGTGGGCAGGCCTGGA
AGCTACGTCTATGTATTCGATGGTTACCGCATGGAAGAGTGTGCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCAGCTCAGCATCATC
ATGTTGGGGAAGCAGTTGATCCAGAACAACATCTTTGAGATTGGAGTCCCGAAGCTAAAGAAACTATTTCGAAAGCTGAAAGATGAGACC
GAAGCTGGAGAAACTGACTCTGCCCATTCGAAACATCCAGAGCAGTGGGACCTAGACTACAGCTTGGAACCATACACAGGACTGACTCCG
GAGTACATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTCTTCGTGGCCTCCTTTCCCCTGGCACCTGTGTTTGCCCTCCTCAACAAC
GTCATTGAAGTGCGGCTCGATGCAAAGAAGTTTGTTACAGAGCTGAGACGGCCGGATGCTGTAAGAACCAAAGATATCGGAATCTGGTTT
GACATTCTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAACGCTTTTGTCATTGCGATCACCTCCGACTTTATCCCCCGCCTGGTGTAC
CAGTACTCCTACAGTCACAATGGGACTCTGCACGGCTTTGTCAACCACACCCTCTCCTTTTTCAACGTCAGCCAGCTGAAGGAGGGGACG
CAGCCAGAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGCAGGTTTAAGGATTACCGAGAGCCGCCATGGGCCCCGAACCCTTATGAG
TTTTCGAAACAGTACTGGTTTATTCTGTCCGCCCGTCTGGCTTTTGTCATAATCTTCCAGAACCTCGTGATGTTCCTGAGCGTCCTCGTG
GACTGGATGATTCCAGACATCCCCACGGACATCAGCGACCAGATCAAGAAAGAGAAGAGCTTATTAGTGGATTTCTTCCTGAAAGAGGAG
CATGAGAAGCTCAAGCTGATGGATGAGCCGGCTCTGAGGAGCCCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGCCAGCTCAGCACCT
TCAGGCCAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCTCAGCACACCAATGTGTGAGCAGTTCAGCCTGCAGCAGAGGAGGGCACG
GCAGCAGAGACACGCACATGCACGTAAGCATGTTCCTACACCCACATGGCGTGCTGTCTGTCTGCAGGGGCCTGGCTTGATGGGGTCTTG
AAGAGGGGGCAGTGTGTAAAAAGAAAGAGCCTGACAGAATGAGTGTAGGAAGGAAGAGAAATGATGCTACATCTCAGAAACTTCAAGCTT
AAGTTTCTTTTAGGTCCCCTTTTAAGCTGCATCCTTTTGAGGGATTGGAACCCCACTGGGGTCTCTCCACCCCAGAGTCTCAGGCACCGC
GAGCATTCCCATGTACCCTGGGGCACCCTCTTGTACTTCACCATCATTTCTGACTTTGACCAGCTGTAAGAGAAATGCAGTCAGGAGCAC
AGCATCCCCTACTTACTATCACTACAAGAAAACTGAGTCACTTGCAGTGGGGCTGCCACAGTCTCAGCAGATGCAAATTAAGTTACAAGG
CTGAATGGTGCAGCCGCTGGACCTGATAGTAAGGTGCAAAGGTCCAAACCTGGGCTTGTCTCCACTTCACGTCACAAAAACGTTTGGAGC

>In-frame_ENST00000368060_ENST00000546188_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(amino acids)=1879AA_start in transcript=180_stop in transcript=5819
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALL
RYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKL
AGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHS
LRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLI
HSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTL
AAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIM
SFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRV
LERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRV
SDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDH
LGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMA
GKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVS
VISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQ
QERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMNS
GSPAPQSNQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTA
AALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPG
SYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTGLTP
EYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVY
QYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLV

--------------------------------------------------------------
>In-frame_ENST00000368060_ENST00000356134_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(transcript)=6465nt_BP=4257nt
GTTCCTGCTGTTGGCTGGGCTCGGGAGGGAACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGA
GGTCTCCGCCCCTCTGCCCCTATATTCCCAGAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAG
ATGGAGACGCAACTGCAGAGCATTTTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCT
GAAGATGAGAAAACAAAACTAATTAGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATC
CAGTGGATTGTTAAGTTTATTCATGGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGT
CTCCTTCCACCCAGGCTGGTTTGTGAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAA
CTGGTTCGGAAAATAATTGGGGGAGTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAAT
ACAGTGAGCTCTGCTGTTGTACAGCAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCC
TATTTTGCAGTCACTGAGATCAGGAAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGAT
ACCTTCAGGCCCACAGCAAGGATAAACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCA
TGGAAACTGGATCCTGCTACTCTTCGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGATCTGTTTGAACCACAGACTGCTTTGTTG
AGATATGTATTGGAGCAGCCTTATTCCAGGGATATGGTCTGCAATATGCTAGGTTTAAATAAGCAGCACAAGCAGCGCTGCCCTGTGCTG
GAGGACCAGTTGGTGGATCTGGTTGTTTATGCCATGGAGCGATCTGAGACCGAGGAGAAGTTTGACGATGGGGGAACAAGCCAACTCCTG
TGGCAGCATCTCTCAAGTCAGCTCATTTTCTTTGTGCTTTTCCAGTTTGCAAGTTTTCCACATATGGTGCTTTCTCTTCATCAGAAGTTA
GCAGGGCGAGGACTGATTAAAGGCAGAGATCATCTTATGTGGGTTCTCCTGCAATTCATTTCTGGAAGTATTCAGAAAAATGCACTAGCT
GATTTTCTCCCTGTGATGAAGCTCTTCGACTTGCTATACCCAGAAAAAGAATATATCCCAGTTCCTGATATTAACAAACCCCAGTCAACC
CATGCCTTTGCAATGACCTGTATTTGGATTCATCTCAATAGAAAAGCTCAAAATGACAACTCCAAGCTACAGATTCCAATACCTCATTCC
CTAAGACTTCACCATGAGTTCCTGCAGCAGAGTCTAAGAAATAAAAGTTTACAGATGAATGACTATAAGATTGCTCTATTGTGTAATGCA
TACTCTACAAATTCAGAATGTTTTACATTACCCATGGGAGCTCTGGTAGAAACTATTTATGGAAATGGAATTATGAGGATACCTCTCCCT
GGAACAAACTGTATGGCTTCAGGATCTATTACCCCCTTACCTATGAACCTCCTGGATTCACTGACAGTTCATGCCAAAATGAGCCTTATT
CACAGCATTGCAACCAGGGTGATAAAACTTGCTCATGCAAAGTCCAGTGTGGCCTTGGCTCCAGCCCTAGTGGAAACTTACAGTCGTTTA
TTGGTCTATATGGAAATAGAGTCTTTGGGCATCAAAGGATTTATCAGTCAGCTTTTGCCAACTGTTTTCAAATCACATGCATGGGGGATC
TTACACACACTCCTTGAGATGTTTAGCTACCGGATGCATCATATTCAGCCTCATTACAGAGTTCAGCTCCTGAGTCATCTTCATACTTTG
GCTGCAGTTGCACAAACAAACCAGAACCAGCTCCATCTTTGTGTCGAGAGCACTGCTCTCAGGCTTATAACAGCATTAGGTAGCTCAGAG
GTACAACCGCAGTTTACACGCTTCCTTAGTGATCCCAAAACAGTGCTCTCAGCAGAATCTGAAGAACTGAACCGAGCCTTGATATTGACC
TTGGCTAGAGCAACTCATGTAACAGATTTTTTTACAGGCTCTGATTCAATTCAGGGAACTTGGTGTAAAGACATACTTCAGACCATCATG
AGTTTCACTCCTCATAATTGGGCTTCACACACCCTGAGCTGTTTTCCAGGCCCACTACAGGCATTCTTCAAACAAAATAATGTGCCTCAG
GAAAGCCGTTTTAATCTGAAAAAAAATGTGGAGGAGGAGTATAGGAAGTGGAAGTCAATGAGCAACGAAAACGACATTATTACCCACTTC
TCTATGCAGGGCTCCCCTCCTCTCTTTCTTTGTCTTCTCTGGAAAATGCTCTTGGAAACAGATCATATTAATCAGATTGGCTATAGAGTA
TTAGAGAGAATTGGAGCCAGGGCCTTGGTAGCCCATGTGAGGACATTTGCAGATTTCCTGGTATATGAGTTTTCTACATCAGCAGGGGGT
CAGCAACTCAATAAATGCATTGAAATTCTTAATGACATGGTATGGAAGTATAACATTGTTACACTGGACAGATTAATTCTCTGCCTGGCC
ATGCGTAGTCACGAAGGAAATGAAGCCCAGGTTTGTTATTTCATAATTCAGTTGCTGTTACTCAAACCAAACGATTTTAGAAATCGAGTA
AGTGACTTTGTGAAGGAAAATTCCCCAGAGCACTGGTTACAGAATGACTGGCACACCAAGCACATGAATTATCACAAGAAATATCCAGAG
AAGTTGTATTTTGAGGGCCTCGCGGAACAGGTGGATCCTCCTGTACAGATCCAGTCTCCCTATCTGCCCATCTATTTTGGGAATGTGTGT
CTTCGATTCCTTCCAGTATTTGATATAGTAATCCACAGATTTTTAGAGTTGCTTCCGGTATCCAAATCACTGGAGACTCTACTGGATCAT
CTAGGAGGCTTATATAAATTTCATGATCGTCCAGTGACTTATCTGTATAACACTCTGCACTATTATGAAATGCACCTGAGAGACCGCGCA
TTTCTCAAACGAAAACTCGTCCATGCGATCATTGGCTCTCTGAAGGATAATCGACCGCAGGGCTGGTGTCTAAGTGACACTTACCTGAAA
TGCGCTATGAATGCACGAGAGGAAAATCCTTGGGTTCCAGATGACACCTACTATTGCAGATTGATTGGCAGACTAGTCGATACGATGGCT
GGCAAATCTCCTGGTCCCTTTCCAAACTGTGACTGGAGATTCAATGAGTTTCCCAACCCAGCTGCCCATGCTCTCCATGTTACTTGTGTG
GAGCTCATGGCCTTGGCAGTTTCAGGCAAAGAAGTTGGGAATGCCCTTCTAAATGTTGTCCTAAAAAGTCAGCCTTTAGTGCCAAGAGAG
AACATTACAGCATGGATGAATGCAATTGGTTTGATCATCACTGCCCTACCAGAGCCATATTGGATTGTTCTTCATGATCGAATTGTGAGT
GTCATCAGCAGCCCCAGCTTGACGTCTGAAACAGAGTGGGTTGGCTATCCATTCCGCCTCTTTGATTTCACTGCCTGTCATCAGTCCTAC
TCTGAGATGAGTTGTAGCTATACGTTAGCTCTTGCACATGCTGTGTGGCACCATTCTAGCATCGGACAACTTTCTCTCATTCCAAAGTTT
CTTACTGAAGTACTTCTTCCTATAGTGAAGACCGAATTCCAGTTGCTTTATGTATACCATCTTGTTGGACCATTTTTACAAAGATTTCAG
CAAGAGAGAACTCGTTGTATGATAGAGATTGGTGTGGCGTTTTATGACATGCTGCTGAATGTTGACCAGTGTAGCACCCATTTAAATTAC
ATGGATCCCATCTGTGACTTCCTCTATCACATGAAGTATATGTTTACTGGTGACAGCGTGAAAGAGCAAGTAGAGAAGATTATCTGTAAC
TTAAAACCAGCTTTAAAACTTCGTCTTCGATTCATCACACACATTAGCAAGATGGAGCCAGCTGCAGTGCCTCCACAAGCCATGAACAGT
GGGTCTCCAGCACCTCAGTCTAATCAGGAACATTCCAGGCCTGAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAAGGAGAGCAACCAG
TCTGCTGTCCAGAAATTGGAAACAAACACGACGGAGTGTGGCGATGAGGATGATGAAGATAAACTGACCTGGAAGGATCGTTTCCCAGGT
TACCTGATGAACTTTGCCTCCATCTTATTCATGATTGCCCTGACATTCTCAATCGTCTTTGGGGTGATAGTGTATCGAATAACAACTGCA
GCCGCTCTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGGGTGACAGTGACAGCAACAGCAGTCATCATCAACCTCGTGGTCATCCTC
ATCCTGGACGAGATCTACGGCGCTGTGGCCAAGTGGCTCACCAAAATTGAGGTTCCGAAAACAGAACAGACTTTTGAAGAGCGCCTGATC
CTCAAAGCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCCATCTTCTATGTGGCCTTTTTCAAAGGGAGGTTTGTGGGCAGGCCTGGA
AGCTACGTCTATGTATTCGATGGTTACCGCATGGAAGAGTGTGCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCAGCTCAGCATCATC
ATGTTGGGGAAGCAGTTGATCCAGAACAACATCTTTGAGATTGGAGTCCCGAAGCTAAAGAAACTATTTCGAAAGCTGAAAGATGAGACC
GAAGCTGGAGAAACTGACTCTGCCCATTCGAAACATCCAGAGCAGTGGGACCTAGACTACAGCTTGGAACCATACACAGGACTGACTCCG
GAGTACATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTCTTCGTGGCCTCCTTTCCCCTGGCACCTGTGTTTGCCCTCCTCAACAAC
GTCATTGAAGTGCGGCTCGATGCAAAGAAGTTTGTTACAGAGCTGAGACGGCCGGATGCTGTAAGAACCAAAGATATCGGAATCTGGTTT
GACATTCTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAACGCTTTTGTCATTGCGATCACCTCCGACTTTATCCCCCGCCTGGTGTAC
CAGTACTCCTACAGTCACAATGGGACTCTGCACGGCTTTGTCAACCACACCCTCTCCTTTTTCAACGTCAGCCAGCTGAAGGAGGGGACG
CAGCCAGAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGCAGGTTTAAGGATTACCGAGAGCCGCCATGGGCCCCGAACCCTTATGAG
TTTTCGAAACAGTACTGGTTTATTCTGTCCGCCCGTCTGGCTTTTGTCATAATCTTCCAGAACCTCGTGATGTTCCTGAGCGTCCTCGTG
GACTGGATGATTCCAGACATCCCCACGGACATCAGCGACCAGATCAAGAAAGAGAAGAGCTTATTAGTGGATTTCTTCCTGAAAGAGGAG
CATGAGAAGCTCAAGCTGATGGATGAGCCGGCTCTGAGGAGCCCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGCCAGCTCAGCACCT
TCAGGCCAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCTCAGCACACCAATGTGTGAGCAGTTCAGCCTGCAGCAGAGGAGGGCACG
GCAGCAGAGACACGCACATGCACGTAAGCATGTTCCTACACCCACATGGCGTGCTGTCTGTCTGCAGGGGCCTGGCTTGATGGGGTCTTG
AAGAGGGGGCAGTGTGTAAAAAGAAAGAGCCTGACAGAATGAGTGTAGGAAGGAAGAGAAATGATGCTACATCTCAGAAACTTCAAGCTT
AAGTTTCTTTTAGGTCCCCTTTTAAGCTGCATCCTTTTGAGGGATTGGAACCCCACTGGGGTCTCTCCACCCCAGAGTCTCAGGCACCGC
GAGCATTCCCATGTACCCTGGGGCACCCTCTTGTACTTCACCATCATTTCTGACTTTGACCAGCTGTAAGAGAAATGCAGTCAGGAGCAC
AGCATCCCCTACTTACTATCACTACAAGAAAACTGAGTCACTTGCAGTGGGGCTGCCACAGTCTCAGCAGATGCAAATTAAGTTACAAGG
CTGAATGGTGCAGCCGCTGGACCTGATAGTAAGGTGCAAAGGTCCAAACCTGGGCTTGTCTCCACTTCACGTCACAAAAACGTTTGGAGC

>In-frame_ENST00000368060_ENST00000356134_TCGA-Q1-A5R2-01A_MED23_chr6_131908849_-_ANO2_chr12_5841796_length(amino acids)=1879AA_start in transcript=180_stop in transcript=5819
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALL
RYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKL
AGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHS
LRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLI
HSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTL
AAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIM
SFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRV
LERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRV
SDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDH
LGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMA
GKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVS
VISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQ
QERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMNS
GSPAPQSNQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTA
AALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPG
SYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTGLTP
EYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVY
QYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MED23-ANO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED23-ANO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED23-ANO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMED23C3280265MENTAL RETARDATION, AUTOSOMAL RECESSIVE 182CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneMED23C3714756Intellectual Disability1GENOMICS_ENGLAND