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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MRE11A-YAP1 (FusionGDB2 ID:54515)

Fusion Gene Summary for MRE11A-YAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: MRE11A-YAP1
Fusion gene ID: 54515
HgeneTgene
Gene symbol

MRE11A

YAP1

Gene ID

4361

10413

Gene nameMRE11 homolog, double strand break repair nucleaseYes1 associated transcriptional regulator
SynonymsATLD|HNGS1|MRE11A|MRE11BCOB1|YAP|YAP2|YAP65|YKI
Cytomap

11q21

11q22.1

Type of geneprotein-codingprotein-coding
Descriptiondouble-strand break repair protein MRE11AT-like diseaseDNA recombination and repair proteinMRE11 double strand break repair nuclease AMRE11 homolog 1MRE11 homolog A, double strand break repair nucleaseMRE11 homolog, double strand break repair nucleatranscriptional coactivator YAP165 kDa Yes-associated proteinYes associated protein 1protein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog
Modification date2020031520200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000323929, ENST00000407439, 
ENST00000323977, ENST00000393241, 
ENST00000540013, ENST00000536144, 
ENST00000526343, ENST00000282441, 
ENST00000537274, ENST00000345877, 
ENST00000531439, ENST00000524575, 
ENST00000528834, 
Fusion gene scores* DoF score5 X 6 X 3=9020 X 10 X 13=2600
# samples 621
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2600*10)=-3.63005039024969
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRE11A [Title/Abstract] AND YAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMRE11A(94163077)-YAP1(102033187), # samples:1
Anticipated loss of major functional domain due to fusion event.MRE11A-YAP1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
MRE11A-YAP1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMRE11A

GO:0000724

double-strand break repair via homologous recombination

29670289|30612738

HgeneMRE11A

GO:0006303

double-strand break repair via nonhomologous end joining

9651580

HgeneMRE11A

GO:0006974

cellular response to DNA damage stimulus

17500065|29670289

HgeneMRE11A

GO:0031954

positive regulation of protein autophosphorylation

15790808

HgeneMRE11A

GO:0033674

positive regulation of kinase activity

15790808

HgeneMRE11A

GO:0110025

DNA strand resection involved in replication fork processing

29670289

TgeneYAP1

GO:0006974

cellular response to DNA damage stimulus

18280240

TgeneYAP1

GO:0008283

cell proliferation

17974916

TgeneYAP1

GO:0032570

response to progesterone

16772533

TgeneYAP1

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

16772533

TgeneYAP1

GO:0045893

positive regulation of transcription, DNA-templated

20368466

TgeneYAP1

GO:0045944

positive regulation of transcription by RNA polymerase II

25796446

TgeneYAP1

GO:0050767

regulation of neurogenesis

25433207

TgeneYAP1

GO:0050847

progesterone receptor signaling pathway

16772533

TgeneYAP1

GO:0060242

contact inhibition

17974916

TgeneYAP1

GO:0065003

protein-containing complex assembly

20368466

TgeneYAP1

GO:0071480

cellular response to gamma radiation

18280240

TgeneYAP1

GO:0072091

regulation of stem cell proliferation

25433207


check buttonFusion gene breakpoints across MRE11A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across YAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-5855-01AMRE11Achr11

94163077

-YAP1chr11

102033187

+


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Fusion Gene ORF analysis for MRE11A-YAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000323929ENST00000526343MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000323929ENST00000282441MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000323929ENST00000537274MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000323929ENST00000345877MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000323929ENST00000531439MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000323929ENST00000524575MRE11Achr11

94163077

-YAP1chr11

102033187

+
5CDS-intronENST00000323929ENST00000528834MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000407439ENST00000526343MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000407439ENST00000282441MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000407439ENST00000537274MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000407439ENST00000345877MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000407439ENST00000531439MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000407439ENST00000524575MRE11Achr11

94163077

-YAP1chr11

102033187

+
5CDS-intronENST00000407439ENST00000528834MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000323977ENST00000526343MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000323977ENST00000282441MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000323977ENST00000537274MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000323977ENST00000345877MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000323977ENST00000531439MRE11Achr11

94163077

-YAP1chr11

102033187

+
Frame-shiftENST00000323977ENST00000524575MRE11Achr11

94163077

-YAP1chr11

102033187

+
5CDS-intronENST00000323977ENST00000528834MRE11Achr11

94163077

-YAP1chr11

102033187

+
In-frameENST00000393241ENST00000526343MRE11Achr11

94163077

-YAP1chr11

102033187

+
In-frameENST00000393241ENST00000282441MRE11Achr11

94163077

-YAP1chr11

102033187

+
In-frameENST00000393241ENST00000537274MRE11Achr11

94163077

-YAP1chr11

102033187

+
In-frameENST00000393241ENST00000345877MRE11Achr11

94163077

-YAP1chr11

102033187

+
In-frameENST00000393241ENST00000531439MRE11Achr11

94163077

-YAP1chr11

102033187

+
In-frameENST00000393241ENST00000524575MRE11Achr11

94163077

-YAP1chr11

102033187

+
5CDS-intronENST00000393241ENST00000528834MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000540013ENST00000526343MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000540013ENST00000282441MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000540013ENST00000537274MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000540013ENST00000345877MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000540013ENST00000531439MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000540013ENST00000524575MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-intronENST00000540013ENST00000528834MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000536144ENST00000526343MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000536144ENST00000282441MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000536144ENST00000537274MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000536144ENST00000345877MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000536144ENST00000531439MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-3CDSENST00000536144ENST00000524575MRE11Achr11

94163077

-YAP1chr11

102033187

+
intron-intronENST00000536144ENST00000528834MRE11Achr11

94163077

-YAP1chr11

102033187

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393241MRE11Achr1194163077-ENST00000526343YAP1chr11102033187+373323002212614797
ENST00000393241MRE11Achr1194163077-ENST00000282441YAP1chr11102033187+672623002212428735
ENST00000393241MRE11Achr1194163077-ENST00000537274YAP1chr11102033187+669023002212428735
ENST00000393241MRE11Achr1194163077-ENST00000345877YAP1chr11102033187+657623002212626801
ENST00000393241MRE11Achr1194163077-ENST00000531439YAP1chr11102033187+321823002212428735
ENST00000393241MRE11Achr1194163077-ENST00000524575YAP1chr11102033187+345523002212428735

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393241ENST00000526343MRE11Achr1194163077-YAP1chr11102033187+0.0011602460.9988398
ENST00000393241ENST00000282441MRE11Achr1194163077-YAP1chr11102033187+0.0001515860.99984837
ENST00000393241ENST00000537274MRE11Achr1194163077-YAP1chr11102033187+0.00014730.99985266
ENST00000393241ENST00000345877MRE11Achr1194163077-YAP1chr11102033187+0.000126370.99987364
ENST00000393241ENST00000531439MRE11Achr1194163077-YAP1chr11102033187+0.0033438570.9966562
ENST00000393241ENST00000524575MRE11Achr1194163077-YAP1chr11102033187+0.0029628120.9970372

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Fusion Genomic Features for MRE11A-YAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MRE11A-YAP1


check button Go to

FGviewer for the breakpoints of chr11:94163077-chr11:102033187

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneYAP1chr11:94163077chr11:102033187ENST0000028244119298_359190.66666666666666505.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:94163077chr11:102033187ENST0000034587717298_359190.66666666666666455.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:94163077chr11:102033187ENST0000052457519298_35912.666666666666666327.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:94163077chr11:102033187ENST000005245751986_10012.666666666666666327.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:94163077chr11:102033187ENST0000052634317298_359190.66666666666666451.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:94163077chr11:102033187ENST0000053143918298_359190.66666666666666489.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:94163077chr11:102033187ENST0000053727418298_359190.66666666666666493.0Coiled coilOntology_term=ECO:0000255
TgeneYAP1chr11:94163077chr11:102033187ENST0000028244119230_263190.66666666666666505.0DomainWW 2
TgeneYAP1chr11:94163077chr11:102033187ENST0000034587717230_263190.66666666666666455.0DomainWW 2
TgeneYAP1chr11:94163077chr11:102033187ENST0000052457519171_20412.666666666666666327.0DomainWW 1
TgeneYAP1chr11:94163077chr11:102033187ENST0000052457519230_26312.666666666666666327.0DomainWW 2
TgeneYAP1chr11:94163077chr11:102033187ENST0000052634317230_263190.66666666666666451.0DomainWW 2
TgeneYAP1chr11:94163077chr11:102033187ENST0000053143918230_263190.66666666666666489.0DomainWW 2
TgeneYAP1chr11:94163077chr11:102033187ENST0000053727418230_263190.66666666666666493.0DomainWW 2
TgeneYAP1chr11:94163077chr11:102033187ENST0000028244119291_504190.66666666666666505.0RegionNote=Transactivation domain
TgeneYAP1chr11:94163077chr11:102033187ENST0000034587717291_504190.66666666666666455.0RegionNote=Transactivation domain
TgeneYAP1chr11:94163077chr11:102033187ENST0000052457519291_50412.666666666666666327.0RegionNote=Transactivation domain
TgeneYAP1chr11:94163077chr11:102033187ENST0000052634317291_504190.66666666666666451.0RegionNote=Transactivation domain
TgeneYAP1chr11:94163077chr11:102033187ENST0000053143918291_504190.66666666666666489.0RegionNote=Transactivation domain
TgeneYAP1chr11:94163077chr11:102033187ENST0000053727418291_504190.66666666666666493.0RegionNote=Transactivation domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneYAP1chr11:94163077chr11:102033187ENST000002824411986_100190.66666666666666505.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:94163077chr11:102033187ENST000003458771786_100190.66666666666666455.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:94163077chr11:102033187ENST000005263431786_100190.66666666666666451.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:94163077chr11:102033187ENST000005314391886_100190.66666666666666489.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:94163077chr11:102033187ENST000005372741886_100190.66666666666666493.0Coiled coilOntology_term=ECO:0000269
TgeneYAP1chr11:94163077chr11:102033187ENST00000282441193_49190.66666666666666505.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:94163077chr11:102033187ENST00000345877173_49190.66666666666666455.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:94163077chr11:102033187ENST00000524575193_4912.666666666666666327.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:94163077chr11:102033187ENST00000526343173_49190.66666666666666451.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:94163077chr11:102033187ENST00000531439183_49190.66666666666666489.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:94163077chr11:102033187ENST00000537274183_49190.66666666666666493.0Compositional biasNote=Pro-rich
TgeneYAP1chr11:94163077chr11:102033187ENST0000028244119171_204190.66666666666666505.0DomainWW 1
TgeneYAP1chr11:94163077chr11:102033187ENST0000034587717171_204190.66666666666666455.0DomainWW 1
TgeneYAP1chr11:94163077chr11:102033187ENST0000052634317171_204190.66666666666666451.0DomainWW 1
TgeneYAP1chr11:94163077chr11:102033187ENST0000053143918171_204190.66666666666666489.0DomainWW 1
TgeneYAP1chr11:94163077chr11:102033187ENST0000053727418171_204190.66666666666666493.0DomainWW 1


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Fusion Gene Sequence for MRE11A-YAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000393241_ENST00000526343_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(transcript)=3733nt_BP=2300nt
AAACGGACGCCGTTCTCTCCCGCGGAATTCAGGTTTACGGCCCTGCGGGTTCTCAGAGGCAAGTTCAGACCGTGTTGTTTTCTTTTCACG
GATCCTGCCCTTTCTTCCCGAAAAGAAGACAGCCTTGGAATTTCTAGAATTTGGAATCGAGTGCATTTTCTGACATTTGAGTACAGTACC
CAGGGGTTCTTGGAGAAGAACCTGGTCCCAGAGGAGCTTGACTGACCATAAAAATGAGTACTGCAGATGCACTTGATGATGAAAACACAT
TTAAAATATTAGTTGCAACAGATATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGATACGTTTGTAACACTCGATGAAA
TTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTTTTTCATGAAAATAAGCCCTCAAGGAAAACATTAC
ATACCTGCCTCGAGTTATTAAGAAAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTGATCAGTCAGTCAACTTTGGTT
TTAGTAAGTTTCCATGGGTGAACTATCAAGATGGCAACCTCAACATTTCAATTCCAGTGTTTAGTATTCATGGCAATCATGACGATCCCA
CAGGGGCAGATGCACTTTGTGCCTTGGACATTTTAAGTTGTGCTGGATTTGTAAATCACTTTGGACGTTCAATGTCTGTGGAGAAGATAG
ACATTAGTCCGGTTTTGCTTCAAAAAGGAAGCACAAAGATTGCGCTATATGGTTTAGGATCCATTCCAGATGAAAGGCTCTATCGAATGT
TTGTCAATAAAAAAGTAACAATGTTGAGACCAAAGGAAGATGAGAACTCTTGGTTTAACTTATTTGTGATTCATCAGAACAGGAGTAAAC
ATGGAAGTACTAACTTCATTCCAGAACAATTTTTGGATGACTTCATTGATCTTGTTATCTGGGGCCATGAACATGAGTGTAAAATAGCTC
CAACCAAAAATGAACAACAGCTGTTTTATATCTCACAACCTGGAAGCTCAGTGGTTACTTCTCTTTCCCCAGGAGAAGCTGTAAAGAAAC
ATGTTGGTTTGCTGCGTATTAAAGGGAGGAAGATGAATATGCATAAAATTCCTCTTCACACAGTGCGGCAGTTTTTCATGGAGGATATTG
TTCTAGCTAATCATCCAGACATTTTTAACCCAGATAATCCTAAAGTAACCCAAGCCATACAAAGCTTCTGTTTGGAGAAGATTGAAGAAA
TGCTTGAAAATGCTGAACGGGAACGTCTGGGTAATTCTCACCAGCCAGAGAAGCCTCTTGTACGACTGCGAGTGGACTATAGTGGAGGTT
TTGAACCTTTCAGTGTTCTTCGCTTTAGCCAGAAATTTGTGGATCGGGTAGCTAATCCAAAAGACATTATCCATTTTTTCAGGCATAGAG
AACAAAAGGAAAAAACAGGAGAAGAGATCAACTTTGGGAAACTTATCACAAAGCCTTCAGAAGGAACAACTTTAAGGGTAGAAGATCTTG
TAAAACAGTACTTTCAAACCGCAGAGAAGAATGTGCAGCTCTCACTGCTAACAGAAAGAGGGATGGGTGAAGCAGTACAAGAATTTGTGG
ACAAGGAGGAGAAAGATGCCATTGAGGAATTAGTGAAATACCAGTTGGAAAAAACACAGCGATTTCTTAAAGAACGTCATATTGATGCCC
TCGAAGACAAAATCGATGAGGAGGTACGTCGTTTCAGAGAAACCAGACAAAAAAATACTAATGAAGAAGATGATGAAGTCCGTGAGGCTA
TGACCAGGGCCAGAGCACTCAGATCTCAGTCAGAGGAGTCTGCTTCTGCCTTTAGTGCTGATGACCTTATGAGTATAGATTTAGCAGAAC
AGATGGCTAATGACTCTGATGATAGCATCTCAGCAGCAACCAACAAAGGAAGAGGCCGAGGAAGAGGTCGAAGAGGTGGAAGAGGGCAGA
ATTCAGCATCGAGAGGAGGGTCTCAAAGAGGAAGAGACACTGGTCTGGAGACTTCTACCCGTAGCAGGAACTCAAAGACTGCTGTGTCAG
CATCTAGAAATATGTCTATTATAGATGCCTTTAAATCTACAAGACAGCAGCCTTCCCGAAATGTCACTACTAAGAATTATTCAGAGGTGA
TTGAGGTAGATGAATCAGATGTGGAAGAAGACATTTTTCCTACCACTTCAAAGACAGATCAAAGGTGGTCCAGCACATCATCCAGCAAAA
TCATGTCCCAGAGTCAAGTATCGAAAGGGGTTGATTTTGAATCAAGTGAGTCACATCGATCAGACAACAACATGGCAGGACCCCAGGAAG
GCCATGCTGTCCCAGATGAACGTCACAGCCCCCACCAGTCCACCAGTGCAGCAGAATATGATGAACTCGGCTTCAGCCATGAACCAGAGA
ATCAGTCAGAGTGCTCCAGTGAAACAGCCACCACCCCTGGCTCCCCAGAGCCCACAGGGAGGCGTCATGGGTGGCAGCAACTCCAACCAG
CAGCAACAGATGCGACTGCAGCAACTGCAGATGGAGAAGGAGAGGCTGCGGCTGAAACAGCAAGAACTGCTTCGGCAGGAGTTAGCCCTG
CGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACG
ACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGT
GTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAG
AACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAG
GAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCTTAATGACATGGAGTCTGTTTTGGCTGCCACCAAGCTAGATAAAGAA
AGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCTAAATCTGTGAAGGATCTAAGGAGACACATGCACCGGAAATTTCCAT
AAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAAACGTCCAGCAAGATACTTTAATCCTCTATTTTGCTCTTCCTTGTCC
ATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTCTAAAGAATCAAAAGAAAAAAACTTTTTATTTCTTTTGCTATTAAAA
CTACTGTTCATTTTGGGGGCTGGGGGAAGTGAGCCTGTTTGGATGATGGATGCCATTCCTTTTGCCCAGTTAAATGTTCACCAATCATTT
TAACTAAATACTCAGACTTAGAAGTCAGATGCTTCATGTCACAGCATTTAGTTTGTTCAACAGTTGTTTCTTCAGCTTCCTTTGTCCAGT
GGAAAAACATGATTTACTGGTCTGACAAGCCAAAAATGTTATATCTGATATTAAATACTTAATGCTGATTTGAAGAGATAGCTGAAACCA
AGGCTGAAGACTGTTTTACTTTCAGTATTTTCTTTTCCTCCTAGTGCTATCATTAGTCACATAATGACCTTGATTTTATTTTAGGAGCTT

>In-frame_ENST00000393241_ENST00000526343_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(amino acids)=797AA_start in transcript=221_stop in transcript=2614
MTIKMSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGD
RPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKI
ALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQP
GSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSH
QPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQL
SLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEES
ASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRDTGLETSTRSRNSKTAVSASRNMSIIDAFKST
RQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSESHRSDNNMAGPQEGHAVPDERHSPHQS

