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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MSL2-OPRM1 (FusionGDB2 ID:55030)

Fusion Gene Summary for MSL2-OPRM1

check button Fusion gene summary
Fusion gene informationFusion gene name: MSL2-OPRM1
Fusion gene ID: 55030
HgeneTgene
Gene symbol

MSL2

OPRM1

Gene ID

55167

4988

Gene nameMSL complex subunit 2opioid receptor mu 1
SynonymsMSL-2|MSL2L1|RNF184LMOR|M-OR-1|MOP|MOR|MOR1|OPRM
Cytomap

3q22.3

6q25.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MSL2E3 ubiquitin-protein transferase MSL2MSL2-like 1male-specific lethal 2 homologmale-specific lethal 2-like 1male-specific lethal-2 homolog 1ring finger protein 184mu-type opioid receptormu opiate receptormu opioid receptor hMOR-1a
Modification date2020031320200322
UniProtAcc

Q9HCI7

.
Ensembl transtripts involved in fusion geneENST00000309993, ENST00000434835, 
ENST00000434900, ENST00000520708, 
ENST00000518759, ENST00000360422, 
ENST00000330432, ENST00000428397, 
ENST00000452687, ENST00000229768, 
ENST00000524163, ENST00000419506, 
ENST00000414028, ENST00000435918, 
ENST00000337049, ENST00000523520, 
ENST00000522555, ENST00000522236, 
Fusion gene scores* DoF score10 X 6 X 9=5407 X 6 X 3=126
# samples 147
** MAII scorelog2(14/540*10)=-1.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MSL2 [Title/Abstract] AND OPRM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMSL2(135913814)-OPRM1(154410961), # samples:2
Anticipated loss of major functional domain due to fusion event.MSL2-OPRM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MSL2-OPRM1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MSL2-OPRM1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSL2

GO:0043984

histone H4-K16 acetylation

20018852


check buttonFusion gene breakpoints across MSL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across OPRM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-63-A5MT-01AMSL2chr3

135913814

-OPRM1chr6

154410961

+
ChimerDB4LUSCTCGA-63-A5MT-01AMSL2chr3

135913814

-OPRM1chr6

154410961

+


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Fusion Gene ORF analysis for MSL2-OPRM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000309993ENST00000434900MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000520708MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000518759MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000360422MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000330432MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000428397MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000452687MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000229768MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000524163MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000419506MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000414028MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000435918MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000337049MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-intronENST00000309993ENST00000523520MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000522555MSL2chr3

135913814

-OPRM1chr6

154410961

+
5CDS-5UTRENST00000309993ENST00000522236MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-3CDSENST00000434835ENST00000434900MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000520708MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000518759MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000360422MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000330432MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000428397MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000452687MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000229768MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000524163MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000419506MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000414028MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000435918MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000337049MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-intronENST00000434835ENST00000523520MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000522555MSL2chr3

135913814

-OPRM1chr6

154410961

+
intron-5UTRENST00000434835ENST00000522236MSL2chr3

135913814

-OPRM1chr6

154410961

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MSL2-OPRM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MSL2-OPRM1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSL2

Q9HCI7

.
FUNCTION: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. {ECO:0000269|PubMed:21726816}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MSL2-OPRM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MSL2-OPRM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MSL2-OPRM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MSL2-OPRM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneOPRM1C0001973Alcoholic Intoxication, Chronic6CTD_human;PSYGENET
TgeneOPRM1C0600427Cocaine Dependence6CTD_human;PSYGENET
TgeneOPRM1C0001969Alcoholic Intoxication5PSYGENET
TgeneOPRM1C0011570Mental Depression4PSYGENET
TgeneOPRM1C0011581Depressive disorder4PSYGENET
TgeneOPRM1C0009171Cocaine Abuse3CTD_human
TgeneOPRM1C0036341Schizophrenia3PSYGENET
TgeneOPRM1C0085762Alcohol abuse3CTD_human;PSYGENET
TgeneOPRM1C0236736Cocaine-Related Disorders3CTD_human
TgeneOPRM1C0019196Hepatitis C2CTD_human
TgeneOPRM1C0022333Jacksonian Seizure2CTD_human
TgeneOPRM1C0027796Neuralgia2CTD_human
TgeneOPRM1C0033975Psychotic Disorders2PSYGENET
TgeneOPRM1C0036572Seizures2CTD_human
TgeneOPRM1C0038870Neuralgia, Supraorbital2CTD_human
TgeneOPRM1C0042656Neuralgia, Vidian2CTD_human
TgeneOPRM1C0149958Complex partial seizures2CTD_human
TgeneOPRM1C0234247Neuralgia, Atypical2CTD_human
TgeneOPRM1C0234249Neuralgia, Stump2CTD_human
TgeneOPRM1C0234533Generalized seizures2CTD_human
TgeneOPRM1C0234535Clonic Seizures2CTD_human
TgeneOPRM1C0270824Visual seizure2CTD_human
TgeneOPRM1C0270844Tonic Seizures2CTD_human
TgeneOPRM1C0270846Epileptic drop attack2CTD_human
TgeneOPRM1C0349204Nonorganic psychosis2PSYGENET
TgeneOPRM1C0422850Seizures, Somatosensory2CTD_human
TgeneOPRM1C0422852Seizures, Auditory2CTD_human
TgeneOPRM1C0422853Olfactory seizure2CTD_human
TgeneOPRM1C0422854Gustatory seizure2CTD_human
TgeneOPRM1C0422855Vertiginous seizure2CTD_human
TgeneOPRM1C0423711Neuralgia, Perineal2CTD_human
TgeneOPRM1C0423712Neuralgia, Iliohypogastric Nerve2CTD_human
TgeneOPRM1C0494475Tonic - clonic seizures2CTD_human
TgeneOPRM1C0751056Non-epileptic convulsion2CTD_human
TgeneOPRM1C0751110Single Seizure2CTD_human
TgeneOPRM1C0751123Atonic Absence Seizures2CTD_human
TgeneOPRM1C0751371Neuralgia, Ilioinguinal2CTD_human
TgeneOPRM1C0751372Nerve Pain2CTD_human
TgeneOPRM1C0751373Paroxysmal Nerve Pain2CTD_human
TgeneOPRM1C0751494Convulsive Seizures2CTD_human
TgeneOPRM1C0751495Seizures, Focal2CTD_human
TgeneOPRM1C0751496Seizures, Sensory2CTD_human
TgeneOPRM1C3495874Nonepileptic Seizures2CTD_human
TgeneOPRM1C4048158Convulsions2CTD_human
TgeneOPRM1C4316903Absence Seizures2CTD_human
TgeneOPRM1C4317109Epileptic Seizures2CTD_human
TgeneOPRM1C4317123Myoclonic Seizures2CTD_human
TgeneOPRM1C4505436Generalized Absence Seizures2CTD_human
TgeneOPRM1C0001849AIDS Dementia Complex1CTD_human
TgeneOPRM1C0001956Alcohol Use Disorder1CTD_human
TgeneOPRM1C0009806Constipation1CTD_human
TgeneOPRM1C0013146Drug abuse1CTD_human
TgeneOPRM1C0013170Drug habituation1CTD_human
TgeneOPRM1C0013222Drug Use Disorders1CTD_human
TgeneOPRM1C0013384Dyskinetic syndrome1CTD_human
TgeneOPRM1C0014544Epilepsy1CTD_human
TgeneOPRM1C0019147Hepatic Coma1CTD_human
TgeneOPRM1C0019151Hepatic Encephalopathy1CTD_human
TgeneOPRM1C0019337Heroin Dependence1CTD_human
TgeneOPRM1C0020429Hyperalgesia1CTD_human
TgeneOPRM1C0020651Hypotension, Orthostatic1CTD_human
TgeneOPRM1C0026552Morphine Dependence1CTD_human
TgeneOPRM1C0026650Movement Disorders1CTD_human
TgeneOPRM1C0027497Nausea1CTD_human
TgeneOPRM1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneOPRM1C0033774Pruritus1CTD_human
TgeneOPRM1C0033937Psychoses, Drug1CTD_human
TgeneOPRM1C0033941Psychoses, Substance-Induced1CTD_human
TgeneOPRM1C0035229Respiratory Insufficiency1CTD_human
TgeneOPRM1C0038580Substance Dependence1CTD_human
TgeneOPRM1C0038586Substance Use Disorders1CTD_human
TgeneOPRM1C0086237Epilepsy, Cryptogenic1CTD_human
TgeneOPRM1C0152115Lingual-Facial-Buccal Dyskinesia1CTD_human
TgeneOPRM1C0206019HIV Encephalopathy1CTD_human
TgeneOPRM1C0221074Depression, Postpartum1PSYGENET
TgeneOPRM1C0221169Hemiballismus1CTD_human
TgeneOPRM1C0232766Asterixis1CTD_human
TgeneOPRM1C0233477Dysphoric mood1PSYGENET
TgeneOPRM1C0235063Respiratory Depression1CTD_human
TgeneOPRM1C0236018Aura1CTD_human
TgeneOPRM1C0236733Amphetamine-Related Disorders1CTD_human
TgeneOPRM1C0236804Amphetamine Addiction1CTD_human
TgeneOPRM1C0236807Amphetamine Abuse1CTD_human
TgeneOPRM1C0236969Substance-Related Disorders1CTD_human
TgeneOPRM1C0237326Dyschezia1CTD_human
TgeneOPRM1C0243010Viral Encephalitis1CTD_human
TgeneOPRM1C0266487Etat Marbre1CTD_human
TgeneOPRM1C0427086Involuntary Movements1CTD_human
TgeneOPRM1C0454606Oral Dyskinesia1CTD_human
TgeneOPRM1C0458247Allodynia1CTD_human
TgeneOPRM1C0600241heroin abuse1CTD_human
TgeneOPRM1C0600272Morphine Abuse1CTD_human
TgeneOPRM1C0740858Substance abuse problem1CTD_human
TgeneOPRM1C0751111Awakening Epilepsy1CTD_human
TgeneOPRM1C0751197Fulminant Hepatic Failure with Cerebral Edema1CTD_human
TgeneOPRM1C0751198Hepatic Stupor1CTD_human
TgeneOPRM1C0751211Hyperalgesia, Primary1CTD_human
TgeneOPRM1C0751212Hyperalgesia, Secondary1CTD_human
TgeneOPRM1C0751213Tactile Allodynia1CTD_human
TgeneOPRM1C0751214Hyperalgesia, Thermal1CTD_human
TgeneOPRM1C0752196Ballismus1CTD_human
TgeneOPRM1C0936243HIV-1-Associated Cognitive Motor Complex1CTD_human
TgeneOPRM1C1145670Respiratory Failure1CTD_human
TgeneOPRM1C1257861Colonic Inertia1CTD_human
TgeneOPRM1C1510472Drug Dependence1CTD_human
TgeneOPRM1C1837893SCHIZOPHRENIA 121PSYGENET
TgeneOPRM1C2936719Mechanical Allodynia1CTD_human
TgeneOPRM1C4316881Prescription Drug Abuse1CTD_human
TgeneOPRM1C4505390Heroin Smoking1CTD_human