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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MTCH2-FHIT (FusionGDB2 ID:55234)

Fusion Gene Summary for MTCH2-FHIT

check button Fusion gene summary
Fusion gene informationFusion gene name: MTCH2-FHIT
Fusion gene ID: 55234
HgeneTgene
Gene symbol

MTCH2

FHIT

Gene ID

23788

2272

Gene namemitochondrial carrier 2fragile histidine triad diadenosine triphosphatase
SynonymsHSPC032|MIMP|SLC25A50AP3Aase|FRA3B
Cytomap

11p11.2

3p14.2

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial carrier homolog 22310034D24Rikmet-induced mitochondrial proteinsolute carrier family 25, member 50bis(5'-adenosyl)-triphosphataseAP3A hydrolasediadenosine 5',5'''-P1,P3-triphosphate hydrolasedinucleosidetriphosphatase
Modification date2020031320200313
UniProtAcc

Q9Y6C9

P49789

Ensembl transtripts involved in fusion geneENST00000302503, ENST00000542981, 
ENST00000534074, 		ENST00000476844, 
ENST00000492590, ENST00000466788, 
ENST00000468189, ENST00000341848, 
Fusion gene scores* DoF score8 X 7 X 4=22427 X 20 X 11=5940
# samples 932
** MAII scorelog2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/5940*10)=-4.21431912080077
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MTCH2 [Title/Abstract] AND FHIT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMTCH2(47660251)-FHIT(59738047), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFHIT

GO:0006163

purine nucleotide metabolic process

9323207


check buttonFusion gene breakpoints across MTCH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FHIT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-2077-01AMTCH2chr11

47660251

-FHITchr3

59738047

-
ChimerDB4OVTCGA-23-2077-01AMTCH2chr11

47660251

-FHITchr3

59738047

-
ChimerDB4OVTCGA-23-2077-01AMTCH2chr11

47660251

-FHITchr3

59738047

-


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Fusion Gene ORF analysis for MTCH2-FHIT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000302503ENST00000476844MTCH2chr11

47660251

-FHITchr3

59738047

-
In-frameENST00000302503ENST00000492590MTCH2chr11

47660251

-FHITchr3

59738047

-
5CDS-5UTRENST00000302503ENST00000466788MTCH2chr11

47660251

-FHITchr3

59738047

-
5CDS-5UTRENST00000302503ENST00000468189MTCH2chr11

47660251

-FHITchr3

59738047

-
5CDS-5UTRENST00000302503ENST00000341848MTCH2chr11

47660251

-FHITchr3

59738047

-
5UTR-3CDSENST00000542981ENST00000476844MTCH2chr11

47660251

-FHITchr3

59738047

-
5UTR-3CDSENST00000542981ENST00000492590MTCH2chr11

47660251

-FHITchr3

59738047

-
5UTR-5UTRENST00000542981ENST00000466788MTCH2chr11

47660251

-FHITchr3

59738047

-
5UTR-5UTRENST00000542981ENST00000468189MTCH2chr11

47660251

-FHITchr3

59738047

-
5UTR-5UTRENST00000542981ENST00000341848MTCH2chr11

47660251

-FHITchr3

59738047

-
intron-3CDSENST00000534074ENST00000476844MTCH2chr11

47660251

-FHITchr3

59738047

-
intron-3CDSENST00000534074ENST00000492590MTCH2chr11

47660251

-FHITchr3

59738047

-
intron-5UTRENST00000534074ENST00000466788MTCH2chr11

47660251

-FHITchr3

59738047

-
intron-5UTRENST00000534074ENST00000468189MTCH2chr11

47660251

-FHITchr3

59738047

-
intron-5UTRENST00000534074ENST00000341848MTCH2chr11

47660251

-FHITchr3

59738047

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000302503MTCH2chr1147660251-ENST00000476844FHITchr359738047-79743729532167
ENST00000302503MTCH2chr1147660251-ENST00000492590FHITchr359738047-80843729532167

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302503ENST00000476844MTCH2chr1147660251-FHITchr359738047-0.0292829870.97071695
ENST00000302503ENST00000492590MTCH2chr1147660251-FHITchr359738047-0.0373738260.9626262

