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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MET-C8orf34 (FusionGDB2 ID:52687)

Fusion Gene Summary for MET-C8orf34

check button Fusion gene summary
Fusion gene informationFusion gene name: MET-C8orf34
Fusion gene ID: 52687
HgeneTgene
Gene symbol

MET

C8orf34

Gene ID

8731

116328

Gene nameRNA guanine-7 methyltransferasechromosome 8 open reading frame 34
SynonymsCMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMetVEST-1|VEST1
Cytomap

18p11.21

8q13.2

Type of geneprotein-codingprotein-coding
DescriptionmRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferaseuncharacterized protein C8orf34protein VEST-1vestibule-1 protein
Modification date2020032920200313
UniProtAcc.

Q49A92

Ensembl transtripts involved in fusion geneENST00000397752, ENST00000318493, 
ENST00000436117, ENST00000495962, 
ENST00000539704, 		ENST00000539993, 
ENST00000518698, ENST00000349492, 
ENST00000523686, ENST00000348340, 
ENST00000337103, ENST00000325233, 
Fusion gene scores* DoF score11 X 10 X 9=99012 X 12 X 9=1296
# samples 1613
** MAII scorelog2(16/990*10)=-2.62935662007961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1296*10)=-3.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MET [Title/Abstract] AND C8orf34 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC8orf34(69351881)-MET(116414935), # samples:3
MET(116412043)-C8orf34(69358564), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871


check buttonFusion gene breakpoints across MET (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across C8orf34 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-GL-7773-01AMETchr7

116412043

+C8orf34chr8

69358564

+
ChimerDB4KIRPTCGA-GL-7773METchr7

116412043

+C8orf34chr8

69358563

+
ChimerDB4KIRPTCGA-GL-7773METchr7

116412043

+C8orf34chr8

69358564

+
ChimerDB4KIRPTCGA-GL-7773-01AMETchr7

116412043

-C8orf34chr8

69358564

+


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Fusion Gene ORF analysis for MET-C8orf34

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000397752ENST00000539993METchr7

116412043

+C8orf34chr8

69358564

+
In-frameENST00000397752ENST00000518698METchr7

116412043

+C8orf34chr8

69358564

+
5CDS-3UTRENST00000397752ENST00000349492METchr7

116412043

+C8orf34chr8

69358564

+
5CDS-3UTRENST00000397752ENST00000523686METchr7

116412043

+C8orf34chr8

69358564

+
5CDS-3UTRENST00000397752ENST00000348340METchr7

116412043

+C8orf34chr8

69358564

+
5CDS-3UTRENST00000397752ENST00000337103METchr7

116412043

+C8orf34chr8

69358564

+
5CDS-intronENST00000397752ENST00000325233METchr7

116412043

+C8orf34chr8

69358564

+
In-frameENST00000318493ENST00000539993METchr7

116412043

+C8orf34chr8

69358564

+
In-frameENST00000318493ENST00000518698METchr7

116412043

+C8orf34chr8

69358564

+
5CDS-3UTRENST00000318493ENST00000349492METchr7

116412043

+C8orf34chr8

69358564

+
5CDS-3UTRENST00000318493ENST00000523686METchr7

116412043

+C8orf34chr8

69358564

+
5CDS-3UTRENST00000318493ENST00000348340METchr7

116412043

+C8orf34chr8

69358564

+
5CDS-3UTRENST00000318493ENST00000337103METchr7

116412043

+C8orf34chr8

69358564

+
5CDS-intronENST00000318493ENST00000325233METchr7

116412043

+C8orf34chr8

69358564

+
intron-3CDSENST00000436117ENST00000539993METchr7

116412043

+C8orf34chr8

69358564

+
intron-3CDSENST00000436117ENST00000518698METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000436117ENST00000349492METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000436117ENST00000523686METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000436117ENST00000348340METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000436117ENST00000337103METchr7

116412043

+C8orf34chr8

69358564

+
intron-intronENST00000436117ENST00000325233METchr7

116412043

+C8orf34chr8

69358564

+
intron-3CDSENST00000495962ENST00000539993METchr7

116412043

+C8orf34chr8

69358564

+
intron-3CDSENST00000495962ENST00000518698METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000495962ENST00000349492METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000495962ENST00000523686METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000495962ENST00000348340METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000495962ENST00000337103METchr7

116412043

+C8orf34chr8

69358564

+
intron-intronENST00000495962ENST00000325233METchr7

116412043

+C8orf34chr8

69358564

+
intron-3CDSENST00000539704ENST00000539993METchr7

116412043

+C8orf34chr8

69358564

+
intron-3CDSENST00000539704ENST00000518698METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000539704ENST00000349492METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000539704ENST00000523686METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000539704ENST00000348340METchr7

116412043

+C8orf34chr8

69358564

+
intron-3UTRENST00000539704ENST00000337103METchr7

116412043

+C8orf34chr8

69358564

+
intron-intronENST00000539704ENST00000325233METchr7

116412043

+C8orf34chr8

69358564

+
In-frameENST00000397752ENST00000539993METchr7

116412043

+C8orf34chr8

69358563

+
In-frameENST00000397752ENST00000518698METchr7

116412043

+C8orf34chr8

69358563

+
5CDS-3UTRENST00000397752ENST00000349492METchr7

116412043

+C8orf34chr8

69358563

+
5CDS-3UTRENST00000397752ENST00000523686METchr7

116412043

+C8orf34chr8

69358563

+
5CDS-3UTRENST00000397752ENST00000348340METchr7

116412043

+C8orf34chr8

69358563

+
5CDS-3UTRENST00000397752ENST00000337103METchr7

116412043

+C8orf34chr8

69358563

+
5CDS-intronENST00000397752ENST00000325233METchr7

116412043

+C8orf34chr8

69358563

+
In-frameENST00000318493ENST00000539993METchr7

116412043

+C8orf34chr8

69358563

+
In-frameENST00000318493ENST00000518698METchr7

116412043

+C8orf34chr8

69358563

+
5CDS-3UTRENST00000318493ENST00000349492METchr7

116412043

+C8orf34chr8

69358563

+
5CDS-3UTRENST00000318493ENST00000523686METchr7

116412043

+C8orf34chr8

69358563

+
5CDS-3UTRENST00000318493ENST00000348340METchr7

116412043

+C8orf34chr8

69358563

+
5CDS-3UTRENST00000318493ENST00000337103METchr7

116412043

+C8orf34chr8

69358563

+
5CDS-intronENST00000318493ENST00000325233METchr7

116412043

+C8orf34chr8

69358563

+
intron-3CDSENST00000436117ENST00000539993METchr7

116412043

+C8orf34chr8

69358563

+
intron-3CDSENST00000436117ENST00000518698METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000436117ENST00000349492METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000436117ENST00000523686METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000436117ENST00000348340METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000436117ENST00000337103METchr7

116412043

+C8orf34chr8

69358563

+
intron-intronENST00000436117ENST00000325233METchr7

116412043

+C8orf34chr8

69358563

+
intron-3CDSENST00000495962ENST00000539993METchr7

116412043

+C8orf34chr8

69358563

+
intron-3CDSENST00000495962ENST00000518698METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000495962ENST00000349492METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000495962ENST00000523686METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000495962ENST00000348340METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000495962ENST00000337103METchr7

116412043

+C8orf34chr8

69358563

+
intron-intronENST00000495962ENST00000325233METchr7

116412043

+C8orf34chr8

69358563

+
intron-3CDSENST00000539704ENST00000539993METchr7

116412043

+C8orf34chr8

69358563

+
intron-3CDSENST00000539704ENST00000518698METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000539704ENST00000349492METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000539704ENST00000523686METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000539704ENST00000348340METchr7

116412043

+C8orf34chr8

69358563

+
intron-3UTRENST00000539704ENST00000337103METchr7

116412043

+C8orf34chr8

69358563

+
intron-intronENST00000539704ENST00000325233METchr7

116412043

+C8orf34chr8

69358563

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397752METchr7116412043+ENST00000539993C8orf34chr869358564+4679322820043691389
ENST00000397752METchr7116412043+ENST00000518698C8orf34chr869358564+4685322820043691389
ENST00000318493METchr7116412043+ENST00000539993C8orf34chr869358564+4720326918744101407
ENST00000318493METchr7116412043+ENST00000518698C8orf34chr869358564+4726326918744101407
ENST00000397752METchr7116412043+ENST00000539993C8orf34chr869358563+4679322820043691389
ENST00000397752METchr7116412043+ENST00000518698C8orf34chr869358563+4685322820043691389
ENST00000318493METchr7116412043+ENST00000539993C8orf34chr869358563+4720326918744101407
ENST00000318493METchr7116412043+ENST00000518698C8orf34chr869358563+4726326918744101407

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397752ENST00000539993METchr7116412043+C8orf34chr869358564+0.0004226640.99957734
ENST00000397752ENST00000518698METchr7116412043+C8orf34chr869358564+0.000421050.9995789
ENST00000318493ENST00000539993METchr7116412043+C8orf34chr869358564+0.0001037880.99989617
ENST00000318493ENST00000518698METchr7116412043+C8orf34chr869358564+0.0001027410.99989724
ENST00000397752ENST00000539993METchr7116412043+C8orf34chr869358563+0.0004226640.99957734
ENST00000397752ENST00000518698METchr7116412043+C8orf34chr869358563+0.000421050.9995789
ENST00000318493ENST00000539993METchr7116412043+C8orf34chr869358563+0.0001037880.99989617
ENST00000318493ENST00000518698METchr7116412043+C8orf34chr869358563+0.0001027410.99989724

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Fusion Genomic Features for MET-C8orf34


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MET-C8orf34


check button Go to

FGviewer for the breakpoints of chr7:116412043-chr8:69358564

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.C8orf34

Q49A92

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMETchr7:116412043chr8:69358563ENST00000318493+142127_5151027.33333333333331409.0DomainSema
HgeneMETchr7:116412043chr8:69358563ENST00000318493+1421563_6551027.33333333333331409.0DomainNote=IPT/TIG 1
HgeneMETchr7:116412043chr8:69358563ENST00000318493+1421657_7391027.33333333333331409.0DomainNote=IPT/TIG 2
HgeneMETchr7:116412043chr8:69358563ENST00000318493+1421742_8361027.33333333333331409.0DomainNote=IPT/TIG 3
HgeneMETchr7:116412043chr8:69358563ENST00000397752+142127_5151009.33333333333341391.0DomainSema
HgeneMETchr7:116412043chr8:69358563ENST00000397752+1421563_6551009.33333333333341391.0DomainNote=IPT/TIG 1
HgeneMETchr7:116412043chr8:69358563ENST00000397752+1421657_7391009.33333333333341391.0DomainNote=IPT/TIG 2
HgeneMETchr7:116412043chr8:69358563ENST00000397752+1421742_8361009.33333333333341391.0DomainNote=IPT/TIG 3
HgeneMETchr7:116412043chr8:69358564ENST00000318493+142127_5151027.33333333333331409.0DomainSema
HgeneMETchr7:116412043chr8:69358564ENST00000318493+1421563_6551027.33333333333331409.0DomainNote=IPT/TIG 1
HgeneMETchr7:116412043chr8:69358564ENST00000318493+1421657_7391027.33333333333331409.0DomainNote=IPT/TIG 2
HgeneMETchr7:116412043chr8:69358564ENST00000318493+1421742_8361027.33333333333331409.0DomainNote=IPT/TIG 3
HgeneMETchr7:116412043chr8:69358564ENST00000397752+142127_5151009.33333333333341391.0DomainSema
HgeneMETchr7:116412043chr8:69358564ENST00000397752+1421563_6551009.33333333333341391.0DomainNote=IPT/TIG 1
HgeneMETchr7:116412043chr8:69358564ENST00000397752+1421657_7391009.33333333333341391.0DomainNote=IPT/TIG 2
HgeneMETchr7:116412043chr8:69358564ENST00000397752+1421742_8361009.33333333333341391.0DomainNote=IPT/TIG 3
HgeneMETchr7:116412043chr8:69358563ENST00000318493+142125_9321027.33333333333331409.0Topological domainExtracellular
HgeneMETchr7:116412043chr8:69358563ENST00000397752+142125_9321009.33333333333341391.0Topological domainExtracellular
HgeneMETchr7:116412043chr8:69358564ENST00000318493+142125_9321027.33333333333331409.0Topological domainExtracellular
HgeneMETchr7:116412043chr8:69358564ENST00000397752+142125_9321009.33333333333341391.0Topological domainExtracellular
HgeneMETchr7:116412043chr8:69358563ENST00000318493+1421933_9551027.33333333333331409.0TransmembraneHelical
HgeneMETchr7:116412043chr8:69358563ENST00000397752+1421933_9551009.33333333333341391.0TransmembraneHelical
HgeneMETchr7:116412043chr8:69358564ENST00000318493+1421933_9551027.33333333333331409.0TransmembraneHelical
HgeneMETchr7:116412043chr8:69358564ENST00000397752+1421933_9551009.33333333333341391.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMETchr7:116412043chr8:69358563ENST00000318493+14211078_13451027.33333333333331409.0DomainProtein kinase
HgeneMETchr7:116412043chr8:69358563ENST00000397752+14211078_13451009.33333333333341391.0DomainProtein kinase
HgeneMETchr7:116412043chr8:69358563ENST00000436117+191078_13450.0765.0DomainProtein kinase
HgeneMETchr7:116412043chr8:69358563ENST00000436117+1927_5150.0765.0DomainSema
HgeneMETchr7:116412043chr8:69358563ENST00000436117+19563_6550.0765.0DomainNote=IPT/TIG 1
HgeneMETchr7:116412043chr8:69358563ENST00000436117+19657_7390.0765.0DomainNote=IPT/TIG 2
HgeneMETchr7:116412043chr8:69358563ENST00000436117+19742_8360.0765.0DomainNote=IPT/TIG 3
HgeneMETchr7:116412043chr8:69358564ENST00000318493+14211078_13451027.33333333333331409.0DomainProtein kinase
HgeneMETchr7:116412043chr8:69358564ENST00000397752+14211078_13451009.33333333333341391.0DomainProtein kinase
HgeneMETchr7:116412043chr8:69358564ENST00000436117+191078_13450.0765.0DomainProtein kinase
HgeneMETchr7:116412043chr8:69358564ENST00000436117+1927_5150.0765.0DomainSema
HgeneMETchr7:116412043chr8:69358564ENST00000436117+19563_6550.0765.0DomainNote=IPT/TIG 1
HgeneMETchr7:116412043chr8:69358564ENST00000436117+19657_7390.0765.0DomainNote=IPT/TIG 2
HgeneMETchr7:116412043chr8:69358564ENST00000436117+19742_8360.0765.0DomainNote=IPT/TIG 3
HgeneMETchr7:116412043chr8:69358563ENST00000318493+14211084_10921027.33333333333331409.0Nucleotide bindingATP
HgeneMETchr7:116412043chr8:69358563ENST00000397752+14211084_10921009.33333333333341391.0Nucleotide bindingATP
HgeneMETchr7:116412043chr8:69358563ENST00000436117+191084_10920.0765.0Nucleotide bindingATP
HgeneMETchr7:116412043chr8:69358564ENST00000318493+14211084_10921027.33333333333331409.0Nucleotide bindingATP
HgeneMETchr7:116412043chr8:69358564ENST00000397752+14211084_10921009.33333333333341391.0Nucleotide bindingATP
HgeneMETchr7:116412043chr8:69358564ENST00000436117+191084_10920.0765.0Nucleotide bindingATP
HgeneMETchr7:116412043chr8:69358563ENST00000318493+1421956_13901027.33333333333331409.0Topological domainCytoplasmic
HgeneMETchr7:116412043chr8:69358563ENST00000397752+1421956_13901009.33333333333341391.0Topological domainCytoplasmic
HgeneMETchr7:116412043chr8:69358563ENST00000436117+1925_9320.0765.0Topological domainExtracellular
HgeneMETchr7:116412043chr8:69358563ENST00000436117+19956_13900.0765.0Topological domainCytoplasmic
HgeneMETchr7:116412043chr8:69358564ENST00000318493+1421956_13901027.33333333333331409.0Topological domainCytoplasmic
HgeneMETchr7:116412043chr8:69358564ENST00000397752+1421956_13901009.33333333333341391.0Topological domainCytoplasmic
HgeneMETchr7:116412043chr8:69358564ENST00000436117+1925_9320.0765.0Topological domainExtracellular
HgeneMETchr7:116412043chr8:69358564ENST00000436117+19956_13900.0765.0Topological domainCytoplasmic
HgeneMETchr7:116412043chr8:69358563ENST00000436117+19933_9550.0765.0TransmembraneHelical
HgeneMETchr7:116412043chr8:69358564ENST00000436117+19933_9550.0765.0TransmembraneHelical


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Fusion Gene Sequence for MET-C8orf34


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000397752_ENST00000539993_TCGA-GL-7773-01A_MET_chr7_116412043_+_C8orf34_chr8_69358564_length(transcript)=4679nt_BP=3228nt
AGGTGACCCGGAGGCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGG
GCGACAGCTGACTTGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCAC
CGAAAGATAAACCTCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATG
GGGAGTGTAAAGAGGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGA
ATGTCATTCTACATGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGT
ACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAG
ATAACATCAACATGGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGAC
ATGTCTTTCCCCACAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTG
ACTGTGTGGTGAGCGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTT
CTTATTTCCCAGATCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCT
ACATTGATGTTTTACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGG
TCCAAAGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAA
TGCCTCTGGAGTGTATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCA
AGCCTGGGGCCCAGCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTG
CCGAACCAATGGATCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGA
GATGTCTCCAGCATTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTG
ATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCA
CCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAA
CCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGG
TTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCAC
CCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTG
CAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATA
ATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAAT
GCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCT
ATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACA
GTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCC
AAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTG
TCTATGAAATTCATCCAACCAAATCTTTTATTAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGA
GAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTC
CTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCA
TTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATG
ATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTAT
GCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAA
TAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGT
GGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTG
TAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAA
CAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAAGAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATA
TTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCATCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATT
TTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGCCCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAAC
TCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGTGATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATC
CCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGACCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAA
GCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCAACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTT
TTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGATAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATG
ATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATTTAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCA
AGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAACCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATT
CTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGAAGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCAT
CTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACTGAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGC
AGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGGAGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTC
TTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTGAAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGC
AGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAATCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAAC
AAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACTAATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTG

>In-frame_ENST00000397752_ENST00000539993_TCGA-GL-7773-01A_MET_chr7_116412043_+_C8orf34_chr8_69358564_length(amino acids)=1389AA_start in transcript=200_stop in transcript=4369
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL
TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM
NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLN
LQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVS
PTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPKWNWRTKPQSRDFDELNHI
LQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQWESEDSGSSPAGSLKMEPK
NKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQGRPTYPAEPQAKVTLNIC
SRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKNYMEEDESLKQLQVVHQPW

--------------------------------------------------------------
>In-frame_ENST00000397752_ENST00000518698_TCGA-GL-7773-01A_MET_chr7_116412043_+_C8orf34_chr8_69358564_length(transcript)=4685nt_BP=3228nt
AGGTGACCCGGAGGCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGG
GCGACAGCTGACTTGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCAC
CGAAAGATAAACCTCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATG
GGGAGTGTAAAGAGGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGA
ATGTCATTCTACATGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGT
ACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAG
ATAACATCAACATGGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGAC
ATGTCTTTCCCCACAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTG
ACTGTGTGGTGAGCGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTT
CTTATTTCCCAGATCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCT
ACATTGATGTTTTACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGG
TCCAAAGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAA
TGCCTCTGGAGTGTATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCA
AGCCTGGGGCCCAGCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTG
CCGAACCAATGGATCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGA
GATGTCTCCAGCATTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTG
ATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCA
CCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAA
CCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGG
TTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCAC
CCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTG
CAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATA
ATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAAT
GCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCT
ATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACA
GTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCC
AAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTG
TCTATGAAATTCATCCAACCAAATCTTTTATTAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGA
GAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTC
CTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCA
TTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATG
ATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTAT
GCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAA
TAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGT
GGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTG
TAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAA
CAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAAGAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATA
TTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCATCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATT
TTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGCCCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAAC
TCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGTGATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATC
CCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGACCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAA
GCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCAACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTT
TTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGATAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATG
ATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATTTAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCA
AGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAACCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATT
CTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGAAGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCAT
CTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACTGAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGC
AGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGGAGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTC
TTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTGAAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGC
AGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAATCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAAC
AAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACTAATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTG
CCTTTTGACATGGTTAGAGTCCTGGGTTTAGATTACTTTATAAATAGTTATTAAGATTAATATTTGATATATTAAATATTGCCTGATTCA

>In-frame_ENST00000397752_ENST00000518698_TCGA-GL-7773-01A_MET_chr7_116412043_+_C8orf34_chr8_69358564_length(amino acids)=1389AA_start in transcript=200_stop in transcript=4369
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL
TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM
NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLN
LQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVS
PTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPKWNWRTKPQSRDFDELNHI
LQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQWESEDSGSSPAGSLKMEPK
NKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQGRPTYPAEPQAKVTLNIC
SRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKNYMEEDESLKQLQVVHQPW

--------------------------------------------------------------
>In-frame_ENST00000318493_ENST00000539993_TCGA-GL-7773-01A_MET_chr7_116412043_+_C8orf34_chr8_69358564_length(transcript)=4720nt_BP=3269nt
GCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGGGCGACAGCTGACT
TGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCACCGAAAGATAAACC
TCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGA
GGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACA
TGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCC
TGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACAT
GGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCA
CAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAG
CGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGA
TCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTT
ACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAAC
TCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTG
TATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCA
GCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGA
TCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCA
TTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTGATGAATATCGAAC
AGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCACCTTCATTAAAGG
AGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAACCCCTCATGTGAA
TTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGGTTATCACTGGGAA
GAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCACCCTTTGTTCAGTG
TGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTGCAATCTACAAGGT
TTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATAATAAATTTGATTT
AAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAATGCACAGTTGGTCC
TGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCTATGTGGATCCTGT
AATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACAGTGGGAATTCTAG
ACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCCAAACCATTTCAAC
TGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTGTCTATGAAATTCA
TCCAACCAAATCTTTTATTAGTACTTGGTGGAAAGAACCTCTCAACATTGTCAGTTTTCTATTTTGCTTTGCCAGTGGTGGGAGCACAAT
AACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATG
TCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTT
TTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGAT
CTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAA
GAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGA
GTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTC
AATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCG
CTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATC
TGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAACAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAA
GAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATATTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCA
TCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATTTTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGC
CCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAACTCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGT
GATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATCCCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGA
CCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAAGCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCA
ACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTTTTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGA
TAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATGATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATT
TAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCAAGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAA
CCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATTCTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGA
AGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCATCTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACT
GAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGCAGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGG
AGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTCTTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTG
AAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGCAGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAA
TCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAACAAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACT
AATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTGCCTTTTGACATGGTTAGAGTCCTGGGTTTAGATTACTTTATAAATAGTT

>In-frame_ENST00000318493_ENST00000539993_TCGA-GL-7773-01A_MET_chr7_116412043_+_C8orf34_chr8_69358564_length(amino acids)=1407AA_start in transcript=187_stop in transcript=4410
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL
TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM
NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISTWWKEPLNIVSFLFCFASGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQH
RSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSC
ENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYD
ARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPK
WNWRTKPQSRDFDELNHILQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQW
ESEDSGSSPAGSLKMEPKNKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQ
GRPTYPAEPQAKVTLNICSRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKN

--------------------------------------------------------------
>In-frame_ENST00000318493_ENST00000518698_TCGA-GL-7773-01A_MET_chr7_116412043_+_C8orf34_chr8_69358564_length(transcript)=4726nt_BP=3269nt
GCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGGGCGACAGCTGACT
TGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCACCGAAAGATAAACC
TCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGA
GGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACA
TGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCC
TGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACAT
GGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCA
CAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAG
CGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGA
TCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTT
ACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAAC
TCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTG
TATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCA
GCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGA
TCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCA
TTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTGATGAATATCGAAC
AGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCACCTTCATTAAAGG
AGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAACCCCTCATGTGAA
TTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGGTTATCACTGGGAA
GAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCACCCTTTGTTCAGTG
TGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTGCAATCTACAAGGT
TTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATAATAAATTTGATTT
AAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAATGCACAGTTGGTCC
TGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCTATGTGGATCCTGT
AATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACAGTGGGAATTCTAG
ACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCCAAACCATTTCAAC
TGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTGTCTATGAAATTCA
TCCAACCAAATCTTTTATTAGTACTTGGTGGAAAGAACCTCTCAACATTGTCAGTTTTCTATTTTGCTTTGCCAGTGGTGGGAGCACAAT
AACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATG
TCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTT
TTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGAT
CTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAA
GAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGA
GTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTC
AATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCG
CTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATC
TGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAACAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAA
GAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATATTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCA
TCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATTTTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGC
CCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAACTCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGT
GATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATCCCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGA
CCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAAGCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCA
ACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTTTTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGA
TAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATGATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATT
TAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCAAGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAA
CCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATTCTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGA
AGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCATCTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACT
GAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGCAGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGG
AGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTCTTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTG
AAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGCAGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAA
TCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAACAAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACT
AATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTGCCTTTTGACATGGTTAGAGTCCTGGGTTTAGATTACTTTATAAATAGTT

>In-frame_ENST00000318493_ENST00000518698_TCGA-GL-7773-01A_MET_chr7_116412043_+_C8orf34_chr8_69358564_length(amino acids)=1407AA_start in transcript=187_stop in transcript=4410
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL
TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM
NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISTWWKEPLNIVSFLFCFASGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQH
RSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSC
ENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYD
ARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPK
WNWRTKPQSRDFDELNHILQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQW
ESEDSGSSPAGSLKMEPKNKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQ
GRPTYPAEPQAKVTLNICSRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKN

--------------------------------------------------------------
>In-frame_ENST00000397752_ENST00000539993_TCGA-GL-7773_MET_chr7_116412043_+_C8orf34_chr8_69358563_length(transcript)=4679nt_BP=3228nt
AGGTGACCCGGAGGCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGG
GCGACAGCTGACTTGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCAC
CGAAAGATAAACCTCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATG
GGGAGTGTAAAGAGGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGA
ATGTCATTCTACATGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGT
ACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAG
ATAACATCAACATGGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGAC
ATGTCTTTCCCCACAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTG
ACTGTGTGGTGAGCGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTT
CTTATTTCCCAGATCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCT
ACATTGATGTTTTACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGG
TCCAAAGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAA
TGCCTCTGGAGTGTATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCA
AGCCTGGGGCCCAGCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTG
CCGAACCAATGGATCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGA
GATGTCTCCAGCATTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTG
ATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCA
CCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAA
CCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGG
TTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCAC
CCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTG
CAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATA
ATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAAT
GCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCT
ATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACA
GTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCC
AAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTG
TCTATGAAATTCATCCAACCAAATCTTTTATTAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGA
GAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTC
CTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCA
TTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATG
ATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTAT
GCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAA
TAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGT
GGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTG
TAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAA
CAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAAGAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATA
TTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCATCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATT
TTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGCCCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAAC
TCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGTGATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATC
CCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGACCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAA
GCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCAACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTT
TTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGATAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATG
ATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATTTAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCA
AGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAACCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATT
CTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGAAGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCAT
CTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACTGAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGC
AGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGGAGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTC
TTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTGAAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGC
AGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAATCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAAC
AAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACTAATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTG

>In-frame_ENST00000397752_ENST00000539993_TCGA-GL-7773_MET_chr7_116412043_+_C8orf34_chr8_69358563_length(amino acids)=1389AA_start in transcript=200_stop in transcript=4369
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL
TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM
NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLN
LQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVS
PTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPKWNWRTKPQSRDFDELNHI
LQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQWESEDSGSSPAGSLKMEPK
NKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQGRPTYPAEPQAKVTLNIC
SRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKNYMEEDESLKQLQVVHQPW

--------------------------------------------------------------
>In-frame_ENST00000397752_ENST00000518698_TCGA-GL-7773_MET_chr7_116412043_+_C8orf34_chr8_69358563_length(transcript)=4685nt_BP=3228nt
AGGTGACCCGGAGGCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGG
GCGACAGCTGACTTGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCAC
CGAAAGATAAACCTCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATG
GGGAGTGTAAAGAGGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGA
ATGTCATTCTACATGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGT
ACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAG
ATAACATCAACATGGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGAC
ATGTCTTTCCCCACAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTG
ACTGTGTGGTGAGCGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTT
CTTATTTCCCAGATCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCT
ACATTGATGTTTTACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGG
TCCAAAGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAA
TGCCTCTGGAGTGTATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCA
AGCCTGGGGCCCAGCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTG
CCGAACCAATGGATCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGA
GATGTCTCCAGCATTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTG
ATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCA
CCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAA
CCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGG
TTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCAC
CCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTG
CAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATA
ATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAAT
GCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCT
ATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACA
GTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCC
AAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTG
TCTATGAAATTCATCCAACCAAATCTTTTATTAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGA
GAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTC
CTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCA
TTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATG
ATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTAT
GCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAA
TAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGT
GGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTG
TAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAA
CAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAAGAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATA
TTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCATCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATT
TTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGCCCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAAC
TCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGTGATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATC
CCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGACCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAA
GCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCAACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTT
TTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGATAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATG
ATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATTTAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCA
AGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAACCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATT
CTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGAAGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCAT
CTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACTGAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGC
AGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGGAGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTC
TTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTGAAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGC
AGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAATCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAAC
AAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACTAATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTG
CCTTTTGACATGGTTAGAGTCCTGGGTTTAGATTACTTTATAAATAGTTATTAAGATTAATATTTGATATATTAAATATTGCCTGATTCA

>In-frame_ENST00000397752_ENST00000518698_TCGA-GL-7773_MET_chr7_116412043_+_C8orf34_chr8_69358563_length(amino acids)=1389AA_start in transcript=200_stop in transcript=4369
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL
TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM
NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLN
LQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVS
PTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPKWNWRTKPQSRDFDELNHI
LQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQWESEDSGSSPAGSLKMEPK
NKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQGRPTYPAEPQAKVTLNIC
SRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKNYMEEDESLKQLQVVHQPW

--------------------------------------------------------------
>In-frame_ENST00000318493_ENST00000539993_TCGA-GL-7773_MET_chr7_116412043_+_C8orf34_chr8_69358563_length(transcript)=4720nt_BP=3269nt
GCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGGGCGACAGCTGACT
TGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCACCGAAAGATAAACC
TCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGA
GGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACA
TGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCC
TGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACAT
GGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCA
CAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAG
CGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGA
TCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTT
ACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAAC
TCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTG
TATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCA
GCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGA
TCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCA
TTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTGATGAATATCGAAC
AGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCACCTTCATTAAAGG
AGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAACCCCTCATGTGAA
TTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGGTTATCACTGGGAA
GAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCACCCTTTGTTCAGTG
TGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTGCAATCTACAAGGT
TTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATAATAAATTTGATTT
AAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAATGCACAGTTGGTCC
TGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCTATGTGGATCCTGT
AATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACAGTGGGAATTCTAG
ACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCCAAACCATTTCAAC
TGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTGTCTATGAAATTCA
TCCAACCAAATCTTTTATTAGTACTTGGTGGAAAGAACCTCTCAACATTGTCAGTTTTCTATTTTGCTTTGCCAGTGGTGGGAGCACAAT
AACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATG
TCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTT
TTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGAT
CTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAA
GAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGA
GTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTC
AATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCG
CTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATC
TGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAACAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAA
GAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATATTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCA
TCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATTTTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGC
CCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAACTCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGT
GATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATCCCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGA
CCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAAGCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCA
ACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTTTTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGA
TAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATGATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATT
TAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCAAGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAA
CCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATTCTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGA
AGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCATCTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACT
GAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGCAGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGG
AGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTCTTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTG
AAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGCAGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAA
TCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAACAAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACT
AATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTGCCTTTTGACATGGTTAGAGTCCTGGGTTTAGATTACTTTATAAATAGTT

>In-frame_ENST00000318493_ENST00000539993_TCGA-GL-7773_MET_chr7_116412043_+_C8orf34_chr8_69358563_length(amino acids)=1407AA_start in transcript=187_stop in transcript=4410
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL
TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM
NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISTWWKEPLNIVSFLFCFASGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQH
RSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSC
ENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYD
ARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPK
WNWRTKPQSRDFDELNHILQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQW
ESEDSGSSPAGSLKMEPKNKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQ
GRPTYPAEPQAKVTLNICSRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKN

--------------------------------------------------------------
>In-frame_ENST00000318493_ENST00000518698_TCGA-GL-7773_MET_chr7_116412043_+_C8orf34_chr8_69358563_length(transcript)=4726nt_BP=3269nt
GCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGGGCGACAGCTGACT
TGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCACCGAAAGATAAACC
TCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGA
GGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACA
TGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCC
TGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACAT
GGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCA
CAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAG
CGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGA
TCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTT
ACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAAC
TCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTG
TATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCA
GCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGA
TCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCA
TTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGACACTTCTGAGAAATTCATCAGGCTGTGAAGCGCGCCGTGATGAATATCGAAC
AGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAACATCTATATCCACCTTCATTAAAGG
AGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGATCAGGACCATCAACCCCTCATGTGAA
TTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATGGCTACACACTGGTTATCACTGGGAA
GAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCCTCTCTGCCCCACCCTTTGTTCAGTG
TGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGATCTGTCTGCCTGCAATCTACAAGGT
TTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGATTTCGGAGGAATAATAAATTTGATTT
AAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGAATACATTGAAATGCACAGTTGGTCC
TGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACAGTACATTCTCCTATGTGGATCCTGT
AATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAAATTACCTAAACAGTGGGAATTCTAG
ACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTTATACCCCAGCCCAAACCATTTCAAC
TGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTGAAGATCCCATTGTCTATGAAATTCA
TCCAACCAAATCTTTTATTAGTACTTGGTGGAAAGAACCTCTCAACATTGTCAGTTTTCTATTTTGCTTTGCCAGTGGTGGGAGCACAAT
AACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATG
TCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTT
TTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGAT
CTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAA
GAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGA
GTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTC
AATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCG
CTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATC
TGTAGACTACCGAGCTACTTTTCCAGAAGAATCCAAAGGAACAAGAAGGGATTTCAGAAGCTATGATAAACCTTGGCAATTAAATGCAAA
GAAGCCTAAAAAATCAAAAAGTGACCTTGCTGTGTCTAATATTTCTCCACCATCACCGGACTCCAAATCATTGCCAAGGTCAGTAGAGCA
TCCAAAGTGGAACTGGAGGACTAAACCACAAAGCCGTGATTTTGATGAATTGAATCACATCCTTCAGGAGAGCAAGAAGCTGGGGAAAGC
CCTTGAGAATCTCTCTCGAAGTATTGCAATTTCAGATGAACTCGATAAGGAAACAGTGACATTTAATTCTTCTCTTCTGAGGCCCCGTGT
GATTGGAGAATGGATTGGTAGAGAAGAAAATGATGCTGATCCCCTAGCTGCTGAAATGCTACAGCCTCCAATTCCAAGAAGCAAAAATGA
CCAATGGGAAAGTGAAGATAGTGGCTCTAGTCCTGCAGGAAGCTTAAAGATGGAGCCTAAGAACAAAGGATTAAAACAGCAGCAACAGCA
ACATAAGAAACTCCTGGCCGCAATGCTCTCTCAAGATTCTTTTGAGTCCATCCACAGCCCTACCCCATCTGTAACAGAAGAAGATATTGA
TAATGAAGATGATGCAATGGAATTGCTGGAGGATCTTAATGATTTAAGAATGGAGGGAGTAACAACCCTGGTACCTTCTGGGAGCAAATT
TAACCAAGGCCGTCCTACTTACCCTGCTGAGCCTCAGGCCAAGGTCACACTGAACATCTGTTCAAGGTGTGCCAGGCTTCAAGGAGACAA
CCTGGAAGAAAGGACAGAAGAGTCACTACCAATACTCCATTCTCCAGATGAAAAAATCCCAGATTCATTCGATTCCTTGCCTGGGACTGA
AGAAGCACTAATGGAGGAGGGTGACGAATTTGAGAAAGCATCTAAACTAACAGGACCTGGAGAAGCCTCCAGTGGAGTAGGACACTCACT
GAAAAACTACATGGAAGAAGATGAATCCTTAAAGCAATTGCAGGTAGTTCATCAACCATGGATCTTGCCAAGTGACACAGAAAGTGAAGG
AGTGGAAGCAGAACAAGAGAAACGTTCCGCTGATCTTCTTCTTTGCGTTCCATGCTCTTCTTGTCCTACGCTGGTCTACTCTGGTTTGTG
AAACAGAGAGAAGAAGTTGCAAGTGGTCCTTAAAGAAATGCAGTTATTCAAATCCTTATGTATAGTTCTAATTTTATTTACTATGTGTAA
TCATTTAGAGAATGGTTATTTTTATAATCTCAATAATAAACAAGTACTATCGTAGCCAGGGGGTGCCCAAGTATGTAATCAGAGAACACT
AATCCTGGCAAAGGATTGTGGGGTGGTCAGGAGGCCGGCTGCCTTTTGACATGGTTAGAGTCCTGGGTTTAGATTACTTTATAAATAGTT

>In-frame_ENST00000318493_ENST00000518698_TCGA-GL-7773_MET_chr7_116412043_+_C8orf34_chr8_69358563_length(amino acids)=1407AA_start in transcript=187_stop in transcript=4410
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL
TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAM
NKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISTWWKEPLNIVSFLFCFASGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQH
RSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSC
ENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYD
ARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPK
WNWRTKPQSRDFDELNHILQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQW
ESEDSGSSPAGSLKMEPKNKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQ
GRPTYPAEPQAKVTLNICSRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKN

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Fusion Gene PPI Analysis for MET-C8orf34


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMETchr7:116412043chr8:69358563ENST00000318493+14211320_13591027.33333333333331409.0MUC20
HgeneMETchr7:116412043chr8:69358563ENST00000397752+14211320_13591009.33333333333341391.0MUC20
HgeneMETchr7:116412043chr8:69358563ENST00000436117+191320_13590.0765.0MUC20
HgeneMETchr7:116412043chr8:69358564ENST00000318493+14211320_13591027.33333333333331409.0MUC20
HgeneMETchr7:116412043chr8:69358564ENST00000397752+14211320_13591009.33333333333341391.0MUC20
HgeneMETchr7:116412043chr8:69358564ENST00000436117+191320_13590.0765.0MUC20
HgeneMETchr7:116412043chr8:69358563ENST00000318493+14211212_13901027.33333333333331409.0RANBP9
HgeneMETchr7:116412043chr8:69358563ENST00000397752+14211212_13901009.33333333333341391.0RANBP9
HgeneMETchr7:116412043chr8:69358563ENST00000436117+191212_13900.0765.0RANBP9
HgeneMETchr7:116412043chr8:69358564ENST00000318493+14211212_13901027.33333333333331409.0RANBP9
HgeneMETchr7:116412043chr8:69358564ENST00000397752+14211212_13901009.33333333333341391.0RANBP9
HgeneMETchr7:116412043chr8:69358564ENST00000436117+191212_13900.0765.0RANBP9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MET-C8orf34


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MET-C8orf34


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMETC1306837Papillary Renal Cell Carcinoma9CGI;CLINGEN;CTD_human;ORPHANET
HgeneMETC1336078Papillary renal cell carcinoma, sporadic7CLINGEN
HgeneMETC1336839Type 1 Papillary Renal Cell Carcinoma5UNIPROT
HgeneMETC0007131Non-Small Cell Lung Carcinoma4CGI;CTD_human
HgeneMETC1836723Tibia, Bowing of, with Pseudarthrosis and Pectus Excavatum4ORPHANET
HgeneMETC4085248OSTEOFIBROUS DYSPLASIA, SUSCEPTIBILITY TO4ORPHANET
HgeneMETC0001418Adenocarcinoma2CTD_human
HgeneMETC0004352Autistic Disorder2CTD_human
HgeneMETC0024623Malignant neoplasm of stomach2CGI;CTD_human;UNIPROT
HgeneMETC0027627Neoplasm Metastasis2CTD_human
HgeneMETC0038356Stomach Neoplasms2CGI;CTD_human
HgeneMETC0205641Adenocarcinoma, Basal Cell2CTD_human
HgeneMETC0205642Adenocarcinoma, Oxyphilic2CTD_human
HgeneMETC0205643Carcinoma, Cribriform2CTD_human
HgeneMETC0205644Carcinoma, Granular Cell2CTD_human
HgeneMETC0205645Adenocarcinoma, Tubular2CTD_human
HgeneMETC1708349Hereditary Diffuse Gastric Cancer2CTD_human
HgeneMETC0004114Astrocytoma1CTD_human
HgeneMETC0007097Carcinoma1CTD_human
HgeneMETC0007134Renal Cell Carcinoma1CTD_human
HgeneMETC0007137Squamous cell carcinoma1CTD_human
HgeneMETC0009241Cognition Disorders1CTD_human
HgeneMETC0014859Esophageal Neoplasms1CTD_human
HgeneMETC0017636Glioblastoma1CTD_human
HgeneMETC0019189Hepatitis, Chronic1CTD_human
HgeneMETC0019207Hepatoma, Morris1CTD_human
HgeneMETC0019208Hepatoma, Novikoff1CTD_human
HgeneMETC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneMETC0023904Liver Neoplasms, Experimental1CTD_human
HgeneMETC0024121Lung Neoplasms1CTD_human
HgeneMETC0024232Lymphatic Metastasis1CTD_human
HgeneMETC0025202melanoma1CTD_human
HgeneMETC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneMETC0027626Neoplasm Invasiveness1CTD_human
HgeneMETC0027819Neuroblastoma1CTD_human
HgeneMETC0029463Osteosarcoma1CTD_human
HgeneMETC0033578Prostatic Neoplasms1CTD_human
HgeneMETC0036341Schizophrenia1CTD_human
HgeneMETC0037199Sinusitis1CTD_human
HgeneMETC0086404Experimental Hepatoma1CTD_human
HgeneMETC0149519Chronic Persistent Hepatitis1CTD_human
HgeneMETC0205696Anaplastic carcinoma1CTD_human
HgeneMETC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneMETC0205698Undifferentiated carcinoma1CTD_human
HgeneMETC0205699Carcinomatosis1CTD_human
HgeneMETC0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneMETC0242379Malignant neoplasm of lung1CTD_human
HgeneMETC0279606Childhood Hepatocellular Carcinoma1ORPHANET
HgeneMETC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CGI;CTD_human
HgeneMETC0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneMETC0280785Diffuse Astrocytoma1CTD_human
HgeneMETC0334579Anaplastic astrocytoma1CTD_human
HgeneMETC0334580Protoplasmic astrocytoma1CTD_human
HgeneMETC0334581Gemistocytic astrocytoma1CTD_human
HgeneMETC0334582Fibrillary Astrocytoma1CTD_human
HgeneMETC0334583Pilocytic Astrocytoma1CTD_human
HgeneMETC0334588Giant Cell Glioblastoma1CTD_human
HgeneMETC0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneMETC0345967Malignant mesothelioma1CTD_human
HgeneMETC0376358Malignant neoplasm of prostate1CTD_human
HgeneMETC0520463Chronic active hepatitis1CTD_human
HgeneMETC0524611Cryptogenic Chronic Hepatitis1CTD_human
HgeneMETC0546837Malignant neoplasm of esophagus1CTD_human
HgeneMETC0547065Mixed oligoastrocytoma1CTD_human
HgeneMETC0750935Cerebral Astrocytoma1CTD_human
HgeneMETC0750936Intracranial Astrocytoma1CTD_human
HgeneMETC0919267ovarian neoplasm1CTD_human
HgeneMETC1140680Malignant neoplasm of ovary1CTD_human
HgeneMETC1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneMETC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneMETC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneMETC1621958Glioblastoma Multiforme1CTD_human
HgeneMETC1704230Grade I Astrocytoma1CTD_human
HgeneMETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome1CLINGEN
HgeneMETC1876165Copper-Overload Cirrhosis1CTD_human
HgeneMETC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneMETC2239176Liver carcinoma1CGI;CTD_human;UNIPROT
HgeneMETC3711374Nonsyndromic Deafness1CLINGEN
HgeneMETC4084709DEAFNESS, AUTOSOMAL RECESSIVE 971CTD_human;UNIPROT