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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MED23-MED23 (FusionGDB2 ID:52388)

Fusion Gene Summary for MED23-MED23

Fusion gene summary

Fusion gene information	Fusion gene name: MED23-MED23
	Fusion gene ID: 52388
		Hgene	Tgene
	Gene symbol	MED23	MED23
	Gene ID	9439	9439
	Gene name	mediator complex subunit 23	mediator complex subunit 23
	Synonyms	ARC130\|CRSP130\|CRSP133\|CRSP3\|DRIP130\|MRT18\|SUR-2\|SUR2	ARC130\|CRSP130\|CRSP133\|CRSP3\|DRIP130\|MRT18\|SUR-2\|SUR2
	Cytomap	6q23.2	6q23.2
	Type of gene	protein-coding	protein-coding
	Description	mediator of RNA polymerase II transcription subunit 23130 kDa transcriptional co-activator133 kDa transcriptional co-activatoractivator-recruited cofactor 130 kDa componentcofactor required for Sp1 transcriptional activation subunit 3mental retardati	mediator of RNA polymerase II transcription subunit 23130 kDa transcriptional co-activator133 kDa transcriptional co-activatoractivator-recruited cofactor 130 kDa componentcofactor required for Sp1 transcriptional activation subunit 3mental retardati
	Modification date	20200313	20200313
	UniProtAcc	Q9ULK4	Q9ULK4
	Ensembl transtripts involved in fusion gene	ENST00000354577, ENST00000403834, ENST00000368068, ENST00000479213, ENST00000368060, ENST00000368058, ENST00000545957, ENST00000368053, ENST00000540546, ENST00000539158,	ENST00000354577, ENST00000403834, ENST00000368068, ENST00000479213, ENST00000368060, ENST00000368058, ENST00000545957, ENST00000368053, ENST00000540546, ENST00000539158,
Fusion gene scores	* DoF score	6 X 8 X 4=192	4 X 6 X 3=72
	# samples	9	6
	** MAII score	log2(9/192*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MED23 [Title/Abstract] AND MED23 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MED23(131932398)-MED23(131932481), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MED23	GO:0006355	regulation of transcription, DNA-templated	9989412
Tgene	MED23	GO:0006355	regulation of transcription, DNA-templated	9989412

Fusion gene breakpoints across MED23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MED23 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AA648178	MED23	chr6	131932398	-	MED23	chr6	131932481	+
ChiTaRS5.0	N/A	AA648640	MED23	chr6	131932398	-	MED23	chr6	131932481	+
ChiTaRS5.0	N/A	AA721515	MED23	chr6	131932398	-	MED23	chr6	131932481	+
ChiTaRS5.0	N/A	AW363299	MED23	chr6	131930370	+	MED23	chr6	131931678	-
ChiTaRS5.0	N/A	BQ223279	MED23	chr6	131910657	+	MED23	chr6	131908986	-

Top

Fusion Gene ORF analysis for MED23-MED23

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000354577	ENST00000354577	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000354577	ENST00000403834	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000354577	ENST00000368068	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000354577	ENST00000479213	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000354577	ENST00000368060	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000354577	ENST00000368058	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000354577	ENST00000545957	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000354577	ENST00000368053	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000354577	ENST00000540546	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000354577	ENST00000539158	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000403834	ENST00000354577	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000403834	ENST00000403834	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000403834	ENST00000368068	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000403834	ENST00000479213	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000403834	ENST00000368060	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000403834	ENST00000368058	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000403834	ENST00000545957	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000403834	ENST00000368053	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000403834	ENST00000540546	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000403834	ENST00000539158	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368068	ENST00000354577	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368068	ENST00000403834	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368068	ENST00000368068	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368068	ENST00000479213	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368068	ENST00000368060	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368068	ENST00000368058	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368068	ENST00000545957	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368068	ENST00000368053	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368068	ENST00000540546	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368068	ENST00000539158	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000479213	ENST00000354577	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000479213	ENST00000403834	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000479213	ENST00000368068	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000479213	ENST00000479213	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000479213	ENST00000368060	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000479213	ENST00000368058	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000479213	ENST00000545957	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000479213	ENST00000368053	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000479213	ENST00000540546	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000479213	ENST00000539158	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368060	ENST00000354577	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368060	ENST00000403834	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368060	ENST00000368068	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368060	ENST00000479213	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368060	ENST00000368060	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368060	ENST00000368058	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368060	ENST00000545957	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368060	ENST00000368053	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368060	ENST00000540546	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368060	ENST00000539158	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368058	ENST00000354577	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368058	ENST00000403834	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368058	ENST00000368068	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368058	ENST00000479213	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368058	ENST00000368060	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368058	ENST00000368058	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368058	ENST00000545957	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368058	ENST00000368053	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368058	ENST00000540546	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368058	ENST00000539158	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000545957	ENST00000354577	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000545957	ENST00000403834	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000545957	ENST00000368068	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000545957	ENST00000479213	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000545957	ENST00000368060	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000545957	ENST00000368058	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000545957	ENST00000545957	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000545957	ENST00000368053	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000545957	ENST00000540546	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000545957	ENST00000539158	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368053	ENST00000354577	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368053	ENST00000403834	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368053	ENST00000368068	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368053	ENST00000479213	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368053	ENST00000368060	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368053	ENST00000368058	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368053	ENST00000545957	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368053	ENST00000368053	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368053	ENST00000540546	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000368053	ENST00000539158	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000540546	ENST00000354577	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000540546	ENST00000403834	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000540546	ENST00000368068	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000540546	ENST00000479213	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000540546	ENST00000368060	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000540546	ENST00000368058	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000540546	ENST00000545957	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000540546	ENST00000368053	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000540546	ENST00000540546	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000540546	ENST00000539158	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000539158	ENST00000354577	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000539158	ENST00000403834	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000539158	ENST00000368068	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000539158	ENST00000479213	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000539158	ENST00000368060	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000539158	ENST00000368058	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000539158	ENST00000545957	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000539158	ENST00000368053	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000539158	ENST00000540546	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000539158	ENST00000539158	MED23	chr6	131932398	-	MED23	chr6	131932481	+
intron-intron	ENST00000354577	ENST00000354577	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000354577	ENST00000403834	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000354577	ENST00000368068	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000354577	ENST00000479213	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000354577	ENST00000368060	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000354577	ENST00000368058	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000354577	ENST00000545957	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000354577	ENST00000368053	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000354577	ENST00000540546	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000354577	ENST00000539158	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000403834	ENST00000354577	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000403834	ENST00000403834	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000403834	ENST00000368068	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000403834	ENST00000479213	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000403834	ENST00000368060	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000403834	ENST00000368058	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000403834	ENST00000545957	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000403834	ENST00000368053	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000403834	ENST00000540546	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000403834	ENST00000539158	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368068	ENST00000354577	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368068	ENST00000403834	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368068	ENST00000368068	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368068	ENST00000479213	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368068	ENST00000368060	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368068	ENST00000368058	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368068	ENST00000545957	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368068	ENST00000368053	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368068	ENST00000540546	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368068	ENST00000539158	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000479213	ENST00000354577	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000479213	ENST00000403834	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000479213	ENST00000368068	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000479213	ENST00000479213	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000479213	ENST00000368060	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000479213	ENST00000368058	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000479213	ENST00000545957	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000479213	ENST00000368053	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000479213	ENST00000540546	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000479213	ENST00000539158	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368060	ENST00000354577	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368060	ENST00000403834	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368060	ENST00000368068	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368060	ENST00000479213	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368060	ENST00000368060	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368060	ENST00000368058	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368060	ENST00000545957	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368060	ENST00000368053	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368060	ENST00000540546	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368060	ENST00000539158	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368058	ENST00000354577	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368058	ENST00000403834	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368058	ENST00000368068	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368058	ENST00000479213	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368058	ENST00000368060	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368058	ENST00000368058	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368058	ENST00000545957	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368058	ENST00000368053	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368058	ENST00000540546	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368058	ENST00000539158	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000545957	ENST00000354577	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000545957	ENST00000403834	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000545957	ENST00000368068	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000545957	ENST00000479213	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000545957	ENST00000368060	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000545957	ENST00000368058	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000545957	ENST00000545957	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000545957	ENST00000368053	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000545957	ENST00000540546	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000545957	ENST00000539158	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368053	ENST00000354577	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368053	ENST00000403834	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368053	ENST00000368068	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368053	ENST00000479213	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368053	ENST00000368060	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368053	ENST00000368058	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368053	ENST00000545957	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368053	ENST00000368053	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368053	ENST00000540546	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000368053	ENST00000539158	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000540546	ENST00000354577	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000540546	ENST00000403834	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000540546	ENST00000368068	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000540546	ENST00000479213	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000540546	ENST00000368060	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000540546	ENST00000368058	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000540546	ENST00000545957	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000540546	ENST00000368053	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000540546	ENST00000540546	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000540546	ENST00000539158	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000539158	ENST00000354577	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000539158	ENST00000403834	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000539158	ENST00000368068	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000539158	ENST00000479213	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000539158	ENST00000368060	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000539158	ENST00000368058	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000539158	ENST00000545957	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000539158	ENST00000368053	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000539158	ENST00000540546	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-intron	ENST00000539158	ENST00000539158	MED23	chr6	131930370	+	MED23	chr6	131931678	-
intron-3CDS	ENST00000354577	ENST00000354577	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000354577	ENST00000403834	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000354577	ENST00000368068	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000354577	ENST00000479213	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000354577	ENST00000368060	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000354577	ENST00000368058	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000354577	ENST00000545957	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000354577	ENST00000368053	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000354577	ENST00000540546	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000354577	ENST00000539158	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000403834	ENST00000354577	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000403834	ENST00000403834	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000403834	ENST00000368068	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000403834	ENST00000479213	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000403834	ENST00000368060	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000403834	ENST00000368058	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000403834	ENST00000545957	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000403834	ENST00000368053	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000403834	ENST00000540546	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000403834	ENST00000539158	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368068	ENST00000354577	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368068	ENST00000403834	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368068	ENST00000368068	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368068	ENST00000479213	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368068	ENST00000368060	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368068	ENST00000368058	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368068	ENST00000545957	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368068	ENST00000368053	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368068	ENST00000540546	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368068	ENST00000539158	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000479213	ENST00000354577	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000479213	ENST00000403834	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000479213	ENST00000368068	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000479213	ENST00000479213	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000479213	ENST00000368060	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000479213	ENST00000368058	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000479213	ENST00000545957	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000479213	ENST00000368053	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000479213	ENST00000540546	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000479213	ENST00000539158	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368060	ENST00000354577	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368060	ENST00000403834	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368060	ENST00000368068	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368060	ENST00000479213	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368060	ENST00000368060	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368060	ENST00000368058	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368060	ENST00000545957	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368060	ENST00000368053	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368060	ENST00000540546	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368060	ENST00000539158	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368058	ENST00000354577	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368058	ENST00000403834	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368058	ENST00000368068	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368058	ENST00000479213	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368058	ENST00000368060	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368058	ENST00000368058	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368058	ENST00000545957	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368058	ENST00000368053	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368058	ENST00000540546	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368058	ENST00000539158	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000545957	ENST00000354577	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000545957	ENST00000403834	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000545957	ENST00000368068	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000545957	ENST00000479213	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000545957	ENST00000368060	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000545957	ENST00000368058	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000545957	ENST00000545957	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000545957	ENST00000368053	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000545957	ENST00000540546	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000545957	ENST00000539158	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368053	ENST00000354577	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368053	ENST00000403834	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000368053	ENST00000368068	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368053	ENST00000479213	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368053	ENST00000368060	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368053	ENST00000368058	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000368053	ENST00000545957	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368053	ENST00000368053	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368053	ENST00000540546	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000368053	ENST00000539158	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000540546	ENST00000354577	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000540546	ENST00000403834	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000540546	ENST00000368068	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000540546	ENST00000479213	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000540546	ENST00000368060	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000540546	ENST00000368058	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000540546	ENST00000545957	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000540546	ENST00000368053	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000540546	ENST00000540546	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000540546	ENST00000539158	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000539158	ENST00000354577	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000539158	ENST00000403834	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-3CDS	ENST00000539158	ENST00000368068	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000539158	ENST00000479213	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000539158	ENST00000368060	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000539158	ENST00000368058	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-5UTR	ENST00000539158	ENST00000545957	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000539158	ENST00000368053	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000539158	ENST00000540546	MED23	chr6	131910657	+	MED23	chr6	131908986	-
intron-intron	ENST00000539158	ENST00000539158	MED23	chr6	131910657	+	MED23	chr6	131908986	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MED23-MED23

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED23-MED23

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MED23 Q9ULK4	MED23 Q9ULK4
FUNCTION: Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269\|PubMed:10353252, ECO:0000269\|PubMed:14759369, ECO:0000269\|PubMed:16595664}.	FUNCTION: Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269\|PubMed:10353252, ECO:0000269\|PubMed:14759369, ECO:0000269\|PubMed:16595664}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MED23-MED23

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MED23-MED23

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MED23-MED23

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MED23-MED23

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MED23	C3280265	MENTAL RETARDATION, AUTOSOMAL RECESSIVE 18	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	MED23	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Tgene	MED23	C3280265	MENTAL RETARDATION, AUTOSOMAL RECESSIVE 18	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	MED23	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND