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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MGST1-ADTRP (FusionGDB2 ID:53115)

Fusion Gene Summary for MGST1-ADTRP

check button Fusion gene summary
Fusion gene informationFusion gene name: MGST1-ADTRP
Fusion gene ID: 53115
HgeneTgene
Gene symbol

MGST1

ADTRP

Gene ID

4257

84830

Gene namemicrosomal glutathione S-transferase 1androgen dependent TFPI regulating protein
SynonymsGST12|MGST|MGST-IAIG1L|C6orf105|dJ413H6.1
Cytomap

12p12.3

6p24.1

Type of geneprotein-codingprotein-coding
Descriptionmicrosomal glutathione S-transferase 1glutathione S-transferase 12microsomal GST-1microsomal GST-Iandrogen-dependent TFPI-regulating proteinFAHFA hydrolase ADTRPandrogen-dependent TPF1-regulating proteinfatty acid esters of hydroxy fatty acids hydrolase ADTRP
Modification date2020032020200313
UniProtAcc

P10620

Q96IZ2

Ensembl transtripts involved in fusion geneENST00000010404, ENST00000396210, 
ENST00000535309, ENST00000540056, 
ENST00000396209, ENST00000396207, 
ENST00000359720, 		ENST00000414691, 
ENST00000514824, ENST00000229583, 
ENST00000379413, 
Fusion gene scores* DoF score13 X 8 X 6=6247 X 6 X 6=252
# samples 138
** MAII scorelog2(13/624*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MGST1 [Title/Abstract] AND ADTRP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMGST1(16510633)-ADTRP(11723733), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMGST1

GO:0055114

oxidation-reduction process

20727966

HgeneMGST1

GO:0071449

cellular response to lipid hydroperoxide

20727966


check buttonFusion gene breakpoints across MGST1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ADTRP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-AAVR-01AMGST1chr12

16510633

+ADTRPchr6

11723733

-


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Fusion Gene ORF analysis for MGST1-ADTRP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000010404ENST00000414691MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000010404ENST00000514824MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000010404ENST00000229583MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000010404ENST00000379413MGST1chr12

16510633

+ADTRPchr6

11723733

-
In-frameENST00000396210ENST00000414691MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000396210ENST00000514824MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000396210ENST00000229583MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000396210ENST00000379413MGST1chr12

16510633

+ADTRPchr6

11723733

-
In-frameENST00000535309ENST00000414691MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000535309ENST00000514824MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000535309ENST00000229583MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000535309ENST00000379413MGST1chr12

16510633

+ADTRPchr6

11723733

-
intron-3CDSENST00000540056ENST00000414691MGST1chr12

16510633

+ADTRPchr6

11723733

-
intron-5UTRENST00000540056ENST00000514824MGST1chr12

16510633

+ADTRPchr6

11723733

-
intron-5UTRENST00000540056ENST00000229583MGST1chr12

16510633

+ADTRPchr6

11723733

-
intron-5UTRENST00000540056ENST00000379413MGST1chr12

16510633

+ADTRPchr6

11723733

-
In-frameENST00000396209ENST00000414691MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000396209ENST00000514824MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000396209ENST00000229583MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000396209ENST00000379413MGST1chr12

16510633

+ADTRPchr6

11723733

-
In-frameENST00000396207ENST00000414691MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000396207ENST00000514824MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000396207ENST00000229583MGST1chr12

16510633

+ADTRPchr6

11723733

-
5CDS-5UTRENST00000396207ENST00000379413MGST1chr12

16510633

+ADTRPchr6

11723733

-
intron-3CDSENST00000359720ENST00000414691MGST1chr12

16510633

+ADTRPchr6

11723733

-
intron-5UTRENST00000359720ENST00000514824MGST1chr12

16510633

+ADTRPchr6

11723733

-
intron-5UTRENST00000359720ENST00000229583MGST1chr12

16510633

+ADTRPchr6

11723733

-
intron-5UTRENST00000359720ENST00000379413MGST1chr12

16510633

+ADTRPchr6

11723733

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000010404MGST1chr1216510633+ENST00000414691ADTRPchr611723733-142728665472135
ENST00000396210MGST1chr1216510633+ENST00000414691ADTRPchr611723733-14463056491161
ENST00000535309MGST1chr1216510633+ENST00000414691ADTRPchr611723733-140126039446135
ENST00000396209MGST1chr1216510633+ENST00000414691ADTRPchr611723733-1505364107550147
ENST00000396207MGST1chr1216510633+ENST00000414691ADTRPchr611723733-143529473480135

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000010404ENST00000414691MGST1chr1216510633+ADTRPchr611723733-0.010408240.9895918
ENST00000396210ENST00000414691MGST1chr1216510633+ADTRPchr611723733-0.0069031650.9930969
ENST00000535309ENST00000414691MGST1chr1216510633+ADTRPchr611723733-0.0116268060.9883732
ENST00000396209ENST00000414691MGST1chr1216510633+ADTRPchr611723733-0.0084326390.9915673
ENST00000396207ENST00000414691MGST1chr1216510633+ADTRPchr611723733-0.0100289360.9899711

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Fusion Genomic Features for MGST1-ADTRP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MGST1-ADTRP


check button Go to

FGviewer for the breakpoints of chr12:16510633-chr6:11723733

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MGST1

P10620

ADTRP

Q96IZ2

FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.FUNCTION: Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574). {ECO:0000269|PubMed:21868574, ECO:0000269|PubMed:27018888}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMGST1chr12:16510633chr6:11723733ENST00000010404+3434_6273.66666666666667156.0Topological domainCytoplasmic
HgeneMGST1chr12:16510633chr6:11723733ENST00000010404+343_973.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000396207+3434_6273.66666666666667156.0Topological domainCytoplasmic
HgeneMGST1chr12:16510633chr6:11723733ENST00000396207+343_973.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000396209+3434_6273.66666666666667156.0Topological domainCytoplasmic
HgeneMGST1chr12:16510633chr6:11723733ENST00000396209+343_973.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000396210+3434_6273.66666666666667156.0Topological domainCytoplasmic
HgeneMGST1chr12:16510633chr6:11723733ENST00000396210+343_973.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000535309+3434_6273.6666666666666788.0Topological domainCytoplasmic
HgeneMGST1chr12:16510633chr6:11723733ENST00000535309+343_973.6666666666666788.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000010404+3410_3373.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396207+3410_3373.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396209+3410_3373.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396210+3410_3373.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000535309+3410_3373.6666666666666788.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST0000022958347211_230186.66666666666666249.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST0000037941336176_189168.66666666666666256.0Topological domainExtracellular
TgeneADTRPchr12:16510633chr6:11723733ENST0000037941336211_230168.66666666666666256.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST0000041469136176_189168.66666666666666231.0Topological domainExtracellular
TgeneADTRPchr12:16510633chr6:11723733ENST0000041469136211_230168.66666666666666231.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST0000022958347190_210186.66666666666666249.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST0000037941336190_210168.66666666666666256.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST0000041469136190_210168.66666666666666231.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMGST1chr12:16510633chr6:11723733ENST00000010404+34124_12873.66666666666667156.0Topological domainCytoplasmic
HgeneMGST1chr12:16510633chr6:11723733ENST00000010404+34149_15573.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000010404+3497_9973.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000396207+34124_12873.66666666666667156.0Topological domainCytoplasmic
HgeneMGST1chr12:16510633chr6:11723733ENST00000396207+34149_15573.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000396207+3497_9973.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000396209+34124_12873.66666666666667156.0Topological domainCytoplasmic
HgeneMGST1chr12:16510633chr6:11723733ENST00000396209+34149_15573.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000396209+3497_9973.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000396210+34124_12873.66666666666667156.0Topological domainCytoplasmic
HgeneMGST1chr12:16510633chr6:11723733ENST00000396210+34149_15573.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000396210+3497_9973.66666666666667156.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000535309+34124_12873.6666666666666788.0Topological domainCytoplasmic
HgeneMGST1chr12:16510633chr6:11723733ENST00000535309+34149_15573.6666666666666788.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000535309+3497_9973.6666666666666788.0Topological domainLumenal
HgeneMGST1chr12:16510633chr6:11723733ENST00000010404+34100_12373.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000010404+34129_14873.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000010404+3463_9673.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396207+34100_12373.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396207+34129_14873.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396207+3463_9673.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396209+34100_12373.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396209+34129_14873.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396209+3463_9673.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396210+34100_12373.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396210+34129_14873.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000396210+3463_9673.66666666666667156.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000535309+34100_12373.6666666666666788.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000535309+34129_14873.6666666666666788.0TransmembraneHelical
HgeneMGST1chr12:16510633chr6:11723733ENST00000535309+3463_9673.6666666666666788.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST0000022958347107_119186.66666666666666249.0Topological domainExtracellular
TgeneADTRPchr12:16510633chr6:11723733ENST0000022958347141_154186.66666666666666249.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST0000022958347176_189186.66666666666666249.0Topological domainExtracellular
TgeneADTRPchr12:16510633chr6:11723733ENST00000229583471_3186.66666666666666249.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST000002295834725_46186.66666666666666249.0Topological domainExtracellular
TgeneADTRPchr12:16510633chr6:11723733ENST000002295834768_85186.66666666666666249.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST0000037941336107_119168.66666666666666256.0Topological domainExtracellular
TgeneADTRPchr12:16510633chr6:11723733ENST0000037941336141_154168.66666666666666256.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST00000379413361_3168.66666666666666256.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST000003794133625_46168.66666666666666256.0Topological domainExtracellular
TgeneADTRPchr12:16510633chr6:11723733ENST000003794133668_85168.66666666666666256.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST0000041469136107_119168.66666666666666231.0Topological domainExtracellular
TgeneADTRPchr12:16510633chr6:11723733ENST0000041469136141_154168.66666666666666231.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST00000414691361_3168.66666666666666231.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST000004146913625_46168.66666666666666231.0Topological domainExtracellular
TgeneADTRPchr12:16510633chr6:11723733ENST000004146913668_85168.66666666666666231.0Topological domainCytoplasmic
TgeneADTRPchr12:16510633chr6:11723733ENST0000022958347120_140186.66666666666666249.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST0000022958347155_175186.66666666666666249.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST000002295834747_67186.66666666666666249.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST00000229583474_24186.66666666666666249.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST000002295834786_106186.66666666666666249.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST0000037941336120_140168.66666666666666256.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST0000037941336155_175168.66666666666666256.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST000003794133647_67168.66666666666666256.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST00000379413364_24168.66666666666666256.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST000003794133686_106168.66666666666666256.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST0000041469136120_140168.66666666666666231.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST0000041469136155_175168.66666666666666231.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST000004146913647_67168.66666666666666231.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST00000414691364_24168.66666666666666231.0TransmembraneHelical
TgeneADTRPchr12:16510633chr6:11723733ENST000004146913686_106168.66666666666666231.0TransmembraneHelical


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Fusion Gene Sequence for MGST1-ADTRP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000010404_ENST00000414691_TCGA-DD-AAVR-01A_MGST1_chr12_16510633_+_ADTRP_chr6_11723733_length(transcript)=1427nt_BP=286nt
TCGTGACAAAGCAAATTGTCTGGTATCATGAATTTGGAACACCATTCCAGACCAAAATTGAAAAAATGGTTGACCTCACCCAGGTAATGG
ATGATGAAGTATTCATGGCTTTTGCATCCTATGCAACAATTATTCTTTCAAAAATGATGCTTATGAGTACTGCAACTGCATTCTATAGAT
TGACAAGAAAGGTTTTTGCCAATCCAGAAGACTGTGTAGCATTTGGCAAAGGAGAAAATGCCAAGAAGTATCTTCGAACAGATGACAGAG
TAGAACGTGTACGCAGCATCCTATGGCTCTACTTTGAGACGGGTACCTGGGTGTATCCTGTGTTTGCCAAACTCAGCCTCTTGGGTCTAG
CAGCTTTCTTCTCTCTCAGCTACGTCTTCATCGCCAGCATCTACCTACTTGGAGAGAAGCTCAACCACTGGAAATGGGGTGACATGAGGC
AGCCACGGAAGAAGAGGAAGTAATTGCACACCATTTTCCAAGAACCAAGAAAGAAGAAAACACAAGAGATTTTTCTCATCTTTTTTTTTT
TTTTCTGGTGGAGGGAGGTGGTGGAGGAACATAGCAAAGTAGGAGGGACAGAGAGTGATACTTAAATTTAATAAGAGGTTCGTGAAGGTA
GCTTAACTTGAGAACTCTTGGTTTTTTGAAAGGTTGACTGCACATGCCAAAAACAACTCCTGCTATCTCAGAATTAATTATCTTTGACCT
TCGTGGAGGATGGTCTCTGGTTAAAATCTGGCCAAAGAAACTCACATAAACTTGGTGTTAGAGAACATCTAGAGAGAGAGAGAGGAACTT
AGAGTCATTTAAACTCTTCAGTTTACAGAGAAGGATGCTGAGGACCTAGATGAGAAGTTACCTGCAAAAGGCAAAAGGGTTACTTAGTGT
CAGAACCAAGGCAATGACTTCTCTCTCCCAGATCTCCTAGCTACTGGTCCTGGGCCATTTTTTTTTTTTTAAATAATCCCAACTTTCTTT
AAAAGACAAGCATTTCAGTAAGCTAGTTATTTTCATGGGTTGCTCATCCATTTTTTTCAGTGATCTAAAAATGTAGGGAGATGGCTACTA
CTGAAGTTGTCTGTCTACTTGGGATAATAGCAAATTAATTGAAGACAATGGGAAAGTAAGTTATAAAAAATACTGGGAAATCTGTTTCTC
TTCTGAGCAAGCATTCAGGGCAGGTATAAACATCAAACATAGTGACATTGTCAAAACCTCTTCCATTTGAACATTGATTAATTCATCAAA
TAAATGGTATAGTAATAAATTTTGCTTGCAGAAGAATCTGGATGGGAAGTGATAGAATTATAAGGGCTGTTGAGATTGCTTTGCTACAAA

>In-frame_ENST00000010404_ENST00000414691_TCGA-DD-AAVR-01A_MGST1_chr12_16510633_+_ADTRP_chr6_11723733_length(amino acids)=135AA_start in transcript=65_stop in transcript=472
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRSILWLYFETGTWVYPVF

--------------------------------------------------------------
>In-frame_ENST00000396210_ENST00000414691_TCGA-DD-AAVR-01A_MGST1_chr12_16510633_+_ADTRP_chr6_11723733_length(transcript)=1446nt_BP=305nt
CCTGCATTGCGCGCGACCCGGCGGCGGGACAGGCTTGCTGCTTCCTCCTCCTCGGCCTCACCATTCCAGACCAAAATTGAAAAAATGGTT
GACCTCACCCAGGTAATGGATGATGAAGTATTCATGGCTTTTGCATCCTATGCAACAATTATTCTTTCAAAAATGATGCTTATGAGTACT
GCAACTGCATTCTATAGATTGACAAGAAAGGTTTTTGCCAATCCAGAAGACTGTGTAGCATTTGGCAAAGGAGAAAATGCCAAGAAGTAT
CTTCGAACAGATGACAGAGTAGAACGTGTACGCAGCATCCTATGGCTCTACTTTGAGACGGGTACCTGGGTGTATCCTGTGTTTGCCAAA
CTCAGCCTCTTGGGTCTAGCAGCTTTCTTCTCTCTCAGCTACGTCTTCATCGCCAGCATCTACCTACTTGGAGAGAAGCTCAACCACTGG
AAATGGGGTGACATGAGGCAGCCACGGAAGAAGAGGAAGTAATTGCACACCATTTTCCAAGAACCAAGAAAGAAGAAAACACAAGAGATT
TTTCTCATCTTTTTTTTTTTTTTCTGGTGGAGGGAGGTGGTGGAGGAACATAGCAAAGTAGGAGGGACAGAGAGTGATACTTAAATTTAA
TAAGAGGTTCGTGAAGGTAGCTTAACTTGAGAACTCTTGGTTTTTTGAAAGGTTGACTGCACATGCCAAAAACAACTCCTGCTATCTCAG
AATTAATTATCTTTGACCTTCGTGGAGGATGGTCTCTGGTTAAAATCTGGCCAAAGAAACTCACATAAACTTGGTGTTAGAGAACATCTA
GAGAGAGAGAGAGGAACTTAGAGTCATTTAAACTCTTCAGTTTACAGAGAAGGATGCTGAGGACCTAGATGAGAAGTTACCTGCAAAAGG
CAAAAGGGTTACTTAGTGTCAGAACCAAGGCAATGACTTCTCTCTCCCAGATCTCCTAGCTACTGGTCCTGGGCCATTTTTTTTTTTTTA
AATAATCCCAACTTTCTTTAAAAGACAAGCATTTCAGTAAGCTAGTTATTTTCATGGGTTGCTCATCCATTTTTTTCAGTGATCTAAAAA
TGTAGGGAGATGGCTACTACTGAAGTTGTCTGTCTACTTGGGATAATAGCAAATTAATTGAAGACAATGGGAAAGTAAGTTATAAAAAAT
ACTGGGAAATCTGTTTCTCTTCTGAGCAAGCATTCAGGGCAGGTATAAACATCAAACATAGTGACATTGTCAAAACCTCTTCCATTTGAA
CATTGATTAATTCATCAAATAAATGGTATAGTAATAAATTTTGCTTGCAGAAGAATCTGGATGGGAAGTGATAGAATTATAAGGGCTGTT
GAGATTGCTTTGCTACAAAGCACTTTTCTGAATTAGTGTGTGGTTTAACAAAGCTGATTTCCAGATGCTTAACAAGGATTCATGATCCCT

>In-frame_ENST00000396210_ENST00000414691_TCGA-DD-AAVR-01A_MGST1_chr12_16510633_+_ADTRP_chr6_11723733_length(amino acids)=161AA_start in transcript=6_stop in transcript=491
MRATRRRDRLAASSSSASPFQTKIEKMVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLR

--------------------------------------------------------------
>In-frame_ENST00000535309_ENST00000414691_TCGA-DD-AAVR-01A_MGST1_chr12_16510633_+_ADTRP_chr6_11723733_length(transcript)=1401nt_BP=260nt
TCCTCCTCGGCCTCACCATTCCAGACCAAAATTGAAAAAATGGTTGACCTCACCCAGGTAATGGATGATGAAGTATTCATGGCTTTTGCA
TCCTATGCAACAATTATTCTTTCAAAAATGATGCTTATGAGTACTGCAACTGCATTCTATAGATTGACAAGAAAGGTTTTTGCCAATCCA
GAAGACTGTGTAGCATTTGGCAAAGGAGAAAATGCCAAGAAGTATCTTCGAACAGATGACAGAGTAGAACGTGTACGCAGCATCCTATGG
CTCTACTTTGAGACGGGTACCTGGGTGTATCCTGTGTTTGCCAAACTCAGCCTCTTGGGTCTAGCAGCTTTCTTCTCTCTCAGCTACGTC
TTCATCGCCAGCATCTACCTACTTGGAGAGAAGCTCAACCACTGGAAATGGGGTGACATGAGGCAGCCACGGAAGAAGAGGAAGTAATTG
CACACCATTTTCCAAGAACCAAGAAAGAAGAAAACACAAGAGATTTTTCTCATCTTTTTTTTTTTTTTCTGGTGGAGGGAGGTGGTGGAG
GAACATAGCAAAGTAGGAGGGACAGAGAGTGATACTTAAATTTAATAAGAGGTTCGTGAAGGTAGCTTAACTTGAGAACTCTTGGTTTTT
TGAAAGGTTGACTGCACATGCCAAAAACAACTCCTGCTATCTCAGAATTAATTATCTTTGACCTTCGTGGAGGATGGTCTCTGGTTAAAA
TCTGGCCAAAGAAACTCACATAAACTTGGTGTTAGAGAACATCTAGAGAGAGAGAGAGGAACTTAGAGTCATTTAAACTCTTCAGTTTAC
AGAGAAGGATGCTGAGGACCTAGATGAGAAGTTACCTGCAAAAGGCAAAAGGGTTACTTAGTGTCAGAACCAAGGCAATGACTTCTCTCT
CCCAGATCTCCTAGCTACTGGTCCTGGGCCATTTTTTTTTTTTTAAATAATCCCAACTTTCTTTAAAAGACAAGCATTTCAGTAAGCTAG
TTATTTTCATGGGTTGCTCATCCATTTTTTTCAGTGATCTAAAAATGTAGGGAGATGGCTACTACTGAAGTTGTCTGTCTACTTGGGATA
ATAGCAAATTAATTGAAGACAATGGGAAAGTAAGTTATAAAAAATACTGGGAAATCTGTTTCTCTTCTGAGCAAGCATTCAGGGCAGGTA
TAAACATCAAACATAGTGACATTGTCAAAACCTCTTCCATTTGAACATTGATTAATTCATCAAATAAATGGTATAGTAATAAATTTTGCT
TGCAGAAGAATCTGGATGGGAAGTGATAGAATTATAAGGGCTGTTGAGATTGCTTTGCTACAAAGCACTTTTCTGAATTAGTGTGTGGTT

>In-frame_ENST00000535309_ENST00000414691_TCGA-DD-AAVR-01A_MGST1_chr12_16510633_+_ADTRP_chr6_11723733_length(amino acids)=135AA_start in transcript=39_stop in transcript=446
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRSILWLYFETGTWVYPVF

--------------------------------------------------------------
>In-frame_ENST00000396209_ENST00000414691_TCGA-DD-AAVR-01A_MGST1_chr12_16510633_+_ADTRP_chr6_11723733_length(transcript)=1505nt_BP=364nt
GGCAGATGGAAGACTTGGGGGGGTCTCTGCCAGCTGGAAGTGCTTGGCTCCACTTAGCAGCTAAACTTAGCTTTTCAATCGATCGCTTTT
GAAAGGGAATTGTATTTCTGTCCCCGTGCGGATTCCAGACCAAAATTGAAAAAATGGTTGACCTCACCCAGGTAATGGATGATGAAGTAT
TCATGGCTTTTGCATCCTATGCAACAATTATTCTTTCAAAAATGATGCTTATGAGTACTGCAACTGCATTCTATAGATTGACAAGAAAGG
TTTTTGCCAATCCAGAAGACTGTGTAGCATTTGGCAAAGGAGAAAATGCCAAGAAGTATCTTCGAACAGATGACAGAGTAGAACGTGTAC
GCAGCATCCTATGGCTCTACTTTGAGACGGGTACCTGGGTGTATCCTGTGTTTGCCAAACTCAGCCTCTTGGGTCTAGCAGCTTTCTTCT
CTCTCAGCTACGTCTTCATCGCCAGCATCTACCTACTTGGAGAGAAGCTCAACCACTGGAAATGGGGTGACATGAGGCAGCCACGGAAGA
AGAGGAAGTAATTGCACACCATTTTCCAAGAACCAAGAAAGAAGAAAACACAAGAGATTTTTCTCATCTTTTTTTTTTTTTTCTGGTGGA
GGGAGGTGGTGGAGGAACATAGCAAAGTAGGAGGGACAGAGAGTGATACTTAAATTTAATAAGAGGTTCGTGAAGGTAGCTTAACTTGAG
AACTCTTGGTTTTTTGAAAGGTTGACTGCACATGCCAAAAACAACTCCTGCTATCTCAGAATTAATTATCTTTGACCTTCGTGGAGGATG
GTCTCTGGTTAAAATCTGGCCAAAGAAACTCACATAAACTTGGTGTTAGAGAACATCTAGAGAGAGAGAGAGGAACTTAGAGTCATTTAA
ACTCTTCAGTTTACAGAGAAGGATGCTGAGGACCTAGATGAGAAGTTACCTGCAAAAGGCAAAAGGGTTACTTAGTGTCAGAACCAAGGC
AATGACTTCTCTCTCCCAGATCTCCTAGCTACTGGTCCTGGGCCATTTTTTTTTTTTTAAATAATCCCAACTTTCTTTAAAAGACAAGCA
TTTCAGTAAGCTAGTTATTTTCATGGGTTGCTCATCCATTTTTTTCAGTGATCTAAAAATGTAGGGAGATGGCTACTACTGAAGTTGTCT
GTCTACTTGGGATAATAGCAAATTAATTGAAGACAATGGGAAAGTAAGTTATAAAAAATACTGGGAAATCTGTTTCTCTTCTGAGCAAGC
ATTCAGGGCAGGTATAAACATCAAACATAGTGACATTGTCAAAACCTCTTCCATTTGAACATTGATTAATTCATCAAATAAATGGTATAG
TAATAAATTTTGCTTGCAGAAGAATCTGGATGGGAAGTGATAGAATTATAAGGGCTGTTGAGATTGCTTTGCTACAAAGCACTTTTCTGA

>In-frame_ENST00000396209_ENST00000414691_TCGA-DD-AAVR-01A_MGST1_chr12_16510633_+_ADTRP_chr6_11723733_length(amino acids)=147AA_start in transcript=107_stop in transcript=550
MSPCGFQTKIEKMVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRSILWL

--------------------------------------------------------------
>In-frame_ENST00000396207_ENST00000414691_TCGA-DD-AAVR-01A_MGST1_chr12_16510633_+_ADTRP_chr6_11723733_length(transcript)=1435nt_BP=294nt
GAATTCAAGTCCTAAAGCCTACAGTTTTGAATACTACTGAAATGACAAGTTATTCCAGACCAAAATTGAAAAAATGGTTGACCTCACCCA
GGTAATGGATGATGAAGTATTCATGGCTTTTGCATCCTATGCAACAATTATTCTTTCAAAAATGATGCTTATGAGTACTGCAACTGCATT
CTATAGATTGACAAGAAAGGTTTTTGCCAATCCAGAAGACTGTGTAGCATTTGGCAAAGGAGAAAATGCCAAGAAGTATCTTCGAACAGA
TGACAGAGTAGAACGTGTACGCAGCATCCTATGGCTCTACTTTGAGACGGGTACCTGGGTGTATCCTGTGTTTGCCAAACTCAGCCTCTT
GGGTCTAGCAGCTTTCTTCTCTCTCAGCTACGTCTTCATCGCCAGCATCTACCTACTTGGAGAGAAGCTCAACCACTGGAAATGGGGTGA
CATGAGGCAGCCACGGAAGAAGAGGAAGTAATTGCACACCATTTTCCAAGAACCAAGAAAGAAGAAAACACAAGAGATTTTTCTCATCTT
TTTTTTTTTTTTCTGGTGGAGGGAGGTGGTGGAGGAACATAGCAAAGTAGGAGGGACAGAGAGTGATACTTAAATTTAATAAGAGGTTCG
TGAAGGTAGCTTAACTTGAGAACTCTTGGTTTTTTGAAAGGTTGACTGCACATGCCAAAAACAACTCCTGCTATCTCAGAATTAATTATC
TTTGACCTTCGTGGAGGATGGTCTCTGGTTAAAATCTGGCCAAAGAAACTCACATAAACTTGGTGTTAGAGAACATCTAGAGAGAGAGAG
AGGAACTTAGAGTCATTTAAACTCTTCAGTTTACAGAGAAGGATGCTGAGGACCTAGATGAGAAGTTACCTGCAAAAGGCAAAAGGGTTA
CTTAGTGTCAGAACCAAGGCAATGACTTCTCTCTCCCAGATCTCCTAGCTACTGGTCCTGGGCCATTTTTTTTTTTTTAAATAATCCCAA
CTTTCTTTAAAAGACAAGCATTTCAGTAAGCTAGTTATTTTCATGGGTTGCTCATCCATTTTTTTCAGTGATCTAAAAATGTAGGGAGAT
GGCTACTACTGAAGTTGTCTGTCTACTTGGGATAATAGCAAATTAATTGAAGACAATGGGAAAGTAAGTTATAAAAAATACTGGGAAATC
TGTTTCTCTTCTGAGCAAGCATTCAGGGCAGGTATAAACATCAAACATAGTGACATTGTCAAAACCTCTTCCATTTGAACATTGATTAAT
TCATCAAATAAATGGTATAGTAATAAATTTTGCTTGCAGAAGAATCTGGATGGGAAGTGATAGAATTATAAGGGCTGTTGAGATTGCTTT

>In-frame_ENST00000396207_ENST00000414691_TCGA-DD-AAVR-01A_MGST1_chr12_16510633_+_ADTRP_chr6_11723733_length(amino acids)=135AA_start in transcript=73_stop in transcript=480
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRSILWLYFETGTWVYPVF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MGST1-ADTRP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MGST1-ADTRP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMGST1P10620DB03310Glutathione disulfideActivatorSmall moleculeApproved|Experimental|Investigational
HgeneMGST1P10620DB03310Glutathione disulfideActivatorSmall moleculeApproved|Experimental|Investigational
HgeneMGST1P10620DB03310Glutathione disulfideActivatorSmall moleculeApproved|Experimental|Investigational
HgeneMGST1P10620DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical
HgeneMGST1P10620DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical
HgeneMGST1P10620DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical

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Related Diseases for MGST1-ADTRP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMGST1C0270715Degenerative Diseases, Central Nervous System1CTD_human
HgeneMGST1C0524851Neurodegenerative Disorders1CTD_human
HgeneMGST1C0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneADTRPC0010054Coronary Arteriosclerosis1CTD_human
TgeneADTRPC1956346Coronary Artery Disease1CTD_human