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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:MSH2-M1AP (FusionGDB2 ID:54943) |
Fusion Gene Summary for MSH2-M1AP |
Fusion gene summary |
Fusion gene information | Fusion gene name: MSH2-M1AP | Fusion gene ID: 54943 | Hgene | Tgene | Gene symbol | MSH2 | M1AP | Gene ID | 4436 | 130951 |
Gene name | mutS homolog 2 | meiosis 1 associated protein | |
Synonyms | COCA1|FCC1|HNPCC|HNPCC1|LCFS2|hMSH2 | C2orf65|D6Mm5e|SPATA37 | |
Cytomap | 2p21-p16.3 | 2p13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA mismatch repair protein Msh2DNA mismatch repair protein Msh2 transcriptmutS homolog 2, colon cancer, nonpolyposis type 1 | meiosis 1 arrest proteinmeiosis 1 arresting proteinspermatogenesis associated 37 | |
Modification date | 20200322 | 20200320 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000233146, ENST00000543555, ENST00000406134, ENST00000461394, | ENST00000290536, ENST00000409585, ENST00000536235, ENST00000358434, ENST00000464686, | |
Fusion gene scores | * DoF score | 15 X 12 X 10=1800 | 6 X 6 X 5=180 |
# samples | 23 | 7 | |
** MAII score | log2(23/1800*10)=-2.96829114027266 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MSH2 [Title/Abstract] AND M1AP [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MSH2(47672796)-M1AP(74787418), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MSH2 | GO:0006281 | DNA repair | 8942985 |
Hgene | MSH2 | GO:0006298 | mismatch repair | 7923193|11555625 |
Hgene | MSH2 | GO:0006301 | postreplication repair | 7923193 |
Hgene | MSH2 | GO:0045910 | negative regulation of DNA recombination | 17715146 |
Hgene | MSH2 | GO:0051096 | positive regulation of helicase activity | 17715146 |
Fusion gene breakpoints across MSH2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across M1AP (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | UCEC | TCGA-AJ-A23M-01A | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
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Fusion Gene ORF analysis for MSH2-M1AP |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000233146 | ENST00000290536 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
In-frame | ENST00000233146 | ENST00000409585 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
In-frame | ENST00000233146 | ENST00000536235 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
In-frame | ENST00000233146 | ENST00000358434 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
5CDS-5UTR | ENST00000233146 | ENST00000464686 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
In-frame | ENST00000543555 | ENST00000290536 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
In-frame | ENST00000543555 | ENST00000409585 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
In-frame | ENST00000543555 | ENST00000536235 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
In-frame | ENST00000543555 | ENST00000358434 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
5CDS-5UTR | ENST00000543555 | ENST00000464686 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
In-frame | ENST00000406134 | ENST00000290536 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
In-frame | ENST00000406134 | ENST00000409585 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
In-frame | ENST00000406134 | ENST00000536235 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
In-frame | ENST00000406134 | ENST00000358434 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
5CDS-5UTR | ENST00000406134 | ENST00000464686 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
intron-3CDS | ENST00000461394 | ENST00000290536 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
intron-3CDS | ENST00000461394 | ENST00000409585 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
intron-3CDS | ENST00000461394 | ENST00000536235 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
intron-3CDS | ENST00000461394 | ENST00000358434 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
intron-5UTR | ENST00000461394 | ENST00000464686 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000233146 | MSH2 | chr2 | 47672796 | + | ENST00000290536 | M1AP | chr2 | 74787418 | - | 2754 | 1609 | 223 | 1920 | 565 |
ENST00000233146 | MSH2 | chr2 | 47672796 | + | ENST00000409585 | M1AP | chr2 | 74787418 | - | 2733 | 1609 | 223 | 1908 | 561 |
ENST00000233146 | MSH2 | chr2 | 47672796 | + | ENST00000536235 | M1AP | chr2 | 74787418 | - | 2287 | 1609 | 223 | 1908 | 561 |
ENST00000233146 | MSH2 | chr2 | 47672796 | + | ENST00000358434 | M1AP | chr2 | 74787418 | - | 1921 | 1609 | 223 | 1920 | 566 |
ENST00000543555 | MSH2 | chr2 | 47672796 | + | ENST00000290536 | M1AP | chr2 | 74787418 | - | 2472 | 1327 | 7 | 1638 | 543 |
ENST00000543555 | MSH2 | chr2 | 47672796 | + | ENST00000409585 | M1AP | chr2 | 74787418 | - | 2451 | 1327 | 7 | 1626 | 539 |
ENST00000543555 | MSH2 | chr2 | 47672796 | + | ENST00000536235 | M1AP | chr2 | 74787418 | - | 2005 | 1327 | 7 | 1626 | 539 |
ENST00000543555 | MSH2 | chr2 | 47672796 | + | ENST00000358434 | M1AP | chr2 | 74787418 | - | 1639 | 1327 | 7 | 1638 | 544 |
ENST00000406134 | MSH2 | chr2 | 47672796 | + | ENST00000290536 | M1AP | chr2 | 74787418 | - | 2593 | 1448 | 62 | 1759 | 565 |
ENST00000406134 | MSH2 | chr2 | 47672796 | + | ENST00000409585 | M1AP | chr2 | 74787418 | - | 2572 | 1448 | 62 | 1747 | 561 |
ENST00000406134 | MSH2 | chr2 | 47672796 | + | ENST00000536235 | M1AP | chr2 | 74787418 | - | 2126 | 1448 | 62 | 1747 | 561 |
ENST00000406134 | MSH2 | chr2 | 47672796 | + | ENST00000358434 | M1AP | chr2 | 74787418 | - | 1760 | 1448 | 62 | 1759 | 566 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000233146 | ENST00000290536 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.001630987 | 0.99836904 |
ENST00000233146 | ENST00000409585 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.001611827 | 0.9983882 |
ENST00000233146 | ENST00000536235 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.002606605 | 0.99739337 |
ENST00000233146 | ENST00000358434 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.0032819 | 0.9967181 |
ENST00000543555 | ENST00000290536 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.001091435 | 0.9989085 |
ENST00000543555 | ENST00000409585 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.001012516 | 0.9989875 |
ENST00000543555 | ENST00000536235 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.001296486 | 0.9987035 |
ENST00000543555 | ENST00000358434 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.001710473 | 0.9982895 |
ENST00000406134 | ENST00000290536 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.00154556 | 0.99845445 |
ENST00000406134 | ENST00000409585 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.001541565 | 0.9984584 |
ENST00000406134 | ENST00000536235 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.0022651 | 0.9977349 |
ENST00000406134 | ENST00000358434 | MSH2 | chr2 | 47672796 | + | M1AP | chr2 | 74787418 | - | 0.002970646 | 0.9970293 |
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Fusion Genomic Features for MSH2-M1AP |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MSH2-M1AP |
Go to FGviewer for the breakpoints of chr2:47672796-chr2:74787418 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MSH2 | chr2:47672796 | chr2:74787418 | ENST00000233146 | + | 8 | 16 | 669_676 | 462.0 | 935.0 | Nucleotide binding | ATP |
Hgene | MSH2 | chr2:47672796 | chr2:74787418 | ENST00000543555 | + | 9 | 17 | 669_676 | 396.0 | 869.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for MSH2-M1AP |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000233146_ENST00000290536_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=2754nt_BP=1609nt GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGA AAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGC TGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTT TGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTC TGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGAT TAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTT ACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCG ACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTT TGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGA CAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGG GCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGT GGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTC AGAGTGGGAGAAGGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATA ATGGCTATCTGTGGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTT CAGTGCTGTCCCACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTG CTACTGTTTACACAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCT GTGTAAGCAGGTGGATGAGGTCAGATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAAAGCTCATAAAAGACAAGTA AGATTGAAATCCAAGCCTCATTTCAGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAGAGACAAGTGCTTGGTACCT ACATGCAAAGTGTGTGTGCTGGGGGGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGACCTACTCCTTTCCTGTTAC CCTCTCCCCACATGTACCAACCTTCCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAATGTTTACTCTGGGCTGGGAG CAGTGGCTCACACCTGTAATCCCAACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTGAGCAACA >In-frame_ENST00000233146_ENST00000290536_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=565AA_start in transcript=223_stop in transcript=1920 MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASK -------------------------------------------------------------- >In-frame_ENST00000233146_ENST00000409585_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=2733nt_BP=1609nt GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGA AAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGC TGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTT TGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTC TGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGAT TAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTT ACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCG ACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTT TGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGA CAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGG GCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCC TATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAA GGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATAATGGCTATCTGT GGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTTCAGTGCTGTCCC ACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTGCTACTGTTTACA CAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCTGTGTAAGCAGGT GGATGAGGTCAGATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAAAGCTCATAAAAGACAAGTAAGATTGAAATCC AAGCCTCATTTCAGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAGAGACAAGTGCTTGGTACCTACATGCAAAGTG TGTGTGCTGGGGGGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGACCTACTCCTTTCCTGTTACCCTCTCCCCACA TGTACCAACCTTCCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAATGTTTACTCTGGGCTGGGAGCAGTGGCTCACA CCTGTAATCCCAACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTGAGCAACACTGTGAGACCCC >In-frame_ENST00000233146_ENST00000409585_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=561AA_start in transcript=223_stop in transcript=1908 MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKTGQLQTNRARATVAPLPMTPVPGRASKMPAA -------------------------------------------------------------- >In-frame_ENST00000233146_ENST00000536235_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=2287nt_BP=1609nt GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGA AAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGC TGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTT TGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTC TGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGAT TAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTT ACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCG ACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTT TGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGA CAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGG GCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCC TATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAA GGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATAATGGCTATCTGT GGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTTCAGTGCTGTCCC ACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTGCTACTGTTTACA CAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCTGTGTAAGCAGGT >In-frame_ENST00000233146_ENST00000536235_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=561AA_start in transcript=223_stop in transcript=1908 MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKTGQLQTNRARATVAPLPMTPVPGRASKMPAA -------------------------------------------------------------- >In-frame_ENST00000233146_ENST00000358434_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=1921nt_BP=1609nt GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGA AAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGC TGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTT TGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTC TGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGAT TAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTT ACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCG ACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTT TGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGA CAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGG GCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGT GGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTC >In-frame_ENST00000233146_ENST00000358434_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=566AA_start in transcript=223_stop in transcript=1920 MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASK -------------------------------------------------------------- >In-frame_ENST00000543555_ENST00000290536_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=2472nt_BP=1327nt AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGAAAGAAAAAAAGC TGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGCTGTATTGCCAGA AATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTTTGGACAGTTTGA ACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTCTGTTGAAGATAC CACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGATTAAGCAGCCTCT CATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTTACAAGAAGATTT ACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCGACTCTATCAGGG TATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTTTGTGACTCCTCT TACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGACAGCCTGGAGCT GGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGGGCGGCTCCACCC ACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCC TATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAA GGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATAATGGCTATCTGT GGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTTCAGTGCTGTCCC ACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTGCTACTGTTTACA CAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCTGTGTAAGCAGGT GGATGAGGTCAGATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAAAGCTCATAAAAGACAAGTAAGATTGAAATCC AAGCCTCATTTCAGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAGAGACAAGTGCTTGGTACCTACATGCAAAGTG TGTGTGCTGGGGGGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGACCTACTCCTTTCCTGTTACCCTCTCCCCACA TGTACCAACCTTCCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAATGTTTACTCTGGGCTGGGAGCAGTGGCTCACA CCTGTAATCCCAACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTGAGCAACACTGTGAGACCCC >In-frame_ENST00000543555_ENST00000290536_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=543AA_start in transcript=7_stop in transcript=1638 MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP GGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELT TFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLR RFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQSMLDSLELEP TYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASKMPAASKSSSDAFFLPSEWEKDP -------------------------------------------------------------- >In-frame_ENST00000543555_ENST00000409585_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=2451nt_BP=1327nt AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGAAAGAAAAAAAGC TGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGCTGTATTGCCAGA AATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTTTGGACAGTTTGA ACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTCTGTTGAAGATAC CACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGATTAAGCAGCCTCT CATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTTACAAGAAGATTT ACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCGACTCTATCAGGG TATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTTTGTGACTCCTCT TACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGACAGCCTGGAGCT GGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGGGCGGCTCCACCC ACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCCTATGACTCCTGT CCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAAGGATCCCTCAAG GCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATAATGGCTATCTGTGGTCAGACTTGC TCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTTCAGTGCTGTCCCACTCCTCAAGTC TGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTGCTACTGTTTACACAGGTGAAGATT AAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCTGTGTAAGCAGGTGGATGAGGTCAG ATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAAAGCTCATAAAAGACAAGTAAGATTGAAATCCAAGCCTCATTTC AGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAGAGACAAGTGCTTGGTACCTACATGCAAAGTGTGTGTGCTGGGG GGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGACCTACTCCTTTCCTGTTACCCTCTCCCCACATGTACCAACCTT CCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAATGTTTACTCTGGGCTGGGAGCAGTGGCTCACACCTGTAATCCCA ACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTGAGCAACACTGTGAGACCCCCCCGCCATCTCT >In-frame_ENST00000543555_ENST00000409585_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=539AA_start in transcript=7_stop in transcript=1626 MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP GGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELT TFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLR RFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQSMLDSLELEP -------------------------------------------------------------- >In-frame_ENST00000543555_ENST00000536235_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=2005nt_BP=1327nt AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGAAAGAAAAAAAGC TGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGCTGTATTGCCAGA AATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTTTGGACAGTTTGA ACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTCTGTTGAAGATAC CACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGATTAAGCAGCCTCT CATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTTACAAGAAGATTT ACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCGACTCTATCAGGG TATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTTTGTGACTCCTCT TACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGACAGCCTGGAGCT GGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGGGCGGCTCCACCC ACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCCTATGACTCCTGT CCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAAGGATCCCTCAAG GCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGTTCACATAATGGCTATCTGTGGTCAGACTTGC TCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGTCCTGTTTCAGTGCTGTCCCACTCCTCAAGTC TGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAATCATTTGCTACTGTTTACACAGGTGAAGATT AAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTGTAGCTCTGTGTAAGCAGGTGGATGAGGTCAG >In-frame_ENST00000543555_ENST00000536235_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=539AA_start in transcript=7_stop in transcript=1626 MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP GGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELT TFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLR RFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQSMLDSLELEP -------------------------------------------------------------- >In-frame_ENST00000543555_ENST00000358434_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=1639nt_BP=1327nt AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAGGAGGAATTCTGATCACAGAAAGAAAAAAAGC TGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGCTGTATTGCCAGA AATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCTTATCAGATGATTCCAACTTTGGACAGTTTGA ACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTCTGTTGAAGATAC CACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAGTGGATTAAGCAGCCTCT CATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTTACAAGAAGATTT ACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCGACTCTATCAGGG TATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTTTGTGACTCCTCT TACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATATGGATCAGAGCATGCTGGACAGCCTGGAGCT GGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCATCTATGCCAAGCCTCAGGGGCGGCTCCACCC ACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAGCTACTGTGGCCCCCCTGCC TATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCCTGCCTTCAGAGTGGGAGAA >In-frame_ENST00000543555_ENST00000358434_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=544AA_start in transcript=7_stop in transcript=1638 MGVVAVAGRRSGDVGGEAGNSLVGVGSRIFFNQEVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKAS KENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLP GGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELT TFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLR RFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQSMLDSLELEP TYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASKMPAASKSSSDAFFLPSEWEKDP -------------------------------------------------------------- >In-frame_ENST00000406134_ENST00000290536_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=2593nt_BP=1448nt AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAG GAGGAATTCTGATCACAGAAAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGG GAGAGCAGATGAATAGTGCTGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCT TATCAGATGATTCCAACTTTGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCC TTAACCTTTTTCAGGGTTCTGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAA GACTTGTTAACCAGTGGATTAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATG CAGAATTGAGGCAGACTTTACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAA ACTTACAAGATTGTTACCGACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGA AATTATTGTTGGCAGTTTTTGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATA TGGATCAGAGCATGCTGGACAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCA TCTATGCCAAGCCTCAGGGGCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCA ACCGAGCTCGAGCTACTGTGGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAG ATGCCTTCTTCCTGCCTTCAGAGTGGGAGAAGGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATAT CCATGCTCAGGTTCACATAATGGCTATCTGTGGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAA CAGCCTTCCTGTCCTGTTTCAGTGCTGTCCCACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCA TTTTCTTTAGAATCATTTGCTACTGTTTACACAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAG AATTTCTTCTTGTAGCTCTGTGTAAGCAGGTGGATGAGGTCAGATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAA AGCTCATAAAAGACAAGTAAGATTGAAATCCAAGCCTCATTTCAGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAG AGACAAGTGCTTGGTACCTACATGCAAAGTGTGTGTGCTGGGGGGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGA CCTACTCCTTTCCTGTTACCCTCTCCCCACATGTACCAACCTTCCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAAT GTTTACTCTGGGCTGGGAGCAGTGGCTCACACCTGTAATCCCAACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTC >In-frame_ENST00000406134_ENST00000290536_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=565AA_start in transcript=62_stop in transcript=1759 MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASK -------------------------------------------------------------- >In-frame_ENST00000406134_ENST00000409585_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=2572nt_BP=1448nt AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAG GAGGAATTCTGATCACAGAAAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGG GAGAGCAGATGAATAGTGCTGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCT TATCAGATGATTCCAACTTTGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCC TTAACCTTTTTCAGGGTTCTGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAA GACTTGTTAACCAGTGGATTAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATG CAGAATTGAGGCAGACTTTACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAA ACTTACAAGATTGTTACCGACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGA AATTATTGTTGGCAGTTTTTGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATA TGGATCAGAGCATGCTGGACAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCA TCTATGCCAAGCCTCAGGGGCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAG CTACTGTGGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCC TGCCTTCAGAGTGGGAGAAGGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGT TCACATAATGGCTATCTGTGGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGT CCTGTTTCAGTGCTGTCCCACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAA TCATTTGCTACTGTTTACACAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTG TAGCTCTGTGTAAGCAGGTGGATGAGGTCAGATCACCTTTGGTAAACTGGACCTCAGGAACAAGGATGAGGTTTTGAAAGCTCATAAAAG ACAAGTAAGATTGAAATCCAAGCCTCATTTCAGAGCCTGTGCCCTTCCCACTACACCACCAGGCTTCAGCCTCCAAAGAGACAAGTGCTT GGTACCTACATGCAAAGTGTGTGTGCTGGGGGGTGGGAGGGCTGCCCAGAACAGGGGAGAGGATGGTGTAAAAAAAGACCTACTCCTTTC CTGTTACCCTCTCCCCACATGTACCAACCTTCCTGTTGCTCCCTCCATCCACAGAATAATAGCTACCATTTATAAAATGTTTACTCTGGG CTGGGAGCAGTGGCTCACACCTGTAATCCCAACACTTTGAGAGGCTGAGGTGGGATGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTG >In-frame_ENST00000406134_ENST00000409585_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=561AA_start in transcript=62_stop in transcript=1747 MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKTGQLQTNRARATVAPLPMTPVPGRASKMPAA -------------------------------------------------------------- >In-frame_ENST00000406134_ENST00000536235_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=2126nt_BP=1448nt AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAG GAGGAATTCTGATCACAGAAAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGG GAGAGCAGATGAATAGTGCTGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCT TATCAGATGATTCCAACTTTGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCC TTAACCTTTTTCAGGGTTCTGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAA GACTTGTTAACCAGTGGATTAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATG CAGAATTGAGGCAGACTTTACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAA ACTTACAAGATTGTTACCGACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGA AATTATTGTTGGCAGTTTTTGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATA TGGATCAGAGCATGCTGGACAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCA TCTATGCCAAGCCTCAGGGGCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGACTGGGCAGTTGCAGACCAACCGAGCTCGAG CTACTGTGGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAGATGCCTTCTTCC TGCCTTCAGAGTGGGAGAAGGATCCCTCAAGGCCCTAAGTCACCAGCACCAGAGCCCAGCTGCCCAGCTTAACCATATCCATGCTCAGGT TCACATAATGGCTATCTGTGGTCAGACTTGCTCTCTATCCGCCTGAGCCTCTGTGAGTGAGGGCTGACTGGGAAACAACAGCCTTCCTGT CCTGTTTCAGTGCTGTCCCACTCCTCAAGTCTGGAAGCGACACACCCGAGCCTGTCCTTTCTCCAGCAAGGACTTTCATTTTCTTTAGAA TCATTTGCTACTGTTTACACAGGTGAAGATTAAACACCCAGTAAGCTTCTACCATTGTTAGGAGCATTCATAACTCAGAATTTCTTCTTG >In-frame_ENST00000406134_ENST00000536235_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=561AA_start in transcript=62_stop in transcript=1747 MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKTGQLQTNRARATVAPLPMTPVPGRASKMPAA -------------------------------------------------------------- >In-frame_ENST00000406134_ENST00000358434_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(transcript)=1760nt_BP=1448nt AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATAATTCAAAGAG GAGGAATTCTGATCACAGAAAGAAAAAAAGCTGACTTTTCCACAAAAGACATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGG GAGAGCAGATGAATAGTGCTGTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTTTTAGAACTCT TATCAGATGATTCCAACTTTGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCC TTAACCTTTTTCAGGGTTCTGTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAA GACTTGTTAACCAGTGGATTAAGCAGCCTCTCATGGATAAGAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATG CAGAATTGAGGCAGACTTTACAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAA ACTTACAAGATTGTTACCGACTCTATCAGGGTATAAATCAACTACCTAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGA AATTATTGTTGGCAGTTTTTGTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACAACTTTAGATA TGGATCAGAGCATGCTGGACAGCCTGGAGCTGGAGCCCACCTACAACCCCTTGCATGTTCAAAGCCACCTGTACTCACACCTGAGCAGCA TCTATGCCAAGCCTCAGGGGCGGCTCCACCCACACTGGGAGAGCCGAGCTCCGAGAAAGCATCCCTGCAAGACTGGGCAGTTGCAGACCA ACCGAGCTCGAGCTACTGTGGCCCCCCTGCCTATGACTCCTGTCCCAGGCAGAGCCTCCAAGATGCCAGCAGCCAGCAAATCTTCCTCAG >In-frame_ENST00000406134_ENST00000358434_TCGA-AJ-A23M-01A_MSH2_chr2_47672796_+_M1AP_chr2_74787418_length(amino acids)=566AA_start in transcript=62_stop in transcript=1759 MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSL SAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF QEMIETTLDMDQSMLDSLELEPTYNPLHVQSHLYSHLSSIYAKPQGRLHPHWESRAPRKHPCKTGQLQTNRARATVAPLPMTPVPGRASK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MSH2-M1AP |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | MSH2 | chr2:47672796 | chr2:74787418 | ENST00000233146 | + | 8 | 16 | 601_671 | 462.0 | 935.0 | EXO1 |
Hgene | MSH2 | chr2:47672796 | chr2:74787418 | ENST00000543555 | + | 9 | 17 | 601_671 | 396.0 | 869.0 | EXO1 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MSH2-M1AP |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MSH2-M1AP |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MSH2 | C2936783 | Colorectal cancer, hereditary nonpolyposis, type 1 | 55 | GENOMICS_ENGLAND;UNIPROT |
Hgene | MSH2 | C0265325 | Turcot syndrome (disorder) | 14 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | MSH2 | C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 11 | CLINGEN;CTD_human;ORPHANET |
Hgene | MSH2 | C4321324 | Constitutional Mismatch Repair Deficiency Syndrome | 10 | CLINGEN |
Hgene | MSH2 | C4552100 | Lynch Syndrome | 10 | CLINGEN;CTD_human;GENOMICS_ENGLAND |
Hgene | MSH2 | C0009405 | Hereditary Nonpolyposis Colorectal Neoplasms | 9 | CLINGEN;CTD_human |
Hgene | MSH2 | C1112155 | Hereditary non-polyposis colorectal cancer syndrome | 7 | CLINGEN;ORPHANET |
Hgene | MSH2 | C0009402 | Colorectal Carcinoma | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | MSH2 | C1321489 | Torre-Muir syndrome | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | MSH2 | C0346153 | Breast Cancer, Familial | 2 | CLINGEN |
Hgene | MSH2 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | MSH2 | C0919267 | ovarian neoplasm | 1 | CGI;CTD_human |
Hgene | MSH2 | C1140680 | Malignant neoplasm of ovary | 1 | CGI;CTD_human;GENOMICS_ENGLAND |
Hgene | MSH2 | C2931459 | Lynch syndrome I (site-specific colonic cancer) | 1 | CTD_human |
Hgene | MSH2 | C4733333 | familial non-medullary thyroid cancer | 1 | GENOMICS_ENGLAND |