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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MID1-PRDX4 (FusionGDB2 ID:53276)

Fusion Gene Summary for MID1-PRDX4

check button Fusion gene summary
Fusion gene informationFusion gene name: MID1-PRDX4
Fusion gene ID: 53276
HgeneTgene
Gene symbol

MID1

PRDX4

Gene ID

4281

10549

Gene namemidline 1peroxiredoxin 4
SynonymsBBBG1|FXY|GBBB1|MIDIN|OGS1|OS|OSX|RNF59|TRIM18|XPRF|ZNFXYAOE37-2|AOE372|HEL-S-97n|PRX-4
Cytomap

Xp22.2

Xp22.11

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Midline-1Opitz/BBB syndromeRING finger protein 59RING finger protein Midline-1RING-type E3 ubiquitin transferase Midline-1midline 1 RING finger proteinputative transcription factor XPRFtripartite motif protein TRIM18triperoxiredoxin-4antioxidant enzyme AOE372epididymis secretory sperm binding protein Li 97nperoxiredoxin IVprx-IVthioredoxin peroxidase (antioxidant enzyme)thioredoxin peroxidase AO372thioredoxin-dependent peroxide reductase A0372
Modification date2020031320200313
UniProtAcc

O15344

.
Ensembl transtripts involved in fusion geneENST00000317552, ENST00000453318, 
ENST00000380779, ENST00000380780, 
ENST00000380785, ENST00000380787, 
ENST00000380782, ENST00000479925, 
ENST00000379341, ENST00000495599, 
ENST00000379331, 
Fusion gene scores* DoF score13 X 10 X 8=10405 X 7 X 3=105
# samples 156
** MAII scorelog2(15/1040*10)=-2.79354912253257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/105*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MID1 [Title/Abstract] AND PRDX4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMID1(10588330)-PRDX4(23700513), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MID1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PRDX4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-7808-01AMID1chrX

10588330

-PRDX4chrX

23700513

+


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Fusion Gene ORF analysis for MID1-PRDX4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000317552ENST00000379341MID1chrX

10588330

-PRDX4chrX

23700513

+
5UTR-intronENST00000317552ENST00000495599MID1chrX

10588330

-PRDX4chrX

23700513

+
5UTR-intronENST00000317552ENST00000379331MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-3CDSENST00000453318ENST00000379341MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-intronENST00000453318ENST00000495599MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-intronENST00000453318ENST00000379331MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-3CDSENST00000380779ENST00000379341MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-intronENST00000380779ENST00000495599MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-intronENST00000380779ENST00000379331MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-3CDSENST00000380780ENST00000379341MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-intronENST00000380780ENST00000495599MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-intronENST00000380780ENST00000379331MID1chrX

10588330

-PRDX4chrX

23700513

+
5UTR-3CDSENST00000380785ENST00000379341MID1chrX

10588330

-PRDX4chrX

23700513

+
5UTR-intronENST00000380785ENST00000495599MID1chrX

10588330

-PRDX4chrX

23700513

+
5UTR-intronENST00000380785ENST00000379331MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-3CDSENST00000380787ENST00000379341MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-intronENST00000380787ENST00000495599MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-intronENST00000380787ENST00000379331MID1chrX

10588330

-PRDX4chrX

23700513

+
5UTR-3CDSENST00000380782ENST00000379341MID1chrX

10588330

-PRDX4chrX

23700513

+
5UTR-intronENST00000380782ENST00000495599MID1chrX

10588330

-PRDX4chrX

23700513

+
5UTR-intronENST00000380782ENST00000379331MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-3CDSENST00000479925ENST00000379341MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-intronENST00000479925ENST00000495599MID1chrX

10588330

-PRDX4chrX

23700513

+
intron-intronENST00000479925ENST00000379331MID1chrX

10588330

-PRDX4chrX

23700513

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MID1-PRDX4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MID1-PRDX4


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MID1

O15344

.
FUNCTION: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MID1-PRDX4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MID1-PRDX4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MID1-PRDX4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MID1-PRDX4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMID1C2936904Opitz GBBB Syndrome, X-Linked8CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgenePRDX4C0020456Hyperglycemia1CTD_human
TgenePRDX4C0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgenePRDX4C0162820Dermatitis, Allergic Contact1CTD_human
TgenePRDX4C0235874Disease Exacerbation1CTD_human
TgenePRDX4C0271650Impaired glucose tolerance1CTD_human
TgenePRDX4C1855520Hyperglycemia, Postprandial1CTD_human