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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MIPEP-TNFRSF19 (FusionGDB2 ID:53427)

Fusion Gene Summary for MIPEP-TNFRSF19

check button Fusion gene summary
Fusion gene informationFusion gene name: MIPEP-TNFRSF19
Fusion gene ID: 53427
HgeneTgene
Gene symbol

MIPEP

TNFRSF19

Gene ID

4285

55504

Gene namemitochondrial intermediate peptidaseTNF receptor superfamily member 19
SynonymsCOXPD31|HMIP|MIPTAJ|TAJ-alpha|TRADE|TROY
Cytomap

13q12.12

13q12.12

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial intermediate peptidasetumor necrosis factor receptor superfamily member 19toxicity and JNK inducer
Modification date2020031320200313
UniProtAcc

Q99797

.
Ensembl transtripts involved in fusion geneENST00000382172, ENST00000469167, 
ENST00000248484, ENST00000382263, 
ENST00000403372, ENST00000464735, 
ENST00000382258, 
Fusion gene scores* DoF score7 X 7 X 6=2947 X 6 X 6=252
# samples 78
** MAII scorelog2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIPEP [Title/Abstract] AND TNFRSF19 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMIPEP(24410379)-TNFRSF19(24190006), # samples:1
TNFRSF19(24200931)-MIPEP(24330757), # samples:1
Anticipated loss of major functional domain due to fusion event.TNFRSF19-MIPEP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TNFRSF19-MIPEP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TNFRSF19-MIPEP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MIPEP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TNFRSF19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5497-01AMIPEPchr13

24410379

-TNFRSF19chr13

24190006

+


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Fusion Gene ORF analysis for MIPEP-TNFRSF19

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000382172ENST00000248484MIPEPchr13

24410379

-TNFRSF19chr13

24190006

+
In-frameENST00000382172ENST00000382263MIPEPchr13

24410379

-TNFRSF19chr13

24190006

+
5CDS-5UTRENST00000382172ENST00000403372MIPEPchr13

24410379

-TNFRSF19chr13

24190006

+
5CDS-intronENST00000382172ENST00000464735MIPEPchr13

24410379

-TNFRSF19chr13

24190006

+
5CDS-intronENST00000382172ENST00000382258MIPEPchr13

24410379

-TNFRSF19chr13

24190006

+
intron-3CDSENST00000469167ENST00000248484MIPEPchr13

24410379

-TNFRSF19chr13

24190006

+
intron-3CDSENST00000469167ENST00000382263MIPEPchr13

24410379

-TNFRSF19chr13

24190006

+
intron-5UTRENST00000469167ENST00000403372MIPEPchr13

24410379

-TNFRSF19chr13

24190006

+
intron-intronENST00000469167ENST00000464735MIPEPchr13

24410379

-TNFRSF19chr13

24190006

+
intron-intronENST00000469167ENST00000382258MIPEPchr13

24410379

-TNFRSF19chr13

24190006

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000382172MIPEPchr1324410379-ENST00000248484TNFRSF19chr1324190006+4335175292825938
ENST00000382172MIPEPchr1324410379-ENST00000382263TNFRSF19chr1324190006+5539175292825938

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382172ENST00000248484MIPEPchr1324410379-TNFRSF19chr1324190006+0.0021359920.99786407
ENST00000382172ENST00000382263MIPEPchr1324410379-TNFRSF19chr1324190006+0.0011184030.99888164

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Fusion Genomic Features for MIPEP-TNFRSF19


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MIPEP-TNFRSF19


check button Go to

FGviewer for the breakpoints of chr13:24410379-chr13:24190006

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIPEP

Q99797

.
FUNCTION: Cleaves proteins, imported into the mitochondrion, to their mature size.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTNFRSF19chr13:24410379chr13:24190006ENST00000248484210116_14960.0418.0RepeatNote=TNFR-Cys 3
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000024848421074_11460.0418.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000038225829116_14960.0424.0RepeatNote=TNFR-Cys 3
TgeneTNFRSF19chr13:24410379chr13:24190006ENST000003822582974_11460.0424.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF19chr13:24410379chr13:24190006ENST00000382263210116_14960.0418.0RepeatNote=TNFR-Cys 3
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000038226321074_11460.0418.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000040337208116_1490286.0RepeatNote=TNFR-Cys 3
TgeneTNFRSF19chr13:24410379chr13:24190006ENST000004033720833_720286.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF19chr13:24410379chr13:24190006ENST000004033720874_1140286.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF19chr13:24410379chr13:24190006ENST00000248484210192_42360.0418.0Topological domainCytoplasmic
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000038225829192_42360.0424.0Topological domainCytoplasmic
TgeneTNFRSF19chr13:24410379chr13:24190006ENST00000382263210192_42360.0418.0Topological domainCytoplasmic
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000040337208192_4230286.0Topological domainCytoplasmic
TgeneTNFRSF19chr13:24410379chr13:24190006ENST000004033720830_1700286.0Topological domainExtracellular
TgeneTNFRSF19chr13:24410379chr13:24190006ENST00000248484210171_19160.0418.0TransmembraneHelical
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000038225829171_19160.0424.0TransmembraneHelical
TgeneTNFRSF19chr13:24410379chr13:24190006ENST00000382263210171_19160.0418.0TransmembraneHelical
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000040337208171_1910286.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000024848421033_7260.0418.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF19chr13:24410379chr13:24190006ENST000003822582933_7260.0424.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000038226321033_7260.0418.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000024848421030_17060.0418.0Topological domainExtracellular
TgeneTNFRSF19chr13:24410379chr13:24190006ENST000003822582930_17060.0424.0Topological domainExtracellular
TgeneTNFRSF19chr13:24410379chr13:24190006ENST0000038226321030_17060.0418.0Topological domainExtracellular


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Fusion Gene Sequence for MIPEP-TNFRSF19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000382172_ENST00000248484_TCGA-EJ-5497-01A_MIPEP_chr13_24410379_-_TNFRSF19_chr13_24190006_length(transcript)=4335nt_BP=1752nt
CGGCGTGGGCTGCTGCCTTGGAAACGCGGAGCGCGCGCTCCCAGCGAAAGCAGCAGGGCAGGGATCTGCGTTGGAGGAAGGGACTGCTCT
GGTGCTAGAATGCTGTGCGTCGGAAGGCTGGGCGGCTTGGGAGCCAGAGCAGCAGCTCTGCCGCCCCGCCGGGCGGGCCGGGGAAGCCTC
GAAGCCGGGATCCGGGCCCGAAGGGTCAGCACCAGCTGGTCTCCCGTGGGCGCCGCCTTCAATGTCAAGCCCCAGGGCAGCCGCTTGGAC
CTGTTCGGCGAGCGCCGGGGTCTTTTTGGAGTTCCTGAGCTGAGTGCCCCAGAAGGATTTCATATTGCACAAGAAAAAGCCTTGAGAAAG
ACAGAATTGCTTGTGGACCGTGCATGTTCCACCCCACCTGGGCCCCAGACCGTGCTGATCTTCGATGAGCTCTCGGATTCCTTATGCAGA
GTGGCCGACTTGGCTGATTTTGTGAAAATCGCTCACCCTGAGCCAGCATTCAGAGAAGCTGCGGAAGAAGCTTGTAGAAGTATTGGCACC
ATGGTAGAGAAGTTGAACACAAATGTGGATTTATATCAAAGTTTGCAAAAATTACTAGCTGATAAAAAACTTGTGGATTCCCTTGATCCA
GAAACAAGGCGAGTGGCTGAACTGTTTATGTTTGATTTTGAAATTAGTGGAATCCATCTAGACAAAGAAAAGCGTAAAAGAGCAGTGGAC
CTCAATGTTAAAATCTTGGATTTGAGTAGTACATTTCTTATGGGAACCAATTTTCCCAACAAGATTGAGAAGCATCTCTTACCAGAACAC
ATTCGTCGTAACTTTACATCTGCTGGGGATCATATCATAATTGATGGTCTCCACGCAGAATCACCAGATGACTTGGTGCGAGAAGCTGCT
TATAAAATTTTTCTTTATCCCAATGCTGGTCAATTGAAATGTTTAGAAGAATTGCTCAGCAGCAGAGATCTTCTGGCAAAGTTGGTGGGG
TATTCCACGTTTTCTCACAGGGCTCTCCAAGGAACGATAGCTAAAAATCCAGAGACTGTCATGCAGTTCCTTGAAAAACTATCTGACAAA
CTTTCTGAAAGAACTCTGAAAGATTTTGAGATGATACGAGGGATGAAAATGAAACTGAATCCTCAAAATTCCGAAGTAATGCCCTGGGAC
CCCCCTTACTACAGTGGTGTGATTCGTGCAGAAAGGTATAATATTGAGCCCAGCCTATATTGCCCGTTTTTCTCTCTTGGAGCATGCATG
GAAGGCCTGAATATTTTGCTTAACAGACTGTTGGGGATTTCATTATATGCAGAGCAGCCTGCAAAAGGAGAGGTGTGGAGCGAAGATGTC
CGAAAACTGGCTGTTGTTCATGAATCTGAAGGATTGTTGGGGTACATTTACTGTGATTTTTTTCAGCGAGCAGACAAACCACATCAGGAT
TGCCATTTCACTATCCGTGGAGGCAGACTAAAGGAAGATGGAGACTATCAACTCCCAGTTGTAGTTCTTATGCTGAATCTTCCCCGTTCC
TCAAGGAGTTCTCCAACTTTGCTAACTCCTAGCATGATGGAAAATCTTTTCCATGAAATGGGACATGCCATGCATTCAATGCTAGGACGT
ACTCGTTACCAACACGTCACTGGGACCAGGTGCCCTACTGATTTTGCTGAGGTTCCTTCTATTCTGATGGAGTACTTTGCAAATGATTAT
CGAGTAGTTAACCAATTTGCCAGACATTATCAGACTGGACAGGAATGTGGCTTCGGCTATGGGGAGGATGCACAGTGTGTGACGTGCCGG
CTGCACAGGTTCAAGGAGGACTGGGGCTTCCAGAAATGCAAGCCCTGTCTGGACTGCGCAGTGGTGAACCGCTTTCAGAAGGCAAATTGT
TCAGCCACCAGTGATGCCATCTGCGGGGACTGCTTGCCAGGATTTTATAGGAAGACGAAACTTGTCGGCTTTCAAGACATGGAGTGTGTG
CCTTGTGGAGACCCTCCTCCTCCTTACGAACCGCACTGTGCCAGCAAGGTCAACCTCGTGAAGATCGCGTCCACGGCCTCCAGCCCACGG
GACACGGCGCTGGCTGCCGTTATCTGCAGCGCTCTGGCCACCGTCCTGCTGGCCCTGCTCATCCTCTGTGTCATCTATTGTAAGAGACAG
TTTATGGAGAAGAAACCCAGCTGGTCTCTGCGGTCACAGGACATTCAGTACAACGGCTCTGAGCTGTCGTGTTTTGACAGACCTCAGCTC
CACGAATATGCCCACAGAGCCTGCTGCCAGTGCCGCCGTGACTCAGTGCAGACCTGCGGGCCGGTGCGCTTGCTCCCATCCATGTGCTGT
GAGGAGGCCTGCAGCCCCAACCCGGCGACTCTTGGTTGTGGGGTGCATTCTGCAGCCAGTCTTCAGGCAAGAAACGCAGGCCCAGCCGGG
GAGATGGTGCCGACTTTCTTCGGATCCCTCACGCAGTCCATCTGTGGCGAGTTTTCAGATGCCTGGCCTCTGATGCAGAATCCCATGGGT
GGTGACAACATCTCTTTTTGTGACTCTTATCCTGAACTCACTGGAGAAGACATTCATTCTCTCAATCCAGAACTTGAAAGCTCAACGTCT
TTGGATTCAAATAGCAGTCAAGATTTGGTTGGTGGGGCTGTTCCAGTCCAGTCTCATTCTGAAAACTTTACAGCAGCTACTGATTTATCT
AGATATAACAACACACTGGTAGAATCAGCATCAACTCAGGATGCACTAACTATGAGAAGCCAGCTAGATCAGGAGAGTGGTGCTGTCATC
CACCCAGCCACTCAGACGTCCCTCCAGGAAGCTTAAAGAACCTGCTTCTTTCTGCAGTAGAAGCGTGTGCTGGAACCCAAAGAGTACTCC
TTTGTTAGGCTTATGGACTGAGCAGTCTGGACCTTGCATGGCTTCTGGGGCAAAAATAAATCTGAACCAAACTGACGGCATTTGAAGCCT
TTCAGCCAGTTGCTTCTGAGCCAGACCAGCTGTAAGCTGAAACCTCAATGAATAACAAGAAAAGACTCCAGGCCGACTCATGATACTCTG
CATCTTTCCTACATGAGAAGCTTCTCTGCCACAAAAGTGACTTCAAAGACGGATGGGTTGAGCTGGCAGCCTATGAGATTGTGGACATAT
AACAAGAAACAGAAATGCCCTCATGCTTATTTTCATGGTGATTGTGGTTTTACAAGACTGAAGACCCAGAGTATACTTTTTCTTTCCAGA
AATAATTTCATACCGCCTATGAAATATCAGATAAATTACCTTAGCTTTTATGTAGAATGGGTTCAAAAGTGAGTGTTTCTATTTGAGAAG
GACACTTTTTCATCATCTAAACTGATTCGCATAGGTGGTTAGAATGGCCCTCATATTGCCTGCCTAAATCTTGGGTTTATTAGATGAAGT
TTACTGAATCAGAGGAATCAGACAGAGGAGGATAGCTCTTTCCAGAATCCACACTTCTGACCTCAGCCTCGGTCTCATGAACACCCGCTG
ATCTCAGGAGAACACCTGGGCTAGGGAATGTGGTCGAGAAAGGGCAGCCCATTGCCCAGAATTAACACATATTGTAGAGACTTGTATGCA
AAGGTTGGCATATTTATATGAAAATTAGTTGCTATAGAAACATTTGTTGCATCTGTCCCTCTGCCTGAGCTTAGAAGGTTATAGAAAAAG
GGTATTTATAAACATAAATGACCTTTTACTTGCATTGTATCTTATACTAAAGGCTTTAGAAATTACAACATATCAGGTTCCCCTACTACT
GAAGTAGCCTTCCGTGAGAACACACCACATGTTAGGACTAGAAGAAAATGCACAATTTGTAGGGGTTTGGATGAAGCAGCTGTAACTGCC
CTAGTGTAGTTTGACCAGGACATTGTCGTGCTCCTTCCAATTGTGTAAGATTAGTTAGCACATCATCTCCTACTTTAGCCATCCGGTGTT
GGATTTAAGAGGACGGTGCTTCTTTCTATTAAAGTGCTCCATCCCCTACCATCTACACATTAGCATTGTCTCTAGAGCTAAGACAGAAAT
TAACCCCGTTCAGTCACAAAGCAGGGAATGGTTCATTTACTCTTAATCTTTATGCCCTGGAGAAGACCTACTTGAACAGGGCATATTTTT
TAGACTTCTGAACATCAGTATGTTCGAGGGTACTATGATATTTTGGTTTGGAATTGCCCTGCCCAAGTCACTGTCTTTTAACTTTTAAAC
TGAATATTAAAATGTATCTGTCTTTCCTAGTATGTTTTTATCTTCTCATGTATTATCCATGGTTTTCTCTGTTTGTGACAGATTAGTAAA

>In-frame_ENST00000382172_ENST00000248484_TCGA-EJ-5497-01A_MIPEP_chr13_24410379_-_TNFRSF19_chr13_24190006_length(amino acids)=938AA_start in transcript=9_stop in transcript=2825
MLPWKRGARAPSESSRAGICVGGRDCSGARMLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG
ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE
KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR
NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSE
RTLKDFEMIRGMKMKLNPQNSEVMPWDPPYYSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL
AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSSPTLLTPSMMENLFHEMGHAMHSMLGRTRY
QHVTGTRCPTDFAEVPSILMEYFANDYRVVNQFARHYQTGQECGFGYGEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANCSAT
SDAICGDCLPGFYRKTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKIASTASSPRDTALAAVICSALATVLLALLILCVIYCKRQFME
KKPSWSLRSQDIQYNGSELSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASLQARNAGPAGEMV
PTFFGSLTQSICGEFSDAWPLMQNPMGGDNISFCDSYPELTGEDIHSLNPELESSTSLDSNSSQDLVGGAVPVQSHSENFTAATDLSRYN

--------------------------------------------------------------
>In-frame_ENST00000382172_ENST00000382263_TCGA-EJ-5497-01A_MIPEP_chr13_24410379_-_TNFRSF19_chr13_24190006_length(transcript)=5539nt_BP=1752nt
CGGCGTGGGCTGCTGCCTTGGAAACGCGGAGCGCGCGCTCCCAGCGAAAGCAGCAGGGCAGGGATCTGCGTTGGAGGAAGGGACTGCTCT
GGTGCTAGAATGCTGTGCGTCGGAAGGCTGGGCGGCTTGGGAGCCAGAGCAGCAGCTCTGCCGCCCCGCCGGGCGGGCCGGGGAAGCCTC
GAAGCCGGGATCCGGGCCCGAAGGGTCAGCACCAGCTGGTCTCCCGTGGGCGCCGCCTTCAATGTCAAGCCCCAGGGCAGCCGCTTGGAC
CTGTTCGGCGAGCGCCGGGGTCTTTTTGGAGTTCCTGAGCTGAGTGCCCCAGAAGGATTTCATATTGCACAAGAAAAAGCCTTGAGAAAG
ACAGAATTGCTTGTGGACCGTGCATGTTCCACCCCACCTGGGCCCCAGACCGTGCTGATCTTCGATGAGCTCTCGGATTCCTTATGCAGA
GTGGCCGACTTGGCTGATTTTGTGAAAATCGCTCACCCTGAGCCAGCATTCAGAGAAGCTGCGGAAGAAGCTTGTAGAAGTATTGGCACC
ATGGTAGAGAAGTTGAACACAAATGTGGATTTATATCAAAGTTTGCAAAAATTACTAGCTGATAAAAAACTTGTGGATTCCCTTGATCCA
GAAACAAGGCGAGTGGCTGAACTGTTTATGTTTGATTTTGAAATTAGTGGAATCCATCTAGACAAAGAAAAGCGTAAAAGAGCAGTGGAC
CTCAATGTTAAAATCTTGGATTTGAGTAGTACATTTCTTATGGGAACCAATTTTCCCAACAAGATTGAGAAGCATCTCTTACCAGAACAC
ATTCGTCGTAACTTTACATCTGCTGGGGATCATATCATAATTGATGGTCTCCACGCAGAATCACCAGATGACTTGGTGCGAGAAGCTGCT
TATAAAATTTTTCTTTATCCCAATGCTGGTCAATTGAAATGTTTAGAAGAATTGCTCAGCAGCAGAGATCTTCTGGCAAAGTTGGTGGGG
TATTCCACGTTTTCTCACAGGGCTCTCCAAGGAACGATAGCTAAAAATCCAGAGACTGTCATGCAGTTCCTTGAAAAACTATCTGACAAA
CTTTCTGAAAGAACTCTGAAAGATTTTGAGATGATACGAGGGATGAAAATGAAACTGAATCCTCAAAATTCCGAAGTAATGCCCTGGGAC
CCCCCTTACTACAGTGGTGTGATTCGTGCAGAAAGGTATAATATTGAGCCCAGCCTATATTGCCCGTTTTTCTCTCTTGGAGCATGCATG
GAAGGCCTGAATATTTTGCTTAACAGACTGTTGGGGATTTCATTATATGCAGAGCAGCCTGCAAAAGGAGAGGTGTGGAGCGAAGATGTC
CGAAAACTGGCTGTTGTTCATGAATCTGAAGGATTGTTGGGGTACATTTACTGTGATTTTTTTCAGCGAGCAGACAAACCACATCAGGAT
TGCCATTTCACTATCCGTGGAGGCAGACTAAAGGAAGATGGAGACTATCAACTCCCAGTTGTAGTTCTTATGCTGAATCTTCCCCGTTCC
TCAAGGAGTTCTCCAACTTTGCTAACTCCTAGCATGATGGAAAATCTTTTCCATGAAATGGGACATGCCATGCATTCAATGCTAGGACGT
ACTCGTTACCAACACGTCACTGGGACCAGGTGCCCTACTGATTTTGCTGAGGTTCCTTCTATTCTGATGGAGTACTTTGCAAATGATTAT
CGAGTAGTTAACCAATTTGCCAGACATTATCAGACTGGACAGGAATGTGGCTTCGGCTATGGGGAGGATGCACAGTGTGTGACGTGCCGG
CTGCACAGGTTCAAGGAGGACTGGGGCTTCCAGAAATGCAAGCCCTGTCTGGACTGCGCAGTGGTGAACCGCTTTCAGAAGGCAAATTGT
TCAGCCACCAGTGATGCCATCTGCGGGGACTGCTTGCCAGGATTTTATAGGAAGACGAAACTTGTCGGCTTTCAAGACATGGAGTGTGTG
CCTTGTGGAGACCCTCCTCCTCCTTACGAACCGCACTGTGCCAGCAAGGTCAACCTCGTGAAGATCGCGTCCACGGCCTCCAGCCCACGG
GACACGGCGCTGGCTGCCGTTATCTGCAGCGCTCTGGCCACCGTCCTGCTGGCCCTGCTCATCCTCTGTGTCATCTATTGTAAGAGACAG
TTTATGGAGAAGAAACCCAGCTGGTCTCTGCGGTCACAGGACATTCAGTACAACGGCTCTGAGCTGTCGTGTTTTGACAGACCTCAGCTC
CACGAATATGCCCACAGAGCCTGCTGCCAGTGCCGCCGTGACTCAGTGCAGACCTGCGGGCCGGTGCGCTTGCTCCCATCCATGTGCTGT
GAGGAGGCCTGCAGCCCCAACCCGGCGACTCTTGGTTGTGGGGTGCATTCTGCAGCCAGTCTTCAGGCAAGAAACGCAGGCCCAGCCGGG
GAGATGGTGCCGACTTTCTTCGGATCCCTCACGCAGTCCATCTGTGGCGAGTTTTCAGATGCCTGGCCTCTGATGCAGAATCCCATGGGT
GGTGACAACATCTCTTTTTGTGACTCTTATCCTGAACTCACTGGAGAAGACATTCATTCTCTCAATCCAGAACTTGAAAGCTCAACGTCT
TTGGATTCAAATAGCAGTCAAGATTTGGTTGGTGGGGCTGTTCCAGTCCAGTCTCATTCTGAAAACTTTACAGCAGCTACTGATTTATCT
AGATATAACAACACACTGGTAGAATCAGCATCAACTCAGGATGCACTAACTATGAGAAGCCAGCTAGATCAGGAGAGTGGTGCTGTCATC
CACCCAGCCACTCAGACGTCCCTCCAGGAAGCTTAAAGAACCTGCTTCTTTCTGCAGTAGAAGCGTGTGCTGGAACCCAAAGAGTACTCC
TTTGTTAGGCTTATGGACTGAGCAGTCTGGACCTTGCATGGCTTCTGGGGCAAAAATAAATCTGAACCAAACTGACGGCATTTGAAGCCT
TTCAGCCAGTTGCTTCTGAGCCAGACCAGCTGTAAGCTGAAACCTCAATGAATAACAAGAAAAGACTCCAGGCCGACTCATGATACTCTG
CATCTTTCCTACATGAGAAGCTTCTCTGCCACAAAAGTGACTTCAAAGACGGATGGGTTGAGCTGGCAGCCTATGAGATTGTGGACATAT
AACAAGAAACAGAAATGCCCTCATGCTTATTTTCATGGTGATTGTGGTTTTACAAGACTGAAGACCCAGAGTATACTTTTTCTTTCCAGA
AATAATTTCATACCGCCTATGAAATATCAGATAAATTACCTTAGCTTTTATGTAGAATGGGTTCAAAAGTGAGTGTTTCTATTTGAGAAG
GACACTTTTTCATCATCTAAACTGATTCGCATAGGTGGTTAGAATGGCCCTCATATTGCCTGCCTAAATCTTGGGTTTATTAGATGAAGT
TTACTGAATCAGAGGAATCAGACAGAGGAGGATAGCTCTTTCCAGAATCCACACTTCTGACCTCAGCCTCGGTCTCATGAACACCCGCTG
ATCTCAGGAGAACACCTGGGCTAGGGAATGTGGTCGAGAAAGGGCAGCCCATTGCCCAGAATTAACACATATTGTAGAGACTTGTATGCA
AAGGTTGGCATATTTATATGAAAATTAGTTGCTATAGAAACATTTGTTGCATCTGTCCCTCTGCCTGAGCTTAGAAGGTTATAGAAAAAG
GGTATTTATAAACATAAATGACCTTTTACTTGCATTGTATCTTATACTAAAGGCTTTAGAAATTACAACATATCAGGTTCCCCTACTACT
GAAGTAGCCTTCCGTGAGAACACACCACATGTTAGGACTAGAAGAAAATGCACAATTTGTAGGGGTTTGGATGAAGCAGCTGTAACTGCC
CTAGTGTAGTTTGACCAGGACATTGTCGTGCTCCTTCCAATTGTGTAAGATTAGTTAGCACATCATCTCCTACTTTAGCCATCCGGTGTT
GGATTTAAGAGGACGGTGCTTCTTTCTATTAAAGTGCTCCATCCCCTACCATCTACACATTAGCATTGTCTCTAGAGCTAAGACAGAAAT
TAACCCCGTTCAGTCACAAAGCAGGGAATGGTTCATTTACTCTTAATCTTTATGCCCTGGAGAAGACCTACTTGAACAGGGCATATTTTT
TAGACTTCTGAACATCAGTATGTTCGAGGGTACTATGATATTTTGGTTTGGAATTGCCCTGCCCAAGTCACTGTCTTTTAACTTTTAAAC
TGAATATTAAAATGTATCTGTCTTTCCTAGTATGTTTTTATCTTCTCATGTATTATCCATGGTTTTCTCTGTTTGTGACAGATTAGTAAA
ATTTAATGAGCCCTCTTTCTTGTGGCCGTTTCTCCATAGTTTTAGGTTTTGATATGTGTTTACTAGCTTGCCTGTGTCTGGTACATCTCA
TGACCTCAATTCCCTCACCTGAAATAGGAAATGAGAATGTTTCATTGTAGCCCCAAGCGGTCATGTCAACCTAGTGCCTAGTCATAATTA
ATTGACTTTTCCTGTATTACTTCTTTTTTTAAGTATAAACCAATGATCCTTTGGTAGTCAAGAACTCTTAGGAACATTGCCTTTTGGACA
TGTAAAATATTTAGGATTTGACCACACAATGGCTATGAAAATGCAAGTAGTTTCCTCGCGTGACCTCACCATGATTCACATACGTGCCAC
TGTTTGAAATCTGGTCTGTTTGCATTTCTGTTATGACAGAGAGATGATGTTTGCATTTCTGTTATGACAGAGAGATGATGAAAGTAGGCA
GGGCTGTGTTCCTTTGTGTAGCCTGTATATATTTTCCATATGTAGAGCCCTGATTAACTTCAAGGACAAACACTGGCTGGAGAAAGCCAG
ACTGATGGGAATGAGACTTTGGCCAAAAATCCCAAAACATCATTTTCAATCAGTAGAGAAGTGCTTAGGGTTGAAAATTGATTTCATTTG
CTACTGAATTTGGTAAATCCTGGGTAACTTTTATCAAGATGAAGACATTTTACCCTACCTACTCTAGAAATATACAACAATGTTATATTT
TACACTCCTTGGAAACATTTGAGGAAAAAAATGCAATTTGCACTTCACTTTGTTGGAATATCCCATAGCACTCAATAAACTCAGCTGCTA
GAGTGCCGATGTCAGGAGGGCTGTGTCGGGTAATGCGTGTGGCTGAATGGGCATAACCACTGTGGCTTCTTGTGCTGCAGAAGCTCGTTG
ACAAGACTGAGGAGGATTTCAAGAGCAACCAAGTAAAGTCATGAATTTTCTAATTTTGTGTATATGGAATATATTTTTAAATAGAGATTT
TTCTACTTTAGATAATGTGTTAATATTGCTATTACCTAGGTTAAGCACTATTGTCTGTGCTAGTAAGAAAAAGAAAGGAAAACCATCATT
GCTTTATAGTAGCTTATATCAATTTAGATTTCATCATTACTATTTTGCATACTGGAATTTATAAATGTGTAAATTATCATTTTCTTAGTT

>In-frame_ENST00000382172_ENST00000382263_TCGA-EJ-5497-01A_MIPEP_chr13_24410379_-_TNFRSF19_chr13_24190006_length(amino acids)=938AA_start in transcript=9_stop in transcript=2825
MLPWKRGARAPSESSRAGICVGGRDCSGARMLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG
ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE
KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR
NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSE
RTLKDFEMIRGMKMKLNPQNSEVMPWDPPYYSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL
AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSSPTLLTPSMMENLFHEMGHAMHSMLGRTRY
QHVTGTRCPTDFAEVPSILMEYFANDYRVVNQFARHYQTGQECGFGYGEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANCSAT
SDAICGDCLPGFYRKTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKIASTASSPRDTALAAVICSALATVLLALLILCVIYCKRQFME
KKPSWSLRSQDIQYNGSELSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASLQARNAGPAGEMV
PTFFGSLTQSICGEFSDAWPLMQNPMGGDNISFCDSYPELTGEDIHSLNPELESSTSLDSNSSQDLVGGAVPVQSHSENFTAATDLSRYN

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Fusion Gene PPI Analysis for MIPEP-TNFRSF19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MIPEP-TNFRSF19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MIPEP-TNFRSF19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMIPEPC4310661COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 312CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneTNFRSF19C0025202melanoma1CTD_human
TgeneTNFRSF19C0027439Nasopharyngeal Neoplasms1CTD_human
TgeneTNFRSF19C0238301Cancer of Nasopharynx1CTD_human