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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AP4M1-AGAP3 (FusionGDB2 ID:5412)

Fusion Gene Summary for AP4M1-AGAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: AP4M1-AGAP3
Fusion gene ID: 5412
HgeneTgene
Gene symbol

AP4M1

AGAP3

Gene ID

9179

116988

Gene nameadaptor related protein complex 4 subunit mu 1ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
SynonymsCPSQ3|MU-4|MU-ARP2|SPG50AGAP-3|CENTG3|CRAG|MRIP-1|cnt-g3
Cytomap

7q22.1

7q36.1

Type of geneprotein-codingprotein-coding
DescriptionAP-4 complex subunit mu-1AP-4 adaptor complex mu subunitadapter-related protein complex 4 mu-1 subunitadapter-related protein complex 4 subunit mu-1adaptor related protein complex 4 mu 1 subunitadaptor-related protein complex AP-4 mu4 subunitmu subuarf-GAP with GTPase, ANK repeat and PH domain-containing protein 3CRAM-associated GTPaseCRMP (collapsin response mediator protein) associatedMR1-interacting proteincentaurin-gamma-3
Modification date2020031320200313
UniProtAcc

O00189

Q96P47

Ensembl transtripts involved in fusion geneENST00000429084, ENST00000359593, 
ENST00000478501, ENST00000421755, 
ENST00000422582, 		ENST00000463381, 
ENST00000473312, ENST00000479901, 
ENST00000397238, ENST00000476375, 
ENST00000335367, 
Fusion gene scores* DoF score1 X 2 X 2=49 X 10 X 6=540
# samples 210
** MAII scorelog2(2/4*10)=2.32192809488736log2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AP4M1 [Title/Abstract] AND AGAP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAP4M1(99704137)-AGAP3(150820875), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAP4M1

GO:0006605

protein targeting

20230749

HgeneAP4M1

GO:0006622

protein targeting to lysosome

11139587

HgeneAP4M1

GO:0090160

Golgi to lysosome transport

11139587


check buttonFusion gene breakpoints across AP4M1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across AGAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAK131236AP4M1chr7

99704137

+AGAP3chr7

150820875

+


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Fusion Gene ORF analysis for AP4M1-AGAP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000429084ENST00000463381AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000429084ENST00000473312AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000429084ENST00000479901AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000429084ENST00000397238AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000429084ENST00000476375AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000429084ENST00000335367AP4M1chr7

99704137

+AGAP3chr7

150820875

+
In-frameENST00000359593ENST00000463381AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000359593ENST00000473312AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000359593ENST00000479901AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000359593ENST00000397238AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000359593ENST00000476375AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000359593ENST00000335367AP4M1chr7

99704137

+AGAP3chr7

150820875

+
intron-3CDSENST00000478501ENST00000463381AP4M1chr7

99704137

+AGAP3chr7

150820875

+
intron-intronENST00000478501ENST00000473312AP4M1chr7

99704137

+AGAP3chr7

150820875

+
intron-intronENST00000478501ENST00000479901AP4M1chr7

99704137

+AGAP3chr7

150820875

+
intron-intronENST00000478501ENST00000397238AP4M1chr7

99704137

+AGAP3chr7

150820875

+
intron-intronENST00000478501ENST00000476375AP4M1chr7

99704137

+AGAP3chr7

150820875

+
intron-intronENST00000478501ENST00000335367AP4M1chr7

99704137

+AGAP3chr7

150820875

+
In-frameENST00000421755ENST00000463381AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000421755ENST00000473312AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000421755ENST00000479901AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000421755ENST00000397238AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000421755ENST00000476375AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000421755ENST00000335367AP4M1chr7

99704137

+AGAP3chr7

150820875

+
In-frameENST00000422582ENST00000463381AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000422582ENST00000473312AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000422582ENST00000479901AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000422582ENST00000397238AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000422582ENST00000476375AP4M1chr7

99704137

+AGAP3chr7

150820875

+
5CDS-intronENST00000422582ENST00000335367AP4M1chr7

99704137

+AGAP3chr7

150820875

+
intron-intronENST00000359593ENST00000335367AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000359593ENST00000397238AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000359593ENST00000463381AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000359593ENST00000473312AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000359593ENST00000476375AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000359593ENST00000479901AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000421755ENST00000335367AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000421755ENST00000397238AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000421755ENST00000463381AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000421755ENST00000473312AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000421755ENST00000476375AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000421755ENST00000479901AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000422582ENST00000335367AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000422582ENST00000397238AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000422582ENST00000463381AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000422582ENST00000473312AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000422582ENST00000476375AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000422582ENST00000479901AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000429084ENST00000335367AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000429084ENST00000397238AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000429084ENST00000463381AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000429084ENST00000473312AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000429084ENST00000476375AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000429084ENST00000479901AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000478501ENST00000335367AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000478501ENST00000397238AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000478501ENST00000463381AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000478501ENST00000473312AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000478501ENST00000476375AP4M1chr7

99542073

+AGAP3chr7

150451807

+
intron-intronENST00000478501ENST00000479901AP4M1chr7

99542073

+AGAP3chr7

150451807

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000429084AP4M1chr799704137+ENST00000463381AGAP3chr7150820875+31061316892614841
ENST00000359593AP4M1chr799704137+ENST00000463381AGAP3chr7150820875+30851295892593834
ENST00000421755AP4M1chr799704137+ENST00000463381AGAP3chr7150820875+29781188512486811
ENST00000422582AP4M1chr799704137+ENST00000463381AGAP3chr7150820875+311313233032621772

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000429084ENST00000463381AP4M1chr799704137+AGAP3chr7150820875+0.0120368010.9879632
ENST00000359593ENST00000463381AP4M1chr799704137+AGAP3chr7150820875+0.0155797630.98442024
ENST00000421755ENST00000463381AP4M1chr799704137+AGAP3chr7150820875+0.0186830810.9813169
ENST00000422582ENST00000463381AP4M1chr799704137+AGAP3chr7150820875+0.0224234010.97757655

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Fusion Genomic Features for AP4M1-AGAP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AP4M1chr799704137+AGAP3chr7150820880+0.000263330.9997366
AP4M1chr799704137+AGAP3chr7150820880+0.000263330.9997366

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AP4M1-AGAP3


check button Go to

FGviewer for the breakpoints of chr7:99704137-chr7:150820875

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AP4M1

O00189

AGAP3

Q96P47

FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity). {ECO:0000250|UniProtKB:E2RED8, ECO:0000250|UniProtKB:Q2PWT8, ECO:0000250|UniProtKB:Q9JKC7, ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000269|PubMed:11139587, ECO:0000269|PubMed:11802162, ECO:0000269|PubMed:20230749, ECO:0000269|PubMed:26544806}.FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAGAP3chr7:99704137chr7:150820875ENST00000397238718626_746376.0912.0DomainArf-GAP
TgeneAGAP3chr7:99704137chr7:150820875ENST00000397238718748_777376.0912.0RepeatNote=ANK 1
TgeneAGAP3chr7:99704137chr7:150820875ENST00000397238718785_814376.0912.0RepeatNote=ANK 2
TgeneAGAP3chr7:99704137chr7:150820875ENST00000397238718818_847376.0912.0RepeatNote=ANK 3
TgeneAGAP3chr7:99704137chr7:150820875ENST00000397238718641_664376.0912.0Zinc fingerC4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAP4M1chr7:99704137chr7:150820875ENST00000359593+1415184_452379.0454.0DomainMHD
HgeneAP4M1chr7:99704137chr7:150820875ENST00000421755+1416184_452379.0460.6666666666667DomainMHD
TgeneAGAP3chr7:99704137chr7:150820875ENST00000397238718367_605376.0912.0DomainPH
TgeneAGAP3chr7:99704137chr7:150820875ENST00000397238718142_146376.0912.0Nucleotide bindingGTP
TgeneAGAP3chr7:99704137chr7:150820875ENST00000397238718198_201376.0912.0Nucleotide bindingGTP
TgeneAGAP3chr7:99704137chr7:150820875ENST0000039723871898_105376.0912.0Nucleotide bindingGTP
TgeneAGAP3chr7:99704137chr7:150820875ENST0000039723871884_375376.0912.0RegionNote=Small GTPase-like


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Fusion Gene Sequence for AP4M1-AGAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000429084_ENST00000463381_AK131236_AP4M1_chr7_99704137_+_AGAP3_chr7_150820875_length(transcript)=3106nt_BP=1316nt
GGGGTAGTGCAGGCGCCGGGTTTCCCGCGGTCCGAGCTGGCGCGGGCGGAGGAGAATCGCTCTTAAAGGGCCAGCGCACACGCGTTCTTT
TGTTCCGGGGCCGCAGGGCGGGGCAGGCCCGACTTTCGCCGTCTTCTTGTCTACTCTCCAGAACGGCCATGATTTCCCAATTCTTCATTC
TGTCCTCCAAGGGGGACCCGCTCATCTACAAAGACTTCCGCGGGGACAGTGGCGGCCGGGATGTGGCCGAGCTCTTCTACCGGAAGCTGA
CGGGACTGCCAGGAGACGAGTCCCCGGTTGTCATGGTAACCAGTGGCGGGAGGCGGCATCACCATGGCCGTCATTTCATTCACATCAGAC
ACAGCGGCCTCTATTTGGTGGTCACAACTTCAGAAAACGTTTCTCCCTTCAGCCTCCTAGAACTGCTCTCCAGGTTGGCCACCCTTCTGG
GCGATTACTGTGGCTCCCTGGGCGAGGGGACCATCTCCCGCAATGTGGCTCTGGTATACGAACTCCTGGATGAAGTGCTGGACTATGGCT
ATGTACAGACCACATCCACGGAGATGCTGAGGAATTTCATCCAGACGGAAGCTGTGGTCAGCAAGCCCTTCAGCCTCTTTGACCTCAGCA
GCGTTGGCTTGTTTGGGGCTGAGACACAACAGAGCAAAGTGGCCCCCAGCAGTGCAGCCAGCCGCCCCGTCCTGTCCAGTCGCTCTGACC
AGAGCCAAAAGAATGAAGTTTTTTTGGATGTGGTCGAGAGATTGTCTGTACTGATAGCATCTAATGGATCCCTGCTGAAGGTGGATGTGC
AGGGAGAGATTCGGCTCAAGAGCTTCCTTCCTAGCGGCTCTGAGATGCGCATTGGCTTGACGGAAGAGTTTTGTGTGGGGAAGTCAGAGC
TGAGAGGTTATGGGCCAGGAATCCGGGTCGATGAAGTCTCGTTTCACAGCTCTGTGAATCTGGACGAATTTGAGTCTCATCGAATCCTCC
GCTTGCAACCACCTCAGGGCGAGCTGACTGTGATGCGGTACCAACTCTCCGATGACCTCCCCTCACCGCTCCCCTTCCGGCTCTTCCCCT
CTGTGCAGTGGGACCGAGGCTCAGGCCGGCTCCAGGTTTATCTAAAGTTGCGATGTGACCTGCTCTCAAAGAGCCAAGCCCTCAATGTCA
GGCTGCACCTCCCCCTGCCTCGAGGGGTGGTCAGCCTGTCTCAGGAGCTGAGCAGCCCAGAGCAGAAGGCTGAGCTGGCAGAGGGAGCCC
TTCGCTGGGACCTGCCTCGGGTGCAAGGAGGCTCTCAACTCTCAGGCCTTTTCCAGTCTCGGAAGGGTGCTGACCTGGACCGGGAGAAGA
AGGCTGCCGAGTGCAAGGTGGACAGCATCGGGAGCGGCCGCGCCATCCCCATCAAGCAGGGGATCCTGCTAAAGCGGAGCGGCAAGTCCC
TGAACAAGGAGTGGAAGAAGAAGTATGTGACGCTCTGTGACAACGGGCTGCTCACCTATCACCCCAGCCTGCATGATTACATGCAGAACA
TCCACGGCAAGGAGATTGACCTGCTGCGGACAACGGTGAAAGTGCCAGGGAAGCGCCTGCCCCGAGCCACACCTGCCACAGCCCCGGGCA
CCAGCCCCCGTGCCAACGGGCTGTCCGTGGAGCGGAGTAACACACAGCTGGGTGGGGGCACAGAGGCAGAGGAGTCGTTTGAATTTGTGG
TGGTGTCCCTCACTGGGCAGACGTGGCACTTCGAGGCTTCAACGGCGGAGGAGCGGGAGCTGTGGGTTCAGAGTGTGCAGGCCCAGATCC
TTGCCAGCCTGCAAGGCTGCCGCAGTGCCAAGGACAAGACTCGACTGGGGAACCAGAACGCAGCTCTGGCTGTGCAGGCCGTCCGCACCG
TCCGCGGCAACAGCTTTTGTATCGACTGCGATGCACCCAATCCAGACTGGGCCAGCCTGAACCTGGGTGCCCTGATGTGCATTGAGTGCT
CAGGCATCCACCGACACCTGGGGGCTCACCTGTCCCGGGTGCGCTCCCTTGACCTCGATGACTGGCCGCCTGAGCTGCTGGCTGTCATGA
CTGCCATGGGCAATGCCCTCGCCAACAGCGTCTGGGAGGGGGCCTTGGGTGGCTACTCCAAGCCAGGGCCTGATGCCTGCAGAGAGGAGA
AGGAACGCTGGATACGGGCCAAGTATGAACAGAAGCTCTTCCTGGCCCCACTGCCAAGCTCAGATGTGCCACTGGGGCAGCAGCTGCTCC
GGGCCGTGGTGGAAGATGACCTGCGGCTGTTGGTGATGCTCCTGGCACATGGCTCCAAAGAGGAGGTGAATGAGACCTATGGGGACGGGG
ACGGGCGGACGGCTCTACATCTCTCCAGTGCCATGGCCAACGTTGTCTTCACGCAGCTGCTCATCTGGTACGGGGTGGACGTGAGGAGCC
GGGACGCCCGGGGCCTGACTCCACTGGCATATGCTCGCCGGGCCGGCAGCCAGGAGTGTGCAGACATCTTGATCCAGCATGGCTGCCCTG
GGGAGGGCTGTGGCTTAGCGCCTACCCCCAACAGAGAGCCTGCCAATGGCACCAACCCCTCTGCTGAGCTGCACCGTAGTCCTAGCCTCC
TATAAGGCCCAGGAAGAGGGCAGAGGGGCCAGAAGGACTCCATGGCCCAAAGACCCTCCTCCCTGCAGGCACTGTGGGAACAGACACAGA
GATGGAGAAGCAGGGACATGCTGAGAGGACGAAGCCAAGGAAATTAGGGAGGAGAGTCAAAGGGATCAAGGAGAGTTGGGGATTTGAGCT
GCAGCAGAGAGGGATGAGGGATTTAGCCCTCTGCCCTAAGGTGCCATTGAAAAGGGACAGGACCCTTCGGAGGTGCCTGTGAGGAGAGGG
GAGCAGGACCTCTCCCTCCTCCAGATCCCTGCCTCCTAGTGCCAGCCCCTCACACGCCTTCATCCTGAAACAGGAAGAGGACGGCACCAA
GTTGGGGGTGCTGGATGAAAGAGACGAGGGGTGATCTGTGAGTCCCATGTAAACTTTGTACATTGGAATATTTATGTTTGTGTACATATT

>In-frame_ENST00000429084_ENST00000463381_AK131236_AP4M1_chr7_99704137_+_AGAP3_chr7_150820875_length(amino acids)=841AA_start in transcript=89_stop in transcript=2614
MFRGRRAGQARLSPSSCLLSRTAMISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMVTSGGRRHHHGRHFIHIR
HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLS
SVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSE
LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNV
RLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKS
LNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTEAEESFEFV
VVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIEC
SGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLL
RAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCP

--------------------------------------------------------------
>In-frame_ENST00000359593_ENST00000463381_AK131236_AP4M1_chr7_99704137_+_AGAP3_chr7_150820875_length(transcript)=3085nt_BP=1295nt
GGGGTAGTGCAGGCGCCGGGTTTCCCGCGGTCCGAGCTGGCGCGGGCGGAGGAGAATCGCTCTTAAAGGGCCAGCGCACACGCGTTCTTT
TGTTCCGGGGCCGCAGGGCGGGGCAGGCCCGACTTTCGCCGTCTTCTTGTCTACTCTCCAGAACGGCCATGATTTCCCAATTCTTCATTC
TGTCCTCCAAGGGGGACCCGCTCATCTACAAAGACTTCCGCGGGGACAGTGGCGGCCGGGATGTGGCCGAGCTCTTCTACCGGAAGCTGA
CGGGACTGCCAGGAGACGAGTCCCCGGTTGTCATGCATCACCATGGCCGTCATTTCATTCACATCAGACACAGCGGCCTCTATTTGGTGG
TCACAACTTCAGAAAACGTTTCTCCCTTCAGCCTCCTAGAACTGCTCTCCAGGTTGGCCACCCTTCTGGGCGATTACTGTGGCTCCCTGG
GCGAGGGGACCATCTCCCGCAATGTGGCTCTGGTATACGAACTCCTGGATGAAGTGCTGGACTATGGCTATGTACAGACCACATCCACGG
AGATGCTGAGGAATTTCATCCAGACGGAAGCTGTGGTCAGCAAGCCCTTCAGCCTCTTTGACCTCAGCAGCGTTGGCTTGTTTGGGGCTG
AGACACAACAGAGCAAAGTGGCCCCCAGCAGTGCAGCCAGCCGCCCCGTCCTGTCCAGTCGCTCTGACCAGAGCCAAAAGAATGAAGTTT
TTTTGGATGTGGTCGAGAGATTGTCTGTACTGATAGCATCTAATGGATCCCTGCTGAAGGTGGATGTGCAGGGAGAGATTCGGCTCAAGA
GCTTCCTTCCTAGCGGCTCTGAGATGCGCATTGGCTTGACGGAAGAGTTTTGTGTGGGGAAGTCAGAGCTGAGAGGTTATGGGCCAGGAA
TCCGGGTCGATGAAGTCTCGTTTCACAGCTCTGTGAATCTGGACGAATTTGAGTCTCATCGAATCCTCCGCTTGCAACCACCTCAGGGCG
AGCTGACTGTGATGCGGTACCAACTCTCCGATGACCTCCCCTCACCGCTCCCCTTCCGGCTCTTCCCCTCTGTGCAGTGGGACCGAGGCT
CAGGCCGGCTCCAGGTTTATCTAAAGTTGCGATGTGACCTGCTCTCAAAGAGCCAAGCCCTCAATGTCAGGCTGCACCTCCCCCTGCCTC
GAGGGGTGGTCAGCCTGTCTCAGGAGCTGAGCAGCCCAGAGCAGAAGGCTGAGCTGGCAGAGGGAGCCCTTCGCTGGGACCTGCCTCGGG
TGCAAGGAGGCTCTCAACTCTCAGGCCTTTTCCAGTCTCGGAAGGGTGCTGACCTGGACCGGGAGAAGAAGGCTGCCGAGTGCAAGGTGG
ACAGCATCGGGAGCGGCCGCGCCATCCCCATCAAGCAGGGGATCCTGCTAAAGCGGAGCGGCAAGTCCCTGAACAAGGAGTGGAAGAAGA
AGTATGTGACGCTCTGTGACAACGGGCTGCTCACCTATCACCCCAGCCTGCATGATTACATGCAGAACATCCACGGCAAGGAGATTGACC
TGCTGCGGACAACGGTGAAAGTGCCAGGGAAGCGCCTGCCCCGAGCCACACCTGCCACAGCCCCGGGCACCAGCCCCCGTGCCAACGGGC
TGTCCGTGGAGCGGAGTAACACACAGCTGGGTGGGGGCACAGAGGCAGAGGAGTCGTTTGAATTTGTGGTGGTGTCCCTCACTGGGCAGA
CGTGGCACTTCGAGGCTTCAACGGCGGAGGAGCGGGAGCTGTGGGTTCAGAGTGTGCAGGCCCAGATCCTTGCCAGCCTGCAAGGCTGCC
GCAGTGCCAAGGACAAGACTCGACTGGGGAACCAGAACGCAGCTCTGGCTGTGCAGGCCGTCCGCACCGTCCGCGGCAACAGCTTTTGTA
TCGACTGCGATGCACCCAATCCAGACTGGGCCAGCCTGAACCTGGGTGCCCTGATGTGCATTGAGTGCTCAGGCATCCACCGACACCTGG
GGGCTCACCTGTCCCGGGTGCGCTCCCTTGACCTCGATGACTGGCCGCCTGAGCTGCTGGCTGTCATGACTGCCATGGGCAATGCCCTCG
CCAACAGCGTCTGGGAGGGGGCCTTGGGTGGCTACTCCAAGCCAGGGCCTGATGCCTGCAGAGAGGAGAAGGAACGCTGGATACGGGCCA
AGTATGAACAGAAGCTCTTCCTGGCCCCACTGCCAAGCTCAGATGTGCCACTGGGGCAGCAGCTGCTCCGGGCCGTGGTGGAAGATGACC
TGCGGCTGTTGGTGATGCTCCTGGCACATGGCTCCAAAGAGGAGGTGAATGAGACCTATGGGGACGGGGACGGGCGGACGGCTCTACATC
TCTCCAGTGCCATGGCCAACGTTGTCTTCACGCAGCTGCTCATCTGGTACGGGGTGGACGTGAGGAGCCGGGACGCCCGGGGCCTGACTC
CACTGGCATATGCTCGCCGGGCCGGCAGCCAGGAGTGTGCAGACATCTTGATCCAGCATGGCTGCCCTGGGGAGGGCTGTGGCTTAGCGC
CTACCCCCAACAGAGAGCCTGCCAATGGCACCAACCCCTCTGCTGAGCTGCACCGTAGTCCTAGCCTCCTATAAGGCCCAGGAAGAGGGC
AGAGGGGCCAGAAGGACTCCATGGCCCAAAGACCCTCCTCCCTGCAGGCACTGTGGGAACAGACACAGAGATGGAGAAGCAGGGACATGC
TGAGAGGACGAAGCCAAGGAAATTAGGGAGGAGAGTCAAAGGGATCAAGGAGAGTTGGGGATTTGAGCTGCAGCAGAGAGGGATGAGGGA
TTTAGCCCTCTGCCCTAAGGTGCCATTGAAAAGGGACAGGACCCTTCGGAGGTGCCTGTGAGGAGAGGGGAGCAGGACCTCTCCCTCCTC
CAGATCCCTGCCTCCTAGTGCCAGCCCCTCACACGCCTTCATCCTGAAACAGGAAGAGGACGGCACCAAGTTGGGGGTGCTGGATGAAAG
AGACGAGGGGTGATCTGTGAGTCCCATGTAAACTTTGTACATTGGAATATTTATGTTTGTGTACATATTTGATGTGTGTGTGTATGATGA

>In-frame_ENST00000359593_ENST00000463381_AK131236_AP4M1_chr7_99704137_+_AGAP3_chr7_150820875_length(amino acids)=834AA_start in transcript=89_stop in transcript=2593
MFRGRRAGQARLSPSSCLLSRTAMISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIRHSGLYLV
VTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGA
ETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPG
IRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLP
RGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKK
KYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTEAEESFEFVVVSLTGQ
TWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHL
GAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDD
LRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLA

--------------------------------------------------------------
>In-frame_ENST00000421755_ENST00000463381_AK131236_AP4M1_chr7_99704137_+_AGAP3_chr7_150820875_length(transcript)=2978nt_BP=1188nt
GCGGGGCAGGCCCGACTTTCGCCGTCTTCTTGTCTACTCTCCAGAACGGCCATGATTTCCCAATTCTTCATTCTGTCCTCCAAGGGGGAC
CCGCTCATCTACAAAGACTTCCGCGGGGACAGTGGCGGCCGGGATGTGGCCGAGCTCTTCTACCGGAAGCTGACGGGACTGCCAGGAGAC
GAGTCCCCGGTTGTCATGCATCACCATGGCCGTCATTTCATTCACATCAGACACAGCGGCCTCTATTTGGTGGTCACAACTTCAGAAAAC
GTTTCTCCCTTCAGCCTCCTAGAACTGCTCTCCAGGTTGGCCACCCTTCTGGGCGATTACTGTGGCTCCCTGGGCGAGGGGACCATCTCC
CGCAATGTGGCTCTGGTATACGAACTCCTGGATGAAGTGCTGGACTATGGCTATGTACAGACCACATCCACGGAGATGCTGAGGAATTTC
ATCCAGACGGAAGCTGTGGTCAGCAAGCCCTTCAGCCTCTTTGACCTCAGCAGCGTTGGCTTGTTTGGGGCTGAGACACAACAGAGCAAA
GTGGCCCCCAGCAGTGCAGCCAGCCGCCCCGTCCTGTCCAGTCGCTCTGACCAGAGCCAAAAGAATGAAGTTTTTTTGGATGTGGTCGAG
AGATTGTCTGTACTGATAGCATCTAATGGATCCCTGCTGAAGGTGGATGTGCAGGGAGAGATTCGGCTCAAGAGCTTCCTTCCTAGCGGC
TCTGAGATGCGCATTGGCTTGACGGAAGAGTTTTGTGTGGGGAAGTCAGAGCTGAGAGGTTATGGGCCAGGAATCCGGGTCGATGAAGTC
TCGTTTCACAGCTCTGTGAATCTGGACGAATTTGAGTCTCATCGAATCCTCCGCTTGCAACCACCTCAGGGCGAGCTGACTGTGATGCGG
TACCAACTCTCCGATGACCTCCCCTCACCGCTCCCCTTCCGGCTCTTCCCCTCTGTGCAGTGGGACCGAGGCTCAGGCCGGCTCCAGGTT
TATCTAAAGTTGCGATGTGACCTGCTCTCAAAGAGCCAAGCCCTCAATGTCAGGCTGCACCTCCCCCTGCCTCGAGGGGTGGTCAGCCTG
TCTCAGGAGCTGAGCAGCCCAGAGCAGAAGGCTGAGCTGGCAGAGGGAGCCCTTCGCTGGGACCTGCCTCGGGTGCAAGGAGGCTCTCAA
CTCTCAGGCCTTTTCCAGTCTCGGAAGGGTGCTGACCTGGACCGGGAGAAGAAGGCTGCCGAGTGCAAGGTGGACAGCATCGGGAGCGGC
CGCGCCATCCCCATCAAGCAGGGGATCCTGCTAAAGCGGAGCGGCAAGTCCCTGAACAAGGAGTGGAAGAAGAAGTATGTGACGCTCTGT
GACAACGGGCTGCTCACCTATCACCCCAGCCTGCATGATTACATGCAGAACATCCACGGCAAGGAGATTGACCTGCTGCGGACAACGGTG
AAAGTGCCAGGGAAGCGCCTGCCCCGAGCCACACCTGCCACAGCCCCGGGCACCAGCCCCCGTGCCAACGGGCTGTCCGTGGAGCGGAGT
AACACACAGCTGGGTGGGGGCACAGAGGCAGAGGAGTCGTTTGAATTTGTGGTGGTGTCCCTCACTGGGCAGACGTGGCACTTCGAGGCT
TCAACGGCGGAGGAGCGGGAGCTGTGGGTTCAGAGTGTGCAGGCCCAGATCCTTGCCAGCCTGCAAGGCTGCCGCAGTGCCAAGGACAAG
ACTCGACTGGGGAACCAGAACGCAGCTCTGGCTGTGCAGGCCGTCCGCACCGTCCGCGGCAACAGCTTTTGTATCGACTGCGATGCACCC
AATCCAGACTGGGCCAGCCTGAACCTGGGTGCCCTGATGTGCATTGAGTGCTCAGGCATCCACCGACACCTGGGGGCTCACCTGTCCCGG
GTGCGCTCCCTTGACCTCGATGACTGGCCGCCTGAGCTGCTGGCTGTCATGACTGCCATGGGCAATGCCCTCGCCAACAGCGTCTGGGAG
GGGGCCTTGGGTGGCTACTCCAAGCCAGGGCCTGATGCCTGCAGAGAGGAGAAGGAACGCTGGATACGGGCCAAGTATGAACAGAAGCTC
TTCCTGGCCCCACTGCCAAGCTCAGATGTGCCACTGGGGCAGCAGCTGCTCCGGGCCGTGGTGGAAGATGACCTGCGGCTGTTGGTGATG
CTCCTGGCACATGGCTCCAAAGAGGAGGTGAATGAGACCTATGGGGACGGGGACGGGCGGACGGCTCTACATCTCTCCAGTGCCATGGCC
AACGTTGTCTTCACGCAGCTGCTCATCTGGTACGGGGTGGACGTGAGGAGCCGGGACGCCCGGGGCCTGACTCCACTGGCATATGCTCGC
CGGGCCGGCAGCCAGGAGTGTGCAGACATCTTGATCCAGCATGGCTGCCCTGGGGAGGGCTGTGGCTTAGCGCCTACCCCCAACAGAGAG
CCTGCCAATGGCACCAACCCCTCTGCTGAGCTGCACCGTAGTCCTAGCCTCCTATAAGGCCCAGGAAGAGGGCAGAGGGGCCAGAAGGAC
TCCATGGCCCAAAGACCCTCCTCCCTGCAGGCACTGTGGGAACAGACACAGAGATGGAGAAGCAGGGACATGCTGAGAGGACGAAGCCAA
GGAAATTAGGGAGGAGAGTCAAAGGGATCAAGGAGAGTTGGGGATTTGAGCTGCAGCAGAGAGGGATGAGGGATTTAGCCCTCTGCCCTA
AGGTGCCATTGAAAAGGGACAGGACCCTTCGGAGGTGCCTGTGAGGAGAGGGGAGCAGGACCTCTCCCTCCTCCAGATCCCTGCCTCCTA
GTGCCAGCCCCTCACACGCCTTCATCCTGAAACAGGAAGAGGACGGCACCAAGTTGGGGGTGCTGGATGAAAGAGACGAGGGGTGATCTG
TGAGTCCCATGTAAACTTTGTACATTGGAATATTTATGTTTGTGTACATATTTGATGTGTGTGTGTATGATGAGCCAATAAACCAGACTG

>In-frame_ENST00000421755_ENST00000463381_AK131236_AP4M1_chr7_99704137_+_AGAP3_chr7_150820875_length(amino acids)=811AA_start in transcript=51_stop in transcript=2486
MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLL
GDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD
QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRIL
RLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGA
LRWDLPRVQGGSQLSGLFQSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQN
IHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQI
LASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVM
TAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDG
DGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSL

--------------------------------------------------------------
>In-frame_ENST00000422582_ENST00000463381_AK131236_AP4M1_chr7_99704137_+_AGAP3_chr7_150820875_length(transcript)=3113nt_BP=1323nt
ACTTGGGGGGTGCATTCCGCCAAATAAAGCTAACGTGAGGCCCGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGG
CGGGCGGATCACCTGAGGTCAGGAGTTCGAAATCAGCCTGGCCAACATGGTGAAACTCCGCCTCTACTAAAAATACAAAAAAAAAAAAAA
CATAGCTGGGCGTGGTGGCGGGCGCCTGTAATCCCATCTACTCGGGAAGCTGAGGCTTGAGAATCGCTTGAATCCAAGAGGCAGAGGTTG
CAGTGAGCCGAGATCCGGACACCGCACTCCAGCCTGGGAGACAGAGCGAGACTCCCTCTCGGGCATCACCATGGCCGTCATTTCATTCAC
ATCAGACACAGCGGCCTCTATTTGGTGGTCACAACTTCAGAAAACGTTTCTCCCTTCAGCCTCCTAGAACTGCTCTCCAGGTTGGCCACC
CTTCTGGGCGATTACTGTGGCTCCCTGGGCGAGGGGACCATCTCCCGCAATGTGGCTCTGGTATACGAACTCCTGGATGAAGTGCTGGAC
TATGGCTATGTACAGACCACATCCACGGAGATGCTGAGGAATTTCATCCAGACGGAAGCTGTGGTCAGCAAGCCCTTCAGCCTCTTTGAC
CTCAGCAGCGTTGGCTTGTTTGGGGCTGAGACACAACAGAGCAAAGTGGCCCCCAGCAGTGCAGCCAGCCGCCCCGTCCTGTCCAGTCGC
TCTGACCAGAGCCAAAAGAATGAAGTTTTTTTGGATGTGGTCGAGAGATTGTCTGTACTGATAGCATCTAATGGATCCCTGCTGAAGGTG
GATGTGCAGGGAGAGATTCGGCTCAAGAGCTTCCTTCCTAGCGGCTCTGAGATGCGCATTGGCTTGACGGAAGAGTTTTGTGTGGGGAAG
TCAGAGCTGAGAGGTTATGGGCCAGGAATCCGGGTCGATGAAGTCTCGTTTCACAGCTCTGTGAATCTGGACGAATTTGAGTCTCATCGA
ATCCTCCGCTTGCAACCACCTCAGGGCGAGCTGACTGTGATGCGGTACCAACTCTCCGATGACCTCCCCTCACCGCTCCCCTTCCGGCTC
TTCCCCTCTGTGCAGTGGGACCGAGGCTCAGGCCGGCTCCAGGTTTATCTAAAGTTGCGATGTGACCTGCTCTCAAAGAGCCAAGCCCTC
AATGTCAGGCTGCACCTCCCCCTGCCTCGAGGGGTGGTCAGCCTGTCTCAGGAGCTGAGCAGCCCAGAGCAGAAGGCTGAGCTGGCAGAG
GGAGCCCTTCGCTGGGACCTGCCTCGGGTGCAAGGAGGCTCTCAACTCTCAGGCCTTTTCCAGTCTCGGAAGGGTGCTGACCTGGACCGG
GAGAAGAAGGCTGCCGAGTGCAAGGTGGACAGCATCGGGAGCGGCCGCGCCATCCCCATCAAGCAGGGGATCCTGCTAAAGCGGAGCGGC
AAGTCCCTGAACAAGGAGTGGAAGAAGAAGTATGTGACGCTCTGTGACAACGGGCTGCTCACCTATCACCCCAGCCTGCATGATTACATG
CAGAACATCCACGGCAAGGAGATTGACCTGCTGCGGACAACGGTGAAAGTGCCAGGGAAGCGCCTGCCCCGAGCCACACCTGCCACAGCC
CCGGGCACCAGCCCCCGTGCCAACGGGCTGTCCGTGGAGCGGAGTAACACACAGCTGGGTGGGGGCACAGAGGCAGAGGAGTCGTTTGAA
TTTGTGGTGGTGTCCCTCACTGGGCAGACGTGGCACTTCGAGGCTTCAACGGCGGAGGAGCGGGAGCTGTGGGTTCAGAGTGTGCAGGCC
CAGATCCTTGCCAGCCTGCAAGGCTGCCGCAGTGCCAAGGACAAGACTCGACTGGGGAACCAGAACGCAGCTCTGGCTGTGCAGGCCGTC
CGCACCGTCCGCGGCAACAGCTTTTGTATCGACTGCGATGCACCCAATCCAGACTGGGCCAGCCTGAACCTGGGTGCCCTGATGTGCATT
GAGTGCTCAGGCATCCACCGACACCTGGGGGCTCACCTGTCCCGGGTGCGCTCCCTTGACCTCGATGACTGGCCGCCTGAGCTGCTGGCT
GTCATGACTGCCATGGGCAATGCCCTCGCCAACAGCGTCTGGGAGGGGGCCTTGGGTGGCTACTCCAAGCCAGGGCCTGATGCCTGCAGA
GAGGAGAAGGAACGCTGGATACGGGCCAAGTATGAACAGAAGCTCTTCCTGGCCCCACTGCCAAGCTCAGATGTGCCACTGGGGCAGCAG
CTGCTCCGGGCCGTGGTGGAAGATGACCTGCGGCTGTTGGTGATGCTCCTGGCACATGGCTCCAAAGAGGAGGTGAATGAGACCTATGGG
GACGGGGACGGGCGGACGGCTCTACATCTCTCCAGTGCCATGGCCAACGTTGTCTTCACGCAGCTGCTCATCTGGTACGGGGTGGACGTG
AGGAGCCGGGACGCCCGGGGCCTGACTCCACTGGCATATGCTCGCCGGGCCGGCAGCCAGGAGTGTGCAGACATCTTGATCCAGCATGGC
TGCCCTGGGGAGGGCTGTGGCTTAGCGCCTACCCCCAACAGAGAGCCTGCCAATGGCACCAACCCCTCTGCTGAGCTGCACCGTAGTCCT
AGCCTCCTATAAGGCCCAGGAAGAGGGCAGAGGGGCCAGAAGGACTCCATGGCCCAAAGACCCTCCTCCCTGCAGGCACTGTGGGAACAG
ACACAGAGATGGAGAAGCAGGGACATGCTGAGAGGACGAAGCCAAGGAAATTAGGGAGGAGAGTCAAAGGGATCAAGGAGAGTTGGGGAT
TTGAGCTGCAGCAGAGAGGGATGAGGGATTTAGCCCTCTGCCCTAAGGTGCCATTGAAAAGGGACAGGACCCTTCGGAGGTGCCTGTGAG
GAGAGGGGAGCAGGACCTCTCCCTCCTCCAGATCCCTGCCTCCTAGTGCCAGCCCCTCACACGCCTTCATCCTGAAACAGGAAGAGGACG
GCACCAAGTTGGGGGTGCTGGATGAAAGAGACGAGGGGTGATCTGTGAGTCCCATGTAAACTTTGTACATTGGAATATTTATGTTTGTGT

>In-frame_ENST00000422582_ENST00000463381_AK131236_AP4M1_chr7_99704137_+_AGAP3_chr7_150820875_length(amino acids)=772AA_start in transcript=303_stop in transcript=2621
MGDRARLPLGHHHGRHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEM
LRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSF
LPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSG
RLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQSRKGADLDREKKAAECKVDS
IGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLS
VERSNTQLGGGTEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCID
CDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKY
EQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AP4M1-AGAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AP4M1-AGAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AP4M1-AGAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAP4M1C2752008Spastic Paraplegia-50, Autosomal Recessive2CTD_human;GENOMICS_ENGLAND
HgeneAP4M1C0020796Profound Mental Retardation1CTD_human
HgeneAP4M1C0025363Mental Retardation, Psychosocial1CTD_human
HgeneAP4M1C0917816Mental deficiency1CTD_human
HgeneAP4M1C3714756Intellectual Disability1CTD_human
HgeneAP4M1C4755264Severe intellectual disability and progressive spastic paraplegia1ORPHANET