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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:MRRF-TTLL11 (FusionGDB2 ID:54911) |
Fusion Gene Summary for MRRF-TTLL11 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MRRF-TTLL11 | Fusion gene ID: 54911 | Hgene | Tgene | Gene symbol | MRRF | TTLL11 | Gene ID | 92399 | 158135 |
Gene name | mitochondrial ribosome recycling factor | tubulin tyrosine ligase like 11 | |
Synonyms | MRFF|MTRRF|RRF | C9orf20|bA244O19.1 | |
Cytomap | 9q33.2 | 9q33.2 | |
Type of gene | protein-coding | protein-coding | |
Description | ribosome-recycling factor, mitochondrialribosome-releasing factor, mitochondrial | tubulin polyglutamylase TTLL11tubulin tyrosine ligase like11tubulin tyrosine ligase-like family, member 11tubulin--tyrosine ligase-like protein 11 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000546115, ENST00000373730, ENST00000297908, ENST00000344641, ENST00000373723, ENST00000373729, ENST00000373724, ENST00000394315, | ENST00000321582, ENST00000474723, ENST00000373776, | |
Fusion gene scores | * DoF score | 6 X 4 X 6=144 | 9 X 6 X 7=378 |
# samples | 6 | 9 | |
** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MRRF [Title/Abstract] AND TTLL11 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MRRF(125054119)-TTLL11(124633027), # samples:4 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MRRF | GO:0032790 | ribosome disassembly | 19716793 |
Fusion gene breakpoints across MRRF (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across TTLL11 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | COAD | TCGA-DM-A28A-01A | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
ChimerDB4 | COAD | TCGA-DM-A28A | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
ChimerDB4 | COAD | TCGA-DM-A28A-01A | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
ChimerDB4 | COAD | TCGA-DM-A28A-01A | MRRF | chr9 | 125054119 | - | TTLL11 | chr9 | 124633027 | - |
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Fusion Gene ORF analysis for MRRF-TTLL11 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000546115 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
intron-5UTR | ENST00000546115 | ENST00000474723 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
intron-intron | ENST00000546115 | ENST00000373776 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
intron-3CDS | ENST00000373730 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
intron-5UTR | ENST00000373730 | ENST00000474723 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
intron-intron | ENST00000373730 | ENST00000373776 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
In-frame | ENST00000297908 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
5CDS-5UTR | ENST00000297908 | ENST00000474723 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
5CDS-intron | ENST00000297908 | ENST00000373776 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
In-frame | ENST00000344641 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
5CDS-5UTR | ENST00000344641 | ENST00000474723 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
5CDS-intron | ENST00000344641 | ENST00000373776 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
In-frame | ENST00000373723 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
5CDS-5UTR | ENST00000373723 | ENST00000474723 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
5CDS-intron | ENST00000373723 | ENST00000373776 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
In-frame | ENST00000373729 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
5CDS-5UTR | ENST00000373729 | ENST00000474723 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
5CDS-intron | ENST00000373729 | ENST00000373776 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
intron-3CDS | ENST00000373724 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
intron-5UTR | ENST00000373724 | ENST00000474723 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
intron-intron | ENST00000373724 | ENST00000373776 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
In-frame | ENST00000394315 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
5CDS-5UTR | ENST00000394315 | ENST00000474723 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
5CDS-intron | ENST00000394315 | ENST00000373776 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000297908 | MRRF | chr9 | 125054119 | + | ENST00000321582 | TTLL11 | chr9 | 124633027 | - | 2070 | 759 | 283 | 1410 | 375 |
ENST00000344641 | MRRF | chr9 | 125054119 | + | ENST00000321582 | TTLL11 | chr9 | 124633027 | - | 2173 | 862 | 230 | 1513 | 427 |
ENST00000373723 | MRRF | chr9 | 125054119 | + | ENST00000321582 | TTLL11 | chr9 | 124633027 | - | 1934 | 623 | 30 | 1274 | 414 |
ENST00000373729 | MRRF | chr9 | 125054119 | + | ENST00000321582 | TTLL11 | chr9 | 124633027 | - | 1836 | 525 | 64 | 1176 | 370 |
ENST00000394315 | MRRF | chr9 | 125054119 | + | ENST00000321582 | TTLL11 | chr9 | 124633027 | - | 1890 | 579 | 16 | 1230 | 404 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000297908 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - | 0.03876443 | 0.9612356 |
