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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APC-NREP (FusionGDB2 ID:5478)

Fusion Gene Summary for APC-NREP

check button Fusion gene summary
Fusion gene informationFusion gene name: APC-NREP
Fusion gene ID: 5478
HgeneTgene
Gene symbol

APC

NREP

Gene ID

5624

9315

Gene nameprotein C, inactivator of coagulation factors Va and VIIIaneuronal regeneration related protein
SynonymsAPC|PC|PROC1|THPH3|THPH4C5orf13|D4S114|P311|PRO1873|PTZ17|SEZ17
Cytomap

2q14.3

5q22.1

Type of geneprotein-codingprotein-coding
Descriptionvitamin K-dependent protein CProtein C-Nagoyaactivated protein Canticoagulant protein Cautoprothrombin IIAblood coagulation factor XIVprepro-protein Ctype I protein Cneuronal regeneration-related proteinneuronal protein 3.1neuronal regeneration related protein homologprotein p311
Modification date2020031320200313
UniProtAcc

P25054

Q16612

Ensembl transtripts involved in fusion geneENST00000505350, ENST00000457016, 
ENST00000257430, ENST00000508376, 
ENST00000395634, ENST00000450761, 
ENST00000509025, ENST00000379671, 
ENST00000257435, ENST00000447165, 
ENST00000446294, ENST00000515855, 
ENST00000507742, ENST00000509979, 
ENST00000419114, ENST00000509427, 
ENST00000453526, ENST00000455559, 
ENST00000508870, 
Fusion gene scores* DoF score14 X 10 X 8=11209 X 8 X 5=360
# samples 1410
** MAII scorelog2(14/1120*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APC [Title/Abstract] AND NREP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPC(112043579)-NREP(111071204), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across APC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NREP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A195-06AAPCchr5

112043579

+NREPchr5

111071204

-
ChimerDB4SKCMTCGA-ER-A195APCchr5

112043579

+NREPchr5

111071204

-
ChimerDB4SKCMTCGA-ER-A195-06AAPCchr5

112043579

+NREPchr5

111071204

-
ChimerDB4SKCMTCGA-ER-A195-06AAPCchr5

112043346

+NREPchr5

111071204

-


Top

Fusion Gene ORF analysis for APC-NREP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000505350ENST00000395634APCchr5

112043579

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000450761APCchr5

112043579

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000509025APCchr5

112043579

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000379671APCchr5

112043579

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000257435APCchr5

112043579

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000447165APCchr5

112043579

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000446294APCchr5

112043579

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000515855APCchr5

112043579

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000507742APCchr5

112043579

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000509979APCchr5

112043579

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000419114APCchr5

112043579

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000509427APCchr5

112043579

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000453526APCchr5

112043579

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000455559APCchr5

112043579

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000508870APCchr5

112043579

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000395634APCchr5

112043579

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000450761APCchr5

112043579

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000509025APCchr5

112043579

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000379671APCchr5

112043579

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000257435APCchr5

112043579

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000447165APCchr5

112043579

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000446294APCchr5

112043579

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000515855APCchr5

112043579

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000507742APCchr5

112043579

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000509979APCchr5

112043579

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000419114APCchr5

112043579

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000509427APCchr5

112043579

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000453526APCchr5

112043579

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000455559APCchr5

112043579

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000508870APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000395634APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000450761APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000509025APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000379671APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000257435APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000447165APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000446294APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000515855APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000507742APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000509979APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000419114APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000509427APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000453526APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000455559APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000508870APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000395634APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000450761APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000509025APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000379671APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000257435APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000447165APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000446294APCchr5

112043579

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000515855APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000507742APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000509979APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000419114APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000509427APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000453526APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000455559APCchr5

