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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MSRA-LPL (FusionGDB2 ID:55084)

Fusion Gene Summary for MSRA-LPL

check button Fusion gene summary
Fusion gene informationFusion gene name: MSRA-LPL
Fusion gene ID: 55084
HgeneTgene
Gene symbol

MSRA

LPL

Gene ID

4482

4023

Gene namemethionine sulfoxide reductase Alipoprotein lipase
SynonymsPMSRHDLCQ11|LIPD
Cytomap

8p23.1

8p21.3

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial peptide methionine sulfoxide reductasecytosolic methionine-S-sulfoxide reductasepeptide Met(O) reductasepeptide met (O) reductasepeptide-methionine (S)-S-oxide reductaselipoprotein lipase
Modification date2020031320200329
UniProtAcc.

P06858

Ensembl transtripts involved in fusion geneENST00000317173, ENST00000441698, 
ENST00000518255, ENST00000521209, 
ENST00000528246, ENST00000382490, 
ENST00000517594, 		ENST00000311322, 
ENST00000521994, 
Fusion gene scores* DoF score12 X 9 X 6=6483 X 3 X 3=27
# samples 134
** MAII scorelog2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MSRA [Title/Abstract] AND LPL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMSRA(10102733)-LPL(19805690), # samples:1
MSRA(10102733)-LPL(19805691), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLPL

GO:0006631

fatty acid metabolic process

11342582|27578112

TgeneLPL

GO:0006633

fatty acid biosynthetic process

182536

TgeneLPL

GO:0019433

triglyceride catabolic process

182536|2110364|2340307|3973011|11342582|27578112|30559189

TgeneLPL

GO:0034372

very-low-density lipoprotein particle remodeling

3973011


check buttonFusion gene breakpoints across MSRA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LPL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A91NMSRAchr8

10102733

+LPLchr8

19805690

+
ChimerDB4STADTCGA-VQ-A91N-01AMSRAchr8

10102733

+LPLchr8

19805691

+


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Fusion Gene ORF analysis for MSRA-LPL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000317173ENST00000311322MSRAchr8

10102733

+LPLchr8

19805690

+
5CDS-3UTRENST00000317173ENST00000521994MSRAchr8

10102733

+LPLchr8

19805690

+
intron-3CDSENST00000441698ENST00000311322MSRAchr8

10102733

+LPLchr8

19805690

+
intron-3UTRENST00000441698ENST00000521994MSRAchr8

10102733

+LPLchr8

19805690

+
In-frameENST00000518255ENST00000311322MSRAchr8

10102733

+LPLchr8

19805690

+
5CDS-3UTRENST00000518255ENST00000521994MSRAchr8

10102733

+LPLchr8

19805690

+
In-frameENST00000521209ENST00000311322MSRAchr8

10102733

+LPLchr8

19805690

+
5CDS-3UTRENST00000521209ENST00000521994MSRAchr8

10102733

+LPLchr8

19805690

+
In-frameENST00000528246ENST00000311322MSRAchr8

10102733

+LPLchr8

19805690

+
5CDS-3UTRENST00000528246ENST00000521994MSRAchr8

10102733

+LPLchr8

19805690

+
In-frameENST00000382490ENST00000311322MSRAchr8

10102733

+LPLchr8

19805690

+
5CDS-3UTRENST00000382490ENST00000521994MSRAchr8

10102733

+LPLchr8

19805690

+
intron-3CDSENST00000517594ENST00000311322MSRAchr8

10102733

+LPLchr8

19805690

+
intron-3UTRENST00000517594ENST00000521994MSRAchr8

10102733

+LPLchr8

19805690

+
In-frameENST00000317173ENST00000311322MSRAchr8

10102733

+LPLchr8

19805691

+
5CDS-3UTRENST00000317173ENST00000521994MSRAchr8

10102733

+LPLchr8

19805691

+
intron-3CDSENST00000441698ENST00000311322MSRAchr8

10102733

+LPLchr8

19805691

+
intron-3UTRENST00000441698ENST00000521994MSRAchr8

10102733

+LPLchr8

19805691

+
In-frameENST00000518255ENST00000311322MSRAchr8

10102733

+LPLchr8

19805691

+
5CDS-3UTRENST00000518255ENST00000521994MSRAchr8

10102733

+LPLchr8

19805691

+
In-frameENST00000521209ENST00000311322MSRAchr8

10102733

+LPLchr8

19805691

+
5CDS-3UTRENST00000521209ENST00000521994MSRAchr8

10102733

+LPLchr8

19805691

+
In-frameENST00000528246ENST00000311322MSRAchr8

10102733

+LPLchr8

19805691

+
5CDS-3UTRENST00000528246ENST00000521994MSRAchr8

10102733

+LPLchr8

19805691

+
In-frameENST00000382490ENST00000311322MSRAchr8

10102733

+LPLchr8

19805691

+
5CDS-3UTRENST00000382490ENST00000521994MSRAchr8

10102733

+LPLchr8

19805691

+
intron-3CDSENST00000517594ENST00000311322MSRAchr8

10102733

+LPLchr8

19805691

+
intron-3UTRENST00000517594ENST00000521994MSRAchr8

10102733

+LPLchr8

19805691

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317173MSRAchr810102733+ENST00000311322LPLchr819805690+38685802491919556
ENST00000518255MSRAchr810102733+ENST00000311322LPLchr819805690+3635347161686556
ENST00000521209MSRAchr810102733+ENST00000311322LPLchr819805690+36073191861658490
ENST00000528246MSRAchr810102733+ENST00000311322LPLchr819805690+40447566232095490
ENST00000382490MSRAchr810102733+ENST00000311322LPLchr819805690+37945062501845531
ENST00000317173MSRAchr810102733+ENST00000311322LPLchr819805691+38685802491919556
ENST00000518255MSRAchr810102733+ENST00000311322LPLchr819805691+3635347161686556
ENST00000521209MSRAchr810102733+ENST00000311322LPLchr819805691+36073191861658490
ENST00000528246MSRAchr810102733+ENST00000311322LPLchr819805691+40447566232095490
ENST00000382490MSRAchr810102733+ENST00000311322LPLchr819805691+37945062501845531

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317173ENST00000311322MSRAchr810102733+LPLchr819805690+0.0002790510.9997209
ENST00000518255ENST00000311322MSRAchr810102733+LPLchr819805690+0.00024650.99975353
ENST00000521209ENST00000311322MSRAchr810102733+LPLchr819805690+0.0004628310.9995372
ENST00000528246ENST00000311322MSRAchr810102733+LPLchr819805690+0.000511660.99948835
ENST00000382490ENST00000311322MSRAchr810102733+LPLchr819805690+0.0003310440.99966896
ENST00000317173ENST00000311322MSRAchr810102733+LPLchr819805691+0.0002790510.9997209
ENST00000518255ENST00000311322MSRAchr810102733+LPLchr819805691+0.00024650.99975353
ENST00000521209ENST00000311322MSRAchr810102733+LPLchr819805691+0.0004628310.9995372
ENST00000528246ENST00000311322MSRAchr810102733+LPLchr819805691+0.000511660.99948835
ENST00000382490ENST00000311322MSRAchr810102733+LPLchr819805691+0.0003310440.99966896

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Fusion Genomic Features for MSRA-LPL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MSRA-LPL


check button Go to

FGviewer for the breakpoints of chr8:10102733-chr8:19805690

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LPL

P06858

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:8675619, PubMed:11342582, PubMed:27578112). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (PubMed:7592706, PubMed:12032167). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (PubMed:24726386). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (PubMed:11342582, PubMed:27811232). {ECO:0000269|PubMed:11342582, ECO:0000269|PubMed:12032167, ECO:0000269|PubMed:24726386, ECO:0000269|PubMed:27578112, ECO:0000269|PubMed:27811232, ECO:0000269|PubMed:7592706, ECO:0000269|PubMed:8675619}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLPLchr8:10102733chr8:19805690ENST00000311322010341_46429.333333333333332476.0DomainPLAT
TgeneLPLchr8:10102733chr8:19805691ENST00000311322010341_46429.333333333333332476.0DomainPLAT
TgeneLPLchr8:10102733chr8:19805690ENST00000311322010430_43429.333333333333332476.0RegionImportant for heparin binding
TgeneLPLchr8:10102733chr8:19805691ENST00000311322010430_43429.333333333333332476.0RegionImportant for heparin binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MSRA-LPL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000317173_ENST00000311322_TCGA-VQ-A91N_MSRA_chr8_10102733_+_LPL_chr8_19805690_length(transcript)=3868nt_BP=580nt
GGAACTCGCCGGGCCACACCCCCTGTCCAGGGAAGGAACACGCCCCCGGTGACAGCCGGTACGGCCCCGGGTTTGGGCAACCTCGATTAC
GGGCGGCCTCCAGCCCCGCCAGCAGCGCCCCGCGCCCGCCCGCCCGCGCCCCTGCCGCCCCCCGGTTCCGGCCGCGGACCCCACTCTCTG
CCGTTCCGGCTGCGGCTCCGCTGCCGGTAGCGCCGTCCCCCGGGACCACCCTTCGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGG
GCTTGCCAGCTCCTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAACTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTG
CCGGGCCGGAAGGAACAGACCCCTGTAGCGGCCAAACATCATGTCAATGGCAACAGAACAGTCGAACCTTTCCCAGAGGGAACACAGATG
GCTGTATTTGGAATGGGATGTTTCTGGGGAGCTGAAAGGAAATTCTGGGTCTTGAAAGGAGTGTATTCAACTCAAGTTGGTTTTGCAGGA
GGCTATACTTCAAATCCTACTTATAAAGAAGTCTGCTCAGAAAGAAGAGATTTTATCGACATCGAAAGTAAATTTGCCCTAAGGACCCCT
GAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGTGGCTACCTGTCATTTCAATCACAGCAGCAAAACCTTC
ATGGTGATCCATGGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTACAAGAGAGAACCAGACTCC
AATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTCCGCGGGCTACACCAAACTGGTGGGACAGGATGTGGCC
CGGTTTATCAACTGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTTGGAGCCCATGCTGCTGGC
ATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCCAGCTGGACCTAACTTTGAGTATGCAGAAGCCCCGAGT
CGTCTTTCTCCTGATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGCATTGGAATCCAGAAACCA
GTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAGCCAGGATGTAACATTGGAGAAGCTATCCGCGTGATTGCAGAGAGAGGA
CTTGGAGATGTGGACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTGAATGAAGAAAATCCAAGT
AAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGGCTCTGCTTGAGTTGTAGAAAGAACCGCTGCAACAATCTGGGCTATGAG
ATCAATAAAGTCAGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTCTTCCATTACCAAGTAAAG
ATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAGGCCTTTGAGATTTCTCTGTATGGCACCGTGGCCGAGAGTGAGAACATC
CCATTCACTCTGCCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTACACAGAGGTAGATATTGGAGAACTACTCATGTTGAAG
CTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGGTGGAGCAGTCCCGGCTTCGCCATTCAGAAGATCAGAGTAAAAGCAGGA
GAGACTCAGAAAAAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCGGTATTTGTGAAATGCCAT
GACAAGTCTCTGAATAAGAAGTCAGGCTGAAACTGGGCGAATCTACAGAACAAAGAACGGCATGTGAATTCTGTGAAGAATGAAGTGGAG
GAAGTAACTTTTACAAAACATACCCAGTGTTTGGGGTGTTTCAAAAGTGGATTTTCCTGAATATTAATCCCAGCCCTACCCTTGTTAGTT
ATTTTAGGAGACAGTCTCAAGCACTAAAAAGTGGCTAATTCAATTTATGGGGTATAGTGGCCAAATAGCACATCCTCCAACGTTAAAAGA
CAGTGGATCATGAAAAGTGCTGTTTTGTCCTTTGAGAAAGAAATAATTGTTTGAGCGCAGAGTAAAATAAGGCTCCTTCATGTGGCGTAT
TGGGCCATAGCCTATAATTGGTTAGAACCTCCTATTTTAATTGGAATTCTGGATCTTTCGGACTGAGGCCTTCTCAAACTTTACTCTAAG
TCTCCAAGAATACAGAAAATGCTTTTCCGCGGCACGAATCAGACTCATCTACACAGCAGTATGAATGATGTTTTAGAATGATTCCCTCTT
GCTATTGGAATGTGGTCCAGACGTCAACCAGGAACATGTAACTTGGAGAGGGACGAAGAAAGGGTCTGATAAACACAGAGGTTTTAAACA
GTCCCTACCATTGGCCTGCATCATGACAAAGTTACAAATTCAAGGAGATATAAAATCTAGATCAATTAATTCTTAATAGGCTTTATCGTT
TATTGCTTAATCCCTCTCTCCCCCTTCTTTTTTGTCTCAAGATTATATTATAATAATGTTCTCTGGGTAGGTGTTGAAAATGAGCCTGTA
ATCCTCAGCTGACACATAATTTGAATGGTGCAGAAAAAAAAAAAGAAACCGTAATTTTATTATTAGATTCTCCAAATGATTTTCATCAAT
TTAAAATCATTCAATATCTGACAGTTACTCTTCAGTTTTAGGCTTACCTTGGTCATGCTTCAGTTGTACTTCCAGTGCGTCTCTTTTGTT
CCTGGCTTTGACATGAAAAGATAGGTTTGAGTTCAAATTTTGCATTGTGTGAGCTTCTACAGATTTTAGACAAGGACCGTTTTTACTAAG
TAAAAGGGTGGAGAGGTTCCTGGGGTGGATTCCTAAGCAGTGCTTGTAAACCATCGCGTGCAATGAGCCAGATGGAGTACCATGAGGGTT
GCTATTTGTTGTTTTTAACAACTAATCAAGAGTGAGTGAACAACTATTTATAAACTAGATCTCCTATTTTTCAGAATGCTCTTCTACGTA
TAAATATGAAATGATAAAGATGTCAAATATCTCAGAGGCTATAGCTGGGAACCCGACTGTGAAAGTATGTGATATCTGAACACATACTAG
AAAGCTCTGCATGTGTGTTGTCCTTCAGCATAATTCGGAAGGGAAAACAGTCGATCAAGGGATGTATTGGAACATGTCGGAGTAGAAATT
GTTCCTGATGTGCCAGAACTTCGACCCTTTCTCTGAGAGAGATGATCGTGCCTATAAATAGTAGGACCAATGTTGTGATTAACATCATCA
GGCTTGGAATGAATTCTCTCTAAAAATAAAATGATGTATGATTTGTTGTTGGCATCCCCTTTATTAATTCATTAAATTTCTGGATTTGGG
TTGTGACCCAGGGTGCATTAACTTAAAAGATTCACTAAAGCAGCACATAGCACTGGGAACTCTGGCTCCGAAAAACTTTGTTATATATAT
CAAGGATGTTCTGGCTTTACATTTTATTTATTAGCTGTAAATACATGTGTGGATGTGTAAATGGAGCTTGTACATATTGGAAAGGTCATT
GTGGCTATCTGCATTTATAAATGTGTGGTGCTAACTGTATGTGTCTTTATCAGTGATGGTCTCACAGAGCCAACTCACTCTTATGAAATG

>In-frame_ENST00000317173_ENST00000311322_TCGA-VQ-A91N_MSRA_chr8_10102733_+_LPL_chr8_19805690_length(amino acids)=556AA_start in transcript=249_stop in transcript=1919
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYS
TQVGFAGGYTSNPTYKEVCSERRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAAL
YKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNF
EYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSL
LNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGT
VAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAP

--------------------------------------------------------------
>In-frame_ENST00000518255_ENST00000311322_TCGA-VQ-A91N_MSRA_chr8_10102733_+_LPL_chr8_19805690_length(transcript)=3635nt_BP=347nt
CGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGGGCTTGCCAGCTCCTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAA
CTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTGCCGGGCCGGAAGGAACAGACCCCTGTAGCGGCCAAACATCATGTCAATGGCAA
CAGAACAGTCGAACCTTTCCCAGAGGGAACACAGATGGCTGTATTTGGAATGGGATGTTTCTGGGGAGCTGAAAGGAAATTCTGGGTCTT
GAAAGGAGTGTATTCAACTCAAGTTGGTTTTGCAGGAGGCTATACTTCAAATCCTACTTATAAAGAAGTCTGCTCAGAAAGAAGAGATTT
TATCGACATCGAAAGTAAATTTGCCCTAAGGACCCCTGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGT
GGCTACCTGTCATTTCAATCACAGCAGCAAAACCTTCATGGTGATCCATGGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAA
ACTTGTGGCCGCCCTGTACAAGAGAGAACCAGACTCCAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTC
CGCGGGCTACACCAAACTGGTGGGACAGGATGTGGCCCGGTTTATCAACTGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCA
TCTCTTGGGATACAGCCTTGGAGCCCATGCTGCTGGCATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCC
AGCTGGACCTAACTTTGAGTATGCAGAAGCCCCGAGTCGTCTTTCTCCTGATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAG
AGGGTCCCCTGGTCGAAGCATTGGAATCCAGAAACCAGTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAGCCAGGATGTAA
CATTGGAGAAGCTATCCGCGTGATTGCAGAGAGAGGACTTGGAGATGTGGACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCT
CTTCATCGACTCTCTGTTGAATGAAGAAAATCCAAGTAAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGGCTCTGCTTGAG
TTGTAGAAAGAACCGCTGCAACAATCTGGGCTATGAGATCAATAAAGTCAGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTC
TCAGATGCCCTACAAAGTCTTCCATTACCAAGTAAAGATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAGGCCTTTGAGAT
TTCTCTGTATGGCACCGTGGCCGAGAGTGAGAACATCCCATTCACTCTGCCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTA
CACAGAGGTAGATATTGGAGAACTACTCATGTTGAAGCTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGGTGGAGCAGTCC
CGGCTTCGCCATTCAGAAGATCAGAGTAAAAGCAGGAGAGACTCAGAAAAAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCA
GAAAGGAAAGGCACCTGCGGTATTTGTGAAATGCCATGACAAGTCTCTGAATAAGAAGTCAGGCTGAAACTGGGCGAATCTACAGAACAA
AGAACGGCATGTGAATTCTGTGAAGAATGAAGTGGAGGAAGTAACTTTTACAAAACATACCCAGTGTTTGGGGTGTTTCAAAAGTGGATT
TTCCTGAATATTAATCCCAGCCCTACCCTTGTTAGTTATTTTAGGAGACAGTCTCAAGCACTAAAAAGTGGCTAATTCAATTTATGGGGT
ATAGTGGCCAAATAGCACATCCTCCAACGTTAAAAGACAGTGGATCATGAAAAGTGCTGTTTTGTCCTTTGAGAAAGAAATAATTGTTTG
AGCGCAGAGTAAAATAAGGCTCCTTCATGTGGCGTATTGGGCCATAGCCTATAATTGGTTAGAACCTCCTATTTTAATTGGAATTCTGGA
TCTTTCGGACTGAGGCCTTCTCAAACTTTACTCTAAGTCTCCAAGAATACAGAAAATGCTTTTCCGCGGCACGAATCAGACTCATCTACA
CAGCAGTATGAATGATGTTTTAGAATGATTCCCTCTTGCTATTGGAATGTGGTCCAGACGTCAACCAGGAACATGTAACTTGGAGAGGGA
CGAAGAAAGGGTCTGATAAACACAGAGGTTTTAAACAGTCCCTACCATTGGCCTGCATCATGACAAAGTTACAAATTCAAGGAGATATAA
AATCTAGATCAATTAATTCTTAATAGGCTTTATCGTTTATTGCTTAATCCCTCTCTCCCCCTTCTTTTTTGTCTCAAGATTATATTATAA
TAATGTTCTCTGGGTAGGTGTTGAAAATGAGCCTGTAATCCTCAGCTGACACATAATTTGAATGGTGCAGAAAAAAAAAAAGAAACCGTA
ATTTTATTATTAGATTCTCCAAATGATTTTCATCAATTTAAAATCATTCAATATCTGACAGTTACTCTTCAGTTTTAGGCTTACCTTGGT
CATGCTTCAGTTGTACTTCCAGTGCGTCTCTTTTGTTCCTGGCTTTGACATGAAAAGATAGGTTTGAGTTCAAATTTTGCATTGTGTGAG
CTTCTACAGATTTTAGACAAGGACCGTTTTTACTAAGTAAAAGGGTGGAGAGGTTCCTGGGGTGGATTCCTAAGCAGTGCTTGTAAACCA
TCGCGTGCAATGAGCCAGATGGAGTACCATGAGGGTTGCTATTTGTTGTTTTTAACAACTAATCAAGAGTGAGTGAACAACTATTTATAA
ACTAGATCTCCTATTTTTCAGAATGCTCTTCTACGTATAAATATGAAATGATAAAGATGTCAAATATCTCAGAGGCTATAGCTGGGAACC
CGACTGTGAAAGTATGTGATATCTGAACACATACTAGAAAGCTCTGCATGTGTGTTGTCCTTCAGCATAATTCGGAAGGGAAAACAGTCG
ATCAAGGGATGTATTGGAACATGTCGGAGTAGAAATTGTTCCTGATGTGCCAGAACTTCGACCCTTTCTCTGAGAGAGATGATCGTGCCT
ATAAATAGTAGGACCAATGTTGTGATTAACATCATCAGGCTTGGAATGAATTCTCTCTAAAAATAAAATGATGTATGATTTGTTGTTGGC
ATCCCCTTTATTAATTCATTAAATTTCTGGATTTGGGTTGTGACCCAGGGTGCATTAACTTAAAAGATTCACTAAAGCAGCACATAGCAC
TGGGAACTCTGGCTCCGAAAAACTTTGTTATATATATCAAGGATGTTCTGGCTTTACATTTTATTTATTAGCTGTAAATACATGTGTGGA
TGTGTAAATGGAGCTTGTACATATTGGAAAGGTCATTGTGGCTATCTGCATTTATAAATGTGTGGTGCTAACTGTATGTGTCTTTATCAG
TGATGGTCTCACAGAGCCAACTCACTCTTATGAAATGGGCTTTAACAAAACAAGAAAGAAACGTACTTAACTGTGTGAAGAAATGGAATC

>In-frame_ENST00000518255_ENST00000311322_TCGA-VQ-A91N_MSRA_chr8_10102733_+_LPL_chr8_19805690_length(amino acids)=556AA_start in transcript=16_stop in transcript=1686
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYS
TQVGFAGGYTSNPTYKEVCSERRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAAL
YKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNF
EYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSL
LNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGT
VAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAP

--------------------------------------------------------------
>In-frame_ENST00000521209_ENST00000311322_TCGA-VQ-A91N_MSRA_chr8_10102733_+_LPL_chr8_19805690_length(transcript)=3607nt_BP=319nt
TGAATGATAGATTATTATTTTACATTGTAGGTACAGCCAGTGTGATCAGACAAAGCAATTCGAGAACTACAAAAGAGGAAAAAAGATCAG
AAGTTCTTAAATACATAAGGGAATGCAGCATTTGATAAAGCCAAACATCATGTCAATGGCAACAGAACAGTCGAACCTTTCCCAGAGGGA
ACACAGATGGCTGTATTTGGAATGGGATGTTTCTGGGGAGCTGAAAGGAAATTCTGGGTCTTGAAAGGAGTGTATTCAACTCAAGTTGGT
TTTGCAGGAGGCTATACTTCAAATCCTACTTATAAAGAAGTCTGCTCAGAAAGAAGAGATTTTATCGACATCGAAAGTAAATTTGCCCTA
AGGACCCCTGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGTGGCTACCTGTCATTTCAATCACAGCAGC
AAAACCTTCATGGTGATCCATGGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTACAAGAGAGAA
CCAGACTCCAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTCCGCGGGCTACACCAAACTGGTGGGACAG
GATGTGGCCCGGTTTATCAACTGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTTGGAGCCCAT
GCTGCTGGCATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCCAGCTGGACCTAACTTTGAGTATGCAGAA
GCCCCGAGTCGTCTTTCTCCTGATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGCATTGGAATC
CAGAAACCAGTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAGCCAGGATGTAACATTGGAGAAGCTATCCGCGTGATTGCA
GAGAGAGGACTTGGAGATGTGGACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTGAATGAAGAA
AATCCAAGTAAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGGCTCTGCTTGAGTTGTAGAAAGAACCGCTGCAACAATCTG
GGCTATGAGATCAATAAAGTCAGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTCTTCCATTAC
CAAGTAAAGATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAGGCCTTTGAGATTTCTCTGTATGGCACCGTGGCCGAGAGT
GAGAACATCCCATTCACTCTGCCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTACACAGAGGTAGATATTGGAGAACTACTC
ATGTTGAAGCTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGGTGGAGCAGTCCCGGCTTCGCCATTCAGAAGATCAGAGTA
AAAGCAGGAGAGACTCAGAAAAAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCGGTATTTGTG
AAATGCCATGACAAGTCTCTGAATAAGAAGTCAGGCTGAAACTGGGCGAATCTACAGAACAAAGAACGGCATGTGAATTCTGTGAAGAAT
GAAGTGGAGGAAGTAACTTTTACAAAACATACCCAGTGTTTGGGGTGTTTCAAAAGTGGATTTTCCTGAATATTAATCCCAGCCCTACCC
TTGTTAGTTATTTTAGGAGACAGTCTCAAGCACTAAAAAGTGGCTAATTCAATTTATGGGGTATAGTGGCCAAATAGCACATCCTCCAAC
GTTAAAAGACAGTGGATCATGAAAAGTGCTGTTTTGTCCTTTGAGAAAGAAATAATTGTTTGAGCGCAGAGTAAAATAAGGCTCCTTCAT
GTGGCGTATTGGGCCATAGCCTATAATTGGTTAGAACCTCCTATTTTAATTGGAATTCTGGATCTTTCGGACTGAGGCCTTCTCAAACTT
TACTCTAAGTCTCCAAGAATACAGAAAATGCTTTTCCGCGGCACGAATCAGACTCATCTACACAGCAGTATGAATGATGTTTTAGAATGA
TTCCCTCTTGCTATTGGAATGTGGTCCAGACGTCAACCAGGAACATGTAACTTGGAGAGGGACGAAGAAAGGGTCTGATAAACACAGAGG
TTTTAAACAGTCCCTACCATTGGCCTGCATCATGACAAAGTTACAAATTCAAGGAGATATAAAATCTAGATCAATTAATTCTTAATAGGC
TTTATCGTTTATTGCTTAATCCCTCTCTCCCCCTTCTTTTTTGTCTCAAGATTATATTATAATAATGTTCTCTGGGTAGGTGTTGAAAAT
GAGCCTGTAATCCTCAGCTGACACATAATTTGAATGGTGCAGAAAAAAAAAAAGAAACCGTAATTTTATTATTAGATTCTCCAAATGATT
TTCATCAATTTAAAATCATTCAATATCTGACAGTTACTCTTCAGTTTTAGGCTTACCTTGGTCATGCTTCAGTTGTACTTCCAGTGCGTC
TCTTTTGTTCCTGGCTTTGACATGAAAAGATAGGTTTGAGTTCAAATTTTGCATTGTGTGAGCTTCTACAGATTTTAGACAAGGACCGTT
TTTACTAAGTAAAAGGGTGGAGAGGTTCCTGGGGTGGATTCCTAAGCAGTGCTTGTAAACCATCGCGTGCAATGAGCCAGATGGAGTACC
ATGAGGGTTGCTATTTGTTGTTTTTAACAACTAATCAAGAGTGAGTGAACAACTATTTATAAACTAGATCTCCTATTTTTCAGAATGCTC
TTCTACGTATAAATATGAAATGATAAAGATGTCAAATATCTCAGAGGCTATAGCTGGGAACCCGACTGTGAAAGTATGTGATATCTGAAC
ACATACTAGAAAGCTCTGCATGTGTGTTGTCCTTCAGCATAATTCGGAAGGGAAAACAGTCGATCAAGGGATGTATTGGAACATGTCGGA
GTAGAAATTGTTCCTGATGTGCCAGAACTTCGACCCTTTCTCTGAGAGAGATGATCGTGCCTATAAATAGTAGGACCAATGTTGTGATTA
ACATCATCAGGCTTGGAATGAATTCTCTCTAAAAATAAAATGATGTATGATTTGTTGTTGGCATCCCCTTTATTAATTCATTAAATTTCT
GGATTTGGGTTGTGACCCAGGGTGCATTAACTTAAAAGATTCACTAAAGCAGCACATAGCACTGGGAACTCTGGCTCCGAAAAACTTTGT
TATATATATCAAGGATGTTCTGGCTTTACATTTTATTTATTAGCTGTAAATACATGTGTGGATGTGTAAATGGAGCTTGTACATATTGGA
AAGGTCATTGTGGCTATCTGCATTTATAAATGTGTGGTGCTAACTGTATGTGTCTTTATCAGTGATGGTCTCACAGAGCCAACTCACTCT
TATGAAATGGGCTTTAACAAAACAAGAAAGAAACGTACTTAACTGTGTGAAGAAATGGAATCAGCTTTTAATAAAATTGACAACATTTTA

>In-frame_ENST00000521209_ENST00000311322_TCGA-VQ-A91N_MSRA_chr8_10102733_+_LPL_chr8_19805690_length(amino acids)=490AA_start in transcript=186_stop in transcript=1658
MAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSERRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKT
FMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAA
GIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAER
GLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQV
KIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKA

--------------------------------------------------------------
>In-frame_ENST00000528246_ENST00000311322_TCGA-VQ-A91N_MSRA_chr8_10102733_+_LPL_chr8_19805690_length(transcript)=4044nt_BP=756nt
GAGTGAGAGAGAGAAAGAGGGAGAGAGAGAGGCAGAGGGAGAGCTGAGGAAAGAAAAAAAGGCAAGACTTGGCACAGCTCAGTCAAATCA
GCTTCTTTTGTCTGCTTTCTCGGCTTGAGCTTCAGGAAAGAAAACCGTCCTGGGGTACAGAAAAACTCAGAACTTTTTGGTTTTCAAACT
TAGAAGGCTTTTTAAGTCTCTTGGGCTATTTGAAAGTGTTGGTACATACAATGACGTTTAGTCACCAGTATTAAGGGAAATAAAAGCCTT
TTTCAAAACGAAGCTTCCATAGTGTCCATGCATTTGGGAAATACTATATTTGATTTTTTGCATGTATGATTATACCATGAGAGACAGGAT
TAATATAGAAGATGGCAAGGCAAATTTCTAATTAGAGGGAATATTAATTTTCTACAAAATAAAGTTTGTTCATCAATACAAACCTGCTTT
CAAATCAAATCAGAAAGACATCCTTCGGAATGTGTTCAGAACCAATTAGTGACAACACTGAAGACCAGAAAGGCAAGCTGAAGACACCAG
ACTTCGCTTGAAGGGCAAACAAGAAATCCAAACATCATGTCAATGGCAACAGAACAGTCGAACCTTTCCCAGAGGGAACACAGATGGCTG
TATTTGGAATGGGATGTTTCTGGGGAGCTGAAAGGAAATTCTGGGTCTTGAAAGGAGTGTATTCAACTCAAGTTGGTTTTGCAGGAGGCT
ATACTTCAAATCCTACTTATAAAGAAGTCTGCTCAGAAAGAAGAGATTTTATCGACATCGAAAGTAAATTTGCCCTAAGGACCCCTGAAG
ACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGTGGCTACCTGTCATTTCAATCACAGCAGCAAAACCTTCATGG
TGATCCATGGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTACAAGAGAGAACCAGACTCCAATG
TCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTCCGCGGGCTACACCAAACTGGTGGGACAGGATGTGGCCCGGT
TTATCAACTGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTTGGAGCCCATGCTGCTGGCATTG
CAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCCAGCTGGACCTAACTTTGAGTATGCAGAAGCCCCGAGTCGTC
TTTCTCCTGATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGCATTGGAATCCAGAAACCAGTTG
GGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAGCCAGGATGTAACATTGGAGAAGCTATCCGCGTGATTGCAGAGAGAGGACTTG
GAGATGTGGACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTGAATGAAGAAAATCCAAGTAAGG
CCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGGCTCTGCTTGAGTTGTAGAAAGAACCGCTGCAACAATCTGGGCTATGAGATCA
ATAAAGTCAGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTCTTCCATTACCAAGTAAAGATTC
ATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAGGCCTTTGAGATTTCTCTGTATGGCACCGTGGCCGAGAGTGAGAACATCCCAT
TCACTCTGCCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTACACAGAGGTAGATATTGGAGAACTACTCATGTTGAAGCTCA
AATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGGTGGAGCAGTCCCGGCTTCGCCATTCAGAAGATCAGAGTAAAAGCAGGAGAGA
CTCAGAAAAAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCGGTATTTGTGAAATGCCATGACA
AGTCTCTGAATAAGAAGTCAGGCTGAAACTGGGCGAATCTACAGAACAAAGAACGGCATGTGAATTCTGTGAAGAATGAAGTGGAGGAAG
TAACTTTTACAAAACATACCCAGTGTTTGGGGTGTTTCAAAAGTGGATTTTCCTGAATATTAATCCCAGCCCTACCCTTGTTAGTTATTT
TAGGAGACAGTCTCAAGCACTAAAAAGTGGCTAATTCAATTTATGGGGTATAGTGGCCAAATAGCACATCCTCCAACGTTAAAAGACAGT
GGATCATGAAAAGTGCTGTTTTGTCCTTTGAGAAAGAAATAATTGTTTGAGCGCAGAGTAAAATAAGGCTCCTTCATGTGGCGTATTGGG
CCATAGCCTATAATTGGTTAGAACCTCCTATTTTAATTGGAATTCTGGATCTTTCGGACTGAGGCCTTCTCAAACTTTACTCTAAGTCTC
CAAGAATACAGAAAATGCTTTTCCGCGGCACGAATCAGACTCATCTACACAGCAGTATGAATGATGTTTTAGAATGATTCCCTCTTGCTA
TTGGAATGTGGTCCAGACGTCAACCAGGAACATGTAACTTGGAGAGGGACGAAGAAAGGGTCTGATAAACACAGAGGTTTTAAACAGTCC
CTACCATTGGCCTGCATCATGACAAAGTTACAAATTCAAGGAGATATAAAATCTAGATCAATTAATTCTTAATAGGCTTTATCGTTTATT
GCTTAATCCCTCTCTCCCCCTTCTTTTTTGTCTCAAGATTATATTATAATAATGTTCTCTGGGTAGGTGTTGAAAATGAGCCTGTAATCC
TCAGCTGACACATAATTTGAATGGTGCAGAAAAAAAAAAAGAAACCGTAATTTTATTATTAGATTCTCCAAATGATTTTCATCAATTTAA
AATCATTCAATATCTGACAGTTACTCTTCAGTTTTAGGCTTACCTTGGTCATGCTTCAGTTGTACTTCCAGTGCGTCTCTTTTGTTCCTG
GCTTTGACATGAAAAGATAGGTTTGAGTTCAAATTTTGCATTGTGTGAGCTTCTACAGATTTTAGACAAGGACCGTTTTTACTAAGTAAA
AGGGTGGAGAGGTTCCTGGGGTGGATTCCTAAGCAGTGCTTGTAAACCATCGCGTGCAATGAGCCAGATGGAGTACCATGAGGGTTGCTA
TTTGTTGTTTTTAACAACTAATCAAGAGTGAGTGAACAACTATTTATAAACTAGATCTCCTATTTTTCAGAATGCTCTTCTACGTATAAA
TATGAAATGATAAAGATGTCAAATATCTCAGAGGCTATAGCTGGGAACCCGACTGTGAAAGTATGTGATATCTGAACACATACTAGAAAG
CTCTGCATGTGTGTTGTCCTTCAGCATAATTCGGAAGGGAAAACAGTCGATCAAGGGATGTATTGGAACATGTCGGAGTAGAAATTGTTC
CTGATGTGCCAGAACTTCGACCCTTTCTCTGAGAGAGATGATCGTGCCTATAAATAGTAGGACCAATGTTGTGATTAACATCATCAGGCT
TGGAATGAATTCTCTCTAAAAATAAAATGATGTATGATTTGTTGTTGGCATCCCCTTTATTAATTCATTAAATTTCTGGATTTGGGTTGT
GACCCAGGGTGCATTAACTTAAAAGATTCACTAAAGCAGCACATAGCACTGGGAACTCTGGCTCCGAAAAACTTTGTTATATATATCAAG
GATGTTCTGGCTTTACATTTTATTTATTAGCTGTAAATACATGTGTGGATGTGTAAATGGAGCTTGTACATATTGGAAAGGTCATTGTGG
CTATCTGCATTTATAAATGTGTGGTGCTAACTGTATGTGTCTTTATCAGTGATGGTCTCACAGAGCCAACTCACTCTTATGAAATGGGCT

>In-frame_ENST00000528246_ENST00000311322_TCGA-VQ-A91N_MSRA_chr8_10102733_+_LPL_chr8_19805690_length(amino acids)=490AA_start in transcript=623_stop in transcript=2095
MAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSERRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKT
FMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAA
GIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAER
GLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQV
KIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKA

--------------------------------------------------------------
>In-frame_ENST00000382490_ENST00000311322_TCGA-VQ-A91N_MSRA_chr8_10102733_+_LPL_chr8_19805690_length(transcript)=3794nt_BP=506nt
AAACTTAGAAGGCTTTTTAAGTCTCTTGGGCTATTTGAAAGTGTTGGTACATACAATGACGTTTAGTCACCAGTATTAAGGGAAATAAAA
GCCTTTTTCAAAACGAAGCTTCCATAGTGTCCATGCATTTGGGAAATACTATATTTGATTTTTTGCATGTATGATTATACCATGAGAGAC
AGGATTAATATAGAAGATGGCAAGGCAAATTTCTAATTAGAGGGAATATTAATTTTCTACAAAATAAAGTTTGTTCATCAATACAAACCT
GCTTTCAAATCAAATCAGAAAGACATCCTTCGGAATGTGTTCAGAACCCAAACATCATGTCAATGGCAACAGAACAGTCGAACCTTTCCC
AGAGGGAACACAGATGGCTGTATTTGGAATGGGATGTTTCTGGGGAGCTGAAAGGAAATTCTGGGTCTTGAAAGGAGTGTATTCAACTCA
AGTTGGTTTTGCAGGAGGCTATACTTCAAATCCTACTTATAAAGAAGTCTGCTCAGAAAGAAGAGATTTTATCGACATCGAAAGTAAATT
TGCCCTAAGGACCCCTGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGTGGCTACCTGTCATTTCAATCA
CAGCAGCAAAACCTTCATGGTGATCCATGGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTACAA
GAGAGAACCAGACTCCAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTCCGCGGGCTACACCAAACTGGT
GGGACAGGATGTGGCCCGGTTTATCAACTGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTTGG
AGCCCATGCTGCTGGCATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCCAGCTGGACCTAACTTTGAGTA
TGCAGAAGCCCCGAGTCGTCTTTCTCCTGATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGCAT
TGGAATCCAGAAACCAGTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAGCCAGGATGTAACATTGGAGAAGCTATCCGCGT
GATTGCAGAGAGAGGACTTGGAGATGTGGACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTGAA
TGAAGAAAATCCAAGTAAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGGCTCTGCTTGAGTTGTAGAAAGAACCGCTGCAA
CAATCTGGGCTATGAGATCAATAAAGTCAGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTCTT
CCATTACCAAGTAAAGATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAGGCCTTTGAGATTTCTCTGTATGGCACCGTGGC
CGAGAGTGAGAACATCCCATTCACTCTGCCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTACACAGAGGTAGATATTGGAGA
ACTACTCATGTTGAAGCTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGGTGGAGCAGTCCCGGCTTCGCCATTCAGAAGAT
CAGAGTAAAAGCAGGAGAGACTCAGAAAAAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCGGT
ATTTGTGAAATGCCATGACAAGTCTCTGAATAAGAAGTCAGGCTGAAACTGGGCGAATCTACAGAACAAAGAACGGCATGTGAATTCTGT
GAAGAATGAAGTGGAGGAAGTAACTTTTACAAAACATACCCAGTGTTTGGGGTGTTTCAAAAGTGGATTTTCCTGAATATTAATCCCAGC
CCTACCCTTGTTAGTTATTTTAGGAGACAGTCTCAAGCACTAAAAAGTGGCTAATTCAATTTATGGGGTATAGTGGCCAAATAGCACATC
CTCCAACGTTAAAAGACAGTGGATCATGAAAAGTGCTGTTTTGTCCTTTGAGAAAGAAATAATTGTTTGAGCGCAGAGTAAAATAAGGCT
CCTTCATGTGGCGTATTGGGCCATAGCCTATAATTGGTTAGAACCTCCTATTTTAATTGGAATTCTGGATCTTTCGGACTGAGGCCTTCT
CAAACTTTACTCTAAGTCTCCAAGAATACAGAAAATGCTTTTCCGCGGCACGAATCAGACTCATCTACACAGCAGTATGAATGATGTTTT
AGAATGATTCCCTCTTGCTATTGGAATGTGGTCCAGACGTCAACCAGGAACATGTAACTTGGAGAGGGACGAAGAAAGGGTCTGATAAAC
ACAGAGGTTTTAAACAGTCCCTACCATTGGCCTGCATCATGACAAAGTTACAAATTCAAGGAGATATAAAATCTAGATCAATTAATTCTT
AATAGGCTTTATCGTTTATTGCTTAATCCCTCTCTCCCCCTTCTTTTTTGTCTCAAGATTATATTATAATAATGTTCTCTGGGTAGGTGT
TGAAAATGAGCCTGTAATCCTCAGCTGACACATAATTTGAATGGTGCAGAAAAAAAAAAAGAAACCGTAATTTTATTATTAGATTCTCCA
AATGATTTTCATCAATTTAAAATCATTCAATATCTGACAGTTACTCTTCAGTTTTAGGCTTACCTTGGTCATGCTTCAGTTGTACTTCCA
GTGCGTCTCTTTTGTTCCTGGCTTTGACATGAAAAGATAGGTTTGAGTTCAAATTTTGCATTGTGTGAGCTTCTACAGATTTTAGACAAG
GACCGTTTTTACTAAGTAAAAGGGTGGAGAGGTTCCTGGGGTGGATTCCTAAGCAGTGCTTGTAAACCATCGCGTGCAATGAGCCAGATG
GAGTACCATGAGGGTTGCTATTTGTTGTTTTTAACAACTAATCAAGAGTGAGTGAACAACTATTTATAAACTAGATCTCCTATTTTTCAG
AATGCTCTTCTACGTATAAATATGAAATGATAAAGATGTCAAATATCTCAGAGGCTATAGCTGGGAACCCGACTGTGAAAGTATGTGATA
TCTGAACACATACTAGAAAGCTCTGCATGTGTGTTGTCCTTCAGCATAATTCGGAAGGGAAAACAGTCGATCAAGGGATGTATTGGAACA
TGTCGGAGTAGAAATTGTTCCTGATGTGCCAGAACTTCGACCCTTTCTCTGAGAGAGATGATCGTGCCTATAAATAGTAGGACCAATGTT
GTGATTAACATCATCAGGCTTGGAATGAATTCTCTCTAAAAATAAAATGATGTATGATTTGTTGTTGGCATCCCCTTTATTAATTCATTA
AATTTCTGGATTTGGGTTGTGACCCAGGGTGCATTAACTTAAAAGATTCACTAAAGCAGCACATAGCACTGGGAACTCTGGCTCCGAAAA
ACTTTGTTATATATATCAAGGATGTTCTGGCTTTACATTTTATTTATTAGCTGTAAATACATGTGTGGATGTGTAAATGGAGCTTGTACA
TATTGGAAAGGTCATTGTGGCTATCTGCATTTATAAATGTGTGGTGCTAACTGTATGTGTCTTTATCAGTGATGGTCTCACAGAGCCAAC
TCACTCTTATGAAATGGGCTTTAACAAAACAAGAAAGAAACGTACTTAACTGTGTGAAGAAATGGAATCAGCTTTTAATAAAATTGACAA

>In-frame_ENST00000382490_ENST00000311322_TCGA-VQ-A91N_MSRA_chr8_10102733_+_LPL_chr8_19805690_length(amino acids)=531AA_start in transcript=250_stop in transcript=1845
MFINTNLLSNQIRKTSFGMCSEPKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSERRDF
IDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVS
AGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTR
GSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLS
CRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIY

--------------------------------------------------------------
>In-frame_ENST00000317173_ENST00000311322_TCGA-VQ-A91N-01A_MSRA_chr8_10102733_+_LPL_chr8_19805691_length(transcript)=3868nt_BP=580nt
GGAACTCGCCGGGCCACACCCCCTGTCCAGGGAAGGAACACGCCCCCGGTGACAGCCGGTACGGCCCCGGGTTTGGGCAACCTCGATTAC
GGGCGGCCTCCAGCCCCGCCAGCAGCGCCCCGCGCCCGCCCGCCCGCGCCCCTGCCGCCCCCCGGTTCCGGCCGCGGACCCCACTCTCTG
CCGTTCCGGCTGCGGCTCCGCTGCCGGTAGCGCCGTCCCCCGGGACCACCCTTCGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGG
GCTTGCCAGCTCCTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAACTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTG
CCGGGCCGGAAGGAACAGACCCCTGTAGCGGCCAAACATCATGTCAATGGCAACAGAACAGTCGAACCTTTCCCAGAGGGAACACAGATG
GCTGTATTTGGAATGGGATGTTTCTGGGGAGCTGAAAGGAAATTCTGGGTCTTGAAAGGAGTGTATTCAACTCAAGTTGGTTTTGCAGGA
GGCTATACTTCAAATCCTACTTATAAAGAAGTCTGCTCAGAAAGAAGAGATTTTATCGACATCGAAAGTAAATTTGCCCTAAGGACCCCT
GAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGTGGCTACCTGTCATTTCAATCACAGCAGCAAAACCTTC
ATGGTGATCCATGGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTACAAGAGAGAACCAGACTCC
AATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTCCGCGGGCTACACCAAACTGGTGGGACAGGATGTGGCC
CGGTTTATCAACTGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTTGGAGCCCATGCTGCTGGC
ATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCCAGCTGGACCTAACTTTGAGTATGCAGAAGCCCCGAGT
CGTCTTTCTCCTGATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGCATTGGAATCCAGAAACCA
GTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAGCCAGGATGTAACATTGGAGAAGCTATCCGCGTGATTGCAGAGAGAGGA
CTTGGAGATGTGGACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTGAATGAAGAAAATCCAAGT
AAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGGCTCTGCTTGAGTTGTAGAAAGAACCGCTGCAACAATCTGGGCTATGAG
ATCAATAAAGTCAGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTCTTCCATTACCAAGTAAAG
ATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAGGCCTTTGAGATTTCTCTGTATGGCACCGTGGCCGAGAGTGAGAACATC
CCATTCACTCTGCCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTACACAGAGGTAGATATTGGAGAACTACTCATGTTGAAG
CTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGGTGGAGCAGTCCCGGCTTCGCCATTCAGAAGATCAGAGTAAAAGCAGGA
GAGACTCAGAAAAAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCGGTATTTGTGAAATGCCAT
GACAAGTCTCTGAATAAGAAGTCAGGCTGAAACTGGGCGAATCTACAGAACAAAGAACGGCATGTGAATTCTGTGAAGAATGAAGTGGAG
GAAGTAACTTTTACAAAACATACCCAGTGTTTGGGGTGTTTCAAAAGTGGATTTTCCTGAATATTAATCCCAGCCCTACCCTTGTTAGTT
ATTTTAGGAGACAGTCTCAAGCACTAAAAAGTGGCTAATTCAATTTATGGGGTATAGTGGCCAAATAGCACATCCTCCAACGTTAAAAGA
CAGTGGATCATGAAAAGTGCTGTTTTGTCCTTTGAGAAAGAAATAATTGTTTGAGCGCAGAGTAAAATAAGGCTCCTTCATGTGGCGTAT
TGGGCCATAGCCTATAATTGGTTAGAACCTCCTATTTTAATTGGAATTCTGGATCTTTCGGACTGAGGCCTTCTCAAACTTTACTCTAAG
TCTCCAAGAATACAGAAAATGCTTTTCCGCGGCACGAATCAGACTCATCTACACAGCAGTATGAATGATGTTTTAGAATGATTCCCTCTT
GCTATTGGAATGTGGTCCAGACGTCAACCAGGAACATGTAACTTGGAGAGGGACGAAGAAAGGGTCTGATAAACACAGAGGTTTTAAACA
GTCCCTACCATTGGCCTGCATCATGACAAAGTTACAAATTCAAGGAGATATAAAATCTAGATCAATTAATTCTTAATAGGCTTTATCGTT
TATTGCTTAATCCCTCTCTCCCCCTTCTTTTTTGTCTCAAGATTATATTATAATAATGTTCTCTGGGTAGGTGTTGAAAATGAGCCTGTA
ATCCTCAGCTGACACATAATTTGAATGGTGCAGAAAAAAAAAAAGAAACCGTAATTTTATTATTAGATTCTCCAAATGATTTTCATCAAT
TTAAAATCATTCAATATCTGACAGTTACTCTTCAGTTTTAGGCTTACCTTGGTCATGCTTCAGTTGTACTTCCAGTGCGTCTCTTTTGTT
CCTGGCTTTGACATGAAAAGATAGGTTTGAGTTCAAATTTTGCATTGTGTGAGCTTCTACAGATTTTAGACAAGGACCGTTTTTACTAAG
TAAAAGGGTGGAGAGGTTCCTGGGGTGGATTCCTAAGCAGTGCTTGTAAACCATCGCGTGCAATGAGCCAGATGGAGTACCATGAGGGTT
GCTATTTGTTGTTTTTAACAACTAATCAAGAGTGAGTGAACAACTATTTATAAACTAGATCTCCTATTTTTCAGAATGCTCTTCTACGTA
TAAATATGAAATGATAAAGATGTCAAATATCTCAGAGGCTATAGCTGGGAACCCGACTGTGAAAGTATGTGATATCTGAACACATACTAG
AAAGCTCTGCATGTGTGTTGTCCTTCAGCATAATTCGGAAGGGAAAACAGTCGATCAAGGGATGTATTGGAACATGTCGGAGTAGAAATT
GTTCCTGATGTGCCAGAACTTCGACCCTTTCTCTGAGAGAGATGATCGTGCCTATAAATAGTAGGACCAATGTTGTGATTAACATCATCA
GGCTTGGAATGAATTCTCTCTAAAAATAAAATGATGTATGATTTGTTGTTGGCATCCCCTTTATTAATTCATTAAATTTCTGGATTTGGG
TTGTGACCCAGGGTGCATTAACTTAAAAGATTCACTAAAGCAGCACATAGCACTGGGAACTCTGGCTCCGAAAAACTTTGTTATATATAT
CAAGGATGTTCTGGCTTTACATTTTATTTATTAGCTGTAAATACATGTGTGGATGTGTAAATGGAGCTTGTACATATTGGAAAGGTCATT
GTGGCTATCTGCATTTATAAATGTGTGGTGCTAACTGTATGTGTCTTTATCAGTGATGGTCTCACAGAGCCAACTCACTCTTATGAAATG

>In-frame_ENST00000317173_ENST00000311322_TCGA-VQ-A91N-01A_MSRA_chr8_10102733_+_LPL_chr8_19805691_length(amino acids)=556AA_start in transcript=249_stop in transcript=1919
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYS
TQVGFAGGYTSNPTYKEVCSERRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAAL
YKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNF
EYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSL
LNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGT
VAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAP

--------------------------------------------------------------
>In-frame_ENST00000518255_ENST00000311322_TCGA-VQ-A91N-01A_MSRA_chr8_10102733_+_LPL_chr8_19805691_length(transcript)=3635nt_BP=347nt
CGGCTGGCGCCCTCCCATGCTCTCGGCCACCCGGAGGGCTTGCCAGCTCCTCCTCCTCCACAGCCTCTTTCCCGTCCCGAGGATGGGCAA
CTCGGCCTCGAACATCGTCAGCCCCCAGGAGGCCTTGCCGGGCCGGAAGGAACAGACCCCTGTAGCGGCCAAACATCATGTCAATGGCAA
CAGAACAGTCGAACCTTTCCCAGAGGGAACACAGATGGCTGTATTTGGAATGGGATGTTTCTGGGGAGCTGAAAGGAAATTCTGGGTCTT
GAAAGGAGTGTATTCAACTCAAGTTGGTTTTGCAGGAGGCTATACTTCAAATCCTACTTATAAAGAAGTCTGCTCAGAAAGAAGAGATTT
TATCGACATCGAAAGTAAATTTGCCCTAAGGACCCCTGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGT
GGCTACCTGTCATTTCAATCACAGCAGCAAAACCTTCATGGTGATCCATGGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAA
ACTTGTGGCCGCCCTGTACAAGAGAGAACCAGACTCCAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTC
CGCGGGCTACACCAAACTGGTGGGACAGGATGTGGCCCGGTTTATCAACTGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCA
TCTCTTGGGATACAGCCTTGGAGCCCATGCTGCTGGCATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCC
AGCTGGACCTAACTTTGAGTATGCAGAAGCCCCGAGTCGTCTTTCTCCTGATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAG
AGGGTCCCCTGGTCGAAGCATTGGAATCCAGAAACCAGTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAGCCAGGATGTAA
CATTGGAGAAGCTATCCGCGTGATTGCAGAGAGAGGACTTGGAGATGTGGACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCT
CTTCATCGACTCTCTGTTGAATGAAGAAAATCCAAGTAAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGGCTCTGCTTGAG
TTGTAGAAAGAACCGCTGCAACAATCTGGGCTATGAGATCAATAAAGTCAGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTC
TCAGATGCCCTACAAAGTCTTCCATTACCAAGTAAAGATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAGGCCTTTGAGAT
TTCTCTGTATGGCACCGTGGCCGAGAGTGAGAACATCCCATTCACTCTGCCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTA
CACAGAGGTAGATATTGGAGAACTACTCATGTTGAAGCTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGGTGGAGCAGTCC
CGGCTTCGCCATTCAGAAGATCAGAGTAAAAGCAGGAGAGACTCAGAAAAAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCA
GAAAGGAAAGGCACCTGCGGTATTTGTGAAATGCCATGACAAGTCTCTGAATAAGAAGTCAGGCTGAAACTGGGCGAATCTACAGAACAA
AGAACGGCATGTGAATTCTGTGAAGAATGAAGTGGAGGAAGTAACTTTTACAAAACATACCCAGTGTTTGGGGTGTTTCAAAAGTGGATT
TTCCTGAATATTAATCCCAGCCCTACCCTTGTTAGTTATTTTAGGAGACAGTCTCAAGCACTAAAAAGTGGCTAATTCAATTTATGGGGT
ATAGTGGCCAAATAGCACATCCTCCAACGTTAAAAGACAGTGGATCATGAAAAGTGCTGTTTTGTCCTTTGAGAAAGAAATAATTGTTTG
AGCGCAGAGTAAAATAAGGCTCCTTCATGTGGCGTATTGGGCCATAGCCTATAATTGGTTAGAACCTCCTATTTTAATTGGAATTCTGGA
TCTTTCGGACTGAGGCCTTCTCAAACTTTACTCTAAGTCTCCAAGAATACAGAAAATGCTTTTCCGCGGCACGAATCAGACTCATCTACA
CAGCAGTATGAATGATGTTTTAGAATGATTCCCTCTTGCTATTGGAATGTGGTCCAGACGTCAACCAGGAACATGTAACTTGGAGAGGGA
CGAAGAAAGGGTCTGATAAACACAGAGGTTTTAAACAGTCCCTACCATTGGCCTGCATCATGACAAAGTTACAAATTCAAGGAGATATAA
AATCTAGATCAATTAATTCTTAATAGGCTTTATCGTTTATTGCTTAATCCCTCTCTCCCCCTTCTTTTTTGTCTCAAGATTATATTATAA
TAATGTTCTCTGGGTAGGTGTTGAAAATGAGCCTGTAATCCTCAGCTGACACATAATTTGAATGGTGCAGAAAAAAAAAAAGAAACCGTA
ATTTTATTATTAGATTCTCCAAATGATTTTCATCAATTTAAAATCATTCAATATCTGACAGTTACTCTTCAGTTTTAGGCTTACCTTGGT
CATGCTTCAGTTGTACTTCCAGTGCGTCTCTTTTGTTCCTGGCTTTGACATGAAAAGATAGGTTTGAGTTCAAATTTTGCATTGTGTGAG
CTTCTACAGATTTTAGACAAGGACCGTTTTTACTAAGTAAAAGGGTGGAGAGGTTCCTGGGGTGGATTCCTAAGCAGTGCTTGTAAACCA
TCGCGTGCAATGAGCCAGATGGAGTACCATGAGGGTTGCTATTTGTTGTTTTTAACAACTAATCAAGAGTGAGTGAACAACTATTTATAA
ACTAGATCTCCTATTTTTCAGAATGCTCTTCTACGTATAAATATGAAATGATAAAGATGTCAAATATCTCAGAGGCTATAGCTGGGAACC
CGACTGTGAAAGTATGTGATATCTGAACACATACTAGAAAGCTCTGCATGTGTGTTGTCCTTCAGCATAATTCGGAAGGGAAAACAGTCG
ATCAAGGGATGTATTGGAACATGTCGGAGTAGAAATTGTTCCTGATGTGCCAGAACTTCGACCCTTTCTCTGAGAGAGATGATCGTGCCT
ATAAATAGTAGGACCAATGTTGTGATTAACATCATCAGGCTTGGAATGAATTCTCTCTAAAAATAAAATGATGTATGATTTGTTGTTGGC
ATCCCCTTTATTAATTCATTAAATTTCTGGATTTGGGTTGTGACCCAGGGTGCATTAACTTAAAAGATTCACTAAAGCAGCACATAGCAC
TGGGAACTCTGGCTCCGAAAAACTTTGTTATATATATCAAGGATGTTCTGGCTTTACATTTTATTTATTAGCTGTAAATACATGTGTGGA
TGTGTAAATGGAGCTTGTACATATTGGAAAGGTCATTGTGGCTATCTGCATTTATAAATGTGTGGTGCTAACTGTATGTGTCTTTATCAG
TGATGGTCTCACAGAGCCAACTCACTCTTATGAAATGGGCTTTAACAAAACAAGAAAGAAACGTACTTAACTGTGTGAAGAAATGGAATC

>In-frame_ENST00000518255_ENST00000311322_TCGA-VQ-A91N-01A_MSRA_chr8_10102733_+_LPL_chr8_19805691_length(amino acids)=556AA_start in transcript=16_stop in transcript=1686
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYS
TQVGFAGGYTSNPTYKEVCSERRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAAL
YKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNF
EYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSL
LNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGT
VAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAP

--------------------------------------------------------------
>In-frame_ENST00000521209_ENST00000311322_TCGA-VQ-A91N-01A_MSRA_chr8_10102733_+_LPL_chr8_19805691_length(transcript)=3607nt_BP=319nt
TGAATGATAGATTATTATTTTACATTGTAGGTACAGCCAGTGTGATCAGACAAAGCAATTCGAGAACTACAAAAGAGGAAAAAAGATCAG
AAGTTCTTAAATACATAAGGGAATGCAGCATTTGATAAAGCCAAACATCATGTCAATGGCAACAGAACAGTCGAACCTTTCCCAGAGGGA
ACACAGATGGCTGTATTTGGAATGGGATGTTTCTGGGGAGCTGAAAGGAAATTCTGGGTCTTGAAAGGAGTGTATTCAACTCAAGTTGGT
TTTGCAGGAGGCTATACTTCAAATCCTACTTATAAAGAAGTCTGCTCAGAAAGAAGAGATTTTATCGACATCGAAAGTAAATTTGCCCTA
AGGACCCCTGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGTGGCTACCTGTCATTTCAATCACAGCAGC
AAAACCTTCATGGTGATCCATGGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTACAAGAGAGAA
CCAGACTCCAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTCCGCGGGCTACACCAAACTGGTGGGACAG
GATGTGGCCCGGTTTATCAACTGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTTGGAGCCCAT
GCTGCTGGCATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCCAGCTGGACCTAACTTTGAGTATGCAGAA
GCCCCGAGTCGTCTTTCTCCTGATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGCATTGGAATC
CAGAAACCAGTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAGCCAGGATGTAACATTGGAGAAGCTATCCGCGTGATTGCA
GAGAGAGGACTTGGAGATGTGGACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTGAATGAAGAA
AATCCAAGTAAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGGCTCTGCTTGAGTTGTAGAAAGAACCGCTGCAACAATCTG
GGCTATGAGATCAATAAAGTCAGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTCTTCCATTAC
CAAGTAAAGATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAGGCCTTTGAGATTTCTCTGTATGGCACCGTGGCCGAGAGT
GAGAACATCCCATTCACTCTGCCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTACACAGAGGTAGATATTGGAGAACTACTC
ATGTTGAAGCTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGGTGGAGCAGTCCCGGCTTCGCCATTCAGAAGATCAGAGTA
AAAGCAGGAGAGACTCAGAAAAAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCGGTATTTGTG
AAATGCCATGACAAGTCTCTGAATAAGAAGTCAGGCTGAAACTGGGCGAATCTACAGAACAAAGAACGGCATGTGAATTCTGTGAAGAAT
GAAGTGGAGGAAGTAACTTTTACAAAACATACCCAGTGTTTGGGGTGTTTCAAAAGTGGATTTTCCTGAATATTAATCCCAGCCCTACCC
TTGTTAGTTATTTTAGGAGACAGTCTCAAGCACTAAAAAGTGGCTAATTCAATTTATGGGGTATAGTGGCCAAATAGCACATCCTCCAAC
GTTAAAAGACAGTGGATCATGAAAAGTGCTGTTTTGTCCTTTGAGAAAGAAATAATTGTTTGAGCGCAGAGTAAAATAAGGCTCCTTCAT
GTGGCGTATTGGGCCATAGCCTATAATTGGTTAGAACCTCCTATTTTAATTGGAATTCTGGATCTTTCGGACTGAGGCCTTCTCAAACTT
TACTCTAAGTCTCCAAGAATACAGAAAATGCTTTTCCGCGGCACGAATCAGACTCATCTACACAGCAGTATGAATGATGTTTTAGAATGA
TTCCCTCTTGCTATTGGAATGTGGTCCAGACGTCAACCAGGAACATGTAACTTGGAGAGGGACGAAGAAAGGGTCTGATAAACACAGAGG
TTTTAAACAGTCCCTACCATTGGCCTGCATCATGACAAAGTTACAAATTCAAGGAGATATAAAATCTAGATCAATTAATTCTTAATAGGC
TTTATCGTTTATTGCTTAATCCCTCTCTCCCCCTTCTTTTTTGTCTCAAGATTATATTATAATAATGTTCTCTGGGTAGGTGTTGAAAAT
GAGCCTGTAATCCTCAGCTGACACATAATTTGAATGGTGCAGAAAAAAAAAAAGAAACCGTAATTTTATTATTAGATTCTCCAAATGATT
TTCATCAATTTAAAATCATTCAATATCTGACAGTTACTCTTCAGTTTTAGGCTTACCTTGGTCATGCTTCAGTTGTACTTCCAGTGCGTC
TCTTTTGTTCCTGGCTTTGACATGAAAAGATAGGTTTGAGTTCAAATTTTGCATTGTGTGAGCTTCTACAGATTTTAGACAAGGACCGTT
TTTACTAAGTAAAAGGGTGGAGAGGTTCCTGGGGTGGATTCCTAAGCAGTGCTTGTAAACCATCGCGTGCAATGAGCCAGATGGAGTACC
ATGAGGGTTGCTATTTGTTGTTTTTAACAACTAATCAAGAGTGAGTGAACAACTATTTATAAACTAGATCTCCTATTTTTCAGAATGCTC
TTCTACGTATAAATATGAAATGATAAAGATGTCAAATATCTCAGAGGCTATAGCTGGGAACCCGACTGTGAAAGTATGTGATATCTGAAC
ACATACTAGAAAGCTCTGCATGTGTGTTGTCCTTCAGCATAATTCGGAAGGGAAAACAGTCGATCAAGGGATGTATTGGAACATGTCGGA
GTAGAAATTGTTCCTGATGTGCCAGAACTTCGACCCTTTCTCTGAGAGAGATGATCGTGCCTATAAATAGTAGGACCAATGTTGTGATTA
ACATCATCAGGCTTGGAATGAATTCTCTCTAAAAATAAAATGATGTATGATTTGTTGTTGGCATCCCCTTTATTAATTCATTAAATTTCT
GGATTTGGGTTGTGACCCAGGGTGCATTAACTTAAAAGATTCACTAAAGCAGCACATAGCACTGGGAACTCTGGCTCCGAAAAACTTTGT
TATATATATCAAGGATGTTCTGGCTTTACATTTTATTTATTAGCTGTAAATACATGTGTGGATGTGTAAATGGAGCTTGTACATATTGGA
AAGGTCATTGTGGCTATCTGCATTTATAAATGTGTGGTGCTAACTGTATGTGTCTTTATCAGTGATGGTCTCACAGAGCCAACTCACTCT
TATGAAATGGGCTTTAACAAAACAAGAAAGAAACGTACTTAACTGTGTGAAGAAATGGAATCAGCTTTTAATAAAATTGACAACATTTTA

>In-frame_ENST00000521209_ENST00000311322_TCGA-VQ-A91N-01A_MSRA_chr8_10102733_+_LPL_chr8_19805691_length(amino acids)=490AA_start in transcript=186_stop in transcript=1658
MAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSERRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKT
FMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAA
GIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAER
GLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQV
KIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKA

--------------------------------------------------------------
>In-frame_ENST00000528246_ENST00000311322_TCGA-VQ-A91N-01A_MSRA_chr8_10102733_+_LPL_chr8_19805691_length(transcript)=4044nt_BP=756nt
GAGTGAGAGAGAGAAAGAGGGAGAGAGAGAGGCAGAGGGAGAGCTGAGGAAAGAAAAAAAGGCAAGACTTGGCACAGCTCAGTCAAATCA
GCTTCTTTTGTCTGCTTTCTCGGCTTGAGCTTCAGGAAAGAAAACCGTCCTGGGGTACAGAAAAACTCAGAACTTTTTGGTTTTCAAACT
TAGAAGGCTTTTTAAGTCTCTTGGGCTATTTGAAAGTGTTGGTACATACAATGACGTTTAGTCACCAGTATTAAGGGAAATAAAAGCCTT
TTTCAAAACGAAGCTTCCATAGTGTCCATGCATTTGGGAAATACTATATTTGATTTTTTGCATGTATGATTATACCATGAGAGACAGGAT
TAATATAGAAGATGGCAAGGCAAATTTCTAATTAGAGGGAATATTAATTTTCTACAAAATAAAGTTTGTTCATCAATACAAACCTGCTTT
CAAATCAAATCAGAAAGACATCCTTCGGAATGTGTTCAGAACCAATTAGTGACAACACTGAAGACCAGAAAGGCAAGCTGAAGACACCAG
ACTTCGCTTGAAGGGCAAACAAGAAATCCAAACATCATGTCAATGGCAACAGAACAGTCGAACCTTTCCCAGAGGGAACACAGATGGCTG
TATTTGGAATGGGATGTTTCTGGGGAGCTGAAAGGAAATTCTGGGTCTTGAAAGGAGTGTATTCAACTCAAGTTGGTTTTGCAGGAGGCT
ATACTTCAAATCCTACTTATAAAGAAGTCTGCTCAGAAAGAAGAGATTTTATCGACATCGAAAGTAAATTTGCCCTAAGGACCCCTGAAG
ACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGTGGCTACCTGTCATTTCAATCACAGCAGCAAAACCTTCATGG
TGATCCATGGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTACAAGAGAGAACCAGACTCCAATG
TCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTCCGCGGGCTACACCAAACTGGTGGGACAGGATGTGGCCCGGT
TTATCAACTGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTTGGAGCCCATGCTGCTGGCATTG
CAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCCAGCTGGACCTAACTTTGAGTATGCAGAAGCCCCGAGTCGTC
TTTCTCCTGATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGCATTGGAATCCAGAAACCAGTTG
GGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAGCCAGGATGTAACATTGGAGAAGCTATCCGCGTGATTGCAGAGAGAGGACTTG
GAGATGTGGACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTGAATGAAGAAAATCCAAGTAAGG
CCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGGCTCTGCTTGAGTTGTAGAAAGAACCGCTGCAACAATCTGGGCTATGAGATCA
ATAAAGTCAGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTCTTCCATTACCAAGTAAAGATTC
ATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAGGCCTTTGAGATTTCTCTGTATGGCACCGTGGCCGAGAGTGAGAACATCCCAT
TCACTCTGCCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTACACAGAGGTAGATATTGGAGAACTACTCATGTTGAAGCTCA
AATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGGTGGAGCAGTCCCGGCTTCGCCATTCAGAAGATCAGAGTAAAAGCAGGAGAGA
CTCAGAAAAAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCGGTATTTGTGAAATGCCATGACA
AGTCTCTGAATAAGAAGTCAGGCTGAAACTGGGCGAATCTACAGAACAAAGAACGGCATGTGAATTCTGTGAAGAATGAAGTGGAGGAAG
TAACTTTTACAAAACATACCCAGTGTTTGGGGTGTTTCAAAAGTGGATTTTCCTGAATATTAATCCCAGCCCTACCCTTGTTAGTTATTT
TAGGAGACAGTCTCAAGCACTAAAAAGTGGCTAATTCAATTTATGGGGTATAGTGGCCAAATAGCACATCCTCCAACGTTAAAAGACAGT
GGATCATGAAAAGTGCTGTTTTGTCCTTTGAGAAAGAAATAATTGTTTGAGCGCAGAGTAAAATAAGGCTCCTTCATGTGGCGTATTGGG
CCATAGCCTATAATTGGTTAGAACCTCCTATTTTAATTGGAATTCTGGATCTTTCGGACTGAGGCCTTCTCAAACTTTACTCTAAGTCTC
CAAGAATACAGAAAATGCTTTTCCGCGGCACGAATCAGACTCATCTACACAGCAGTATGAATGATGTTTTAGAATGATTCCCTCTTGCTA
TTGGAATGTGGTCCAGACGTCAACCAGGAACATGTAACTTGGAGAGGGACGAAGAAAGGGTCTGATAAACACAGAGGTTTTAAACAGTCC
CTACCATTGGCCTGCATCATGACAAAGTTACAAATTCAAGGAGATATAAAATCTAGATCAATTAATTCTTAATAGGCTTTATCGTTTATT
GCTTAATCCCTCTCTCCCCCTTCTTTTTTGTCTCAAGATTATATTATAATAATGTTCTCTGGGTAGGTGTTGAAAATGAGCCTGTAATCC
TCAGCTGACACATAATTTGAATGGTGCAGAAAAAAAAAAAGAAACCGTAATTTTATTATTAGATTCTCCAAATGATTTTCATCAATTTAA
AATCATTCAATATCTGACAGTTACTCTTCAGTTTTAGGCTTACCTTGGTCATGCTTCAGTTGTACTTCCAGTGCGTCTCTTTTGTTCCTG
GCTTTGACATGAAAAGATAGGTTTGAGTTCAAATTTTGCATTGTGTGAGCTTCTACAGATTTTAGACAAGGACCGTTTTTACTAAGTAAA
AGGGTGGAGAGGTTCCTGGGGTGGATTCCTAAGCAGTGCTTGTAAACCATCGCGTGCAATGAGCCAGATGGAGTACCATGAGGGTTGCTA
TTTGTTGTTTTTAACAACTAATCAAGAGTGAGTGAACAACTATTTATAAACTAGATCTCCTATTTTTCAGAATGCTCTTCTACGTATAAA
TATGAAATGATAAAGATGTCAAATATCTCAGAGGCTATAGCTGGGAACCCGACTGTGAAAGTATGTGATATCTGAACACATACTAGAAAG
CTCTGCATGTGTGTTGTCCTTCAGCATAATTCGGAAGGGAAAACAGTCGATCAAGGGATGTATTGGAACATGTCGGAGTAGAAATTGTTC
CTGATGTGCCAGAACTTCGACCCTTTCTCTGAGAGAGATGATCGTGCCTATAAATAGTAGGACCAATGTTGTGATTAACATCATCAGGCT
TGGAATGAATTCTCTCTAAAAATAAAATGATGTATGATTTGTTGTTGGCATCCCCTTTATTAATTCATTAAATTTCTGGATTTGGGTTGT
GACCCAGGGTGCATTAACTTAAAAGATTCACTAAAGCAGCACATAGCACTGGGAACTCTGGCTCCGAAAAACTTTGTTATATATATCAAG
GATGTTCTGGCTTTACATTTTATTTATTAGCTGTAAATACATGTGTGGATGTGTAAATGGAGCTTGTACATATTGGAAAGGTCATTGTGG
CTATCTGCATTTATAAATGTGTGGTGCTAACTGTATGTGTCTTTATCAGTGATGGTCTCACAGAGCCAACTCACTCTTATGAAATGGGCT

>In-frame_ENST00000528246_ENST00000311322_TCGA-VQ-A91N-01A_MSRA_chr8_10102733_+_LPL_chr8_19805691_length(amino acids)=490AA_start in transcript=623_stop in transcript=2095
MAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSERRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKT
FMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAA
GIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAER
GLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQV
KIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKA

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>In-frame_ENST00000382490_ENST00000311322_TCGA-VQ-A91N-01A_MSRA_chr8_10102733_+_LPL_chr8_19805691_length(transcript)=3794nt_BP=506nt
AAACTTAGAAGGCTTTTTAAGTCTCTTGGGCTATTTGAAAGTGTTGGTACATACAATGACGTTTAGTCACCAGTATTAAGGGAAATAAAA
GCCTTTTTCAAAACGAAGCTTCCATAGTGTCCATGCATTTGGGAAATACTATATTTGATTTTTTGCATGTATGATTATACCATGAGAGAC
AGGATTAATATAGAAGATGGCAAGGCAAATTTCTAATTAGAGGGAATATTAATTTTCTACAAAATAAAGTTTGTTCATCAATACAAACCT
GCTTTCAAATCAAATCAGAAAGACATCCTTCGGAATGTGTTCAGAACCCAAACATCATGTCAATGGCAACAGAACAGTCGAACCTTTCCC
AGAGGGAACACAGATGGCTGTATTTGGAATGGGATGTTTCTGGGGAGCTGAAAGGAAATTCTGGGTCTTGAAAGGAGTGTATTCAACTCA
AGTTGGTTTTGCAGGAGGCTATACTTCAAATCCTACTTATAAAGAAGTCTGCTCAGAAAGAAGAGATTTTATCGACATCGAAAGTAAATT
TGCCCTAAGGACCCCTGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGTGGCTACCTGTCATTTCAATCA
CAGCAGCAAAACCTTCATGGTGATCCATGGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTACAA
GAGAGAACCAGACTCCAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTCCGCGGGCTACACCAAACTGGT
GGGACAGGATGTGGCCCGGTTTATCAACTGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTTGG
AGCCCATGCTGCTGGCATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCCAGCTGGACCTAACTTTGAGTA
TGCAGAAGCCCCGAGTCGTCTTTCTCCTGATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGCAT
TGGAATCCAGAAACCAGTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAGCCAGGATGTAACATTGGAGAAGCTATCCGCGT
GATTGCAGAGAGAGGACTTGGAGATGTGGACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTGAA
TGAAGAAAATCCAAGTAAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGGCTCTGCTTGAGTTGTAGAAAGAACCGCTGCAA
CAATCTGGGCTATGAGATCAATAAAGTCAGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTCTT
CCATTACCAAGTAAAGATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAGGCCTTTGAGATTTCTCTGTATGGCACCGTGGC
CGAGAGTGAGAACATCCCATTCACTCTGCCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTACACAGAGGTAGATATTGGAGA
ACTACTCATGTTGAAGCTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGGTGGAGCAGTCCCGGCTTCGCCATTCAGAAGAT
CAGAGTAAAAGCAGGAGAGACTCAGAAAAAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCGGT
ATTTGTGAAATGCCATGACAAGTCTCTGAATAAGAAGTCAGGCTGAAACTGGGCGAATCTACAGAACAAAGAACGGCATGTGAATTCTGT
GAAGAATGAAGTGGAGGAAGTAACTTTTACAAAACATACCCAGTGTTTGGGGTGTTTCAAAAGTGGATTTTCCTGAATATTAATCCCAGC
CCTACCCTTGTTAGTTATTTTAGGAGACAGTCTCAAGCACTAAAAAGTGGCTAATTCAATTTATGGGGTATAGTGGCCAAATAGCACATC
CTCCAACGTTAAAAGACAGTGGATCATGAAAAGTGCTGTTTTGTCCTTTGAGAAAGAAATAATTGTTTGAGCGCAGAGTAAAATAAGGCT
CCTTCATGTGGCGTATTGGGCCATAGCCTATAATTGGTTAGAACCTCCTATTTTAATTGGAATTCTGGATCTTTCGGACTGAGGCCTTCT
CAAACTTTACTCTAAGTCTCCAAGAATACAGAAAATGCTTTTCCGCGGCACGAATCAGACTCATCTACACAGCAGTATGAATGATGTTTT
AGAATGATTCCCTCTTGCTATTGGAATGTGGTCCAGACGTCAACCAGGAACATGTAACTTGGAGAGGGACGAAGAAAGGGTCTGATAAAC
ACAGAGGTTTTAAACAGTCCCTACCATTGGCCTGCATCATGACAAAGTTACAAATTCAAGGAGATATAAAATCTAGATCAATTAATTCTT
AATAGGCTTTATCGTTTATTGCTTAATCCCTCTCTCCCCCTTCTTTTTTGTCTCAAGATTATATTATAATAATGTTCTCTGGGTAGGTGT
TGAAAATGAGCCTGTAATCCTCAGCTGACACATAATTTGAATGGTGCAGAAAAAAAAAAAGAAACCGTAATTTTATTATTAGATTCTCCA
AATGATTTTCATCAATTTAAAATCATTCAATATCTGACAGTTACTCTTCAGTTTTAGGCTTACCTTGGTCATGCTTCAGTTGTACTTCCA
GTGCGTCTCTTTTGTTCCTGGCTTTGACATGAAAAGATAGGTTTGAGTTCAAATTTTGCATTGTGTGAGCTTCTACAGATTTTAGACAAG
GACCGTTTTTACTAAGTAAAAGGGTGGAGAGGTTCCTGGGGTGGATTCCTAAGCAGTGCTTGTAAACCATCGCGTGCAATGAGCCAGATG
GAGTACCATGAGGGTTGCTATTTGTTGTTTTTAACAACTAATCAAGAGTGAGTGAACAACTATTTATAAACTAGATCTCCTATTTTTCAG
AATGCTCTTCTACGTATAAATATGAAATGATAAAGATGTCAAATATCTCAGAGGCTATAGCTGGGAACCCGACTGTGAAAGTATGTGATA
TCTGAACACATACTAGAAAGCTCTGCATGTGTGTTGTCCTTCAGCATAATTCGGAAGGGAAAACAGTCGATCAAGGGATGTATTGGAACA
TGTCGGAGTAGAAATTGTTCCTGATGTGCCAGAACTTCGACCCTTTCTCTGAGAGAGATGATCGTGCCTATAAATAGTAGGACCAATGTT
GTGATTAACATCATCAGGCTTGGAATGAATTCTCTCTAAAAATAAAATGATGTATGATTTGTTGTTGGCATCCCCTTTATTAATTCATTA
AATTTCTGGATTTGGGTTGTGACCCAGGGTGCATTAACTTAAAAGATTCACTAAAGCAGCACATAGCACTGGGAACTCTGGCTCCGAAAA
ACTTTGTTATATATATCAAGGATGTTCTGGCTTTACATTTTATTTATTAGCTGTAAATACATGTGTGGATGTGTAAATGGAGCTTGTACA
TATTGGAAAGGTCATTGTGGCTATCTGCATTTATAAATGTGTGGTGCTAACTGTATGTGTCTTTATCAGTGATGGTCTCACAGAGCCAAC
TCACTCTTATGAAATGGGCTTTAACAAAACAAGAAAGAAACGTACTTAACTGTGTGAAGAAATGGAATCAGCTTTTAATAAAATTGACAA

>In-frame_ENST00000382490_ENST00000311322_TCGA-VQ-A91N-01A_MSRA_chr8_10102733_+_LPL_chr8_19805691_length(amino acids)=531AA_start in transcript=250_stop in transcript=1845
MFINTNLLSNQIRKTSFGMCSEPKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSERRDF
IDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVS
AGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTR
GSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLS
CRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIY

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Fusion Gene PPI Analysis for MSRA-LPL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneLPLchr8:10102733chr8:19805690ENST00000311322010443_46729.333333333333332476.0GPIHBP1
TgeneLPLchr8:10102733chr8:19805691ENST00000311322010443_46729.333333333333332476.0GPIHBP1
TgeneLPLchr8:10102733chr8:19805690ENST0000031132201032_5329.333333333333332476.0GPIHBP1
TgeneLPLchr8:10102733chr8:19805691ENST0000031132201032_5329.333333333333332476.0GPIHBP1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MSRA-LPL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLPLP06858DB13751Glycyrrhizic acidInducerSmall moleculeApproved|Experimental
TgeneLPLP06858DB13751Glycyrrhizic acidInducerSmall moleculeApproved|Experimental
TgeneLPLP06858DB06439TyloxapolInhibitorSmall moleculeApproved|Investigational
TgeneLPLP06858DB06439TyloxapolInhibitorSmall moleculeApproved|Investigational
TgeneLPLP06858DB09568Omega-3-carboxylic acidsStimulatorSmall moleculeApproved|Investigational
TgeneLPLP06858DB09568Omega-3-carboxylic acidsStimulatorSmall moleculeApproved|Investigational

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Related Diseases for MSRA-LPL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMSRAC0036341Schizophrenia2PSYGENET
HgeneMSRAC0013146Drug abuse1CTD_human
HgeneMSRAC0013170Drug habituation1CTD_human
HgeneMSRAC0013222Drug Use Disorders1CTD_human
HgeneMSRAC0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneMSRAC0038580Substance Dependence1CTD_human
HgeneMSRAC0038586Substance Use Disorders1CTD_human
HgeneMSRAC0236969Substance-Related Disorders1CTD_human
HgeneMSRAC0740858Substance abuse problem1CTD_human
HgeneMSRAC1510472Drug Dependence1CTD_human
HgeneMSRAC4316881Prescription Drug Abuse1CTD_human
TgeneLPLC0023817Hyperlipoproteinemia Type I58CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneLPLC0020474Hyperlipidemia, Familial Combined7CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneLPLC0020557Hypertriglyceridemia2CTD_human
TgeneLPLC0007097Carcinoma1CTD_human
TgeneLPLC0007102Malignant tumor of colon1CTD_human
TgeneLPLC0007222Cardiovascular Diseases1CTD_human
TgeneLPLC0007570Celiac Disease1CTD_human
TgeneLPLC0009375Colonic Neoplasms1CTD_human
TgeneLPLC0019196Hepatitis C1CTD_human
TgeneLPLC0020443Hypercholesterolemia1CTD_human;GENOMICS_ENGLAND
TgeneLPLC0020445Hypercholesterolemia, Familial1CTD_human
TgeneLPLC0020473Hyperlipidemia1CTD_human
TgeneLPLC0020538Hypertensive disease1CTD_human
TgeneLPLC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneLPLC0024667Animal Mammary Neoplasms1CTD_human
TgeneLPLC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneLPLC0027540Necrosis1CTD_human
TgeneLPLC0028754Obesity1CTD_human
TgeneLPLC0030305Pancreatitis1CTD_human
TgeneLPLC0033141Cardiomyopathies, Primary1CTD_human
TgeneLPLC0033578Prostatic Neoplasms1CTD_human
TgeneLPLC0036341Schizophrenia1PSYGENET
TgeneLPLC0036529Myocardial Diseases, Secondary1CTD_human
TgeneLPLC0205696Anaplastic carcinoma1CTD_human
TgeneLPLC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneLPLC0205698Undifferentiated carcinoma1CTD_human
TgeneLPLC0205699Carcinomatosis1CTD_human
TgeneLPLC0242339Dyslipidemias1CTD_human
TgeneLPLC0376358Malignant neoplasm of prostate1CTD_human
TgeneLPLC0598784Dyslipoproteinemias1CTD_human
TgeneLPLC0745103Hyperlipoproteinemia Type IIa1CTD_human
TgeneLPLC0878544Cardiomyopathies1CTD_human
TgeneLPLC1257925Mammary Carcinoma, Animal1CTD_human
TgeneLPLC1704417Hyperlipoproteinemia Type IIb1CTD_human
TgeneLPLC1706412Lipidemias1CTD_human