ENST00000344641 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - | 0.013571313 | 0.9864287 |
ENST00000373723 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - | 0.009299344 | 0.9907006 |
ENST00000373729 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - | 0.003630334 | 0.9963697 |
ENST00000394315 | ENST00000321582 | MRRF | chr9 | 125054119 | + | TTLL11 | chr9 | 124633027 | - | 0.00983721 | 0.99016285 |
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Fusion Genomic Features for MRRF-TTLL11 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MRRF-TTLL11 |
Go to FGviewer for the breakpoints of chr9:125054119-chr9:124633027 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | TTLL11 | chr9:125054119 | chr9:124633027 | ENST00000373776 | 0 | 4 | 218_570 | 0 | 539.0 | Domain | TTL | |
Tgene | TTLL11 | chr9:125054119 | chr9:124633027 | ENST00000373776 | 0 | 4 | 372_375 | 0 | 539.0 | Nucleotide binding | ATP binding | |
Tgene | TTLL11 | chr9:125054119 | chr9:124633027 | ENST00000373776 | 0 | 4 | 557_628 | 0 | 539.0 | Region | c-MTBD region |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MRRF-TTLL11 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000297908_ENST00000321582_TCGA-DM-A28A-01A_MRRF_chr9_125054119_+_TTLL11_chr9_124633027_length(transcript)=2070nt_BP=759nt ACAGGACAATCCGGGGCGGGGCCTGAGATGCAGTCCTGCGAGGGCGGCCTCCTGTAAGACCTCTTAGCGGGCCCATCGCTGAGGTGCAGG GACATGTCGCGGCCGAACTCACCTCGTGGCCTCGGCGTGGTGCTCTCAGCTCATGCCCGGAAACCAGGTCCCGACGCCGCGGTCAGACGG ACCTCTAGACGCGTCCGCCTCAATGCCGCCAGCTGCCAGGCCGCCCGTGACGCGTTAAGCCTGCGCCGCCTCCTGGCTTCGTGACGTCAC GACGTCCGCGCAGCTGCGGTCGCCGCCGTCGCACGAGTCTTTCCTTAGTAACCTGGGCGATAGCTGTGGATGTTTCCAAGGATTGTCTTC AGTCATGGCCTTGGGATTAAAGTGCTTCCGCATGGTCCACCCTACCTTTCGCAATTATCTTGCAGCCTCTATCAGACCCGTTTCAGAAGT TACACTGAAGACAGTGCATGAAAGACAACATGGCCATAGGCAATACATGGCCTATTCAGCTGTACCAGTCCGCCATTTTGCTACCAAGAA AGCCAAAGGATCCCTTGACAAGATTGCTGTGGTAACTGCTGACGGGAAGCTTGCTTTAAACCAGATTAGCCAGATCTCCATGAAGTCGCC ACAGCTGATTTTGGTGAATATGGCCAGCTTCCCAGAGTGTACAGCTGCAGCTATCAAGGCTATAAGAGAAAGTGGAATGAATCTGAACCC AGAAGTGGAAGGGACGCTAATTCGGGTACCCATTCCCCAGTCTCAGCAGCTTGAAAAACCATTCGCTGGAAAGGAAGATGCTTTGGACGG CGAGCTGACCAGTGCTCCAGACTGCAACGCCAACCCCGAAGCCCACCTGCCTTCCATTTGCCTCAAGCAGGTGTTCCCCAAGTACGCAAA ACAGTTCAACTACCTGCGCCTGGTGGACAGGATGGCAAATTTGTTTATCCGGTTCCTGGGCATCAAGGGGACAATGAAGTTGGGGCCAAC AGGCTTTCGTACCTTCATAAGGAGCTGCAAACTCAGCAGCAGCAGCCTGTCCATGGCTGCCGTGGACATCCTCTACATTGACATCACACG GAGGTGGAACTCCATGACCCTGGACCAGCGGGACTCAGGGATGTGTCTGCAGGCCTTCGTAGAAGCTTTCTTTTTCCTGGCTCAGAGGAA GTTCAAGATGCTGCCACTTCATGAGCAGGTGGCCTCACTGATTGACCTTTGCGAGTACCACCTGTCCCTGCTGGATGAAAAACGCCTGGT GTGTGGCCGGGGCGTCCCGTCGGGGGGCCGGCCCCCACACCGTGGCCCTCCCCAGGAGCCCTCCCCCTCGGCCCAGCCAGCAGGGGACAA CCCCCCACCCCGCACCAGCTGTGCCAATAAGCTCTCCCATCCCAGACATACCCTGTCCTGAGGGCCACTCTGTCCTCCTGGAAAACGGAA GACGAGAGCAGCTTTCAGGGCTGGAGCGCCCCAGGCATTCTGCCTGCAGAGGAATGGCAGGCAGGCTGCCGAGGGGCCCAGCTGAGGTCC CCACGAACTGTCTCTGTGTGCGGCTGAGCTGTGCTTCACCAGGCTGGCTGGTTCTCACCTGCCTTCCTCCTCACACCTCCTGGTGATACA CCCTGTTTCTGAGTCATCAGTCATCGGACATATGACATCTAAAACGTGACAGATGGCACCTTCTATTCTGGGCTCACAGGAAGCACCAAC TGGGGCAAATCTGTTGTATTTGGGGCACAGGACACAATCGATCCCAAGGCCCGGAGCTGTGGAGAGGAAGCCGAGTGTTAGGATCTGCTG CCGGGGCCTCCACGCGCCCACCGGGAAAAGCCTGAGAACATCGTGTTTATTTCCTGCCGCCCGTTCCGAGAGAAGGAAGTGGAAATATCA AGTAGGCATCTGCGAATCTCCCATCCCAGTCATGTGCTACATGGGTGTAGTGAACAGATTAACCTCATTTAGTTCATTAGCTTGCCTGTT GCTGCAATATTTGGTTTGTTATTAATTAAGAAAAAATTAATTAAGAAGTAACTAAGACTCCTGGAGCCTCAGAGCTGGCAGGAGCCTCAG >In-frame_ENST00000297908_ENST00000321582_TCGA-DM-A28A-01A_MRRF_chr9_125054119_+_TTLL11_chr9_124633027_length(amino acids)=375AA_start in transcript=283_stop in transcript=1410 MRSPPSHESFLSNLGDSCGCFQGLSSVMALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKAKGS LDKIAVVTADGKLALNQISQISMKSPQLILVNMASFPECTAAAIKAIRESGMNLNPEVEGTLIRVPIPQSQQLEKPFAGKEDALDGELTS APDCNANPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRSCKLSSSSLSMAAVDILYIDITRRWNS MTLDQRDSGMCLQAFVEAFFFLAQRKFKMLPLHEQVASLIDLCEYHLSLLDEKRLVCGRGVPSGGRPPHRGPPQEPSPSAQPAGDNPPPR -------------------------------------------------------------- >In-frame_ENST00000344641_ENST00000321582_TCGA-DM-A28A-01A_MRRF_chr9_125054119_+_TTLL11_chr9_124633027_length(transcript)=2173nt_BP=862nt GTAAGACCTCTTAGCGGGCCCATCGCTGAGGTGCAGGGACATGTCGCGGCCGAACTCACCTCGTGGCCTCGGCGTGGTGCTCTCAGCTCA TGCCCGGAAACCAGGTCCCGACGCCGCGGTCAGACGGACCTCTAGACGCGTCCGCCTCAATGCCGCCAGCTGCCAGGCCGCCCGTGACGC GTTAAGCCTGCGCCGCCTCCTGGCTTCGTGACGTCACGACGTCCGCGCAGCTGCGGTCGCCGCCGTCGCACGAGTCTTTCCTTAGTAACC TGGGCGATAGCTGTGGATGTTTCCAAGGATTGTCTTCAGTCATGGCCTTGGGATTAAAGTGCTTCCGCATGGTCCACCCTACCTTTCGCA ATTATCTTGCAGCCTCTATCAGACCCGTTTCAGAAGTTACACTGAAGACAGTGCATGAAAGACAACATGGCCATAGGCAATACATGGCCT ATTCAGCTGTACCAGTCCGCCATTTTGCTACCAAGAAAGCCAAAGCCAAAGGGAAAGGACAGTCCCAAACCAGAGTGAATATTAATGCTG CCTTGGTTGAGGATATAATCAACTTGGAAGAGGTGAATGAAGAAATGAAGTCTGTGATAGAAGCTCTCAAGGATAATTTCAATAAGACTC TCAATATAAGGACCTCACCAGGATCCCTTGACAAGATTGCTGTGGTAACTGCTGACGGGAAGCTTGCTTTAAACCAGATTAGCCAGATCT CCATGAAGTCGCCACAGCTGATTTTGGTGAATATGGCCAGCTTCCCAGAGTGTACAGCTGCAGCTATCAAGGCTATAAGAGAAAGTGGAA TGAATCTGAACCCAGAAGTGGAAGGGACGCTAATTCGGGTACCCATTCCCCAGTCTCAGCAGCTTGAAAAACCATTCGCTGGAAAGGAAG ATGCTTTGGACGGCGAGCTGACCAGTGCTCCAGACTGCAACGCCAACCCCGAAGCCCACCTGCCTTCCATTTGCCTCAAGCAGGTGTTCC CCAAGTACGCAAAACAGTTCAACTACCTGCGCCTGGTGGACAGGATGGCAAATTTGTTTATCCGGTTCCTGGGCATCAAGGGGACAATGA AGTTGGGGCCAACAGGCTTTCGTACCTTCATAAGGAGCTGCAAACTCAGCAGCAGCAGCCTGTCCATGGCTGCCGTGGACATCCTCTACA TTGACATCACACGGAGGTGGAACTCCATGACCCTGGACCAGCGGGACTCAGGGATGTGTCTGCAGGCCTTCGTAGAAGCTTTCTTTTTCC TGGCTCAGAGGAAGTTCAAGATGCTGCCACTTCATGAGCAGGTGGCCTCACTGATTGACCTTTGCGAGTACCACCTGTCCCTGCTGGATG AAAAACGCCTGGTGTGTGGCCGGGGCGTCCCGTCGGGGGGCCGGCCCCCACACCGTGGCCCTCCCCAGGAGCCCTCCCCCTCGGCCCAGC CAGCAGGGGACAACCCCCCACCCCGCACCAGCTGTGCCAATAAGCTCTCCCATCCCAGACATACCCTGTCCTGAGGGCCACTCTGTCCTC CTGGAAAACGGAAGACGAGAGCAGCTTTCAGGGCTGGAGCGCCCCAGGCATTCTGCCTGCAGAGGAATGGCAGGCAGGCTGCCGAGGGGC CCAGCTGAGGTCCCCACGAACTGTCTCTGTGTGCGGCTGAGCTGTGCTTCACCAGGCTGGCTGGTTCTCACCTGCCTTCCTCCTCACACC TCCTGGTGATACACCCTGTTTCTGAGTCATCAGTCATCGGACATATGACATCTAAAACGTGACAGATGGCACCTTCTATTCTGGGCTCAC AGGAAGCACCAACTGGGGCAAATCTGTTGTATTTGGGGCACAGGACACAATCGATCCCAAGGCCCGGAGCTGTGGAGAGGAAGCCGAGTG TTAGGATCTGCTGCCGGGGCCTCCACGCGCCCACCGGGAAAAGCCTGAGAACATCGTGTTTATTTCCTGCCGCCCGTTCCGAGAGAAGGA AGTGGAAATATCAAGTAGGCATCTGCGAATCTCCCATCCCAGTCATGTGCTACATGGGTGTAGTGAACAGATTAACCTCATTTAGTTCAT TAGCTTGCCTGTTGCTGCAATATTTGGTTTGTTATTAATTAAGAAAAAATTAATTAAGAAGTAACTAAGACTCCTGGAGCCTCAGAGCTG >In-frame_ENST00000344641_ENST00000321582_TCGA-DM-A28A-01A_MRRF_chr9_125054119_+_TTLL11_chr9_124633027_length(amino acids)=427AA_start in transcript=230_stop in transcript=1513 MRSPPSHESFLSNLGDSCGCFQGLSSVMALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKAKAK GKGQSQTRVNINAALVEDIINLEEVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIAVVTADGKLALNQISQISMKSPQLILVNMASFPE CTAAAIKAIRESGMNLNPEVEGTLIRVPIPQSQQLEKPFAGKEDALDGELTSAPDCNANPEAHLPSICLKQVFPKYAKQFNYLRLVDRMA NLFIRFLGIKGTMKLGPTGFRTFIRSCKLSSSSLSMAAVDILYIDITRRWNSMTLDQRDSGMCLQAFVEAFFFLAQRKFKMLPLHEQVAS -------------------------------------------------------------- >In-frame_ENST00000373723_ENST00000321582_TCGA-DM-A28A-01A_MRRF_chr9_125054119_+_TTLL11_chr9_124633027_length(transcript)=1934nt_BP=623nt CCGCCGTCGCACGAGTCTTTCCTTAGTAACCTGGGCGATAGCTGTGGATGTTTCCAAGGATTGTCTTCAGTCATGGCCTTGGGATTAAAG TGCTTCCGCATGGTCCACCCTACCTTTCGCAATTATCTTGCAGCCTCTATCAGACCCGTTTCAGAAGTTACACTGAAGACAGTGCATGAA AGACAACATGGCCATAGGCAATACATGGCCTATTCAGCTGTACCAGTCCGCCATTTTGCTACCAAGAAAGCCAAAGCCAAAGGGAAAGGA CAGTCCCAAACCAGAGTGAATATTAATGCTGCCTTGGTTGAGGATATAATCAACTTGGAAGAGGTGAATGAAGAAATGAAGTCTGTGATA GAAGCTCTCAAGGATAATTTCAATAAGACTCTCAATATAAGGACCTCACCAGGATCCCTTGACAAGATTGCTGTGGTAACTGCTGACGGG AAGCTTGCTTTAAACCAGATTAGCCAGATCTCCATGAAGTCGCCACAGCTGATTTTGGTGAATATGGCCAGCTTCCCAGAGTGTACAGCT GCAGCTATCAAGGCTATAAGAGAAAGTGGAATGAATCTGAACCCAGAAGTGGAAGGGACGCTAATTCGGGTACCCATTCCCCAGTCTCAG CAGCTTGAAAAACCATTCGCTGGAAAGGAAGATGCTTTGGACGGCGAGCTGACCAGTGCTCCAGACTGCAACGCCAACCCCGAAGCCCAC CTGCCTTCCATTTGCCTCAAGCAGGTGTTCCCCAAGTACGCAAAACAGTTCAACTACCTGCGCCTGGTGGACAGGATGGCAAATTTGTTT ATCCGGTTCCTGGGCATCAAGGGGACAATGAAGTTGGGGCCAACAGGCTTTCGTACCTTCATAAGGAGCTGCAAACTCAGCAGCAGCAGC CTGTCCATGGCTGCCGTGGACATCCTCTACATTGACATCACACGGAGGTGGAACTCCATGACCCTGGACCAGCGGGACTCAGGGATGTGT CTGCAGGCCTTCGTAGAAGCTTTCTTTTTCCTGGCTCAGAGGAAGTTCAAGATGCTGCCACTTCATGAGCAGGTGGCCTCACTGATTGAC CTTTGCGAGTACCACCTGTCCCTGCTGGATGAAAAACGCCTGGTGTGTGGCCGGGGCGTCCCGTCGGGGGGCCGGCCCCCACACCGTGGC CCTCCCCAGGAGCCCTCCCCCTCGGCCCAGCCAGCAGGGGACAACCCCCCACCCCGCACCAGCTGTGCCAATAAGCTCTCCCATCCCAGA CATACCCTGTCCTGAGGGCCACTCTGTCCTCCTGGAAAACGGAAGACGAGAGCAGCTTTCAGGGCTGGAGCGCCCCAGGCATTCTGCCTG CAGAGGAATGGCAGGCAGGCTGCCGAGGGGCCCAGCTGAGGTCCCCACGAACTGTCTCTGTGTGCGGCTGAGCTGTGCTTCACCAGGCTG GCTGGTTCTCACCTGCCTTCCTCCTCACACCTCCTGGTGATACACCCTGTTTCTGAGTCATCAGTCATCGGACATATGACATCTAAAACG TGACAGATGGCACCTTCTATTCTGGGCTCACAGGAAGCACCAACTGGGGCAAATCTGTTGTATTTGGGGCACAGGACACAATCGATCCCA AGGCCCGGAGCTGTGGAGAGGAAGCCGAGTGTTAGGATCTGCTGCCGGGGCCTCCACGCGCCCACCGGGAAAAGCCTGAGAACATCGTGT TTATTTCCTGCCGCCCGTTCCGAGAGAAGGAAGTGGAAATATCAAGTAGGCATCTGCGAATCTCCCATCCCAGTCATGTGCTACATGGGT GTAGTGAACAGATTAACCTCATTTAGTTCATTAGCTTGCCTGTTGCTGCAATATTTGGTTTGTTATTAATTAAGAAAAAATTAATTAAGA >In-frame_ENST00000373723_ENST00000321582_TCGA-DM-A28A-01A_MRRF_chr9_125054119_+_TTLL11_chr9_124633027_length(amino acids)=414AA_start in transcript=30_stop in transcript=1274 MGDSCGCFQGLSSVMALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKAKAKGKGQSQTRVNINA ALVEDIINLEEVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIAVVTADGKLALNQISQISMKSPQLILVNMASFPECTAAAIKAIRESG MNLNPEVEGTLIRVPIPQSQQLEKPFAGKEDALDGELTSAPDCNANPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTM KLGPTGFRTFIRSCKLSSSSLSMAAVDILYIDITRRWNSMTLDQRDSGMCLQAFVEAFFFLAQRKFKMLPLHEQVASLIDLCEYHLSLLD -------------------------------------------------------------- >In-frame_ENST00000373729_ENST00000321582_TCGA-DM-A28A-01A_MRRF_chr9_125054119_+_TTLL11_chr9_124633027_length(transcript)=1836nt_BP=525nt CACGAGTCTTTCCTTAGTAACCTGGGCGATAGCTGCCTCTATCAGACCCGTTTCAGAAGTTACACTGAAGACAGTGCATGAAAGACAACA TGGCCATAGGCAATACATGGCCTATTCAGCTGTACCAGTCCGCCATTTTGCTACCAAGAAAGCCAAAGCCAAAGGGAAAGGACAGTCCCA AACCAGAGTGAATATTAATGCTGCCTTGGTTGAGGATATAATCAACTTGGAAGAGGTGAATGAAGAAATGAAGTCTGTGATAGAAGCTCT CAAGGATAATTTCAATAAGACTCTCAATATAAGGACCTCACCAGGATCCCTTGACAAGATTGCTGTGGTAACTGCTGACGGGAAGCTTGC TTTAAACCAGATTAGCCAGATCTCCATGAAGTCGCCACAGCTGATTTTGGTGAATATGGCCAGCTTCCCAGAGTGTACAGCTGCAGCTAT CAAGGCTATAAGAGAAAGTGGAATGAATCTGAACCCAGAAGTGGAAGGGACGCTAATTCGGGTACCCATTCCCCAGTCTCAGCAGCTTGA AAAACCATTCGCTGGAAAGGAAGATGCTTTGGACGGCGAGCTGACCAGTGCTCCAGACTGCAACGCCAACCCCGAAGCCCACCTGCCTTC CATTTGCCTCAAGCAGGTGTTCCCCAAGTACGCAAAACAGTTCAACTACCTGCGCCTGGTGGACAGGATGGCAAATTTGTTTATCCGGTT CCTGGGCATCAAGGGGACAATGAAGTTGGGGCCAACAGGCTTTCGTACCTTCATAAGGAGCTGCAAACTCAGCAGCAGCAGCCTGTCCAT GGCTGCCGTGGACATCCTCTACATTGACATCACACGGAGGTGGAACTCCATGACCCTGGACCAGCGGGACTCAGGGATGTGTCTGCAGGC CTTCGTAGAAGCTTTCTTTTTCCTGGCTCAGAGGAAGTTCAAGATGCTGCCACTTCATGAGCAGGTGGCCTCACTGATTGACCTTTGCGA GTACCACCTGTCCCTGCTGGATGAAAAACGCCTGGTGTGTGGCCGGGGCGTCCCGTCGGGGGGCCGGCCCCCACACCGTGGCCCTCCCCA GGAGCCCTCCCCCTCGGCCCAGCCAGCAGGGGACAACCCCCCACCCCGCACCAGCTGTGCCAATAAGCTCTCCCATCCCAGACATACCCT GTCCTGAGGGCCACTCTGTCCTCCTGGAAAACGGAAGACGAGAGCAGCTTTCAGGGCTGGAGCGCCCCAGGCATTCTGCCTGCAGAGGAA TGGCAGGCAGGCTGCCGAGGGGCCCAGCTGAGGTCCCCACGAACTGTCTCTGTGTGCGGCTGAGCTGTGCTTCACCAGGCTGGCTGGTTC TCACCTGCCTTCCTCCTCACACCTCCTGGTGATACACCCTGTTTCTGAGTCATCAGTCATCGGACATATGACATCTAAAACGTGACAGAT GGCACCTTCTATTCTGGGCTCACAGGAAGCACCAACTGGGGCAAATCTGTTGTATTTGGGGCACAGGACACAATCGATCCCAAGGCCCGG AGCTGTGGAGAGGAAGCCGAGTGTTAGGATCTGCTGCCGGGGCCTCCACGCGCCCACCGGGAAAAGCCTGAGAACATCGTGTTTATTTCC TGCCGCCCGTTCCGAGAGAAGGAAGTGGAAATATCAAGTAGGCATCTGCGAATCTCCCATCCCAGTCATGTGCTACATGGGTGTAGTGAA CAGATTAACCTCATTTAGTTCATTAGCTTGCCTGTTGCTGCAATATTTGGTTTGTTATTAATTAAGAAAAAATTAATTAAGAAGTAACTA >In-frame_ENST00000373729_ENST00000321582_TCGA-DM-A28A-01A_MRRF_chr9_125054119_+_TTLL11_chr9_124633027_length(amino acids)=370AA_start in transcript=64_stop in transcript=1176 MKTVHERQHGHRQYMAYSAVPVRHFATKKAKAKGKGQSQTRVNINAALVEDIINLEEVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIA VVTADGKLALNQISQISMKSPQLILVNMASFPECTAAAIKAIRESGMNLNPEVEGTLIRVPIPQSQQLEKPFAGKEDALDGELTSAPDCN ANPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRSCKLSSSSLSMAAVDILYIDITRRWNSMTLDQ RDSGMCLQAFVEAFFFLAQRKFKMLPLHEQVASLIDLCEYHLSLLDEKRLVCGRGVPSGGRPPHRGPPQEPSPSAQPAGDNPPPRTSCAN -------------------------------------------------------------- >In-frame_ENST00000394315_ENST00000321582_TCGA-DM-A28A-01A_MRRF_chr9_125054119_+_TTLL11_chr9_124633027_length(transcript)=1890nt_BP=579nt TGGATGTTTCCAAGGATTGTCTTCAGTCATGGCCTTGGGATTAAAGTGCTTCCGCATGGTCCACCCTACCTTTCGCAATTATCTTGCAGC CTCTATCAGACCCGTTTCAGAAGTTACACTGAAGACAGTGCATGAAAGACAACATGGCCATAGGCAATACATGGCCTATTCAGCTGTACC AGTCCGCCATTTTGCTACCAAGAAAGCCAAAGCCAAAGGGAAAGGACAGTCCCAAACCAGAGTGAATATTAATGCTGCCTTGGTTGAGGA TATAATCAACTTGGAAGAGGTGAATGAAGAAATGAAGTCTGTGATAGAAGCTCTCAAGGATAATTTCAATAAGACTCTCAATATAAGGAC CTCACCAGGATCCCTTGACAAGATTGCTGTGGTAACTGCTGACGGGAAGCTTGCTTTAAACCAGATTAGCCAGATCTCCATGAAGTCGCC ACAGCTGATTTTGGTGAATATGGCCAGCTTCCCAGAGTGTACAGCTGCAGCTATCAAGGCTATAAGAGAAAGTGGAATGAATCTGAACCC AGAAGTGGAAGGGACGCTAATTCGGGTACCCATTCCCCAGTCTCAGCAGCTTGAAAAACCATTCGCTGGAAAGGAAGATGCTTTGGACGG CGAGCTGACCAGTGCTCCAGACTGCAACGCCAACCCCGAAGCCCACCTGCCTTCCATTTGCCTCAAGCAGGTGTTCCCCAAGTACGCAAA ACAGTTCAACTACCTGCGCCTGGTGGACAGGATGGCAAATTTGTTTATCCGGTTCCTGGGCATCAAGGGGACAATGAAGTTGGGGCCAAC AGGCTTTCGTACCTTCATAAGGAGCTGCAAACTCAGCAGCAGCAGCCTGTCCATGGCTGCCGTGGACATCCTCTACATTGACATCACACG GAGGTGGAACTCCATGACCCTGGACCAGCGGGACTCAGGGATGTGTCTGCAGGCCTTCGTAGAAGCTTTCTTTTTCCTGGCTCAGAGGAA GTTCAAGATGCTGCCACTTCATGAGCAGGTGGCCTCACTGATTGACCTTTGCGAGTACCACCTGTCCCTGCTGGATGAAAAACGCCTGGT GTGTGGCCGGGGCGTCCCGTCGGGGGGCCGGCCCCCACACCGTGGCCCTCCCCAGGAGCCCTCCCCCTCGGCCCAGCCAGCAGGGGACAA CCCCCCACCCCGCACCAGCTGTGCCAATAAGCTCTCCCATCCCAGACATACCCTGTCCTGAGGGCCACTCTGTCCTCCTGGAAAACGGAA GACGAGAGCAGCTTTCAGGGCTGGAGCGCCCCAGGCATTCTGCCTGCAGAGGAATGGCAGGCAGGCTGCCGAGGGGCCCAGCTGAGGTCC CCACGAACTGTCTCTGTGTGCGGCTGAGCTGTGCTTCACCAGGCTGGCTGGTTCTCACCTGCCTTCCTCCTCACACCTCCTGGTGATACA CCCTGTTTCTGAGTCATCAGTCATCGGACATATGACATCTAAAACGTGACAGATGGCACCTTCTATTCTGGGCTCACAGGAAGCACCAAC TGGGGCAAATCTGTTGTATTTGGGGCACAGGACACAATCGATCCCAAGGCCCGGAGCTGTGGAGAGGAAGCCGAGTGTTAGGATCTGCTG CCGGGGCCTCCACGCGCCCACCGGGAAAAGCCTGAGAACATCGTGTTTATTTCCTGCCGCCCGTTCCGAGAGAAGGAAGTGGAAATATCA AGTAGGCATCTGCGAATCTCCCATCCCAGTCATGTGCTACATGGGTGTAGTGAACAGATTAACCTCATTTAGTTCATTAGCTTGCCTGTT GCTGCAATATTTGGTTTGTTATTAATTAAGAAAAAATTAATTAAGAAGTAACTAAGACTCCTGGAGCCTCAGAGCTGGCAGGAGCCTCAG >In-frame_ENST00000394315_ENST00000321582_TCGA-DM-A28A-01A_MRRF_chr9_125054119_+_TTLL11_chr9_124633027_length(amino acids)=404AA_start in transcript=16_stop in transcript=1230 MSSVMALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKAKAKGKGQSQTRVNINAALVEDIINLE EVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIAVVTADGKLALNQISQISMKSPQLILVNMASFPECTAAAIKAIRESGMNLNPEVEGT LIRVPIPQSQQLEKPFAGKEDALDGELTSAPDCNANPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTF IRSCKLSSSSLSMAAVDILYIDITRRWNSMTLDQRDSGMCLQAFVEAFFFLAQRKFKMLPLHEQVASLIDLCEYHLSLLDEKRLVCGRGV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MRRF-TTLL11 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MRRF-TTLL11 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MRRF-TTLL11 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |