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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED23-KLHL32 (FusionGDB2 ID:52387)

Fusion Gene Summary for MED23-KLHL32

check button Fusion gene summary
Fusion gene informationFusion gene name: MED23-KLHL32
Fusion gene ID: 52387
HgeneTgene
Gene symbol

MED23

KLHL32

Gene ID

9439

114792

Gene namemediator complex subunit 23kelch like family member 32
SynonymsARC130|CRSP130|CRSP133|CRSP3|DRIP130|MRT18|SUR-2|SUR2BKLHD5|KIAA1900|UG0030H05|dJ21F7.1
Cytomap

6q23.2

6q16.1

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 23130 kDa transcriptional co-activator133 kDa transcriptional co-activatoractivator-recruited cofactor 130 kDa componentcofactor required for Sp1 transcriptional activation subunit 3mental retardatikelch-like protein 32BTB and kelch domain containing 5
Modification date2020031320200313
UniProtAcc

Q9ULK4

Q96NJ5

Ensembl transtripts involved in fusion geneENST00000354577, ENST00000403834, 
ENST00000368068, ENST00000479213, 
ENST00000368060, ENST00000368058, 
ENST00000545957, ENST00000368053, 
ENST00000540546, ENST00000539158, 
ENST00000369261, ENST00000536676, 
ENST00000544166, ENST00000539200, 
Fusion gene scores* DoF score6 X 8 X 4=1924 X 3 X 4=48
# samples 95
** MAII scorelog2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MED23 [Title/Abstract] AND KLHL32 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED23(131939547)-KLHL32(97489368), # samples:3
Anticipated loss of major functional domain due to fusion event.MED23-KLHL32 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MED23-KLHL32 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED23

GO:0006355

regulation of transcription, DNA-templated

9989412


check buttonFusion gene breakpoints across MED23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KLHL32 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TW-01AMED23chr6

131939547

-KLHL32chr6

97489368

+
ChimerDB4BRCATCGA-AR-A0TW-01AMED23chr6

131939547

-KLHL32chr6

97489368

+
ChimerDB4BRCATCGA-AR-A0TW-01AMED23chr6

131939547

-KLHL32chr6

97489368

+


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Fusion Gene ORF analysis for MED23-KLHL32

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000354577ENST00000369261MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000354577ENST00000536676MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-5UTRENST00000354577ENST00000544166MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000354577ENST00000539200MED23chr6

131939547

-KLHL32chr6

97489368

+
In-frameENST00000403834ENST00000369261MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000403834ENST00000536676MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-5UTRENST00000403834ENST00000544166MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000403834ENST00000539200MED23chr6

131939547

-KLHL32chr6

97489368

+
In-frameENST00000368068ENST00000369261MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000368068ENST00000536676MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-5UTRENST00000368068ENST00000544166MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000368068ENST00000539200MED23chr6

131939547

-KLHL32chr6

97489368

+
intron-3CDSENST00000479213ENST00000369261MED23chr6

131939547

-KLHL32chr6

97489368

+
intron-intronENST00000479213ENST00000536676MED23chr6

131939547

-KLHL32chr6

97489368

+
intron-5UTRENST00000479213ENST00000544166MED23chr6

131939547

-KLHL32chr6

97489368

+
intron-intronENST00000479213ENST00000539200MED23chr6

131939547

-KLHL32chr6

97489368

+
In-frameENST00000368060ENST00000369261MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000368060ENST00000536676MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-5UTRENST00000368060ENST00000544166MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000368060ENST00000539200MED23chr6

131939547

-KLHL32chr6

97489368

+
In-frameENST00000368058ENST00000369261MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000368058ENST00000536676MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-5UTRENST00000368058ENST00000544166MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000368058ENST00000539200MED23chr6

131939547

-KLHL32chr6

97489368

+
intron-3CDSENST00000545957ENST00000369261MED23chr6

131939547

-KLHL32chr6

97489368

+
intron-intronENST00000545957ENST00000536676MED23chr6

131939547

-KLHL32chr6

97489368

+
intron-5UTRENST00000545957ENST00000544166MED23chr6

131939547

-KLHL32chr6

97489368

+
intron-intronENST00000545957ENST00000539200MED23chr6

131939547

-KLHL32chr6

97489368

+
In-frameENST00000368053ENST00000369261MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000368053ENST00000536676MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-5UTRENST00000368053ENST00000544166MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000368053ENST00000539200MED23chr6

131939547

-KLHL32chr6

97489368

+
In-frameENST00000540546ENST00000369261MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000540546ENST00000536676MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-5UTRENST00000540546ENST00000544166MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000540546ENST00000539200MED23chr6

131939547

-KLHL32chr6

97489368

+
Frame-shiftENST00000539158ENST00000369261MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000539158ENST00000536676MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-5UTRENST00000539158ENST00000544166MED23chr6

131939547

-KLHL32chr6

97489368

+
5CDS-intronENST00000539158ENST00000539200MED23chr6

131939547

-KLHL32chr6

97489368

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354577MED23chr6131939547-ENST00000369261KLHL32chr697489368+40679361562594812
ENST00000403834MED23chr6131939547-ENST00000369261KLHL32chr697489368+40859541742612812
ENST00000368068MED23chr6131939547-ENST00000369261KLHL32chr697489368+40919601802618812
ENST00000368060MED23chr6131939547-ENST00000369261KLHL32chr697489368+40919601802618812
ENST00000368058MED23chr6131939547-ENST00000369261KLHL32chr697489368+3928797172455812
ENST00000368053MED23chr6131939547-ENST00000369261KLHL32chr697489368+40619301502588812
ENST00000540546MED23chr6131939547-ENST00000369261KLHL32chr697489368+40859541742612812

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354577ENST00000369261MED23chr6131939547-KLHL32chr697489368+0.0002453060.9997547
ENST00000403834ENST00000369261MED23chr6131939547-KLHL32chr697489368+0.0002465970.9997534
ENST00000368068ENST00000369261MED23chr6131939547-KLHL32chr697489368+0.0002466740.9997533
ENST00000368060ENST00000369261MED23chr6131939547-KLHL32chr697489368+0.0002466740.9997533
ENST00000368058ENST00000369261MED23chr6131939547-KLHL32chr697489368+0.000237880.9997621
ENST00000368053ENST00000369261MED23chr6131939547-KLHL32chr697489368+0.0002439920.99975604
ENST00000540546ENST00000369261MED23chr6131939547-KLHL32chr697489368+0.0002465970.9997534

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Fusion Genomic Features for MED23-KLHL32


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED23-KLHL32


check button Go to

FGviewer for the breakpoints of chr6:131939547-chr6:97489368

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED23

Q9ULK4

KLHL32

Q96NJ5

FUNCTION: Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269|PubMed:10353252, ECO:0000269|PubMed:14759369, ECO:0000269|PubMed:16595664}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKLHL32chr6:131939547chr6:97489368ENST00000369261211290_34668.0621.0RepeatNote=Kelch 1
TgeneKLHL32chr6:131939547chr6:97489368ENST00000369261211347_39868.0621.0RepeatNote=Kelch 2
TgeneKLHL32chr6:131939547chr6:97489368ENST00000369261211399_44668.0621.0RepeatNote=Kelch 3
TgeneKLHL32chr6:131939547chr6:97489368ENST00000369261211447_49468.0621.0RepeatNote=Kelch 4
TgeneKLHL32chr6:131939547chr6:97489368ENST00000369261211496_54768.0621.0RepeatNote=Kelch 5
TgeneKLHL32chr6:131939547chr6:97489368ENST00000369261211549_59968.0621.0RepeatNote=Kelch 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKLHL32chr6:131939547chr6:97489368ENST0000036926121142_10968.0621.0DomainBTB


