FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MICALL2-PPP1R1B (FusionGDB2 ID:53236)

Fusion Gene Summary for MICALL2-PPP1R1B

check button Fusion gene summary
Fusion gene informationFusion gene name: MICALL2-PPP1R1B
Fusion gene ID: 53236
HgeneTgene
Gene symbol

MICALL2

PPP1R1B

Gene ID

79778

84152

Gene nameMICAL like 2protein phosphatase 1 regulatory inhibitor subunit 1B
SynonymsJRAB|MICAL-L2DARPP-32|DARPP32
Cytomap

7p22.3

17q12

Type of geneprotein-codingprotein-coding
DescriptionMICAL-like protein 2junctional Rab13-binding proteinmolecule interacting with CasL-like 2protein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32
Modification date2020031320200313
UniProtAcc

Q8IY33

.
Ensembl transtripts involved in fusion geneENST00000405088, ENST00000471899, 
ENST00000297508, 		ENST00000580825, 
ENST00000254079, ENST00000579000, 
ENST00000394265, ENST00000394267, 
Fusion gene scores* DoF score12 X 8 X 8=76817 X 10 X 9=1530
# samples 1626
** MAII scorelog2(16/768*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/1530*10)=-2.55694812455156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MICALL2 [Title/Abstract] AND PPP1R1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMICALL2(1489876)-PPP1R1B(37785423), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP1R1B

GO:0032515

negative regulation of phosphoprotein phosphatase activity

10807923


check buttonFusion gene breakpoints across MICALL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PPP1R1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8080-01AMICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+


Top

Fusion Gene ORF analysis for MICALL2-PPP1R1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000405088ENST00000580825MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
intron-3CDSENST00000405088ENST00000254079MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
intron-3CDSENST00000405088ENST00000579000MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
intron-5UTRENST00000405088ENST00000394265MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
intron-5UTRENST00000405088ENST00000394267MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
intron-3CDSENST00000471899ENST00000580825MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
intron-3CDSENST00000471899ENST00000254079MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
intron-3CDSENST00000471899ENST00000579000MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
intron-5UTRENST00000471899ENST00000394265MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
intron-5UTRENST00000471899ENST00000394267MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
In-frameENST00000297508ENST00000580825MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
In-frameENST00000297508ENST00000254079MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
In-frameENST00000297508ENST00000579000MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
5CDS-5UTRENST00000297508ENST00000394265MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+
5CDS-5UTRENST00000297508ENST00000394267MICALL2chr7

1489876

-PPP1R1Bchr17

37785423

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297508MICALL2chr71489876-ENST00000580825PPP1R1Bchr1737785423+103736892901269
ENST00000297508MICALL2chr71489876-ENST00000254079PPP1R1Bchr1737785423+166336892901269
ENST00000297508MICALL2chr71489876-ENST00000579000PPP1R1Bchr1737785423+156036892802236

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297508ENST00000580825MICALL2chr71489876-PPP1R1Bchr1737785423+0.0116304120.9883696
ENST00000297508ENST00000254079MICALL2chr71489876-PPP1R1Bchr1737785423+0.0075347260.99246526
ENST00000297508ENST00000579000MICALL2chr71489876-PPP1R1Bchr1737785423+0.0045525160.99544746

Top

Fusion Genomic Features for MICALL2-PPP1R1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MICALL2-PPP1R1B


check button Go to

FGviewer for the breakpoints of chr7:1489876-chr17:37785423

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICALL2

Q8IY33

.
FUNCTION: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPP1R1Bchr7:1489876chr17:37785423ENST0000025407907119_13627.0205.0Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr7:1489876chr17:37785423ENST0000039426507119_1360169.0Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr7:1489876chr17:37785423ENST0000039426707119_1360169.0Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr7:1489876chr17:37785423ENST0000058082518119_13627.0205.0Compositional biasNote=Asp/Glu-rich (acidic)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICALL2chr7:1489876chr17:37785423ENST00000297508-217735_77164.0905.0Coiled coilOntology_term=ECO:0000255
HgeneMICALL2chr7:1489876chr17:37785423ENST00000405088-113735_7710.0693.0Coiled coilOntology_term=ECO:0000255
HgeneMICALL2chr7:1489876chr17:37785423ENST00000297508-217356_35964.0905.0Compositional biasNote=Poly-Ala
HgeneMICALL2chr7:1489876chr17:37785423ENST00000297508-217392_39764.0905.0Compositional biasNote=Poly-Ser
HgeneMICALL2chr7:1489876chr17:37785423ENST00000297508-217663_66664.0905.0Compositional biasNote=Poly-Arg
HgeneMICALL2chr7:1489876chr17:37785423ENST00000405088-113356_3590.0693.0Compositional biasNote=Poly-Ala
HgeneMICALL2chr7:1489876chr17:37785423ENST00000405088-113392_3970.0693.0Compositional biasNote=Poly-Ser
HgeneMICALL2chr7:1489876chr17:37785423ENST00000405088-113663_6660.0693.0Compositional biasNote=Poly-Arg
HgeneMICALL2chr7:1489876chr17:37785423ENST00000297508-217186_24864.0905.0DomainLIM zinc-binding
HgeneMICALL2chr7:1489876chr17:37785423ENST00000297508-2171_10764.0905.0DomainCalponin-homology (CH)
HgeneMICALL2chr7:1489876chr17:37785423ENST00000297508-217723_87464.0905.0DomainbMERB
HgeneMICALL2chr7:1489876chr17:37785423ENST00000405088-113186_2480.0693.0DomainLIM zinc-binding
HgeneMICALL2chr7:1489876chr17:37785423ENST00000405088-1131_1070.0693.0DomainCalponin-homology (CH)
HgeneMICALL2chr7:1489876chr17:37785423ENST00000405088-113723_8740.0693.0DomainbMERB
HgeneMICALL2chr7:1489876chr17:37785423ENST00000297508-217261_69764.0905.0RegionMediates targeting to the cell plasma membrane
HgeneMICALL2chr7:1489876chr17:37785423ENST00000405088-113261_6970.0693.0RegionMediates targeting to the cell plasma membrane


Top

Fusion Gene Sequence for MICALL2-PPP1R1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000297508_ENST00000580825_TCGA-BR-8080-01A_MICALL2_chr7_1489876_-_PPP1R1B_chr17_37785423_length(transcript)=1037nt_BP=368nt
CTTCTCTTAGGGACCCGGCACTCGTCGCCCTCAGTCCGGCTCAGCTGGGGCTGGGCGCCGTGGGTCTGGCGGTTCCGTAGCGGTCCCAGC
GTCTGTCCCGCCGGCCGGGCGGTCGCGGCACAGCCGCGGGAAGGTGTCGGAGGGCGGTTCCGCCGCGCGGCGGGCGCGCCGCCCACATGG
CGGCCATCAGGGCGCTGCAACAGTGGTGCCGGCAGCAGTGCGAGGGCTACCGCGACGTGAATATCTGCAACATGACCACGTCGTTCCGCG
ACGGCCTGGCTTTCTGCGCCATCCTGCACCGCCACCGGCCCGACCTCATAAACTTCAGTGCTCTCAAGAAGGAAAATATTTATGAAAACA
ATAAACTGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACC
AGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCA
TTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGG
GTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCA
TCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAG
ATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACAT
AGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCT

>In-frame_ENST00000297508_ENST00000580825_TCGA-BR-8080-01A_MICALL2_chr7_1489876_-_PPP1R1B_chr17_37785423_length(amino acids)=269AA_start in transcript=92_stop in transcript=901
MSRRPGGRGTAAGRCRRAVPPRGGRAAHMAAIRALQQWCRQQCEGYRDVNICNMTTSFRDGLAFCAILHRHRPDLINFSALKKENIYENN
KLIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELG

--------------------------------------------------------------
>In-frame_ENST00000297508_ENST00000254079_TCGA-BR-8080-01A_MICALL2_chr7_1489876_-_PPP1R1B_chr17_37785423_length(transcript)=1663nt_BP=368nt
CTTCTCTTAGGGACCCGGCACTCGTCGCCCTCAGTCCGGCTCAGCTGGGGCTGGGCGCCGTGGGTCTGGCGGTTCCGTAGCGGTCCCAGC
GTCTGTCCCGCCGGCCGGGCGGTCGCGGCACAGCCGCGGGAAGGTGTCGGAGGGCGGTTCCGCCGCGCGGCGGGCGCGCCGCCCACATGG
CGGCCATCAGGGCGCTGCAACAGTGGTGCCGGCAGCAGTGCGAGGGCTACCGCGACGTGAATATCTGCAACATGACCACGTCGTTCCGCG
ACGGCCTGGCTTTCTGCGCCATCCTGCACCGCCACCGGCCCGACCTCATAAACTTCAGTGCTCTCAAGAAGGAAAATATTTATGAAAACA
ATAAACTGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACC
AGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCA
TTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGG
GTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCA
TCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAG
ATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACAT
AGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCT
TCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGGCTGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCTGATACCC
AGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCATTCACCCAGCGGGAGGTGGGATGTGAGACAGCCCACA
TTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCTACTCCCCAGATCCTCTCCCCTGGACACAGGAGACCCACAGGG
CAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAGATCCTTTTCTACCCACTTTCCTATGGAGGATTCCAA
GTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGTTTTTCTCCATAGCCTCAACATTTTGGGAATCTTCCCTTAATC
ACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTGCGTTTTGTGCTTTGATGCCAGGAATGCCGCCTAGTT
TATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTCCCCCAGCTGCTCTGCCCCTTTCCCCTTCTTCCCTGACTCCAG

