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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MPV17-SIGIRR (FusionGDB2 ID:54473)

Fusion Gene Summary for MPV17-SIGIRR

check button Fusion gene summary
Fusion gene informationFusion gene name: MPV17-SIGIRR
Fusion gene ID: 54473
HgeneTgene
Gene symbol

MPV17

SIGIRR

Gene ID

4358

59307

Gene namemitochondrial inner membrane protein MPV17single Ig and TIR domain containing
SynonymsCMT2EE|MTDPS6|SYM1IL-1R8|TIR8
Cytomap

2p23.3

11p15.5

Type of geneprotein-codingprotein-coding
Descriptionprotein Mpv17MPV17, mitochondrial inner membrane proteinMpV17 mitochondrial inner membrane proteinMpv17, human homolog of glomerulosclerosis and nephrotic syndromesingle Ig IL-1-related receptorinterleukin-1 receptor 8 long isoformsingle Ig IL-1R-related moleculesingle immunoglobulin and toll-interleukin 1 receptor (TIR) domainsingle immunoglobulin domain IL1R1 relatedsingle immunoglobulin domain-containing IL
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000233545, ENST00000402310, 
ENST00000380044, ENST00000357186, 
ENST00000402722, ENST00000405983, 
ENST00000405076, ENST00000403262, 
ENST00000399052, 		ENST00000431843, 
ENST00000397632, ENST00000332725, 
ENST00000531205, ENST00000382520, 
ENST00000529486, 
Fusion gene scores* DoF score3 X 2 X 2=123 X 3 X 2=18
# samples 34
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MPV17 [Title/Abstract] AND SIGIRR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMPV17(27545315)-SIGIRR(406059), # samples:1
Anticipated loss of major functional domain due to fusion event.MPV17-SIGIRR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MPV17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SIGIRR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4QI-01AMPV17chr2

27545315

-SIGIRRchr11

406059

-


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Fusion Gene ORF analysis for MPV17-SIGIRR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000233545ENST00000431843MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000233545ENST00000397632MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000233545ENST00000332725MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000233545ENST00000531205MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000233545ENST00000382520MPV17chr2

27545315

-SIGIRRchr11

406059

-
5CDS-intronENST00000233545ENST00000529486MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000402310ENST00000431843MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000402310ENST00000397632MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000402310ENST00000332725MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000402310ENST00000531205MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000402310ENST00000382520MPV17chr2

27545315

-SIGIRRchr11

406059

-
5CDS-intronENST00000402310ENST00000529486MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000380044ENST00000431843MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000380044ENST00000397632MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000380044ENST00000332725MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000380044ENST00000531205MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000380044ENST00000382520MPV17chr2

27545315

-SIGIRRchr11

406059

-
5CDS-intronENST00000380044ENST00000529486MPV17chr2

27545315

-SIGIRRchr11

406059

-
intron-3CDSENST00000357186ENST00000431843MPV17chr2

27545315

-SIGIRRchr11

406059

-
intron-3CDSENST00000357186ENST00000397632MPV17chr2

27545315

-SIGIRRchr11

406059

-
intron-3CDSENST00000357186ENST00000332725MPV17chr2

27545315

-SIGIRRchr11

406059

-
intron-3CDSENST00000357186ENST00000531205MPV17chr2

27545315

-SIGIRRchr11

406059

-
intron-3CDSENST00000357186ENST00000382520MPV17chr2

27545315

-SIGIRRchr11

406059

-
intron-intronENST00000357186ENST00000529486MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000402722ENST00000431843MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000402722ENST00000397632MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000402722ENST00000332725MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000402722ENST00000531205MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000402722ENST00000382520MPV17chr2

27545315

-SIGIRRchr11

406059

-
5CDS-intronENST00000402722ENST00000529486MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000405983ENST00000431843MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000405983ENST00000397632MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000405983ENST00000332725MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000405983ENST00000531205MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000405983ENST00000382520MPV17chr2

27545315

-SIGIRRchr11

406059

-
5CDS-intronENST00000405983ENST00000529486MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000405076ENST00000431843MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000405076ENST00000397632MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000405076ENST00000332725MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000405076ENST00000531205MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000405076ENST00000382520MPV17chr2

27545315

-SIGIRRchr11

406059

-
5CDS-intronENST00000405076ENST00000529486MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000403262ENST00000431843MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000403262ENST00000397632MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000403262ENST00000332725MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000403262ENST00000531205MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000403262ENST00000382520MPV17chr2

27545315

-SIGIRRchr11

406059

-
5CDS-intronENST00000403262ENST00000529486MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000399052ENST00000431843MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000399052ENST00000397632MPV17chr2

27545315

-SIGIRRchr11

406059

-
In-frameENST00000399052ENST00000332725MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000399052ENST00000531205MPV17chr2

27545315

-SIGIRRchr11

406059

-
Frame-shiftENST00000399052ENST00000382520MPV17chr2

27545315

-SIGIRRchr11

406059

-
5CDS-intronENST00000399052ENST00000529486MPV17chr2

27545315

-SIGIRRchr11

406059

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000233545MPV17chr227545315-ENST00000431843SIGIRRchr11406059-461117114443109
ENST00000233545MPV17chr227545315-ENST00000397632SIGIRRchr11406059-461117114443109
ENST00000233545MPV17chr227545315-ENST00000332725SIGIRRchr11406059-461117114443109
ENST00000402310MPV17chr227545315-ENST00000431843SIGIRRchr11406059-4227875404109
ENST00000402310MPV17chr227545315-ENST00000397632SIGIRRchr11406059-4227875404109
ENST00000402310MPV17chr227545315-ENST00000332725SIGIRRchr11406059-4227875404109
ENST00000380044MPV17chr227545315-ENST00000431843SIGIRRchr11406059-470126123452109
ENST00000380044MPV17chr227545315-ENST00000397632SIGIRRchr11406059-470126123452109
ENST00000380044MPV17chr227545315-ENST00000332725SIGIRRchr11406059-470126123452109
ENST00000402722MPV17chr227545315-ENST00000431843SIGIRRchr11406059-449105102431109
ENST00000402722MPV17chr227545315-ENST00000397632SIGIRRchr11406059-449105102431109
ENST00000402722MPV17chr227545315-ENST00000332725SIGIRRchr11406059-449105102431109
ENST00000405983MPV17chr227545315-ENST00000431843SIGIRRchr11406059-4318784413109
ENST00000405983MPV17chr227545315-ENST00000397632SIGIRRchr11406059-4318784413109
ENST00000405983MPV17chr227545315-ENST00000332725SIGIRRchr11406059-4318784413109
ENST00000405076MPV17chr227545315-ENST00000431843SIGIRRchr11406059-470126123452109
ENST00000405076MPV17chr227545315-ENST00000397632SIGIRRchr11406059-470126123452109
ENST00000405076MPV17chr227545315-ENST00000332725SIGIRRchr11406059-470126123452109
ENST00000403262MPV17chr227545315-ENST00000431843SIGIRRchr11406059-4359188417109
ENST00000403262MPV17chr227545315-ENST00000397632SIGIRRchr11406059-4359188417109
ENST00000403262MPV17chr227545315-ENST00000332725SIGIRRchr11406059-4359188417109
ENST00000399052MPV17chr227545315-ENST00000431843SIGIRRchr11406059-465121118447109
ENST00000399052MPV17chr227545315-ENST00000397632SIGIRRchr11406059-465121118447109
ENST00000399052MPV17chr227545315-ENST00000332725SIGIRRchr11406059-465121118447109

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000233545ENST00000431843MPV17chr227545315-SIGIRRchr11406059-0.657004360.34299564
ENST00000233545ENST00000397632MPV17chr227545315-SIGIRRchr11406059-0.657004360.34299564
ENST00000233545ENST00000332725MPV17chr227545315-SIGIRRchr11406059-0.657004360.34299564
ENST00000402310ENST00000431843MPV17chr227545315-SIGIRRchr11406059-0.5883870.41161302
ENST00000402310ENST00000397632MPV17chr227545315-SIGIRRchr11406059-0.5883870.41161302
ENST00000402310ENST00000332725MPV17chr227545315-SIGIRRchr11406059-0.5883870.41161302
ENST00000380044ENST00000431843MPV17chr227545315-SIGIRRchr11406059-0.528529470.47147056
ENST00000380044ENST00000397632MPV17chr227545315-SIGIRRchr11406059-0.528529470.47147056
ENST00000380044ENST00000332725MPV17chr227545315-SIGIRRchr11406059-0.528529470.47147056
ENST00000402722ENST00000431843MPV17chr227545315-SIGIRRchr11406059-0.570090830.42990917
ENST00000402722ENST00000397632MPV17chr227545315-SIGIRRchr11406059-0.570090830.42990917
ENST00000402722ENST00000332725MPV17chr227545315-SIGIRRchr11406059-0.570090830.42990917
ENST00000405983ENST00000431843MPV17chr227545315-SIGIRRchr11406059-0.604169850.3958302
ENST00000405983ENST00000397632MPV17chr227545315-SIGIRRchr11406059-0.604169850.3958302
ENST00000405983ENST00000332725MPV17chr227545315-SIGIRRchr11406059-0.604169850.3958302
ENST00000405076ENST00000431843MPV17chr227545315-SIGIRRchr11406059-0.528529470.47147056
ENST00000405076ENST00000397632MPV17chr227545315-SIGIRRchr11406059-0.528529470.47147056
ENST00000405076ENST00000332725MPV17chr227545315-SIGIRRchr11406059-0.528529470.47147056
ENST00000403262ENST00000431843MPV17chr227545315-SIGIRRchr11406059-0.56312070.43687922
ENST00000403262ENST00000397632MPV17chr227545315-SIGIRRchr11406059-0.56312070.43687922
ENST00000403262ENST00000332725MPV17chr227545315-SIGIRRchr11406059-0.56312070.43687922
ENST00000399052ENST00000431843MPV17chr227545315-SIGIRRchr11406059-0.55266770.44733226
ENST00000399052ENST00000397632MPV17chr227545315-SIGIRRchr11406059-0.55266770.44733226
ENST00000399052ENST00000332725MPV17chr227545315-SIGIRRchr11406059-0.55266770.44733226

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Fusion Genomic Features for MPV17-SIGIRR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MPV17-SIGIRR


check button Go to

FGviewer for the breakpoints of chr2:27545315-chr11:406059

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPV17chr2:27545315chr11:406059ENST00000233545-17131_15123.333333333333332177.0TransmembraneHelical
HgeneMPV17chr2:27545315chr11:406059ENST00000233545-1718_3823.333333333333332177.0TransmembraneHelical
HgeneMPV17chr2:27545315chr11:406059ENST00000233545-1753_7323.333333333333332177.0TransmembraneHelical
HgeneMPV17chr2:27545315chr11:406059ENST00000233545-1794_11423.333333333333332177.0TransmembraneHelical
HgeneMPV17chr2:27545315chr11:406059ENST00000380044-28131_15123.333333333333332177.0TransmembraneHelical
HgeneMPV17chr2:27545315chr11:406059ENST00000380044-2818_3823.333333333333332177.0TransmembraneHelical
HgeneMPV17chr2:27545315chr11:406059ENST00000380044-2853_7323.333333333333332177.0TransmembraneHelical
HgeneMPV17chr2:27545315chr11:406059ENST00000380044-2894_11423.333333333333332177.0TransmembraneHelical
TgeneSIGIRRchr2:27545315chr11:406059ENST00000332725810163_307356.3333333333333411.0DomainTIR
TgeneSIGIRRchr2:27545315chr11:406059ENST000003327258109_109356.3333333333333411.0DomainNote=Ig-like C2-type
TgeneSIGIRRchr2:27545315chr11:406059ENST00000397632810163_307356.3333333333333411.0DomainTIR
TgeneSIGIRRchr2:27545315chr11:406059ENST000003976328109_109356.3333333333333411.0DomainNote=Ig-like C2-type
TgeneSIGIRRchr2:27545315chr11:406059ENST00000431843810163_307356.3333333333333411.0DomainTIR
TgeneSIGIRRchr2:27545315chr11:406059ENST000004318438109_109356.3333333333333411.0DomainNote=Ig-like C2-type
TgeneSIGIRRchr2:27545315chr11:406059ENST00000332725810140_410356.3333333333333411.0Topological domainCytoplasmic
TgeneSIGIRRchr2:27545315chr11:406059ENST000003327258101_118356.3333333333333411.0Topological domainExtracellular
TgeneSIGIRRchr2:27545315chr11:406059ENST00000397632810140_410356.3333333333333411.0Topological domainCytoplasmic
TgeneSIGIRRchr2:27545315chr11:406059ENST000003976328101_118356.3333333333333411.0Topological domainExtracellular
TgeneSIGIRRchr2:27545315chr11:406059ENST00000431843810140_410356.3333333333333411.0Topological domainCytoplasmic
TgeneSIGIRRchr2:27545315chr11:406059ENST000004318438101_118356.3333333333333411.0Topological domainExtracellular
TgeneSIGIRRchr2:27545315chr11:406059ENST00000332725810119_139356.3333333333333411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneSIGIRRchr2:27545315chr11:406059ENST00000397632810119_139356.3333333333333411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneSIGIRRchr2:27545315chr11:406059ENST00000431843810119_139356.3333333333333411.0TransmembraneHelical%3B Signal-anchor for type III membrane protein


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Fusion Gene Sequence for MPV17-SIGIRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000233545_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=461nt_BP=117nt
GAGGGACGGTGGGGGTGACCCCCTCTCCTCTTGGCTTGACAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACC
CGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGG
GAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGG
ATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACA
ACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAATAAAGTCCT

>In-frame_ENST00000233545_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=114_stop in transcript=443
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000233545_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=461nt_BP=117nt
GAGGGACGGTGGGGGTGACCCCCTCTCCTCTTGGCTTGACAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACC
CGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGG
GAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGG
ATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACA
ACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAATAAAGTCCT

>In-frame_ENST00000233545_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=114_stop in transcript=443
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000233545_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=461nt_BP=117nt
GAGGGACGGTGGGGGTGACCCCCTCTCCTCTTGGCTTGACAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACC
CGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGG
GAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGG
ATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACA
ACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAATAAAGTCCT

>In-frame_ENST00000233545_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=114_stop in transcript=443
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000402310_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=422nt_BP=78nt
CAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGC
CTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCG
GCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGG
GACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTG

>In-frame_ENST00000402310_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=75_stop in transcript=404
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000402310_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=422nt_BP=78nt
CAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGC
CTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCG
GCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGG
GACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTG

>In-frame_ENST00000402310_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=75_stop in transcript=404
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000402310_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=422nt_BP=78nt
CAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGC
CTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCG
GCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGG
GACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTG

>In-frame_ENST00000402310_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=75_stop in transcript=404
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000380044_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=470nt_BP=126nt
GCGGAAGTTCCTAGGCCAGCCTGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGG
CCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGG
TCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGG
TGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAAC
AGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAA

>In-frame_ENST00000380044_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=123_stop in transcript=452
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000380044_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=470nt_BP=126nt
GCGGAAGTTCCTAGGCCAGCCTGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGG
CCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGG
TCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGG
TGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAAC
AGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAA

>In-frame_ENST00000380044_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=123_stop in transcript=452
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000380044_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=470nt_BP=126nt
GCGGAAGTTCCTAGGCCAGCCTGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGG
CCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGG
TCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGG
TGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAAC
AGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAA

>In-frame_ENST00000380044_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=123_stop in transcript=452
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000402722_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=449nt_BP=105nt
TGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTAC
AGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGA
GCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGC
TCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGC

>In-frame_ENST00000402722_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=102_stop in transcript=431
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000402722_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=449nt_BP=105nt
TGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTAC
AGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGA
GCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGC
TCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGC

>In-frame_ENST00000402722_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=102_stop in transcript=431
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000402722_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=449nt_BP=105nt
TGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTAC
AGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGA
GCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGC
TCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGC

>In-frame_ENST00000402722_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=102_stop in transcript=431
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000405983_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=431nt_BP=87nt
CTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTG
TCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCT
CGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAG
GATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCA

>In-frame_ENST00000405983_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=84_stop in transcript=413
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000405983_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=431nt_BP=87nt
CTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTG
TCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCT
CGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAG
GATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCA

>In-frame_ENST00000405983_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=84_stop in transcript=413
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000405983_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=431nt_BP=87nt
CTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTG
TCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCT
CGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAG
GATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCA

>In-frame_ENST00000405983_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=84_stop in transcript=413
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000405076_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=470nt_BP=126nt
GCGGAAGTTCCTAGGCCAGCCTGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGG
CCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGG
TCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGG
TGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAAC
AGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAA

>In-frame_ENST00000405076_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=123_stop in transcript=452
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000405076_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=470nt_BP=126nt
GCGGAAGTTCCTAGGCCAGCCTGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGG
CCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGG
TCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGG
TGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAAC
AGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAA

>In-frame_ENST00000405076_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=123_stop in transcript=452
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000405076_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=470nt_BP=126nt
GCGGAAGTTCCTAGGCCAGCCTGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGG
CCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGG
TCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGG
TGTCCAAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAAC
AGGACCACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAA

>In-frame_ENST00000405076_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=123_stop in transcript=452
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000403262_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=435nt_BP=91nt
GAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCT
GGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGAC
GTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGCTCCCACCCCAGAGT
GCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGCAGCCCTGGGACCCT

>In-frame_ENST00000403262_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=88_stop in transcript=417
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000403262_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=435nt_BP=91nt
GAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCT
GGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGAC
GTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGCTCCCACCCCAGAGT
GCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGCAGCCCTGGGACCCT

>In-frame_ENST00000403262_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=88_stop in transcript=417
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000403262_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=435nt_BP=91nt
GAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCTCACCCGTGGAAAGTACAGGTCCTGACAGCT
GGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCGCTGGGAGAGAGCCGGAGCAGCGAAGTGGAC
GTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCCAAGGATGATATGTAGCTCCCACCCCAGAGT
GCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGACCACAACCCCTGCCAGCAGCCCTGGGACCCT

>In-frame_ENST00000403262_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=88_stop in transcript=417
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000399052_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=465nt_BP=121nt
AGTTCCTAGGCCAGCCTGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCT
CACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCG
CTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCC
AAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGAC
CACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAATAAAG

>In-frame_ENST00000399052_ENST00000431843_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=118_stop in transcript=447
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

--------------------------------------------------------------
>In-frame_ENST00000399052_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=465nt_BP=121nt
AGTTCCTAGGCCAGCCTGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCT
CACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCG
CTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCC
AAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGAC
CACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAATAAAG

>In-frame_ENST00000399052_ENST00000397632_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=118_stop in transcript=447
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

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>In-frame_ENST00000399052_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(transcript)=465nt_BP=121nt
AGTTCCTAGGCCAGCCTGTCACGTGGGAGGGAGGCTCGGCGCTCAGGAAGCATGGCACTCTGGCGGGCATACCAGCGGGCCCTGGCCGCT
CACCCGTGGAAAGTACAGGTCCTGACAGCTGGTGTCCGGGGGCCTGTCTTTGGAGAGCCATCAGCTCCACCGCACACCAGTGGGGTCTCG
CTGGGAGAGAGCCGGAGCAGCGAAGTGGACGTCTCGGATCTCGGCTCGCGAAACTACAGTGCCCGCACAGACTTCTACTGCCTGGTGTCC
AAGGATGATATGTAGCTCCCACCCCAGAGTGCAGGATCATAGGGACAGCGGGGGCCAGGGCAGCGGCGTCGCTCCTCTGCTCAACAGGAC
CACAACCCCTGCCAGCAGCCCTGGGACCCTGCCAGCAGCCCTGGGAAAAGGCTGTGGCCTCAGGGCGCCTCCCAGTGCCAGAAAATAAAG

>In-frame_ENST00000399052_ENST00000332725_TCGA-BR-A4QI-01A_MPV17_chr2_27545315_-_SIGIRR_chr11_406059_length(amino acids)=109AA_start in transcript=118_stop in transcript=447
MVSGGLSLESHQLHRTPVGSRWERAGAAKWTSRISARETTVPAQTSTAWCPRMICSSHPRVQDHRDSGGQGSGVAPLLNRTTTPASSPGT

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Fusion Gene PPI Analysis for MPV17-SIGIRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MPV17-SIGIRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MPV17-SIGIRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPV17C1850406NAVAJO NEUROHEPATOPATHY18CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneMPV17C0008370Cholestasis1GENOMICS_ENGLAND
HgeneMPV17C0009197Cochlear Diseases1CTD_human
HgeneMPV17C0017668Focal glomerulosclerosis1CTD_human
HgeneMPV17C0022283Incontinentia Pigmenti Achromians1CTD_human
HgeneMPV17C0033687Proteinuria1CTD_human
HgeneMPV17C0036305Schamberg Disease1CTD_human
HgeneMPV17C0085605Liver Failure1GENOMICS_ENGLAND
HgeneMPV17C0086432Hyalinosis, Segmental Glomerular1CTD_human
HgeneMPV17C0344307Absence of pain sensation1GENOMICS_ENGLAND
HgeneMPV17C0549567Pigmentation Disorders1CTD_human
HgeneMPV17C0751651Mitochondrial Diseases1CTD_human
HgeneMPV17C0949855Electron Transport Chain Deficiencies, Mitochondrial1CTD_human
HgeneMPV17C0949856Oxidative Phosphorylation Deficiencies1CTD_human
HgeneMPV17C0949857Mitochondrial Respiratory Chain Deficiencies1CTD_human