--------------------------------------------------------------
>In-frame_ENST00000393241_ENST00000282441_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(transcript)=6726nt_BP=2300nt
AAACGGACGCCGTTCTCTCCCGCGGAATTCAGGTTTACGGCCCTGCGGGTTCTCAGAGGCAAGTTCAGACCGTGTTGTTTTCTTTTCACG
GATCCTGCCCTTTCTTCCCGAAAAGAAGACAGCCTTGGAATTTCTAGAATTTGGAATCGAGTGCATTTTCTGACATTTGAGTACAGTACC
CAGGGGTTCTTGGAGAAGAACCTGGTCCCAGAGGAGCTTGACTGACCATAAAAATGAGTACTGCAGATGCACTTGATGATGAAAACACAT
TTAAAATATTAGTTGCAACAGATATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGATACGTTTGTAACACTCGATGAAA
TTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTTTTTCATGAAAATAAGCCCTCAAGGAAAACATTAC
ATACCTGCCTCGAGTTATTAAGAAAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTGATCAGTCAGTCAACTTTGGTT
TTAGTAAGTTTCCATGGGTGAACTATCAAGATGGCAACCTCAACATTTCAATTCCAGTGTTTAGTATTCATGGCAATCATGACGATCCCA
CAGGGGCAGATGCACTTTGTGCCTTGGACATTTTAAGTTGTGCTGGATTTGTAAATCACTTTGGACGTTCAATGTCTGTGGAGAAGATAG
ACATTAGTCCGGTTTTGCTTCAAAAAGGAAGCACAAAGATTGCGCTATATGGTTTAGGATCCATTCCAGATGAAAGGCTCTATCGAATGT
TTGTCAATAAAAAAGTAACAATGTTGAGACCAAAGGAAGATGAGAACTCTTGGTTTAACTTATTTGTGATTCATCAGAACAGGAGTAAAC
ATGGAAGTACTAACTTCATTCCAGAACAATTTTTGGATGACTTCATTGATCTTGTTATCTGGGGCCATGAACATGAGTGTAAAATAGCTC
CAACCAAAAATGAACAACAGCTGTTTTATATCTCACAACCTGGAAGCTCAGTGGTTACTTCTCTTTCCCCAGGAGAAGCTGTAAAGAAAC
ATGTTGGTTTGCTGCGTATTAAAGGGAGGAAGATGAATATGCATAAAATTCCTCTTCACACAGTGCGGCAGTTTTTCATGGAGGATATTG
TTCTAGCTAATCATCCAGACATTTTTAACCCAGATAATCCTAAAGTAACCCAAGCCATACAAAGCTTCTGTTTGGAGAAGATTGAAGAAA
TGCTTGAAAATGCTGAACGGGAACGTCTGGGTAATTCTCACCAGCCAGAGAAGCCTCTTGTACGACTGCGAGTGGACTATAGTGGAGGTT
TTGAACCTTTCAGTGTTCTTCGCTTTAGCCAGAAATTTGTGGATCGGGTAGCTAATCCAAAAGACATTATCCATTTTTTCAGGCATAGAG
AACAAAAGGAAAAAACAGGAGAAGAGATCAACTTTGGGAAACTTATCACAAAGCCTTCAGAAGGAACAACTTTAAGGGTAGAAGATCTTG
TAAAACAGTACTTTCAAACCGCAGAGAAGAATGTGCAGCTCTCACTGCTAACAGAAAGAGGGATGGGTGAAGCAGTACAAGAATTTGTGG
ACAAGGAGGAGAAAGATGCCATTGAGGAATTAGTGAAATACCAGTTGGAAAAAACACAGCGATTTCTTAAAGAACGTCATATTGATGCCC
TCGAAGACAAAATCGATGAGGAGGTACGTCGTTTCAGAGAAACCAGACAAAAAAATACTAATGAAGAAGATGATGAAGTCCGTGAGGCTA
TGACCAGGGCCAGAGCACTCAGATCTCAGTCAGAGGAGTCTGCTTCTGCCTTTAGTGCTGATGACCTTATGAGTATAGATTTAGCAGAAC
AGATGGCTAATGACTCTGATGATAGCATCTCAGCAGCAACCAACAAAGGAAGAGGCCGAGGAAGAGGTCGAAGAGGTGGAAGAGGGCAGA
ATTCAGCATCGAGAGGAGGGTCTCAAAGAGGAAGAGACACTGGTCTGGAGACTTCTACCCGTAGCAGGAACTCAAAGACTGCTGTGTCAG
CATCTAGAAATATGTCTATTATAGATGCCTTTAAATCTACAAGACAGCAGCCTTCCCGAAATGTCACTACTAAGAATTATTCAGAGGTGA
TTGAGGTAGATGAATCAGATGTGGAAGAAGACATTTTTCCTACCACTTCAAAGACAGATCAAAGGTGGTCCAGCACATCATCCAGCAAAA
TCATGTCCCAGAGTCAAGTATCGAAAGGGGTTGATTTTGAATCAAGTGAGTCACATCGATCAGACAACAACATGGCAGGACCCCAGGAAG
GCCATGCTGTCCCAGATGAACGTCACAGCCCCCACCAGTCCACCAGTGCAGCAGAATATGATGAACTCGGCTTCAGGTCCTCTTCCTGAT
GGATGGGAACAAGCCATGACTCAGGATGGAGAAATTTACTATATAAACCATAAGAACAAGACCACCTCTTGGCTAGACCCAAGGCTTGAC
CCTCGTTTTGCCATGAACCAGAGAATCAGTCAGAGTGCTCCAGTGAAACAGCCACCACCCCTGGCTCCCCAGAGCCCACAGGGAGGCGTC
ATGGGTGGCAGCAACTCCAACCAGCAGCAACAGATGCGACTGCAGCAACTGCAGATGGAGAAGGAGAGGCTGCGGCTGAAACAGCAAGAA
CTGCTTCGGCAGGCAATGCGGAATATCAATCCCAGCACAGCAAATTCTCCAAAATGTCAGGAGTTAGCCCTGCGTAGCCAGTTACCAACA
CTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCT
TTCCTTAACAGTGGCACCTATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGAT
GACTTCCTGAACAGTGTGGATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTAC
CTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTG
CAGGAAGCTTTGAGTTCTGACATCCTTAATGACATGGAGTCTGTTTTGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTA
TAGAGCCCTCAGGCAGACTGAATTCTAAATCTGTGAAGGATCTAAGGAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTC
AGGCTAATACAGAAAAAGATGAACAAACGTCCAGCAAGATACTTTAATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTA
TTGCTGACCTCTTTCACAGTTGGCTCTAAAGAATCAAAAGAAAAAAACTTTTTATTTCTTTTGCTATTAAAACTACTGTTCATTTTGGGG
GCTGGGGGAAGTGAGCCTGTTTGGATGATGGATGCCATTCCTTTTGCCCAGTTAAATGTTCACCAATCATTTTAACTAAATACTCAGACT
TAGAAGTCAGATGCTTCATGTCACAGCATTTAGTTTGTTCAACAGTTGTTTCTTCAGCTTCCTTTGTCCAGTGGAAAAACATGATTTACT
GGTCTGACAAGCCAAAAATGTTATATCTGATATTAAATACTTAATGCTGATTTGAAGAGATAGCTGAAACCAAGGCTGAAGACTGTTTTA
CTTTCAGTATTTTCTTTTCCTCCTAGTGCTATCATTAGTCACATAATGACCTTGATTTTATTTTAGGAGCTTATAAGGCATGAGACAATT
TCCATATAAATATATTAATTATTGCCACATACTCTAATATAGATTTTGGTGGATAATTTTGTGGGTGTGCATTTTGTTCTGTTTTGTTGG
GTTTTTTGTTTTTTTTGTTTTTGGCAGGGTCGGTGGGGGGGTTGGTTGGTTGGTTGGTTTTGTCGGAACCTAGGCAAATGACCATATTAG
TGAATCTGTTAATAGTTGTAGCTTGGGATGGTTATTGTAGTTGTTTTGGTAAAATCTTCATTTCCTGGTTTTTTTTACCACCTTATTTAA
ATCTCGATTATCTGCTCTCTCTTTTATATACATACACACACCCAAACATAACATTTATAATAGTGTGGTAGTGGAATGTATCCTTTTTTA
GGTTTCCCTGCTTTCCAGTTAATTTTTAAAATGGTAGCGCTTTGTATGCATTTAGAATACATGACTAGTAGTTTATATTTCACTGGTAGT
TTAAATCTGGTTGGGGCAGTCTGCAGATGTTTGAAGTAGTTTAGTGTTCTAGAAAGAGCTATTACTGTGGATAGTGCCTAGGGGAGTGCT
CCACGCCCTCTGGGCATACGGTAGATATTATCTGATGAATTGGAAAGGAGCAAACCAGAAATGGCTTTATTTTCTCCCTTGGACTAATTT
TTAAGTCTCGATTGGAATTCAGTGAGTAGGTTCATAATGTGCATGACAGAAATAAGCTTTATAGTGGTTTACCTTCATTTAGCTTTGGAA
GTTTTCTTTGCCTTAGTTTTGGAAGTAAATTCTAGTTTGTAGTTCTCATTTGTAATGAACACATTAACGACTAGATTAAAATATTGCCTT
CAAGATTGTTCTTACTTACAAGACTTGCTCCTACTTCTATGCTGAAAATTGACCCTGGATAGAATACTATAAGGTTTTGAGTTAGCTGGA
AAAGTGATCAGATTAATAAATGTATATTGGTAGTTGAATTTAGCAAAGAAATAGAGATAATCATGATTATACCTTTATTTTTACAGGAAG
AGATGATGTAACTAGAGTATGTGTCTACAGGAGTAATAATGGTTTCCAAAGAGTATTTTTTAAAGGAACAAAACGAGCATGAATTAACTC
TTCAATATAAGCTATGAAGTAATAGTTGGTTGTGAATTAAAGTGGCACCAGCTAGCACCTCTGTGTTTTAAGGGTCTTTCAATGTTTCTA
GAATAAGCCCTTATTTTCAAGGGTTCATAACAGGCATAAAATCTCTTCTCCTGGCAAAAGCTGCTATGAAAAGCCTCAGCTTGGGAAGAT
AGATTTTTTTCCCCCCAATTACAAAATCTAAGTATTTTGGCCCTTCAATTTGGAGGAGGGCAAAAGTTGGAAGTAAGAAGTTTTATTTTA
AGTACTTTCAGTGCTCAAAAAAATGCAATCACTGTGTTGTATATAATAGTTCATAGGTTGATCACTCATAATAATTGACTCTAAGGCTTT
TATTAAGAAAACAGCAGAAAGATTAAATCTTGAATTAAGTCTGGGGGGAAATGGCCACTGCAGATGGAGTTTTAGAGTAGTAATGAAATT
CTACCTAGAATGCAAAATTGGGTATATGAATTACATAGCATGTTGTTGGGATTTTTTTTAATGTGCAGAAGATCAAAGCTACTTGGAAGG
AGTGCCTATAATTTGCCAGTAGCCACAGATTAAGATTATATCTTATATATCAGCAGATTAGCTTTAGCTTAGGGGGAGGGTGGGAAAGTT
TGGGGGGGGGGTTGTGAAGATTTAGGGGGACCTTGATAGAGAACTTTATAAACTTCTTTCTCTTTAATAAAGACTTGTCTTACACCGTGC
TGCCATTAAAGGCAGCTGTTCTAGAGTTTCAGTCACCTAAGTACACCCACAAAACAATATGAATATGGAGATCTTCCTTTACCCCTCAAC
TTTAATTTGCCCAGTTATACCTCAGTGTTGTAGCAGTACTGTGATACCTGGCACAGTGCTTTGATCTTACGATGCCCTCTGTACTGACCT
GAAGGAGACCTAAGAGTCCTTTCCCTTTTTGAGTTTGAATCATAGCCTTGATGTGGTCTCTTGTTTTATGTCCTTGTTCCTAATGTAAAA
GTGCTTAACTGCTTCTTGGTTGTATTGGGTAGCATTGGGATAAGATTTTAACTGGGTATTCTTGAATTGCTTTTACAATAAACCAATTTT
ATAATCTTTAAATTTATCAACTTTTTACATTTGTGTTATTTTCAGTCAGGGCTTCTTAGATCTACTTATGGTTGATGGAGCACATTGATT
TGGAGTTTCAGATCTTCCAAAGCACTATTTGTTGTAATAACTTTTCTAAATGTAGTGCCTTTAAAGGAAAAATGAACACAGGGAAGTGAC
TTTGCTACAAATAATGTTGCTGTGTTAAGTATTCATATTAAATACATGCCTTCTATATGGAACATGGCAGAAAGACTGAAAAATAACAGT
AATTAATTGTGTAATTCAGAATTCATACCAATCAGTGTTGAAACTCAAACATTGCAAAAGTGGGTGGCAATATTCAGTGCTTAACACTTT
TCTAGCGTTGGTACATCTGAGAAATGAGTGCTCAGGTGGATTTTATCCTCGCAAGCATGTTGTTATAAGAATTGTGGGTGTGCCTATCAT
AACAATTGTTTTCTGTATCTTGAAAAAGTATTCTCCACATTTTAAATGTTTTATATTAGAGAATTCTTTAATGCACACTTGTCAAATATA
TATATATAGTACCAATGTTACCTTTTTATTTTTTGTTTTAGATGTAAGAGCATGCTCATATGTTAGGTACTTACATAAATTGTTACATTA