112043579

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000508870APCchr5

112043579

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000395634APCchr5

112043346

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000450761APCchr5

112043346

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000509025APCchr5

112043346

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000379671APCchr5

112043346

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000257435APCchr5

112043346

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000447165APCchr5

112043346

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000446294APCchr5

112043346

+NREPchr5

111071204

-
3UTR-3CDSENST00000505350ENST00000515855APCchr5

112043346

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000507742APCchr5

112043346

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000509979APCchr5

112043346

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000419114APCchr5

112043346

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000509427APCchr5

112043346

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000453526APCchr5

112043346

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000455559APCchr5

112043346

+NREPchr5

111071204

-
3UTR-5UTRENST00000505350ENST00000508870APCchr5

112043346

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000395634APCchr5

112043346

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000450761APCchr5

112043346

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000509025APCchr5

112043346

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000379671APCchr5

112043346

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000257435APCchr5

112043346

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000447165APCchr5

112043346

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000446294APCchr5

112043346

+NREPchr5

111071204

-
5UTR-3CDSENST00000457016ENST00000515855APCchr5

112043346

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000507742APCchr5

112043346

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000509979APCchr5

112043346

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000419114APCchr5

112043346

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000509427APCchr5

112043346

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000453526APCchr5

112043346

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000455559APCchr5

112043346

+NREPchr5

111071204

-
5UTR-5UTRENST00000457016ENST00000508870APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000395634APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000450761APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000509025APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000379671APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000257435APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000447165APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000446294APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000257430ENST00000515855APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000507742APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000509979APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000419114APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000509427APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000453526APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000455559APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000257430ENST00000508870APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000395634APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000450761APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000509025APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000379671APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000257435APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000447165APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000446294APCchr5

112043346

+NREPchr5

111071204

-
intron-3CDSENST00000508376ENST00000515855APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000507742APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000509979APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000419114APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000509427APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000453526APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000455559APCchr5

112043346

+NREPchr5

111071204

-
intron-5UTRENST00000508376ENST00000508870APCchr5

112043346

+NREPchr5

111071204

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for APC-NREP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for APC-NREP


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APC

P25054

NREP

Q16612

FUNCTION: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.FUNCTION: May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. {ECO:0000250, ECO:0000269|PubMed:11358844, ECO:0000269|PubMed:16229809}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for APC-NREP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for APC-NREP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APC-NREP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APC-NREP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPCC0032580Adenomatous Polyposis Coli24CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAPCC2713442Polyposis, Adenomatous Intestinal11CTD_human
HgeneAPCC2713443Familial Intestinal Polyposis11CTD_human
HgeneAPCC0007102Malignant tumor of colon7CTD_human
HgeneAPCC0009375Colonic Neoplasms7CTD_human
HgeneAPCC0009402Colorectal Carcinoma7CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAPCC0009404Colorectal Neoplasms7CTD_human;UNIPROT
HgeneAPCC0021841Intestinal Neoplasms6CTD_human
HgeneAPCC0346627Intestinal Cancer6CTD_human
HgeneAPCC0001430Adenoma5CTD_human
HgeneAPCC0205646Adenoma, Basal Cell5CTD_human
HgeneAPCC0205647Follicular adenoma5CTD_human
HgeneAPCC0205648Adenoma, Microcystic5CTD_human
HgeneAPCC0205649Adenoma, Monomorphic5CTD_human
HgeneAPCC0205650Papillary adenoma5CTD_human
HgeneAPCC0205651Adenoma, Trabecular5CTD_human
HgeneAPCC0021846Intestinal Polyps3CTD_human
HgeneAPCC0001418Adenocarcinoma2CTD_human
HgeneAPCC0004352Autistic Disorder2CTD_human
HgeneAPCC0007113Rectal Carcinoma2CTD_human
HgeneAPCC0007621Neoplastic Cell Transformation2CTD_human
HgeneAPCC0025149Medulloblastoma2CTD_human;UNIPROT
HgeneAPCC0033578Prostatic Neoplasms2CTD_human
HgeneAPCC0034885Rectal Neoplasms2CTD_human
HgeneAPCC0205641Adenocarcinoma, Basal Cell2CTD_human
HgeneAPCC0205642Adenocarcinoma, Oxyphilic2CTD_human
HgeneAPCC0205643Carcinoma, Cribriform2CTD_human
HgeneAPCC0205644Carcinoma, Granular Cell2CTD_human
HgeneAPCC0205645Adenocarcinoma, Tubular2CTD_human
HgeneAPCC0376358Malignant neoplasm of prostate2CTD_human
HgeneAPCC0002886Anemia, Macrocytic1CTD_human
HgeneAPCC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneAPCC0009405Hereditary Nonpolyposis Colorectal Neoplasms1CTD_human
HgeneAPCC0015393Eye Abnormalities1CTD_human
HgeneAPCC0017181Gastrointestinal Hemorrhage1CTD_human
HgeneAPCC0017185Gastrointestinal Neoplasms1CTD_human
HgeneAPCC0017636Glioblastoma1CTD_human
HgeneAPCC0018932Hematochezia1CTD_human
HgeneAPCC0020473Hyperlipidemia1CTD_human
HgeneAPCC0020796Profound Mental Retardation1CTD_human
HgeneAPCC0021390Inflammatory Bowel Diseases1CTD_human
HgeneAPCC0023518Leukocytosis1CTD_human
HgeneAPCC0023903Liver neoplasms1CTD_human
HgeneAPCC0024121Lung Neoplasms1CTD_human
HgeneAPCC0024667Animal Mammary Neoplasms1CTD_human
HgeneAPCC0025363Mental Retardation, Psychosocial1CTD_human
HgeneAPCC0025500Mesothelioma1CTD_human
HgeneAPCC0035222Respiratory Distress Syndrome, Adult1CTD_human
HgeneAPCC0036341Schizophrenia1PSYGENET
HgeneAPCC0038002Splenomegaly1CTD_human
HgeneAPCC0079218Fibromatosis, Aggressive1CGI;CTD_human;ORPHANET
HgeneAPCC0151857Pleocytosis1CTD_human
HgeneAPCC0205833Medullomyoblastoma1CTD_human
HgeneAPCC0206646Fibromatosis, Abdominal1CTD_human
HgeneAPCC0206677Adenomatous Polyps1CTD_human
HgeneAPCC0242379Malignant neoplasm of lung1CTD_human
HgeneAPCC0265325Turcot syndrome (disorder)1CTD_human
HgeneAPCC0278510Childhood Medulloblastoma1CTD_human
HgeneAPCC0278876Adult Medulloblastoma1CTD_human
HgeneAPCC0334588Giant Cell Glioblastoma1CTD_human
HgeneAPCC0345904Malignant neoplasm of liver1CTD_human
HgeneAPCC0685938Malignant neoplasm of gastrointestinal tract1CTD_human
HgeneAPCC0751291Desmoplastic Medulloblastoma1CTD_human
HgeneAPCC0917816Mental deficiency1CTD_human
HgeneAPCC1257925Mammary Carcinoma, Animal1CTD_human
HgeneAPCC1275668Melanotic medulloblastoma1CTD_human
HgeneAPCC1333990Hereditary Nonpolyposis Colorectal Cancer1CTD_human
HgeneAPCC1621958Glioblastoma Multiforme1CTD_human
HgeneAPCC1706412Lipidemias1CTD_human
HgeneAPCC1859309Syndactyly Cenani Lenz type1ORPHANET
HgeneAPCC1879526Aberrant Crypt Foci1CTD_human
HgeneAPCC3714756Intellectual Disability1CTD_human
HgeneAPCC4552100Lynch Syndrome1CTD_human
TgeneNREPC0015695Fatty Liver1CTD_human
TgeneNREPC0019193Hepatitis, Toxic1CTD_human
TgeneNREPC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNREPC0860207Drug-Induced Liver Disease1CTD_human
TgeneNREPC1262760Hepatitis, Drug-Induced1CTD_human
TgeneNREPC2711227Steatohepatitis1CTD_human
TgeneNREPC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneNREPC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneNREPC4279912Chemically-Induced Liver Toxicity1CTD_human