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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:METTL5-MERTK (FusionGDB2 ID:52819) |
Fusion Gene Summary for METTL5-MERTK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: METTL5-MERTK | Fusion gene ID: 52819 | Hgene | Tgene | Gene symbol | METTL5 | MERTK | Gene ID | 29081 | 10461 |
| Gene name | methyltransferase like 5 | MER proto-oncogene, tyrosine kinase | |
| Synonyms | HSPC133|MRT72 | MER|RP38|Tyro12|c-Eyk|c-mer | |
| Cytomap | 2q31.1 | 2q13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methyltransferase-like protein 5 | tyrosine-protein kinase MerMER receptor tyrosine kinaseSTK kinasec-mer proto-oncogene tyrosine kinaseproto-oncogene c-Merreceptor tyrosine kinase MerTK | |
| Modification date | 20200327 | 20200329 | |
| UniProtAcc | Q9NRN9 | Q12866 | |
| Ensembl transtripts involved in fusion gene | ENST00000409837, ENST00000409340, ENST00000260953, ENST00000409965, ENST00000392640, ENST00000308099, ENST00000410097, | ENST00000295408, ENST00000421804, ENST00000409780, | |
| Fusion gene scores | * DoF score | 4 X 6 X 4=96 | 7 X 10 X 8=560 |
| # samples | 7 | 13 | |
| ** MAII score | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/560*10)=-2.10691520391651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: METTL5 [Title/Abstract] AND MERTK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | METTL5(170676071)-MERTK(112785928), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | METTL5-MERTK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. METTL5-MERTK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MERTK | GO:0050766 | positive regulation of phagocytosis | 18395422 |
| Fusion gene breakpoints across METTL5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across MERTK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-ER-A3EV-06A | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| ChimerDB4 | SKCM | TCGA-ER-A3EV-06A | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| ChimerDB4 | SKCM | TCGA-ER-A3EV-06A | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
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Fusion Gene ORF analysis for METTL5-MERTK |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000409837 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000409837 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000409837 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000409340 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000409340 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000409340 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000260953 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000260953 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000260953 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000409965 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000409965 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000409965 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000392640 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000392640 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000392640 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| intron-3CDS | ENST00000308099 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| intron-3CDS | ENST00000308099 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| intron-3CDS | ENST00000308099 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000410097 | ENST00000295408 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| In-frame | ENST00000410097 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| Frame-shift | ENST00000410097 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000409837 | METTL5 | chr2 | 170676071 | - | ENST00000409780 | MERTK | chr2 | 112785928 | + | 1587 | 570 | 511 | 1083 | 190 |
| ENST00000409340 | METTL5 | chr2 | 170676071 | - | ENST00000421804 | MERTK | chr2 | 112785928 | + | 1254 | 268 | 209 | 781 | 190 |
| ENST00000260953 | METTL5 | chr2 | 170676071 | - | ENST00000421804 | MERTK | chr2 | 112785928 | + | 1792 | 806 | 747 | 1319 | 190 |
| ENST00000409965 | METTL5 | chr2 | 170676071 | - | ENST00000421804 | MERTK | chr2 | 112785928 | + | 1662 | 676 | 617 | 1189 | 190 |
| ENST00000392640 | METTL5 | chr2 | 170676071 | - | ENST00000409780 | MERTK | chr2 | 112785928 | + | 1613 | 596 | 537 | 1109 | 190 |
| ENST00000410097 | METTL5 | chr2 | 170676071 | - | ENST00000421804 | MERTK | chr2 | 112785928 | + | 1611 | 625 | 566 | 1138 | 190 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000409837 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + | 0.002484571 | 0.99751544 |
| ENST00000409340 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + | 0.003277651 | 0.9967224 |
| ENST00000260953 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + | 0.00361741 | 0.9963826 |
| ENST00000409965 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + | 0.001984217 | 0.99801576 |
| ENST00000392640 | ENST00000409780 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + | 0.001678341 | 0.9983216 |
| ENST00000410097 | ENST00000421804 | METTL5 | chr2 | 170676071 | - | MERTK | chr2 | 112785928 | + | 0.002347504 | 0.9976525 |
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Fusion Genomic Features for METTL5-MERTK |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for METTL5-MERTK |
| Go to FGviewer for the breakpoints of chr2:170676071-chr2:112785928 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| METTL5 | MERTK |
| FUNCTION: Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:31328227, PubMed:32217665). N6-methylation of adenine(1832) in 18S rRNA is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K1A0, ECO:0000269|PubMed:31328227, ECO:0000269|PubMed:32217665}. | FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:17005688}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | METTL5 | chr2:170676071 | chr2:112785928 | ENST00000260953 | - | 4 | 7 | 108_109 | 163.0 | 210.0 | Region | S-adenosyl-L-methionine binding |
| Hgene | METTL5 | chr2:170676071 | chr2:112785928 | ENST00000392640 | - | 5 | 8 | 108_109 | 163.0 | 210.0 | Region | S-adenosyl-L-methionine binding |
| Hgene | METTL5 | chr2:170676071 | chr2:112785928 | ENST00000409965 | - | 5 | 8 | 108_109 | 163.0 | 210.0 | Region | S-adenosyl-L-methionine binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000295408 | 17 | 19 | 197_273 | 828.6666666666666 | 1000.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000295408 | 17 | 19 | 286_381 | 828.6666666666666 | 1000.0 | Domain | Fibronectin type-III 1 | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000295408 | 17 | 19 | 386_484 | 828.6666666666666 | 1000.0 | Domain | Fibronectin type-III 2 | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000295408 | 17 | 19 | 587_858 | 828.6666666666666 | 1000.0 | Domain | Protein kinase | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000295408 | 17 | 19 | 81_186 | 828.6666666666666 | 1000.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000421804 | 17 | 20 | 197_273 | 828.6666666666666 | 951.3333333333334 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000421804 | 17 | 20 | 286_381 | 828.6666666666666 | 951.3333333333334 | Domain | Fibronectin type-III 1 | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000421804 | 17 | 20 | 386_484 | 828.6666666666666 | 951.3333333333334 | Domain | Fibronectin type-III 2 | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000421804 | 17 | 20 | 587_858 | 828.6666666666666 | 951.3333333333334 | Domain | Protein kinase | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000421804 | 17 | 20 | 81_186 | 828.6666666666666 | 951.3333333333334 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000295408 | 17 | 19 | 593_601 | 828.6666666666666 | 1000.0 | Nucleotide binding | ATP | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000421804 | 17 | 20 | 593_601 | 828.6666666666666 | 951.3333333333334 | Nucleotide binding | ATP | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000295408 | 17 | 19 | 21_505 | 828.6666666666666 | 1000.0 | Topological domain | Extracellular | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000295408 | 17 | 19 | 527_999 | 828.6666666666666 | 1000.0 | Topological domain | Cytoplasmic | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000421804 | 17 | 20 | 21_505 | 828.6666666666666 | 951.3333333333334 | Topological domain | Extracellular | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000421804 | 17 | 20 | 527_999 | 828.6666666666666 | 951.3333333333334 | Topological domain | Cytoplasmic | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000295408 | 17 | 19 | 506_526 | 828.6666666666666 | 1000.0 | Transmembrane | Helical | |
| Tgene | MERTK | chr2:170676071 | chr2:112785928 | ENST00000421804 | 17 | 20 | 506_526 | 828.6666666666666 | 951.3333333333334 | Transmembrane | Helical |
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Fusion Gene Sequence for METTL5-MERTK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000409837_ENST00000409780_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(transcript)=1587nt_BP=570nt GCTTCCGGCACCGGCCGAGGTGCGGGTCGCCTCCAGAGATCCTGTGCCTTCAAACCCTACGAGTCCATACTTTAAAACAAAATGAAGAAA GTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCTACCAGGCCG CACATTGCAGCATGTATGCTCTATACAATCCATAACACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCTAGGATGTGGTTGTGGA GTACTTAGCATCGGAACTGCAATGTTAGGAGCAGGGTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGAAATATTTAATAGGAAT GCAGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAAGTCATTCGATACAGTA ATTATGAATCCTCCCTTTGGGACCAAAAATAATAAAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGAACAGCAGTA TATTCCTTACACAAATCCTCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCACCTTTTCAGT ATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACAGTTGCTGGA GAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTGCACTCCCCG CGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGAGGAATGGGA AGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGGGGTCTCCTG GTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCATTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGAAGTCCTGAT GTGAGGAGAGGTGCGGGGAGACATTCCAAAAATCAAGCCAATTCTTCTGCTGTAGGAGAATCCAATTGTACCTGATGTTTTTGGTATTTG TCTTCCTTACCAAGTGAACTCCATGGCCCCAAAGCACCAGATGAATGTTGTTAAGTAAGCTGTCATTAAAAATACATAATATATATTTAT TTAAAGAGAAAAAATATGTGTATATCATGGAAAAAGACAAGGATATTTTAATAAAACATTACTTATTTCATTTCACTTATCTTGCATATC TTAAAATTAAGCTTCAGCTGCTCCTTGATATTAACATTTGTACAGAGTTGAAGTTGTTTTTTCAAGTTCTTTTCTTTTTCATGACTATTA AATGTAAAAATATTTGTAAAATGAAATGCCATATTTGACTTGGCTTCTGGTCTTGATGTATTTGATAAGAATGATTCATTCAATGTTTAA >In-frame_ENST00000409837_ENST00000409780_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(amino acids)=190AA_start in transcript=511_stop in transcript=1083 MLWKWQEQQYIPYTNPQLEKYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDP DSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFAD -------------------------------------------------------------- >In-frame_ENST00000409340_ENST00000421804_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(transcript)=1254nt_BP=268nt CCGTCTCCTGGGGCGGCTTGGGTTAGCCGGGAGATCCTGTGCCTTCAAACCCTACGAGTCCATACTTTAAAACAAAATGAAGAAAGTAAG GCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCTACCAGGCCGCACAT TGCAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGAACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGT ATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAA GTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACAGTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCC TTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTC ATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGAGGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCA CAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGGGGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCT CATTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGAAGTCCTGATGTGAGGAGAGGTGCGGGGAGACATTCCAAAAA TCAAGCCAATTCTTCTGCTGTAGGAGAATCCAATTGTACCTGATGTTTTTGGTATTTGTCTTCCTTACCAAGTGAACTCCATGGCCCCAA AGCACCAGATGAATGTTGTTAAGTAAGCTGTCATTAAAAATACATAATATATATTTATTTAAAGAGAAAAAATATGTGTATATCATGGAA AAAGACAAGGATATTTTAATAAAACATTACTTATTTCATTTCACTTATCTTGCATATCTTAAAATTAAGCTTCAGCTGCTCCTTGATATT AACATTTGTACAGAGTTGAAGTTGTTTTTTCAAGTTCTTTTCTTTTTCATGACTATTAAATGTAAAAATATTTGTAAAATGAAATGCCAT >In-frame_ENST00000409340_ENST00000421804_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(amino acids)=190AA_start in transcript=209_stop in transcript=781 MLWKWQEQQYIPYTNPQLEKYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDP DSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFAD -------------------------------------------------------------- >In-frame_ENST00000260953_ENST00000421804_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(transcript)=1792nt_BP=806nt CGGCCTGGCGCTTCCGGCACCGGCCGAGGTGCGGGTCGCCTCCAGAGGTGCGTGGTCGTGGCGCGAGGGATCCTGAGGCTGCTCCAGCAG TGCGCCGCCGCCGTCTCCTGGGGCGGCTTGGGTTAGCCGGGAGGTGGGTCAGAGGCTCGCCCCGTGCCCTGCGTCCGGGCGTCTCCTTAG GGCGCGTCTTCGGGTCCGGCCAGCGGTGCTGAAAAAGGGAGAAGGTTGGGGGTAGGGAGGAAACAAGATCCCAGTTCAATAGATTTCTCC GCAGATCCTGTGCCTTCAAACCCTACGAGTCCATACTTTAAAACAAAATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAAC AAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCTACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATA ACACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCTAGGATGTGGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAG GGTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGAAATATTTAATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGG TTCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAAGTCATTCGATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATA AAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGAACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTAT GAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGT TTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACAGTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTT GCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCAT GACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGAGGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACA GCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGGGGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCA TTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGAAGTCCTGATGTGAGGAGAGGTGCGGGGAGACATTCCAAAAATC AAGCCAATTCTTCTGCTGTAGGAGAATCCAATTGTACCTGATGTTTTTGGTATTTGTCTTCCTTACCAAGTGAACTCCATGGCCCCAAAG CACCAGATGAATGTTGTTAAGTAAGCTGTCATTAAAAATACATAATATATATTTATTTAAAGAGAAAAAATATGTGTATATCATGGAAAA AGACAAGGATATTTTAATAAAACATTACTTATTTCATTTCACTTATCTTGCATATCTTAAAATTAAGCTTCAGCTGCTCCTTGATATTAA CATTTGTACAGAGTTGAAGTTGTTTTTTCAAGTTCTTTTCTTTTTCATGACTATTAAATGTAAAAATATTTGTAAAATGAAATGCCATAT >In-frame_ENST00000260953_ENST00000421804_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(amino acids)=190AA_start in transcript=747_stop in transcript=1319 MLWKWQEQQYIPYTNPQLEKYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDP DSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFAD -------------------------------------------------------------- >In-frame_ENST00000409965_ENST00000421804_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(transcript)=1662nt_BP=676nt GTGCGCGCGTGCGGCCTGGCGCTTCCGGCACCGGCCGAGGTGCGGGTCGCCTCCAGAGGTGCGTGGTCGTGGCGCGAGGGATCCTGAGGC TGCTCCAGCAGTGCGCCGCCGCCGTCTCCTGGGGCGGCTTGGGTTAGCCGGGAGATCCTGTGCCTTCAAACCCTACGAGTCCATACTTTA AAACAAAATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACA GTATCCTACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATAACACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCT AGGATGTGGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAGGGTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGA AATATTTAATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAA GTCATTCGATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATAAAGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAAT GGCAAGAACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACC GCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCA ATACACAGTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGACTCTATAATTG CCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGG GCAGTGAGGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTA GGAATGGGGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCATTGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAG GCTCAGAAGTCCTGATGTGAGGAGAGGTGCGGGGAGACATTCCAAAAATCAAGCCAATTCTTCTGCTGTAGGAGAATCCAATTGTACCTG ATGTTTTTGGTATTTGTCTTCCTTACCAAGTGAACTCCATGGCCCCAAAGCACCAGATGAATGTTGTTAAGTAAGCTGTCATTAAAAATA CATAATATATATTTATTTAAAGAGAAAAAATATGTGTATATCATGGAAAAAGACAAGGATATTTTAATAAAACATTACTTATTTCATTTC ACTTATCTTGCATATCTTAAAATTAAGCTTCAGCTGCTCCTTGATATTAACATTTGTACAGAGTTGAAGTTGTTTTTTCAAGTTCTTTTC TTTTTCATGACTATTAAATGTAAAAATATTTGTAAAATGAAATGCCATATTTGACTTGGCTTCTGGTCTTGATGTATTTGATAAGAATGA >In-frame_ENST00000409965_ENST00000421804_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(amino acids)=190AA_start in transcript=617_stop in transcript=1189 MLWKWQEQQYIPYTNPQLEKYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDP DSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFAD -------------------------------------------------------------- >In-frame_ENST00000392640_ENST00000409780_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(transcript)=1613nt_BP=596nt GAACGCGTGCGCGCGTGCGGCCTGGCGCTTCCGGCACCGGCCGAGGTGCGGGTCGCCTCCAGAGATCCTGTGCCTTCAAACCCTACGAGT CCATACTTTAAAACAAAATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACAAGTGGATGGATTTGAAAAGCCCAAGCTAC TTCTGGAACAGTATCCTACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATAACACTTATGATGACATTGAAAATAAAGTCG TTGCAGATCTAGGATGTGGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAGGGTTGTGTGTTGGATTTGACATAGATGAAG ACGCATTGGAAATATTTAATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGGTTCAATGTGATGTGTGCTTATTATCTAACA GAATGTCCAAGTCATTCGATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATAAAGGGACAGATATGGCTTTTCTAAAGACTG CTTTGGAAATGGCAAGAACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTATGAAATAATGTACTCTTGCTGGAGAACCGAT CCCTTAGACCGCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTTTGCCTGACGTTCGGAACCAAGCAGACGTT ATTTACGTCAATACACAGTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTGCTCCACTGGACTTGAACATCGACCCTGAC TCTATAATTGCCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATGACAGCAAACCTCATGAAGGACGGTACATC CTGAATGGGGGCAGTGAGGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAGCTGAAAAGAACAGTGTTTTACCGGGGGAG AGACTTGTTAGGAATGGGGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCATTGCCCGATGAACTTTTGTTTGCTGACGAC TCCTCAGAAGGCTCAGAAGTCCTGATGTGAGGAGAGGTGCGGGGAGACATTCCAAAAATCAAGCCAATTCTTCTGCTGTAGGAGAATCCA ATTGTACCTGATGTTTTTGGTATTTGTCTTCCTTACCAAGTGAACTCCATGGCCCCAAAGCACCAGATGAATGTTGTTAAGTAAGCTGTC ATTAAAAATACATAATATATATTTATTTAAAGAGAAAAAATATGTGTATATCATGGAAAAAGACAAGGATATTTTAATAAAACATTACTT ATTTCATTTCACTTATCTTGCATATCTTAAAATTAAGCTTCAGCTGCTCCTTGATATTAACATTTGTACAGAGTTGAAGTTGTTTTTTCA AGTTCTTTTCTTTTTCATGACTATTAAATGTAAAAATATTTGTAAAATGAAATGCCATATTTGACTTGGCTTCTGGTCTTGATGTATTTG >In-frame_ENST00000392640_ENST00000409780_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(amino acids)=190AA_start in transcript=537_stop in transcript=1109 MLWKWQEQQYIPYTNPQLEKYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDP DSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFAD -------------------------------------------------------------- >In-frame_ENST00000410097_ENST00000421804_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(transcript)=1611nt_BP=625nt TCCAGAGGTGCGTGGTCGTGGCGCGAGGGATCCTGAGGCTGCTCCAGCAGTGCGCCGCCGCCGTCTCCTGGGGCGGCTTGGGTTAGCCGG GAGATCCTGTGCCTTCAAACCCTACGAGTCCATACTTTAAAACAAAATGAAGAAAGTAAGGCTTAAGGAACTAGAGAGTCGCCTGCAACA AGTGGATGGATTTGAAAAGCCCAAGCTACTTCTGGAACAGTATCCTACCAGGCCGCACATTGCAGCATGTATGCTCTATACAATCCATAA CACTTATGATGACATTGAAAATAAAGTCGTTGCAGATCTAGGATGTGGTTGTGGAGTACTTAGCATCGGAACTGCAATGTTAGGAGCAGG GTTGTGTGTTGGATTTGACATAGATGAAGACGCATTGGAAATATTTAATAGGAATGCAGAAGAGTTTGAGTTAACAAATATTGACATGGT TCAATGTGATGTGTGCTTATTATCTAACAGAATGTCCAAGTCATTCGATACAGTAATTATGAATCCTCCCTTTGGGACCAAAAATAATAA AGGGACAGATATGGCTTTTCTAAAGACTGCTTTGGAAATGGCAAGAACAGCAGTATATTCCTTACACAAATCCTCAACTAGAGAAGTATG AAATAATGTACTCTTGCTGGAGAACCGATCCCTTAGACCGCCCCACCTTTTCAGTATTGAGGCTGCAGCTAGAAAAACTCTTAGAAAGTT TGCCTGACGTTCGGAACCAAGCAGACGTTATTTACGTCAATACACAGTTGCTGGAGAGCTCTGAGGGCCTGGCCCAGGGCTCCACCCTTG CTCCACTGGACTTGAACATCGACCCTGACTCTATAATTGCCTCCTGCACTCCCCGCGCTGCCATCAGTGTGGTCACAGCAGAAGTTCATG ACAGCAAACCTCATGAAGGACGGTACATCCTGAATGGGGGCAGTGAGGAATGGGAAGATCTGACTTCTGCCCCCTCTGCTGCAGTCACAG CTGAAAAGAACAGTGTTTTACCGGGGGAGAGACTTGTTAGGAATGGGGTCTCCTGGTCCCATTCGAGCATGCTGCCCTTGGGAAGCTCAT TGCCCGATGAACTTTTGTTTGCTGACGACTCCTCAGAAGGCTCAGAAGTCCTGATGTGAGGAGAGGTGCGGGGAGACATTCCAAAAATCA AGCCAATTCTTCTGCTGTAGGAGAATCCAATTGTACCTGATGTTTTTGGTATTTGTCTTCCTTACCAAGTGAACTCCATGGCCCCAAAGC ACCAGATGAATGTTGTTAAGTAAGCTGTCATTAAAAATACATAATATATATTTATTTAAAGAGAAAAAATATGTGTATATCATGGAAAAA GACAAGGATATTTTAATAAAACATTACTTATTTCATTTCACTTATCTTGCATATCTTAAAATTAAGCTTCAGCTGCTCCTTGATATTAAC ATTTGTACAGAGTTGAAGTTGTTTTTTCAAGTTCTTTTCTTTTTCATGACTATTAAATGTAAAAATATTTGTAAAATGAAATGCCATATT >In-frame_ENST00000410097_ENST00000421804_TCGA-ER-A3EV-06A_METTL5_chr2_170676071_-_MERTK_chr2_112785928_length(amino acids)=190AA_start in transcript=566_stop in transcript=1138 MLWKWQEQQYIPYTNPQLEKYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDP DSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFAD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for METTL5-MERTK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for METTL5-MERTK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MERTK | Q12866 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
| Tgene | MERTK | Q12866 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for METTL5-MERTK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | METTL5 | C0025958 | Microcephaly | 1 | GENOMICS_ENGLAND |
| Hgene | METTL5 | C0233514 | Abnormal behavior | 1 | GENOMICS_ENGLAND |
| Hgene | METTL5 | C0454644 | Delayed speech and language development | 1 | GENOMICS_ENGLAND |
| Hgene | METTL5 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
| Tgene | MERTK | C0007097 | Carcinoma | 1 | CTD_human |
| Tgene | MERTK | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| Tgene | MERTK | C0034065 | Pulmonary Embolism | 1 | CTD_human |
| Tgene | MERTK | C0035334 | Retinitis Pigmentosa | 1 | CTD_human;GENOMICS_ENGLAND |
| Tgene | MERTK | C0040038 | Thromboembolism | 1 | CTD_human |
| Tgene | MERTK | C0040053 | Thrombosis | 1 | CTD_human |
| Tgene | MERTK | C0087086 | Thrombus | 1 | CTD_human |
| Tgene | MERTK | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
| Tgene | MERTK | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
| Tgene | MERTK | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
| Tgene | MERTK | C0205699 | Carcinomatosis | 1 | CTD_human |
| Tgene | MERTK | C0524702 | Pulmonary Thromboembolisms | 1 | CTD_human |
| Tgene | MERTK | C1708353 | Hereditary Paraganglioma-Pheochromocytoma Syndrome | 1 | CLINGEN |
| Tgene | MERTK | C3151228 | RETINITIS PIGMENTOSA 38 (disorder) | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
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