FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MKL2-PARN (FusionGDB2 ID:53747)

Fusion Gene Summary for MKL2-PARN

check button Fusion gene summary
Fusion gene informationFusion gene name: MKL2-PARN
Fusion gene ID: 53747
HgeneTgene
Gene symbol

MKL2

PARN

Gene ID

57496

5073

Gene namemyocardin related transcription factor Bpoly(A)-specific ribonuclease
SynonymsMKL2|MRTF-B|NPD001DAN|DKCB6|PFBMFT4
Cytomap

16p13.12

16p13.12

Type of geneprotein-codingprotein-coding
Descriptionmyocardin-related transcription factor BCTA-276F8.1MKL and myocardin family member 2MKL/myocardin like 2MKL/myocardin-like protein 2MKL1/myocardin like 2megakaryoblastic leukemia 2poly(A)-specific ribonuclease PARNdeadenylating nucleasedeadenylation nucleasepolyadenylate-specific ribonuclease
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000571589, ENST00000574045, 
ENST00000318282, ENST00000572567, 
ENST00000341243, ENST00000575537, 
ENST00000573051, 		ENST00000437198, 
ENST00000420015, ENST00000341484, 
ENST00000539279, ENST00000566021, 
Fusion gene scores* DoF score19 X 10 X 11=20909 X 8 X 4=288
# samples 209
** MAII scorelog2(20/2090*10)=-3.38543103719352
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MKL2 [Title/Abstract] AND PARN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMKL2(14234617)-PARN(14576684), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMKL2

GO:0045844

positive regulation of striated muscle tissue development

14565952

HgeneMKL2

GO:0045944

positive regulation of transcription by RNA polymerase II

14565952

TgenePARN

GO:0000495

box H/ACA snoRNA 3'-end processing

22442037

TgenePARN

GO:0010587

miRNA catabolic process

25049417

TgenePARN

GO:0071051

polyadenylation-dependent snoRNA 3'-end processing

22442037


check buttonFusion gene breakpoints across MKL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PARN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-HZ-8519MKL2chr16

14234617

+PARNchr16

14576684

-
ChimerDB4SKCMTCGA-FS-A1ZC-06AMKL2chr16

14234617

+PARNchr16

14576684

-


Top

Fusion Gene ORF analysis for MKL2-PARN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000571589ENST00000437198MKL2chr16

14234617

+PARNchr16

14576684

-
In-frameENST00000571589ENST00000420015MKL2chr16

14234617

+PARNchr16

14576684

-
In-frameENST00000571589ENST00000341484MKL2chr16

14234617

+PARNchr16

14576684

-
In-frameENST00000571589ENST00000539279MKL2chr16

14234617

+PARNchr16

14576684

-
5CDS-intronENST00000571589ENST00000566021MKL2chr16

14234617

+PARNchr16

14576684

-
In-frameENST00000574045ENST00000437198MKL2chr16

14234617

+PARNchr16

14576684

-
In-frameENST00000574045ENST00000420015MKL2chr16

14234617

+PARNchr16

14576684

-
In-frameENST00000574045ENST00000341484MKL2chr16

14234617

+PARNchr16

14576684

-
In-frameENST00000574045ENST00000539279MKL2chr16

14234617

+PARNchr16

14576684

-
5CDS-intronENST00000574045ENST00000566021MKL2chr16

14234617

+PARNchr16

14576684

-
In-frameENST00000318282ENST00000437198MKL2chr16

14234617

+PARNchr16

14576684

-
In-frameENST00000318282ENST00000420015MKL2chr16

14234617

+PARNchr16

14576684

-
In-frameENST00000318282ENST00000341484MKL2chr16

14234617

+PARNchr16

14576684

-
In-frameENST00000318282ENST00000539279MKL2chr16

14234617

+PARNchr16

14576684

-
5CDS-intronENST00000318282ENST00000566021MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000572567ENST00000437198MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000572567ENST00000420015MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000572567ENST00000341484MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000572567ENST00000539279MKL2chr16

14234617

+PARNchr16

14576684

-
intron-intronENST00000572567ENST00000566021MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000341243ENST00000437198MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000341243ENST00000420015MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000341243ENST00000341484MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000341243ENST00000539279MKL2chr16

14234617

+PARNchr16

14576684

-
intron-intronENST00000341243ENST00000566021MKL2chr16

14234617

+PARNchr16

14576684

-
3UTR-3CDSENST00000575537ENST00000437198MKL2chr16

14234617

+PARNchr16

14576684

-
3UTR-3CDSENST00000575537ENST00000420015MKL2chr16

14234617

+PARNchr16

14576684

-
3UTR-3CDSENST00000575537ENST00000341484MKL2chr16

14234617

+PARNchr16

14576684

-
3UTR-3CDSENST00000575537ENST00000539279MKL2chr16

14234617

+PARNchr16

14576684

-
3UTR-intronENST00000575537ENST00000566021MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000573051ENST00000437198MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000573051ENST00000420015MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000573051ENST00000341484MKL2chr16

14234617

+PARNchr16

14576684

-
intron-3CDSENST00000573051ENST00000539279MKL2chr16

14234617

+PARNchr16

14576684

-
intron-intronENST00000573051ENST00000566021MKL2chr16

14234617

+PARNchr16

14576684

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000571589MKL2chr1614234617+ENST00000437198PARNchr1614576684-1782326172765197
ENST00000571589MKL2chr1614234617+ENST00000420015PARNchr1614576684-1210326172765197
ENST00000571589MKL2chr1614234617+ENST00000341484PARNchr1614576684-878326172765197
ENST00000571589MKL2chr1614234617+ENST00000539279PARNchr1614576684-815326172765197
ENST00000574045MKL2chr1614234617+ENST00000437198PARNchr1614576684-1765309155748197
ENST00000574045MKL2chr1614234617+ENST00000420015PARNchr1614576684-1193309155748197
ENST00000574045MKL2chr1614234617+ENST00000341484PARNchr1614576684-861309155748197
ENST00000574045MKL2chr1614234617+ENST00000539279PARNchr1614576684-798309155748197
ENST00000318282MKL2chr1614234617+ENST00000437198PARNchr1614576684-1740284130723197
ENST00000318282MKL2chr1614234617+ENST00000420015PARNchr1614576684-1168284130723197
ENST00000318282MKL2chr1614234617+ENST00000341484PARNchr1614576684-836284130723197
ENST00000318282MKL2chr1614234617+ENST00000539279PARNchr1614576684-773284130723197

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000571589ENST00000437198MKL2chr1614234617+PARNchr1614576684-0.001074390.9989256
ENST00000571589ENST00000420015MKL2chr1614234617+PARNchr1614576684-0.0022731470.99772686
ENST00000571589ENST00000341484MKL2chr1614234617+PARNchr1614576684-0.0054108610.9945891
ENST00000571589ENST00000539279MKL2chr1614234617+PARNchr1614576684-0.0075217010.99247825
ENST00000574045ENST00000437198MKL2chr1614234617+PARNchr1614576684-0.0016492330.99835074
ENST00000574045ENST00000420015MKL2chr1614234617+PARNchr1614576684-0.0034744210.9965256
ENST00000574045ENST00000341484MKL2chr1614234617+PARNchr1614576684-0.0074506710.9925493
ENST00000574045ENST00000539279MKL2chr1614234617+PARNchr1614576684-0.0097254070.99027455
ENST00000318282ENST00000437198MKL2chr1614234617+PARNchr1614576684-0.001601820.9983981
ENST00000318282ENST00000420015MKL2chr1614234617+PARNchr1614576684-0.0042519460.9957481
ENST00000318282ENST00000341484MKL2chr1614234617+PARNchr1614576684-0.0095351190.9904649
ENST00000318282ENST00000539279MKL2chr1614234617+PARNchr1614576684-0.0128234170.9871766

Top

Fusion Genomic Features for MKL2-PARN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MKL2-PARN


check button Go to

FGviewer for the breakpoints of chr16:14234617-chr16:14576684

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMKL2chr16:14234617chr16:14576684ENST00000318282+216545_60151.3333333333333361050.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14234617chr16:14576684ENST00000341243+115545_6010.01089.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14234617chr16:14576684ENST00000573051+19545_6010379.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14234617chr16:14576684ENST00000574045+317545_60151.3333333333333361050.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14234617chr16:14576684ENST00000318282+216671_78751.3333333333333361050.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14234617chr16:14576684ENST00000341243+115671_7870.01089.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14234617chr16:14576684ENST00000573051+19671_7870379.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14234617chr16:14576684ENST00000574045+317671_78751.3333333333333361050.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14234617chr16:14576684ENST00000318282+216389_42351.3333333333333361050.0DomainSAP
HgeneMKL2chr16:14234617chr16:14576684ENST00000341243+115389_4230.01089.0DomainSAP
HgeneMKL2chr16:14234617chr16:14576684ENST00000573051+19389_4230379.0DomainSAP
HgeneMKL2chr16:14234617chr16:14576684ENST00000574045+317389_42351.3333333333333361050.0DomainSAP
HgeneMKL2chr16:14234617chr16:14576684ENST00000318282+216128_15351.3333333333333361050.0RepeatNote=RPEL 3
HgeneMKL2chr16:14234617chr16:14576684ENST00000318282+21640_6551.3333333333333361050.0RepeatNote=RPEL 1
HgeneMKL2chr16:14234617chr16:14576684ENST00000318282+21684_10951.3333333333333361050.0RepeatNote=RPEL 2
HgeneMKL2chr16:14234617chr16:14576684ENST00000341243+115128_1530.01089.0RepeatNote=RPEL 3
HgeneMKL2chr16:14234617chr16:14576684ENST00000341243+11540_650.01089.0RepeatNote=RPEL 1
HgeneMKL2chr16:14234617chr16:14576684ENST00000341243+11584_1090.01089.0RepeatNote=RPEL 2
HgeneMKL2chr16:14234617chr16:14576684ENST00000573051+19128_1530379.0RepeatNote=RPEL 3
HgeneMKL2chr16:14234617chr16:14576684ENST00000573051+1940_650379.0RepeatNote=RPEL 1
HgeneMKL2chr16:14234617chr16:14576684ENST00000573051+1984_1090379.0RepeatNote=RPEL 2
HgeneMKL2chr16:14234617chr16:14576684ENST00000574045+317128_15351.3333333333333361050.0RepeatNote=RPEL 3
HgeneMKL2chr16:14234617chr16:14576684ENST00000574045+31740_6551.3333333333333361050.0RepeatNote=RPEL 1
HgeneMKL2chr16:14234617chr16:14576684ENST00000574045+31784_10951.3333333333333361050.0RepeatNote=RPEL 2
TgenePARNchr16:14234617chr16:14576684ENST000003414842024178_245432.3333333333333579.0DomainR3H
TgenePARNchr16:14234617chr16:14576684ENST000004200151923178_245447.3333333333333594.0DomainR3H
TgenePARNchr16:14234617chr16:14576684ENST000004371982024178_245493.3333333333333640.0DomainR3H


Top

Fusion Gene Sequence for MKL2-PARN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000571589_ENST00000437198_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=1782nt_BP=326nt
ATCGCGCGGCGGCGGCGGGAGCGGCGGCGGCGGCGGCCGGGGAGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATA
ATTAAATATTCTTACCGAGTGTCTTCAATAGGCCGTGTTTAAGAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCA
CACAGGGGCGATAGACACCGAGGATGAAGTGGGACCTTTAGCCCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCA
GGAACTCTCCTTGCAGTCCAGTCAAAACTTACCCCCTCTGAACGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCG
GATCCAAACCTATGCTGAATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGA
CAGCAAACGGTTAAACCCCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGG
AAAGAGAAATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGA
TTCCTGTGCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTC
GAAGAACAGCCCTGCCACACTCTTTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGC
AAGAGCCGGCTGGCACATTTGGAAGCCGCACTGTATTTAACTTAATCAAATGTGGTATGGGAGGGGTTGGAAACCAAGTTGTCTCCTGGG
GGGGAGAAAACAGGTTTTATTTTTGTGGCTGTGGTTTTTTCCCCTTTTTAATCTAACTGCCTGTTGACATTGACACTCATCACGGTTGTA
GGCTGTCATGAATGTGTACGTGCTTAACCAGTGAATTCCGTGTTGCTCTTGTGAGGCCTTTCCTGTCATGACCCAGTGTGCTTAAGAACC
TGCCTGATGGGGAGTGTCGGCTGTGAAATCTGCAAAAAGAGCTGACATTCCAGCTGCTGTGATCATGAATTTGGGGGTGTACTGTCCTGC
CTGTGCATCTTCTCGCACTGAGATTTTGAGGCAGTTGCAGCCCTCGGTTAGTCTCCCAGTGGAAAAATCGGTTGTGCCTCCCTGCTTCCC
ACCATAGCTGCCTGAAAACATGACGCTCTCAAGCTTGTCCTTCCTTCAGGAAGATGTCCACTCATGCCCACCCATGAGAGGGCTTGCCGT
ATGCCCTGGCCTTTGGGCATATTTATGTAGAGTTCCTTTCTCCTAAGACGTGAGTTTCTCATGGGGGATGTACGAGTAAAAAGGTTAACT
TCTGTTCTTATGCGTGGCGCTGTGTTCACTTTCCAGAGTCTCTGTTCGTTTGTTTGGATGGCGGTCTCGGGGTACGGCAGCGTGTGTGCG
TACGTGTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAATCGTGCAAATCTACAACATGTCCCAGCCCAT
TCTCCGTTGAAACAGATCACAGCAACGACAAACGCTCATGGCGCTGCTTTGCTCCACCCGCTTCAGATAGATCATTGTTAGATATTTCAC

>In-frame_ENST00000571589_ENST00000437198_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=172_stop in transcript=765
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------
>In-frame_ENST00000571589_ENST00000420015_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=1210nt_BP=326nt
ATCGCGCGGCGGCGGCGGGAGCGGCGGCGGCGGCGGCCGGGGAGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATA
ATTAAATATTCTTACCGAGTGTCTTCAATAGGCCGTGTTTAAGAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCA
CACAGGGGCGATAGACACCGAGGATGAAGTGGGACCTTTAGCCCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCA
GGAACTCTCCTTGCAGTCCAGTCAAAACTTACCCCCTCTGAACGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCG
GATCCAAACCTATGCTGAATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGA
CAGCAAACGGTTAAACCCCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGG
AAAGAGAAATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGA
TTCCTGTGCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTC
GAAGAACAGCCCTGCCACACTCTTTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGC
AAGAGCCGGCTGGCACATTTGGAAGCCGCACTGTATTTAACTTAATCAAATGTGGTATGGGAGGGGTTGGAAACCAAGTTGTCTCCTGGG
GGGGAGAAAACAGGTTTTATTTTTGTGGCTGTGGTTTTTTCCCCTTTTTAATCTAACTGCCTGTTGACATTGACACTCATCACGGTTGTA
GGCTGTCATGAATGTGTACGTGCTTAACCAGTGAATTCCGTGTTGCTCTTGTGAGGCCTTTCCTGTCATGACCCAGTGTGCTTAAGAACC
TGCCTGATGGGGAGTGTCGGCTGTGAAATCTGCAAAAAGAGCTGACATTCCAGCTGCTGTGATCATGAATTTGGGGGTGTACTGTCCTGC

>In-frame_ENST00000571589_ENST00000420015_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=172_stop in transcript=765
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------
>In-frame_ENST00000571589_ENST00000341484_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=878nt_BP=326nt
ATCGCGCGGCGGCGGCGGGAGCGGCGGCGGCGGCGGCCGGGGAGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATA
ATTAAATATTCTTACCGAGTGTCTTCAATAGGCCGTGTTTAAGAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCA
CACAGGGGCGATAGACACCGAGGATGAAGTGGGACCTTTAGCCCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCA
GGAACTCTCCTTGCAGTCCAGTCAAAACTTACCCCCTCTGAACGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCG
GATCCAAACCTATGCTGAATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGA
CAGCAAACGGTTAAACCCCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGG
AAAGAGAAATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGA
TTCCTGTGCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTC
GAAGAACAGCCCTGCCACACTCTTTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGC

>In-frame_ENST00000571589_ENST00000341484_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=172_stop in transcript=765
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------
>In-frame_ENST00000571589_ENST00000539279_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=815nt_BP=326nt
ATCGCGCGGCGGCGGCGGGAGCGGCGGCGGCGGCGGCCGGGGAGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATA
ATTAAATATTCTTACCGAGTGTCTTCAATAGGCCGTGTTTAAGAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCA
CACAGGGGCGATAGACACCGAGGATGAAGTGGGACCTTTAGCCCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCA
GGAACTCTCCTTGCAGTCCAGTCAAAACTTACCCCCTCTGAACGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCG
GATCCAAACCTATGCTGAATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGA
CAGCAAACGGTTAAACCCCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGG
AAAGAGAAATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGA
TTCCTGTGCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTC
GAAGAACAGCCCTGCCACACTCTTTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGC

>In-frame_ENST00000571589_ENST00000539279_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=172_stop in transcript=765
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------
>In-frame_ENST00000574045_ENST00000437198_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=1765nt_BP=309nt
GGAGCGGCGGCGGCGGCGGCCGGGGAGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATAATTAAATATTCTTACCG
AGTGTCTTCAATAGGCCGTGTTTAAGAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCACACAGGGGCGATAGACA
CCGAGGATGAAGTGGGACCTTTAGCCCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCAGGAACTCTCCTTGCAGT
CCAGTCAAAACTTACCCCCTCTGAACGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTG
AATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACC
CCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTC
CTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCC
TCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCA
CACTCTTTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCCGGCTGGCACA
TTTGGAAGCCGCACTGTATTTAACTTAATCAAATGTGGTATGGGAGGGGTTGGAAACCAAGTTGTCTCCTGGGGGGGAGAAAACAGGTTT
TATTTTTGTGGCTGTGGTTTTTTCCCCTTTTTAATCTAACTGCCTGTTGACATTGACACTCATCACGGTTGTAGGCTGTCATGAATGTGT
ACGTGCTTAACCAGTGAATTCCGTGTTGCTCTTGTGAGGCCTTTCCTGTCATGACCCAGTGTGCTTAAGAACCTGCCTGATGGGGAGTGT
CGGCTGTGAAATCTGCAAAAAGAGCTGACATTCCAGCTGCTGTGATCATGAATTTGGGGGTGTACTGTCCTGCCTGTGCATCTTCTCGCA
CTGAGATTTTGAGGCAGTTGCAGCCCTCGGTTAGTCTCCCAGTGGAAAAATCGGTTGTGCCTCCCTGCTTCCCACCATAGCTGCCTGAAA
ACATGACGCTCTCAAGCTTGTCCTTCCTTCAGGAAGATGTCCACTCATGCCCACCCATGAGAGGGCTTGCCGTATGCCCTGGCCTTTGGG
CATATTTATGTAGAGTTCCTTTCTCCTAAGACGTGAGTTTCTCATGGGGGATGTACGAGTAAAAAGGTTAACTTCTGTTCTTATGCGTGG
CGCTGTGTTCACTTTCCAGAGTCTCTGTTCGTTTGTTTGGATGGCGGTCTCGGGGTACGGCAGCGTGTGTGCGTACGTGTCTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAATCGTGCAAATCTACAACATGTCCCAGCCCATTCTCCGTTGAAACAGAT
CACAGCAACGACAAACGCTCATGGCGCTGCTTTGCTCCACCCGCTTCAGATAGATCATTGTTAGATATTTCACATTTTTGTATGGTGGAA

>In-frame_ENST00000574045_ENST00000437198_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=155_stop in transcript=748
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------
>In-frame_ENST00000574045_ENST00000420015_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=1193nt_BP=309nt
GGAGCGGCGGCGGCGGCGGCCGGGGAGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATAATTAAATATTCTTACCG
AGTGTCTTCAATAGGCCGTGTTTAAGAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCACACAGGGGCGATAGACA
CCGAGGATGAAGTGGGACCTTTAGCCCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCAGGAACTCTCCTTGCAGT
CCAGTCAAAACTTACCCCCTCTGAACGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTG
AATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACC
CCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTC
CTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCC
TCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCA
CACTCTTTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCCGGCTGGCACA
TTTGGAAGCCGCACTGTATTTAACTTAATCAAATGTGGTATGGGAGGGGTTGGAAACCAAGTTGTCTCCTGGGGGGGAGAAAACAGGTTT
TATTTTTGTGGCTGTGGTTTTTTCCCCTTTTTAATCTAACTGCCTGTTGACATTGACACTCATCACGGTTGTAGGCTGTCATGAATGTGT
ACGTGCTTAACCAGTGAATTCCGTGTTGCTCTTGTGAGGCCTTTCCTGTCATGACCCAGTGTGCTTAAGAACCTGCCTGATGGGGAGTGT
CGGCTGTGAAATCTGCAAAAAGAGCTGACATTCCAGCTGCTGTGATCATGAATTTGGGGGTGTACTGTCCTGCCTGTGCATCTTCTCGCA

>In-frame_ENST00000574045_ENST00000420015_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=155_stop in transcript=748
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------
>In-frame_ENST00000574045_ENST00000341484_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=861nt_BP=309nt
GGAGCGGCGGCGGCGGCGGCCGGGGAGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATAATTAAATATTCTTACCG
AGTGTCTTCAATAGGCCGTGTTTAAGAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCACACAGGGGCGATAGACA
CCGAGGATGAAGTGGGACCTTTAGCCCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCAGGAACTCTCCTTGCAGT
CCAGTCAAAACTTACCCCCTCTGAACGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTG
AATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACC
CCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTC
CTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCC
TCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCA
CACTCTTTGAAGTTCCTGACACATGGTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCCGGCTGGCACA

>In-frame_ENST00000574045_ENST00000341484_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=155_stop in transcript=748
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------
>In-frame_ENST00000574045_ENST00000539279_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=798nt_BP=309nt
GGAGCGGCGGCGGCGGCGGCCGGGGAGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATAATTAAATATTCTTACCG
AGTGTCTTCAATAGGCCGTGTTTAAGAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCACACAGGGGCGATAGACA
CCGAGGATGAAGTGGGACCTTTAGCCCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCAGGAACTCTCCTTGCAGT
CCAGTCAAAACTTACCCCCTCTGAACGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTG
AATATATGGGGAGAAAACAGGAAGAGAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACC
CCCAGTGCATACCCTACACCCTGCAGAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTC
CTAGTCAAGAGGAAGCTGGCCTGGAGGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCC
TCTCAGAGGGAAGGAAAAAGGCCAAGAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCA

>In-frame_ENST00000574045_ENST00000539279_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=155_stop in transcript=748
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------
>In-frame_ENST00000318282_ENST00000437198_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=1740nt_BP=284nt
AGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATAATTAAATATTCTTACCGAGTGTCTTCAATAGGCCGTGTTTAA
GAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCACACAGGGGCGATAGACACCGAGGATGAAGTGGGACCTTTAGC
CCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCAGGAACTCTCCTTGCAGTCCAGTCAAAACTTACCCCCTCTGAA
CGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTGAATATATGGGGAGAAAACAGGAAGA
GAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACCCCCAGTGCATACCCTACACCCTGCA
GAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGA
GGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAA
GAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCACACTCTTTGAAGTTCCTGACACATG
GTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCCGGCTGGCACATTTGGAAGCCGCACTGTATTTAACT
TAATCAAATGTGGTATGGGAGGGGTTGGAAACCAAGTTGTCTCCTGGGGGGGAGAAAACAGGTTTTATTTTTGTGGCTGTGGTTTTTTCC
CCTTTTTAATCTAACTGCCTGTTGACATTGACACTCATCACGGTTGTAGGCTGTCATGAATGTGTACGTGCTTAACCAGTGAATTCCGTG
TTGCTCTTGTGAGGCCTTTCCTGTCATGACCCAGTGTGCTTAAGAACCTGCCTGATGGGGAGTGTCGGCTGTGAAATCTGCAAAAAGAGC
TGACATTCCAGCTGCTGTGATCATGAATTTGGGGGTGTACTGTCCTGCCTGTGCATCTTCTCGCACTGAGATTTTGAGGCAGTTGCAGCC
CTCGGTTAGTCTCCCAGTGGAAAAATCGGTTGTGCCTCCCTGCTTCCCACCATAGCTGCCTGAAAACATGACGCTCTCAAGCTTGTCCTT
CCTTCAGGAAGATGTCCACTCATGCCCACCCATGAGAGGGCTTGCCGTATGCCCTGGCCTTTGGGCATATTTATGTAGAGTTCCTTTCTC
CTAAGACGTGAGTTTCTCATGGGGGATGTACGAGTAAAAAGGTTAACTTCTGTTCTTATGCGTGGCGCTGTGTTCACTTTCCAGAGTCTC
TGTTCGTTTGTTTGGATGGCGGTCTCGGGGTACGGCAGCGTGTGTGCGTACGTGTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGAAATCGTGCAAATCTACAACATGTCCCAGCCCATTCTCCGTTGAAACAGATCACAGCAACGACAAACGCTCATGGC
GCTGCTTTGCTCCACCCGCTTCAGATAGATCATTGTTAGATATTTCACATTTTTGTATGGTGGAAATAAAAATGAAAAATGTATTTCCAA

>In-frame_ENST00000318282_ENST00000437198_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=130_stop in transcript=723
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------
>In-frame_ENST00000318282_ENST00000420015_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=1168nt_BP=284nt
AGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATAATTAAATATTCTTACCGAGTGTCTTCAATAGGCCGTGTTTAA
GAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCACACAGGGGCGATAGACACCGAGGATGAAGTGGGACCTTTAGC
CCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCAGGAACTCTCCTTGCAGTCCAGTCAAAACTTACCCCCTCTGAA
CGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTGAATATATGGGGAGAAAACAGGAAGA
GAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACCCCCAGTGCATACCCTACACCCTGCA
GAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGA
GGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAA
GAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCACACTCTTTGAAGTTCCTGACACATG
GTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCCGGCTGGCACATTTGGAAGCCGCACTGTATTTAACT
TAATCAAATGTGGTATGGGAGGGGTTGGAAACCAAGTTGTCTCCTGGGGGGGAGAAAACAGGTTTTATTTTTGTGGCTGTGGTTTTTTCC
CCTTTTTAATCTAACTGCCTGTTGACATTGACACTCATCACGGTTGTAGGCTGTCATGAATGTGTACGTGCTTAACCAGTGAATTCCGTG
TTGCTCTTGTGAGGCCTTTCCTGTCATGACCCAGTGTGCTTAAGAACCTGCCTGATGGGGAGTGTCGGCTGTGAAATCTGCAAAAAGAGC

>In-frame_ENST00000318282_ENST00000420015_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=130_stop in transcript=723
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------
>In-frame_ENST00000318282_ENST00000341484_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=836nt_BP=284nt
AGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATAATTAAATATTCTTACCGAGTGTCTTCAATAGGCCGTGTTTAA
GAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCACACAGGGGCGATAGACACCGAGGATGAAGTGGGACCTTTAGC
CCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCAGGAACTCTCCTTGCAGTCCAGTCAAAACTTACCCCCTCTGAA
CGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTGAATATATGGGGAGAAAACAGGAAGA
GAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACCCCCAGTGCATACCCTACACCCTGCA
GAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGA
GGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAA
GAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCACACTCTTTGAAGTTCCTGACACATG
GTAACCAAGACCTGAGGGCAGCAAACCGCTGGTGCTGTCGCTGTGAGCAAGAGCCGGCTGGCACATTTGGAAGCCGCACTGTATTTAACT

>In-frame_ENST00000318282_ENST00000341484_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=130_stop in transcript=723
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------
>In-frame_ENST00000318282_ENST00000539279_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(transcript)=773nt_BP=284nt
AGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATAATTAAATATTCTTACCGAGTGTCTTCAATAGGCCGTGTTTAA
GAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCACACAGGGGCGATAGACACCGAGGATGAAGTGGGACCTTTAGC
CCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCAGGAACTCTCCTTGCAGTCCAGTCAAAACTTACCCCCTCTGAA
CGAAAGGAAAAATGCTGTCAATACCAGCAAATATGCAGAAAGCTATCGGATCCAAACCTATGCTGAATATATGGGGAGAAAACAGGAAGA
GAAGCAGATCAAAAGAAAGTGGACTGAAGATAGCTGGAAGGAGGCTGACAGCAAACGGTTAAACCCCCAGTGCATACCCTACACCCTGCA
GAATCACTATTACCGCAACAATAGTTTTACAGCTCCCAGCACAGTAGGAAAGAGAAATTTGAGTCCTAGTCAAGAGGAAGCTGGCCTGGA
GGACGGAGTGTCAGGGGAGATTTCCGACACTGAGCTTGAGCAGACCGATTCCTGTGCAGAGCCCCTCTCAGAGGGAAGGAAAAAGGCCAA
GAAATTAAAAAGAATGAAGAAGGAGCTTTCTCCAGCAGGAAGCATCTCGAAGAACAGCCCTGCCACACTCTTTGAAGTTCCTGACACATG

>In-frame_ENST00000318282_ENST00000539279_TCGA-HZ-8519_MKL2_chr16_14234617_+_PARN_chr16_14576684_length(amino acids)=197AA_start in transcript=130_stop in transcript=723
MDHTGAIDTEDEVGPLAHLAPSPQSEAVAHEFQELSLQSSQNLPPLNERKNAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWK
EADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MKL2-PARN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MKL2-PARN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MKL2-PARN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePARNC4225347PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 44CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePARNC4225356DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 63CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePARNC0265965Dyskeratosis Congenita2GENOMICS_ENGLAND;ORPHANET
TgenePARNC0085786Hamman-Rich syndrome1ORPHANET
TgenePARNC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET
TgenePARNC1846142HOYERAAL-HREIDARSSON SYNDROME1ORPHANET
TgenePARNC4721508Hamman-Rich Disease1CTD_human
TgenePARNC4721509Usual Interstitial Pneumonia1CTD_human
TgenePARNC4721952Familial Idiopathic Pulmonary Fibrosis1CTD_human