FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MPO-EPX (FusionGDB2 ID:54406)

Fusion Gene Summary for MPO-EPX

check button Fusion gene summary
Fusion gene informationFusion gene name: MPO-EPX
Fusion gene ID: 54406
HgeneTgene
Gene symbol

MPO

EPX

Gene ID

4353

8288

Gene namemyeloperoxidaseeosinophil peroxidase
Synonyms-EPO|EPP|EPX-PEN|EPXD
Cytomap

17q22

17q22

Type of geneprotein-codingprotein-coding
Descriptionmyeloperoxidaseeosinophil peroxidase
Modification date2020032920200313
UniProtAcc.

P11678

Ensembl transtripts involved in fusion geneENST00000340482, ENST00000225275, 
ENST00000578493, 		ENST00000225371, 
Fusion gene scores* DoF score9 X 6 X 2=1082 X 2 X 2=8
# samples 82
** MAII scorelog2(8/108*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: MPO [Title/Abstract] AND EPX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMPO(56355404)-EPX(56274506), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMPO

GO:0034374

low-density lipoprotein particle remodeling

10772654

HgeneMPO

GO:0042744

hydrogen peroxide catabolic process

10772654|11907569

HgeneMPO

GO:0055114

oxidation-reduction process

10772654


check buttonFusion gene breakpoints across MPO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EPX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2830-03AMPOchr17

56355404

-EPXchr17

56274506

+
ChimerDB4LAMLTCGA-AB-2998-03AMPOchr17

56355404

-EPXchr17

56274506

+


Top

Fusion Gene ORF analysis for MPO-EPX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000340482ENST00000225371MPOchr17

56355404

-EPXchr17

56274506

+
intron-3CDSENST00000225275ENST00000225371MPOchr17

56355404

-EPXchr17

56274506

+
intron-3CDSENST00000578493ENST00000225371MPOchr17

56355404

-EPXchr17

56274506

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MPO-EPX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MPO-EPX


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EPX

P11678

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. {ECO:0000269|PubMed:12540536, ECO:0000269|PubMed:18694936}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for MPO-EPX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MPO-EPX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MPO-EPX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneEPXP11678DB01065MelatoninInhibitorSmall moleculeApproved|Nutraceutical|Vet_approved
TgeneEPXP11678DB01065MelatoninInhibitorSmall moleculeApproved|Nutraceutical|Vet_approved
TgeneEPXP11678DB01065MelatoninInhibitorSmall moleculeApproved|Nutraceutical|Vet_approved
TgeneEPXP11678DB01065MelatoninInhibitorSmall moleculeApproved|Nutraceutical|Vet_approved

Top

Related Diseases for MPO-EPX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPOC0035126Reperfusion Injury6CTD_human
HgeneMPOC0021368Inflammation5CTD_human
HgeneMPOC0398595Myeloperoxidase Deficiency5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneMPOC0009324Ulcerative Colitis3CTD_human
HgeneMPOC0003873Rheumatoid Arthritis2CTD_human
HgeneMPOC0023891Liver Cirrhosis, Alcoholic2CTD_human
HgeneMPOC0001969Alcoholic Intoxication1PSYGENET
HgeneMPOC0002152Alloxan Diabetes1CTD_human
HgeneMPOC0002395Alzheimer's Disease1CTD_human
HgeneMPOC0003129Anoxemia1CTD_human
HgeneMPOC0003130Anoxia1CTD_human
HgeneMPOC0003865Arthritis, Adjuvant-Induced1CTD_human
HgeneMPOC0005398Cholestasis, Extrahepatic1CTD_human
HgeneMPOC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneMPOC0005695Bladder Neoplasm1CTD_human
HgeneMPOC0006111Brain Diseases1CTD_human
HgeneMPOC0007222Cardiovascular Diseases1CTD_human
HgeneMPOC0007786Brain Ischemia1CTD_human
HgeneMPOC0009319Colitis1CTD_human
HgeneMPOC0011265Presenile dementia1CTD_human
HgeneMPOC0011574Involutional Depression1CTD_human
HgeneMPOC0011609Drug Eruptions1CTD_human
HgeneMPOC0011853Diabetes Mellitus, Experimental1CTD_human
HgeneMPOC0022593Keratosis1CTD_human
HgeneMPOC0022594Keratosis Blennorrhagica1CTD_human
HgeneMPOC0022658Kidney Diseases1CTD_human
HgeneMPOC0022660Kidney Failure, Acute1CTD_human
HgeneMPOC0024115Lung diseases1CTD_human
HgeneMPOC0024121Lung Neoplasms1CTD_human
HgeneMPOC0028797Occupational Diseases1CTD_human
HgeneMPOC0030305Pancreatitis1CTD_human
HgeneMPOC0032927Precancerous Conditions1CTD_human
HgeneMPOC0033578Prostatic Neoplasms1CTD_human
HgeneMPOC0036982Shock, Hemorrhagic1CTD_human
HgeneMPOC0038433Streptozotocin Diabetes1CTD_human
HgeneMPOC0040954Infection by Trichuris trichiura1CTD_human
HgeneMPOC0042109Urticaria1CTD_human
HgeneMPOC0085584Encephalopathies1CTD_human
HgeneMPOC0086501Keratoma1CTD_human
HgeneMPOC0242184Hypoxia1CTD_human
HgeneMPOC0242379Malignant neoplasm of lung1CTD_human
HgeneMPOC0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneMPOC0282313Condition, Preneoplastic1CTD_human
HgeneMPOC0376358Malignant neoplasm of prostate1CTD_human
HgeneMPOC0406537Morbilliform Drug Reaction1CTD_human
HgeneMPOC0494463Alzheimer Disease, Late Onset1CTD_human
HgeneMPOC0546126Acute Confusional Senile Dementia1CTD_human
HgeneMPOC0700292Hypoxemia1CTD_human
HgeneMPOC0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneMPOC0750901Alzheimer Disease, Early Onset1CTD_human
HgeneMPOC0917798Cerebral Ischemia1CTD_human
HgeneMPOC0971858Arthritis, Collagen-Induced1CTD_human
HgeneMPOC0993582Arthritis, Experimental1CTD_human
HgeneMPOC1269683Major Depressive Disorder1CTD_human
HgeneMPOC1565662Acute Kidney Insufficiency1CTD_human
HgeneMPOC1571983Involutional paraphrenia1CTD_human
HgeneMPOC1571984Psychosis, Involutional1CTD_human
HgeneMPOC2239176Liver carcinoma1CTD_human
HgeneMPOC2609414Acute kidney injury1CTD_human
TgeneEPXC1850000Presentey Anomaly1CTD_human;UNIPROT