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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MIEF2-RAI1 (FusionGDB2 ID:53296)

Fusion Gene Summary for MIEF2-RAI1

check button Fusion gene summary
Fusion gene informationFusion gene name: MIEF2-RAI1
Fusion gene ID: 53296
HgeneTgene
Gene symbol

MIEF2

RAI1

Gene ID

125170

493901

Gene namemitochondrial elongation factor 2ribonuclease A family member 12 (inactive)
SynonymsMID49|SMCR7HEL-S-85p|RAI1
Cytomap

17p11.2

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial dynamics protein MID49Smith-Magenis syndrome chromosomal region candidate gene 7 proteinSmith-Magenis syndrome chromosome region, candidate 7mitochondrial dynamic protein MID49mitochondrial dynamic protein of 49 kDamitochondrial dynamicprobable inactive ribonuclease-like protein 12epididymis secretory sperm binding protein Li 85pribonuclease A I1ribonuclease, RNase A family, 12 (non-active)ribonuclease-like protein 12
Modification date2020032720200313
UniProtAcc

Q96C03

.
Ensembl transtripts involved in fusion geneENST00000323019, ENST00000578174, 
ENST00000395704, ENST00000395703, 
ENST00000577216, ENST00000578621, 
ENST00000395706, 		ENST00000353383, 
ENST00000489697, ENST00000261641, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 8 X 3=168
# samples 18
** MAII scorelog2(1/4*10)=1.32192809488736log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIEF2 [Title/Abstract] AND RAI1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMIEF2(18168078)-RAI1(17707070), # samples:2
Anticipated loss of major functional domain due to fusion event.MIEF2-RAI1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMIEF2

GO:0003374

dynamin family protein polymerization involved in mitochondrial fission

23530241

HgeneMIEF2

GO:0007005

mitochondrion organization

21508961

HgeneMIEF2

GO:0090141

positive regulation of mitochondrial fission

23283981|23530241

HgeneMIEF2

GO:0090314

positive regulation of protein targeting to membrane

23283981

HgeneMIEF2

GO:0090314

positive regulation of protein targeting to membrane

23921378


check buttonFusion gene breakpoints across MIEF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RAI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A2LR-01AMIEF2chr17

18168078

+RAI1chr17

17707070

+
ChimerDB4BRCATCGA-AR-A2LR-01AMIEF2chr17

18168078

+RAI1chr17

17707070

+
ChimerDB4BRCATCGA-AR-A2LR-01AMIEF2chr17

18166562

+RAI1chr17

17707070

+


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Fusion Gene ORF analysis for MIEF2-RAI1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000323019ENST00000353383MIEF2chr17

18168078

+RAI1chr17

17707070

+
5CDS-intronENST00000323019ENST00000489697MIEF2chr17

18168078

+RAI1chr17

17707070

+
5CDS-intronENST00000323019ENST00000261641MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-3CDSENST00000578174ENST00000353383MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-intronENST00000578174ENST00000489697MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-intronENST00000578174ENST00000261641MIEF2chr17

18168078

+RAI1chr17

17707070

+
3UTR-3CDSENST00000395704ENST00000353383MIEF2chr17

18168078

+RAI1chr17

17707070

+
3UTR-intronENST00000395704ENST00000489697MIEF2chr17

18168078

+RAI1chr17

17707070

+
3UTR-intronENST00000395704ENST00000261641MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-3CDSENST00000395703ENST00000353383MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-intronENST00000395703ENST00000489697MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-intronENST00000395703ENST00000261641MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-3CDSENST00000577216ENST00000353383MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-intronENST00000577216ENST00000489697MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-intronENST00000577216ENST00000261641MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-3CDSENST00000578621ENST00000353383MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-intronENST00000578621ENST00000489697MIEF2chr17

18168078

+RAI1chr17

17707070

+
intron-intronENST00000578621ENST00000261641MIEF2chr17

18168078

+RAI1chr17

17707070

+
In-frameENST00000395706ENST00000353383MIEF2chr17

18168078

+RAI1chr17

17707070

+
5CDS-intronENST00000395706ENST00000489697MIEF2chr17

18168078

+RAI1chr17

17707070

+
5CDS-intronENST00000395706ENST00000261641MIEF2chr17

18168078

+RAI1chr17

17707070

+
Frame-shiftENST00000323019ENST00000353383MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000323019ENST00000489697MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000323019ENST00000261641MIEF2chr17

18166562

+RAI1chr17

17707070

+
Frame-shiftENST00000578174ENST00000353383MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000578174ENST00000489697MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000578174ENST00000261641MIEF2chr17

18166562

+RAI1chr17

17707070

+
Frame-shiftENST00000395704ENST00000353383MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000395704ENST00000489697MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000395704ENST00000261641MIEF2chr17

18166562

+RAI1chr17

17707070

+
Frame-shiftENST00000395703ENST00000353383MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000395703ENST00000489697MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000395703ENST00000261641MIEF2chr17

18166562

+RAI1chr17

17707070

+
3UTR-3CDSENST00000577216ENST00000353383MIEF2chr17

18166562

+RAI1chr17

17707070

+
3UTR-intronENST00000577216ENST00000489697MIEF2chr17

18166562

+RAI1chr17

17707070

+
3UTR-intronENST00000577216ENST00000261641MIEF2chr17

18166562

+RAI1chr17

17707070

+
Frame-shiftENST00000578621ENST00000353383MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000578621ENST00000489697MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000578621ENST00000261641MIEF2chr17

18166562

+RAI1chr17

17707070

+
Frame-shiftENST00000395706ENST00000353383MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000395706ENST00000489697MIEF2chr17

18166562

+RAI1chr17

17707070

+
5CDS-intronENST00000395706ENST00000261641MIEF2chr17

18166562

+RAI1chr17

17707070

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000323019MIEF2chr1718168078+ENST00000353383RAI1chr1717707070+393723096391213
ENST00000395706MIEF2chr1718168078+ENST00000353383RAI1chr1717707070+301413865391138199

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000323019ENST00000353383MIEF2chr1718168078+RAI1chr1717707070+0.417145880.58285415
ENST00000395706ENST00000353383MIEF2chr1718168078+RAI1chr1717707070+0.193106740.8068932

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Fusion Genomic Features for MIEF2-RAI1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MIEF2-RAI1


check button Go to

FGviewer for the breakpoints of chr17:18168078-chr17:17707070

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIEF2

Q96C03

.
FUNCTION: Mitochondrial outer membrane protein which regulates mitochondrial organization (PubMed:29361167). It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:29361167, ECO:0000269|PubMed:29899447}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAI1chr17:18168078chr17:17707070ENST00000353383261855_19031855.01907.0Zinc fingerPHD-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMIEF2chr17:18168078chr17:17707070ENST00000323019+141_220455.0Topological domainMitochondrial intermembrane
HgeneMIEF2chr17:18168078chr17:17707070ENST00000323019+1444_4540455.0Topological domainCytoplasmic
HgeneMIEF2chr17:18168078chr17:17707070ENST00000395704+141_220206.0Topological domainMitochondrial intermembrane
HgeneMIEF2chr17:18168078chr17:17707070ENST00000395704+1444_4540206.0Topological domainCytoplasmic
HgeneMIEF2chr17:18168078chr17:17707070ENST00000395706+141_220466.0Topological domainMitochondrial intermembrane
HgeneMIEF2chr17:18168078chr17:17707070ENST00000395706+1444_4540466.0Topological domainCytoplasmic
HgeneMIEF2chr17:18168078chr17:17707070ENST00000323019+1423_430455.0TransmembraneHelical
HgeneMIEF2chr17:18168078chr17:17707070ENST00000395704+1423_430206.0TransmembraneHelical
HgeneMIEF2chr17:18168078chr17:17707070ENST00000395706+1423_430466.0TransmembraneHelical
TgeneRAI1chr17:18168078chr17:17707070ENST00000353383261243_12491855.01907.0Compositional biasNote=Poly-Ser
TgeneRAI1chr17:18168078chr17:17707070ENST0000035338326124_1351855.01907.0Compositional biasNote=Poly-Pro
TgeneRAI1chr17:18168078chr17:17707070ENST00000353383261493_14961855.01907.0Compositional biasNote=Poly-Gly
TgeneRAI1chr17:18168078chr17:17707070ENST0000035338326156_3361855.01907.0Compositional biasNote=Gln-rich
TgeneRAI1chr17:18168078chr17:17707070ENST00000353383261628_16411855.01907.0Compositional biasNote=Ser-rich
TgeneRAI1chr17:18168078chr17:17707070ENST00000353383261746_17511855.01907.0Compositional biasNote=Poly-Ala
TgeneRAI1chr17:18168078chr17:17707070ENST0000035338326278_2911855.01907.0Compositional biasNote=Poly-Gln
TgeneRAI1chr17:18168078chr17:17707070ENST00000353383261160_11771855.01907.0MotifNuclear localization signal
TgeneRAI1chr17:18168078chr17:17707070ENST00000353383261223_12401855.01907.0MotifNuclear localization signal
TgeneRAI1chr17:18168078chr17:17707070ENST00000353383261780_18351855.01907.0Zinc fingerC2HC pre-PHD-type


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Fusion Gene Sequence for MIEF2-RAI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000323019_ENST00000353383_TCGA-AR-A2LR-01A_MIEF2_chr17_18168078_+_RAI1_chr17_17707070_length(transcript)=3937nt_BP=2309nt
GTATTTTGGCACCTGTGCGCTGGACTCGAGCGCTCCGATTGGAGTTAGGGCCTGCTTGTCTGCGTGCTGCGAAGTCCGCGGCTGCCCCCG
GGGCCCTAGTCGTTGGGTTCCAGGGTCCTTCACGTTCCATTCCCAGGCTGGTCTGAGCTCCGGGGCCGTGGTCCCGCTGCCTCCTCCGGT
CGTCGTGCGGAAGCTGCGACGCAGGCAGACCATGGCAGAGTTCTCCCAGAAACGGGGGAAGCGGCGTAGCGACGAAGGGCTGGGCAGCAT
GGTGGACTTCCTCCTGGCCAATGCCCGCCTGGTGCTGGGCGTGGGCGGGGCTGCTGTGCTGGGCATTGCCACCCTGGCCGTGAAGCGGTT
CATTGACAGGGCCACTAGCCCGCGGGATGAGGATGACACCAAGGCAGACAGCTGGAAGGAACTGAGCCTGCTCAAGGCCACACCACACCT
GCAGCCCCGGCCTCCACCTGCTGCCCTTAGCCAGCCAGTGTTGCCCTTGGCCCCCTCGTCGTCTGCCCCAGGTGGGTGGAAACGGGTGGT
TGCCATGTTTTCTAATGCTGGGGAGCTGCACCCACCTCCCTTCCAGGGATTTGAATAGTGGTTTTTCTCTAGCTTTTTGCCAGAACAAAG
GAGGGTACATTACTTAAACCCAGGGCATCAGGATGTGCTTGGGCTATGGTGGCCATAAACCCTGAGCCCAGAGAGCTTGGGTCACTGTCA
CCTGAGTGCAGCTGGGCTGCCTCAGGCAGCTTGGAGTGCCAGCCATTCCTGCAAGCACCGTTTCAGCTCTTGGGGCCAACCCCAGGACCT
TTGGCTCTGTCCATCACCAGCAACCAATCCACCAACAGAATGTGGTTTCTGCCATCCTGGGCAGAAGCTGAAGGCCAGCTTCACATTTCT
GCTGAGAGAAGGTGACTTAACGCCTTTTCCGGCCCTAGCTCCAGGCGTTTTGAGGCGTCTGGTGCCTGATGGTAGGTATGGTGTGTTTGT
TCTGTCCCCCAGGGGCTGGAGTCACCTGGTGCCCCTGAAGGACAGATTTTTGGCTGTTAAAGGATGGCATTTTCCTGCTGTCTTCTGTGC
GTTTAGTTTTCTTGCTGAGCGGGAGCTCAGTATGACTTGCCACCCACCTGATACCTCAGGGCAAGGCCCTTTTTCCCTCCAGCCAGGTGA
GTGTTTTCTTCAGGCAGCTGAGGGTCCTGGGGGAGCTGAGGCTCTGTGCTGCACCCCCAGCCCACAGCTGGGGCATCTCACTGGAGCTGT
TCCAGGCCCCACTGGAGAGCAGAGGACCTGATCCCCCACTAGAGAGGTCCGGTGTGCACAGCCGGCCTCCCAGTGTGCCAAAATGAACTG
CTCTCAGCTGATGGCTGTATTCTGACTTTGAAGCCTGTTAAGAGGTAGCAAGGGGGCTAGAGGAGGGAGATTCCACCTCCCCTCCCAAGT
GACCCTCCTCCTGCCTCTGGTATCCTTCCTTTTGAAACGAAGCTCAGCTTCGAAGATGTGAACAAGAATAAAAGGAAAAAATTCTAATGT
ATATATAACTCAGGCTGGATAAGGGAGTCTTGGTGCTTTCATACGCAGCTGTTGAGGGTTTTCTGTAAGTCCTGTGGCTTGTCCTGGCAC
TTTGGCAAGAGTGCTTGAGGTCAATTGGAGGTGGTAGAGTTTACTTTAAAAAGTAGCATCTTGGCCGGGTGTGGTGGCTCGCATCTGTAA
TCCCAGCACATCGGGAGGCCGAGGCGGGCGGATCACGAGGTCAAGAGATCGAGACCATCCTGACCAACATGATGAAACCCCAACTCTACT
AAAAAGACAAAAATTAGCTGGGCGTGGTGGCACGCACCTATAGTCCCAGCTACTCGGGAGGCCGAGGCAGGAGAATTGCTTGAACCCGGG
AGGTAGAGGTTGCAATGAGCTGAAATTGCACCACTGCACTCCAGACTGGCGACAGAGCAAGACTCTGTCTCAAAAAAATAAATAAATAAG
CATCTTGGCCCCGCGCTGTGGCTCACGCCTATAATCCCAGCACTTTGGGAAGCCGAGGCCGGTAGATCACCTGAGGTTGGGAATTCAAGA
CCAGGCTGACCAACGTGGAGAAACTCCATCTCTGGTAAAAATTCAAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAATCCCAGCTA
CTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGTGGTGAGCTGAGATCGTGCCAGTGCACTCCAGCCTAGGCA
ACAAGAGTGAAACTCTGTCTCAAAATAAAATAAAATAAAATAATAATAGTAATAATAAAATGTGTTCCAGCTGCCAAGAAGCCGGGGCCA
CCATTGGGTGCTGCCACAAAGGATGCCTCCACACCTACCACTACCCGTGTGCCAGCGATGCAGGTTGCATATTCATCGAAGAGAACTTTT
CTTTGAAATGTCCCAAACATAAGAGGCTGCCGTAGTAATCCACCCCAACGGCCGGAGGAGCCGCCGGAGCCCGCCTGCCCGCCCGCCGCC
GAAGGAGAGGAGCCGCCTGCGCAGCCCCCGGGCCTTTGAGCTGCTCCCAGCGCTGGTCCAGAGCCGATCCTTGATCCGGGTCCCGGATCG
TGGATCCGGCCGCCTAGGGCTCAGACTTGCGGCCCCGGGTTGGGAGGAAAACCCGTTCCGGAGCCGCCTGCTCCCGGAACCGGACGGCAC
AGGGCGTTCTTGCCCACCCCAGGGGCCAGGCTTGCGGAGGGGGAGCCCGCGGAGCGGCCAGACTCCCCGGGGCGCTCAGCCTCCGGCGAG
GGTGGGAGACGGCTTTGTCCTGGGGACACTTTCCCTCTGGAATCTCAAGACGACGTGGCACACATTCCACGTGGGTGCTGCCGCCACCCC
AGTCGGTCGTGGCGTGCAGCTGGGAGCCCTGGGCTTGGGGGTGGGGGTCGAAACAGTACTGGAAGAGGCGGAGGGCGGCTCCTAGCTCCG
TGGACTAGGCGGGGGAGAAAGGAAGCCTTTCTGAGAGCGGGCTAGGCCGGCACTGGAGAGGCCGGAGCCTTTGGAACAAACCGTGCGGAA
CGCGTCCAGGGGCCTTCCCGCCCAGCCTTTGCCAGATCTCTCGTGCGGTTCGGGCAAAGCCGGGGTAGACCTGGGCTATGCTCAGTTAGG
GGTTGCGGGATCCCCGAGTGTGGGCGGGACTGGGACACCCTTTGGCCTCTGTTTGTCCCCTTTCCAGTCCTCCACCCCACCCCTGGAGCC
CAGCCTGGGAGCGCAAAACCCAAGAAGCGGCCAGAACGCACCTCCGGCTCCGGCGGACGCGCGACCGTTGTGCACCACCAGGGACCGCCG
CGCCTACTCTGCACGGGAGCAGGGACAGCGCTAGATTTCGTGTACAAAACCTGTGTACCCCTCTATATATATGTTACATAGAATGTATAT
ATGTTGGGAACATGCTCGCTTCTCCCGTGTGTCGCCGCCGTGCGTCGTGCGCCCGCAACAGAGCCCCAACCGGGCCTTTGCCGGGTAAGG
GGCTACCGCGACGCCACTTGTCCACGCAGCCACCACCGGCCCGGGCCAGTCCCTGCCAGTCCGTCCGCCTGTCCGTCCGTGTCCTCAGCT
CTGTCCACGCTTCGATAGGCCTGACGCAGCCCCCAGCCCAGGGCCGCCCTAGCAACTTCCTGTACATATGACTGTAAAATGGTAAACGTG
TGTATTATATCTGGCCTCGTTATATAGTGTATATATATGTATACATATACATATATATAATATATATGAAGACTGTAAATGTTAAGACGA
CTAGTGTTCTTATTAGTATATTGCTTCACACTGAAGATTGTGTGTATCGAGCTGTTTCTAAAAGATGTTTATTTTCCTTAAGAGTAAAAA

>In-frame_ENST00000323019_ENST00000353383_TCGA-AR-A2LR-01A_MIEF2_chr17_18168078_+_RAI1_chr17_17707070_length(amino acids)=213AA_start in transcript=639_stop in transcript=1
MYPPLFWQKAREKPLFKSLEGRWVQLPSIRKHGNHPFPPTWGRRRGGQGQHWLAKGSRWRPGLQVWCGLEQAQFLPAVCLGVILIPRASG
PVNEPLHGQGGNAQHSSPAHAQHQAGIGQEEVHHAAQPFVATPLPPFLGELCHGLPASQLPHDDRRRQRDHGPGAQTSLGMEREGPWNPT

--------------------------------------------------------------
>In-frame_ENST00000395706_ENST00000353383_TCGA-AR-A2LR-01A_MIEF2_chr17_18168078_+_RAI1_chr17_17707070_length(transcript)=3014nt_BP=1386nt
CTGAGGCCTGCGCGACCCCGCCAGAGATGGGGCTGAGTCCCAATTTAGACAGGCAGACCATGGCAGAGTTCTCCCAGAAACGGGGGAAGC
GGCGTAGCGACGAAGGGCTGGGCAGCATGGTGGACTTCCTCCTGGCCAATGCCCGCCTGGTGCTGGGCGTGGGCGGGGCTGCTGTGCTGG
GCATTGCCACCCTGGCCGTGAAGCGGTTCATTGACAGGGCCACTAGCCCGCGGGATGAGGATGACACCAAGGCAGACAGCTGGAAGGAAC
TGAGCCTGCTCAAGGCCACACCACACCTGCAGCCCCGGCCTCCACCTGCTGCCCTTAGCCAGCCAGTGTTGCCCTTGGCCCCCTCGTCGT
CTGCCCCAGGTGGGTGGAAACGGGTGGTTGCCATGTTTTCTAATGCTGGGGAGCTGCACCCACCTCCCTTCCAGGGATTTGAATAGTGGT
TTTTCTCTAGCTTTTTGCCAGAACAAAGGAGGGTACATTACTTAAACCCAGGGCATCAGGATGTGCTTGGGCTATGGTGGCCATAAACCC
TGAGCCCAGAGAGCTTGGGTCACTGTCACCTGAGTGCAGCTGGGCTGCCTCAGGCAGCTTGGAGTGCCAGCCATTCCTGCAAGCACCGTT
TCAGCTCTTGGGGCCAACCCCAGGACCTTTGGCTCTGTCCATCACCAGCAACCAATCCACCAACAGAATGTGGTTTCTGCCATCCTGGGC
AGAAGCTGAAGGCCAGCTTCACATTTCTGCTGAGAGAAGGTGACTTAACGCCTTTTCCGGCCCTAGCTCCAGGCGTTTTGAGGCGTCTGG
TGCCTGATGGTAGGTATGGTGTGTTTGTTCTGTCCCCCAGGGGCTGGAGTCACCTGGTGCCCCTGAAGGACAGATTTTTGGCTGTTAAAG
GATGGCATTTTCCTGCTGTCTTCTGTGCGTTTAGTTTTCTTGCTGAGCGGGAGCTCAGTATGACTTGCCACCCACCTGATACCTCAGGGC
AAGGCCCTTTTTCCCTCCAGCCAGGTGAGTGTTTTCTTCAGGCAGCTGAGGGTCCTGGGGGAGCTGAGGCTCTGTGCTGCACCCCCAGCC
CACAGCTGGGGCATCTCACTGGAGCTGTTCCAGGCCCCACTGGAGAGCAGAGGACCTGATCCCCCACTAGAGAGGTCCGGTGTGCACAGC
CGGCCTCCCAGTGTGCCAAAATGAACTGCTCTCAGCTGATGGCTGTATTCTGACTTTGAAGCCTGTTAAGAGGTAGCAAGGGGGCTAGAG
GAGGGAGATTCCACCTCCCCTCCCAAGTGACCCTCCTCCTGCCTCTGGTATCCTTCCTTTTGAAACGAAGCTCAGCTTCGAAGATGTGAA
CAAGAATAAAAGGAAAAAATTCTAATGTATATATAAATGTGTTCCAGCTGCCAAGAAGCCGGGGCCACCATTGGGTGCTGCCACAAAGGA
TGCCTCCACACCTACCACTACCCGTGTGCCAGCGATGCAGGTTGCATATTCATCGAAGAGAACTTTTCTTTGAAATGTCCCAAACATAAG
AGGCTGCCGTAGTAATCCACCCCAACGGCCGGAGGAGCCGCCGGAGCCCGCCTGCCCGCCCGCCGCCGAAGGAGAGGAGCCGCCTGCGCA
GCCCCCGGGCCTTTGAGCTGCTCCCAGCGCTGGTCCAGAGCCGATCCTTGATCCGGGTCCCGGATCGTGGATCCGGCCGCCTAGGGCTCA
GACTTGCGGCCCCGGGTTGGGAGGAAAACCCGTTCCGGAGCCGCCTGCTCCCGGAACCGGACGGCACAGGGCGTTCTTGCCCACCCCAGG
GGCCAGGCTTGCGGAGGGGGAGCCCGCGGAGCGGCCAGACTCCCCGGGGCGCTCAGCCTCCGGCGAGGGTGGGAGACGGCTTTGTCCTGG
GGACACTTTCCCTCTGGAATCTCAAGACGACGTGGCACACATTCCACGTGGGTGCTGCCGCCACCCCAGTCGGTCGTGGCGTGCAGCTGG
GAGCCCTGGGCTTGGGGGTGGGGGTCGAAACAGTACTGGAAGAGGCGGAGGGCGGCTCCTAGCTCCGTGGACTAGGCGGGGGAGAAAGGA
AGCCTTTCTGAGAGCGGGCTAGGCCGGCACTGGAGAGGCCGGAGCCTTTGGAACAAACCGTGCGGAACGCGTCCAGGGGCCTTCCCGCCC
AGCCTTTGCCAGATCTCTCGTGCGGTTCGGGCAAAGCCGGGGTAGACCTGGGCTATGCTCAGTTAGGGGTTGCGGGATCCCCGAGTGTGG
GCGGGACTGGGACACCCTTTGGCCTCTGTTTGTCCCCTTTCCAGTCCTCCACCCCACCCCTGGAGCCCAGCCTGGGAGCGCAAAACCCAA
GAAGCGGCCAGAACGCACCTCCGGCTCCGGCGGACGCGCGACCGTTGTGCACCACCAGGGACCGCCGCGCCTACTCTGCACGGGAGCAGG
GACAGCGCTAGATTTCGTGTACAAAACCTGTGTACCCCTCTATATATATGTTACATAGAATGTATATATGTTGGGAACATGCTCGCTTCT
CCCGTGTGTCGCCGCCGTGCGTCGTGCGCCCGCAACAGAGCCCCAACCGGGCCTTTGCCGGGTAAGGGGCTACCGCGACGCCACTTGTCC
ACGCAGCCACCACCGGCCCGGGCCAGTCCCTGCCAGTCCGTCCGCCTGTCCGTCCGTGTCCTCAGCTCTGTCCACGCTTCGATAGGCCTG
ACGCAGCCCCCAGCCCAGGGCCGCCCTAGCAACTTCCTGTACATATGACTGTAAAATGGTAAACGTGTGTATTATATCTGGCCTCGTTAT
ATAGTGTATATATATGTATACATATACATATATATAATATATATGAAGACTGTAAATGTTAAGACGACTAGTGTTCTTATTAGTATATTG
CTTCACACTGAAGATTGTGTGTATCGAGCTGTTTCTAAAAGATGTTTATTTTCCTTAAGAGTAAAAAACAGTCATTGCATTCAGAAAAAA

>In-frame_ENST00000395706_ENST00000353383_TCGA-AR-A2LR-01A_MIEF2_chr17_18168078_+_RAI1_chr17_17707070_length(amino acids)=199AA_start in transcript=539_stop in transcript=1138
MSPESLGHCHLSAAGLPQAAWSASHSCKHRFSSWGQPQDLWLCPSPATNPPTECGFCHPGQKLKASFTFLLREGDLTPFPALAPGVLRRL
VPDGRYGVFVLSPRGWSHLVPLKDRFLAVKGWHFPAVFCAFSFLAERELSMTCHPPDTSGQGPFSLQPGECFLQAAEGPGGAEALCCTPS

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Fusion Gene PPI Analysis for MIEF2-RAI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MIEF2-RAI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MIEF2-RAI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRAI1C0795864Smith-Magenis syndrome17CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRAI1C366148517p11.2 Monosomy12CTD_human
TgeneRAI1C0028754Obesity2CTD_human
TgeneRAI1C2931246Potocki-Lupski syndrome2CTD_human;ORPHANET
TgeneRAI1C0003469Anxiety Disorders1CTD_human
TgeneRAI1C0018273Growth Disorders1CTD_human
TgeneRAI1C0020796Profound Mental Retardation1CTD_human
TgeneRAI1C0025202melanoma1CTD_human
TgeneRAI1C0025363Mental Retardation, Psychosocial1CTD_human
TgeneRAI1C0036341Schizophrenia1PSYGENET
TgeneRAI1C0376280Anxiety States, Neurotic1CTD_human
TgeneRAI1C0376634Craniofacial Abnormalities1CTD_human
TgeneRAI1C0392156Akathisia1CTD_human
TgeneRAI1C0525041Neurobehavioral Manifestations1CTD_human
TgeneRAI1C0700201Dyssomnias1CTD_human
TgeneRAI1C0752288Adjustment Sleep Disorder1CTD_human
TgeneRAI1C0752289Environmental Sleep Disorder1CTD_human
TgeneRAI1C0752291Limit-Setting Sleep Disorder1CTD_human
TgeneRAI1C0752292Nocturnal Eating-Drinking Syndrome1CTD_human
TgeneRAI1C0752293Sleep Disorders, Extrinsic1CTD_human
TgeneRAI1C0917816Mental deficiency1CTD_human
TgeneRAI1C1279420Anxiety neurosis (finding)1CTD_human
TgeneRAI1C1510586Autism Spectrum Disorders1CTD_human
TgeneRAI1C3714756Intellectual Disability1CTD_human
TgeneRAI1C3887612Psychomotor Agitation1CTD_human
TgeneRAI1C4225255YUAN-HAREL-LUPSKI SYNDROME1ORPHANET