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Fusion Genomic Features for MTCH2-FHIT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MTCH2-FHIT


check button Go to

FGviewer for the breakpoints of chr11:47660251-chr3:59738047

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTCH2

Q9Y6C9

FHIT

P49789

FUNCTION: The substrate transported is not yet known. Induces mitochondrial depolarization.FUNCTION: Possesses dinucleoside triphosphate hydrolase activity (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9576908, PubMed:9543008). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9576908, PubMed:9543008). Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (PubMed:8794732). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (PubMed:18694747). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:18694747). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (PubMed:26181368). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (PubMed:26181368). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (PubMed:18077326). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (PubMed:16407838). Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (PubMed:15313915). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake (PubMed:12574506, PubMed:19622739). Functions as tumor suppressor (By similarity). {ECO:0000250|UniProtKB:O89106, ECO:0000269|PubMed:12574506, ECO:0000269|PubMed:15313915, ECO:0000269|PubMed:16407838, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18694747, ECO:0000269|PubMed:19622739, ECO:0000269|PubMed:26181368, ECO:0000269|PubMed:8794732, ECO:0000269|PubMed:9323207, ECO:0000269|PubMed:9543008}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTCH2chr11:47660251chr3:59738047ENST00000302503-3138_2893.0304.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTCH2chr11:47660251chr3:59738047ENST00000302503-313118_20693.0304.0RepeatNote=Solcar 2
HgeneMTCH2chr11:47660251chr3:59738047ENST00000302503-3132_9893.0304.0RepeatNote=Solcar 1
HgeneMTCH2chr11:47660251chr3:59738047ENST00000302503-313175_19593.0304.0TransmembraneHelical
HgeneMTCH2chr11:47660251chr3:59738047ENST00000302503-313224_24493.0304.0TransmembraneHelical
TgeneFHITchr11:47660251chr3:59738047ENST00000341848352_109116.0148.0DomainHIT
TgeneFHITchr11:47660251chr3:59738047ENST00000468189792_109116.0148.0DomainHIT
TgeneFHITchr11:47660251chr3:59738047ENST000004768447102_109116.0214.0DomainHIT
TgeneFHITchr11:47660251chr3:59738047ENST000004925907102_109116.0205.33333333333334DomainHIT
TgeneFHITchr11:47660251chr3:59738047ENST000003418483594_98116.0148.0MotifHistidine triad motif
TgeneFHITchr11:47660251chr3:59738047ENST000004681897994_98116.0148.0MotifHistidine triad motif
TgeneFHITchr11:47660251chr3:59738047ENST0000047684471094_98116.0214.0MotifHistidine triad motif
TgeneFHITchr11:47660251chr3:59738047ENST0000049259071094_98116.0205.33333333333334MotifHistidine triad motif
TgeneFHITchr11:47660251chr3:59738047ENST000003418483589_92116.0148.0Nucleotide bindingSubstrate
TgeneFHITchr11:47660251chr3:59738047ENST000004681897989_92116.0148.0Nucleotide bindingSubstrate
TgeneFHITchr11:47660251chr3:59738047ENST0000047684471089_92116.0214.0Nucleotide bindingSubstrate
TgeneFHITchr11:47660251chr3:59738047ENST0000049259071089_92116.0205.33333333333334Nucleotide bindingSubstrate


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Fusion Gene Sequence for MTCH2-FHIT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000302503_ENST00000476844_TCGA-23-2077-01A_MTCH2_chr11_47660251_-_FHIT_chr3_59738047_length(transcript)=797nt_BP=437nt
GGGGCGGGGACTGGGCGGAGAGGCGCGTGCTGCTGCGTGCGTGCGCGCGCGCCGCGGGCGGGCCAGTGAAACCGGCGGCCCTGGCACGTG
ACCTAGGACCGGCTCACCGGGTCGCTTGGTGGCTCCGTCTGTCTGTCCGTCCGCCCGCGGGTGCCATCATGGCGGACGCGGCCAGTCAGG
TGCTCCTGGGCTCCGGTCTCACCATCCTGTCCCAGCCGCTCATGTACGTGAAAGTGCTCATCCAGGTGGGATATGAGCCTCTTCCTCCAA
CAATAGGACGAAATATTTTTGGGCGGCAAGTGTGTCAGCTTCCTGGTCTCTTTAGTTATGCTCAGCACATTGCCAGTATCGATGGGAGGC
GCGGGTTGTTCACAGGCTTAACTCCAAGACTGTGTTCGGGAGTCCTTGGAACTGTGGTCCATGGTAAAGTTTTACAGCTCCAGAAACATG
ACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGAT
CCTGAATTCCAGCAAAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGCATGAAAATGCA
GTTTCTTCATCTCACCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAGACCTAAACGGC

>In-frame_ENST00000302503_ENST00000476844_TCGA-23-2077-01A_MTCH2_chr11_47660251_-_FHIT_chr3_59738047_length(amino acids)=167AA_start in transcript=29_stop in transcript=532
MLRACARAAGGPVKPAALARDLGPAHRVAWWLRLSVRPPAGAIMADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIFGRQ

--------------------------------------------------------------
>In-frame_ENST00000302503_ENST00000492590_TCGA-23-2077-01A_MTCH2_chr11_47660251_-_FHIT_chr3_59738047_length(transcript)=808nt_BP=437nt
GGGGCGGGGACTGGGCGGAGAGGCGCGTGCTGCTGCGTGCGTGCGCGCGCGCCGCGGGCGGGCCAGTGAAACCGGCGGCCCTGGCACGTG
ACCTAGGACCGGCTCACCGGGTCGCTTGGTGGCTCCGTCTGTCTGTCCGTCCGCCCGCGGGTGCCATCATGGCGGACGCGGCCAGTCAGG
TGCTCCTGGGCTCCGGTCTCACCATCCTGTCCCAGCCGCTCATGTACGTGAAAGTGCTCATCCAGGTGGGATATGAGCCTCTTCCTCCAA
CAATAGGACGAAATATTTTTGGGCGGCAAGTGTGTCAGCTTCCTGGTCTCTTTAGTTATGCTCAGCACATTGCCAGTATCGATGGGAGGC
GCGGGTTGTTCACAGGCTTAACTCCAAGACTGTGTTCGGGAGTCCTTGGAACTGTGGTCCATGGTAAAGTTTTACAGCTCCAGAAACATG
ACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGAT
GTTTTTCAGATCCTGAATTCCAGCAAAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGC
ATGAAAATGCAGTTTCTTCATCTCACCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAG

>In-frame_ENST00000302503_ENST00000492590_TCGA-23-2077-01A_MTCH2_chr11_47660251_-_FHIT_chr3_59738047_length(amino acids)=167AA_start in transcript=29_stop in transcript=532
MLRACARAAGGPVKPAALARDLGPAHRVAWWLRLSVRPPAGAIMADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIFGRQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MTCH2-FHIT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MTCH2-FHIT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MTCH2-FHIT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTCH2C0028754Obesity1CTD_human
TgeneFHITC0024121Lung Neoplasms2CTD_human
TgeneFHITC0025500Mesothelioma2CTD_human
TgeneFHITC0242379Malignant neoplasm of lung2CTD_human
TgeneFHITC0007097Carcinoma1CTD_human
TgeneFHITC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneFHITC0013146Drug abuse1CTD_human
TgeneFHITC0013170Drug habituation1CTD_human
TgeneFHITC0013222Drug Use Disorders1CTD_human
TgeneFHITC0023903Liver neoplasms1CTD_human
TgeneFHITC0024623Malignant neoplasm of stomach1CTD_human
TgeneFHITC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneFHITC0033578Prostatic Neoplasms1CTD_human
TgeneFHITC0038356Stomach Neoplasms1CTD_human
TgeneFHITC0038580Substance Dependence1CTD_human
TgeneFHITC0038586Substance Use Disorders1CTD_human
TgeneFHITC0042076Urologic Neoplasms1CTD_human
TgeneFHITC0205696Anaplastic carcinoma1CTD_human
TgeneFHITC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneFHITC0205698Undifferentiated carcinoma1CTD_human
TgeneFHITC0205699Carcinomatosis1CTD_human
TgeneFHITC0236733Amphetamine-Related Disorders1CTD_human
TgeneFHITC0236804Amphetamine Addiction1CTD_human
TgeneFHITC0236807Amphetamine Abuse1CTD_human
TgeneFHITC0236969Substance-Related Disorders1CTD_human
TgeneFHITC0345904Malignant neoplasm of liver1CTD_human
TgeneFHITC0376358Malignant neoplasm of prostate1CTD_human
TgeneFHITC0740858Substance abuse problem1CTD_human
TgeneFHITC0751571Cancer of Urinary Tract1CTD_human
TgeneFHITC1510472Drug Dependence1CTD_human
TgeneFHITC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneFHITC4316881Prescription Drug Abuse1CTD_human