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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MET-CFTR (FusionGDB2 ID:52690)

Fusion Gene Summary for MET-CFTR

check button Fusion gene summary
Fusion gene informationFusion gene name: MET-CFTR
Fusion gene ID: 52690
HgeneTgene
Gene symbol

MET

CFTR

Gene ID

8731

1080

Gene nameRNA guanine-7 methyltransferaseCF transmembrane conductance regulator
SynonymsCMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMetABC35|ABCC7|CF|CFTR/MRP|MRP7|TNR-CFTR|dJ760C5.1
Cytomap

18p11.21

7q31.2

Type of geneprotein-codingprotein-coding
DescriptionmRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferasecystic fibrosis transmembrane conductance regulatorcAMP-dependent chloride channelchannel conductance-controlling ATPasecystic fibrosis transmembrane conductance regulatingcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-f
Modification date2020032920200329
UniProtAcc.

P13569

Ensembl transtripts involved in fusion geneENST00000397752, ENST00000318493, 
ENST00000436117, ENST00000495962, 
ENST00000539704, 		ENST00000003084, 
ENST00000454343, ENST00000608965, 
Fusion gene scores* DoF score11 X 10 X 9=99013 X 15 X 10=1950
# samples 1613
** MAII scorelog2(16/990*10)=-2.62935662007961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1950*10)=-3.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MET [Title/Abstract] AND CFTR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMET(116340338)-CFTR(117355812), # samples:1
MET(116312631)-CFTR(117355812), # samples:1
MET(116312631)-CFTR(117352395), # samples:1
MET(116340338)-CFTR(117282492), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871

TgeneCFTR

GO:0015701

bicarbonate transport

15010471|19019741

TgeneCFTR

GO:0034976

response to endoplasmic reticulum stress

21884936|28067262

TgeneCFTR

GO:1902476

chloride transmembrane transport

11524016|11707463|19019741

TgeneCFTR

GO:1902943

positive regulation of voltage-gated chloride channel activity

22006324

TgeneCFTR

GO:1904322

cellular response to forskolin

15010471|19621064


check buttonFusion gene breakpoints across MET (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CFTR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-A61CMETchr7

116340338

+CFTRchr7

117355812

+
ChimerDB4LGGTCGA-HT-A61CMETchr7

116312631

+CFTRchr7

117355812

+
ChimerDB4LGGTCGA-HT-A61CMETchr7

116312631

+CFTRchr7

117352395

+
ChimerDB4STADTCGA-D7-8576-01AMETchr7

116340338

+CFTRchr7

117282492

+


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Fusion Gene ORF analysis for MET-CFTR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000397752ENST00000003084METchr7

116340338

+CFTRchr7

117355812

+
5CDS-intronENST00000397752ENST00000454343METchr7

116340338

+CFTRchr7

117355812

+
5CDS-3UTRENST00000397752ENST00000608965METchr7

116340338

+CFTRchr7

117355812

+
5CDS-intronENST00000318493ENST00000003084METchr7

116340338

+CFTRchr7

117355812

+
5CDS-intronENST00000318493ENST00000454343METchr7

116340338

+CFTRchr7

117355812

+
5CDS-3UTRENST00000318493ENST00000608965METchr7

116340338

+CFTRchr7

117355812

+
5CDS-intronENST00000436117ENST00000003084METchr7

116340338

+CFTRchr7

117355812

+
5CDS-intronENST00000436117ENST00000454343METchr7

116340338

+CFTRchr7

117355812

+
5CDS-3UTRENST00000436117ENST00000608965METchr7

116340338

+CFTRchr7

117355812

+
intron-intronENST00000495962ENST00000003084METchr7

116340338

+CFTRchr7

117355812

+
intron-intronENST00000495962ENST00000454343METchr7

116340338

+CFTRchr7

117355812

+
intron-3UTRENST00000495962ENST00000608965METchr7

116340338

+CFTRchr7

117355812

+
intron-intronENST00000539704ENST00000003084METchr7

116340338

+CFTRchr7

117355812

+
intron-intronENST00000539704ENST00000454343METchr7

116340338

+CFTRchr7

117355812

+
intron-3UTRENST00000539704ENST00000608965METchr7

116340338

+CFTRchr7

117355812

+
5UTR-intronENST00000397752ENST00000003084METchr7

116312631

+CFTRchr7

117355812

+
5UTR-intronENST00000397752ENST00000454343METchr7

116312631

+CFTRchr7

117355812

+
5UTR-3UTRENST00000397752ENST00000608965METchr7

116312631

+CFTRchr7

117355812

+
5UTR-intronENST00000318493ENST00000003084METchr7

116312631

+CFTRchr7

117355812

+
5UTR-intronENST00000318493ENST00000454343METchr7

116312631

+CFTRchr7

117355812

+
5UTR-3UTRENST00000318493ENST00000608965METchr7

116312631

+CFTRchr7

117355812

+
intron-intronENST00000436117ENST00000003084METchr7

116312631

+CFTRchr7

117355812

+
intron-intronENST00000436117ENST00000454343METchr7

116312631

+CFTRchr7

117355812

+
intron-3UTRENST00000436117ENST00000608965METchr7

116312631

+CFTRchr7

117355812

+
intron-intronENST00000495962ENST00000003084METchr7

116312631

+CFTRchr7

117355812

+
intron-intronENST00000495962ENST00000454343METchr7

116312631

+CFTRchr7

117355812

+
intron-3UTRENST00000495962ENST00000608965METchr7

116312631

+CFTRchr7

117355812

+
intron-intronENST00000539704ENST00000003084METchr7

116312631

+CFTRchr7

117355812

+
intron-intronENST00000539704ENST00000454343METchr7

116312631

+CFTRchr7

117355812

+
intron-3UTRENST00000539704ENST00000608965METchr7

116312631

+CFTRchr7

117355812

+
5UTR-intronENST00000397752ENST00000003084METchr7

116312631

+CFTRchr7

117352395

+
5UTR-intronENST00000397752ENST00000454343METchr7

116312631

+CFTRchr7

117352395

+
5UTR-intronENST00000397752ENST00000608965METchr7

116312631

+CFTRchr7

117352395

+
5UTR-intronENST00000318493ENST00000003084METchr7

116312631

+CFTRchr7

117352395

+
5UTR-intronENST00000318493ENST00000454343METchr7

116312631

+CFTRchr7

117352395

+
5UTR-intronENST00000318493ENST00000608965METchr7

116312631

+CFTRchr7

117352395

+
intron-intronENST00000436117ENST00000003084METchr7

116312631

+CFTRchr7

117352395

+
intron-intronENST00000436117ENST00000454343METchr7

116312631

+CFTRchr7

117352395

+
intron-intronENST00000436117ENST00000608965METchr7

116312631

+CFTRchr7

117352395

+
intron-intronENST00000495962ENST00000003084METchr7

116312631

+CFTRchr7

117352395

+
intron-intronENST00000495962ENST00000454343METchr7

116312631

+CFTRchr7

117352395

+
intron-intronENST00000495962ENST00000608965METchr7

116312631

+CFTRchr7

117352395

+
intron-intronENST00000539704ENST00000003084METchr7

116312631

+CFTRchr7

117352395

+
intron-intronENST00000539704ENST00000454343METchr7

116312631

+CFTRchr7

117352395

+
intron-intronENST00000539704ENST00000608965METchr7

116312631

+CFTRchr7

117352395

+
In-frameENST00000397752ENST00000003084METchr7

116340338

+CFTRchr7

117282492

+
In-frameENST00000397752ENST00000454343METchr7

116340338

+CFTRchr7

117282492

+
5CDS-intronENST00000397752ENST00000608965METchr7

116340338

+CFTRchr7

117282492

+
In-frameENST00000318493ENST00000003084METchr7

116340338

+CFTRchr7

117282492

+
In-frameENST00000318493ENST00000454343METchr7

116340338

+CFTRchr7

117282492

+
5CDS-intronENST00000318493ENST00000608965METchr7

116340338

+CFTRchr7

117282492

+
In-frameENST00000436117ENST00000003084METchr7

116340338

+CFTRchr7

117282492

+
In-frameENST00000436117ENST00000454343METchr7

116340338

+CFTRchr7

117282492

+
5CDS-intronENST00000436117ENST00000608965METchr7

116340338

+CFTRchr7

117282492

+
intron-3CDSENST00000495962ENST00000003084METchr7

116340338

+CFTRchr7

117282492

+
intron-3CDSENST00000495962ENST00000454343METchr7

116340338

+CFTRchr7

117282492

+
intron-intronENST00000495962ENST00000608965METchr7

116340338

+CFTRchr7

117282492

+
intron-3CDSENST00000539704ENST00000003084METchr7

116340338

+CFTRchr7

117282492

+
intron-3CDSENST00000539704ENST00000454343METchr7

116340338

+CFTRchr7

117282492

+
intron-intronENST00000539704ENST00000608965METchr7

116340338

+CFTRchr7

117282492

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397752METchr7116340338+ENST00000003084CFTRchr7117282492+367914002002125641
ENST00000397752METchr7116340338+ENST00000454343CFTRchr7117282492+368314002002125641
ENST00000318493METchr7116340338+ENST00000003084CFTRchr7117282492+366613871872112641
ENST00000318493METchr7116340338+ENST00000454343CFTRchr7117282492+367013871872112641
ENST00000436117METchr7116340338+ENST00000003084CFTRchr7117282492+3479120001925641
ENST00000436117METchr7116340338+ENST00000454343CFTRchr7117282492+3483120001925641

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397752ENST00000003084METchr7116340338+CFTRchr7117282492+0.000375380.9996246
ENST00000397752ENST00000454343METchr7116340338+CFTRchr7117282492+0.0003710270.9996289
ENST00000318493ENST00000003084METchr7116340338+CFTRchr7117282492+0.0003779180.9996221
ENST00000318493ENST00000454343METchr7116340338+CFTRchr7117282492+0.0003735170.9996265
ENST00000436117ENST00000003084METchr7116340338+CFTRchr7117282492+0.0003630540.9996369
ENST00000436117ENST00000454343METchr7116340338+CFTRchr7117282492+0.0003572330.9996427

Top

Fusion Genomic Features for MET-CFTR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MET-CFTR


check button Go to

FGviewer for the breakpoints of chr7:116340338-chr7:117282492

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CFTR

P13569

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17434346, PubMed:27941075, PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCFTRchr7:116340338chr7:117282492ENST0000045434320261210_14431178.01420.0DomainABC transporter 2
TgeneCFTRchr7:116340338chr7:117282492ENST0000000308421271244_12511239.01481.0Nucleotide bindingATP 2
TgeneCFTRchr7:116340338chr7:117282492ENST0000045434320261244_12511178.01420.0Nucleotide bindingATP 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMETchr7:116340338chr7:117282492ENST00000318493+2211078_1345400.01409.0DomainProtein kinase
HgeneMETchr7:116340338chr7:117282492ENST00000318493+22127_515400.01409.0DomainSema
HgeneMETchr7:116340338chr7:117282492ENST00000318493+221563_655400.01409.0DomainNote=IPT/TIG 1
HgeneMETchr7:116340338chr7:117282492ENST00000318493+221657_739400.01409.0DomainNote=IPT/TIG 2
HgeneMETchr7:116340338chr7:117282492ENST00000318493+221742_836400.01409.0DomainNote=IPT/TIG 3
HgeneMETchr7:116340338chr7:117282492ENST00000397752+2211078_1345400.01391.0DomainProtein kinase
HgeneMETchr7:116340338chr7:117282492ENST00000397752+22127_515400.01391.0DomainSema
HgeneMETchr7:116340338chr7:117282492ENST00000397752+221563_655400.01391.0DomainNote=IPT/TIG 1
HgeneMETchr7:116340338chr7:117282492ENST00000397752+221657_739400.01391.0DomainNote=IPT/TIG 2
HgeneMETchr7:116340338chr7:117282492ENST00000397752+221742_836400.01391.0DomainNote=IPT/TIG 3
HgeneMETchr7:116340338chr7:117282492ENST00000436117+191078_1345400.0765.0DomainProtein kinase
HgeneMETchr7:116340338chr7:117282492ENST00000436117+1927_515400.0765.0DomainSema
HgeneMETchr7:116340338chr7:117282492ENST00000436117+19563_655400.0765.0DomainNote=IPT/TIG 1
HgeneMETchr7:116340338chr7:117282492ENST00000436117+19657_739400.0765.0DomainNote=IPT/TIG 2
HgeneMETchr7:116340338chr7:117282492ENST00000436117+19742_836400.0765.0DomainNote=IPT/TIG 3
HgeneMETchr7:116340338chr7:117282492ENST00000318493+2211084_1092400.01409.0Nucleotide bindingATP
HgeneMETchr7:116340338chr7:117282492ENST00000397752+2211084_1092400.01391.0Nucleotide bindingATP
HgeneMETchr7:116340338chr7:117282492ENST00000436117+191084_1092400.0765.0Nucleotide bindingATP
HgeneMETchr7:116340338chr7:117282492ENST00000318493+22125_932400.01409.0Topological domainExtracellular
HgeneMETchr7:116340338chr7:117282492ENST00000318493+221956_1390400.01409.0Topological domainCytoplasmic
HgeneMETchr7:116340338chr7:117282492ENST00000397752+22125_932400.01391.0Topological domainExtracellular
HgeneMETchr7:116340338chr7:117282492ENST00000397752+221956_1390400.01391.0Topological domainCytoplasmic
HgeneMETchr7:116340338chr7:117282492ENST00000436117+1925_932400.0765.0Topological domainExtracellular
HgeneMETchr7:116340338chr7:117282492ENST00000436117+19956_1390400.0765.0Topological domainCytoplasmic
HgeneMETchr7:116340338chr7:117282492ENST00000318493+221933_955400.01409.0TransmembraneHelical
HgeneMETchr7:116340338chr7:117282492ENST00000397752+221933_955400.01391.0TransmembraneHelical
HgeneMETchr7:116340338chr7:117282492ENST00000436117+19933_955400.0765.0TransmembraneHelical
TgeneCFTRchr7:116340338chr7:117282492ENST0000000308421271210_14431239.01481.0DomainABC transporter 2
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127423_6461239.01481.0DomainABC transporter 1
TgeneCFTRchr7:116340338chr7:117282492ENST00000003084212781_3651239.01481.0DomainABC transmembrane type-1 1
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127859_11551239.01481.0DomainABC transmembrane type-1 2
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026423_6461178.01420.0DomainABC transporter 1
TgeneCFTRchr7:116340338chr7:117282492ENST00000454343202681_3651178.01420.0DomainABC transmembrane type-1 1
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026859_11551178.01420.0DomainABC transmembrane type-1 2
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127458_4651239.01481.0Nucleotide bindingATP 1
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026458_4651178.01420.0Nucleotide bindingATP 1
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127654_8311239.01481.0RegionIntrinsically disordered R region
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026654_8311178.01420.0RegionIntrinsically disordered R region
TgeneCFTRchr7:116340338chr7:117282492ENST0000000308421271012_10131239.01481.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST0000000308421271035_10951239.01481.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST0000000308421271117_11301239.01481.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST0000000308421271152_14801239.01481.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127147_1951239.01481.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST0000000308421271_771239.01481.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127217_2221239.01481.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127244_2981239.01481.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127320_3391239.01481.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127359_8581239.01481.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127880_9181239.01481.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127940_9901239.01481.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST00000003084212799_1221239.01481.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST0000045434320261012_10131178.01420.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST0000045434320261035_10951178.01420.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST0000045434320261117_11301178.01420.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST0000045434320261152_14801178.01420.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026147_1951178.01420.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST0000045434320261_771178.01420.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026217_2221178.01420.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026244_2981178.01420.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026320_3391178.01420.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026359_8581178.01420.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026880_9181178.01420.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026940_9901178.01420.0Topological domainCytoplasmic
TgeneCFTRchr7:116340338chr7:117282492ENST00000454343202699_1221178.01420.0Topological domainExtracellular
TgeneCFTRchr7:116340338chr7:117282492ENST0000000308421271014_10341239.01481.0TransmembraneHelical%3B Name%3D10
TgeneCFTRchr7:116340338chr7:117282492ENST0000000308421271096_11161239.01481.0TransmembraneHelical%3B Name%3D11
TgeneCFTRchr7:116340338chr7:117282492ENST0000000308421271131_11511239.01481.0TransmembraneHelical%3B Name%3D12
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127123_1461239.01481.0TransmembraneHelical%3B Name%3D2
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127196_2161239.01481.0TransmembraneHelical%3B Name%3D3
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127223_2431239.01481.0TransmembraneHelical%3B Name%3D4
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127299_3191239.01481.0TransmembraneHelical%3B Name%3D5
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127340_3581239.01481.0TransmembraneHelical%3B Name%3D6
TgeneCFTRchr7:116340338chr7:117282492ENST00000003084212778_981239.01481.0TransmembraneHelical%3B Name%3D1
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127859_8791239.01481.0TransmembraneHelical%3B Name%3D7
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127919_9391239.01481.0TransmembraneDiscontinuously helical%3B Name%3D8
TgeneCFTRchr7:116340338chr7:117282492ENST000000030842127991_10111239.01481.0TransmembraneHelical%3B Name%3D9
TgeneCFTRchr7:116340338chr7:117282492ENST0000045434320261014_10341178.01420.0TransmembraneHelical%3B Name%3D10
TgeneCFTRchr7:116340338chr7:117282492ENST0000045434320261096_11161178.01420.0TransmembraneHelical%3B Name%3D11
TgeneCFTRchr7:116340338chr7:117282492ENST0000045434320261131_11511178.01420.0TransmembraneHelical%3B Name%3D12
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026123_1461178.01420.0TransmembraneHelical%3B Name%3D2
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026196_2161178.01420.0TransmembraneHelical%3B Name%3D3
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026223_2431178.01420.0TransmembraneHelical%3B Name%3D4
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026299_3191178.01420.0TransmembraneHelical%3B Name%3D5
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026340_3581178.01420.0TransmembraneHelical%3B Name%3D6
TgeneCFTRchr7:116340338chr7:117282492ENST00000454343202678_981178.01420.0TransmembraneHelical%3B Name%3D1
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026859_8791178.01420.0TransmembraneHelical%3B Name%3D7
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026919_9391178.01420.0TransmembraneDiscontinuously helical%3B Name%3D8
TgeneCFTRchr7:116340338chr7:117282492ENST000004543432026991_10111178.01420.0TransmembraneHelical%3B Name%3D9


Top

Fusion Gene Sequence for MET-CFTR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000397752_ENST00000003084_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(transcript)=3679nt_BP=1400nt
AGGTGACCCGGAGGCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGG
GCGACAGCTGACTTGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCAC
CGAAAGATAAACCTCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATG
GGGAGTGTAAAGAGGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGA
ATGTCATTCTACATGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGT
ACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAG
ATAACATCAACATGGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGAC
ATGTCTTTCCCCACAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTG
ACTGTGTGGTGAGCGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTT
CTTATTTCCCAGATCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCT
ACATTGATGTTTTACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGG
TCCAAAGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAA
TGCCTCTGGAGTGTATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCA
AGCCTGGGGCCCAGCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTG
CCGAACCAATGGATCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGA
GATGTCTCCAGCATTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTT
TGTTATCAGCTTTTTTGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGA
GGAAAGCCTTTGGAGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATC
AAGAAATATGGAAAGTTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGG
GCTGTGTCCTAAGCCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCA
GTGCTCATTTGGATCCAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACA
GGATAGAAGCAATGCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACG
AGAGGAGCCTCTTCCGGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCC
AGATTGCTGCTCTGAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCT
CATGGAATTGGAGCTCGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAG
TTTTTTTTTAAAAAAGAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGT
GTGAAAGGTACTTCAAATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGG
AAAGGCAGCTCTAAATGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAAT
CATACTTCTTAGGGTTATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCAT
GATGTTTAGAAACACAACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGAC
TGCACATCAAAATATGCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAG
GTCTACCAAAAATCTCAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGG
TTCCCTTGATGAAGAAGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGT
ATGTTAGTGCAAATTGTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGG
GTAGACACACATGAAGTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACAC
TAAGAGAGAATGAGAGACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTT
TCTCTAGGAAATATTTATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAA
ATAATTTTTATATTTGAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGG
TGATATTAACCAGGGGCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCA
GCCAGCACAGCCTCTTAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCA

>In-frame_ENST00000397752_ENST00000003084_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(amino acids)=641AA_start in transcript=200_stop in transcript=2125
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI
PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV
TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE

--------------------------------------------------------------
>In-frame_ENST00000397752_ENST00000454343_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(transcript)=3683nt_BP=1400nt
AGGTGACCCGGAGGCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGG
GCGACAGCTGACTTGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCAC
CGAAAGATAAACCTCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATG
GGGAGTGTAAAGAGGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGA
ATGTCATTCTACATGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGT
ACAAGACTGGGCCTGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAG
ATAACATCAACATGGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGAC
ATGTCTTTCCCCACAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTG
ACTGTGTGGTGAGCGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTT
CTTATTTCCCAGATCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCT
ACATTGATGTTTTACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGG
TCCAAAGGGAAACTCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAA
TGCCTCTGGAGTGTATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCA
AGCCTGGGGCCCAGCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTG
CCGAACCAATGGATCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGA
GATGTCTCCAGCATTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTT
TGTTATCAGCTTTTTTGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGA
GGAAAGCCTTTGGAGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATC
AAGAAATATGGAAAGTTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGG
GCTGTGTCCTAAGCCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCA
GTGCTCATTTGGATCCAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACA
GGATAGAAGCAATGCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACG
AGAGGAGCCTCTTCCGGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCC
AGATTGCTGCTCTGAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCT
CATGGAATTGGAGCTCGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAG
TTTTTTTTTAAAAAAGAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGT
GTGAAAGGTACTTCAAATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGG
AAAGGCAGCTCTAAATGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAAT
CATACTTCTTAGGGTTATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCAT
GATGTTTAGAAACACAACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGAC
TGCACATCAAAATATGCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAG
GTCTACCAAAAATCTCAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGG
TTCCCTTGATGAAGAAGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGT
ATGTTAGTGCAAATTGTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGG
GTAGACACACATGAAGTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACAC
TAAGAGAGAATGAGAGACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTT
TCTCTAGGAAATATTTATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAA
ATAATTTTTATATTTGAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGG
TGATATTAACCAGGGGCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCA
GCCAGCACAGCCTCTTAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCA

>In-frame_ENST00000397752_ENST00000454343_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(amino acids)=641AA_start in transcript=200_stop in transcript=2125
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI
PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV
TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE

--------------------------------------------------------------
>In-frame_ENST00000318493_ENST00000003084_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(transcript)=3666nt_BP=1387nt
GCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGGGCGACAGCTGACT
TGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCACCGAAAGATAAACC
TCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGA
GGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACA
TGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCC
TGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACAT
GGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCA
CAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAG
CGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGA
TCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTT
ACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAAC
TCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTG
TATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCA
GCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGA
TCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCA
TTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTT
TTTGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGAGGAAAGCCTTTGG
AGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAA
AGTTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGGGCTGTGTCCTAAG
CCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGA
TCCAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACAGGATAGAAGCAAT
GCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTT
CCGGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCCAGATTGCTGCTCT
GAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCTCATGGAATTGGAG
CTCGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAGTTTTTTTTTAAAA
AAGAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGTGTGAAAGGTACTT
CAAATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGGAAAGGCAGCTCTA
AATGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAATCATACTTCTTAGG
GTTATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCATGATGTTTAGAAAC
ACAACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGACTGCACATCAAAAT
ATGCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAGGTCTACCAAAAAT
CTCAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGGTTCCCTTGATGAA
GAAGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGTATGTTAGTGCAAA
TTGTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGGGTAGACACACATG
AAGTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACACTAAGAGAGAATGA
GAGACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTTTCTCTAGGAAATA
TTTATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAAATAATTTTTATAT
TTGAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGGTGATATTAACCAG
GGGCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCAGCCAGCACAGCCT
CTTAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCAAACTGACTCTTAA

>In-frame_ENST00000318493_ENST00000003084_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(amino acids)=641AA_start in transcript=187_stop in transcript=2112
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI
PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV
TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE

--------------------------------------------------------------
>In-frame_ENST00000318493_ENST00000454343_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(transcript)=3670nt_BP=1387nt
GCCCTCGCCGCCCGCGGCGCCCCGAGCGCTTTGTGAGCAGATGCGGAGCCGAGTGGAGGGCGCGAGCCAGATGCGGGGCGACAGCTGACT
TGCTGAGAGGAGGCGGGGAGGCGCGGAGCGCGCGTGTGGTCCTTGCGCCGCTGACTTCTCCACTGGTTCCTGGGCACCGAAAGATAAACC
TCTCATAATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGA
GGCACTAGCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACA
TGAGCATCACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCC
TGTGCTGGAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACAT
GGCTCTAGTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCA
CAATCATACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAG
CGCCCTGGGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGA
TCATCCATTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTT
ACCTGAGTTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAAC
TCTAGATGCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTG
TATTCTCACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCA
GCTTGCTAGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGA
TCGATCTGCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCA
TTTTTACGGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTT
TTTGAGACTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGAGGAAAGCCTTTGG
AGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAA
AGTTGCAGATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGGGCTGTGTCCTAAG
CCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGA
TCCAGTAACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACAGGATAGAAGCAAT
GCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTT
CCGGCAAGCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCCAGATTGCTGCTCT
GAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCTCATGGAATTGGAG
CTCGTGGGACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAGTTTTTTTTTAAAA
AAGAAACATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGTGTGAAAGGTACTT
CAAATCCTTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGGAAAGGCAGCTCTA
AATGTCAATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAATCATACTTCTTAGG
GTTATGATTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCATGATGTTTAGAAAC
ACAACTATATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGACTGCACATCAAAAT
ATGCCCCATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAGGTCTACCAAAAAT
CTCAATATTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGGTTCCCTTGATGAA
GAAGTTGATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGTATGTTAGTGCAAA
TTGTCACAGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGGGTAGACACACATG
AAGTCCAAGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACACTAAGAGAGAATGA
GAGACACACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTTTCTCTAGGAAATA
TTTATTTTAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAAATAATTTTTATAT
TTGAAATATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGGTGATATTAACCAG
GGGCCATGAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCAGCCAGCACAGCCT
CTTAGATGCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCAAACTGACTCTTAA

>In-frame_ENST00000318493_ENST00000454343_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(amino acids)=641AA_start in transcript=187_stop in transcript=2112
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI
PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV
TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE

--------------------------------------------------------------
>In-frame_ENST00000436117_ENST00000003084_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(transcript)=3479nt_BP=1200nt
ATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGAGGCACTA
GCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACATGAGCAT
CACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCCTGTGCTG
GAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACATGGCTCTA
GTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCACAATCAT
ACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAGCGCCCTG
GGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGATCATCCA
TTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTTACCTGAG
TTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAACTCTAGAT
GCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTGTATTCTC
ACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCAGCTTGCT
AGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGATCGATCT
GCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCATTTTTAC
GGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTTTTTGAGA
CTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGAGGAAAGCCTTTGGAGTGATA
CCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAAAGTTGCA
GATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGGGCTGTGTCCTAAGCCATGGC
CACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGATCCAGTA
ACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACAGGATAGAAGCAATGCTGGAA
TGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTTCCGGCAA
GCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCCAGATTGCTGCTCTGAAAGAG
GAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCTCATGGAATTGGAGCTCGTGG
GACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAGTTTTTTTTTAAAAAAGAAAC
ATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGTGTGAAAGGTACTTCAAATCC
TTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGGAAAGGCAGCTCTAAATGTCA
ATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAATCATACTTCTTAGGGTTATGA
TTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCATGATGTTTAGAAACACAACTA
TATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGACTGCACATCAAAATATGCCCC
ATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAGGTCTACCAAAAATCTCAATA
TTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGGTTCCCTTGATGAAGAAGTTG
ATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGTATGTTAGTGCAAATTGTCAC
AGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGGGTAGACACACATGAAGTCCA
AGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACACTAAGAGAGAATGAGAGACAC
ACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTTTCTCTAGGAAATATTTATTT
TAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAAATAATTTTTATATTTGAAAT
ATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGGTGATATTAACCAGGGGCCAT
GAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCAGCCAGCACAGCCTCTTAGAT
GCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCAAACTGACTCTTAAGAAGACT

>In-frame_ENST00000436117_ENST00000003084_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(amino acids)=641AA_start in transcript=0_stop in transcript=1925
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI
PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV
TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE

--------------------------------------------------------------
>In-frame_ENST00000436117_ENST00000454343_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(transcript)=3483nt_BP=1200nt
ATGAAGGCCCCCGCTGTGCTTGCACCTGGCATCCTCGTGCTCCTGTTTACCTTGGTGCAGAGGAGCAATGGGGAGTGTAAAGAGGCACTA
GCAAAGTCCGAGATGAATGTGAATATGAAGTATCAGCTTCCCAACTTCACCGCGGAAACACCCATCCAGAATGTCATTCTACATGAGCAT
CACATTTTCCTTGGTGCCACTAACTACATTTATGTTTTAAATGAGGAAGACCTTCAGAAGGTTGCTGAGTACAAGACTGGGCCTGTGCTG
GAACACCCAGATTGTTTCCCATGTCAGGACTGCAGCAGCAAAGCCAATTTATCAGGAGGTGTTTGGAAAGATAACATCAACATGGCTCTA
GTTGTCGACACCTACTATGATGATCAACTCATTAGCTGTGGCAGCGTCAACAGAGGGACCTGCCAGCGACATGTCTTTCCCCACAATCAT
ACTGCTGACATACAGTCGGAGGTTCACTGCATATTCTCCCCACAGATAGAAGAGCCCAGCCAGTGTCCTGACTGTGTGGTGAGCGCCCTG
GGAGCCAAAGTCCTTTCATCTGTAAAGGACCGGTTCATCAACTTCTTTGTAGGCAATACCATAAATTCTTCTTATTTCCCAGATCATCCA
TTGCATTCGATATCAGTGAGAAGGCTAAAGGAAACGAAAGATGGTTTTATGTTTTTGACGGACCAGTCCTACATTGATGTTTTACCTGAG
TTCAGAGATTCTTACCCCATTAAGTATGTCCATGCCTTTGAAAGCAACAATTTTATTTACTTCTTGACGGTCCAAAGGGAAACTCTAGAT
GCTCAGACTTTTCACACAAGAATAATCAGGTTCTGTTCCATAAACTCTGGATTGCATTCCTACATGGAAATGCCTCTGGAGTGTATTCTC
ACAGAAAAGAGAAAAAAGAGATCCACAAAGAAGGAAGTGTTTAATATACTTCAGGCTGCGTATGTCAGCAAGCCTGGGGCCCAGCTTGCT
AGACAAATAGGAGCCAGCCTGAATGATGACATTCTTTTCGGGGTGTTCGCACAAAGCAAGCCAGATTCTGCCGAACCAATGGATCGATCT
GCCATGTGTGCATTCCCTATCAAATATGTCAACGACTTCTTCAACAAGATCGTCAACAAAAACAATGTGAGATGTCTCCAGCATTTTTAC
GGACCCAATCATGAGCACTGCTTTAATAGGGTGGGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTTTTTGAGA
CTACTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAACAGTGGAGGAAAGCCTTTGGAGTGATA
CCACAGAAAGTATTTATTTTTTCTGGAACATTTAGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAAAGTTGCA
GATGAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTGGATGGGGGCTGTGTCCTAAGCCATGGC
CACAAGCAGTTGATGTGCTTGGCTAGATCTGTTCTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGATCCAGTA
ACATACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGTGAACACAGGATAGAAGCAATGCTGGAA
TGCCAACAATTTTTGGTCATAGAAGAGAACAAAGTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTTCCGGCAA
GCCATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCTAAGCCCCAGATTGCTGCTCTGAAAGAG
GAGACAGAAGAAGAGGTGCAAGATACAAGGCTTTAGAGAGCAGCATAAATGTTGACATGGGACATTTGCTCATGGAATTGGAGCTCGTGG
GACAGTCACCTCATGGAATTGGAGCTCGTGGAACAGTTACCTCTGCCTCAGAAAACAAGGATGAATTAAGTTTTTTTTTAAAAAAGAAAC
ATTTGGTAAGGGGAATTGAGGACACTGATATGGGTCTTGATAAATGGCTTCCTGGCAATAGTCAAATTGTGTGAAAGGTACTTCAAATCC
TTGAAGATTTACCACTTGTGTTTTGCAAGCCAGATTTTCCTGAAAACCCTTGCCATGTGCTAGTAATTGGAAAGGCAGCTCTAAATGTCA
ATCAGCCTAGTTGATCAGCTTATTGTCTAGTGAAACTCGTTAATTTGTAGTGTTGGAGAAGAACTGAAATCATACTTCTTAGGGTTATGA
TTAAGTAATGATAACTGGAAACTTCAGCGGTTTATATAAGCTTGTATTCCTTTTTCTCTCCTCTCCCCATGATGTTTAGAAACACAACTA
TATTGTTTGCTAAGCATTCCAACTATCTCATTTCCAAGCAAGTATTAGAATACCACAGGAACCACAAGACTGCACATCAAAATATGCCCC
ATTCAACATCTAGTGAGCAGTCAGGAAAGAGAACTTCCAGATCCTGGAAATCAGGGTTAGTATTGTCCAGGTCTACCAAAAATCTCAATA
TTTCAGATAATCACAATACATCCCTTACCTGGGAAAGGGCTGTTATAATCTTTCACAGGGGACAGGATGGTTCCCTTGATGAAGAAGTTG
ATATGCCTTTTCCCAACTCCAGAAAGTGACAAGCTCACAGACCTTTGAACTAGAGTTTAGCTGGAAAAGTATGTTAGTGCAAATTGTCAC
AGGACAGCCCTTCTTTCCACAGAAGCTCCAGGTAGAGGGTGTGTAAGTAGATAGGCCATGGGCACTGTGGGTAGACACACATGAAGTCCA
AGCATTTAGATGTATAGGTTGATGGTGGTATGTTTTCAGGCTAGATGTATGTACTTCATGCTGTCTACACTAAGAGAGAATGAGAGACAC
ACTGAAGAAGCACCAATCATGAATTAGTTTTATATGCTTCTGTTTTATAATTTTGTGAAGCAAAATTTTTTCTCTAGGAAATATTTATTT
TAATAATGTTTCAAACATATATAACAATGCTGTATTTTAAAAGAATGATTATGAATTACATTTGTATAAAATAATTTTTATATTTGAAAT
ATTGACTTTTTATGGCACTAGTATTTCTATGAAATATTATGTTAAAACTGGGACAGGGGAGAACCTAGGGTGATATTAACCAGGGGCCAT
GAATCACCTTTTGGTCTGGAGGGAAGCCTTGGGGCTGATGCAGTTGTTGCCCACAGCTGTATGATTCCCAGCCAGCACAGCCTCTTAGAT
GCAGTTCTGAAGAAGATGGTACCACCAGTCTGACTGTTTCCATCAAGGGTACACTGCCTTCTCAACTCCAAACTGACTCTTAAGAAGACT

>In-frame_ENST00000436117_ENST00000454343_TCGA-D7-8576-01A_MET_chr7_116340338_+_CFTR_chr7_117282492_length(amino acids)=641AA_start in transcript=0_stop in transcript=1925
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVL
EHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLD
AQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVI
PQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV
TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MET-CFTR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCFTRchr7:116340338chr7:117282492ENST0000000308421271386_14801239.01481.0GORASP2
TgeneCFTRchr7:116340338chr7:117282492ENST0000045434320261386_14801178.01420.0GORASP2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMETchr7:116340338chr7:117282492ENST00000318493+2211320_1359400.01409.0MUC20
HgeneMETchr7:116340338chr7:117282492ENST00000397752+2211320_1359400.01391.0MUC20
HgeneMETchr7:116340338chr7:117282492ENST00000436117+191320_1359400.0765.0MUC20
HgeneMETchr7:116340338chr7:117282492ENST00000318493+2211212_1390400.01409.0RANBP9
HgeneMETchr7:116340338chr7:117282492ENST00000397752+2211212_1390400.01391.0RANBP9
HgeneMETchr7:116340338chr7:117282492ENST00000436117+191212_1390400.0765.0RANBP9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MET-CFTR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCFTRP13569DB00887BumetanideAntagonistSmall moleculeApproved
TgeneCFTRP13569DB00887BumetanideAntagonistSmall moleculeApproved
TgeneCFTRP13569DB01016GlyburideAntagonistSmall moleculeApproved
TgeneCFTRP13569DB01016GlyburideAntagonistSmall moleculeApproved
TgeneCFTRP13569DB01050IbuprofenInhibitorSmall moleculeApproved
TgeneCFTRP13569DB01050IbuprofenInhibitorSmall moleculeApproved
TgeneCFTRP13569DB04941CrofelemerAntagonistSmall moleculeApproved
TgeneCFTRP13569DB04941CrofelemerAntagonistSmall moleculeApproved
TgeneCFTRP13569DB08820IvacaftorPotentiatorSmall moleculeApproved
TgeneCFTRP13569DB08820IvacaftorPotentiatorSmall moleculeApproved
TgeneCFTRP13569DB09280LumacaftorModulatorSmall moleculeApproved
TgeneCFTRP13569DB09280LumacaftorModulatorSmall moleculeApproved
TgeneCFTRP13569DB09213DexibuprofenInhibitorSmall moleculeApproved|Investigational
TgeneCFTRP13569DB09213DexibuprofenInhibitorSmall moleculeApproved|Investigational
TgeneCFTRP13569DB11712TezacaftorActivatorSmall moleculeApproved|Investigational
TgeneCFTRP13569DB11712TezacaftorActivatorSmall moleculeApproved|Investigational
TgeneCFTRP13569DB15444ElexacaftorModulatorSmall moleculeApproved|Investigational
TgeneCFTRP13569DB15444ElexacaftorModulatorSmall moleculeApproved|Investigational

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Related Diseases for MET-CFTR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMETC1306837Papillary Renal Cell Carcinoma9CGI;CLINGEN;CTD_human;ORPHANET
HgeneMETC1336078Papillary renal cell carcinoma, sporadic7CLINGEN
HgeneMETC1336839Type 1 Papillary Renal Cell Carcinoma5UNIPROT
HgeneMETC0007131Non-Small Cell Lung Carcinoma4CGI;CTD_human
HgeneMETC1836723Tibia, Bowing of, with Pseudarthrosis and Pectus Excavatum4ORPHANET
HgeneMETC4085248OSTEOFIBROUS DYSPLASIA, SUSCEPTIBILITY TO4ORPHANET
HgeneMETC0001418Adenocarcinoma2CTD_human
HgeneMETC0004352Autistic Disorder2CTD_human
HgeneMETC0024623Malignant neoplasm of stomach2CGI;CTD_human;UNIPROT
HgeneMETC0027627Neoplasm Metastasis2CTD_human
HgeneMETC0038356Stomach Neoplasms2CGI;CTD_human
HgeneMETC0205641Adenocarcinoma, Basal Cell2CTD_human
HgeneMETC0205642Adenocarcinoma, Oxyphilic2CTD_human
HgeneMETC0205643Carcinoma, Cribriform2CTD_human
HgeneMETC0205644Carcinoma, Granular Cell2CTD_human
HgeneMETC0205645Adenocarcinoma, Tubular2CTD_human
HgeneMETC1708349Hereditary Diffuse Gastric Cancer2CTD_human
HgeneMETC0004114Astrocytoma1CTD_human
HgeneMETC0007097Carcinoma1CTD_human
HgeneMETC0007134Renal Cell Carcinoma1CTD_human
HgeneMETC0007137Squamous cell carcinoma1CTD_human
HgeneMETC0009241Cognition Disorders1CTD_human
HgeneMETC0014859Esophageal Neoplasms1CTD_human
HgeneMETC0017636Glioblastoma1CTD_human
HgeneMETC0019189Hepatitis, Chronic1CTD_human
HgeneMETC0019207Hepatoma, Morris1CTD_human
HgeneMETC0019208Hepatoma, Novikoff1CTD_human
HgeneMETC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneMETC0023904Liver Neoplasms, Experimental1CTD_human
HgeneMETC0024121Lung Neoplasms1CTD_human
HgeneMETC0024232Lymphatic Metastasis1CTD_human
HgeneMETC0025202melanoma1CTD_human
HgeneMETC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneMETC0027626Neoplasm Invasiveness1CTD_human
HgeneMETC0027819Neuroblastoma1CTD_human
HgeneMETC0029463Osteosarcoma1CTD_human
HgeneMETC0033578Prostatic Neoplasms1CTD_human
HgeneMETC0036341Schizophrenia1CTD_human
HgeneMETC0037199Sinusitis1CTD_human
HgeneMETC0086404Experimental Hepatoma1CTD_human
HgeneMETC0149519Chronic Persistent Hepatitis1CTD_human
HgeneMETC0205696Anaplastic carcinoma1CTD_human
HgeneMETC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneMETC0205698Undifferentiated carcinoma1CTD_human
HgeneMETC0205699Carcinomatosis1CTD_human
HgeneMETC0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneMETC0242379Malignant neoplasm of lung1CTD_human
HgeneMETC0279606Childhood Hepatocellular Carcinoma1ORPHANET
HgeneMETC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CGI;CTD_human
HgeneMETC0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneMETC0280785Diffuse Astrocytoma1CTD_human
HgeneMETC0334579Anaplastic astrocytoma1CTD_human
HgeneMETC0334580Protoplasmic astrocytoma1CTD_human
HgeneMETC0334581Gemistocytic astrocytoma1CTD_human
HgeneMETC0334582Fibrillary Astrocytoma1CTD_human
HgeneMETC0334583Pilocytic Astrocytoma1CTD_human
HgeneMETC0334588Giant Cell Glioblastoma1CTD_human
HgeneMETC0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneMETC0345967Malignant mesothelioma1CTD_human
HgeneMETC0376358Malignant neoplasm of prostate1CTD_human
HgeneMETC0520463Chronic active hepatitis1CTD_human
HgeneMETC0524611Cryptogenic Chronic Hepatitis1CTD_human
HgeneMETC0546837Malignant neoplasm of esophagus1CTD_human
HgeneMETC0547065Mixed oligoastrocytoma1CTD_human
HgeneMETC0750935Cerebral Astrocytoma1CTD_human
HgeneMETC0750936Intracranial Astrocytoma1CTD_human
HgeneMETC0919267ovarian neoplasm1CTD_human
HgeneMETC1140680Malignant neoplasm of ovary1CTD_human
HgeneMETC1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneMETC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneMETC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneMETC1621958Glioblastoma Multiforme1CTD_human
HgeneMETC1704230Grade I Astrocytoma1CTD_human
HgeneMETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome1CLINGEN
HgeneMETC1876165Copper-Overload Cirrhosis1CTD_human
HgeneMETC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneMETC2239176Liver carcinoma1CGI;CTD_human;UNIPROT
HgeneMETC3711374Nonsyndromic Deafness1CLINGEN
HgeneMETC4084709DEAFNESS, AUTOSOMAL RECESSIVE 971CTD_human;UNIPROT
TgeneCFTRC0010674Cystic Fibrosis91CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCFTRC0392164Pulmonary Cystic Fibrosis15CTD_human
TgeneCFTRC1527396Fibrocystic Disease of Pancreas15CTD_human
TgeneCFTRC0403814Congenital bilateral aplasia of vas deferens8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCFTRC0238339Hereditary pancreatitis3CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneCFTRC0021364Male infertility2CTD_human
TgeneCFTRC0030305Pancreatitis2CTD_human
TgeneCFTRC0267937Acute recurrent pancreatitis2ORPHANET
TgeneCFTRC0339985Idiopathic bronchiectasis2ORPHANET
TgeneCFTRC0848676Subfertility, Male2CTD_human
TgeneCFTRC0917731Male sterility2CTD_human
TgeneCFTRC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneCFTRC0004509Azoospermia1CTD_human
TgeneCFTRC0008340Choledochal Cyst1CTD_human
TgeneCFTRC0008370Cholestasis1GENOMICS_ENGLAND
TgeneCFTRC0009402Colorectal Carcinoma1CTD_human
TgeneCFTRC0009404Colorectal Neoplasms1CTD_human
TgeneCFTRC0009439Choledochal Cyst, Type I1CTD_human
TgeneCFTRC0013146Drug abuse1CTD_human
TgeneCFTRC0013170Drug habituation1CTD_human
TgeneCFTRC0013222Drug Use Disorders1CTD_human
TgeneCFTRC0019284Diaphragmatic Hernia1CTD_human
TgeneCFTRC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneCFTRC0035455Rhinitis1CTD_human
TgeneCFTRC0037199Sinusitis1CTD_human
TgeneCFTRC0038580Substance Dependence1CTD_human
TgeneCFTRC0038586Substance Use Disorders1CTD_human
TgeneCFTRC0085548Autosomal Recessive Polycystic Kidney Disease1CTD_human
TgeneCFTRC0149521Pancreatitis, Chronic1CTD_human
TgeneCFTRC0236969Substance-Related Disorders1CTD_human
TgeneCFTRC0740858Substance abuse problem1CTD_human
TgeneCFTRC1257796Choledochal Cyst, Type II1CTD_human
TgeneCFTRC1257797Choledochal Cyst, Type III1CTD_human
TgeneCFTRC1257798Choledochal Cyst, Type IV1CTD_human
TgeneCFTRC1257799Choledochal Cyst, Type V1CTD_human
TgeneCFTRC1510472Drug Dependence1CTD_human
TgeneCFTRC4316881Prescription Drug Abuse1CTD_human