>In-frame_ENST00000393241_ENST00000282441_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(amino acids)=735AA_start in transcript=221_stop in transcript=2428
MTIKMSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGD
RPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKI
ALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQP
GSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSH
QPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQL
SLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEES
ASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRDTGLETSTRSRNSKTAVSASRNMSIIDAFKST
RQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSESHRSDNNMAGPQEGHAVPDERHSPHQS

--------------------------------------------------------------
>In-frame_ENST00000393241_ENST00000537274_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(transcript)=6690nt_BP=2300nt
AAACGGACGCCGTTCTCTCCCGCGGAATTCAGGTTTACGGCCCTGCGGGTTCTCAGAGGCAAGTTCAGACCGTGTTGTTTTCTTTTCACG
GATCCTGCCCTTTCTTCCCGAAAAGAAGACAGCCTTGGAATTTCTAGAATTTGGAATCGAGTGCATTTTCTGACATTTGAGTACAGTACC
CAGGGGTTCTTGGAGAAGAACCTGGTCCCAGAGGAGCTTGACTGACCATAAAAATGAGTACTGCAGATGCACTTGATGATGAAAACACAT
TTAAAATATTAGTTGCAACAGATATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGATACGTTTGTAACACTCGATGAAA
TTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTTTTTCATGAAAATAAGCCCTCAAGGAAAACATTAC
ATACCTGCCTCGAGTTATTAAGAAAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTGATCAGTCAGTCAACTTTGGTT
TTAGTAAGTTTCCATGGGTGAACTATCAAGATGGCAACCTCAACATTTCAATTCCAGTGTTTAGTATTCATGGCAATCATGACGATCCCA
CAGGGGCAGATGCACTTTGTGCCTTGGACATTTTAAGTTGTGCTGGATTTGTAAATCACTTTGGACGTTCAATGTCTGTGGAGAAGATAG
ACATTAGTCCGGTTTTGCTTCAAAAAGGAAGCACAAAGATTGCGCTATATGGTTTAGGATCCATTCCAGATGAAAGGCTCTATCGAATGT
TTGTCAATAAAAAAGTAACAATGTTGAGACCAAAGGAAGATGAGAACTCTTGGTTTAACTTATTTGTGATTCATCAGAACAGGAGTAAAC
ATGGAAGTACTAACTTCATTCCAGAACAATTTTTGGATGACTTCATTGATCTTGTTATCTGGGGCCATGAACATGAGTGTAAAATAGCTC
CAACCAAAAATGAACAACAGCTGTTTTATATCTCACAACCTGGAAGCTCAGTGGTTACTTCTCTTTCCCCAGGAGAAGCTGTAAAGAAAC
ATGTTGGTTTGCTGCGTATTAAAGGGAGGAAGATGAATATGCATAAAATTCCTCTTCACACAGTGCGGCAGTTTTTCATGGAGGATATTG
TTCTAGCTAATCATCCAGACATTTTTAACCCAGATAATCCTAAAGTAACCCAAGCCATACAAAGCTTCTGTTTGGAGAAGATTGAAGAAA
TGCTTGAAAATGCTGAACGGGAACGTCTGGGTAATTCTCACCAGCCAGAGAAGCCTCTTGTACGACTGCGAGTGGACTATAGTGGAGGTT
TTGAACCTTTCAGTGTTCTTCGCTTTAGCCAGAAATTTGTGGATCGGGTAGCTAATCCAAAAGACATTATCCATTTTTTCAGGCATAGAG
AACAAAAGGAAAAAACAGGAGAAGAGATCAACTTTGGGAAACTTATCACAAAGCCTTCAGAAGGAACAACTTTAAGGGTAGAAGATCTTG
TAAAACAGTACTTTCAAACCGCAGAGAAGAATGTGCAGCTCTCACTGCTAACAGAAAGAGGGATGGGTGAAGCAGTACAAGAATTTGTGG
ACAAGGAGGAGAAAGATGCCATTGAGGAATTAGTGAAATACCAGTTGGAAAAAACACAGCGATTTCTTAAAGAACGTCATATTGATGCCC
TCGAAGACAAAATCGATGAGGAGGTACGTCGTTTCAGAGAAACCAGACAAAAAAATACTAATGAAGAAGATGATGAAGTCCGTGAGGCTA
TGACCAGGGCCAGAGCACTCAGATCTCAGTCAGAGGAGTCTGCTTCTGCCTTTAGTGCTGATGACCTTATGAGTATAGATTTAGCAGAAC
AGATGGCTAATGACTCTGATGATAGCATCTCAGCAGCAACCAACAAAGGAAGAGGCCGAGGAAGAGGTCGAAGAGGTGGAAGAGGGCAGA
ATTCAGCATCGAGAGGAGGGTCTCAAAGAGGAAGAGACACTGGTCTGGAGACTTCTACCCGTAGCAGGAACTCAAAGACTGCTGTGTCAG
CATCTAGAAATATGTCTATTATAGATGCCTTTAAATCTACAAGACAGCAGCCTTCCCGAAATGTCACTACTAAGAATTATTCAGAGGTGA
TTGAGGTAGATGAATCAGATGTGGAAGAAGACATTTTTCCTACCACTTCAAAGACAGATCAAAGGTGGTCCAGCACATCATCCAGCAAAA
TCATGTCCCAGAGTCAAGTATCGAAAGGGGTTGATTTTGAATCAAGTGAGTCACATCGATCAGACAACAACATGGCAGGACCCCAGGAAG
GCCATGCTGTCCCAGATGAACGTCACAGCCCCCACCAGTCCACCAGTGCAGCAGAATATGATGAACTCGGCTTCAGGTCCTCTTCCTGAT
GGATGGGAACAAGCCATGACTCAGGATGGAGAAATTTACTATATAAACCATAAGAACAAGACCACCTCTTGGCTAGACCCAAGGCTTGAC
CCTCGTTTTGCCATGAACCAGAGAATCAGTCAGAGTGCTCCAGTGAAACAGCCACCACCCCTGGCTCCCCAGAGCCCACAGGGAGGCGTC
ATGGGTGGCAGCAACTCCAACCAGCAGCAACAGATGCGACTGCAGCAACTGCAGATGGAGAAGGAGAGGCTGCGGCTGAAACAGCAAGAA
CTGCTTCGGCAGGTGAGGCCACAGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCT
TCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTCTCGAGATGAG
AGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGATGGATACAGGT
GATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGA
ACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCTTAATGACATG
GAGTCTGTTTTGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCTAAATCTGTGA
AGGATCTAAGGAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAAACGTCCAGCA
AGATACTTTAATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTCTAAAGAATCA
AAAGAAAAAAACTTTTTATTTCTTTTGCTATTAAAACTACTGTTCATTTTGGGGGCTGGGGGAAGTGAGCCTGTTTGGATGATGGATGCC
ATTCCTTTTGCCCAGTTAAATGTTCACCAATCATTTTAACTAAATACTCAGACTTAGAAGTCAGATGCTTCATGTCACAGCATTTAGTTT
GTTCAACAGTTGTTTCTTCAGCTTCCTTTGTCCAGTGGAAAAACATGATTTACTGGTCTGACAAGCCAAAAATGTTATATCTGATATTAA
ATACTTAATGCTGATTTGAAGAGATAGCTGAAACCAAGGCTGAAGACTGTTTTACTTTCAGTATTTTCTTTTCCTCCTAGTGCTATCATT
AGTCACATAATGACCTTGATTTTATTTTAGGAGCTTATAAGGCATGAGACAATTTCCATATAAATATATTAATTATTGCCACATACTCTA
ATATAGATTTTGGTGGATAATTTTGTGGGTGTGCATTTTGTTCTGTTTTGTTGGGTTTTTTGTTTTTTTTGTTTTTGGCAGGGTCGGTGG
GGGGGTTGGTTGGTTGGTTGGTTTTGTCGGAACCTAGGCAAATGACCATATTAGTGAATCTGTTAATAGTTGTAGCTTGGGATGGTTATT
GTAGTTGTTTTGGTAAAATCTTCATTTCCTGGTTTTTTTTACCACCTTATTTAAATCTCGATTATCTGCTCTCTCTTTTATATACATACA
CACACCCAAACATAACATTTATAATAGTGTGGTAGTGGAATGTATCCTTTTTTAGGTTTCCCTGCTTTCCAGTTAATTTTTAAAATGGTA
GCGCTTTGTATGCATTTAGAATACATGACTAGTAGTTTATATTTCACTGGTAGTTTAAATCTGGTTGGGGCAGTCTGCAGATGTTTGAAG
TAGTTTAGTGTTCTAGAAAGAGCTATTACTGTGGATAGTGCCTAGGGGAGTGCTCCACGCCCTCTGGGCATACGGTAGATATTATCTGAT
GAATTGGAAAGGAGCAAACCAGAAATGGCTTTATTTTCTCCCTTGGACTAATTTTTAAGTCTCGATTGGAATTCAGTGAGTAGGTTCATA
ATGTGCATGACAGAAATAAGCTTTATAGTGGTTTACCTTCATTTAGCTTTGGAAGTTTTCTTTGCCTTAGTTTTGGAAGTAAATTCTAGT
TTGTAGTTCTCATTTGTAATGAACACATTAACGACTAGATTAAAATATTGCCTTCAAGATTGTTCTTACTTACAAGACTTGCTCCTACTT
CTATGCTGAAAATTGACCCTGGATAGAATACTATAAGGTTTTGAGTTAGCTGGAAAAGTGATCAGATTAATAAATGTATATTGGTAGTTG
AATTTAGCAAAGAAATAGAGATAATCATGATTATACCTTTATTTTTACAGGAAGAGATGATGTAACTAGAGTATGTGTCTACAGGAGTAA
TAATGGTTTCCAAAGAGTATTTTTTAAAGGAACAAAACGAGCATGAATTAACTCTTCAATATAAGCTATGAAGTAATAGTTGGTTGTGAA
TTAAAGTGGCACCAGCTAGCACCTCTGTGTTTTAAGGGTCTTTCAATGTTTCTAGAATAAGCCCTTATTTTCAAGGGTTCATAACAGGCA
TAAAATCTCTTCTCCTGGCAAAAGCTGCTATGAAAAGCCTCAGCTTGGGAAGATAGATTTTTTTCCCCCCAATTACAAAATCTAAGTATT
TTGGCCCTTCAATTTGGAGGAGGGCAAAAGTTGGAAGTAAGAAGTTTTATTTTAAGTACTTTCAGTGCTCAAAAAAATGCAATCACTGTG
TTGTATATAATAGTTCATAGGTTGATCACTCATAATAATTGACTCTAAGGCTTTTATTAAGAAAACAGCAGAAAGATTAAATCTTGAATT
AAGTCTGGGGGGAAATGGCCACTGCAGATGGAGTTTTAGAGTAGTAATGAAATTCTACCTAGAATGCAAAATTGGGTATATGAATTACAT
AGCATGTTGTTGGGATTTTTTTTAATGTGCAGAAGATCAAAGCTACTTGGAAGGAGTGCCTATAATTTGCCAGTAGCCACAGATTAAGAT
TATATCTTATATATCAGCAGATTAGCTTTAGCTTAGGGGGAGGGTGGGAAAGTTTGGGGGGGGGGTTGTGAAGATTTAGGGGGACCTTGA
TAGAGAACTTTATAAACTTCTTTCTCTTTAATAAAGACTTGTCTTACACCGTGCTGCCATTAAAGGCAGCTGTTCTAGAGTTTCAGTCAC
CTAAGTACACCCACAAAACAATATGAATATGGAGATCTTCCTTTACCCCTCAACTTTAATTTGCCCAGTTATACCTCAGTGTTGTAGCAG
TACTGTGATACCTGGCACAGTGCTTTGATCTTACGATGCCCTCTGTACTGACCTGAAGGAGACCTAAGAGTCCTTTCCCTTTTTGAGTTT
GAATCATAGCCTTGATGTGGTCTCTTGTTTTATGTCCTTGTTCCTAATGTAAAAGTGCTTAACTGCTTCTTGGTTGTATTGGGTAGCATT
GGGATAAGATTTTAACTGGGTATTCTTGAATTGCTTTTACAATAAACCAATTTTATAATCTTTAAATTTATCAACTTTTTACATTTGTGT
TATTTTCAGTCAGGGCTTCTTAGATCTACTTATGGTTGATGGAGCACATTGATTTGGAGTTTCAGATCTTCCAAAGCACTATTTGTTGTA
ATAACTTTTCTAAATGTAGTGCCTTTAAAGGAAAAATGAACACAGGGAAGTGACTTTGCTACAAATAATGTTGCTGTGTTAAGTATTCAT
ATTAAATACATGCCTTCTATATGGAACATGGCAGAAAGACTGAAAAATAACAGTAATTAATTGTGTAATTCAGAATTCATACCAATCAGT
GTTGAAACTCAAACATTGCAAAAGTGGGTGGCAATATTCAGTGCTTAACACTTTTCTAGCGTTGGTACATCTGAGAAATGAGTGCTCAGG
TGGATTTTATCCTCGCAAGCATGTTGTTATAAGAATTGTGGGTGTGCCTATCATAACAATTGTTTTCTGTATCTTGAAAAAGTATTCTCC
ACATTTTAAATGTTTTATATTAGAGAATTCTTTAATGCACACTTGTCAAATATATATATATAGTACCAATGTTACCTTTTTATTTTTTGT
TTTAGATGTAAGAGCATGCTCATATGTTAGGTACTTACATAAATTGTTACATTATTTTTTCTTATGTAATACCTTTTTGTTTGTTTATGT

>In-frame_ENST00000393241_ENST00000537274_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(amino acids)=735AA_start in transcript=221_stop in transcript=2428
MTIKMSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGD
RPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKI
ALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQP
GSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSH
QPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQL
SLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEES
ASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRDTGLETSTRSRNSKTAVSASRNMSIIDAFKST
RQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSESHRSDNNMAGPQEGHAVPDERHSPHQS

--------------------------------------------------------------
>In-frame_ENST00000393241_ENST00000345877_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(transcript)=6576nt_BP=2300nt
AAACGGACGCCGTTCTCTCCCGCGGAATTCAGGTTTACGGCCCTGCGGGTTCTCAGAGGCAAGTTCAGACCGTGTTGTTTTCTTTTCACG
GATCCTGCCCTTTCTTCCCGAAAAGAAGACAGCCTTGGAATTTCTAGAATTTGGAATCGAGTGCATTTTCTGACATTTGAGTACAGTACC
CAGGGGTTCTTGGAGAAGAACCTGGTCCCAGAGGAGCTTGACTGACCATAAAAATGAGTACTGCAGATGCACTTGATGATGAAAACACAT
TTAAAATATTAGTTGCAACAGATATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGATACGTTTGTAACACTCGATGAAA
TTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTTTTTCATGAAAATAAGCCCTCAAGGAAAACATTAC
ATACCTGCCTCGAGTTATTAAGAAAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTGATCAGTCAGTCAACTTTGGTT
TTAGTAAGTTTCCATGGGTGAACTATCAAGATGGCAACCTCAACATTTCAATTCCAGTGTTTAGTATTCATGGCAATCATGACGATCCCA
CAGGGGCAGATGCACTTTGTGCCTTGGACATTTTAAGTTGTGCTGGATTTGTAAATCACTTTGGACGTTCAATGTCTGTGGAGAAGATAG
ACATTAGTCCGGTTTTGCTTCAAAAAGGAAGCACAAAGATTGCGCTATATGGTTTAGGATCCATTCCAGATGAAAGGCTCTATCGAATGT
TTGTCAATAAAAAAGTAACAATGTTGAGACCAAAGGAAGATGAGAACTCTTGGTTTAACTTATTTGTGATTCATCAGAACAGGAGTAAAC
ATGGAAGTACTAACTTCATTCCAGAACAATTTTTGGATGACTTCATTGATCTTGTTATCTGGGGCCATGAACATGAGTGTAAAATAGCTC
CAACCAAAAATGAACAACAGCTGTTTTATATCTCACAACCTGGAAGCTCAGTGGTTACTTCTCTTTCCCCAGGAGAAGCTGTAAAGAAAC
ATGTTGGTTTGCTGCGTATTAAAGGGAGGAAGATGAATATGCATAAAATTCCTCTTCACACAGTGCGGCAGTTTTTCATGGAGGATATTG
TTCTAGCTAATCATCCAGACATTTTTAACCCAGATAATCCTAAAGTAACCCAAGCCATACAAAGCTTCTGTTTGGAGAAGATTGAAGAAA
TGCTTGAAAATGCTGAACGGGAACGTCTGGGTAATTCTCACCAGCCAGAGAAGCCTCTTGTACGACTGCGAGTGGACTATAGTGGAGGTT
TTGAACCTTTCAGTGTTCTTCGCTTTAGCCAGAAATTTGTGGATCGGGTAGCTAATCCAAAAGACATTATCCATTTTTTCAGGCATAGAG
AACAAAAGGAAAAAACAGGAGAAGAGATCAACTTTGGGAAACTTATCACAAAGCCTTCAGAAGGAACAACTTTAAGGGTAGAAGATCTTG
TAAAACAGTACTTTCAAACCGCAGAGAAGAATGTGCAGCTCTCACTGCTAACAGAAAGAGGGATGGGTGAAGCAGTACAAGAATTTGTGG
ACAAGGAGGAGAAAGATGCCATTGAGGAATTAGTGAAATACCAGTTGGAAAAAACACAGCGATTTCTTAAAGAACGTCATATTGATGCCC
TCGAAGACAAAATCGATGAGGAGGTACGTCGTTTCAGAGAAACCAGACAAAAAAATACTAATGAAGAAGATGATGAAGTCCGTGAGGCTA
TGACCAGGGCCAGAGCACTCAGATCTCAGTCAGAGGAGTCTGCTTCTGCCTTTAGTGCTGATGACCTTATGAGTATAGATTTAGCAGAAC
AGATGGCTAATGACTCTGATGATAGCATCTCAGCAGCAACCAACAAAGGAAGAGGCCGAGGAAGAGGTCGAAGAGGTGGAAGAGGGCAGA
ATTCAGCATCGAGAGGAGGGTCTCAAAGAGGAAGAGACACTGGTCTGGAGACTTCTACCCGTAGCAGGAACTCAAAGACTGCTGTGTCAG
CATCTAGAAATATGTCTATTATAGATGCCTTTAAATCTACAAGACAGCAGCCTTCCCGAAATGTCACTACTAAGAATTATTCAGAGGTGA
TTGAGGTAGATGAATCAGATGTGGAAGAAGACATTTTTCCTACCACTTCAAAGACAGATCAAAGGTGGTCCAGCACATCATCCAGCAAAA
TCATGTCCCAGAGTCAAGTATCGAAAGGGGTTGATTTTGAATCAAGTGAGTCACATCGATCAGACAACAACATGGCAGGACCCCAGGAAG
GCCATGCTGTCCCAGATGAACGTCACAGCCCCCACCAGTCCACCAGTGCAGCAGAATATGATGAACTCGGCTTCAGCCATGAACCAGAGA
ATCAGTCAGAGTGCTCCAGTGAAACAGCCACCACCCCTGGCTCCCCAGAGCCCACAGGGAGGCGTCATGGGTGGCAGCAACTCCAACCAG
CAGCAACAGATGCGACTGCAGCAACTGCAGATGGAGAAGGAGAGGCTGCGGCTGAAACAGCAAGAACTGCTTCGGCAGGTGAGGCCACAG
GAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTG
AGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATG
AGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTG
CCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAAC
ATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCTTAATGACATGGAGTCTGTTTTGGCTGCCACCAAG
CTAGATAAAGAAAGCTTTCTTACATGGTTATAGAGCCCTCAGGCAGACTGAATTCTAAATCTGTGAAGGATCTAAGGAGACACATGCACC
GGAAATTTCCATAAGCCAGTTGCAGTTTTCAGGCTAATACAGAAAAAGATGAACAAACGTCCAGCAAGATACTTTAATCCTCTATTTTGC
TCTTCCTTGTCCATTGCTGCTGTTAATGTATTGCTGACCTCTTTCACAGTTGGCTCTAAAGAATCAAAAGAAAAAAACTTTTTATTTCTT
TTGCTATTAAAACTACTGTTCATTTTGGGGGCTGGGGGAAGTGAGCCTGTTTGGATGATGGATGCCATTCCTTTTGCCCAGTTAAATGTT
CACCAATCATTTTAACTAAATACTCAGACTTAGAAGTCAGATGCTTCATGTCACAGCATTTAGTTTGTTCAACAGTTGTTTCTTCAGCTT
CCTTTGTCCAGTGGAAAAACATGATTTACTGGTCTGACAAGCCAAAAATGTTATATCTGATATTAAATACTTAATGCTGATTTGAAGAGA
TAGCTGAAACCAAGGCTGAAGACTGTTTTACTTTCAGTATTTTCTTTTCCTCCTAGTGCTATCATTAGTCACATAATGACCTTGATTTTA
TTTTAGGAGCTTATAAGGCATGAGACAATTTCCATATAAATATATTAATTATTGCCACATACTCTAATATAGATTTTGGTGGATAATTTT
GTGGGTGTGCATTTTGTTCTGTTTTGTTGGGTTTTTTGTTTTTTTTGTTTTTGGCAGGGTCGGTGGGGGGGTTGGTTGGTTGGTTGGTTT
TGTCGGAACCTAGGCAAATGACCATATTAGTGAATCTGTTAATAGTTGTAGCTTGGGATGGTTATTGTAGTTGTTTTGGTAAAATCTTCA
TTTCCTGGTTTTTTTTACCACCTTATTTAAATCTCGATTATCTGCTCTCTCTTTTATATACATACACACACCCAAACATAACATTTATAA
TAGTGTGGTAGTGGAATGTATCCTTTTTTAGGTTTCCCTGCTTTCCAGTTAATTTTTAAAATGGTAGCGCTTTGTATGCATTTAGAATAC
ATGACTAGTAGTTTATATTTCACTGGTAGTTTAAATCTGGTTGGGGCAGTCTGCAGATGTTTGAAGTAGTTTAGTGTTCTAGAAAGAGCT
ATTACTGTGGATAGTGCCTAGGGGAGTGCTCCACGCCCTCTGGGCATACGGTAGATATTATCTGATGAATTGGAAAGGAGCAAACCAGAA
ATGGCTTTATTTTCTCCCTTGGACTAATTTTTAAGTCTCGATTGGAATTCAGTGAGTAGGTTCATAATGTGCATGACAGAAATAAGCTTT
ATAGTGGTTTACCTTCATTTAGCTTTGGAAGTTTTCTTTGCCTTAGTTTTGGAAGTAAATTCTAGTTTGTAGTTCTCATTTGTAATGAAC
ACATTAACGACTAGATTAAAATATTGCCTTCAAGATTGTTCTTACTTACAAGACTTGCTCCTACTTCTATGCTGAAAATTGACCCTGGAT
AGAATACTATAAGGTTTTGAGTTAGCTGGAAAAGTGATCAGATTAATAAATGTATATTGGTAGTTGAATTTAGCAAAGAAATAGAGATAA
TCATGATTATACCTTTATTTTTACAGGAAGAGATGATGTAACTAGAGTATGTGTCTACAGGAGTAATAATGGTTTCCAAAGAGTATTTTT
TAAAGGAACAAAACGAGCATGAATTAACTCTTCAATATAAGCTATGAAGTAATAGTTGGTTGTGAATTAAAGTGGCACCAGCTAGCACCT
CTGTGTTTTAAGGGTCTTTCAATGTTTCTAGAATAAGCCCTTATTTTCAAGGGTTCATAACAGGCATAAAATCTCTTCTCCTGGCAAAAG
CTGCTATGAAAAGCCTCAGCTTGGGAAGATAGATTTTTTTCCCCCCAATTACAAAATCTAAGTATTTTGGCCCTTCAATTTGGAGGAGGG
CAAAAGTTGGAAGTAAGAAGTTTTATTTTAAGTACTTTCAGTGCTCAAAAAAATGCAATCACTGTGTTGTATATAATAGTTCATAGGTTG
ATCACTCATAATAATTGACTCTAAGGCTTTTATTAAGAAAACAGCAGAAAGATTAAATCTTGAATTAAGTCTGGGGGGAAATGGCCACTG
CAGATGGAGTTTTAGAGTAGTAATGAAATTCTACCTAGAATGCAAAATTGGGTATATGAATTACATAGCATGTTGTTGGGATTTTTTTTA
ATGTGCAGAAGATCAAAGCTACTTGGAAGGAGTGCCTATAATTTGCCAGTAGCCACAGATTAAGATTATATCTTATATATCAGCAGATTA
GCTTTAGCTTAGGGGGAGGGTGGGAAAGTTTGGGGGGGGGGTTGTGAAGATTTAGGGGGACCTTGATAGAGAACTTTATAAACTTCTTTC
TCTTTAATAAAGACTTGTCTTACACCGTGCTGCCATTAAAGGCAGCTGTTCTAGAGTTTCAGTCACCTAAGTACACCCACAAAACAATAT
GAATATGGAGATCTTCCTTTACCCCTCAACTTTAATTTGCCCAGTTATACCTCAGTGTTGTAGCAGTACTGTGATACCTGGCACAGTGCT
TTGATCTTACGATGCCCTCTGTACTGACCTGAAGGAGACCTAAGAGTCCTTTCCCTTTTTGAGTTTGAATCATAGCCTTGATGTGGTCTC
TTGTTTTATGTCCTTGTTCCTAATGTAAAAGTGCTTAACTGCTTCTTGGTTGTATTGGGTAGCATTGGGATAAGATTTTAACTGGGTATT
CTTGAATTGCTTTTACAATAAACCAATTTTATAATCTTTAAATTTATCAACTTTTTACATTTGTGTTATTTTCAGTCAGGGCTTCTTAGA
TCTACTTATGGTTGATGGAGCACATTGATTTGGAGTTTCAGATCTTCCAAAGCACTATTTGTTGTAATAACTTTTCTAAATGTAGTGCCT
TTAAAGGAAAAATGAACACAGGGAAGTGACTTTGCTACAAATAATGTTGCTGTGTTAAGTATTCATATTAAATACATGCCTTCTATATGG
AACATGGCAGAAAGACTGAAAAATAACAGTAATTAATTGTGTAATTCAGAATTCATACCAATCAGTGTTGAAACTCAAACATTGCAAAAG
TGGGTGGCAATATTCAGTGCTTAACACTTTTCTAGCGTTGGTACATCTGAGAAATGAGTGCTCAGGTGGATTTTATCCTCGCAAGCATGT
TGTTATAAGAATTGTGGGTGTGCCTATCATAACAATTGTTTTCTGTATCTTGAAAAAGTATTCTCCACATTTTAAATGTTTTATATTAGA
GAATTCTTTAATGCACACTTGTCAAATATATATATATAGTACCAATGTTACCTTTTTATTTTTTGTTTTAGATGTAAGAGCATGCTCATA
TGTTAGGTACTTACATAAATTGTTACATTATTTTTTCTTATGTAATACCTTTTTGTTTGTTTATGTGGTTCAAATATATTCTTTCCTTAA

