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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MSN-HTR3D (FusionGDB2 ID:55068)

Fusion Gene Summary for MSN-HTR3D

check button Fusion gene summary
Fusion gene informationFusion gene name: MSN-HTR3D
Fusion gene ID: 55068
HgeneTgene
Gene symbol

MSN

HTR3D

Gene ID

4478

200909

Gene namemoesin5-hydroxytryptamine receptor 3D
SynonymsHEL70|IMD505HT3D
Cytomap

Xq12

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionmoesinepididymis luminal protein 70membrane-organizing extension spike protein5-hydroxytryptamine receptor 3D5-hydroxytryptamine (serotonin) receptor 3 family member D5-hydroxytryptamine (serotonin) receptor 3D, ionotropic5-hydroxytryptamine receptor 3 subunit Dserotonin 5-HT-3D receptorserotonin receptor 3D
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000609205, ENST00000360270, 
ENST00000334128, ENST00000428798, 
ENST00000382489, ENST00000453435, 
Fusion gene scores* DoF score10 X 11 X 5=5503 X 3 X 2=18
# samples 123
** MAII scorelog2(12/550*10)=-2.1963972128035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MSN [Title/Abstract] AND HTR3D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMSN(64887720)-HTR3D(183755809), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSN

GO:0001771

immunological synapse formation

27405666

HgeneMSN

GO:0042098

T cell proliferation

27405666

HgeneMSN

GO:0070489

T cell aggregation

27405666

HgeneMSN

GO:0071394

cellular response to testosterone stimulus

24065547

HgeneMSN

GO:0072678

T cell migration

27405666


check buttonFusion gene breakpoints across MSN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HTR3D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-5898-01AMSNchrX

64887720

+HTR3Dchr3

183755809

+
ChimerDB4LUSCTCGA-56-5898MSNchrX

64887720

+HTR3Dchr3

183755809

+
ChimerDB4LUSCTCGA-56-5898-01AMSNchrX

64887720

-HTR3Dchr3

183755809

+


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Fusion Gene ORF analysis for MSN-HTR3D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000609205ENST00000334128MSNchrX

64887720

+HTR3Dchr3

183755809

+
intron-3CDSENST00000609205ENST00000428798MSNchrX

64887720

+HTR3Dchr3

183755809

+
intron-3CDSENST00000609205ENST00000382489MSNchrX

64887720

+HTR3Dchr3

183755809

+
intron-3CDSENST00000609205ENST00000453435MSNchrX

64887720

+HTR3Dchr3

183755809

+
In-frameENST00000360270ENST00000334128MSNchrX

64887720

+HTR3Dchr3

183755809

+
In-frameENST00000360270ENST00000428798MSNchrX

64887720

+HTR3Dchr3

183755809

+
In-frameENST00000360270ENST00000382489MSNchrX

64887720

+HTR3Dchr3

183755809

+
In-frameENST00000360270ENST00000453435MSNchrX

64887720

+HTR3Dchr3

183755809

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360270MSNchrX64887720+ENST00000334128HTR3Dchr3183755809+1277184172882236
ENST00000360270MSNchrX64887720+ENST00000428798HTR3Dchr3183755809+883184172882237
ENST00000360270MSNchrX64887720+ENST00000382489HTR3Dchr3183755809+1198184172888238
ENST00000360270MSNchrX64887720+ENST00000453435HTR3Dchr3183755809+1108184172882236

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360270ENST00000334128MSNchrX64887720+HTR3Dchr3183755809+0.132768360.86723167
ENST00000360270ENST00000428798MSNchrX64887720+HTR3Dchr3183755809+0.111074610.8889253
ENST00000360270ENST00000382489MSNchrX64887720+HTR3Dchr3183755809+0.0583992670.94160074
ENST00000360270ENST00000453435MSNchrX64887720+HTR3Dchr3183755809+0.087918770.91208124

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Fusion Genomic Features for MSN-HTR3D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MSN-HTR3D


check button Go to

FGviewer for the breakpoints of chrX:64887720-chr3:183755809

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHTR3DchrX:64887720chr3:183755809ENST0000038248948254_264220.0455.0Topological domainCytoplasmic
TgeneHTR3DchrX:64887720chr3:183755809ENST0000038248948286_306220.0455.0Topological domainExtracellular
TgeneHTR3DchrX:64887720chr3:183755809ENST0000038248948328_431220.0455.0Topological domainCytoplasmic
TgeneHTR3DchrX:64887720chr3:183755809ENST0000038248948453_454220.0455.0Topological domainExtracellular
TgeneHTR3DchrX:64887720chr3:183755809ENST0000042879848254_264172.0405.0Topological domainCytoplasmic
TgeneHTR3DchrX:64887720chr3:183755809ENST0000042879848286_306172.0405.0Topological domainExtracellular
TgeneHTR3DchrX:64887720chr3:183755809ENST0000042879848328_431172.0405.0Topological domainCytoplasmic
TgeneHTR3DchrX:64887720chr3:183755809ENST0000042879848453_454172.0405.0Topological domainExtracellular
TgeneHTR3DchrX:64887720chr3:183755809ENST0000045343504254_2641.0234.0Topological domainCytoplasmic
TgeneHTR3DchrX:64887720chr3:183755809ENST000004534350425_2321.0234.0Topological domainExtracellular
TgeneHTR3DchrX:64887720chr3:183755809ENST0000045343504286_3061.0234.0Topological domainExtracellular
TgeneHTR3DchrX:64887720chr3:183755809ENST0000045343504328_4311.0234.0Topological domainCytoplasmic
TgeneHTR3DchrX:64887720chr3:183755809ENST0000045343504453_4541.0234.0Topological domainExtracellular
TgeneHTR3DchrX:64887720chr3:183755809ENST0000038248948233_253220.0455.0TransmembraneHelical%3B Name%3D1
TgeneHTR3DchrX:64887720chr3:183755809ENST0000038248948265_285220.0455.0TransmembraneHelical%3B Name%3D2
TgeneHTR3DchrX:64887720chr3:183755809ENST0000038248948307_327220.0455.0TransmembraneHelical%3B Name%3D3
TgeneHTR3DchrX:64887720chr3:183755809ENST0000038248948432_452220.0455.0TransmembraneHelical%3B Name%3D4
TgeneHTR3DchrX:64887720chr3:183755809ENST0000042879848233_253172.0405.0TransmembraneHelical%3B Name%3D1
TgeneHTR3DchrX:64887720chr3:183755809ENST0000042879848265_285172.0405.0TransmembraneHelical%3B Name%3D2
TgeneHTR3DchrX:64887720chr3:183755809ENST0000042879848307_327172.0405.0TransmembraneHelical%3B Name%3D3
TgeneHTR3DchrX:64887720chr3:183755809ENST0000042879848432_452172.0405.0TransmembraneHelical%3B Name%3D4
TgeneHTR3DchrX:64887720chr3:183755809ENST0000045343504233_2531.0234.0TransmembraneHelical%3B Name%3D1
TgeneHTR3DchrX:64887720chr3:183755809ENST0000045343504265_2851.0234.0TransmembraneHelical%3B Name%3D2
TgeneHTR3DchrX:64887720chr3:183755809ENST0000045343504307_3271.0234.0TransmembraneHelical%3B Name%3D3
TgeneHTR3DchrX:64887720chr3:183755809ENST0000045343504432_4521.0234.0TransmembraneHelical%3B Name%3D4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMSNchrX:64887720chr3:183755809ENST00000360270+1132_2954.0578.0DomainFERM
HgeneMSNchrX:64887720chr3:183755809ENST00000360270+113115_1204.0578.0Motif[IL]-x-C-x-x-[DE] motif
TgeneHTR3DchrX:64887720chr3:183755809ENST000003824894825_232220.0455.0Topological domainExtracellular
TgeneHTR3DchrX:64887720chr3:183755809ENST000004287984825_232172.0405.0Topological domainExtracellular


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Fusion Gene Sequence for MSN-HTR3D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000360270_ENST00000334128_TCGA-56-5898-01A_MSN_chrX_64887720_+_HTR3D_chr3_183755809_length(transcript)=1277nt_BP=184nt
GGGTTTGTGAAGTCGTGGCCCGTTAGCAGGAAGCCTAACAGTCGCCCCGACGCTAGTGAGGGACCCAATCTGAGTCCCCGGCCAGCCGAA
TCCAAGCCGTGTGTACTGCGTGCTCAGCACTGCCCGACAGTCCTAGCTAAACTTCGCCAACTCCGCTGCCTTTGCCGCCACCATGCCCAA
AACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATCGATGCCCT
CAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTCATGATGAA
TGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTACGTCCTCATCCATCAAGAGACCAAAAGCGAGGTGTCTACTTCGC
CCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCTACCTCT
GCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCCGGG
TCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTGACAGGGGG
CTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGATGGACGC
CCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGCCTCTGGAACACCTAGGCAGGTGCTCACCTGCA
AACTTCAGTCTGGACTTCTTTTTGCCAGAGAACTCCAGAAACCAGTCAGGCTCTCAGTCAGCCTTGTGGCCCTGTCAACCGCCTCATTTT
TAACCCAGTCCTCTGTGTAGTTTCAGACCAGACCTGAATAGTCTCCTATGCCCTCCAAAAGTCGGGTCCTTGCTCCTGCATGCCATCAGC
CCCACTCAGCCCTCCCATACCTCCCTGGCTCCTCAGGATTCAGGTTCCTAGGGTACGTCCTTGATTAAATCACCCCAATATGCCCCTTTG
CAGAAAGTATTGGCTTTTCCCTGAATTCTGTTATGGTAAAAAAAATCTTGGGATTGAGAGTCTTCTTGCAGAAACTTCTCAGCCAAAGTA

>In-frame_ENST00000360270_ENST00000334128_TCGA-56-5898-01A_MSN_chrX_64887720_+_HTR3D_chr3_183755809_length(amino acids)=236AA_start in transcript=172_stop in transcript=882
MPKTVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGV
YFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAEL

--------------------------------------------------------------
>In-frame_ENST00000360270_ENST00000428798_TCGA-56-5898-01A_MSN_chrX_64887720_+_HTR3D_chr3_183755809_length(transcript)=883nt_BP=184nt
GGGTTTGTGAAGTCGTGGCCCGTTAGCAGGAAGCCTAACAGTCGCCCCGACGCTAGTGAGGGACCCAATCTGAGTCCCCGGCCAGCCGAA
TCCAAGCCGTGTGTACTGCGTGCTCAGCACTGCCCGACAGTCCTAGCTAAACTTCGCCAACTCCGCTGCCTTTGCCGCCACCATGCCCAA
AACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATCGATGCCCT
CAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTCATGATGAA
TGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTACGTCCTCATCCATCAAGAGACCAAAAGCGAGGTGTCTACTTCGC
CCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCTACCTCT
GCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCCGGG
TCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTGACAGGGGG
CTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGATGGACGC

>In-frame_ENST00000360270_ENST00000428798_TCGA-56-5898-01A_MSN_chrX_64887720_+_HTR3D_chr3_183755809_length(amino acids)=237AA_start in transcript=172_stop in transcript=882
MPKTVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGV
YFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAEL

--------------------------------------------------------------
>In-frame_ENST00000360270_ENST00000382489_TCGA-56-5898-01A_MSN_chrX_64887720_+_HTR3D_chr3_183755809_length(transcript)=1198nt_BP=184nt
GGGTTTGTGAAGTCGTGGCCCGTTAGCAGGAAGCCTAACAGTCGCCCCGACGCTAGTGAGGGACCCAATCTGAGTCCCCGGCCAGCCGAA
TCCAAGCCGTGTGTACTGCGTGCTCAGCACTGCCCGACAGTCCTAGCTAAACTTCGCCAACTCCGCTGCCTTTGCCGCCACCATGCCCAA
AACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATCGATGCCCT
CAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTCATGATGAA
TGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTGGCGCCTCTGGCCCTCATGCAGACCCCCTTGCCTGCAGGTGTCTA
CTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCT
ACCTCTGCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGG
CCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTGAC
AGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGAT
GGACGCCCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGCCTCTGGAACACCTAGGCAGGTGCTCA
CCTGCAAACTTCAGTCTGGACTTCTTTTTGCCAGAGAACTCCAGAAACCAGTCAGGCTCTCAGTCAGCCTTGTGGCCCTGTCAACCGCCT
CATTTTTAACCCAGTCCTCTGTGTAGTTTCAGACCAGACCTGAATAGTCTCCTATGCCCTCCAAAAGTCGGGTCCTTGCTCCTGCATGCC
ATCAGCCCCACTCAGCCCTCCCATACCTCCCTGGCTCCTCAGGATTCAGGTTCCTAGGGTACGTCCTTGATTAAATCACCCCAATATGCC

>In-frame_ENST00000360270_ENST00000382489_TCGA-56-5898-01A_MSN_chrX_64887720_+_HTR3D_chr3_183755809_length(amino acids)=238AA_start in transcript=172_stop in transcript=888
MPKTVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALMQTPLPA
GVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEA

--------------------------------------------------------------
>In-frame_ENST00000360270_ENST00000453435_TCGA-56-5898-01A_MSN_chrX_64887720_+_HTR3D_chr3_183755809_length(transcript)=1108nt_BP=184nt
GGGTTTGTGAAGTCGTGGCCCGTTAGCAGGAAGCCTAACAGTCGCCCCGACGCTAGTGAGGGACCCAATCTGAGTCCCCGGCCAGCCGAA
TCCAAGCCGTGTGTACTGCGTGCTCAGCACTGCCCGACAGTCCTAGCTAAACTTCGCCAACTCCGCTGCCTTTGCCGCCACCATGCCCAA
AACGGTGGCCATCAGGCGCAGGTGCAGGCCCAGCCCCTACGTGGTAAACTTTCTGGTGCCCAGTGGCATTCTGATTGCCATCGATGCCCT
CAGTTTCTACCTGCCACTGGAAAGTGGGAATTGTGCCCCATTCAAGATGACTGTTCTGCTGGGCTACAGCGTCTTCCTGCTCATGATGAA
TGACTTGCTCCCAGCCACTAGCACTTCATCACATGCTTCACTAGTACGTCCTCATCCATCAAGAGACCAAAAGCGAGGTGTCTACTTCGC
CCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCTACCTCT
GCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCCGGG
TCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTGACAGGGGG
CTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGATGGACGC
CCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGCCTCTGGAACACCTAGGCAGGTGCTCACCTGCA
AACTTCAGTCTGGACTTCTTTTTGCCAGAGAACTCCAGAAACCAGTCAGGCTCTCAGTCAGCCTTGTGGCCCTGTCAACCGCCTCATTTT
TAACCCAGTCCTCTGTGTAGTTTCAGACCAGACCTGAATAGTCTCCTATGCCCTCCAAAAGTCGGGTCCTTGCTCCTGCATGCCATCAGC

>In-frame_ENST00000360270_ENST00000453435_TCGA-56-5898-01A_MSN_chrX_64887720_+_HTR3D_chr3_183755809_length(amino acids)=236AA_start in transcript=172_stop in transcript=882
MPKTVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGV
YFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAEL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MSN-HTR3D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MSN-HTR3D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MSN-HTR3D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMSNC4310812IMMUNODEFICIENCY 502CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneMSNC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneMSNC0029408Degenerative polyarthritis1CTD_human
HgeneMSNC0086743Osteoarthrosis Deformans1CTD_human
HgeneMSNC0087031Juvenile-Onset Still Disease1CTD_human
HgeneMSNC0151744Myocardial Ischemia1CTD_human
HgeneMSNC0494261Combined immunodeficiency1GENOMICS_ENGLAND
HgeneMSNC3495559Juvenile arthritis1CTD_human
HgeneMSNC3714758Juvenile psoriatic arthritis1CTD_human
HgeneMSNC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneMSNC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneHTR3DC0036341Schizophrenia1PSYGENET