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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MMP14-CCT5 (FusionGDB2 ID:54079)

Fusion Gene Summary for MMP14-CCT5

check button Fusion gene summary
Fusion gene informationFusion gene name: MMP14-CCT5
Fusion gene ID: 54079
HgeneTgene
Gene symbol

MMP14

CCT5

Gene ID

4323

22948

Gene namematrix metallopeptidase 14chaperonin containing TCP1 subunit 5
SynonymsMMP-14|MMP-X1|MT-MMP|MT-MMP 1|MT1-MMP|MT1MMP|MTMMP1|WNCHRSCCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon
Cytomap

14q11.2

5p15.2

Type of geneprotein-codingprotein-coding
Descriptionmatrix metalloproteinase-14matrix metallopeptidase 14 (membrane-inserted)membrane type 1 metalloproteasemembrane-type-1 matrix metalloproteinaseT-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
Modification date2020032920200313
UniProtAcc.

P48643

Ensembl transtripts involved in fusion geneENST00000311852, ENST00000548162, 
ENST00000280326, ENST00000503026, 
ENST00000515390, ENST00000515676, 
ENST00000506600, 
Fusion gene scores* DoF score7 X 6 X 5=21058 X 14 X 17=13804
# samples 761
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(61/13804*10)=-4.50013332598527
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MMP14 [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMMP14(23316970)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMMP14

GO:0006508

proteolysis

15863497|24970228

HgeneMMP14

GO:0030307

positive regulation of cell growth

22065321

HgeneMMP14

GO:0030335

positive regulation of cell migration

22065321

HgeneMMP14

GO:0031638

zymogen activation

20666777


check buttonFusion gene breakpoints across MMP14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IW-A3M6-01AMMP14chr14

23316970

-CCT5chr5

10250033

+


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Fusion Gene ORF analysis for MMP14-CCT5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000311852ENST00000280326MMP14chr14

23316970

-CCT5chr5

10250033

+
5CDS-intronENST00000311852ENST00000503026MMP14chr14

23316970

-CCT5chr5

10250033

+
5CDS-intronENST00000311852ENST00000515390MMP14chr14

23316970

-CCT5chr5

10250033

+
5CDS-intronENST00000311852ENST00000515676MMP14chr14

23316970

-CCT5chr5

10250033

+
5CDS-intronENST00000311852ENST00000506600MMP14chr14

23316970

-CCT5chr5

10250033

+
intron-3CDSENST00000548162ENST00000280326MMP14chr14

23316970

-CCT5chr5

10250033

+
intron-intronENST00000548162ENST00000503026MMP14chr14

23316970

-CCT5chr5

10250033

+
intron-intronENST00000548162ENST00000515390MMP14chr14

23316970

-CCT5chr5

10250033

+
intron-intronENST00000548162ENST00000515676MMP14chr14

23316970

-CCT5chr5

10250033

+
intron-intronENST00000548162ENST00000506600MMP14chr14

23316970

-CCT5chr5

10250033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311852MMP14chr1423316970-ENST00000280326CCT5chr510250033+740737322402009589

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311852ENST00000280326MMP14chr1423316970-CCT5chr510250033+0.0006830630.99931693

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Fusion Genomic Features for MMP14-CCT5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MMP14-CCT5


check button Go to

FGviewer for the breakpoints of chr14:23316970-chr5:10250033

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCT5

P48643

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMMP14chr14:23316970chr5:10250033ENST00000311852-101091_981157.0583.0MotifCysteine switch
HgeneMMP14chr14:23316970chr5:10250033ENST00000311852-1010316_3641157.0583.0RepeatNote=Hemopexin 1
HgeneMMP14chr14:23316970chr5:10250033ENST00000311852-1010365_4101157.0583.0RepeatNote=Hemopexin 2
HgeneMMP14chr14:23316970chr5:10250033ENST00000311852-1010412_4601157.0583.0RepeatNote=Hemopexin 3
HgeneMMP14chr14:23316970chr5:10250033ENST00000311852-1010461_5081157.0583.0RepeatNote=Hemopexin 4
HgeneMMP14chr14:23316970chr5:10250033ENST00000311852-1010112_5411157.0583.0Topological domainExtracellular
HgeneMMP14chr14:23316970chr5:10250033ENST00000311852-1010563_5821157.0583.0Topological domainCytoplasmic
HgeneMMP14chr14:23316970chr5:10250033ENST00000311852-1010542_5621157.0583.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MMP14-CCT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000311852_ENST00000280326_TCGA-IW-A3M6-01A_MMP14_chr14_23316970_-_CCT5_chr5_10250033_length(transcript)=7407nt_BP=3732nt
ACCAGAGGAGAGAGCGAGAGAGGGAACCAGACCCCAGTTCGCCGACTAAGCAGAAGAAAGATCAAAAACCGGAAAAGAGGAGAAGAGCAA
ACAGGCACTTTGAGGAACAATCCCCTTTAACTCCAAGCCGACAGCGGTCTAGGAATTCAAGTTCAGTGCCTACCGAAGACAAAGGCGCCC
CGAGGGAGTGGCGGTGCGACCCCAGGGCGTGGGCCCGGCCGCGGAGCCCACACTGCCCGGCTGACCCGGTGGTCTCGGACCATGTCTCCC
GCCCCAAGACCCCCCCGTTGTCTCCTGCTCCCCCTGCTCACGCTCGGCACCGCGCTCGCCTCCCTCGGCTCGGCCCAAAGCAGCAGCTTC
AGCCCCGAAGCCTGGCTACAGCAATATGGCTACCTGCCTCCCGGGGACCTACGTACCCACACACAGCGCTCACCCCAGTCACTCTCAGCG
GCCATCGCTGCCATGCAGAAGTTTTACGGCTTGCAAGTAACAGGCAAAGCTGATGCAGACACCATGAAGGCCATGAGGCGCCCCCGATGT
GGTGTTCCAGACAAGTTTGGGGCTGAGATCAAGGCCAATGTTCGAAGGAAGCGCTACGCCATCCAGGGTCTCAAATGGCAACATAATGAA
ATCACTTTCTGCATCCAGAATTACACCCCCAAGGTGGGCGAGTATGCCACATACGAGGCCATTCGCAAGGCGTTCCGCGTGTGGGAGAGT
GCCACACCACTGCGCTTCCGCGAGGTGCCCTATGCCTACATCCGTGAGGGCCATGAGAAGCAGGCCGACATCATGATCTTCTTTGCCGAG
GGCTTCCATGGCGACAGCACGCCCTTCGATGGTGAGGGCGGCTTCCTGGCCCATGCCTACTTCCCAGGCCCCAACATTGGAGGAGACACC
CACTTTGACTCTGCCGAGCCTTGGACTGTCAGGAATGAGGATCTGAATGGAAATGACATCTTCCTGGTGGCTGTGCACGAGCTGGGCCAT
GCCCTGGGGCTCGAGCATTCCAGTGACCCCTCGGCCATCATGGCACCCTTTTACCAGTGGATGGACACGGAGAATTTTGTGCTGCCCGAT
GATGACCGCCGGGGCATCCAGCAACTTTATGGGGGTGAGTCAGGGTTCCCCACCAAGATGCCCCCTCAACCCAGGACTACCTCCCGGCCT
TCTGTTCCTGATAAACCCAAAAACCCCACCTATGGGCCCAACATCTGTGACGGGAACTTTGACACCGTGGCCATGCTCCGAGGGGAGATG
TTTGTCTTCAAGGAGCGCTGGTTCTGGCGGGTGAGGAATAACCAAGTGATGGATGGATACCCAATGCCCATTGGCCAGTTCTGGCGGGGC
CTGCCTGCGTCCATCAACACTGCCTACGAGAGGAAGGATGGCAAATTCGTCTTCTTCAAAGGAGACAAGCATTGGGTGTTTGATGAGGCG
TCCCTGGAACCTGGCTACCCCAAGCACATTAAGGAGCTGGGCCGAGGGCTGCCTACCGACAAGATTGATGCTGCTCTCTTCTGGATGCCC
AATGGAAAGACCTACTTCTTCCGTGGAAACAAGTACTACCGTTTCAACGAAGAGCTCAGGGCAGTGGATAGCGAGTACCCCAAGAACATC
AAAGTCTGGGAAGGGATCCCTGAGTCTCCCAGAGGGTCATTCATGGGCAGCGATGAAGTCTTCACTTACTTCTACAAGGGGAACAAATAC
TGGAAATTCAACAACCAGAAGCTGAAGGTAGAACCGGGCTACCCCAAGTCAGCCCTGAGGGACTGGATGGGCTGCCCATCGGGAGGCCGG
CCGGATGAGGGGACTGAGGAGGAGACGGAGGTGATCATCATTGAGGTGGACGAGGAGGGCGGCGGGGCGGTGAGCGCGGCTGCCGTGGTG
CTGCCCGTGCTGCTGCTGCTCCTGGTGCTGGCGGTGGGCCTTGCAGTCTTCTTCTTCAGACGCCATGGGACCCCCAGGCGACTGCTCTAC
TGCCAGCGTTCCCTGCTGGACAAGGTCTGACGCCCACCGCCGGCCCGCCCACTCCTACCACAAGGACTTTGCCTCTGAAGGCCAGTGGCA
GCAGGTGGTGGTGGGTGGGCTGTTCCCATCGTCCCGAGCCCCCTCCCCGCAGCCTCCTTGCTTCTCTCTGTCCCCTGGCTGGCCTCCTTC
ACCCTGACCGCCTCCCTCCCTCCTGCCCCGGCATTGCATCTTCCCTAGATAGGTCCCCTGAGGGCTGAGTGGGAGGGCGGCCCTTTCCAG
CCTCTGCCCCTCAGGGGAACCCTGTAGCTTTGTGTCTGTCCAGCCCCATCTGAATGTGTTGGGGGCTCTGCACTTGAAGGCAGGACCCTC
AGACCTCGCTGGTAAAGGTCAAATGGGGTCATCTGCTCCTTTTCCATCCCCTGACATACCTTAACCTCTGAACTCTGACCTCAGGAGGCT
CTGGGCACTCCAGCCCTGAAAGCCCCAGGTGTACCCAATTGGCAGCCTCTCACTACTCTTTCTGGCTAAAAGGAATCTAATCTTGTTGAG
GGTAGAGACCCTGAGACAGTGTGAGGGGGTGGGGACTGCCAAGCCACCCTAAGACCTTGGGAGGAAAACTCAGAGAGGGTCTTCGTTGCT
CAGTCAGTCAAGTTCCTCGGAGATCTGCCTCTGCCTCACCTACCCCAGGGAACTTCCAAGGAAGGAGCCTGAGCCACTGGGGACTAAGTG
GGCAGAAGAAACCCTTGGCAGCCCTGTGCCTCTCGAATGTTAGCCTTGGATGGGGCTTTCACAGTTAGAAGAGCTGAAACCAGGGGTGCA
GCTGTCAGGTAGGGTGGGGCCGGTGGGAGAGGCCCGGGTCAGAGCCCTGGGGGTGAGCCTGAAGGCCACAGAGAAAGAACCTTGCCCAAA
CTCAGGCAGCTGGGGCTGAGGCCCAAAGGCAGAACAGCCAGAGGGGGCAGGAGGGGACCAAAAAGGAAAATGAGGACGTGCAGCAGCATT
GGAAGGCTGGGGCCGGGCAGGCCAGGCCAAGCCAAGCAGGGGGCCACAGGGTGGGCTGTGGAGCTCTCAGGAAGGGCCCTGAGGAAGGCA
CACTTGCTCCTGTTGGTCCCTGTCCTTGCTGCCCAGGCAGCGTGGAGGGGAAGGGTAGGGCAGCCAGAGAAAGGAGCAGAGAAGGCACAC
AAACGAGGAATGAGGGGCTTCACGAGAGGCCACAGGGCCTGGCTGGCCACGCTGTCCCGGCCTGCTCACCATCTCAGTGAGGGGCAGGAG
CTGGGGCTCGCTTAGGCTGGGTCCACGCTTCCCTGGTGCCAGCACCCCTCAAGCCTGTCTCACCAGTGGCCTGCCCTCTCGCTCCCCCAC
CCAGCCCACCCATTGAAGTCTCCTTGGGCCACCAAAGGTGGTGGCCATGGTACCGGGGACTTGGGAGAGTGAGACCCAGTGGAGGGAGCA
AGAGGAGAGGGATGTCGGGGGGGTGGGGCACGGGGTAGGGGAAATGGGGTGAACGGTGCTGGCAGTTCGGCTAGATTTCTGTCTTGTTTG
TTTTTTTGTTTTGTTTAATGTATATTTTTATTATAATTATTATATATGAATTCCATTCAAATCGTTCCTTTTTGTTAACAAGGGGCATGG
GGAGGGGTGGGGGTGGGGGGGCAGAGGCGTCTGACCCCAGGAACCTGCAGGGCGGGGCTGGGTCGGTGCCCTCTAAGGACAATTTTGACC
TTGTTCAACCTTTCCACAAAGAATAAATTGTGTTTCACATTCAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGG
AGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAA
AAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAA
TAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCT
GCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCC
GGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCC
CGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGG
CTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAG
ATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTG
TTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAA
CACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAA
GTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTT
GAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCAC
CCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTG
GATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGT
GCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGA
GGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCT
GGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTT
ATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAAT
CGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTAT
GCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAA
GTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTC
ATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCT
GGAGAATCTGAAGAATGAAGACATTGAGAAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCTCGTGATGCATCTAC
AGTTATTTATTGTTACATCCTTTTCCAGACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCT
GTGTAATCGTGGGGGTACCATCTCAACTGCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTT
AAGAAACGTTTATTGTAACAGTAATTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACT
ATTTTAACAGCTTAAACAGGAGCTCTCAAGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGC
CATTTGATTGTAGAGGGTCCACCACAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTA
GGGCTGATGGAGACCCATGTGAGCCTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAATCAGGACCAGCATG
TGCAGAGCTGGCCACCAGCACAGGCTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTA
AATTACAGGAAATAAGGGAGAAATCTTGCAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAAAGTATTAACTAGCT
AACAGTGATGGGCCAAGACGCTCCGAGAACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACTTTCTTACTGCTCAC
ATCTTACAGGTGAGTACTCATAATTGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGT
GGCCCAGCTCATCCCCTACTCTGTTATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGC
TCATGATGAACTTTATCACTAGTTATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAA
GTGATGAATTTGGGTTACCGTCTCATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATT
GGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATATGGAACTATGCAGTT
GAGTATTGAAAGCTTTAAACTGAGTTTATTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTT
ATCCGAGGGGTCTGTGGTTGTATCAGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGA
TTGAGAAACTGGTCAATGAACAGGAAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTGTTTCATTTATTTGTAATAAACCTCTTCCAC

>In-frame_ENST00000311852_ENST00000280326_TCGA-IW-A3M6-01A_MMP14_chr14_23316970_-_CCT5_chr5_10250033_length(amino acids)=589AA_start in transcript=240_stop in transcript=2009
MTRWSRTMSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADAD
TMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEK
QADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQW
MDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGY
PMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELR
AVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEG

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Fusion Gene PPI Analysis for MMP14-CCT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MMP14-CCT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MMP14-CCT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMMP14C0001418Adenocarcinoma1CTD_human
HgeneMMP14C0006142Malignant neoplasm of breast1CTD_human
HgeneMMP14C0007621Neoplastic Cell Transformation1CTD_human
HgeneMMP14C0014859Esophageal Neoplasms1CTD_human
HgeneMMP14C0024117Chronic Obstructive Airway Disease1CTD_human
HgeneMMP14C0027626Neoplasm Invasiveness1CTD_human
HgeneMMP14C0162871Aortic Aneurysm, Abdominal1CTD_human
HgeneMMP14C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneMMP14C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneMMP14C0205643Carcinoma, Cribriform1CTD_human
HgeneMMP14C0205644Carcinoma, Granular Cell1CTD_human
HgeneMMP14C0205645Adenocarcinoma, Tubular1CTD_human
HgeneMMP14C0432289Winchester syndrome (disorder)1CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneMMP14C0546837Malignant neoplasm of esophagus1CTD_human
HgeneMMP14C0678222Breast Carcinoma1CTD_human
HgeneMMP14C1257931Mammary Neoplasms, Human1CTD_human
HgeneMMP14C1458155Mammary Neoplasms1CTD_human
HgeneMMP14C1527303Chronic Airflow Obstruction1CTD_human
HgeneMMP14C2931456Prostate cancer, familial1CTD_human
HgeneMMP14C4704874Mammary Carcinoma, Human1CTD_human
HgeneMMP14C4722327PROSTATE CANCER, HEREDITARY, 11CTD_human
TgeneCCT5C1850395Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCCT5C0006142Malignant neoplasm of breast1CTD_human
TgeneCCT5C0019193Hepatitis, Toxic1CTD_human
TgeneCCT5C0019693HIV Infections1CTD_human
TgeneCCT5C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneCCT5C0678222Breast Carcinoma1CTD_human
TgeneCCT5C0860207Drug-Induced Liver Disease1CTD_human
TgeneCCT5C1257931Mammary Neoplasms, Human1CTD_human
TgeneCCT5C1262760Hepatitis, Drug-Induced1CTD_human
TgeneCCT5C1458155Mammary Neoplasms1CTD_human
TgeneCCT5C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneCCT5C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCCT5C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneCCT5C4505456HIV Coinfection1CTD_human
TgeneCCT5C4704874Mammary Carcinoma, Human1CTD_human