>In-frame_ENST00000393241_ENST00000345877_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(amino acids)=801AA_start in transcript=221_stop in transcript=2626
MTIKMSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGD
RPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKI
ALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQP
GSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSH
QPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQL
SLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEES
ASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRDTGLETSTRSRNSKTAVSASRNMSIIDAFKST
RQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSESHRSDNNMAGPQEGHAVPDERHSPHQS

--------------------------------------------------------------
>In-frame_ENST00000393241_ENST00000531439_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(transcript)=3218nt_BP=2300nt
AAACGGACGCCGTTCTCTCCCGCGGAATTCAGGTTTACGGCCCTGCGGGTTCTCAGAGGCAAGTTCAGACCGTGTTGTTTTCTTTTCACG
GATCCTGCCCTTTCTTCCCGAAAAGAAGACAGCCTTGGAATTTCTAGAATTTGGAATCGAGTGCATTTTCTGACATTTGAGTACAGTACC
CAGGGGTTCTTGGAGAAGAACCTGGTCCCAGAGGAGCTTGACTGACCATAAAAATGAGTACTGCAGATGCACTTGATGATGAAAACACAT
TTAAAATATTAGTTGCAACAGATATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGATACGTTTGTAACACTCGATGAAA
TTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTTTTTCATGAAAATAAGCCCTCAAGGAAAACATTAC
ATACCTGCCTCGAGTTATTAAGAAAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTGATCAGTCAGTCAACTTTGGTT
TTAGTAAGTTTCCATGGGTGAACTATCAAGATGGCAACCTCAACATTTCAATTCCAGTGTTTAGTATTCATGGCAATCATGACGATCCCA
CAGGGGCAGATGCACTTTGTGCCTTGGACATTTTAAGTTGTGCTGGATTTGTAAATCACTTTGGACGTTCAATGTCTGTGGAGAAGATAG
ACATTAGTCCGGTTTTGCTTCAAAAAGGAAGCACAAAGATTGCGCTATATGGTTTAGGATCCATTCCAGATGAAAGGCTCTATCGAATGT
TTGTCAATAAAAAAGTAACAATGTTGAGACCAAAGGAAGATGAGAACTCTTGGTTTAACTTATTTGTGATTCATCAGAACAGGAGTAAAC
ATGGAAGTACTAACTTCATTCCAGAACAATTTTTGGATGACTTCATTGATCTTGTTATCTGGGGCCATGAACATGAGTGTAAAATAGCTC
CAACCAAAAATGAACAACAGCTGTTTTATATCTCACAACCTGGAAGCTCAGTGGTTACTTCTCTTTCCCCAGGAGAAGCTGTAAAGAAAC
ATGTTGGTTTGCTGCGTATTAAAGGGAGGAAGATGAATATGCATAAAATTCCTCTTCACACAGTGCGGCAGTTTTTCATGGAGGATATTG
TTCTAGCTAATCATCCAGACATTTTTAACCCAGATAATCCTAAAGTAACCCAAGCCATACAAAGCTTCTGTTTGGAGAAGATTGAAGAAA
TGCTTGAAAATGCTGAACGGGAACGTCTGGGTAATTCTCACCAGCCAGAGAAGCCTCTTGTACGACTGCGAGTGGACTATAGTGGAGGTT
TTGAACCTTTCAGTGTTCTTCGCTTTAGCCAGAAATTTGTGGATCGGGTAGCTAATCCAAAAGACATTATCCATTTTTTCAGGCATAGAG
AACAAAAGGAAAAAACAGGAGAAGAGATCAACTTTGGGAAACTTATCACAAAGCCTTCAGAAGGAACAACTTTAAGGGTAGAAGATCTTG
TAAAACAGTACTTTCAAACCGCAGAGAAGAATGTGCAGCTCTCACTGCTAACAGAAAGAGGGATGGGTGAAGCAGTACAAGAATTTGTGG
ACAAGGAGGAGAAAGATGCCATTGAGGAATTAGTGAAATACCAGTTGGAAAAAACACAGCGATTTCTTAAAGAACGTCATATTGATGCCC
TCGAAGACAAAATCGATGAGGAGGTACGTCGTTTCAGAGAAACCAGACAAAAAAATACTAATGAAGAAGATGATGAAGTCCGTGAGGCTA
TGACCAGGGCCAGAGCACTCAGATCTCAGTCAGAGGAGTCTGCTTCTGCCTTTAGTGCTGATGACCTTATGAGTATAGATTTAGCAGAAC
AGATGGCTAATGACTCTGATGATAGCATCTCAGCAGCAACCAACAAAGGAAGAGGCCGAGGAAGAGGTCGAAGAGGTGGAAGAGGGCAGA
ATTCAGCATCGAGAGGAGGGTCTCAAAGAGGAAGAGACACTGGTCTGGAGACTTCTACCCGTAGCAGGAACTCAAAGACTGCTGTGTCAG
CATCTAGAAATATGTCTATTATAGATGCCTTTAAATCTACAAGACAGCAGCCTTCCCGAAATGTCACTACTAAGAATTATTCAGAGGTGA
TTGAGGTAGATGAATCAGATGTGGAAGAAGACATTTTTCCTACCACTTCAAAGACAGATCAAAGGTGGTCCAGCACATCATCCAGCAAAA
TCATGTCCCAGAGTCAAGTATCGAAAGGGGTTGATTTTGAATCAAGTGAGTCACATCGATCAGACAACAACATGGCAGGACCCCAGGAAG
GCCATGCTGTCCCAGATGAACGTCACAGCCCCCACCAGTCCACCAGTGCAGCAGAATATGATGAACTCGGCTTCAGGTCCTCTTCCTGAT
GGATGGGAACAAGCCATGACTCAGGATGGAGAAATTTACTATATAAACCATAAGAACAAGACCACCTCTTGGCTAGACCCAAGGCTTGAC
CCTCGTTTTGCCATGAACCAGAGAATCAGTCAGAGTGCTCCAGTGAAACAGCCACCACCCCTGGCTCCCCAGAGCCCACAGGGAGGCGTC
ATGGGTGGCAGCAACTCCAACCAGCAGCAACAGATGCGACTGCAGCAACTGCAGATGGAGAAGGAGAGGCTGCGGCTGAAACAGCAAGAA
CTGCTTCGGCAGGAGTTAGCCCTGCGTAGCCAGTTACCAACACTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCTTCTCCCGGGATG
TCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCTTTCCTTAACAGTGGCACCTATCACTCTCGAGATGAGAGTACAGACAGT
GGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGATGACTTCCTGAACAGTGTGGATGAGATGGATACAGGTGATACTATCAAC
CAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTACCTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGAACACTGGAAGGA
GATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTGCAGGAAGCTTTGAGTTCTGACATCCTTAATGACATGGAGTCTGTTTTG

>In-frame_ENST00000393241_ENST00000531439_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(amino acids)=735AA_start in transcript=221_stop in transcript=2428
MTIKMSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGD
RPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKI
ALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQP
GSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSH
QPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQL
SLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEES
ASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRDTGLETSTRSRNSKTAVSASRNMSIIDAFKST
RQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSESHRSDNNMAGPQEGHAVPDERHSPHQS

--------------------------------------------------------------
>In-frame_ENST00000393241_ENST00000524575_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(transcript)=3455nt_BP=2300nt
AAACGGACGCCGTTCTCTCCCGCGGAATTCAGGTTTACGGCCCTGCGGGTTCTCAGAGGCAAGTTCAGACCGTGTTGTTTTCTTTTCACG
GATCCTGCCCTTTCTTCCCGAAAAGAAGACAGCCTTGGAATTTCTAGAATTTGGAATCGAGTGCATTTTCTGACATTTGAGTACAGTACC
CAGGGGTTCTTGGAGAAGAACCTGGTCCCAGAGGAGCTTGACTGACCATAAAAATGAGTACTGCAGATGCACTTGATGATGAAAACACAT
TTAAAATATTAGTTGCAACAGATATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGATACGTTTGTAACACTCGATGAAA
TTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTTTTTCATGAAAATAAGCCCTCAAGGAAAACATTAC
ATACCTGCCTCGAGTTATTAAGAAAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTGATCAGTCAGTCAACTTTGGTT
TTAGTAAGTTTCCATGGGTGAACTATCAAGATGGCAACCTCAACATTTCAATTCCAGTGTTTAGTATTCATGGCAATCATGACGATCCCA
CAGGGGCAGATGCACTTTGTGCCTTGGACATTTTAAGTTGTGCTGGATTTGTAAATCACTTTGGACGTTCAATGTCTGTGGAGAAGATAG
ACATTAGTCCGGTTTTGCTTCAAAAAGGAAGCACAAAGATTGCGCTATATGGTTTAGGATCCATTCCAGATGAAAGGCTCTATCGAATGT
TTGTCAATAAAAAAGTAACAATGTTGAGACCAAAGGAAGATGAGAACTCTTGGTTTAACTTATTTGTGATTCATCAGAACAGGAGTAAAC
ATGGAAGTACTAACTTCATTCCAGAACAATTTTTGGATGACTTCATTGATCTTGTTATCTGGGGCCATGAACATGAGTGTAAAATAGCTC
CAACCAAAAATGAACAACAGCTGTTTTATATCTCACAACCTGGAAGCTCAGTGGTTACTTCTCTTTCCCCAGGAGAAGCTGTAAAGAAAC
ATGTTGGTTTGCTGCGTATTAAAGGGAGGAAGATGAATATGCATAAAATTCCTCTTCACACAGTGCGGCAGTTTTTCATGGAGGATATTG
TTCTAGCTAATCATCCAGACATTTTTAACCCAGATAATCCTAAAGTAACCCAAGCCATACAAAGCTTCTGTTTGGAGAAGATTGAAGAAA
TGCTTGAAAATGCTGAACGGGAACGTCTGGGTAATTCTCACCAGCCAGAGAAGCCTCTTGTACGACTGCGAGTGGACTATAGTGGAGGTT
TTGAACCTTTCAGTGTTCTTCGCTTTAGCCAGAAATTTGTGGATCGGGTAGCTAATCCAAAAGACATTATCCATTTTTTCAGGCATAGAG
AACAAAAGGAAAAAACAGGAGAAGAGATCAACTTTGGGAAACTTATCACAAAGCCTTCAGAAGGAACAACTTTAAGGGTAGAAGATCTTG
TAAAACAGTACTTTCAAACCGCAGAGAAGAATGTGCAGCTCTCACTGCTAACAGAAAGAGGGATGGGTGAAGCAGTACAAGAATTTGTGG
ACAAGGAGGAGAAAGATGCCATTGAGGAATTAGTGAAATACCAGTTGGAAAAAACACAGCGATTTCTTAAAGAACGTCATATTGATGCCC
TCGAAGACAAAATCGATGAGGAGGTACGTCGTTTCAGAGAAACCAGACAAAAAAATACTAATGAAGAAGATGATGAAGTCCGTGAGGCTA
TGACCAGGGCCAGAGCACTCAGATCTCAGTCAGAGGAGTCTGCTTCTGCCTTTAGTGCTGATGACCTTATGAGTATAGATTTAGCAGAAC
AGATGGCTAATGACTCTGATGATAGCATCTCAGCAGCAACCAACAAAGGAAGAGGCCGAGGAAGAGGTCGAAGAGGTGGAAGAGGGCAGA
ATTCAGCATCGAGAGGAGGGTCTCAAAGAGGAAGAGACACTGGTCTGGAGACTTCTACCCGTAGCAGGAACTCAAAGACTGCTGTGTCAG
CATCTAGAAATATGTCTATTATAGATGCCTTTAAATCTACAAGACAGCAGCCTTCCCGAAATGTCACTACTAAGAATTATTCAGAGGTGA
TTGAGGTAGATGAATCAGATGTGGAAGAAGACATTTTTCCTACCACTTCAAAGACAGATCAAAGGTGGTCCAGCACATCATCCAGCAAAA
TCATGTCCCAGAGTCAAGTATCGAAAGGGGTTGATTTTGAATCAAGTGAGTCACATCGATCAGACAACAACATGGCAGGACCCCAGGAAG
GCCATGCTGTCCCAGATGAACGTCACAGCCCCCACCAGTCCACCAGTGCAGCAGAATATGATGAACTCGGCTTCAGGTCCTCTTCCTGAT
GGATGGGAACAAGCCATGACTCAGGATGGAGAAATTTACTATATAAACCATAAGAACAAGACCACCTCTTGGCTAGACCCAAGGCTTGAC
CCTCGTTTTGCCATGAACCAGAGAATCAGTCAGAGTGCTCCAGTGAAACAGCCACCACCCCTGGCTCCCCAGAGCCCACAGGGAGGCGTC
ATGGGTGGCAGCAACTCCAACCAGCAGCAACAGATGCGACTGCAGCAACTGCAGATGGAGAAGGAGAGGCTGCGGCTGAAACAGCAAGAA
CTGCTTCGGCAGGCAATGCGGAATATCAATCCCAGCACAGCAAATTCTCCAAAATGTCAGGAGTTAGCCCTGCGTAGCCAGTTACCAACA
CTGGAGCAGGATGGTGGGACTCAAAATCCAGTGTCTTCTCCCGGGATGTCTCAGGAATTGAGAACAATGACGACCAATAGCTCAGATCCT
TTCCTTAACAGTGGCACCTATCACTCTCGAGATGAGAGTACAGACAGTGGACTAAGCATGAGCAGCTACAGTGTCCCTCGAACCCCAGAT
GACTTCCTGAACAGTGTGGATGAGATGGATACAGGTGATACTATCAACCAAAGCACCCTGCCCTCACAGCAGAACCGTTTCCCAGACTAC
CTTGAAGCCATTCCTGGGACAAATGTGGACCTTGGAACACTGGAAGGAGATGGAATGAACATAGAAGGAGAGGAGCTGATGCCAAGTCTG
CAGGAAGCTTTGAGTTCTGACATCCTTAATGACATGGAGTCTGTTTTGGCTGCCACCAAGCTAGATAAAGAAAGCTTTCTTACATGGTTA
TAGAGCCCTCAGGCAGACTGAATTCTAAATCTGTGAAGGATCTAAGGAGACACATGCACCGGAAATTTCCATAAGCCAGTTGCAGTTTTC
AGGCTAATACAGAAAAAGATGAACAAACGTCCAGCAAGATACTTTAATCCTCTATTTTGCTCTTCCTTGTCCATTGCTGCTGTTAATGTA

>In-frame_ENST00000393241_ENST00000524575_TCGA-DU-5855-01A_MRE11A_chr11_94163077_-_YAP1_chr11_102033187_length(amino acids)=735AA_start in transcript=221_stop in transcript=2428
MTIKMSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGD
RPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKI
ALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQP
GSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSH
QPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQL
SLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEES
ASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRDTGLETSTRSRNSKTAVSASRNMSIIDAFKST
RQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSESHRSDNNMAGPQEGHAVPDERHSPHQS

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Fusion Gene PPI Analysis for MRE11A-YAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MRE11A-YAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MRE11A-YAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneYAP1C3805432COLOBOMA, OCULAR, WITH OR WITHOUT HEARING IMPAIRMENT, CLEFT LIP/PALATE, AND/OR MENTAL RETARDATION3CTD_human;GENOMICS_ENGLAND
TgeneYAP1C0006118Brain Neoplasms1CTD_human
TgeneYAP1C0006142Malignant neoplasm of breast1CTD_human
TgeneYAP1C0009402Colorectal Carcinoma1CTD_human
TgeneYAP1C0009404Colorectal Neoplasms1CTD_human
TgeneYAP1C0018916Hemangioma1CTD_human
TgeneYAP1C0027627Neoplasm Metastasis1CTD_human
TgeneYAP1C0027819Neuroblastoma1CTD_human
TgeneYAP1C0153633Malignant neoplasm of brain1CTD_human
TgeneYAP1C0205788Histiocytoid hemangioma1CTD_human
TgeneYAP1C0205789Hemangioma, Intramuscular1CTD_human
TgeneYAP1C0206656Embryonal Rhabdomyosarcoma1CTD_human
TgeneYAP1C0206732Epithelioid hemangioendothelioma1ORPHANET
TgeneYAP1C0235874Disease Exacerbation1CTD_human
TgeneYAP1C0496899Benign neoplasm of brain, unspecified1CTD_human
TgeneYAP1C0677608Chorioangioma1CTD_human
TgeneYAP1C0678222Breast Carcinoma1CTD_human
TgeneYAP1C0750974Brain Tumor, Primary1CTD_human
TgeneYAP1C0750977Recurrent Brain Neoplasm1CTD_human
TgeneYAP1C0750979Primary malignant neoplasm of brain1CTD_human
TgeneYAP1C0795902Coloboma, cleft lip-palate and mental retardation syndrome1ORPHANET
TgeneYAP1C0919267ovarian neoplasm1CTD_human
TgeneYAP1C1140680Malignant neoplasm of ovary1CTD_human
TgeneYAP1C1168401Squamous cell carcinoma of the head and neck1CTD_human
TgeneYAP1C1257931Mammary Neoplasms, Human1CTD_human
TgeneYAP1C1458155Mammary Neoplasms1CTD_human
TgeneYAP1C1527390Neoplasms, Intracranial1CTD_human
TgeneYAP1C1959588Angioma1CTD_human
TgeneYAP1C2239176Liver carcinoma1CTD_human
TgeneYAP1C3539878Triple Negative Breast Neoplasms1CTD_human
TgeneYAP1C4704874Mammary Carcinoma, Human1CTD_human