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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MICALL1-SHC1 (FusionGDB2 ID:53228)

Fusion Gene Summary for MICALL1-SHC1

check button Fusion gene summary
Fusion gene informationFusion gene name: MICALL1-SHC1
Fusion gene ID: 53228
HgeneTgene
Gene symbol

MICALL1

SHC1

Gene ID

85377

6464

Gene nameMICAL like 1SHC adaptor protein 1
SynonymsMICAL-L1|MIRAB13SHC|SHCA
Cytomap

22q13.1

1q21.3

Type of geneprotein-codingprotein-coding
DescriptionMICAL-like protein 1molecule interacting with Rab13SHC-transforming protein 1SH2 domain protein C1SHC (Src homology 2 domain containing) transforming protein 1SHC-transforming protein 3SHC-transforming protein A
Modification date2020031320200327
UniProtAcc

Q8N3F8

.
Ensembl transtripts involved in fusion geneENST00000215957, ENST00000402631, 
ENST00000368445, ENST00000368449, 
ENST00000448116, ENST00000368450, 
ENST00000368453, ENST00000606391, 
ENST00000490667, 
Fusion gene scores* DoF score10 X 11 X 8=88011 X 4 X 8=352
# samples 1310
** MAII scorelog2(13/880*10)=-2.75899190049621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/352*10)=-1.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MICALL1 [Title/Abstract] AND SHC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMICALL1(38302575)-SHC1(154938993), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMICALL1

GO:0097320

plasma membrane tubulation

23596323

TgeneSHC1

GO:0000165

MAPK cascade

14676841

TgeneSHC1

GO:0000187

activation of MAPK activity

14676841

TgeneSHC1

GO:0071363

cellular response to growth factor stimulus

20010870


check buttonFusion gene breakpoints across MICALL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SHC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-PG-A914-01AMICALL1chr22

38302575

+SHC1chr1

154938993

-
ChimerDB4UCECTCGA-PG-A914MICALL1chr22

38302575

+SHC1chr1

154938993

-
ChimerDB4UCECTCGA-PG-A914MICALL1chr22

38302575

+SHC1chr1

154938993

-
ChimerDB4UCECTCGA-PG-A914-01AMICALL1chr22

38302575

-SHC1chr1

154938993

-


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Fusion Gene ORF analysis for MICALL1-SHC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000215957ENST00000368445MICALL1chr22

38302575

+SHC1chr1

154938993

-
In-frameENST00000215957ENST00000368449MICALL1chr22

38302575

+SHC1chr1

154938993

-
In-frameENST00000215957ENST00000448116MICALL1chr22

38302575

+SHC1chr1

154938993

-
In-frameENST00000215957ENST00000368450MICALL1chr22

38302575

+SHC1chr1

154938993

-
In-frameENST00000215957ENST00000368453MICALL1chr22

38302575

+SHC1chr1

154938993

-
In-frameENST00000215957ENST00000606391MICALL1chr22

38302575

+SHC1chr1

154938993

-
5CDS-intronENST00000215957ENST00000490667MICALL1chr22

38302575

+SHC1chr1

154938993

-
intron-3CDSENST00000402631ENST00000368445MICALL1chr22

38302575

+SHC1chr1

154938993

-
intron-3CDSENST00000402631ENST00000368449MICALL1chr22

38302575

+SHC1chr1

154938993

-
intron-3CDSENST00000402631ENST00000448116MICALL1chr22

38302575

+SHC1chr1

154938993

-
intron-3CDSENST00000402631ENST00000368450MICALL1chr22

38302575

+SHC1chr1

154938993

-
intron-3CDSENST00000402631ENST00000368453MICALL1chr22

38302575

+SHC1chr1

154938993

-
intron-3CDSENST00000402631ENST00000606391MICALL1chr22

38302575

+SHC1chr1

154938993

-
intron-intronENST00000402631ENST00000490667MICALL1chr22

38302575

+SHC1chr1

154938993

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000215957MICALL1chr2238302575+ENST00000368445SHC1chr1154938993-25462721261040304
ENST00000215957MICALL1chr2238302575+ENST00000368449SHC1chr1154938993-25462721261040304
ENST00000215957MICALL1chr2238302575+ENST00000448116SHC1chr1154938993-25492721261043305
ENST00000215957MICALL1chr2238302575+ENST00000368450SHC1chr1154938993-25462721261040304
ENST00000215957MICALL1chr2238302575+ENST00000368453SHC1chr1154938993-25492721261043305
ENST00000215957MICALL1chr2238302575+ENST00000606391SHC1chr1154938993-25452721261040304

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000215957ENST00000368445MICALL1chr2238302575+SHC1chr1154938993-0.0314420.96855795
ENST00000215957ENST00000368449MICALL1chr2238302575+SHC1chr1154938993-0.0314420.96855795
ENST00000215957ENST00000448116MICALL1chr2238302575+SHC1chr1154938993-0.0338184130.9661816
ENST00000215957ENST00000368450MICALL1chr2238302575+SHC1chr1154938993-0.0314420.96855795
ENST00000215957ENST00000368453MICALL1chr2238302575+SHC1chr1154938993-0.0338184130.9661816
ENST00000215957ENST00000606391MICALL1chr2238302575+SHC1chr1154938993-0.031448390.9685516

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Fusion Genomic Features for MICALL1-SHC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MICALL1-SHC1


check button Go to

FGviewer for the breakpoints of chr22:38302575-chr1:154938993

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICALL1

Q8N3F8

.
FUNCTION: Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth. {ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSHC1chr22:38302575chr1:154938993ENST00000368445612411_474327.6666666666667584.0Compositional biasNote=Pro-rich
TgeneSHC1chr22:38302575chr1:154938993ENST00000368450713411_474217.66666666666666474.0Compositional biasNote=Pro-rich
TgeneSHC1chr22:38302575chr1:154938993ENST00000368453713411_474217.66666666666666475.0Compositional biasNote=Pro-rich
TgeneSHC1chr22:38302575chr1:154938993ENST00000448116612411_474327.6666666666667585.0Compositional biasNote=Pro-rich
TgeneSHC1chr22:38302575chr1:154938993ENST00000368445612488_579327.6666666666667584.0DomainSH2
TgeneSHC1chr22:38302575chr1:154938993ENST00000368450713488_579217.66666666666666474.0DomainSH2
TgeneSHC1chr22:38302575chr1:154938993ENST00000368453713488_579217.66666666666666475.0DomainSH2
TgeneSHC1chr22:38302575chr1:154938993ENST00000448116612488_579327.6666666666667585.0DomainSH2
TgeneSHC1chr22:38302575chr1:154938993ENST00000368445612340_487327.6666666666667584.0RegionNote=CH1
TgeneSHC1chr22:38302575chr1:154938993ENST00000368450713340_487217.66666666666666474.0RegionNote=CH1
TgeneSHC1chr22:38302575chr1:154938993ENST00000368453713340_487217.66666666666666475.0RegionNote=CH1
TgeneSHC1chr22:38302575chr1:154938993ENST00000448116612340_487327.6666666666667585.0RegionNote=CH1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICALL1chr22:38302575chr1:154938993ENST00000215957+116682_71148.666666666666664864.0Coiled coilOntology_term=ECO:0000255
HgeneMICALL1chr22:38302575chr1:154938993ENST00000215957+116785_83048.666666666666664864.0Coiled coilOntology_term=ECO:0000255
HgeneMICALL1chr22:38302575chr1:154938993ENST00000215957+116253_66748.666666666666664864.0Compositional biasNote=Pro-rich
HgeneMICALL1chr22:38302575chr1:154938993ENST00000215957+116162_22548.666666666666664864.0DomainLIM zinc-binding
HgeneMICALL1chr22:38302575chr1:154938993ENST00000215957+1162_10848.666666666666664864.0DomainCalponin-homology (CH)
HgeneMICALL1chr22:38302575chr1:154938993ENST00000215957+116671_81848.666666666666664864.0DomainbMERB
HgeneMICALL1chr22:38302575chr1:154938993ENST00000215957+116700_86348.666666666666664864.0RegionNote=Necessary and sufficient to associate with tubular recycling endosome membranes%2C mediate phosphatidic acid-binding and membrane tubulation
TgeneSHC1chr22:38302575chr1:154938993ENST00000368445612156_339327.6666666666667584.0DomainPID
TgeneSHC1chr22:38302575chr1:154938993ENST00000368450713156_339217.66666666666666474.0DomainPID
TgeneSHC1chr22:38302575chr1:154938993ENST00000368453713156_339217.66666666666666475.0DomainPID
TgeneSHC1chr22:38302575chr1:154938993ENST00000448116612156_339327.6666666666667585.0DomainPID


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Fusion Gene Sequence for MICALL1-SHC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000215957_ENST00000368445_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(transcript)=2546nt_BP=272nt
GCCTGCCGGTCGGCGCCCGAGCTCGGAGCCGCAGCCGCAGCCGGAAACCGGGCCCGCGCGGCGGCCGCCGTCCCGGCCAAGCCGGGGCCC
CGAAGCCAGAGCCGGAGCCGGGCGGGCCGCGGGGTCATGGCTGGGCCGCGGGGCGCGCTGCTGGCCTGGTGCCGCCGCCAGTGCGAGGGC
TACCGCGGCGTGGAGATCCGCGACCTGAGCAGCTCCTTCCGGGACGGCCTGGCCTTCTGCGCCATCCTGCACCGGCACCGGCCCGACCTG
CTGATGGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAA
CCCCCCTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCC
AGCCACTTGGGAGCTACATTGCCTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCA
GGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCCAAT
CCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTCCCCAGTCGGTG
TCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCTCAATGGGGAC
TTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCTACTGGTGGAC
CCTGAGGGTGTGGTTCGGACTAAGGATCACCGCTTTGAAAGTGTCAGTCACCTTATCAGCTACCACATGGACAATCACTTGCCCATCATC
TCTGCGGGCAGCGAACTGTGTCTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCAATC
CTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGACTC
TGGGTTTCATATCCAGCTGAGTGAGAGGGTTTGAGTCAAAAGCCTGGGTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGTATT
AATGTACAGAGTGGCCCCTCACCTGGGCCTTTCCTGTGCCAACCTGATGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAATGTC
CTGTGGTGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCTGGGCTTCAGGGTATCCCAGACCCCTCT
CAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTCTTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCCCTG
AATTCAATGACAGGGATGCCAACACCTTCTTGGCTTCTGGGACCTGTGTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAACAGA
GGCAGGAGTGGCAGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTAGAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGATGGA
CCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATACATTTCATAAGGCCTGCCCTCCCATGTTGCA
TGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCTGAAGCCTCTGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGACTGA
ATTTGGGCCTCTTGTACAGTTAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAATCCC
CACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATATGCATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTCTTT
TCCATTGCTTATTCTTGAGCACAAAATGATAATCAATTATTACATTTATACATCACCTTTTTGACTTTTCCAAGCCCTTTTACAGCTCTT
GGCATTTTCCTCGCCTAGGCCTGTGAGGTAACTGGGATCGCACCTTTTATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCTAGG
ACTAGAAAAACTTGGGTCTCTTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAAACC
TGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGGGGTGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGCCTT
GTGGATAAGGGAGAGTTGACCGTTTTCATCCTGGCCTCCTTTTGCTGTTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAAACT

>In-frame_ENST00000215957_ENST00000368445_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(amino acids)=304AA_start in transcript=126_stop in transcript=1040
MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLR
EGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLF
DMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRF

--------------------------------------------------------------
>In-frame_ENST00000215957_ENST00000368449_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(transcript)=2546nt_BP=272nt
GCCTGCCGGTCGGCGCCCGAGCTCGGAGCCGCAGCCGCAGCCGGAAACCGGGCCCGCGCGGCGGCCGCCGTCCCGGCCAAGCCGGGGCCC
CGAAGCCAGAGCCGGAGCCGGGCGGGCCGCGGGGTCATGGCTGGGCCGCGGGGCGCGCTGCTGGCCTGGTGCCGCCGCCAGTGCGAGGGC
TACCGCGGCGTGGAGATCCGCGACCTGAGCAGCTCCTTCCGGGACGGCCTGGCCTTCTGCGCCATCCTGCACCGGCACCGGCCCGACCTG
CTGATGGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAA
CCCCCCTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCC
AGCCACTTGGGAGCTACATTGCCTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCA
GGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCCAAT
CCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTCCCCAGTCGGTG
TCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCTCAATGGGGAC
TTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCTACTGGTGGAC
CCTGAGGGTGTGGTTCGGACTAAGGATCACCGCTTTGAAAGTGTCAGTCACCTTATCAGCTACCACATGGACAATCACTTGCCCATCATC
TCTGCGGGCAGCGAACTGTGTCTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCAATC
CTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGACTC
TGGGTTTCATATCCAGCTGAGTGAGAGGGTTTGAGTCAAAAGCCTGGGTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGTATT
AATGTACAGAGTGGCCCCTCACCTGGGCCTTTCCTGTGCCAACCTGATGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAATGTC
CTGTGGTGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCTGGGCTTCAGGGTATCCCAGACCCCTCT
CAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTCTTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCCCTG
AATTCAATGACAGGGATGCCAACACCTTCTTGGCTTCTGGGACCTGTGTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAACAGA
GGCAGGAGTGGCAGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTAGAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGATGGA
CCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATACATTTCATAAGGCCTGCCCTCCCATGTTGCA
TGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCTGAAGCCTCTGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGACTGA
ATTTGGGCCTCTTGTACAGTTAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAATCCC
CACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATATGCATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTCTTT
TCCATTGCTTATTCTTGAGCACAAAATGATAATCAATTATTACATTTATACATCACCTTTTTGACTTTTCCAAGCCCTTTTACAGCTCTT
GGCATTTTCCTCGCCTAGGCCTGTGAGGTAACTGGGATCGCACCTTTTATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCTAGG
ACTAGAAAAACTTGGGTCTCTTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAAACC
TGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGGGGTGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGCCTT
GTGGATAAGGGAGAGTTGACCGTTTTCATCCTGGCCTCCTTTTGCTGTTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAAACT

>In-frame_ENST00000215957_ENST00000368449_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(amino acids)=304AA_start in transcript=126_stop in transcript=1040
MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLR
EGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLF
DMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRF

--------------------------------------------------------------
>In-frame_ENST00000215957_ENST00000448116_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(transcript)=2549nt_BP=272nt
GCCTGCCGGTCGGCGCCCGAGCTCGGAGCCGCAGCCGCAGCCGGAAACCGGGCCCGCGCGGCGGCCGCCGTCCCGGCCAAGCCGGGGCCC
CGAAGCCAGAGCCGGAGCCGGGCGGGCCGCGGGGTCATGGCTGGGCCGCGGGGCGCGCTGCTGGCCTGGTGCCGCCGCCAGTGCGAGGGC
TACCGCGGCGTGGAGATCCGCGACCTGAGCAGCTCCTTCCGGGACGGCCTGGCCTTCTGCGCCATCCTGCACCGGCACCGGCCCGACCTG
CTGATGGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAA
CCCCCCTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCC
AGCCACTTGGGAGCTACATTGCCTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCA
GCAGGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCC
AATCCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTCCCCAGTCG
GTGTCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCTCAATGGG
GACTTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCTACTGGTG
GACCCTGAGGGTGTGGTTCGGACTAAGGATCACCGCTTTGAAAGTGTCAGTCACCTTATCAGCTACCACATGGACAATCACTTGCCCATC
ATCTCTGCGGGCAGCGAACTGTGTCTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCA
ATCCTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGA
CTCTGGGTTTCATATCCAGCTGAGTGAGAGGGTTTGAGTCAAAAGCCTGGGTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGT
ATTAATGTACAGAGTGGCCCCTCACCTGGGCCTTTCCTGTGCCAACCTGATGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAAT
GTCCTGTGGTGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCTGGGCTTCAGGGTATCCCAGACCCC
TCTCAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTCTTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCC
CTGAATTCAATGACAGGGATGCCAACACCTTCTTGGCTTCTGGGACCTGTGTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAAC
AGAGGCAGGAGTGGCAGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTAGAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGAT
GGACCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATACATTTCATAAGGCCTGCCCTCCCATGTT
GCATGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCTGAAGCCTCTGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGAC
TGAATTTGGGCCTCTTGTACAGTTAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAAT
CCCCACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATATGCATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTC
TTTTCCATTGCTTATTCTTGAGCACAAAATGATAATCAATTATTACATTTATACATCACCTTTTTGACTTTTCCAAGCCCTTTTACAGCT
CTTGGCATTTTCCTCGCCTAGGCCTGTGAGGTAACTGGGATCGCACCTTTTATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCT
AGGACTAGAAAAACTTGGGTCTCTTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAA
ACCTGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGGGGTGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGC
CTTGTGGATAAGGGAGAGTTGACCGTTTTCATCCTGGCCTCCTTTTGCTGTTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAA

>In-frame_ENST00000215957_ENST00000448116_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(amino acids)=305AA_start in transcript=126_stop in transcript=1043
MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLR
EGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDL
FDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHR

--------------------------------------------------------------
>In-frame_ENST00000215957_ENST00000368450_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(transcript)=2546nt_BP=272nt
GCCTGCCGGTCGGCGCCCGAGCTCGGAGCCGCAGCCGCAGCCGGAAACCGGGCCCGCGCGGCGGCCGCCGTCCCGGCCAAGCCGGGGCCC
CGAAGCCAGAGCCGGAGCCGGGCGGGCCGCGGGGTCATGGCTGGGCCGCGGGGCGCGCTGCTGGCCTGGTGCCGCCGCCAGTGCGAGGGC
TACCGCGGCGTGGAGATCCGCGACCTGAGCAGCTCCTTCCGGGACGGCCTGGCCTTCTGCGCCATCCTGCACCGGCACCGGCCCGACCTG
CTGATGGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAA
CCCCCCTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCC
AGCCACTTGGGAGCTACATTGCCTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCA
GGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCCAAT
CCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTCCCCAGTCGGTG
TCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCTCAATGGGGAC
TTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCTACTGGTGGAC
CCTGAGGGTGTGGTTCGGACTAAGGATCACCGCTTTGAAAGTGTCAGTCACCTTATCAGCTACCACATGGACAATCACTTGCCCATCATC
TCTGCGGGCAGCGAACTGTGTCTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCAATC
CTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGACTC
TGGGTTTCATATCCAGCTGAGTGAGAGGGTTTGAGTCAAAAGCCTGGGTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGTATT
AATGTACAGAGTGGCCCCTCACCTGGGCCTTTCCTGTGCCAACCTGATGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAATGTC
CTGTGGTGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCTGGGCTTCAGGGTATCCCAGACCCCTCT
CAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTCTTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCCCTG
AATTCAATGACAGGGATGCCAACACCTTCTTGGCTTCTGGGACCTGTGTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAACAGA
GGCAGGAGTGGCAGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTAGAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGATGGA
CCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATACATTTCATAAGGCCTGCCCTCCCATGTTGCA
TGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCTGAAGCCTCTGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGACTGA
ATTTGGGCCTCTTGTACAGTTAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAATCCC
CACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATATGCATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTCTTT
TCCATTGCTTATTCTTGAGCACAAAATGATAATCAATTATTACATTTATACATCACCTTTTTGACTTTTCCAAGCCCTTTTACAGCTCTT
GGCATTTTCCTCGCCTAGGCCTGTGAGGTAACTGGGATCGCACCTTTTATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCTAGG
ACTAGAAAAACTTGGGTCTCTTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAAACC
TGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGGGGTGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGCCTT
GTGGATAAGGGAGAGTTGACCGTTTTCATCCTGGCCTCCTTTTGCTGTTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAAACT

>In-frame_ENST00000215957_ENST00000368450_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(amino acids)=304AA_start in transcript=126_stop in transcript=1040
MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLR
EGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLF
DMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRF

--------------------------------------------------------------
>In-frame_ENST00000215957_ENST00000368453_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(transcript)=2549nt_BP=272nt
GCCTGCCGGTCGGCGCCCGAGCTCGGAGCCGCAGCCGCAGCCGGAAACCGGGCCCGCGCGGCGGCCGCCGTCCCGGCCAAGCCGGGGCCC
CGAAGCCAGAGCCGGAGCCGGGCGGGCCGCGGGGTCATGGCTGGGCCGCGGGGCGCGCTGCTGGCCTGGTGCCGCCGCCAGTGCGAGGGC
TACCGCGGCGTGGAGATCCGCGACCTGAGCAGCTCCTTCCGGGACGGCCTGGCCTTCTGCGCCATCCTGCACCGGCACCGGCCCGACCTG
CTGATGGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAA
CCCCCCTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCC
AGCCACTTGGGAGCTACATTGCCTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCA
GCAGGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCC
AATCCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTCCCCAGTCG
GTGTCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCTCAATGGG
GACTTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCTACTGGTG
GACCCTGAGGGTGTGGTTCGGACTAAGGATCACCGCTTTGAAAGTGTCAGTCACCTTATCAGCTACCACATGGACAATCACTTGCCCATC
ATCTCTGCGGGCAGCGAACTGTGTCTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCA
ATCCTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGA
CTCTGGGTTTCATATCCAGCTGAGTGAGAGGGTTTGAGTCAAAAGCCTGGGTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGT
ATTAATGTACAGAGTGGCCCCTCACCTGGGCCTTTCCTGTGCCAACCTGATGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAAT
GTCCTGTGGTGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCTGGGCTTCAGGGTATCCCAGACCCC
TCTCAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTCTTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCC
CTGAATTCAATGACAGGGATGCCAACACCTTCTTGGCTTCTGGGACCTGTGTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAAC
AGAGGCAGGAGTGGCAGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTAGAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGAT
GGACCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATACATTTCATAAGGCCTGCCCTCCCATGTT
GCATGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCTGAAGCCTCTGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGAC
TGAATTTGGGCCTCTTGTACAGTTAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAAT
CCCCACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATATGCATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTC
TTTTCCATTGCTTATTCTTGAGCACAAAATGATAATCAATTATTACATTTATACATCACCTTTTTGACTTTTCCAAGCCCTTTTACAGCT
CTTGGCATTTTCCTCGCCTAGGCCTGTGAGGTAACTGGGATCGCACCTTTTATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCT
AGGACTAGAAAAACTTGGGTCTCTTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAA
ACCTGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGGGGTGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGC
CTTGTGGATAAGGGAGAGTTGACCGTTTTCATCCTGGCCTCCTTTTGCTGTTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAA

>In-frame_ENST00000215957_ENST00000368453_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(amino acids)=305AA_start in transcript=126_stop in transcript=1043
MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLR
EGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDL
FDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHR

--------------------------------------------------------------
>In-frame_ENST00000215957_ENST00000606391_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(transcript)=2545nt_BP=272nt
GCCTGCCGGTCGGCGCCCGAGCTCGGAGCCGCAGCCGCAGCCGGAAACCGGGCCCGCGCGGCGGCCGCCGTCCCGGCCAAGCCGGGGCCC
CGAAGCCAGAGCCGGAGCCGGGCGGGCCGCGGGGTCATGGCTGGGCCGCGGGGCGCGCTGCTGGCCTGGTGCCGCCGCCAGTGCGAGGGC
TACCGCGGCGTGGAGATCCGCGACCTGAGCAGCTCCTTCCGGGACGGCCTGGCCTTCTGCGCCATCCTGCACCGGCACCGGCCCGACCTG
CTGATGGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAA
CCCCCCTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCC
AGCCACTTGGGAGCTACATTGCCTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCA
GGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCCAAT
CCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTCCCCAGTCGGTG
TCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCTCAATGGGGAC
TTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCTACTGGTGGAC
CCTGAGGGTGTGGTTCGGACTAAGGATCACCGCTTTGAAAGTGTCAGTCACCTTATCAGCTACCACATGGACAATCACTTGCCCATCATC
TCTGCGGGCAGCGAACTGTGTCTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCAATC
CTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGACTC
TGGGTTTCATATCCAGCTGAGTGAGAGGGTTTGAGTCAAAAGCCTGGGTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGTATT
AATGTACAGAGTGGCCCCTCACCTGGGCCTTTCCTGTGCCAACCTGATGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAATGTC
CTGTGGTGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCTGGGCTTCAGGGTATCCCAGACCCCTCT
CAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTCTTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCCCTG
AATTCAATGACAGGGATGCCAACACCTTCTTGGCTTCTGGGACCTGTGTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAACAGA
GGCAGGAGTGGCAGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTAGAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGATGGA
CCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATACATTTCATAAGGCCTGCCCTCCCATGTTGCA
TGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCTGAAGCCTCTGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGACTGA
ATTTGGGCCTCTTGTACAGTTAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAATCCC
CACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATATGCATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTCTTT
TCCATTGCTTATTCTTGAGCACAAAATGATAATCAATTATTACATTTATACATCACCTTTTTGACTTTTCCAAGCCCTTTTACAGCTCTT
GGCATTTTCCTCGCCTAGGCCTGTGAGGTAACTGGGATCGCACCTTTTATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCTAGG
ACTAGAAAAACTTGGGTCTCTTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAAACC
TGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGGGGTGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGCCTT
GTGGATAAGGGAGAGTTGACCGTTTTCATCCTGGCCTCCTTTTGCTGTTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAAACT

>In-frame_ENST00000215957_ENST00000606391_TCGA-PG-A914-01A_MICALL1_chr22_38302575_+_SHC1_chr1_154938993_length(amino acids)=304AA_start in transcript=126_stop in transcript=1040
MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLR
EGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLF
DMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MICALL1-SHC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MICALL1-SHC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MICALL1-SHC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSHC1C0018800Cardiomegaly1CTD_human
TgeneSHC1C0019193Hepatitis, Toxic1CTD_human
TgeneSHC1C0860207Drug-Induced Liver Disease1CTD_human
TgeneSHC1C1262760Hepatitis, Drug-Induced1CTD_human
TgeneSHC1C1383860Cardiac Hypertrophy1CTD_human
TgeneSHC1C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneSHC1C1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneSHC1C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneSHC1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneSHC1C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneSHC1C4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human