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Fusion Gene Sequence for MED23-KLHL32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000354577_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(transcript)=4067nt_BP=936nt
GAGGGAACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGAGGTCTCCGCCCCTCTGCCCCTATA
TTCCCAGAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAGATGGAGACGCAACTGCAGAGCATT
TTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCTGAAGATGAGAAAACAAAACTAATT
AGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATCCAGTGGATTGTTAAGTTTATTCAT
GGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGTCTCCTTCCACCCAGGCTGGTTTGT
GAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAACTGGTTCGGAAAATAATTGGGGGA
GTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAATACAGTGAGCTCTGCTGTTGTACAG
CAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCCTATTTTGCAGTCACTGAGATCAGG
AAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGATACCTTCAGGCCCACAGCAAGGATA
AACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCATGGAAACTGGATCCTGCTACTCTT
CGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGCAATGTTCAGTCTTTGTATGGTGGAAAGTGGAGCTGATGAGGTTAATTTGCAC
GGTGTGACCAGCCTTGGCTTAAAGCAGGCTCTGGAGTTTGCATACACAGGACAGATTTTGCTGGAGCCAGGTGTGATCCAGGATGTGCTA
GCAGCGGGCAGTCACCTACAGCTGTTGGAGCTTCTCAATTTATGCTCCCACTATCTCATCCAGGAATTAAATAGCTTTAATTACTTGGAT
CTGTACAGACTTGCTGACCTCTTTAACCTCACTTTGTTGGAGAAGGCAGTGATCGATTTCTTAGTGAAACATCTCTCTGAACTCCTGAAG
AGCCGCCCAGAAGAAGTTCTAACGCTTCCCTATTGCCTGCTTCAGGAGGTGCTGAAGAGCGACCGCCTGACCTCCCTGAGTGAAGAGCAG
ATCTGGCAGCTAGCTGTGAGGTGGTTGGAACACAACTGCCACTACCAGTACATGGACGAGCTCCTGCAATACATCCGCTTTGGCCTAATG
GATGTGGATACTCTCCATACAGTTGCCCTGTCCCACCCCCTTGTCCAAGCAAGTGAGACTGCAACAGCCCTTGTCAACGAGGCCCTGGAA
TACCACCAGAGCATCTATGCACAGCCTGTCTGGCAGACTCGCAGGACCAAACCACGATTCCAGTCAGACACTCTGTATATCATTGGTGGG
AAAAAGCGCGAGGTCTGCAAGGTCAAGGAACTTCGGTACTTCAATCCTGTTGATCAGGAGAATGCTCTCATAGCTGCCATTGCCAACTGG
AGTGAGCTGGCTCCCATGCCTGTGGGAAGGAGCCACCATTGTGTGGCAGTCATGGGGGACTTCCTGTTTGTGGCAGGAGGGGAAGTTGAG
CATGCCAGTGGCCGGACGTGTGCTGTGAGGACTGCCTGTCGCTATGACCCCCGCAGTAATTCCTGGGCAGAGATAGCACCCATGAAAAAC
TGCCGGGAGCATTTTGTGCTGGGTGCCATGGAGGAATACCTCTATGCAGTTGGGGGCAGAAATGAACTGCGCCAGGTTCTGCCTACAGTT
GAGCGATATTGCCCCAAGAAGAACAAATGGACTTTTGTTCAGTCCTTTGACAGATCCCTTTCATGCCATGCTGGATATGTGGCTGATGGT
CTTCTTTGGATATCAGGTGGAGTAACTAATACGGCACAATATCAGAACAGGCTAATGGTGTATGAACCTAACCAGAATAAGTGGATAAGC
CGTAGCCCCATGCTGCAGAGAAGGGTCTACCATTCCATGGCTGCTGTACAAAGGAAGCTTTATGTTCTTGGAGGCAATGACCTAGACTAC
AATAATGACCGGATCCTTGTGCGCCATATAGATTCTTACAACATAGACACTGACCAGTGGACACGTTGTAATTTCAACCTGCTGACTGGC
CAAAATGAATCTGGAGTTGCTGTCCATAATGGGAGAATATATTTAGTTGGTGGATATTCAATTTGGACAAATGAGCCTCTGGCTTGTATC
CAGGTACTGGATGTAAGCAGAGAAGGCAAAGAAGAAGTATTCTATGGGCCTACACTCCCTTTTGCTTCCAATGGAATAGCAGCATGCTTC
CTTCCAGCTCCATATTTTACATGCCCTAACCTTCAAACTCTTCAAGTGCCTCATCACAGGATTGGCACCATCTGAAAAGCCAAGCCATCA
TGAACAGGAGGAAAACATAGCTCTGACTGTTGGATACTGGGCATGAAAAGACTCAGTGCTCCATGCTTCCTTGTCTTGCTTTATAGGTCT
TATATTCGGATAAATTTAAGCAAAAAATGAACAATTTTCTAAAATACGTTATTGAAAACTCGTCACCCTTCTCAGTGTATGTCAACATTC
AATATGTATGACTTTTATTGTGGTATAGCTTAGTGCCAATTTAAGGTATATTGTGTTCCATGGGTCTTTAGAGCATTCTTTGTACACTTT
TTCTAATCAGCACTGTCTTAAGACAACATAACACTGTTAGTAAGGCAATTTATTGGACACAATGGCATCGATGATCTTAAAAATATATAT
ATTCTGTACTTAATCCCTTTATTATTTAAAGCCGGGCTTGTAATTTTTCTTTTTAAAATTTAACATTATGCAGCCCTGCTCAGTAGAGAC
TCACTCAGCATTATGACATCATAAATTTTTAAATGCCATATTTTATTCAAGGTGATACGAATAATAATAGACATACACTGGAACAGCAGT
TGTTGAAATACCCAGATTTTTCACCTTGGTTACTCTGACCTTGGGTCAGAACCTAACTTTACAGTGCTTCAGTTTTCCCACCTTTTAAGG
AGGATAATTACTGATTTCCACGTTAATTTAAAAGAACATTATGAGGATTAGGCGAACACTTTGTAATACTTTGCCCAAGAAAAAGAAAAA
TGTTGTTACTGAAATTATAAGGTATTTTATTGTCTTTAGAACCTTGTAATTGAACAGGGAGATTATTTTTGAAGTTTAAAAATTACTAGA
TAGAATTTGGAAACATGTTGTGGAATAAATGATTCTAAAAAGCATGTGAAAGAGACACACAATGAGGAAATAGGGAGTTTCTCAAAATCT
AAACTTGTACAGGTATCTAAACTTGCCTCAAGTAACTCTCAGATGTCTTATTTAAAATCATTTAGTGAAAAATGACATTTAAAGCTAAAA
AATAATTTAGTTGTACTAATTATGGTACCATAAAGTGCTTTGACATAAATTTGAACCTAGAATTGGCAGTTCTAATAAAAGTTTTTCCAC
TTTGTTAAAGGTTATGTCAATCTTGAGTGCTTGTGGAATTCTTCACCACCAATACATATTTTATTACTATCTCTTTTAATAATGCATAGG
AATTCTTTTTTAGACTAGTTTTTGGGTTTGCTTTGTCTATAACAAAAAATAAATACAACAACTTAATAATCACATTTGAAAACAAATTTA
ACAAGTATAATGTGAGTTTTTCTTTTTTCCTAACTTCCTCAGGACCTAGGTCACCTTTATTAAAAGGAAGAATTCACTCTTTTTTCCTTG
GCAGTTTAATCATTCAGGAATCCCTCTCTTAAAGGAAATTGTTATTTTATTCATGTAACCTTTTTTTGTAATCAAAAGTGAATAAAAACG

>In-frame_ENST00000354577_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(amino acids)=812AA_start in transcript=156_stop in transcript=2594
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKAMFSLCMVES
GADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLV
KHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETAT
ALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFL
FVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSC
HAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTR
CNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAPYFTCPNLQTLQVPHHRIG

--------------------------------------------------------------
>In-frame_ENST00000403834_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(transcript)=4085nt_BP=954nt
GCTGTTGGCTGGGCTCGGGAGGGAACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGAGGTCTC
CGCCCCTCTGCCCCTATATTCCCAGAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAGATGGAG
ACGCAACTGCAGAGCATTTTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCTGAAGAT
GAGAAAACAAAACTAATTAGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATCCAGTGG
ATTGTTAAGTTTATTCATGGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGTCTCCTT
CCACCCAGGCTGGTTTGTGAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAACTGGTT
CGGAAAATAATTGGGGGAGTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAATACAGTG
AGCTCTGCTGTTGTACAGCAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCCTATTTT
GCAGTCACTGAGATCAGGAAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGATACCTTC
AGGCCCACAGCAAGGATAAACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCATGGAAA
CTGGATCCTGCTACTCTTCGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGCAATGTTCAGTCTTTGTATGGTGGAAAGTGGAGCT
GATGAGGTTAATTTGCACGGTGTGACCAGCCTTGGCTTAAAGCAGGCTCTGGAGTTTGCATACACAGGACAGATTTTGCTGGAGCCAGGT
GTGATCCAGGATGTGCTAGCAGCGGGCAGTCACCTACAGCTGTTGGAGCTTCTCAATTTATGCTCCCACTATCTCATCCAGGAATTAAAT
AGCTTTAATTACTTGGATCTGTACAGACTTGCTGACCTCTTTAACCTCACTTTGTTGGAGAAGGCAGTGATCGATTTCTTAGTGAAACAT
CTCTCTGAACTCCTGAAGAGCCGCCCAGAAGAAGTTCTAACGCTTCCCTATTGCCTGCTTCAGGAGGTGCTGAAGAGCGACCGCCTGACC
TCCCTGAGTGAAGAGCAGATCTGGCAGCTAGCTGTGAGGTGGTTGGAACACAACTGCCACTACCAGTACATGGACGAGCTCCTGCAATAC
ATCCGCTTTGGCCTAATGGATGTGGATACTCTCCATACAGTTGCCCTGTCCCACCCCCTTGTCCAAGCAAGTGAGACTGCAACAGCCCTT
GTCAACGAGGCCCTGGAATACCACCAGAGCATCTATGCACAGCCTGTCTGGCAGACTCGCAGGACCAAACCACGATTCCAGTCAGACACT
CTGTATATCATTGGTGGGAAAAAGCGCGAGGTCTGCAAGGTCAAGGAACTTCGGTACTTCAATCCTGTTGATCAGGAGAATGCTCTCATA
GCTGCCATTGCCAACTGGAGTGAGCTGGCTCCCATGCCTGTGGGAAGGAGCCACCATTGTGTGGCAGTCATGGGGGACTTCCTGTTTGTG
GCAGGAGGGGAAGTTGAGCATGCCAGTGGCCGGACGTGTGCTGTGAGGACTGCCTGTCGCTATGACCCCCGCAGTAATTCCTGGGCAGAG
ATAGCACCCATGAAAAACTGCCGGGAGCATTTTGTGCTGGGTGCCATGGAGGAATACCTCTATGCAGTTGGGGGCAGAAATGAACTGCGC
CAGGTTCTGCCTACAGTTGAGCGATATTGCCCCAAGAAGAACAAATGGACTTTTGTTCAGTCCTTTGACAGATCCCTTTCATGCCATGCT
GGATATGTGGCTGATGGTCTTCTTTGGATATCAGGTGGAGTAACTAATACGGCACAATATCAGAACAGGCTAATGGTGTATGAACCTAAC
CAGAATAAGTGGATAAGCCGTAGCCCCATGCTGCAGAGAAGGGTCTACCATTCCATGGCTGCTGTACAAAGGAAGCTTTATGTTCTTGGA
GGCAATGACCTAGACTACAATAATGACCGGATCCTTGTGCGCCATATAGATTCTTACAACATAGACACTGACCAGTGGACACGTTGTAAT
TTCAACCTGCTGACTGGCCAAAATGAATCTGGAGTTGCTGTCCATAATGGGAGAATATATTTAGTTGGTGGATATTCAATTTGGACAAAT
GAGCCTCTGGCTTGTATCCAGGTACTGGATGTAAGCAGAGAAGGCAAAGAAGAAGTATTCTATGGGCCTACACTCCCTTTTGCTTCCAAT
GGAATAGCAGCATGCTTCCTTCCAGCTCCATATTTTACATGCCCTAACCTTCAAACTCTTCAAGTGCCTCATCACAGGATTGGCACCATC
TGAAAAGCCAAGCCATCATGAACAGGAGGAAAACATAGCTCTGACTGTTGGATACTGGGCATGAAAAGACTCAGTGCTCCATGCTTCCTT
GTCTTGCTTTATAGGTCTTATATTCGGATAAATTTAAGCAAAAAATGAACAATTTTCTAAAATACGTTATTGAAAACTCGTCACCCTTCT
CAGTGTATGTCAACATTCAATATGTATGACTTTTATTGTGGTATAGCTTAGTGCCAATTTAAGGTATATTGTGTTCCATGGGTCTTTAGA
GCATTCTTTGTACACTTTTTCTAATCAGCACTGTCTTAAGACAACATAACACTGTTAGTAAGGCAATTTATTGGACACAATGGCATCGAT
GATCTTAAAAATATATATATTCTGTACTTAATCCCTTTATTATTTAAAGCCGGGCTTGTAATTTTTCTTTTTAAAATTTAACATTATGCA
GCCCTGCTCAGTAGAGACTCACTCAGCATTATGACATCATAAATTTTTAAATGCCATATTTTATTCAAGGTGATACGAATAATAATAGAC
ATACACTGGAACAGCAGTTGTTGAAATACCCAGATTTTTCACCTTGGTTACTCTGACCTTGGGTCAGAACCTAACTTTACAGTGCTTCAG
TTTTCCCACCTTTTAAGGAGGATAATTACTGATTTCCACGTTAATTTAAAAGAACATTATGAGGATTAGGCGAACACTTTGTAATACTTT
GCCCAAGAAAAAGAAAAATGTTGTTACTGAAATTATAAGGTATTTTATTGTCTTTAGAACCTTGTAATTGAACAGGGAGATTATTTTTGA
AGTTTAAAAATTACTAGATAGAATTTGGAAACATGTTGTGGAATAAATGATTCTAAAAAGCATGTGAAAGAGACACACAATGAGGAAATA
GGGAGTTTCTCAAAATCTAAACTTGTACAGGTATCTAAACTTGCCTCAAGTAACTCTCAGATGTCTTATTTAAAATCATTTAGTGAAAAA
TGACATTTAAAGCTAAAAAATAATTTAGTTGTACTAATTATGGTACCATAAAGTGCTTTGACATAAATTTGAACCTAGAATTGGCAGTTC
TAATAAAAGTTTTTCCACTTTGTTAAAGGTTATGTCAATCTTGAGTGCTTGTGGAATTCTTCACCACCAATACATATTTTATTACTATCT
CTTTTAATAATGCATAGGAATTCTTTTTTAGACTAGTTTTTGGGTTTGCTTTGTCTATAACAAAAAATAAATACAACAACTTAATAATCA
CATTTGAAAACAAATTTAACAAGTATAATGTGAGTTTTTCTTTTTTCCTAACTTCCTCAGGACCTAGGTCACCTTTATTAAAAGGAAGAA
TTCACTCTTTTTTCCTTGGCAGTTTAATCATTCAGGAATCCCTCTCTTAAAGGAAATTGTTATTTTATTCATGTAACCTTTTTTTGTAAT

>In-frame_ENST00000403834_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(amino acids)=812AA_start in transcript=174_stop in transcript=2612
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKAMFSLCMVES
GADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLV
KHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETAT
ALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFL
FVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSC
HAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTR
CNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAPYFTCPNLQTLQVPHHRIG

--------------------------------------------------------------
>In-frame_ENST00000368068_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(transcript)=4091nt_BP=960nt
GTTCCTGCTGTTGGCTGGGCTCGGGAGGGAACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGA
GGTCTCCGCCCCTCTGCCCCTATATTCCCAGAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAG
ATGGAGACGCAACTGCAGAGCATTTTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCT
GAAGATGAGAAAACAAAACTAATTAGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATC
CAGTGGATTGTTAAGTTTATTCATGGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGT
CTCCTTCCACCCAGGCTGGTTTGTGAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAA
CTGGTTCGGAAAATAATTGGGGGAGTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAAT
ACAGTGAGCTCTGCTGTTGTACAGCAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCC
TATTTTGCAGTCACTGAGATCAGGAAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGAT
ACCTTCAGGCCCACAGCAAGGATAAACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCA
TGGAAACTGGATCCTGCTACTCTTCGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGCAATGTTCAGTCTTTGTATGGTGGAAAGT
GGAGCTGATGAGGTTAATTTGCACGGTGTGACCAGCCTTGGCTTAAAGCAGGCTCTGGAGTTTGCATACACAGGACAGATTTTGCTGGAG
CCAGGTGTGATCCAGGATGTGCTAGCAGCGGGCAGTCACCTACAGCTGTTGGAGCTTCTCAATTTATGCTCCCACTATCTCATCCAGGAA
TTAAATAGCTTTAATTACTTGGATCTGTACAGACTTGCTGACCTCTTTAACCTCACTTTGTTGGAGAAGGCAGTGATCGATTTCTTAGTG
AAACATCTCTCTGAACTCCTGAAGAGCCGCCCAGAAGAAGTTCTAACGCTTCCCTATTGCCTGCTTCAGGAGGTGCTGAAGAGCGACCGC
CTGACCTCCCTGAGTGAAGAGCAGATCTGGCAGCTAGCTGTGAGGTGGTTGGAACACAACTGCCACTACCAGTACATGGACGAGCTCCTG
CAATACATCCGCTTTGGCCTAATGGATGTGGATACTCTCCATACAGTTGCCCTGTCCCACCCCCTTGTCCAAGCAAGTGAGACTGCAACA
GCCCTTGTCAACGAGGCCCTGGAATACCACCAGAGCATCTATGCACAGCCTGTCTGGCAGACTCGCAGGACCAAACCACGATTCCAGTCA
GACACTCTGTATATCATTGGTGGGAAAAAGCGCGAGGTCTGCAAGGTCAAGGAACTTCGGTACTTCAATCCTGTTGATCAGGAGAATGCT
CTCATAGCTGCCATTGCCAACTGGAGTGAGCTGGCTCCCATGCCTGTGGGAAGGAGCCACCATTGTGTGGCAGTCATGGGGGACTTCCTG
TTTGTGGCAGGAGGGGAAGTTGAGCATGCCAGTGGCCGGACGTGTGCTGTGAGGACTGCCTGTCGCTATGACCCCCGCAGTAATTCCTGG
GCAGAGATAGCACCCATGAAAAACTGCCGGGAGCATTTTGTGCTGGGTGCCATGGAGGAATACCTCTATGCAGTTGGGGGCAGAAATGAA
CTGCGCCAGGTTCTGCCTACAGTTGAGCGATATTGCCCCAAGAAGAACAAATGGACTTTTGTTCAGTCCTTTGACAGATCCCTTTCATGC
CATGCTGGATATGTGGCTGATGGTCTTCTTTGGATATCAGGTGGAGTAACTAATACGGCACAATATCAGAACAGGCTAATGGTGTATGAA
CCTAACCAGAATAAGTGGATAAGCCGTAGCCCCATGCTGCAGAGAAGGGTCTACCATTCCATGGCTGCTGTACAAAGGAAGCTTTATGTT
CTTGGAGGCAATGACCTAGACTACAATAATGACCGGATCCTTGTGCGCCATATAGATTCTTACAACATAGACACTGACCAGTGGACACGT
TGTAATTTCAACCTGCTGACTGGCCAAAATGAATCTGGAGTTGCTGTCCATAATGGGAGAATATATTTAGTTGGTGGATATTCAATTTGG
ACAAATGAGCCTCTGGCTTGTATCCAGGTACTGGATGTAAGCAGAGAAGGCAAAGAAGAAGTATTCTATGGGCCTACACTCCCTTTTGCT
TCCAATGGAATAGCAGCATGCTTCCTTCCAGCTCCATATTTTACATGCCCTAACCTTCAAACTCTTCAAGTGCCTCATCACAGGATTGGC
ACCATCTGAAAAGCCAAGCCATCATGAACAGGAGGAAAACATAGCTCTGACTGTTGGATACTGGGCATGAAAAGACTCAGTGCTCCATGC
TTCCTTGTCTTGCTTTATAGGTCTTATATTCGGATAAATTTAAGCAAAAAATGAACAATTTTCTAAAATACGTTATTGAAAACTCGTCAC
CCTTCTCAGTGTATGTCAACATTCAATATGTATGACTTTTATTGTGGTATAGCTTAGTGCCAATTTAAGGTATATTGTGTTCCATGGGTC
TTTAGAGCATTCTTTGTACACTTTTTCTAATCAGCACTGTCTTAAGACAACATAACACTGTTAGTAAGGCAATTTATTGGACACAATGGC
ATCGATGATCTTAAAAATATATATATTCTGTACTTAATCCCTTTATTATTTAAAGCCGGGCTTGTAATTTTTCTTTTTAAAATTTAACAT
TATGCAGCCCTGCTCAGTAGAGACTCACTCAGCATTATGACATCATAAATTTTTAAATGCCATATTTTATTCAAGGTGATACGAATAATA
ATAGACATACACTGGAACAGCAGTTGTTGAAATACCCAGATTTTTCACCTTGGTTACTCTGACCTTGGGTCAGAACCTAACTTTACAGTG
CTTCAGTTTTCCCACCTTTTAAGGAGGATAATTACTGATTTCCACGTTAATTTAAAAGAACATTATGAGGATTAGGCGAACACTTTGTAA
TACTTTGCCCAAGAAAAAGAAAAATGTTGTTACTGAAATTATAAGGTATTTTATTGTCTTTAGAACCTTGTAATTGAACAGGGAGATTAT
TTTTGAAGTTTAAAAATTACTAGATAGAATTTGGAAACATGTTGTGGAATAAATGATTCTAAAAAGCATGTGAAAGAGACACACAATGAG
GAAATAGGGAGTTTCTCAAAATCTAAACTTGTACAGGTATCTAAACTTGCCTCAAGTAACTCTCAGATGTCTTATTTAAAATCATTTAGT
GAAAAATGACATTTAAAGCTAAAAAATAATTTAGTTGTACTAATTATGGTACCATAAAGTGCTTTGACATAAATTTGAACCTAGAATTGG
CAGTTCTAATAAAAGTTTTTCCACTTTGTTAAAGGTTATGTCAATCTTGAGTGCTTGTGGAATTCTTCACCACCAATACATATTTTATTA
CTATCTCTTTTAATAATGCATAGGAATTCTTTTTTAGACTAGTTTTTGGGTTTGCTTTGTCTATAACAAAAAATAAATACAACAACTTAA
TAATCACATTTGAAAACAAATTTAACAAGTATAATGTGAGTTTTTCTTTTTTCCTAACTTCCTCAGGACCTAGGTCACCTTTATTAAAAG
GAAGAATTCACTCTTTTTTCCTTGGCAGTTTAATCATTCAGGAATCCCTCTCTTAAAGGAAATTGTTATTTTATTCATGTAACCTTTTTT

>In-frame_ENST00000368068_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(amino acids)=812AA_start in transcript=180_stop in transcript=2618
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKAMFSLCMVES
GADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLV
KHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETAT
ALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFL
FVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSC
HAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTR
CNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAPYFTCPNLQTLQVPHHRIG

--------------------------------------------------------------
>In-frame_ENST00000368060_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(transcript)=4091nt_BP=960nt
GTTCCTGCTGTTGGCTGGGCTCGGGAGGGAACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGA
GGTCTCCGCCCCTCTGCCCCTATATTCCCAGAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAG
ATGGAGACGCAACTGCAGAGCATTTTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCT
GAAGATGAGAAAACAAAACTAATTAGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATC
CAGTGGATTGTTAAGTTTATTCATGGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGT
CTCCTTCCACCCAGGCTGGTTTGTGAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAA
CTGGTTCGGAAAATAATTGGGGGAGTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAAT
ACAGTGAGCTCTGCTGTTGTACAGCAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCC
TATTTTGCAGTCACTGAGATCAGGAAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGAT
ACCTTCAGGCCCACAGCAAGGATAAACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCA
TGGAAACTGGATCCTGCTACTCTTCGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGCAATGTTCAGTCTTTGTATGGTGGAAAGT
GGAGCTGATGAGGTTAATTTGCACGGTGTGACCAGCCTTGGCTTAAAGCAGGCTCTGGAGTTTGCATACACAGGACAGATTTTGCTGGAG
CCAGGTGTGATCCAGGATGTGCTAGCAGCGGGCAGTCACCTACAGCTGTTGGAGCTTCTCAATTTATGCTCCCACTATCTCATCCAGGAA
TTAAATAGCTTTAATTACTTGGATCTGTACAGACTTGCTGACCTCTTTAACCTCACTTTGTTGGAGAAGGCAGTGATCGATTTCTTAGTG
AAACATCTCTCTGAACTCCTGAAGAGCCGCCCAGAAGAAGTTCTAACGCTTCCCTATTGCCTGCTTCAGGAGGTGCTGAAGAGCGACCGC
CTGACCTCCCTGAGTGAAGAGCAGATCTGGCAGCTAGCTGTGAGGTGGTTGGAACACAACTGCCACTACCAGTACATGGACGAGCTCCTG
CAATACATCCGCTTTGGCCTAATGGATGTGGATACTCTCCATACAGTTGCCCTGTCCCACCCCCTTGTCCAAGCAAGTGAGACTGCAACA
GCCCTTGTCAACGAGGCCCTGGAATACCACCAGAGCATCTATGCACAGCCTGTCTGGCAGACTCGCAGGACCAAACCACGATTCCAGTCA
GACACTCTGTATATCATTGGTGGGAAAAAGCGCGAGGTCTGCAAGGTCAAGGAACTTCGGTACTTCAATCCTGTTGATCAGGAGAATGCT
CTCATAGCTGCCATTGCCAACTGGAGTGAGCTGGCTCCCATGCCTGTGGGAAGGAGCCACCATTGTGTGGCAGTCATGGGGGACTTCCTG
TTTGTGGCAGGAGGGGAAGTTGAGCATGCCAGTGGCCGGACGTGTGCTGTGAGGACTGCCTGTCGCTATGACCCCCGCAGTAATTCCTGG
GCAGAGATAGCACCCATGAAAAACTGCCGGGAGCATTTTGTGCTGGGTGCCATGGAGGAATACCTCTATGCAGTTGGGGGCAGAAATGAA
CTGCGCCAGGTTCTGCCTACAGTTGAGCGATATTGCCCCAAGAAGAACAAATGGACTTTTGTTCAGTCCTTTGACAGATCCCTTTCATGC
CATGCTGGATATGTGGCTGATGGTCTTCTTTGGATATCAGGTGGAGTAACTAATACGGCACAATATCAGAACAGGCTAATGGTGTATGAA
CCTAACCAGAATAAGTGGATAAGCCGTAGCCCCATGCTGCAGAGAAGGGTCTACCATTCCATGGCTGCTGTACAAAGGAAGCTTTATGTT
CTTGGAGGCAATGACCTAGACTACAATAATGACCGGATCCTTGTGCGCCATATAGATTCTTACAACATAGACACTGACCAGTGGACACGT
TGTAATTTCAACCTGCTGACTGGCCAAAATGAATCTGGAGTTGCTGTCCATAATGGGAGAATATATTTAGTTGGTGGATATTCAATTTGG
ACAAATGAGCCTCTGGCTTGTATCCAGGTACTGGATGTAAGCAGAGAAGGCAAAGAAGAAGTATTCTATGGGCCTACACTCCCTTTTGCT
TCCAATGGAATAGCAGCATGCTTCCTTCCAGCTCCATATTTTACATGCCCTAACCTTCAAACTCTTCAAGTGCCTCATCACAGGATTGGC
ACCATCTGAAAAGCCAAGCCATCATGAACAGGAGGAAAACATAGCTCTGACTGTTGGATACTGGGCATGAAAAGACTCAGTGCTCCATGC
TTCCTTGTCTTGCTTTATAGGTCTTATATTCGGATAAATTTAAGCAAAAAATGAACAATTTTCTAAAATACGTTATTGAAAACTCGTCAC
CCTTCTCAGTGTATGTCAACATTCAATATGTATGACTTTTATTGTGGTATAGCTTAGTGCCAATTTAAGGTATATTGTGTTCCATGGGTC
TTTAGAGCATTCTTTGTACACTTTTTCTAATCAGCACTGTCTTAAGACAACATAACACTGTTAGTAAGGCAATTTATTGGACACAATGGC
ATCGATGATCTTAAAAATATATATATTCTGTACTTAATCCCTTTATTATTTAAAGCCGGGCTTGTAATTTTTCTTTTTAAAATTTAACAT
TATGCAGCCCTGCTCAGTAGAGACTCACTCAGCATTATGACATCATAAATTTTTAAATGCCATATTTTATTCAAGGTGATACGAATAATA
ATAGACATACACTGGAACAGCAGTTGTTGAAATACCCAGATTTTTCACCTTGGTTACTCTGACCTTGGGTCAGAACCTAACTTTACAGTG
CTTCAGTTTTCCCACCTTTTAAGGAGGATAATTACTGATTTCCACGTTAATTTAAAAGAACATTATGAGGATTAGGCGAACACTTTGTAA
TACTTTGCCCAAGAAAAAGAAAAATGTTGTTACTGAAATTATAAGGTATTTTATTGTCTTTAGAACCTTGTAATTGAACAGGGAGATTAT
TTTTGAAGTTTAAAAATTACTAGATAGAATTTGGAAACATGTTGTGGAATAAATGATTCTAAAAAGCATGTGAAAGAGACACACAATGAG
GAAATAGGGAGTTTCTCAAAATCTAAACTTGTACAGGTATCTAAACTTGCCTCAAGTAACTCTCAGATGTCTTATTTAAAATCATTTAGT
GAAAAATGACATTTAAAGCTAAAAAATAATTTAGTTGTACTAATTATGGTACCATAAAGTGCTTTGACATAAATTTGAACCTAGAATTGG
CAGTTCTAATAAAAGTTTTTCCACTTTGTTAAAGGTTATGTCAATCTTGAGTGCTTGTGGAATTCTTCACCACCAATACATATTTTATTA
CTATCTCTTTTAATAATGCATAGGAATTCTTTTTTAGACTAGTTTTTGGGTTTGCTTTGTCTATAACAAAAAATAAATACAACAACTTAA
TAATCACATTTGAAAACAAATTTAACAAGTATAATGTGAGTTTTTCTTTTTTCCTAACTTCCTCAGGACCTAGGTCACCTTTATTAAAAG
GAAGAATTCACTCTTTTTTCCTTGGCAGTTTAATCATTCAGGAATCCCTCTCTTAAAGGAAATTGTTATTTTATTCATGTAACCTTTTTT

>In-frame_ENST00000368060_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(amino acids)=812AA_start in transcript=180_stop in transcript=2618
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKAMFSLCMVES
GADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLV
KHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETAT
ALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFL
FVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSC
HAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTR
CNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAPYFTCPNLQTLQVPHHRIG

--------------------------------------------------------------
>In-frame_ENST00000368058_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(transcript)=3928nt_BP=797nt
CGGGGGTGATAGTACAGATGGAGACGCAACTGCAGAGCATTTTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCA
TGTTTATGGATACTCCTGAAGATGAGAAAACAAAACTAATTAGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGT
CTCATGAACAGTGTATCCAGTGGATTGTTAAGTTTATTCATGGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAA
TGGCAGTTGAGACTGGTCTCCTTCCACCCAGGCTGGTTTGTGAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTT
GGGCCTTAACATTTAAACTGGTTCGGAAAATAATTGGGGGAGTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGA
TTTTGACAATTCCTAATACAGTGAGCTCTGCTGTTGTACAGCAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATG
CCTGCTTATTACCAGCCTATTTTGCAGTCACTGAGATCAGGAAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAG
TATCAGACTTTGTGGATACCTTCAGGCCCACAGCAAGGATAAACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGG
GTGCCATTTGTAATTCATGGAAACTGGATCCTGCTACTCTTCGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGCAATGTTCAGTC
TTTGTATGGTGGAAAGTGGAGCTGATGAGGTTAATTTGCACGGTGTGACCAGCCTTGGCTTAAAGCAGGCTCTGGAGTTTGCATACACAG
GACAGATTTTGCTGGAGCCAGGTGTGATCCAGGATGTGCTAGCAGCGGGCAGTCACCTACAGCTGTTGGAGCTTCTCAATTTATGCTCCC
ACTATCTCATCCAGGAATTAAATAGCTTTAATTACTTGGATCTGTACAGACTTGCTGACCTCTTTAACCTCACTTTGTTGGAGAAGGCAG
TGATCGATTTCTTAGTGAAACATCTCTCTGAACTCCTGAAGAGCCGCCCAGAAGAAGTTCTAACGCTTCCCTATTGCCTGCTTCAGGAGG
TGCTGAAGAGCGACCGCCTGACCTCCCTGAGTGAAGAGCAGATCTGGCAGCTAGCTGTGAGGTGGTTGGAACACAACTGCCACTACCAGT
ACATGGACGAGCTCCTGCAATACATCCGCTTTGGCCTAATGGATGTGGATACTCTCCATACAGTTGCCCTGTCCCACCCCCTTGTCCAAG
CAAGTGAGACTGCAACAGCCCTTGTCAACGAGGCCCTGGAATACCACCAGAGCATCTATGCACAGCCTGTCTGGCAGACTCGCAGGACCA
AACCACGATTCCAGTCAGACACTCTGTATATCATTGGTGGGAAAAAGCGCGAGGTCTGCAAGGTCAAGGAACTTCGGTACTTCAATCCTG
TTGATCAGGAGAATGCTCTCATAGCTGCCATTGCCAACTGGAGTGAGCTGGCTCCCATGCCTGTGGGAAGGAGCCACCATTGTGTGGCAG
TCATGGGGGACTTCCTGTTTGTGGCAGGAGGGGAAGTTGAGCATGCCAGTGGCCGGACGTGTGCTGTGAGGACTGCCTGTCGCTATGACC
CCCGCAGTAATTCCTGGGCAGAGATAGCACCCATGAAAAACTGCCGGGAGCATTTTGTGCTGGGTGCCATGGAGGAATACCTCTATGCAG
TTGGGGGCAGAAATGAACTGCGCCAGGTTCTGCCTACAGTTGAGCGATATTGCCCCAAGAAGAACAAATGGACTTTTGTTCAGTCCTTTG
ACAGATCCCTTTCATGCCATGCTGGATATGTGGCTGATGGTCTTCTTTGGATATCAGGTGGAGTAACTAATACGGCACAATATCAGAACA
GGCTAATGGTGTATGAACCTAACCAGAATAAGTGGATAAGCCGTAGCCCCATGCTGCAGAGAAGGGTCTACCATTCCATGGCTGCTGTAC
AAAGGAAGCTTTATGTTCTTGGAGGCAATGACCTAGACTACAATAATGACCGGATCCTTGTGCGCCATATAGATTCTTACAACATAGACA
CTGACCAGTGGACACGTTGTAATTTCAACCTGCTGACTGGCCAAAATGAATCTGGAGTTGCTGTCCATAATGGGAGAATATATTTAGTTG
GTGGATATTCAATTTGGACAAATGAGCCTCTGGCTTGTATCCAGGTACTGGATGTAAGCAGAGAAGGCAAAGAAGAAGTATTCTATGGGC
CTACACTCCCTTTTGCTTCCAATGGAATAGCAGCATGCTTCCTTCCAGCTCCATATTTTACATGCCCTAACCTTCAAACTCTTCAAGTGC
CTCATCACAGGATTGGCACCATCTGAAAAGCCAAGCCATCATGAACAGGAGGAAAACATAGCTCTGACTGTTGGATACTGGGCATGAAAA
GACTCAGTGCTCCATGCTTCCTTGTCTTGCTTTATAGGTCTTATATTCGGATAAATTTAAGCAAAAAATGAACAATTTTCTAAAATACGT
TATTGAAAACTCGTCACCCTTCTCAGTGTATGTCAACATTCAATATGTATGACTTTTATTGTGGTATAGCTTAGTGCCAATTTAAGGTAT
ATTGTGTTCCATGGGTCTTTAGAGCATTCTTTGTACACTTTTTCTAATCAGCACTGTCTTAAGACAACATAACACTGTTAGTAAGGCAAT
TTATTGGACACAATGGCATCGATGATCTTAAAAATATATATATTCTGTACTTAATCCCTTTATTATTTAAAGCCGGGCTTGTAATTTTTC
TTTTTAAAATTTAACATTATGCAGCCCTGCTCAGTAGAGACTCACTCAGCATTATGACATCATAAATTTTTAAATGCCATATTTTATTCA
AGGTGATACGAATAATAATAGACATACACTGGAACAGCAGTTGTTGAAATACCCAGATTTTTCACCTTGGTTACTCTGACCTTGGGTCAG
AACCTAACTTTACAGTGCTTCAGTTTTCCCACCTTTTAAGGAGGATAATTACTGATTTCCACGTTAATTTAAAAGAACATTATGAGGATT
AGGCGAACACTTTGTAATACTTTGCCCAAGAAAAAGAAAAATGTTGTTACTGAAATTATAAGGTATTTTATTGTCTTTAGAACCTTGTAA
TTGAACAGGGAGATTATTTTTGAAGTTTAAAAATTACTAGATAGAATTTGGAAACATGTTGTGGAATAAATGATTCTAAAAAGCATGTGA
AAGAGACACACAATGAGGAAATAGGGAGTTTCTCAAAATCTAAACTTGTACAGGTATCTAAACTTGCCTCAAGTAACTCTCAGATGTCTT
ATTTAAAATCATTTAGTGAAAAATGACATTTAAAGCTAAAAAATAATTTAGTTGTACTAATTATGGTACCATAAAGTGCTTTGACATAAA
TTTGAACCTAGAATTGGCAGTTCTAATAAAAGTTTTTCCACTTTGTTAAAGGTTATGTCAATCTTGAGTGCTTGTGGAATTCTTCACCAC
CAATACATATTTTATTACTATCTCTTTTAATAATGCATAGGAATTCTTTTTTAGACTAGTTTTTGGGTTTGCTTTGTCTATAACAAAAAA
TAAATACAACAACTTAATAATCACATTTGAAAACAAATTTAACAAGTATAATGTGAGTTTTTCTTTTTTCCTAACTTCCTCAGGACCTAG
GTCACCTTTATTAAAAGGAAGAATTCACTCTTTTTTCCTTGGCAGTTTAATCATTCAGGAATCCCTCTCTTAAAGGAAATTGTTATTTTA

>In-frame_ENST00000368058_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(amino acids)=812AA_start in transcript=17_stop in transcript=2455
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKAMFSLCMVES
GADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLV
KHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETAT
ALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFL
FVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSC
HAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTR
CNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAPYFTCPNLQTLQVPHHRIG

--------------------------------------------------------------
>In-frame_ENST00000368053_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(transcript)=4061nt_BP=930nt
ACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGAGGTCTCCGCCCCTCTGCCCCTATATTCCCA
GAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAGATGGAGACGCAACTGCAGAGCATTTTCGAA
GAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCTGAAGATGAGAAAACAAAACTAATTAGCTGT
TTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATCCAGTGGATTGTTAAGTTTATTCATGGTCAG
CATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGTCTCCTTCCACCCAGGCTGGTTTGTGAATCC
CTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAACTGGTTCGGAAAATAATTGGGGGAGTGGAT
TACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAATACAGTGAGCTCTGCTGTTGTACAGCAGCTT
CTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCCTATTTTGCAGTCACTGAGATCAGGAAACTG
TATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGATACCTTCAGGCCCACAGCAAGGATAAACTCC
ATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCATGGAAACTGGATCCTGCTACTCTTCGTTTT
CCTTTGAAAGGCCTTTTGCCATATGATAAGGCAATGTTCAGTCTTTGTATGGTGGAAAGTGGAGCTGATGAGGTTAATTTGCACGGTGTG
ACCAGCCTTGGCTTAAAGCAGGCTCTGGAGTTTGCATACACAGGACAGATTTTGCTGGAGCCAGGTGTGATCCAGGATGTGCTAGCAGCG
GGCAGTCACCTACAGCTGTTGGAGCTTCTCAATTTATGCTCCCACTATCTCATCCAGGAATTAAATAGCTTTAATTACTTGGATCTGTAC
AGACTTGCTGACCTCTTTAACCTCACTTTGTTGGAGAAGGCAGTGATCGATTTCTTAGTGAAACATCTCTCTGAACTCCTGAAGAGCCGC
CCAGAAGAAGTTCTAACGCTTCCCTATTGCCTGCTTCAGGAGGTGCTGAAGAGCGACCGCCTGACCTCCCTGAGTGAAGAGCAGATCTGG
CAGCTAGCTGTGAGGTGGTTGGAACACAACTGCCACTACCAGTACATGGACGAGCTCCTGCAATACATCCGCTTTGGCCTAATGGATGTG
GATACTCTCCATACAGTTGCCCTGTCCCACCCCCTTGTCCAAGCAAGTGAGACTGCAACAGCCCTTGTCAACGAGGCCCTGGAATACCAC
CAGAGCATCTATGCACAGCCTGTCTGGCAGACTCGCAGGACCAAACCACGATTCCAGTCAGACACTCTGTATATCATTGGTGGGAAAAAG
CGCGAGGTCTGCAAGGTCAAGGAACTTCGGTACTTCAATCCTGTTGATCAGGAGAATGCTCTCATAGCTGCCATTGCCAACTGGAGTGAG
CTGGCTCCCATGCCTGTGGGAAGGAGCCACCATTGTGTGGCAGTCATGGGGGACTTCCTGTTTGTGGCAGGAGGGGAAGTTGAGCATGCC
AGTGGCCGGACGTGTGCTGTGAGGACTGCCTGTCGCTATGACCCCCGCAGTAATTCCTGGGCAGAGATAGCACCCATGAAAAACTGCCGG
GAGCATTTTGTGCTGGGTGCCATGGAGGAATACCTCTATGCAGTTGGGGGCAGAAATGAACTGCGCCAGGTTCTGCCTACAGTTGAGCGA
TATTGCCCCAAGAAGAACAAATGGACTTTTGTTCAGTCCTTTGACAGATCCCTTTCATGCCATGCTGGATATGTGGCTGATGGTCTTCTT
TGGATATCAGGTGGAGTAACTAATACGGCACAATATCAGAACAGGCTAATGGTGTATGAACCTAACCAGAATAAGTGGATAAGCCGTAGC
CCCATGCTGCAGAGAAGGGTCTACCATTCCATGGCTGCTGTACAAAGGAAGCTTTATGTTCTTGGAGGCAATGACCTAGACTACAATAAT
GACCGGATCCTTGTGCGCCATATAGATTCTTACAACATAGACACTGACCAGTGGACACGTTGTAATTTCAACCTGCTGACTGGCCAAAAT
GAATCTGGAGTTGCTGTCCATAATGGGAGAATATATTTAGTTGGTGGATATTCAATTTGGACAAATGAGCCTCTGGCTTGTATCCAGGTA
CTGGATGTAAGCAGAGAAGGCAAAGAAGAAGTATTCTATGGGCCTACACTCCCTTTTGCTTCCAATGGAATAGCAGCATGCTTCCTTCCA
GCTCCATATTTTACATGCCCTAACCTTCAAACTCTTCAAGTGCCTCATCACAGGATTGGCACCATCTGAAAAGCCAAGCCATCATGAACA
GGAGGAAAACATAGCTCTGACTGTTGGATACTGGGCATGAAAAGACTCAGTGCTCCATGCTTCCTTGTCTTGCTTTATAGGTCTTATATT
CGGATAAATTTAAGCAAAAAATGAACAATTTTCTAAAATACGTTATTGAAAACTCGTCACCCTTCTCAGTGTATGTCAACATTCAATATG
TATGACTTTTATTGTGGTATAGCTTAGTGCCAATTTAAGGTATATTGTGTTCCATGGGTCTTTAGAGCATTCTTTGTACACTTTTTCTAA
TCAGCACTGTCTTAAGACAACATAACACTGTTAGTAAGGCAATTTATTGGACACAATGGCATCGATGATCTTAAAAATATATATATTCTG
TACTTAATCCCTTTATTATTTAAAGCCGGGCTTGTAATTTTTCTTTTTAAAATTTAACATTATGCAGCCCTGCTCAGTAGAGACTCACTC
AGCATTATGACATCATAAATTTTTAAATGCCATATTTTATTCAAGGTGATACGAATAATAATAGACATACACTGGAACAGCAGTTGTTGA
AATACCCAGATTTTTCACCTTGGTTACTCTGACCTTGGGTCAGAACCTAACTTTACAGTGCTTCAGTTTTCCCACCTTTTAAGGAGGATA
ATTACTGATTTCCACGTTAATTTAAAAGAACATTATGAGGATTAGGCGAACACTTTGTAATACTTTGCCCAAGAAAAAGAAAAATGTTGT
TACTGAAATTATAAGGTATTTTATTGTCTTTAGAACCTTGTAATTGAACAGGGAGATTATTTTTGAAGTTTAAAAATTACTAGATAGAAT
TTGGAAACATGTTGTGGAATAAATGATTCTAAAAAGCATGTGAAAGAGACACACAATGAGGAAATAGGGAGTTTCTCAAAATCTAAACTT
GTACAGGTATCTAAACTTGCCTCAAGTAACTCTCAGATGTCTTATTTAAAATCATTTAGTGAAAAATGACATTTAAAGCTAAAAAATAAT
TTAGTTGTACTAATTATGGTACCATAAAGTGCTTTGACATAAATTTGAACCTAGAATTGGCAGTTCTAATAAAAGTTTTTCCACTTTGTT
AAAGGTTATGTCAATCTTGAGTGCTTGTGGAATTCTTCACCACCAATACATATTTTATTACTATCTCTTTTAATAATGCATAGGAATTCT
TTTTTAGACTAGTTTTTGGGTTTGCTTTGTCTATAACAAAAAATAAATACAACAACTTAATAATCACATTTGAAAACAAATTTAACAAGT
ATAATGTGAGTTTTTCTTTTTTCCTAACTTCCTCAGGACCTAGGTCACCTTTATTAAAAGGAAGAATTCACTCTTTTTTCCTTGGCAGTT
TAATCATTCAGGAATCCCTCTCTTAAAGGAAATTGTTATTTTATTCATGTAACCTTTTTTTGTAATCAAAAGTGAATAAAAACGATCTTT

>In-frame_ENST00000368053_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(amino acids)=812AA_start in transcript=150_stop in transcript=2588
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKAMFSLCMVES
GADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLV
KHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETAT
ALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFL
FVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSC
HAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTR
CNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAPYFTCPNLQTLQVPHHRIG

--------------------------------------------------------------
>In-frame_ENST00000540546_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(transcript)=4085nt_BP=954nt
GCTGTTGGCTGGGCTCGGGAGGGAACGCTCCAGGTAAAGCGCTGGGGGAGGAAGCGACGCCGAGGAGCTACGGTTTCCTCCAGAGGTCTC
CGCCCCTCTGCCCCTATATTCCCAGAGCTCGAGTCTGATCCGGGCCTTGCCGGGCACCCTGGAAAGGCGGGGGTGATAGTACAGATGGAG
ACGCAACTGCAGAGCATTTTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCTGGCATGTTTATGGATACTCCTGAAGAT
GAGAAAACAAAACTAATTAGCTGTTTGGGGGCCTTCAGACAGTTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATCCAGTGG
ATTGTTAAGTTTATTCATGGTCAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGTCTCCTT
CCACCCAGGCTGGTTTGTGAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGGGCCTTAACATTTAAACTGGTT
CGGAAAATAATTGGGGGAGTGGATTACAAGGGTGTTCGAGATCTCTTAAAAGTGATTTTGGAGAAGATTTTGACAATTCCTAATACAGTG
AGCTCTGCTGTTGTACAGCAGCTTCTGGCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCCTATTTT
GCAGTCACTGAGATCAGGAAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGACTTTGTGGATACCTTC
AGGCCCACAGCAAGGATAAACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTTGTAAATAATTCGGGTGCCATTTGTAATTCATGGAAA
CTGGATCCTGCTACTCTTCGTTTTCCTTTGAAAGGCCTTTTGCCATATGATAAGGCAATGTTCAGTCTTTGTATGGTGGAAAGTGGAGCT
GATGAGGTTAATTTGCACGGTGTGACCAGCCTTGGCTTAAAGCAGGCTCTGGAGTTTGCATACACAGGACAGATTTTGCTGGAGCCAGGT
GTGATCCAGGATGTGCTAGCAGCGGGCAGTCACCTACAGCTGTTGGAGCTTCTCAATTTATGCTCCCACTATCTCATCCAGGAATTAAAT
AGCTTTAATTACTTGGATCTGTACAGACTTGCTGACCTCTTTAACCTCACTTTGTTGGAGAAGGCAGTGATCGATTTCTTAGTGAAACAT
CTCTCTGAACTCCTGAAGAGCCGCCCAGAAGAAGTTCTAACGCTTCCCTATTGCCTGCTTCAGGAGGTGCTGAAGAGCGACCGCCTGACC
TCCCTGAGTGAAGAGCAGATCTGGCAGCTAGCTGTGAGGTGGTTGGAACACAACTGCCACTACCAGTACATGGACGAGCTCCTGCAATAC
ATCCGCTTTGGCCTAATGGATGTGGATACTCTCCATACAGTTGCCCTGTCCCACCCCCTTGTCCAAGCAAGTGAGACTGCAACAGCCCTT
GTCAACGAGGCCCTGGAATACCACCAGAGCATCTATGCACAGCCTGTCTGGCAGACTCGCAGGACCAAACCACGATTCCAGTCAGACACT
CTGTATATCATTGGTGGGAAAAAGCGCGAGGTCTGCAAGGTCAAGGAACTTCGGTACTTCAATCCTGTTGATCAGGAGAATGCTCTCATA
GCTGCCATTGCCAACTGGAGTGAGCTGGCTCCCATGCCTGTGGGAAGGAGCCACCATTGTGTGGCAGTCATGGGGGACTTCCTGTTTGTG
GCAGGAGGGGAAGTTGAGCATGCCAGTGGCCGGACGTGTGCTGTGAGGACTGCCTGTCGCTATGACCCCCGCAGTAATTCCTGGGCAGAG
ATAGCACCCATGAAAAACTGCCGGGAGCATTTTGTGCTGGGTGCCATGGAGGAATACCTCTATGCAGTTGGGGGCAGAAATGAACTGCGC
CAGGTTCTGCCTACAGTTGAGCGATATTGCCCCAAGAAGAACAAATGGACTTTTGTTCAGTCCTTTGACAGATCCCTTTCATGCCATGCT
GGATATGTGGCTGATGGTCTTCTTTGGATATCAGGTGGAGTAACTAATACGGCACAATATCAGAACAGGCTAATGGTGTATGAACCTAAC
CAGAATAAGTGGATAAGCCGTAGCCCCATGCTGCAGAGAAGGGTCTACCATTCCATGGCTGCTGTACAAAGGAAGCTTTATGTTCTTGGA
GGCAATGACCTAGACTACAATAATGACCGGATCCTTGTGCGCCATATAGATTCTTACAACATAGACACTGACCAGTGGACACGTTGTAAT
TTCAACCTGCTGACTGGCCAAAATGAATCTGGAGTTGCTGTCCATAATGGGAGAATATATTTAGTTGGTGGATATTCAATTTGGACAAAT
GAGCCTCTGGCTTGTATCCAGGTACTGGATGTAAGCAGAGAAGGCAAAGAAGAAGTATTCTATGGGCCTACACTCCCTTTTGCTTCCAAT
GGAATAGCAGCATGCTTCCTTCCAGCTCCATATTTTACATGCCCTAACCTTCAAACTCTTCAAGTGCCTCATCACAGGATTGGCACCATC
TGAAAAGCCAAGCCATCATGAACAGGAGGAAAACATAGCTCTGACTGTTGGATACTGGGCATGAAAAGACTCAGTGCTCCATGCTTCCTT
GTCTTGCTTTATAGGTCTTATATTCGGATAAATTTAAGCAAAAAATGAACAATTTTCTAAAATACGTTATTGAAAACTCGTCACCCTTCT
CAGTGTATGTCAACATTCAATATGTATGACTTTTATTGTGGTATAGCTTAGTGCCAATTTAAGGTATATTGTGTTCCATGGGTCTTTAGA
GCATTCTTTGTACACTTTTTCTAATCAGCACTGTCTTAAGACAACATAACACTGTTAGTAAGGCAATTTATTGGACACAATGGCATCGAT
GATCTTAAAAATATATATATTCTGTACTTAATCCCTTTATTATTTAAAGCCGGGCTTGTAATTTTTCTTTTTAAAATTTAACATTATGCA
GCCCTGCTCAGTAGAGACTCACTCAGCATTATGACATCATAAATTTTTAAATGCCATATTTTATTCAAGGTGATACGAATAATAATAGAC
ATACACTGGAACAGCAGTTGTTGAAATACCCAGATTTTTCACCTTGGTTACTCTGACCTTGGGTCAGAACCTAACTTTACAGTGCTTCAG
TTTTCCCACCTTTTAAGGAGGATAATTACTGATTTCCACGTTAATTTAAAAGAACATTATGAGGATTAGGCGAACACTTTGTAATACTTT
GCCCAAGAAAAAGAAAAATGTTGTTACTGAAATTATAAGGTATTTTATTGTCTTTAGAACCTTGTAATTGAACAGGGAGATTATTTTTGA
AGTTTAAAAATTACTAGATAGAATTTGGAAACATGTTGTGGAATAAATGATTCTAAAAAGCATGTGAAAGAGACACACAATGAGGAAATA
GGGAGTTTCTCAAAATCTAAACTTGTACAGGTATCTAAACTTGCCTCAAGTAACTCTCAGATGTCTTATTTAAAATCATTTAGTGAAAAA
TGACATTTAAAGCTAAAAAATAATTTAGTTGTACTAATTATGGTACCATAAAGTGCTTTGACATAAATTTGAACCTAGAATTGGCAGTTC
TAATAAAAGTTTTTCCACTTTGTTAAAGGTTATGTCAATCTTGAGTGCTTGTGGAATTCTTCACCACCAATACATATTTTATTACTATCT
CTTTTAATAATGCATAGGAATTCTTTTTTAGACTAGTTTTTGGGTTTGCTTTGTCTATAACAAAAAATAAATACAACAACTTAATAATCA
CATTTGAAAACAAATTTAACAAGTATAATGTGAGTTTTTCTTTTTTCCTAACTTCCTCAGGACCTAGGTCACCTTTATTAAAAGGAAGAA
TTCACTCTTTTTTCCTTGGCAGTTTAATCATTCAGGAATCCCTCTCTTAAAGGAAATTGTTATTTTATTCATGTAACCTTTTTTTGTAAT

>In-frame_ENST00000540546_ENST00000369261_TCGA-AR-A0TW-01A_MED23_chr6_131939547_-_KLHL32_chr6_97489368_length(amino acids)=812AA_start in transcript=174_stop in transcript=2612
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETG
LLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPA
YFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKAMFSLCMVES
GADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLV
KHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETAT
ALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFL
FVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSC
HAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTR
CNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAPYFTCPNLQTLQVPHHRIG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MED23-KLHL32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED23-KLHL32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED23-KLHL32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMED23C3280265MENTAL RETARDATION, AUTOSOMAL RECESSIVE 182CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneMED23C3714756Intellectual Disability1GENOMICS_ENGLAND