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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MOV10-SYCP1 (FusionGDB2 ID:54322) |
Fusion Gene Summary for MOV10-SYCP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MOV10-SYCP1 | Fusion gene ID: 54322 | Hgene | Tgene | Gene symbol | MOV10 | SYCP1 | Gene ID | 4343 | 6847 |
| Gene name | Mov10 RISC complex RNA helicase | synaptonemal complex protein 1 | |
| Synonyms | fSAP113|gb110 | CT8|HOM-TES-14|SCP-1|SCP1 | |
| Cytomap | 1p13.2 | 1p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | helicase MOV-10Mov10, Moloney leukemia virus 10, homologarmitage homologfunctional spliceosome-associated protein 113moloney leukemia virus 10 proteinputative helicase MOV-10 | synaptonemal complex protein 1cancer/testis antigen 8testicular tissue protein Li 191 | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | Q9HCE1 | Q15431 | |
| Ensembl transtripts involved in fusion gene | ENST00000413052, ENST00000369645, ENST00000544796, ENST00000369644, ENST00000468624, ENST00000357443, | ENST00000369522, ENST00000369518, ENST00000477590, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 4 X 4 X 4=64 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MOV10 [Title/Abstract] AND SYCP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MOV10(113232720)-SYCP1(115438069), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | MOV10-SYCP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MOV10-SYCP1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MOV10 | GO:0010526 | negative regulation of transposition, RNA-mediated | 23093941|30122351 |
| Hgene | MOV10 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA | 16289642 |
| Hgene | MOV10 | GO:0061014 | positive regulation of mRNA catabolic process | 24726324 |
| Hgene | MOV10 | GO:0061158 | 3'-UTR-mediated mRNA destabilization | 24726324 |
| Tgene | SYCP1 | GO:0051289 | protein homotetramerization | 29915389 |
| Fusion gene breakpoints across MOV10 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across SYCP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | READ | TCGA-EI-6883-01A | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| ChimerDB4 | READ | TCGA-EI-6883-01A | MOV10 | chr1 | 113232720 | - | SYCP1 | chr1 | 115438069 | + |
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Fusion Gene ORF analysis for MOV10-SYCP1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000413052 | ENST00000369522 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| Frame-shift | ENST00000413052 | ENST00000369518 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| 5CDS-intron | ENST00000413052 | ENST00000477590 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| Frame-shift | ENST00000369645 | ENST00000369522 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| Frame-shift | ENST00000369645 | ENST00000369518 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| 5CDS-intron | ENST00000369645 | ENST00000477590 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| intron-3CDS | ENST00000544796 | ENST00000369522 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| intron-3CDS | ENST00000544796 | ENST00000369518 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| intron-intron | ENST00000544796 | ENST00000477590 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| Frame-shift | ENST00000369644 | ENST00000369522 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| Frame-shift | ENST00000369644 | ENST00000369518 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| 5CDS-intron | ENST00000369644 | ENST00000477590 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| 3UTR-3CDS | ENST00000468624 | ENST00000369522 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| 3UTR-3CDS | ENST00000468624 | ENST00000369518 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| 3UTR-intron | ENST00000468624 | ENST00000477590 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| Frame-shift | ENST00000357443 | ENST00000369522 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| Frame-shift | ENST00000357443 | ENST00000369518 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| 5CDS-intron | ENST00000357443 | ENST00000477590 | MOV10 | chr1 | 113232720 | + | SYCP1 | chr1 | 115438069 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for MOV10-SYCP1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MOV10-SYCP1 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MOV10 | SYCP1 |
| FUNCTION: 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30122351}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}. | FUNCTION: Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. {ECO:0000250|UniProtKB:Q62209}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MOV10-SYCP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for MOV10-SYCP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MOV10-SYCP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MOV10-SYCP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SYCP1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Tgene | SYCP1 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| Tgene | SYCP1 | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human |
| Tgene | SYCP1 | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human |
| Tgene | SYCP1 | C0205643 | Carcinoma, Cribriform | 1 | CTD_human |
| Tgene | SYCP1 | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human |
| Tgene | SYCP1 | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human |
| Tgene | SYCP1 | C0346647 | Malignant neoplasm of pancreas | 1 | CTD_human |
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