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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MLLT4-GMDS (FusionGDB2 ID:53985)

Fusion Gene Summary for MLLT4-GMDS

check button Fusion gene summary
Fusion gene informationFusion gene name: MLLT4-GMDS
Fusion gene ID: 53985
HgeneTgene
Gene symbol

MLLT4

GMDS

Gene ID

4301

2762

Gene nameafadin, adherens junction formation factorGDP-mannose 4,6-dehydratase
SynonymsAF6|MLL-AF6|MLLT4|l-afadinGMD|SDR3E1
Cytomap

6q27

6p25.3

Type of geneprotein-codingprotein-coding
DescriptionafadinALL1-fused gene from chromosome 6 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4protein AF-6GDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1
Modification date2020032220200313
UniProtAcc.

O60547

Ensembl transtripts involved in fusion geneENST00000344191, ENST00000351017, 
ENST00000392108, ENST00000392112, 
ENST00000366806, ENST00000447894, 
ENST00000400822, ENST00000507679, 
ENST00000530927, ENST00000380815, 
ENST00000467288, 
Fusion gene scores* DoF score15 X 7 X 10=105014 X 10 X 8=1120
# samples 1615
** MAII scorelog2(16/1050*10)=-2.71424551766612
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1120*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MLLT4 [Title/Abstract] AND GMDS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMLLT4(168227917)-GMDS(1742820), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGMDS

GO:0019673

GDP-mannose metabolic process

9525924

TgeneGMDS

GO:0042351

'de novo' GDP-L-fucose biosynthetic process

9525924


check buttonFusion gene breakpoints across MLLT4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GMDS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-98-8023-01AMLLT4chr6

168227917

-GMDSchr6

1742820

-


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Fusion Gene ORF analysis for MLLT4-GMDS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344191ENST00000530927MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000344191ENST00000380815MLLT4chr6

168227917

-GMDSchr6

1742820

-
5CDS-intronENST00000344191ENST00000467288MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000351017ENST00000530927MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000351017ENST00000380815MLLT4chr6

168227917

-GMDSchr6

1742820

-
5CDS-intronENST00000351017ENST00000467288MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000392108ENST00000530927MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000392108ENST00000380815MLLT4chr6

168227917

-GMDSchr6

1742820

-
5CDS-intronENST00000392108ENST00000467288MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000392112ENST00000530927MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000392112ENST00000380815MLLT4chr6

168227917

-GMDSchr6

1742820

-
5CDS-intronENST00000392112ENST00000467288MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000366806ENST00000530927MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000366806ENST00000380815MLLT4chr6

168227917

-GMDSchr6

1742820

-
5CDS-intronENST00000366806ENST00000467288MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000447894ENST00000530927MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000447894ENST00000380815MLLT4chr6

168227917

-GMDSchr6

1742820

-
5CDS-intronENST00000447894ENST00000467288MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000400822ENST00000530927MLLT4chr6

168227917

-GMDSchr6

1742820

-
In-frameENST00000400822ENST00000380815MLLT4chr6

168227917

-GMDSchr6

1742820

-
5CDS-intronENST00000400822ENST00000467288MLLT4chr6

168227917

-GMDSchr6

1742820

-
intron-3CDSENST00000507679ENST00000530927MLLT4chr6

168227917

-GMDSchr6

1742820

-
intron-3CDSENST00000507679ENST00000380815MLLT4chr6

168227917

-GMDSchr6

1742820

-
intron-intronENST00000507679ENST00000467288MLLT4chr6

168227917

-GMDSchr6

1742820

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344191MLLT4chr6168227917-ENST00000530927GMDSchr61742820-988277873367168
ENST00000344191MLLT4chr6168227917-ENST00000380815GMDSchr61742820-988277873367168
ENST00000351017MLLT4chr6168227917-ENST00000530927GMDSchr61742820-988277873367168
ENST00000351017MLLT4chr6168227917-ENST00000380815GMDSchr61742820-988277873367168
ENST00000392108MLLT4chr6168227917-ENST00000530927GMDSchr61742820-958247843337168
ENST00000392108MLLT4chr6168227917-ENST00000380815GMDSchr61742820-958247843337168
ENST00000392112MLLT4chr6168227917-ENST00000530927GMDSchr61742820-958247843337168
ENST00000392112MLLT4chr6168227917-ENST00000380815GMDSchr61742820-958247843337168
ENST00000366806MLLT4chr6168227917-ENST00000530927GMDSchr61742820-958247843337168
ENST00000366806MLLT4chr6168227917-ENST00000380815GMDSchr61742820-958247843337168
ENST00000447894MLLT4chr6168227917-ENST00000530927GMDSchr61742820-816105701195168
ENST00000447894MLLT4chr6168227917-ENST00000380815GMDSchr61742820-816105701195168
ENST00000400822MLLT4chr6168227917-ENST00000530927GMDSchr61742820-816105701195168
ENST00000400822MLLT4chr6168227917-ENST00000380815GMDSchr61742820-816105701195168

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344191ENST00000530927MLLT4chr6168227917-GMDSchr61742820-0.0036426370.9963574
ENST00000344191ENST00000380815MLLT4chr6168227917-GMDSchr61742820-0.0036426370.9963574
ENST00000351017ENST00000530927MLLT4chr6168227917-GMDSchr61742820-0.0036426370.9963574
ENST00000351017ENST00000380815MLLT4chr6168227917-GMDSchr61742820-0.0036426370.9963574
ENST00000392108ENST00000530927MLLT4chr6168227917-GMDSchr61742820-0.0042582330.99574184
ENST00000392108ENST00000380815MLLT4chr6168227917-GMDSchr61742820-0.0042582330.99574184
ENST00000392112ENST00000530927MLLT4chr6168227917-GMDSchr61742820-0.0042582330.99574184
ENST00000392112ENST00000380815MLLT4chr6168227917-GMDSchr61742820-0.0042582330.99574184
ENST00000366806ENST00000530927MLLT4chr6168227917-GMDSchr61742820-0.0042582330.99574184
ENST00000366806ENST00000380815MLLT4chr6168227917-GMDSchr61742820-0.0042582330.99574184
ENST00000447894ENST00000530927MLLT4chr6168227917-GMDSchr61742820-0.0044379470.9955621
ENST00000447894ENST00000380815MLLT4chr6168227917-GMDSchr61742820-0.0044379470.9955621
ENST00000400822ENST00000530927MLLT4chr6168227917-GMDSchr61742820-0.0044379470.9955621
ENST00000400822ENST00000380815MLLT4chr6168227917-GMDSchr61742820-0.0044379470.9955621

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Fusion Genomic Features for MLLT4-GMDS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MLLT4-GMDS


check button Go to

FGviewer for the breakpoints of chr6:168227917-chr6:1742820

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GMDS

O60547

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. {ECO:0000269|PubMed:9525924}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-1301408_144835.01652.0Coiled coilOntology_term=ECO:0000255
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-130146_18535.01652.0Coiled coilOntology_term=ECO:0000255
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-1301523_166735.01652.0Coiled coilOntology_term=ECO:0000255
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-1341408_144835.01835.0Coiled coilOntology_term=ECO:0000255
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-134146_18535.01835.0Coiled coilOntology_term=ECO:0000255
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-1341523_166735.01835.0Coiled coilOntology_term=ECO:0000255
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-1331408_144835.01825.0Coiled coilOntology_term=ECO:0000255
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-133146_18535.01825.0Coiled coilOntology_term=ECO:0000255
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-1331523_166735.01825.0Coiled coilOntology_term=ECO:0000255
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-1301346_139235.01652.0Compositional biasNote=Pro-rich
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-1301578_158835.01652.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-130163_17535.01652.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-1301678_170835.01652.0Compositional biasNote=Pro-rich
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-1341346_139235.01835.0Compositional biasNote=Pro-rich
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-1341578_158835.01835.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-134163_17535.01835.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-1341678_170835.01835.0Compositional biasNote=Pro-rich
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-1331346_139235.01825.0Compositional biasNote=Pro-rich
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-1331578_158835.01825.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-133163_17535.01825.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-1331678_170835.01825.0Compositional biasNote=Pro-rich
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-1301007_109335.01652.0DomainPDZ
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-130246_34835.01652.0DomainRas-associating 2
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-13039_13335.01652.0DomainRas-associating 1
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-130426_49235.01652.0DomainNote=FHA
HgeneMLLT4chr6:168227917chr6:1742820ENST00000392108-130668_90835.01652.0DomainDilute
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-1341007_109335.01835.0DomainPDZ
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-134246_34835.01835.0DomainRas-associating 2
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-13439_13335.01835.0DomainRas-associating 1
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-134426_49235.01835.0DomainNote=FHA
HgeneMLLT4chr6:168227917chr6:1742820ENST00000400822-134668_90835.01835.0DomainDilute
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-1331007_109335.01825.0DomainPDZ
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-133246_34835.01825.0DomainRas-associating 2
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-13339_13335.01825.0DomainRas-associating 1
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-133426_49235.01825.0DomainNote=FHA
HgeneMLLT4chr6:168227917chr6:1742820ENST00000447894-133668_90835.01825.0DomainDilute
TgeneGMDSchr6:168227917chr6:1742820ENST00000380815611108_112257.0373.0Nucleotide bindingNADP
TgeneGMDSchr6:168227917chr6:1742820ENST0000038081561130_35257.0373.0Nucleotide bindingNADP
TgeneGMDSchr6:168227917chr6:1742820ENST0000038081561155_58257.0373.0Nucleotide bindingNADP
TgeneGMDSchr6:168227917chr6:1742820ENST0000038081561186_87257.0373.0Nucleotide bindingNADP
TgeneGMDSchr6:168227917chr6:1742820ENST00000530927611108_112227.0343.0Nucleotide bindingNADP
TgeneGMDSchr6:168227917chr6:1742820ENST0000053092761130_35227.0343.0Nucleotide bindingNADP
TgeneGMDSchr6:168227917chr6:1742820ENST0000053092761155_58227.0343.0Nucleotide bindingNADP
TgeneGMDSchr6:168227917chr6:1742820ENST0000053092761186_87227.0343.0Nucleotide bindingNADP


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Fusion Gene Sequence for MLLT4-GMDS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000344191_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=988nt_BP=277nt
CCAGGCGGAGGCCAAGTCGGAGGACGCGGCGCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGG
GCGCCGGGCCCCCGCGGACCTGTCGTCCTCGGCCCGTCCTCCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGC
GGGCGGCCGTGACGAGGAGCGGCGGAAGCTGGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCC
GACCGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGT
CGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGT
TCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTG
GAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGC
GCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCT
GCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGA
CCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACT

>In-frame_ENST00000344191_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=873_stop in transcript=367
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000344191_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=988nt_BP=277nt
CCAGGCGGAGGCCAAGTCGGAGGACGCGGCGCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGG
GCGCCGGGCCCCCGCGGACCTGTCGTCCTCGGCCCGTCCTCCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGC
GGGCGGCCGTGACGAGGAGCGGCGGAAGCTGGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCC
GACCGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGT
CGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGT
TCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTG
GAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGC
GCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCT
GCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGA
CCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACT

>In-frame_ENST00000344191_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=873_stop in transcript=367
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000351017_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=988nt_BP=277nt
CCAGGCGGAGGCCAAGTCGGAGGACGCGGCGCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGG
GCGCCGGGCCCCCGCGGACCTGTCGTCCTCGGCCCGTCCTCCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGC
GGGCGGCCGTGACGAGGAGCGGCGGAAGCTGGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCC
GACCGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGT
CGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGT
TCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTG
GAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGC
GCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCT
GCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGA
CCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACT

>In-frame_ENST00000351017_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=873_stop in transcript=367
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000351017_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=988nt_BP=277nt
CCAGGCGGAGGCCAAGTCGGAGGACGCGGCGCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGG
GCGCCGGGCCCCCGCGGACCTGTCGTCCTCGGCCCGTCCTCCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGC
GGGCGGCCGTGACGAGGAGCGGCGGAAGCTGGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCC
GACCGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGT
CGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGT
TCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTG
GAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGC
GCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCT
GCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGA
CCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACT

>In-frame_ENST00000351017_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=873_stop in transcript=367
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000392108_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=958nt_BP=247nt
GCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGGGCGCCGGGCCCCCGCGGACCTGTCGTCCTC
GGCCCGTCCTCCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCT
GGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCCGACCGAGGCTATGTGGTTGATGTTGCAGAA
TGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAAC
CATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCG
GCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGT
GAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTAC
AATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTG
CGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTG
TCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGTG

>In-frame_ENST00000392108_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=843_stop in transcript=337
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000392108_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=958nt_BP=247nt
GCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGGGCGCCGGGCCCCCGCGGACCTGTCGTCCTC
GGCCCGTCCTCCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCT
GGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCCGACCGAGGCTATGTGGTTGATGTTGCAGAA
TGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAAC
CATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCG
GCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGT
GAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTAC
AATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTG
CGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTG
TCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGTG

>In-frame_ENST00000392108_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=843_stop in transcript=337
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000392112_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=958nt_BP=247nt
GCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGGGCGCCGGGCCCCCGCGGACCTGTCGTCCTC
GGCCCGTCCTCCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCT
GGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCCGACCGAGGCTATGTGGTTGATGTTGCAGAA
TGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAAC
CATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCG
GCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGT
GAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTAC
AATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTG
CGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTG
TCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGTG

>In-frame_ENST00000392112_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=843_stop in transcript=337
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000392112_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=958nt_BP=247nt
GCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGGGCGCCGGGCCCCCGCGGACCTGTCGTCCTC
GGCCCGTCCTCCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCT
GGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCCGACCGAGGCTATGTGGTTGATGTTGCAGAA
TGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAAC
CATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCG
GCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGT
GAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTAC
AATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTG
CGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTG
TCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGTG

>In-frame_ENST00000392112_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=843_stop in transcript=337
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000366806_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=958nt_BP=247nt
GCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGGGCGCCGGGCCCCCGCGGACCTGTCGTCCTC
GGCCCGTCCTCCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCT
GGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCCGACCGAGGCTATGTGGTTGATGTTGCAGAA
TGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAAC
CATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCG
GCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGT
GAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTAC
AATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTG
CGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTG
TCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGTG

>In-frame_ENST00000366806_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=843_stop in transcript=337
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000366806_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=958nt_BP=247nt
GCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGGGCGCCGGGCCCCCGCGGACCTGTCGTCCTC
GGCCCGTCCTCCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCT
GGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCCGACCGAGGCTATGTGGTTGATGTTGCAGAA
TGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAAC
CATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCG
GCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGT
GAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTAC
AATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTG
CGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTG
TCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGTG

>In-frame_ENST00000366806_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=843_stop in transcript=337
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000447894_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=816nt_BP=105nt
ATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCTGGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATC
AGCCAGCCGACCGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGG
GAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACC
GGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAG
CTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCC
TGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGT
GCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCG
GGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTC
ACTTTACTTGAAATTATGTTGTTACACAACAAATTGTGGGGCCTTCAAATTGTTTTTCTCTTTTCATATTAAAAATGGTCTTTCTGTGAA

>In-frame_ENST00000447894_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=701_stop in transcript=195
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000447894_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=816nt_BP=105nt
ATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCTGGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATC
AGCCAGCCGACCGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGG
GAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACC
GGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAG
CTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCC
TGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGT
GCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCG
GGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTC
ACTTTACTTGAAATTATGTTGTTACACAACAAATTGTGGGGCCTTCAAATTGTTTTTCTCTTTTCATATTAAAAATGGTCTTTCTGTGAA

>In-frame_ENST00000447894_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=701_stop in transcript=195
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000400822_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=816nt_BP=105nt
ATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCTGGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATC
AGCCAGCCGACCGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGG
GAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACC
GGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAG
CTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCC
TGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGT
GCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCG
GGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTC
ACTTTACTTGAAATTATGTTGTTACACAACAAATTGTGGGGCCTTCAAATTGTTTTTCTCTTTTCATATTAAAAATGGTCTTTCTGTGAA

>In-frame_ENST00000400822_ENST00000530927_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=701_stop in transcript=195
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------
>In-frame_ENST00000400822_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(transcript)=816nt_BP=105nt
ATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCTGGCCGACATCATCCACCACTGGAACGCCAACCGGCTGGACCTGTTCGAGATC
AGCCAGCCGACCGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGG
GAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACC
GGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAG
CTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCC
TGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGT
GCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCG
GGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTC
ACTTTACTTGAAATTATGTTGTTACACAACAAATTGTGGGGCCTTCAAATTGTTTTTCTCTTTTCATATTAAAAATGGTCTTTCTGTGAA

>In-frame_ENST00000400822_ENST00000380815_TCGA-98-8023-01A_MLLT4_chr6_168227917_-_GMDS_chr6_1742820_length(amino acids)=168AA_start in transcript=701_stop in transcript=195
MISQSHSEEASTNAKRPKPWRVTSRLLQTSAGRPRSCGRDSAAAAGAAGDPQIGTPLPIPAARLHRRLCGDCSRRAGRAPRRCSGIGVCP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MLLT4-GMDS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MLLT4-GMDS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MLLT4-GMDS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource