FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MOV10-MOV10 (FusionGDB2 ID:54318)

Fusion Gene Summary for MOV10-MOV10

check button Fusion gene summary
Fusion gene informationFusion gene name: MOV10-MOV10
Fusion gene ID: 54318
HgeneTgene
Gene symbol

MOV10

MOV10

Gene ID

4343

4343

Gene nameMov10 RISC complex RNA helicaseMov10 RISC complex RNA helicase
SynonymsfSAP113|gb110fSAP113|gb110
Cytomap

1p13.2

1p13.2

Type of geneprotein-codingprotein-coding
Descriptionhelicase MOV-10Mov10, Moloney leukemia virus 10, homologarmitage homologfunctional spliceosome-associated protein 113moloney leukemia virus 10 proteinputative helicase MOV-10helicase MOV-10Mov10, Moloney leukemia virus 10, homologarmitage homologfunctional spliceosome-associated protein 113moloney leukemia virus 10 proteinputative helicase MOV-10
Modification date2020032020200320
UniProtAcc

Q9HCE1

Q9BXT6

Ensembl transtripts involved in fusion geneENST00000413052, ENST00000369645, 
ENST00000544796, ENST00000369644, 
ENST00000468624, ENST00000357443, 
ENST00000413052, ENST00000369645, 
ENST00000544796, ENST00000369644, 
ENST00000468624, ENST00000357443, 
Fusion gene scores* DoF score6 X 6 X 3=1086 X 6 X 2=72
# samples 66
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MOV10 [Title/Abstract] AND MOV10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMOV10(113232260)-MOV10(113232666), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMOV10

GO:0010526

negative regulation of transposition, RNA-mediated

23093941|30122351

HgeneMOV10

GO:0035279

mRNA cleavage involved in gene silencing by miRNA

16289642

HgeneMOV10

GO:0061014

positive regulation of mRNA catabolic process

24726324

HgeneMOV10

GO:0061158

3'-UTR-mediated mRNA destabilization

24726324

TgeneMOV10

GO:0010526

negative regulation of transposition, RNA-mediated

23093941|30122351

TgeneMOV10

GO:0035279

mRNA cleavage involved in gene silencing by miRNA

16289642

TgeneMOV10

GO:0061014

positive regulation of mRNA catabolic process

24726324

TgeneMOV10

GO:0061158

3'-UTR-mediated mRNA destabilization

24726324


check buttonFusion gene breakpoints across MOV10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MOV10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI752780MOV10chr1

113232260

-MOV10chr1

113232666

+


Top

Fusion Gene ORF analysis for MOV10-MOV10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000413052ENST00000413052MOV10chr1

113232260

-MOV10chr1

113232666

+
In-frameENST00000413052ENST00000369645MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-intronENST00000413052ENST00000544796MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-intronENST00000413052ENST00000369644MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-3UTRENST00000413052ENST00000468624MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-3UTRENST00000413052ENST00000357443MOV10chr1

113232260

-MOV10chr1

113232666

+
In-frameENST00000369645ENST00000413052MOV10chr1

113232260

-MOV10chr1

113232666

+
In-frameENST00000369645ENST00000369645MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-intronENST00000369645ENST00000544796MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-intronENST00000369645ENST00000369644MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-3UTRENST00000369645ENST00000468624MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-3UTRENST00000369645ENST00000357443MOV10chr1

113232260

-MOV10chr1

113232666

+
intron-3CDSENST00000544796ENST00000413052MOV10chr1

113232260

-MOV10chr1

113232666

+
intron-3CDSENST00000544796ENST00000369645MOV10chr1

113232260

-MOV10chr1

113232666

+
intron-intronENST00000544796ENST00000544796MOV10chr1

113232260

-MOV10chr1

113232666

+
intron-intronENST00000544796ENST00000369644MOV10chr1

113232260

-MOV10chr1

113232666

+
intron-3UTRENST00000544796ENST00000468624MOV10chr1

113232260

-MOV10chr1

113232666

+
intron-3UTRENST00000544796ENST00000357443MOV10chr1

113232260

-MOV10chr1

113232666

+
In-frameENST00000369644ENST00000413052MOV10chr1

113232260

-MOV10chr1

113232666

+
In-frameENST00000369644ENST00000369645MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-intronENST00000369644ENST00000544796MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-intronENST00000369644ENST00000369644MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-3UTRENST00000369644ENST00000468624MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-3UTRENST00000369644ENST00000357443MOV10chr1

113232260

-MOV10chr1

113232666

+
3UTR-3CDSENST00000468624ENST00000413052MOV10chr1

113232260

-MOV10chr1

113232666

+
3UTR-3CDSENST00000468624ENST00000369645MOV10chr1

113232260

-MOV10chr1

113232666

+
3UTR-intronENST00000468624ENST00000544796MOV10chr1

113232260

-MOV10chr1

113232666

+
3UTR-intronENST00000468624ENST00000369644MOV10chr1

113232260

-MOV10chr1

113232666

+
3UTR-3UTRENST00000468624ENST00000468624MOV10chr1

113232260

-MOV10chr1

113232666

+
3UTR-3UTRENST00000468624ENST00000357443MOV10chr1

113232260

-MOV10chr1

113232666

+
In-frameENST00000357443ENST00000413052MOV10chr1

113232260

-MOV10chr1

113232666

+
In-frameENST00000357443ENST00000369645MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-intronENST00000357443ENST00000544796MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-intronENST00000357443ENST00000369644MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-3UTRENST00000357443ENST00000468624MOV10chr1

113232260

-MOV10chr1

113232666

+
5CDS-3UTRENST00000357443ENST00000357443MOV10chr1

113232260

-MOV10chr1

113232666

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MOV10-MOV10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MOV10-MOV10


check button Go to

FGviewer for the breakpoints of chr1:113232260-chr1:113232666

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOV10

Q9HCE1

MOV10

Q9BXT6

FUNCTION: 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30122351}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}.FUNCTION: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. {ECO:0000250|UniProtKB:Q99MV5}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMOV10chr1:113232260chr1:113232666ENST00000357443020645_64801004.0MotifNote=DEAG box
TgeneMOV10chr1:113232260chr1:113232666ENST00000369645021645_64801004.0MotifNote=DEAG box
TgeneMOV10chr1:113232260chr1:113232666ENST00000413052021645_64801004.0MotifNote=DEAG box
TgeneMOV10chr1:113232260chr1:113232666ENST0000054479603645_648057.0MotifNote=DEAG box
TgeneMOV10chr1:113232260chr1:113232666ENST00000357443020524_53101004.0Nucleotide bindingATP
TgeneMOV10chr1:113232260chr1:113232666ENST00000369645021524_53101004.0Nucleotide bindingATP
TgeneMOV10chr1:113232260chr1:113232666ENST00000413052021524_53101004.0Nucleotide bindingATP
TgeneMOV10chr1:113232260chr1:113232666ENST0000054479603524_531057.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMOV10chr1:113232260chr1:113232666ENST00000357443-120645_64801004.0MotifNote=DEAG box
HgeneMOV10chr1:113232260chr1:113232666ENST00000369645-121645_64801004.0MotifNote=DEAG box
HgeneMOV10chr1:113232260chr1:113232666ENST00000413052-121645_64801004.0MotifNote=DEAG box
HgeneMOV10chr1:113232260chr1:113232666ENST00000544796-13645_648057.0MotifNote=DEAG box
HgeneMOV10chr1:113232260chr1:113232666ENST00000357443-120524_53101004.0Nucleotide bindingATP
HgeneMOV10chr1:113232260chr1:113232666ENST00000369645-121524_53101004.0Nucleotide bindingATP
HgeneMOV10chr1:113232260chr1:113232666ENST00000413052-121524_53101004.0Nucleotide bindingATP
HgeneMOV10chr1:113232260chr1:113232666ENST00000544796-13524_531057.0Nucleotide bindingATP


Top

Fusion Gene Sequence for MOV10-MOV10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MOV10-MOV10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMOV10chr1:113232260chr1:113232666ENST00000357443020921_96501004.0AGO2 and APOBEC3G
TgeneMOV10chr1:113232260chr1:113232666ENST00000369645021921_96501004.0AGO2 and APOBEC3G
TgeneMOV10chr1:113232260chr1:113232666ENST00000413052021921_96501004.0AGO2 and APOBEC3G
TgeneMOV10chr1:113232260chr1:113232666ENST0000054479603921_965057.0AGO2 and APOBEC3G


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMOV10chr1:113232260chr1:113232666ENST00000357443-120921_96501004.0AGO2 and APOBEC3G
HgeneMOV10chr1:113232260chr1:113232666ENST00000369645-121921_96501004.0AGO2 and APOBEC3G
HgeneMOV10chr1:113232260chr1:113232666ENST00000413052-121921_96501004.0AGO2 and APOBEC3G
HgeneMOV10chr1:113232260chr1:113232666ENST00000544796-13921_965057.0AGO2 and APOBEC3G


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MOV10-MOV10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MOV10-MOV10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource