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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:MPHOSPH9-CDK2AP1 (FusionGDB2 ID:54377) |
Fusion Gene Summary for MPHOSPH9-CDK2AP1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MPHOSPH9-CDK2AP1 | Fusion gene ID: 54377 | Hgene | Tgene | Gene symbol | MPHOSPH9 | CDK2AP1 | Gene ID | 10198 | 8099 |
Gene name | M-phase phosphoprotein 9 | cyclin dependent kinase 2 associated protein 1 | |
Synonyms | MPP-9|MPP9 | DOC1|DORC1|ST19|doc-1|p12DOC-1 | |
Cytomap | 12q24.31 | 12q24.31 | |
Type of gene | protein-coding | protein-coding | |
Description | M-phase phosphoprotein 9 | cyclin-dependent kinase 2-associated protein 1CDK2-associated protein 1Deleted in oral cancer-1deleted in oral cancer 1putative oral cancer suppressor | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q99550 | O14519 | |
Ensembl transtripts involved in fusion gene | ENST00000302349, ENST00000541076, ENST00000606320, ENST00000392425, ENST00000539639, | ENST00000261692, ENST00000538446, ENST00000535979, ENST00000542174, ENST00000544658, | |
Fusion gene scores | * DoF score | 14 X 13 X 8=1456 | 9 X 5 X 5=225 |
# samples | 13 | 9 | |
** MAII score | log2(13/1456*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/225*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MPHOSPH9 [Title/Abstract] AND CDK2AP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MPHOSPH9(123645328)-CDK2AP1(123751829), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | MPHOSPH9-CDK2AP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MPHOSPH9-CDK2AP1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. MPHOSPH9-CDK2AP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CDK2AP1 | GO:0001934 | positive regulation of protein phosphorylation | 9506968 |
Fusion gene breakpoints across MPHOSPH9 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across CDK2AP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | CESC | TCGA-DS-A1O9-01A | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
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Fusion Gene ORF analysis for MPHOSPH9-CDK2AP1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000302349 | ENST00000261692 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000302349 | ENST00000538446 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000302349 | ENST00000535979 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000302349 | ENST00000542174 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000302349 | ENST00000544658 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
Frame-shift | ENST00000541076 | ENST00000261692 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000541076 | ENST00000538446 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000541076 | ENST00000535979 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000541076 | ENST00000542174 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000541076 | ENST00000544658 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
In-frame | ENST00000606320 | ENST00000261692 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000606320 | ENST00000538446 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000606320 | ENST00000535979 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000606320 | ENST00000542174 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000606320 | ENST00000544658 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
Frame-shift | ENST00000392425 | ENST00000261692 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000392425 | ENST00000538446 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000392425 | ENST00000535979 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000392425 | ENST00000542174 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
5CDS-5UTR | ENST00000392425 | ENST00000544658 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
intron-3CDS | ENST00000539639 | ENST00000261692 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
intron-5UTR | ENST00000539639 | ENST00000538446 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
intron-5UTR | ENST00000539639 | ENST00000535979 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
intron-5UTR | ENST00000539639 | ENST00000542174 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
intron-5UTR | ENST00000539639 | ENST00000544658 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000606320 | MPHOSPH9 | chr12 | 123645328 | - | ENST00000261692 | CDK2AP1 | chr12 | 123751829 | - | 4705 | 3657 | 198 | 3743 | 1181 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000606320 | ENST00000261692 | MPHOSPH9 | chr12 | 123645328 | - | CDK2AP1 | chr12 | 123751829 | - | 0.000264526 | 0.9997354 |
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Fusion Genomic Features for MPHOSPH9-CDK2AP1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MPHOSPH9-CDK2AP1 |
Go to FGviewer for the breakpoints of chr12:123645328-chr12:123751829 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MPHOSPH9 | CDK2AP1 |
FUNCTION: specific inhibitor of the cell-cycle kinase CDK2. {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MPHOSPH9 | chr12:123645328 | chr12:123751829 | ENST00000302349 | - | 19 | 20 | 609_804 | 998.0 | 1029.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | MPHOSPH9 | chr12:123645328 | chr12:123751829 | ENST00000392425 | - | 19 | 20 | 609_804 | 998.0 | 1032.0 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | CDK2AP1 | chr12:123645328 | chr12:123751829 | ENST00000535979 | 0 | 4 | 1_60 | 0 | 88.0 | Region | Note=Intrinsically disordered | |
Tgene | CDK2AP1 | chr12:123645328 | chr12:123751829 | ENST00000538446 | 0 | 4 | 1_60 | 0 | 88.0 | Region | Note=Intrinsically disordered | |
Tgene | CDK2AP1 | chr12:123645328 | chr12:123751829 | ENST00000542174 | 0 | 3 | 1_60 | 0 | 88.0 | Region | Note=Intrinsically disordered | |
Tgene | CDK2AP1 | chr12:123645328 | chr12:123751829 | ENST00000544658 | 0 | 4 | 1_60 | 0 | 88.0 | Region | Note=Intrinsically disordered |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MPHOSPH9 | chr12:123645328 | chr12:123751829 | ENST00000302349 | - | 19 | 20 | 1109_1174 | 998.0 | 1029.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | MPHOSPH9 | chr12:123645328 | chr12:123751829 | ENST00000392425 | - | 19 | 20 | 1109_1174 | 998.0 | 1032.0 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | CDK2AP1 | chr12:123645328 | chr12:123751829 | ENST00000261692 | 0 | 4 | 1_60 | 18.333333333333332 | 116.0 | Region | Note=Intrinsically disordered |
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Fusion Gene Sequence for MPHOSPH9-CDK2AP1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000606320_ENST00000261692_TCGA-DS-A1O9-01A_MPHOSPH9_chr12_123645328_-_CDK2AP1_chr12_123751829_length(transcript)=4705nt_BP=3657nt GAGAGGCCGCTTGCATGACCCTGACATCGGCAGCGGGAGCGGCGGCCAGACTCTCTTGGAAGTTTAGGATATTTCACAGTTCTGAATGTT AGCCACTGAAAATGCCAGTAGATGATGAAGCCTCTGAAGATGACACGGATTCATTTTTCTCAAACAGCCCAAGAACCTTTATTTTCCAAT AAGAGAATATAACAATTTCTGTACACTATGGAAGAGTTTGACTTGGTGAAAACCTTACACAAAACTTCATCTTCTGTAGGATCTGATGAA AATTCTCTTCATTCTCTTGGACTGAACTTAAATACTGATAGAAGTAGTCCCCACCTTAGTACAAATGGGGTATCCTCTTTCTCAGGGAAG ACCAGACCATCTGTAATTCAAGGTACAGTTGAAGTCCTAACTTCTTTAATGCAAGAGCTACAAAACAGTGGAAAGACTGATTCGGAACTT TGGAAAAACTGTGAGACCAGGTGGTTACAGCTATTCAATTTGGTGGAAAAACAATGCCAAGAACAGATAGTTGCCCAGCAGGAGCAGTTC CACAACCAAATTCAACATATACAGGAGGAGATAAAAAATTTAGTCAAATTACAGACTAGTAGTGCTTCCTTAGCTTCCTGTGAAGGAAAT TCTTCAAACAAACAAGTATCTTCGGAAAGTCAAATGGGTTTTTTTTCTCTAAGCAGTGAGAGAAATGAATCTGTTATCCATTATCCTGAA TCCACAGAACCTGAAATACAGCAAGAAATGTCCACGTCACAACCAGACTGCAATGTGGATAGTTGCTCAGTAAGCAGTGGATATGGCACC TTTTGTATCTCAGAATTAAATCTGTACAAATCTAAAGACCCTAAGGAGTTCATGGAGCACATAGATGTTCCCAAAGGACAGTATGTAGCA CCTGCGGTGCCGGCTGAGTCACTTGTAGATGGTGTGAAAAATGAGAATTTTTATATACAGACTCCTGAAGAGTGTCATGTGTCTTTAAAG GAAGATGTATCCATTTCTCCTGGTGAATTTGAACATAATTTTCTTGGTGAAAATAAGGTTTCTGAAGTATACAGTGGGAAAACAAATAGT AATGCTATAACATCATGGGCACAAAAACTGAAGCAGAACCAACCAAAGAGAGCACATGTAGAAGATGGAGGTTCAAGATCTAAACAAGGA AATGAGCAAAGTAAGAAGACACCAATTGAGAAATCTGATTTTGCTGCTGCTACACATCCTCGTGCTTTTTACCTCAGTAAACCAGATGAA ACTCCAAATGCTTGGATGTCTGATTCAGGAACAGGATTGACTTACTGGAAACTAGAGGAAAAGGATATGCACCACTCTTTGCCTGAAACT TTAGAGAAGACGTTCATATCATTGTCTTCCACAGATGTGTCACCAAACCAGTCTAATACTAGTAATGAGATGAAGCTACCGTCACTGAAG GATATTTATTATAAAAAACAAAGGGAAAACAAGCAGTTACCTGAGAGGAATCTCACTTCTGCTTCCAACCCAAATCATCCACCAGAGGTC CTGACTCTAGATCCTACGTTACACATGAAGCCAAAGCAGCAGATTTCAGGGATTCAACCTCACGGCCTTCCGAATGCCCTTGATGACAGA ATATCCTTTTCCCCGGACTCTGTTCTAGAGCCTAGTATGTCTAGTCCCTCTGACATAGACTCATTTTCACAAGCAAGTAATGTCACTTCT CAGTTACCTGGATTTCCAAAATATCCCTCACACACAAAAGCTTCTCCGGTGGACTCTTGGAAAAATCAGACATTCCAAAACGAAAGTAGG ACCAGTTCCACGTTTCCGTCAGTATATACCATTACTAGTAATGATATCTCGGTCAACACTGTAGATGAAGAAAACACTGTCATGGTTGCT TCGGCCTCAGTCAGTCAGTCCCAGCTTCCAGGTACAGCCAACAGTGTCCCAGAATGCATTTCATTGACTTCCTTGGAAGATCCTGTGATA TTGTCTAAGATTAGGCAGAATCTGAAGGAAAAGCATGCTCGACACATAGCAGATCTTCGAGCTTATTATGAATCAGAAATAAATAGTTTG AAACAGAAGCTGGAGGCAAAAGAAATCTCTGGAGTTGAAGATTGGAAGATAACCAATCAAATTCTTGTAGACAGATGTGGCCAATTAGAT AGTGCTTTGCATGAAGCTACTAGTCGCGTGAGAACACTTGAAAATAAGAATAACTTACTGGAAATTGAAGTGAATGATTTGAGAGAACGC TTCAGTGCAGCCAGCAGTGCTTCCAAAATTTTGCAGGAACGAATTGAAGAAATGAGAACAAGCAGTAAAGAAAAAGACAATACCATCATT CGACTAAAATCTAGACTGCAAGATTTAGAAGAAGCATTTGAGAATGCTTACAAACTCTCAGATGATAAAGAAGCTCAACTAAAACAAGAG AACAAAATGTTTCAAGATCTTTTAGGAGAGTATGAGTCCCTTGGAAAAGAACACAGGAGAGTAAAGGATGCATTAAATACAACTGAGAAC AAATTGCTTGATGCATATACTCAGATTTCTGATTTGAAAAGAATGATTTCAAAACTTGAAGCTCAGGTCAAGCAAGTAGAACATGAAAAT ATGTTAAGCCTTCGTCATAATTCTAGAATTCACGTGAGACCCTCGCGTGCCAACACACTAGCAACTTCAGACGTCAGCAGGCGGAAATGG CTGATTCCAGGTGCAGAGTATTCCATCTTTACTGGCCAGCCTCTGGACACCCAGGACAGTAACGTGGATAACCAGCTGGAGGAAACCTGT AGCCTAGGGCACCGTTCACCTCTGGAAAAGGATTCTTCACCTGGAAGTTCATCAACAAGCTTGTTGATAAAAAAGCAAAGAGAGACTTCA GACACGCCGATCATGAGAGCTTTAAAAGAACTTGATGAGGGAAAAATATTTAAAAATTGGGGGACACAGACAGAGAAAGAGGACACCTCA AATATAAATCCTCGGCAAACTGAAACTTCAGTTAATGCAAGTCGTTCTCCAGAAAAGTGTGCCCAACAGAGACAAAAGAGACTTAATTCG GCCTCACAGAGATCATCATCTTTACCACCTTCAAATCGTAAATCAAGTACTCCAACAAAAAGAGAGATTATGCTAACACCAGTGACTGTG GCTTATAGTCCAAAGCGATCCCCTAAAGAAAACTTGTCCCCAGGATTTAGTCATCTGCTTAGCAAAAATGAGAGCAGTCCAATTCGATTT GATATACTTTTGGATGATTTAGATACTGTTCCTGTGTCTACATTACAACGTACCAATCCAAGAAAGCAACTCCAGTTTCTTCCTCTAGAT GACTCGGAAGAAAAAACTTATTCTGAGAAAGCCACCGATAACCATGTTAATCATAGCTCTTGCCCTGAACCGGTGCCAAATGGAGTGAAG AAAGTATCTGTGAGAACAGCCTGGGAGAAGAATAAATCAGTTAGCTACGAACAGTGTAAGCCGGTTTCAGTCACTCCACAGGGGAATGAT TTTGAATATACAGCAAAAATTCGGACCCTAGCTGAAACAGAACGATTTTTTGATGAACTTACAAAAGAAAAGGACCAGATTGAGGCAGCA CTAAGCAGGATGCCTTCTCCTGGAGGACGAATCACTTTACAGACAAGATTAAATCAGCTGGGAGTGTCCACTCGCCTTCCACCAGCATGG CAACGTCTTCACAGTACCGCCAGCTGCTCAGTGACTACGGGCCACCGTCCCTAGGCTACACCCAGGGAACTGGGAACAGCCAGGTGCCCC AAAGCAAATACGCGGAGCTGCTGGCCATCATTGAAGAGCTGGGGAAGGAGATCAGACCCACGTACGCAGGGAGCAAGAGTGCCATGGAGA GGCTGAAGCGCGGCATCATTCACGCTAGAGGACTGGTTCGGGAGTGCTTGGCAGAAACGGAACGGAATGCCAGATCCTAGCTGCCTTGTT GGTTTTGAAGGATTTCCATCTTTTTACAAGATGAGAAGTTACAGTTCATCTCCCCTGTTCAGATGAAACCCTTGTTTTCAAAATGGTTAC AGTTTCGTTTTTCCTCCCATGGTTCACTTGGCTCTGAACCTACAGTCTCAAAGATTGAGAAAAGATTTTGCAGTTAATTAGGATTTGCAT TTTAAGTAGTTAGGAACTGCCCAGGTTTTTTTTGTTTTTTAAGCATTGATTTAAAAGATGCACGGAAAGTTATCTTACAGCAAACTGTAG TTTGCCTCCAAGACACCATTGTCTCCCTTTAATCTTCTCTTTTGTATACATTTGTTACCCATGGTGTTCTTTGTTCCTTTTCATAAGCTA ATACCACTGTAGGGATTTTGTTTTGAACGCATATTGACAGCACGCTTTACTTAGTAGCCGGTTCCCATTTGCCATACAATGTAGGTTCTG CTTAATGTAACTTCTTTTTTGCTTAAGCATTTGCATGACTATTAGTGCTTCAAAGTCAATTTTTAAAAATGCACAAGTTATAAATACAGA AGAAAGAGCAACCCACCAAACCTAACAAGGACCCCCGAACACTTTCATACTAAGACTGTAAGTAGATCTCAGTTCTGCGTTTATTGTAAG TTGATAAAAACATCTGGAAGAAAATGACTAAAACTGTTTGCATCTTTGTATGTATTTATTACTTGATGTAATAAAGCTTATTTTCATTAA >In-frame_ENST00000606320_ENST00000261692_TCGA-DS-A1O9-01A_MPHOSPH9_chr12_123645328_-_CDK2AP1_chr12_123751829_length(amino acids)=1181AA_start in transcript=198_stop in transcript=3743 MYTMEEFDLVKTLHKTSSSVGSDENSLHSLGLNLNTDRSSPHLSTNGVSSFSGKTRPSVIQGTVEVLTSLMQELQNSGKTDSELWKNCET RWLQLFNLVEKQCQEQIVAQQEQFHNQIQHIQEEIKNLVKLQTSSASLASCEGNSSNKQVSSESQMGFFSLSSERNESVIHYPESTEPEI QQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDGVKNENFYIQTPEECHVSLKEDVSIS PGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEKSDFAAATHPRAFYLSKPDETPNAWM SDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENKQLPERNLTSASNPNHPPEVLTLDPT LHMKPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSHTKASPVDSWKNQTFQNESRTSSTFP SVYTITSNDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEKHARHIADLRAYYESEINSLKQKLEA KEISGVEDWKITNQILVDRCGQLDSALHEATSRVRTLENKNNLLEIEVNDLRERFSAASSASKILQERIEEMRTSSKEKDNTIIRLKSRL QDLEEAFENAYKLSDDKEAQLKQENKMFQDLLGEYESLGKEHRRVKDALNTTENKLLDAYTQISDLKRMISKLEAQVKQVEHENMLSLRH NSRIHVRPSRANTLATSDVSRRKWLIPGAEYSIFTGQPLDTQDSNVDNQLEETCSLGHRSPLEKDSSPGSSSTSLLIKKQRETSDTPIMR ALKELDEGKIFKNWGTQTEKEDTSNINPRQTETSVNASRSPEKCAQQRQKRLNSASQRSSSLPPSNRKSSTPTKREIMLTPVTVAYSPKR SPKENLSPGFSHLLSKNESSPIRFDILLDDLDTVPVSTLQRTNPRKQLQFLPLDDSEEKTYSEKATDNHVNHSSCPEPVPNGVKKVSVRT AWEKNKSVSYEQCKPVSVTPQGNDFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQTRLNQLGVSTRLPPAWQRLHST -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MPHOSPH9-CDK2AP1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | CDK2AP1 | chr12:123645328 | chr12:123751829 | ENST00000261692 | 0 | 4 | 20_25 | 18.333333333333332 | 116.0 | CDK2AP2 | |
Tgene | CDK2AP1 | chr12:123645328 | chr12:123751829 | ENST00000535979 | 0 | 4 | 20_25 | 0 | 88.0 | CDK2AP2 | |
Tgene | CDK2AP1 | chr12:123645328 | chr12:123751829 | ENST00000538446 | 0 | 4 | 20_25 | 0 | 88.0 | CDK2AP2 | |
Tgene | CDK2AP1 | chr12:123645328 | chr12:123751829 | ENST00000542174 | 0 | 3 | 20_25 | 0 | 88.0 | CDK2AP2 | |
Tgene | CDK2AP1 | chr12:123645328 | chr12:123751829 | ENST00000544658 | 0 | 4 | 20_25 | 0 | 88.0 | CDK2AP2 |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MPHOSPH9-CDK2AP1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MPHOSPH9-CDK2AP1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |