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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MED25-TRPM4 (FusionGDB2 ID:52420)

Fusion Gene Summary for MED25-TRPM4

check button Fusion gene summary
Fusion gene informationFusion gene name: MED25-TRPM4
Fusion gene ID: 52420
HgeneTgene
Gene symbol

MED25

TRPM4

Gene ID

81857

54795

Gene namemediator complex subunit 25transient receptor potential cation channel subfamily M member 4
SynonymsACID1|ARC92|BVSYS|CMT2B2|P78|PTOV2|TCBAP0758EKVP6|LTrpC4|PFHB1B|TRPM4B|hTRPM4
Cytomap

19q13.33

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionmediator of RNA polymerase II transcription subunit 25ARC/mediator transcriptional coactivator subunitactivator interaction domain-containing protein 1activator-recruited cofactor 92 kDa componentmediator of RNA polymerase II transcription, subunit 25transient receptor potential cation channel subfamily M member 4calcium-activated non-selective cation channel 1long transient receptor potential channel 4melastatin-4
Modification date2020032820200320
UniProtAcc

Q71SY5

.
Ensembl transtripts involved in fusion geneENST00000312865, ENST00000538643, 
ENST00000252826, ENST00000427978, 
ENST00000355712, ENST00000601347, 
Fusion gene scores* DoF score10 X 6 X 6=36010 X 9 X 4=360
# samples 1313
** MAII scorelog2(13/360*10)=-1.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/360*10)=-1.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MED25 [Title/Abstract] AND TRPM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMED25(50322553)-TRPM4(49669298), # samples:1
MED25(50321873)-TRPM4(49669298), # samples:1
Anticipated loss of major functional domain due to fusion event.MED25-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MED25-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MED25-TRPM4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMED25

GO:0045944

positive regulation of transcription by RNA polymerase II

17641689

TgeneTRPM4

GO:0002724

regulation of T cell cytokine production

20656926

TgeneTRPM4

GO:0008284

positive regulation of cell proliferation

20625999

TgeneTRPM4

GO:0016925

protein sumoylation

19726882

TgeneTRPM4

GO:0019722

calcium-mediated signaling

27207958

TgeneTRPM4

GO:0051289

protein homotetramerization

29211723|29217581

TgeneTRPM4

GO:0090263

positive regulation of canonical Wnt signaling pathway

20625999

TgeneTRPM4

GO:0098662

inorganic cation transmembrane transport

29211723

TgeneTRPM4

GO:0098719

sodium ion import across plasma membrane

27207958


check buttonFusion gene breakpoints across MED25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRPM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-D1-A1NU-01AMED25chr19

50322553

+TRPM4chr19

49669298

+
ChimerDB4UCECTCGA-D1-A1NU-01AMED25chr19

50321873

+TRPM4chr19

49669298

+


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Fusion Gene ORF analysis for MED25-TRPM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000312865ENST00000252826MED25chr19

50322553

+TRPM4chr19

49669298

+
In-frameENST00000312865ENST00000427978MED25chr19

50322553

+TRPM4chr19

49669298

+
5CDS-intronENST00000312865ENST00000355712MED25chr19

50322553

+TRPM4chr19

49669298

+
5CDS-intronENST00000312865ENST00000601347MED25chr19

50322553

+TRPM4chr19

49669298

+
intron-3CDSENST00000538643ENST00000252826MED25chr19

50322553

+TRPM4chr19

49669298

+
intron-3CDSENST00000538643ENST00000427978MED25chr19

50322553

+TRPM4chr19

49669298

+
intron-intronENST00000538643ENST00000355712MED25chr19

50322553

+TRPM4chr19

49669298

+
intron-intronENST00000538643ENST00000601347MED25chr19

50322553

+TRPM4chr19

49669298

+
Frame-shiftENST00000312865ENST00000252826MED25chr19

50321873

+TRPM4chr19

49669298

+
Frame-shiftENST00000312865ENST00000427978MED25chr19

50321873

+TRPM4chr19

49669298

+
5CDS-intronENST00000312865ENST00000355712MED25chr19

50321873

+TRPM4chr19

49669298

+
5CDS-intronENST00000312865ENST00000601347MED25chr19

50321873

+TRPM4chr19

49669298

+
Frame-shiftENST00000538643ENST00000252826MED25chr19

50321873

+TRPM4chr19

49669298

+
Frame-shiftENST00000538643ENST00000427978MED25chr19

50321873

+TRPM4chr19

49669298

+
5CDS-intronENST00000538643ENST00000355712MED25chr19

50321873

+TRPM4chr19

49669298

+
5CDS-intronENST00000538643ENST00000601347MED25chr19

50321873

+TRPM4chr19

49669298

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000312865MED25chr1950322553+ENST00000252826TRPM4chr1949669298+42493585339101285
ENST00000312865MED25chr1950322553+ENST00000427978TRPM4chr1949669298+36583585334751140

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000312865ENST00000252826MED25chr1950322553+TRPM4chr1949669298+0.0012650590.9987349
ENST00000312865ENST00000427978MED25chr1950322553+TRPM4chr1949669298+0.0011058270.99889416

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Fusion Genomic Features for MED25-TRPM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MED25-TRPM4


check button Go to

FGviewer for the breakpoints of chr19:50322553-chr19:49669298

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED25

Q71SY5

.
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. {ECO:0000269|PubMed:14657022, ECO:0000269|PubMed:14983011, ECO:0000269|PubMed:17641689}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRPM4chr19:50322553chr19:49669298ENST000002528261251134_118730.6666666666666681215.0Coiled coilOntology_term=ECO:0000255
TgeneTRPM4chr19:50322553chr19:49669298ENST000004279781241134_118730.6666666666666681070.0Coiled coilOntology_term=ECO:0000255
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125964_98430.6666666666666681215.0IntramembranePore-forming
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124964_98430.6666666666666681070.0IntramembranePore-forming
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125975_97730.6666666666666681215.0MotifSelectivity filter
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124975_97730.6666666666666681070.0MotifSelectivity filter
TgeneTRPM4chr19:50322553chr19:49669298ENST000002528261251076_117630.6666666666666681215.0RegionNote=Calmodulin-binding
TgeneTRPM4chr19:50322553chr19:49669298ENST000004279781241076_117630.6666666666666681070.0RegionNote=Calmodulin-binding
TgeneTRPM4chr19:50322553chr19:49669298ENST000002528261251041_121430.6666666666666681215.0Topological domainCytoplasmic
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125804_81430.6666666666666681215.0Topological domainExtracellular
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125836_86330.6666666666666681215.0Topological domainCytoplasmic
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125885_88630.6666666666666681215.0Topological domainExtracellular
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125911_93030.6666666666666681215.0Topological domainCytoplasmic
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125952_96330.6666666666666681215.0Topological domainExtracellular
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125985_101930.6666666666666681215.0Topological domainExtracellular
TgeneTRPM4chr19:50322553chr19:49669298ENST000004279781241041_121430.6666666666666681070.0Topological domainCytoplasmic
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124804_81430.6666666666666681070.0Topological domainExtracellular
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124836_86330.6666666666666681070.0Topological domainCytoplasmic
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124885_88630.6666666666666681070.0Topological domainExtracellular
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124911_93030.6666666666666681070.0Topological domainCytoplasmic
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124952_96330.6666666666666681070.0Topological domainExtracellular
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124985_101930.6666666666666681070.0Topological domainExtracellular
TgeneTRPM4chr19:50322553chr19:49669298ENST000002528261251020_104030.6666666666666681215.0TransmembraneHelical
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125783_80330.6666666666666681215.0TransmembraneHelical
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125815_83530.6666666666666681215.0TransmembraneHelical
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125864_88430.6666666666666681215.0TransmembraneHelical
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125887_91030.6666666666666681215.0TransmembraneHelical
TgeneTRPM4chr19:50322553chr19:49669298ENST00000252826125931_95130.6666666666666681215.0TransmembraneHelical
TgeneTRPM4chr19:50322553chr19:49669298ENST000004279781241020_104030.6666666666666681070.0TransmembraneHelical
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124783_80330.6666666666666681070.0TransmembraneHelical
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124815_83530.6666666666666681070.0TransmembraneHelical
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124864_88430.6666666666666681070.0TransmembraneHelical
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124887_91030.6666666666666681070.0TransmembraneHelical
TgeneTRPM4chr19:50322553chr19:49669298ENST00000427978124931_95130.6666666666666681070.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED25chr19:50322553chr19:49669298ENST00000312865+318200_381101.66666666666667748.0Compositional biasNote=Pro-rich
HgeneMED25chr19:50322553chr19:49669298ENST00000312865+318565_735101.66666666666667748.0Compositional biasNote=Pro-rich
HgeneMED25chr19:50322553chr19:49669298ENST00000538643+113200_3810.0535.0Compositional biasNote=Pro-rich
HgeneMED25chr19:50322553chr19:49669298ENST00000538643+113565_7350.0535.0Compositional biasNote=Pro-rich
HgeneMED25chr19:50322553chr19:49669298ENST00000312865+318646_650101.66666666666667748.0MotifNote=LXXLL motif
HgeneMED25chr19:50322553chr19:49669298ENST00000538643+113646_6500.0535.0MotifNote=LXXLL motif
TgeneTRPM4chr19:50322553chr19:49669298ENST000002528261251_78230.6666666666666681215.0Topological domainCytoplasmic
TgeneTRPM4chr19:50322553chr19:49669298ENST000004279781241_78230.6666666666666681070.0Topological domainCytoplasmic


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Fusion Gene Sequence for MED25-TRPM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000312865_ENST00000252826_TCGA-D1-A1NU-01A_MED25_chr19_50322553_+_TRPM4_chr19_49669298_length(transcript)=4249nt_BP=358nt
ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA
GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG
CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA
CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAAG
GGACCTTGTGCCAGTGTGGGCGCCCCCGGACCGCCCACCCCGCAGTGGCCATGGAGGATGCCTTCGGGGCAGCCGTGGTGACCGTGTGGG
ACAGCGATGCACACACCACGGAGAAGCCCACCGATGCCTACGGAGAGCTGGACTTCACGGGGGCCGGCCGCAAGCACAGCAATTTCCTCC
GGCTCTCTGACCGAACGGATCCAGCTGCAGTTTATAGTCTGGTCACACGCACATGGGGCTTCCGTGCCCCGAACCTGGTGGTGTCAGTGC
TGGGGGGATCGGGGGGCCCCGTCCTCCAGACCTGGCTGCAGGACCTGCTGCGTCGTGGGCTGGTGCGGGCTGCCCAGAGCACAGGAGCCT
GGATTGTCACTGGGGGTCTGCACACGGGCATCGGCCGGCATGTTGGTGTGGCTGTACGGGACCATCAGATGGCCAGCACTGGGGGCACCA
AGGTGGTGGCCATGGGTGTGGCCCCCTGGGGTGTGGTCCGGAATAGAGACACCCTCATCAACCCCAAGGGCTCGTTCCCTGCGAGGTACC
GGTGGCGCGGTGACCCGGAGGACGGGGTCCAGTTTCCCCTGGACTACAACTACTCGGCCTTCTTCCTGGTGGACGACGGCACACACGGCT
GCCTGGGGGGCGAGAACCGCTTCCGCTTGCGCCTGGAGTCCTACATCTCACAGCAGAAGACGGGCGTGGGAGGGACTGGAATTGACATCC
CTGTCCTGCTCCTCCTGATTGATGGTGATGAGAAGATGTTGACGCGAATAGAGAACGCCACCCAGGCTCAGCTCCCATGTCTCCTCGTGG
CTGGCTCAGGGGGAGCTGCGGACTGCCTGGCGGAGACCCTGGAAGACACTCTGGCCCCAGGGAGTGGGGGAGCCAGGCAAGGCGAAGCCC
GAGATCGAATCAGGCGTTTCTTTCCCAAAGGGGACCTTGAGGTCCTGCAGGCCCAGGTGGAGAGGATTATGACCCGGAAGGAGCTCCTGA
CAGTCTATTCTTCTGAGGATGGGTCTGAGGAATTCGAGACCATAGTTTTGAAGGCCCTTGTGAAGGCCTGTGGGAGCTCGGAGGCCTCAG
CCTACCTGGATGAGCTGCGTTTGGCTGTGGCTTGGAACCGCGTGGACATTGCCCAGAGTGAACTCTTTCGGGGGGACATCCAATGGCGGT
CCTTCCATCTCGAAGCTTCCCTCATGGACGCCCTGCTGAATGACCGGCCTGAGTTCGTGCGCTTGCTCATTTCCCACGGCCTCAGCCTGG
GCCACTTCCTGACCCCGATGCGCCTGGCCCAACTCTACAGCGCGGCGCCCTCCAACTCGCTCATCCGCAACCTTTTGGACCAGGCGTCCC
ACAGCGCAGGCACCAAAGCCCCAGCCCTAAAAGGGGGAGCTGCGGAGCTCCGGCCCCCTGACGTGGGGCATGTGCTGAGGATGCTGCTGG
GGAAGATGTGCGCGCCGAGGTACCCCTCCGGGGGCGCCTGGGACCCTCACCCAGGCCAGGGCTTCGGGGAGAGCATGTATCTGCTCTCGG
ACAAGGCCACCTCGCCGCTCTCGCTGGATGCTGGCCTCGGGCAGGCCCCCTGGAGCGACCTGCTTCTTTGGGCACTGTTGCTGAACAGGG
CACAGATGGCCATGTACTTCTGGGAGATGGGTTCCAATGCAGTTTCCTCAGCTCTTGGGGCCTGTTTGCTGCTCCGGGTGATGGCACGCC
TGGAGCCTGACGCTGAGGAGGCAGCACGGAGGAAAGACCTGGCGTTCAAGTTTGAGGGGATGGGCGTTGACCTCTTTGGCGAGTGCTATC
GCAGCAGTGAGGTGAGGGCTGCCCGCCTCCTCCTCCGTCGCTGCCCGCTCTGGGGGGATGCCACTTGCCTCCAGCTGGCCATGCAAGCTG
ACGCCCGTGCCTTCTTTGCCCAGGATGGGGTACAGTCTCTGCTGACACAGAAGTGGTGGGGAGATATGGCCAGCACTACACCCATCTGGG
CCCTGGTTCTCGCCTTCTTTTGCCCTCCACTCATCTACACCCGCCTCATCACCTTCAGGAAATCAGAAGAGGAGCCCACACGGGAGGAGC
TAGAGTTTGACATGGATAGTGTCATTAATGGGGAAGGGCCTGTCGGGACGGCGGACCCAGCCGAGAAGACGCCGCTGGGGGTCCCGCGCC
AGTCGGGCCGTCCGGGTTGCTGCGGGGGCCGCTGCGGGGGGCGCCGGTGCCTACGCCGCTGGTTCCACTTCTGGGGCGCGCCGGTGACCA
TCTTCATGGGCAACGTGGTCAGCTACCTGCTGTTCCTGCTGCTTTTCTCGCGGGTGCTGCTCGTGGATTTCCAGCCGGCGCCGCCCGGCT
CCCTGGAGCTGCTGCTCTATTTCTGGGCTTTCACGCTGCTGTGCGAGGAACTGCGCCAGGGCCTGAGCGGAGGCGGGGGCAGCCTCGCCA
GCGGGGGCCCCGGGCCTGGCCATGCCTCACTGAGCCAGCGCCTGCGCCTCTACCTCGCCGACAGCTGGAACCAGTGCGACCTAGTGGCTC
TCACCTGCTTCCTCCTGGGCGTGGGCTGCCGGCTGACCCCGGGTTTGTACCACCTGGGCCGCACTGTCCTCTGCATCGACTTCATGGTTT
TCACGGTGCGGCTGCTTCACATCTTCACGGTCAACAAACAGCTGGGGCCCAAGATCGTCATCGTGAGCAAGATGATGAAGGACGTGTTCT
TCTTCCTCTTCTTCCTCGGCGTGTGGCTGGTAGCCTATGGCGTGGCCACGGAGGGGCTCCTGAGGCCACGGGACAGTGACTTCCCAAGTA
TCCTGCGCCGCGTCTTCTACCGTCCCTACCTGCAGATCTTCGGGCAGATTCCCCAGGAGGACATGGACGTGGCCCTCATGGAGCACAGCA
ACTGCTCGTCGGAGCCCGGCTTCTGGGCACACCCTCCTGGGGCCCAGGCGGGCACCTGCGTCTCCCAGTATGCCAACTGGCTGGTGGTGC
TGCTCCTCGTCATCTTCCTGCTCGTGGCCAACATCCTGCTGGTCAACTTGCTCATTGCCATGTTCAGTTACACATTCGGCAAAGTACAGG
GCAACAGCGATCTCTACTGGAAGGCGCAGCGTTACCGCCTCATCCGGGAATTCCACTCTCGGCCCGCGCTGGCCCCGCCCTTTATCGTCA
TCTCCCACTTGCGCCTCCTGCTCAGGCAATTGTGCAGGCGACCCCGGAGCCCCCAGCCGTCCTCCCCGGCCCTCGAGCATTTCCGGGTTT
ACCTTTCTAAGGAAGCCGAGCGGAAGCTGCTAACGTGGGAATCGGTGCATAAGGAGAACTTTCTGCTGGCACGCGCTAGGGACAAGCGGG
AGAGCGACTCCGAGCGTCTGAAGCGCACGTCCCAGAAGGTGGACTTGGCACTGAAACAGCTGGGACACATCCGCGAGTACGAACAGCGCC
TGAAAGTGCTGGAGCGGGAGGTCCAGCAGTGTAGCCGCGTCCTGGGGTGGGTGGCCGAGGCCCTGAGCCGCTCTGCCTTGCTGCCCCCAG
GTGGGCCGCCACCCCCTGACCTGCCTGGGTCCAAAGACTGAGCCCTGCTGGCGGACTTCAAGGAGAAGCCCCCACAGGGGATTTTGCTCC
TAGAGTAAGGCTCATCTGGGCCTCGGCCCCCGCACCTGGTGGCCTTGTCCTTGAGGTGAGCCCCATGTCCATCTGGGCCACTGTCAGGAC
CACCTTTGGGAGTGTCATCCTTACAAACCACAGCATGCCCGGCTCCTCCCAGAACCAGTCCCAGCCTGGGAGGATCAAGGCCTGGATCCC
GGGCCGTTATCCATCTGGAGGCTGCAGGGTCCTTGGGGTAACAGGGACCACAGACCCCTCACCACTCACAGATTCCTCACACTGGGGAAA

>In-frame_ENST00000312865_ENST00000252826_TCGA-D1-A1NU-01A_MED25_chr19_50322553_+_TRPM4_chr19_49669298_length(amino acids)=1285AA_start in transcript=53_stop in transcript=3910
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS
AYEFVTWLDGIKGTLCQCGRPRTAHPAVAMEDAFGAAVVTVWDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRT
WGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDT
LINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIE
NATQAQLPCLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKELLTVYSSEDGSEEFETIVLK
ALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPS
NSLIRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKATSPLSLDAGLGQAPW
SDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLW
GDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTREELEFDMDSVINGEGPVGTA
DPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEEL
RQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPK
IVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAG
TCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSP
QPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWV

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>In-frame_ENST00000312865_ENST00000427978_TCGA-D1-A1NU-01A_MED25_chr19_50322553_+_TRPM4_chr19_49669298_length(transcript)=3658nt_BP=358nt
ATTCCGCGGCGTCGGCTGCGGCTGCAGTGGTGGTGGCGGGTACCGCACGGGGTATGGTCCCCGGGTCCGAGGGCCCGGCCCGCGCCGGGA
GCGTGGTGGCCGACGTGGTGTTTGTGATTGAGGGTACGGCCAACCTGGGACCCTACTTCGAGGGGCTCCGCAAGCACTACCTGCTCCCGG
CCATCGAGTATTTTAATGGTGGTCCTCCTGCTGAGACGGACTTCGGGGGAGACTATGGGGGGACCCAGTACAGCCTCGTGGTGTTCAACA
CAGTGGACTGCGCTCCCGAGTCCTACGTACAATGTCACGCTCCCACCAGCAGCGCCTATGAGTTTGTCACCTGGCTCGATGGCATTAAAG
GGACCTTGTGCCAGTGTGGGCGCCCCCGGACCGCCCACCCCGCAGTGGCCATGGAGGATGCCTTCGGGGCAGCCGTGGTGACCGTGTGGG
ACAGCGATGCACACACCACGGAGAAGCCCACCGATGCCTACGGAGAGCTGGACTTCACGGGGGCCGGCCGCAAGCACAGCAATTTCCTCC
GGCTCTCTGACCGAACGGATCCAGCTGCAGTTTATAGTCTGGTCACACGCACATGGGGCTTCCGTGCCCCGAACCTGGTGGTGTCAGTGC
TGGGGGGATCGGGGGGCCCCGTCCTCCAGACCTGGCTGCAGGACCTGCTGCGTCGTGGGCTGGTGCGGGCTGCCCAGAGCACAGGAGCCT
GGATTGTCACTGGGGGTCTGCACACGGGCATCGGCCGGCATGTTGGTGTGGCTGTACGGGACCATCAGATGGCCAGCACTGGGGGCACCA
AGGTGGTGGCCATGGGTGTGGCCCCCTGGGGTGTGGTCCGGAATAGAGACACCCTCATCAACCCCAAGGGCTCGTTCCCTGCGAGGTACC
GGTGGCGCGGTGACCCGGAGGACGGGGTCCAGTTTCCCCTGGACTACAACTACTCGGCCTTCTTCCTGGTGGACGACGGCACACACGGCT
GCCTGGGGGGCGAGAACCGCTTCCGCTTGCGCCTGGAGTCCTACATCTCACAGCAGAAGACGGGCGTGGGAGGGACTGGAATTGACATCC
CTGTCCTGCTCCTCCTGATTGATGGTGATGAGAAGATGTTGACGCGAATAGAGAACGCCACCCAGGCTCAGCTCCCATGTCTCCTCGTGG
CTGGCTCAGGGGGAGCTGCGGACTGCCTGGCGGAGACCCTGGAAGACACTCTGGCCCCAGGGAGTGGGGGAGCCAGGCAAGGCGAAGCCC
GAGATCGAATCAGGCGTTTCTTTCCCAAAGGGGACCTTGAGGTCCTGCAGGCCCAGGTGGAGAGGATTATGACCCGGAAGGAGCTCCTGA
CAGTCTATTCTTCTGAGGATGGGTCTGAGGAATTCGAGACCATAGTTTTGAAGGCCCTTGTGAAGGCCTGTGGGAGCTCGGAGGCCTCAG
CCTACCTGGATGAGCTGCGTTTGGCTGTGGCTTGGAACCGCGTGGACATTGCCCAGAGTGAACTCTTTCGGGGGGACATCCAATGGCGGT
CCTTCCATCTCGAAGCTTCCCTCATGGACGCCCTGCTGAATGACCGGCCTGAGTTCGTGCGCTTGCTCATTTCCCACGGCCTCAGCCTGG
GCCACTTCCTGACCCCGATGCGCCTGGCCCAACTCTACAGCGCGGCGCCCTCCAACTCGCTCATCCGCAACCTTTTGGACCAGGCGTCCC
ACAGCGCAGGCACCAAAGCCCCAGCCCTAAAAGGGGGAGCTGCGGAGCTCCGGCCCCCTGACGTGGGGCATGTGCTGAGGATGCTGCTGG
GGAAGATGTGCGCGCCGAGGTACCCCTCCGGGGGCGCCTGGGACCCTCACCCAGGCCAGGGCTTCGGGGAGAGCATGTATCTGCTCTCGG
ACAAGGCCACCTCGCCGCTCTCGCTGGATGCTGGCCTCGGGCAGGCCCCCTGGAGCGACCTGCTTCTTTGGGCACTGTTGCTGAACAGGG
CACAGATGGCCATGTACTTCTGGGAGATGGGTTCCAATGCAGTTTCCTCAGCTCTTGGGGCCTGTTTGCTGCTCCGGGTGATGGCACGCC
TGGAGCCTGACGCTGAGGAGGCAGCACGGAGGAAAGACCTGGCGTTCAAGTTTGAGGGGATGGGCGTTGACCTCTTTGGCGAGTGCTATC
GCAGCAGTGAGGTGAGGGCTGCCCGCCTCCTCCTCCGTCGCTGCCCGCTCTGGGGGGATGCCACTTGCCTCCAGCTGGCCATGCAAGCTG
ACGCCCGTGCCTTCTTTGCCCAGGATGGGGTACAGTCTCTGCTGACACAGAAGTGGTGGGGAGATATGGCCAGCACTACACCCATCTGGG
CCCTGGTTCTCGCCTTCTTTTGCCCTCCACTCATCTACACCCGCCTCATCACCTTCAGGAAATCAGAAGAGGAGCCCACACGGGAGGAGC
TAGAGTTTGACATGGATAGTGTCATTAATGGGGAAGGGCCTGTCGGGCTGACCCCGGGTTTGTACCACCTGGGCCGCACTGTCCTCTGCA
TCGACTTCATGGTTTTCACGGTGCGGCTGCTTCACATCTTCACGGTCAACAAACAGCTGGGGCCCAAGATCGTCATCGTGAGCAAGATGA
TGAAGGACGTGTTCTTCTTCCTCTTCTTCCTCGGCGTGTGGCTGGTAGCCTATGGCGTGGCCACGGAGGGGCTCCTGAGGCCACGGGACA
GTGACTTCCCAAGTATCCTGCGCCGCGTCTTCTACCGTCCCTACCTGCAGATCTTCGGGCAGATTCCCCAGGAGGACATGGACGTGGCCC
TCATGGAGCACAGCAACTGCTCGTCGGAGCCCGGCTTCTGGGCACACCCTCCTGGGGCCCAGGCGGGCACCTGCGTCTCCCAGTATGCCA
ACTGGCTGGTGGTGCTGCTCCTCGTCATCTTCCTGCTCGTGGCCAACATCCTGCTGGTCAACTTGCTCATTGCCATGTTCAGTTACACAT
TCGGCAAAGTACAGGGCAACAGCGATCTCTACTGGAAGGCGCAGCGTTACCGCCTCATCCGGGAATTCCACTCTCGGCCCGCGCTGGCCC
CGCCCTTTATCGTCATCTCCCACTTGCGCCTCCTGCTCAGGCAATTGTGCAGGCGACCCCGGAGCCCCCAGCCGTCCTCCCCGGCCCTCG
AGCATTTCCGGGTTTACCTTTCTAAGGAAGCCGAGCGGAAGCTGCTAACGTGGGAATCGGTGCATAAGGAGAACTTTCTGCTGGCACGCG
CTAGGGACAAGCGGGAGAGCGACTCCGAGCGTCTGAAGCGCACGTCCCAGAAGGTGGACTTGGCACTGAAACAGCTGGGACACATCCGCG
AGTACGAACAGCGCCTGAAAGTGCTGGAGCGGGAGGTCCAGCAGTGTAGCCGCGTCCTGGGGTGGGTGGCCGAGGCCCTGAGCCGCTCTG
CCTTGCTGCCCCCAGGTGGGCCGCCACCCCCTGACCTGCCTGGGTCCAAAGACTGAGCCCTGCTGGCGGACTTCAAGGAGAAGCCCCCAC
AGGGGATTTTGCTCCTAGAGTAAGGCTCATCTGGGCCTCGGCCCCCGCACCTGGTGGCCTTGTCCTTGAGGTGAGCCCCATGTCCATCTG

>In-frame_ENST00000312865_ENST00000427978_TCGA-D1-A1NU-01A_MED25_chr19_50322553_+_TRPM4_chr19_49669298_length(amino acids)=1140AA_start in transcript=53_stop in transcript=3475
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSS
AYEFVTWLDGIKGTLCQCGRPRTAHPAVAMEDAFGAAVVTVWDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRT
WGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDT
LINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIE
NATQAQLPCLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKELLTVYSSEDGSEEFETIVLK
ALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPS
NSLIRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKATSPLSLDAGLGQAPW
SDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLW
GDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTREELEFDMDSVINGEGPVGLT
PGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQI
FGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYR
LIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQK

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Fusion Gene PPI Analysis for MED25-TRPM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMED25chr19:50322553chr19:49669298ENST00000312865+318395_545101.66666666666667748.0CREBBP
HgeneMED25chr19:50322553chr19:49669298ENST00000538643+113395_5450.0535.0CREBBP
HgeneMED25chr19:50322553chr19:49669298ENST00000312865+318564_653101.66666666666667748.0RARA
HgeneMED25chr19:50322553chr19:49669298ENST00000312865+318640_707101.66666666666667748.0RARA
HgeneMED25chr19:50322553chr19:49669298ENST00000538643+113564_6530.0535.0RARA
HgeneMED25chr19:50322553chr19:49669298ENST00000538643+113640_7070.0535.0RARA
HgeneMED25chr19:50322553chr19:49669298ENST00000312865+3181_226101.66666666666667748.0the Mediator complex
HgeneMED25chr19:50322553chr19:49669298ENST00000538643+1131_2260.0535.0the Mediator complex
HgeneMED25chr19:50322553chr19:49669298ENST00000312865+318389_543101.66666666666667748.0VP16
HgeneMED25chr19:50322553chr19:49669298ENST00000538643+113389_5430.0535.0VP16


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MED25-TRPM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MED25-TRPM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMED25C4225323BASEL-VANAGAITE-SMIRIN-YOSEF SYNDROME3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneMED25C1854150Charcot-Marie-Tooth disease, Type 2B21CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTRPM4C1142166Brugada Syndrome (disorder)7CLINGEN;ORPHANET
TgeneTRPM4C1970298Progressive Familial Heart Block, Type Ib6CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTRPM4C1879286Hereditary bundle branch system defect2ORPHANET
TgeneTRPM4C0033578Prostatic Neoplasms1CTD_human
TgeneTRPM4C0265961Erythrokeratodermia variabilis1ORPHANET
TgeneTRPM4C0376358Malignant neoplasm of prostate1CTD_human