>In-frame_ENST00000297508_ENST00000254079_TCGA-BR-8080-01A_MICALL2_chr7_1489876_-_PPP1R1B_chr17_37785423_length(amino acids)=269AA_start in transcript=92_stop in transcript=901
MSRRPGGRGTAAGRCRRAVPPRGGRAAHMAAIRALQQWCRQQCEGYRDVNICNMTTSFRDGLAFCAILHRHRPDLINFSALKKENIYENN
KLIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELG

--------------------------------------------------------------
>In-frame_ENST00000297508_ENST00000579000_TCGA-BR-8080-01A_MICALL2_chr7_1489876_-_PPP1R1B_chr17_37785423_length(transcript)=1560nt_BP=368nt
CTTCTCTTAGGGACCCGGCACTCGTCGCCCTCAGTCCGGCTCAGCTGGGGCTGGGCGCCGTGGGTCTGGCGGTTCCGTAGCGGTCCCAGC
GTCTGTCCCGCCGGCCGGGCGGTCGCGGCACAGCCGCGGGAAGGTGTCGGAGGGCGGTTCCGCCGCGCGGCGGGCGCGCCGCCCACATGG
CGGCCATCAGGGCGCTGCAACAGTGGTGCCGGCAGCAGTGCGAGGGCTACCGCGACGTGAATATCTGCAACATGACCACGTCGTTCCGCG
ACGGCCTGGCTTTCTGCGCCATCCTGCACCGCCACCGGCCCGACCTCATAAACTTCAGTGCTCTCAAGAAGGAAAATATTTATGAAAACA
ATAAACTGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGCTGTGCAGCGCATTGCTGAGT
CTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAA
GAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGT
CTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCT
CTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCA
GCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGC
CTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGGCTGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCTGATACCCAGAGAACCT
GGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCATTCACCCAGCGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAAT
CCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCTACTCCCCAGATCCTCTCCCCTGGACACAGGAGACCCACAGGGCAGGACCCT
AAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAGATCCTTTTCTACCCACTTTCCTATGGAGGATTCCAAGTCACCACT
TCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGTTTTTCTCCATAGCCTCAACATTTTGGGAATCTTCCCTTAATCACCCTTGCT
CCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTGCGTTTTGTGCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCC
GGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTCCCCCAGCTGCTCTGCCCCTTTCCCCTTCTTCCCTGACTCCAGGCCTGAACC

>In-frame_ENST00000297508_ENST00000579000_TCGA-BR-8080-01A_MICALL2_chr7_1489876_-_PPP1R1B_chr17_37785423_length(amino acids)=236AA_start in transcript=92_stop in transcript=802
MSRRPGGRGTAAGRCRRAVPPRGGRAAHMAAIRALQQWCRQQCEGYRDVNICNMTTSFRDGLAFCAILHRHRPDLINFSALKKENIYENN
KLIRRRRPTPAMLFRLSEHSSPAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MICALL2-PPP1R1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MICALL2-PPP1R1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MICALL2-PPP1R1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePPP1R1BC0036341Schizophrenia5PSYGENET
TgenePPP1R1BC0005586Bipolar Disorder4PSYGENET
TgenePPP1R1BC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgenePPP1R1BC0007370Catalepsy1CTD_human
TgenePPP1R1BC0011570Mental Depression1PSYGENET
TgenePPP1R1BC0011581Depressive disorder1PSYGENET
TgenePPP1R1BC0013384Dyskinetic syndrome1CTD_human
TgenePPP1R1BC0152115Lingual-Facial-Buccal Dyskinesia1CTD_human
TgenePPP1R1BC0221169Hemiballismus1CTD_human
TgenePPP1R1BC0232766Asterixis1CTD_human
TgenePPP1R1BC0233612Waxy flexibility1CTD_human
TgenePPP1R1BC0427086Involuntary Movements1CTD_human
TgenePPP1R1BC0454606Oral Dyskinesia1CTD_human
TgenePPP1R1BC0752196Ballismus1CTD_human