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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MNT-PQLC1 (FusionGDB2 ID:54149)

Fusion Gene Summary for MNT-PQLC1

Fusion gene summary

Fusion gene information	Fusion gene name: MNT-PQLC1
	Fusion gene ID: 54149
		Hgene	Tgene
	Gene symbol	MNT	PQLC1
	Gene ID	4335	80148
	Gene name	MAX network transcriptional repressor	solute carrier family 66 member 2
	Synonyms	MAD6\|MXD6\|ROX\|bHLHd3\|lncRNA-HAL	PQLC1
	Cytomap	17p13.3	18q23
	Type of gene	protein-coding	protein-coding
	Description	max-binding protein MNTMAX binding proteinMNT, MAX dimerization proteinMax-interacting proteinclass D basic helix-loop-helix protein 3myc antagonist MNT	solute carrier family 66 member 2PQ loop repeat containing 1PQ-loop repeat-containing protein 1
	Modification date	20200314	20200313
	UniProtAcc	Q99583	.
	Ensembl transtripts involved in fusion gene	ENST00000174618, ENST00000575374, ENST00000575394,	ENST00000357575, ENST00000397778, ENST00000409073, ENST00000590381, ENST00000590895,
Fusion gene scores	* DoF score	4 X 4 X 3=48	6 X 5 X 4=120
	# samples	4	7
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MNT [Title/Abstract] AND PQLC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MNT(2297337)-PQLC1(77664183), # samples:1
Anticipated loss of major functional domain due to fusion event.	MNT-PQLC1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. MNT-PQLC1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MNT	GO:0000122	negative regulation of transcription by RNA polymerase II	9184233

Fusion gene breakpoints across MNT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PQLC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-7722-01A	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-

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Fusion Gene ORF analysis for MNT-PQLC1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000174618	ENST00000357575	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
Frame-shift	ENST00000174618	ENST00000397778	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
In-frame	ENST00000174618	ENST00000409073	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
In-frame	ENST00000174618	ENST00000590381	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
5CDS-5UTR	ENST00000174618	ENST00000590895	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
intron-3CDS	ENST00000575374	ENST00000357575	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
intron-3CDS	ENST00000575374	ENST00000397778	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
intron-3CDS	ENST00000575374	ENST00000409073	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
intron-3CDS	ENST00000575374	ENST00000590381	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
intron-5UTR	ENST00000575374	ENST00000590895	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
intron-3CDS	ENST00000575394	ENST00000357575	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
intron-3CDS	ENST00000575394	ENST00000397778	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
intron-3CDS	ENST00000575394	ENST00000409073	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
intron-3CDS	ENST00000575394	ENST00000590381	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-
intron-5UTR	ENST00000575394	ENST00000590895	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000174618	MNT	chr17	2297337	-	ENST00000409073	PQLC1	chr18	77664183	-	2976	1213	328	1245	305
ENST00000174618	MNT	chr17	2297337	-	ENST00000590381	PQLC1	chr18	77664183	-	1951	1213	328	1245	305

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000174618	ENST00000409073	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-	0.026114445	0.97388554
ENST00000174618	ENST00000590381	MNT	chr17	2297337	-	PQLC1	chr18	77664183	-	0.036402848	0.9635971

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Fusion Genomic Features for MNT-PQLC1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MNT-PQLC1

Go to
FGviewer for the breakpoints of chr17:2297337-chr18:77664183
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MNT Q99583	.
FUNCTION: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MNT

chr17:2297337

chr18:77664183

ENST00000174618

220_271

269.0

583.0

Domain

bHLH

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000590381

178_233

112.33333333333333

133.0

Domain

Note=PQ-loop 2

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000397778

232_252

202.66666666666666

272.0

Transmembrane

Helical

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000590381

145_165

112.33333333333333

133.0

Transmembrane

Helical

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000590381

168_188

112.33333333333333

133.0

Transmembrane

Helical

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000590381

232_252

112.33333333333333

133.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MNT

chr17:2297337

chr18:77664183

ENST00000174618

271_299

269.0

583.0

Region

Note=Leucine-zipper

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000397778

14_80

202.66666666666666

272.0

Domain

Note=PQ-loop 1

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000397778

178_233

202.66666666666666

272.0

Domain

Note=PQ-loop 2

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000590381

14_80

112.33333333333333

133.0

Domain

Note=PQ-loop 1

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000397778

145_165

202.66666666666666

272.0

Transmembrane

Helical

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000397778

168_188

202.66666666666666

272.0

Transmembrane

Helical

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000397778

49_69

202.66666666666666

272.0

Transmembrane

Helical

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000397778

76_96

202.66666666666666

272.0

Transmembrane

Helical

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000397778

8_28

202.66666666666666

272.0

Transmembrane

Helical

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000590381

49_69

112.33333333333333

133.0

Transmembrane

Helical

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000590381

76_96

112.33333333333333

133.0

Transmembrane

Helical

Tgene

PQLC1

chr17:2297337

chr18:77664183

ENST00000590381

8_28

112.33333333333333

133.0

Transmembrane

Helical

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Fusion Gene Sequence for MNT-PQLC1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000174618_ENST00000409073_TCGA-BR-7722-01A_MNT_chr17_2297337_-_PQLC1_chr18_77664183_length(transcript)=2976nt_BP=1213nt
CGGCGGCCGGGGGCAGCGCGGCTCCTTCCCTTGTTGTGTGTGTCGGTGCCTCCTCGCCATCTTGTTGCAAAGCCCTTTCTTGTCGGCGGG
ACTCCCGGGGGCCGCGGGGCGGGAGGCATCGGAAGGGAGGTAGAGAGGGAGGGGAAGAAGGGAGGCAGTGCCGCCTTTTTTTTTTTTTTG
CATCCCATTTTTTTAAATTTGCAATTTTATATTTTGCAAATATTTTGAGAGACATTGATTTTTCTCCCCGTGCTCCCCCGTTCTTCCCTG
CGGAGTGCGCTGCGCCGCCCAGCCCTGTCGCCCCCCGGAGGTGATCCCTCCCTCCTGCCTGCCCGCCAGCCTGACCTGTGCCCGGCTCGC
GGGCCGCAGCCTCGGCCCCGGCGCGCCCCCGGCAGCTCTCGGCGCGATGAGCATAGAGACGCTACTGGAGGCGGCCCGCTTCCTGGAATG
GCAAGCGCAGCAACAACAGAGAGCACGTGAGGAGCAGGAGCGGCTTCGCTTGGAGCAGGAGCGAGAGCAGGAACAGAAGAAGGCCAATAG
CCTGGCCAGGCTGGCACATACCCTTCCTGTGGAGGAACCCCGCATGGAGGCGCCACCCCTGCCTCTGTCTCCACCGGCTCCCCCGCCGGC
ACCCCCACCACCACTTGCCACCCCTGCCCCACTGACTGTCATCCCTATCCCTGTGGTGACCAACTCCCCTCAGCCTCTACCCCCACCCCC
ACCCTTGCCCGCGGCAGCCCAGCCTCTGCCCCTGGCGCCTCGTCAGCCGGCCCTGGTTGGCGCCCCCGGACTCAGCATTAAGGAGCCTGC
CCCCCTGCCCAGCAGGCCGCAGGTGCCCACCCCTGCTCCCCTACTGCCGGACTCGAAGGCCACCATTCCACCCAATGGCAGCCCCAAGCC
TTTGCAGCCCCTCCCCACGCCTGTCCTGACCATAGCGCCACACCCTGGAGTCCAGCCTCAGCTGGCCCCCCAGCAGCCGCCCCCACCCAC
GCTGGGGACCCTGAAGTTGGCACCAGCTGAAGAAGTCAAATCCAGTGAACAGAAGAAGAGGCCCGGGGGGATCGGAACCAGAGAAGTCCA
CAACAAATTGGAGAAGAACAGGAGGGCCCATCTGAAAGAGTGCTTTGAGACCCTGAAGCGGAACATCCCCAACGTGGATGACAAGAAGAC
GTCCAATCTGAGCGTGCTGCGGACGGCGCTGCGGTACATCCAGCATCAAGATGGTGCTCATGTGGACCAGTGGTGACGCCTTCAAGACGG
CCTACTTCCTGCTGAAGGGTGCCCCTCTGCAGTTCTCCGTGTGCGGCCTGCTGCAGGTGCTGGTGGACCTGGCCATCCTGGGGCAGGCCT
ACGCCTTCGCCCGCCACCCCCAGAAGCCGGCGCCCCACGCCGTGCACCCCACTGGCACCAAGGCCCTCTGACAGTGGGGAGGACGAGGAT
GTGGGACCGCCAGCCGCGGGCACTGGTGGGCCCTGACCTCCCCGCGGGGAGGGTGGGTGCTGTGGCCCCTGCAGGTGTGGCAGAGATGGG
GCATGGGCATTGGGGTCTCCATCAGCCTCTGTGGGGTGTCTCAGGGTGGGCAGTGGGGGTGGGGCTGGGACGCTGTTTGTGCTCAGCGGG
GACAGCCAGGGTTGATCTGGCCCCGAGGGTTTTGGATGTTTTTAGGATGACATAAAAAGCAAGTGTTTTCCCCATTTCCTCTTATGAAAC
ACCGTCTGAGCCCAAGGTACACATTGGGCGGCCTGCAGGAACCTGCTCCAGGTGGACACACGGGCCAGCAGCCGCGAACCTTGAAGCTGG
GGTGACCGCAGGAGACCCTGTAAGGCCTGTGAGCGGAGCCCTCGACCCCGTGACACCCTGGCCAGACACCCTGCTTGGACTGGGGTGGCC
TCTGCTACCCAGGGGTCTGGCACGGGGGAGGGCTGGGGCTTTCTCTGCCTGGTACACACGGAAAGGCGGCTGTGCGGACGCAGGGTCACC
GTGCTCCGGGTTTTCTGACAGTCGGTGTTTCCTGGGCCTTTGGAGTGGCTGCGAGGCCTGAACGCCTTGTGGATCCGCTGTGTCCAGCCC
GGCTGAGCATCGCCAGGGCTAGCTCATGCTGCTCTTGTCAGCCTCTGGTTCTCCTCGAGTCCTTGGGGACGTGGCAGATGCCAGCGACCA
TCAGACAACGTGGAGGCCCTCATGGGCAATGGCTGAGGGGGCCGGGCTGAGGCTGTGCACATGCAGTCTGCACGCCACTCTTGGGCTCTG
CTGGCGGAGATCCCCTTCCTTCTGGGTGCAGACTGCACCTCCGGATGCAGTTTTGATGTCCATCTTCCAGGAGAGACGGTCTCGGGTCCA
GGGAGTGGAGGGGGCTGCCCCTGCCGTGCAGGTCCTGGCCGATGGCGCCTTACCCTGCTGCCCTGGGCTTTTGGCCTGAAGCAAATTCCT
GAGTGGGGGGTACTGGGGCCTGCCGCATCCTGTCCTGTCCACTGCCCACCCCCGTGTGCTGGCTCCCTCACTTCTGGCTGCAGTGGGAGC
CGCCAGTCTGACCCTTGTCACCGCACGCTCTGCCCCCACCCCGTTGCAAGAGGTCACACCATGTCAGCAGCCTTGCACTGACCGCAGCCG
GCCCCCAGGCCTCAGAGTTCTGGATGCTTCCGTGCGGCTCCAACAGGCATCGTCTTCCCTTCCGCAGGTGGAGGGGCCGCTTCCCGCAGG
CATCTGAGCTCTGTGCCGGGGCCGTGGCCATGGGAAGATGTTCCACGCTGCCTCCTCCTCGAGTTTTCCTCGGAAACACTCTTGAATGTC
TGAGTGAGGGTCCTGCTTAGCTCTTTGGCCTGTGAGATGCTTTGAAAATTTTTATTTTTTTAAGATGAAGCAAGATGTCTGTAGCGGTAA
TTGCCTCACATTAAACTGTCGCCGACTGCAGGCGCAGTGACTGCTGAATGTACCCTGTGTGGCGACTTGGAATCAATAAACCATTTGTGG

>In-frame_ENST00000174618_ENST00000409073_TCGA-BR-7722-01A_MNT_chr17_2297337_-_PQLC1_chr18_77664183_length(amino acids)=305AA_start in transcript=328_stop in transcript=1245
MPASLTCARLAGRSLGPGAPPAALGAMSIETLLEAARFLEWQAQQQQRAREEQERLRLEQEREQEQKKANSLARLAHTLPVEEPRMEAPP
LPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQPLPPPPPLPAAAQPLPLAPRQPALVGAPGLSIKEPAPLPSRPQVPTPAPLLPDSK
ATIPPNGSPKPLQPLPTPVLTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLK

--------------------------------------------------------------
>In-frame_ENST00000174618_ENST00000590381_TCGA-BR-7722-01A_MNT_chr17_2297337_-_PQLC1_chr18_77664183_length(transcript)=1951nt_BP=1213nt
CGGCGGCCGGGGGCAGCGCGGCTCCTTCCCTTGTTGTGTGTGTCGGTGCCTCCTCGCCATCTTGTTGCAAAGCCCTTTCTTGTCGGCGGG
ACTCCCGGGGGCCGCGGGGCGGGAGGCATCGGAAGGGAGGTAGAGAGGGAGGGGAAGAAGGGAGGCAGTGCCGCCTTTTTTTTTTTTTTG
CATCCCATTTTTTTAAATTTGCAATTTTATATTTTGCAAATATTTTGAGAGACATTGATTTTTCTCCCCGTGCTCCCCCGTTCTTCCCTG
CGGAGTGCGCTGCGCCGCCCAGCCCTGTCGCCCCCCGGAGGTGATCCCTCCCTCCTGCCTGCCCGCCAGCCTGACCTGTGCCCGGCTCGC
GGGCCGCAGCCTCGGCCCCGGCGCGCCCCCGGCAGCTCTCGGCGCGATGAGCATAGAGACGCTACTGGAGGCGGCCCGCTTCCTGGAATG
GCAAGCGCAGCAACAACAGAGAGCACGTGAGGAGCAGGAGCGGCTTCGCTTGGAGCAGGAGCGAGAGCAGGAACAGAAGAAGGCCAATAG
CCTGGCCAGGCTGGCACATACCCTTCCTGTGGAGGAACCCCGCATGGAGGCGCCACCCCTGCCTCTGTCTCCACCGGCTCCCCCGCCGGC
ACCCCCACCACCACTTGCCACCCCTGCCCCACTGACTGTCATCCCTATCCCTGTGGTGACCAACTCCCCTCAGCCTCTACCCCCACCCCC
ACCCTTGCCCGCGGCAGCCCAGCCTCTGCCCCTGGCGCCTCGTCAGCCGGCCCTGGTTGGCGCCCCCGGACTCAGCATTAAGGAGCCTGC
CCCCCTGCCCAGCAGGCCGCAGGTGCCCACCCCTGCTCCCCTACTGCCGGACTCGAAGGCCACCATTCCACCCAATGGCAGCCCCAAGCC
TTTGCAGCCCCTCCCCACGCCTGTCCTGACCATAGCGCCACACCCTGGAGTCCAGCCTCAGCTGGCCCCCCAGCAGCCGCCCCCACCCAC
GCTGGGGACCCTGAAGTTGGCACCAGCTGAAGAAGTCAAATCCAGTGAACAGAAGAAGAGGCCCGGGGGGATCGGAACCAGAGAAGTCCA
CAACAAATTGGAGAAGAACAGGAGGGCCCATCTGAAAGAGTGCTTTGAGACCCTGAAGCGGAACATCCCCAACGTGGATGACAAGAAGAC
GTCCAATCTGAGCGTGCTGCGGACGGCGCTGCGGTACATCCAGCATCAAGATGGTGCTCATGTGGACCAGTGGTGACGCCTTCAAGACGG
CCTACTTCCTGCTGAAGGGTGCCCCTCTGCAGTTCTCCGTGTGCGGCCTGCTGCAGGTGCTGGTGGACCTGGCCATCCTGGGGCAGGCCT
ACGCCTTCGCCCGCCACCCCCAGAAGCCGGCGCCCCACGCCGTGCACCCCACTGGCACCAAGGCCCTCTGACAGTGGGGAGGACGAGGAT
GTGGGACCGCCAGCCGCGGGCACTGGTGGGCCCTGACCTCCCCGCGGGGAGGGTGGGTGCTGTGGCCCCTGCAGGTGTGGCAGAGATGGG
GCATGGGCATTGGGGTCTCCATCAGCCTCTGTGGGGTGTCTCAGGGTGGGCAGTGGGGGTGGGGCTGGGACGCTGTTTGTGCTCAGCGGG
GACAGCCAGGGTTGATCTGGCCCCGAGGGTTTTGGATGTTTTTAGGATGACATAAAAAGCAAGTGTTTTCCCCATTTCCTCTTATGAAAC
ACCGTCTGAGCCCAAGGTACACATTGGGCGGCCTGCAGGAACCTGCTCCAGGTGGACACACGGGCCAGCAGCCGCGAACCTTGAAGCTGG
GGTGACCGCAGGAGACCCTGTAAGGCCTGTGAGCGGAGCCCTCGACCCCGTGACACCCTGGCCAGACACCCTGCTTGGACTGGGGTGGCC

>In-frame_ENST00000174618_ENST00000590381_TCGA-BR-7722-01A_MNT_chr17_2297337_-_PQLC1_chr18_77664183_length(amino acids)=305AA_start in transcript=328_stop in transcript=1245
MPASLTCARLAGRSLGPGAPPAALGAMSIETLLEAARFLEWQAQQQQRAREEQERLRLEQEREQEQKKANSLARLAHTLPVEEPRMEAPP
LPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQPLPPPPPLPAAAQPLPLAPRQPALVGAPGLSIKEPAPLPSRPQVPTPAPLLPDSK
ATIPPNGSPKPLQPLPTPVLTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MNT-PQLC1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MNT-PQLC1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MNT-PQLC1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MNT	C0008925	Cleft Palate	1	CTD_human
Hgene	MNT	C0265219	Miller Dieker syndrome	1	CTD_human
Hgene	MNT	C0376634	Craniofacial Abnormalities	1	CTD_human
Hgene	MNT	C0431375	Classical Lissencephaly	1	CTD_human
Hgene	MNT	C1837218	Cleft palate, isolated	1	CTD_human
Hgene	MNT	C1848199	X-Linked Lissencephaly	1	CTD_human
Hgene	MNT	C1848201	Subcortical Band Heterotopia	1	CTD_human
Hgene	MNT	C1955870	Classical Lissencephalies and Subcortical Band Heterotopias	1	CTD_human
Hgene	MNT	C4551968	Lissencephaly, X-Linked, 1	1	CTD_human