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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MTUS2-SIRT7 (FusionGDB2 ID:55625) |
Fusion Gene Summary for MTUS2-SIRT7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTUS2-SIRT7 | Fusion gene ID: 55625 | Hgene | Tgene | Gene symbol | MTUS2 | SIRT7 | Gene ID | 23281 | 51547 |
| Gene name | microtubule associated scaffold protein 2 | sirtuin 7 | |
| Synonyms | CAZIP|ICIS|KIAA0774|TIP150 | SIR2L7 | |
| Cytomap | 13q12.3 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | microtubule-associated tumor suppressor candidate 2+TIP of 150 kDacardiac zipper proteinmicrotubule associated tumor suppressor candidate 2microtubule plus-end tracking protein TIP150tracking protein of 150 kDa | NAD-dependent protein deacetylase sirtuin-7NAD-dependent deacetylase sirtuin-7SIR2-like protein 7regulatory protein SIR2 homolog 7silent mating type information regulation 2, S.cerevisiae, homolog 7sir2-related protein type 7sirtuin type 7 | |
| Modification date | 20200327 | 20200320 | |
| UniProtAcc | Q5JR59 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000431530, ENST00000380808, ENST00000542829, ENST00000400542, | ENST00000328666, | |
| Fusion gene scores | * DoF score | 16 X 10 X 5=800 | 3 X 3 X 3=27 |
| # samples | 16 | 4 | |
| ** MAII score | log2(16/800*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MTUS2 [Title/Abstract] AND SIRT7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MTUS2(30054501)-SIRT7(79875843), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SIRT7 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 22722849 |
| Tgene | SIRT7 | GO:0006282 | regulation of DNA repair | 27436229|30944854 |
| Tgene | SIRT7 | GO:0006476 | protein deacetylation | 24207024|26867678|28426094|28790157|28886238|30540930|30944854|31075303 |
| Tgene | SIRT7 | GO:0006974 | cellular response to DNA damage stimulus | 27436229|30944854 |
| Tgene | SIRT7 | GO:0016570 | histone modification | 27436229 |
| Tgene | SIRT7 | GO:0031397 | negative regulation of protein ubiquitination | 28886238 |
| Tgene | SIRT7 | GO:0036049 | peptidyl-lysine desuccinylation | 27436229 |
| Tgene | SIRT7 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 28426094 |
| Tgene | SIRT7 | GO:0061698 | protein deglutarylation | 31542297 |
| Tgene | SIRT7 | GO:0070932 | histone H3 deacetylation | 22722849|26907567|28655758|30420520|30653310 |
| Tgene | SIRT7 | GO:1901836 | regulation of transcription of nucleolar large rRNA by RNA polymerase I | 24207024 |
| Tgene | SIRT7 | GO:1990258 | histone glutamine methylation | 30540930 |
| Tgene | SIRT7 | GO:2000234 | positive regulation of rRNA processing | 26867678 |
| Fusion gene breakpoints across MTUS2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across SIRT7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-DX-A8BK-01A | MTUS2 | chr13 | 30054501 | + | SIRT7 | chr17 | 79875843 | - |
| ChimerDB4 | SARC | TCGA-DX-A8BK-01A | MTUS2 | chr13 | 30054501 | - | SIRT7 | chr17 | 79875843 | - |
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Fusion Gene ORF analysis for MTUS2-SIRT7 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000431530 | ENST00000328666 | MTUS2 | chr13 | 30054501 | + | SIRT7 | chr17 | 79875843 | - |
| In-frame | ENST00000380808 | ENST00000328666 | MTUS2 | chr13 | 30054501 | + | SIRT7 | chr17 | 79875843 | - |
| In-frame | ENST00000542829 | ENST00000328666 | MTUS2 | chr13 | 30054501 | + | SIRT7 | chr17 | 79875843 | - |
| intron-3CDS | ENST00000400542 | ENST00000328666 | MTUS2 | chr13 | 30054501 | + | SIRT7 | chr17 | 79875843 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000431530 | MTUS2 | chr13 | 30054501 | + | ENST00000328666 | SIRT7 | chr17 | 79875843 | - | 5074 | 3487 | 58 | 4596 | 1512 |
| ENST00000380808 | MTUS2 | chr13 | 30054501 | + | ENST00000328666 | SIRT7 | chr17 | 79875843 | - | 2139 | 552 | 162 | 1661 | 499 |
| ENST00000542829 | MTUS2 | chr13 | 30054501 | + | ENST00000328666 | SIRT7 | chr17 | 79875843 | - | 1990 | 403 | 163 | 1512 | 449 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000431530 | ENST00000328666 | MTUS2 | chr13 | 30054501 | + | SIRT7 | chr17 | 79875843 | - | 0.004650629 | 0.99534935 |
| ENST00000380808 | ENST00000328666 | MTUS2 | chr13 | 30054501 | + | SIRT7 | chr17 | 79875843 | - | 0.037660737 | 0.9623392 |
| ENST00000542829 | ENST00000328666 | MTUS2 | chr13 | 30054501 | + | SIRT7 | chr17 | 79875843 | - | 0.08585269 | 0.9141473 |
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Fusion Genomic Features for MTUS2-SIRT7 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MTUS2-SIRT7 |
| Go to FGviewer for the breakpoints of chr13:30054501-chr17:79875843 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTUS2 | . |
| FUNCTION: Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. {ECO:0000269|PubMed:19543227}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SIRT7 | chr13:30054501 | chr17:79875843 | ENST00000328666 | 0 | 10 | 90_331 | 31.0 | 401.0 | Domain | Deacetylase sirtuin-type | |
| Tgene | SIRT7 | chr13:30054501 | chr17:79875843 | ENST00000328666 | 0 | 10 | 107_126 | 31.0 | 401.0 | Nucleotide binding | NAD | |
| Tgene | SIRT7 | chr13:30054501 | chr17:79875843 | ENST00000328666 | 0 | 10 | 167_170 | 31.0 | 401.0 | Nucleotide binding | NAD | |
| Tgene | SIRT7 | chr13:30054501 | chr17:79875843 | ENST00000328666 | 0 | 10 | 268_270 | 31.0 | 401.0 | Nucleotide binding | NAD | |
| Tgene | SIRT7 | chr13:30054501 | chr17:79875843 | ENST00000328666 | 0 | 10 | 297_299 | 31.0 | 401.0 | Nucleotide binding | NAD |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MTUS2 | chr13:30054501 | chr17:79875843 | ENST00000380808 | + | 3 | 9 | 991_1335 | 112.0 | 349.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MTUS2 | chr13:30054501 | chr17:79875843 | ENST00000542829 | + | 2 | 8 | 991_1335 | 22.0 | 259.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MTUS2 | chr13:30054501 | chr17:79875843 | ENST00000380808 | + | 3 | 9 | 801_1150 | 112.0 | 349.0 | Region | Note=Localization to the growing distal tip of microtubules |
| Hgene | MTUS2 | chr13:30054501 | chr17:79875843 | ENST00000542829 | + | 2 | 8 | 801_1150 | 22.0 | 259.0 | Region | Note=Localization to the growing distal tip of microtubules |
| Tgene | SIRT7 | chr13:30054501 | chr17:79875843 | ENST00000328666 | 0 | 10 | 8_74 | 31.0 | 401.0 | Compositional bias | Note=Arg-rich |
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Fusion Gene Sequence for MTUS2-SIRT7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000431530_ENST00000328666_TCGA-DX-A8BK-01A_MTUS2_chr13_30054501_+_SIRT7_chr17_79875843_length(transcript)=5074nt_BP=3487nt ATTTCCTCTTAATCTGATTGCAGCTTGAAGGCAGCCCATTTCCATTAAGTAGGACTGCATGGCAAGCAGCCCCACCAAAGGGTTGACAAT GAGCGTCCCAGTGGCTCCTAAGAAATCATGTTACACTCAGTTGCGGGACAACAGAAATGCAGCAAGAAATAATAATGAAAGCATCTTAAG TCTGGGAGATACGAATGCCAATCAAATCATGTTGGAGGTCAGCTCCTCTCATGACGAGTCCAAGACATGTGACCTGGGAGATGAAATTGG AAATACAAATTCAAGTGAGCCAGAAAACCGTACCCATTTCCATAAGGAATTTCACCAACTTCAGGGCTTTGGGAAAGGCTCTCAGGCTGG CTCTGCCAGCCTGAAAGATTTTAGACTTTCTTCAACCATTCAGAGGGAACTCAATGAAGAGCACACAGTGGAGAGAGGCACAGATAGCCT GCAGACCACGCGGAGTATTCAGGGACCAAGTCTGTCGAGTTGGAGGAATGTGATGAGTGAGGCCAGTCTAGACGTTTTGGCTAAAAGGGA TGCTGAAATTCCCCGGCATGTTCCCAAGGATAAACTGGCAAAGACCCTTGACAATGAGGAACTGAGGAGGCATTCTTTGGAAAGAGCAAG CAGCTCTGTAGCTGCAGTCGGGAGCCTGACTCCGCAGCATCCACAGCCTCTATCCCTCGACTCCCGGGAAGCACGGGGTCAGATACCTGG GGGTGGGGAGGGGCCACAGAAGACATTGCCAGACCACGCTGTCCCGGCAGCTTTCCCTGCAACTGACAGTACCTCAGAGGGAAAGAGTGT GCGTCATCCTAAACCATCTACCTCAGAAAGCAAGCAGAGCACTCCCTCAGAGACCCAAACAGTGGGGGCACATGTACTGCAGGTGTGCAG TGAGCACACATCACATTCCGCCCATCCAGAGCCTGCTCTGAATTTGACTTTGGCATCGAAGGAAATCCCAAGTAAACTGGAAGCACAATT AGGTCAGGGAAAGGGAGAGGCCAAGCTGGATCTGAAATATGTTCCTCCCAGGAGAGTTGAACAGGAGGGAAAGGCAGCCCAGGAAGGGTA TCTGGGATGCCACAAGGAAGAGAATCTGTCAGCCTTGGAGGGAAGGGATCCATGTGGGGAAGCACACCCGGAAGCCACCGATGCACTTGG CCATCTGCTGAACAGTGACCTCCACCACCTTGGGGTGGGAAGAGGCAACTGTGAAGAGAAGAGAGGAGTCAACCCAGGGGAGCAGGATTC TCTCCACACCACCCCCAAACAGGGCTCTGCTTCCTTAGGAGGGGCTGATAATCAGCCCACTGGCAAAATTTCACCATGTGCAGGTGAGAA GTTGGGTGAAAGGACATCCAGCAGCTTTTCACCAGGTGACAGTCATGTGGCTTTTATTCCTAATAATCTGACTGACAGCAAGCCCTTGGA TGTCATTGAGGAGGAAAGGCGGTTGGGCAGTGGGAATAAGGACAGTGTTATGGTTTTGGTGTTCAATCCTTCTGTTGGAGAGAACAAGAC GGAGGTGCCTGAGCCCCTGGACCCTCAAAGTGGCCGCTCAGAAGCACGGGAAAGCAAAGAGGTCACCACATCTGTTGCTGAAAACAGGAA CCTTCTAGAGAATGCAGATAAGATTGAAAGCACCTCAGCAAGAGCAGATTCAGTTCTCAATATTCCAGCACCCCTCCACCCAGAGACAAC TGTGAACATGACCTACCAGCCTACAACACCCAGTAGCAGTTTTCAGGATGTTAGCGTGTTCGGTATGGATGCGGGGTCCCCCTTGGTAGT TCCACCCCCTACTGATAGTGCACGCTTGTTGAACACGTCCCCCAAAGTGCCTGACAAGAACACTTGCCCCAGTGGGATCCCCAAGCCTGT CTTCACACATTCCAAGGACACACCTTCCTCGCAGGAGGGAATGGAGAACTATCAGGTTGAAAAAACAGAGGAGAGGACAGAAACTAAGCC CATCATTATGCCCAAGCCCAAGCATGTGAGGCCCAAGATCATCACCTACATCAGGAGGAATCCCCAGGCCCTGGGCCAGGTGGACGCCTC GCTGGTTCCAGTGGGGCTTCCATATGCCCCGCCCACATGTACCATGCCTCTTCCCCACGAAGAGAAGGCAGCAGGTGGTGACCTGAAGCC ATCTGCCAACCTCTATGAGAAATTCAAGCCAGACCTGCAGAAGCCAAGGGTCTTCAGTTCCGGATTGATGGTGTCTGGAATCAAGCCCCC GGGACATCCTTTCAGTCAAATGAGTGAAAAGTTTTTGCAGGAGGTTACAGACCACCCTGGAAAAGAAGAGTTTTGTTCTCCTCCCTATGC TCATTATGAAGTCCCTCCAACTTTCTATCGGTCAGCCATGCTCCTTAAGCCCCAGCTAGGATTGGGTGCAATGTCCCGTTTACCATCTGC AAAGAGCAGGATTCTGATTGCAAGTCAGAGGTCTTCAGCGAGCGCCATCCACCCACCAGGACCCATAACAACAGCCACCAGTCTCTACAG TTCCGATCCTTCAGCAGATTTAAAGAAAGCTTCCAGTTCAAATGCTGCAAAATCCAATCTCCCGAAATCTGGTCTCCGTCCTCCCGGATA CTCACGTCTCCCGGCAGCCAAACTGGCGGCATTTGGCTTTGTCCGGAGCTCCAGCGTCTCCTCAGTCTCCAGCACCCAGTCCGGGGACAG TGCACAGCCAGAGCAGGGCCGGCCAGCCACCCGTTCAACCTTTGGGAATGAAGAACAGCCAGTTCTGAAGGCATCTCTGCCTTCTAAGGA CACACCCAAGGGGGCCGGCCGGGTGGCCCCTCCAGCATCCTCCAGTGTGACAGCACCCCGCAGGAGTTTACTTCCAGCGCCAAAATCCAC TTCCACACCCGCTGGAACAAAGAAAGATGCTCAGAAAGATCAAGATACGAATAAACCTGCTGTTTCATCTCCTAAGAGAGTAGCAGCTTC AACCACCAAGCTTCATTCACCAGGATACCCAAAGCAGAGGACTGCGGCAGCTCGAAATGGGTTTCCGCCCAAGCCGGACCCGCAGGCCCG TGAGGCTGAGCGGCAGCTGGTGCTGCGGCTGAAGGAGCGGTGTGAGCAGCAGACCAGACAGCTGGGCGTTGCGCAAGGGGAGCTGAAGAG GGCCATCTGCGGCTTTGATGCCCTCGCCGTGGCCACGCAGCATTTCTTTAGAAAGAATGAAAGTGCCCTTGTGAAAGAAAAAGAGCTGTC AATCGAACTTGCAAACATCAGGGATGAAGTTGCCTTCCATACAGCAAAGTGCGAGAAACTACAAAAGGAGAAGGAGGAGCTGGAGAGGCG GTTCGAGGACGAGGTGAAGAGGCTGGGCTGGCAGCAGCAGGCCGAGCTCCAGGAGCTGGAGGAGCGGCTGCAGCTGCAATTCGAGGCGGA AATGGCGCGCCTGCAGGAGGAGCACGGTGACCAGCTGCTGAGCATCCGGTGTCAACACCAGGAGCAGGTGTCGCGCATCCTGAGGAAGGC GGCGGCGGAGCGCAGCGCCGAGGAGGGCCGGCTGCTGGCCGAGAGCGCGGACCTGGTAACGGAGCTGCAGGGCCGGAGCCGGCGGCGCGA GGGCCTGAAGCGGCGGCAGGAGGAGGTGTGCGACGACCCGGAGGAGCTGCGGGGGAAGGTCCGGGAGCTGGCCAGCGCCGTCCGGAACGC CAAATACTTGGTCGTCTACACAGGCGCGGGAATCAGCACGGCAGCGTCTATCCCAGACTACCGGGGCCCTAATGGAGTGTGGACACTGCT TCAGAAAGGGAGAAGCGTTAGTGCTGCCGACCTGAGCGAGGCCGAGCCAACCCTCACCCACATGAGCATCACCCGTCTGCATGAGCAGAA GCTGGTGCAGCATGTGGTGTCTCAGAACTGTGACGGGCTCCACCTGAGGAGTGGGCTGCCGCGCACGGCCATCTCCGAGCTCCACGGGAA CATGTACATTGAAGTCTGTACCTCCTGCGTTCCCAACAGGGAGTACGTGCGGGTGTTCGATGTGACGGAGCGCACTGCCCTCCACAGACA CCAGACAGGCCGGACCTGCCACAAGTGTGGGACCCAGCTGCGGGACACCATTGTGCACTTTGGGGAGAGGGGGACGTTGGGGCAGCCTTT GAACTGGGAAGCGGCGACCGAGGCTGCCAGCAGAGCAGACACCATCCTGTGTCTAGGGTCCAGCCTGAAGGTTCTAAAGAAGTACCCACG CCTCTGGTGCATGACCAAGCCCCCTAGCCGGCGGCCGAAGCTTTACATCGTGAACCTGCAGTGGACCCCGAAGGATGACTGGGCTGCCCT GAAGCTACATGGGAAGTGTGATGACGTCATGCGGCTCCTCATGGCCGAGCTGGGCTTGGAGATCCCCGCCTATAGCAGGTGGCAGGATCC CATTTTCTCACTGGCGACTCCCCTGCGTGCTGGTGAAGAAGGCAGCCACAGTCGGAAGTCGCTGTGCAGAAGCAGAGAGGAGGCCCCGCC TGGGGACCGGGGTGCACCGCTTAGCTCGGCCCCCATCCTAGGGGGCTGGTTTGGCAGGGGCTGCACAAAACGCACAAAAAGGAAGAAAGT GACGTAATCACGTGCTCGATGAAGAACAGTTGGCACTTTGCAGATGGCCAGTGTCACGGTGAAGGCTGGGTTGCCCCCACGGGTCTAGGG AGAACGAACTCTTTGGGGATGACATTTTCACCGTGACATTTTTAGCCATTTGTCCTTGAGGAAGCCCCTTGCACTGCTGCGGTTGTACCC TGATACGGCCTGGCCATCGAGGACACCTGCCCATCCGGCCTCTGTGTCAAGAGGTGGCAGCCGCACCTTTCTGTGAGAACGGAACTCGGG TTATTTCAGCCCCGGCCTGCAGAGTGGAAGCGCCCAGCGGCCTTTCCTCGCTCACCAGGCCAGTCTCAGGGCCTCACCGTATTTCTACTA CTACTTAATGAAAAAGTGTGAACTTTATAGAATCCTCTCTGTACTGGATGTGCGGCAGAGGGGTGGCTCCGAGCCTCGGCTCTATGCAGA >In-frame_ENST00000431530_ENST00000328666_TCGA-DX-A8BK-01A_MTUS2_chr13_30054501_+_SIRT7_chr17_79875843_length(amino acids)=1512AA_start in transcript=58_stop in transcript=4596 MASSPTKGLTMSVPVAPKKSCYTQLRDNRNAARNNNESILSLGDTNANQIMLEVSSSHDESKTCDLGDEIGNTNSSEPENRTHFHKEFHQ LQGFGKGSQAGSASLKDFRLSSTIQRELNEEHTVERGTDSLQTTRSIQGPSLSSWRNVMSEASLDVLAKRDAEIPRHVPKDKLAKTLDNE ELRRHSLERASSSVAAVGSLTPQHPQPLSLDSREARGQIPGGGEGPQKTLPDHAVPAAFPATDSTSEGKSVRHPKPSTSESKQSTPSETQ TVGAHVLQVCSEHTSHSAHPEPALNLTLASKEIPSKLEAQLGQGKGEAKLDLKYVPPRRVEQEGKAAQEGYLGCHKEENLSALEGRDPCG EAHPEATDALGHLLNSDLHHLGVGRGNCEEKRGVNPGEQDSLHTTPKQGSASLGGADNQPTGKISPCAGEKLGERTSSSFSPGDSHVAFI PNNLTDSKPLDVIEEERRLGSGNKDSVMVLVFNPSVGENKTEVPEPLDPQSGRSEARESKEVTTSVAENRNLLENADKIESTSARADSVL NIPAPLHPETTVNMTYQPTTPSSSFQDVSVFGMDAGSPLVVPPPTDSARLLNTSPKVPDKNTCPSGIPKPVFTHSKDTPSSQEGMENYQV EKTEERTETKPIIMPKPKHVRPKIITYIRRNPQALGQVDASLVPVGLPYAPPTCTMPLPHEEKAAGGDLKPSANLYEKFKPDLQKPRVFS SGLMVSGIKPPGHPFSQMSEKFLQEVTDHPGKEEFCSPPYAHYEVPPTFYRSAMLLKPQLGLGAMSRLPSAKSRILIASQRSSASAIHPP GPITTATSLYSSDPSADLKKASSSNAAKSNLPKSGLRPPGYSRLPAAKLAAFGFVRSSSVSSVSSTQSGDSAQPEQGRPATRSTFGNEEQ PVLKASLPSKDTPKGAGRVAPPASSSVTAPRRSLLPAPKSTSTPAGTKKDAQKDQDTNKPAVSSPKRVAASTTKLHSPGYPKQRTAAARN GFPPKPDPQAREAERQLVLRLKERCEQQTRQLGVAQGELKRAICGFDALAVATQHFFRKNESALVKEKELSIELANIRDEVAFHTAKCEK LQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVSRILRKAAAERSAEEGRLLAESADLV TELQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVSAADLSEAEPTLT HMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVH FGERGTLGQPLNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGL -------------------------------------------------------------- >In-frame_ENST00000380808_ENST00000328666_TCGA-DX-A8BK-01A_MTUS2_chr13_30054501_+_SIRT7_chr17_79875843_length(transcript)=2139nt_BP=552nt AGATCTGATCGCTGCTGCCCTGCTCTCCTCCTCCTCTCATTCCTCTGCCTCCTGGATTCCTGAAGTTTAGGAGAAATAAGGTAGCCAAGG GAACCACATGGAAGTTGTGACAGCTCCCAGCGGCGCGCCCCTTTCGTGTGTGCCGGTACCTCGGCTTAGGAGTTGCCCGCTGACACCTTG AATGAAGGAGGTCCCCTTGCCAGCCAGCCTGCCGGGATGGGCCATTGCTGCTGCAAGCCTTATAACTGCCTTCAGTGCCTGGACAAGACG AATGAAAGTGCCCTTGTGAAAGAAAAAGAGCTGTCAATCGAACTTGCAAACATCAGGGATGAAGTTGCCTTCCATACAGCAAAGTGCGAG AAACTACAAAAGGAGAAGGAGGAGCTGGAGAGGCGGTTCGAGGACGAGGTGAAGAGGCTGGGCTGGCAGCAGCAGGCCGAGCTCCAGGAG CTGGAGGAGCGGCTGCAGCTGCAATTCGAGGCGGAAATGGCGCGCCTGCAGGAGGAGCACGGTGACCAGCTGCTGAGCATCCGGTGTCAA CACCAGGAGCAGGTGTCGCGCATCCTGAGGAAGGCGGCGGCGGAGCGCAGCGCCGAGGAGGGCCGGCTGCTGGCCGAGAGCGCGGACCTG GTAACGGAGCTGCAGGGCCGGAGCCGGCGGCGCGAGGGCCTGAAGCGGCGGCAGGAGGAGGTGTGCGACGACCCGGAGGAGCTGCGGGGG AAGGTCCGGGAGCTGGCCAGCGCCGTCCGGAACGCCAAATACTTGGTCGTCTACACAGGCGCGGGAATCAGCACGGCAGCGTCTATCCCA GACTACCGGGGCCCTAATGGAGTGTGGACACTGCTTCAGAAAGGGAGAAGCGTTAGTGCTGCCGACCTGAGCGAGGCCGAGCCAACCCTC ACCCACATGAGCATCACCCGTCTGCATGAGCAGAAGCTGGTGCAGCATGTGGTGTCTCAGAACTGTGACGGGCTCCACCTGAGGAGTGGG CTGCCGCGCACGGCCATCTCCGAGCTCCACGGGAACATGTACATTGAAGTCTGTACCTCCTGCGTTCCCAACAGGGAGTACGTGCGGGTG TTCGATGTGACGGAGCGCACTGCCCTCCACAGACACCAGACAGGCCGGACCTGCCACAAGTGTGGGACCCAGCTGCGGGACACCATTGTG CACTTTGGGGAGAGGGGGACGTTGGGGCAGCCTTTGAACTGGGAAGCGGCGACCGAGGCTGCCAGCAGAGCAGACACCATCCTGTGTCTA GGGTCCAGCCTGAAGGTTCTAAAGAAGTACCCACGCCTCTGGTGCATGACCAAGCCCCCTAGCCGGCGGCCGAAGCTTTACATCGTGAAC CTGCAGTGGACCCCGAAGGATGACTGGGCTGCCCTGAAGCTACATGGGAAGTGTGATGACGTCATGCGGCTCCTCATGGCCGAGCTGGGC TTGGAGATCCCCGCCTATAGCAGGTGGCAGGATCCCATTTTCTCACTGGCGACTCCCCTGCGTGCTGGTGAAGAAGGCAGCCACAGTCGG AAGTCGCTGTGCAGAAGCAGAGAGGAGGCCCCGCCTGGGGACCGGGGTGCACCGCTTAGCTCGGCCCCCATCCTAGGGGGCTGGTTTGGC AGGGGCTGCACAAAACGCACAAAAAGGAAGAAAGTGACGTAATCACGTGCTCGATGAAGAACAGTTGGCACTTTGCAGATGGCCAGTGTC ACGGTGAAGGCTGGGTTGCCCCCACGGGTCTAGGGAGAACGAACTCTTTGGGGATGACATTTTCACCGTGACATTTTTAGCCATTTGTCC TTGAGGAAGCCCCTTGCACTGCTGCGGTTGTACCCTGATACGGCCTGGCCATCGAGGACACCTGCCCATCCGGCCTCTGTGTCAAGAGGT GGCAGCCGCACCTTTCTGTGAGAACGGAACTCGGGTTATTTCAGCCCCGGCCTGCAGAGTGGAAGCGCCCAGCGGCCTTTCCTCGCTCAC CAGGCCAGTCTCAGGGCCTCACCGTATTTCTACTACTACTTAATGAAAAAGTGTGAACTTTATAGAATCCTCTCTGTACTGGATGTGCGG >In-frame_ENST00000380808_ENST00000328666_TCGA-DX-A8BK-01A_MTUS2_chr13_30054501_+_SIRT7_chr17_79875843_length(amino acids)=499AA_start in transcript=162_stop in transcript=1661 MPADTLNEGGPLASQPAGMGHCCCKPYNCLQCLDKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQ QAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVSRILRKAAAERSAEEGRLLAESADLVTELQGRSRRREGLKRRQEEVCDD PEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDG LHLRSGLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASRA DTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYSRWQDPIFSLATPLRAGE -------------------------------------------------------------- >In-frame_ENST00000542829_ENST00000328666_TCGA-DX-A8BK-01A_MTUS2_chr13_30054501_+_SIRT7_chr17_79875843_length(transcript)=1990nt_BP=403nt AGCCAAGGGAACCACATGGAAGTTGTGACAGCTCCCAGCGGCGCGCCCCTTTCGTGTGTGCCGGTACCTCGGCTTAGGAGTTGCCCGCTG ACACCTTGAATGAAGGAGGTCCCCTTGCCAGCCAGCCTGCCGGGATGGGCCATTGCTGCTGCAAGCCTTATAACTGCCTTCAGTGCCTGG ACAAGACGCCTTCCATACAGCAAAGTGCGAGAAACTACAAAAGGAGAAGGAGGAGCTGGAGAGGCGGTTCGAGGACGAGGTGAAGAGGCT GGGCTGGCAGCAGCAGGCCGAGCTCCAGGAGCTGGAGGAGCGGCTGCAGCTGCAATTCGAGGCGGAAATGGCGCGCCTGCAGGAGGAGCA CGGTGACCAGCTGCTGAGCATCCGGTGTCAACACCAGGAGCAGGTGTCGCGCATCCTGAGGAAGGCGGCGGCGGAGCGCAGCGCCGAGGA GGGCCGGCTGCTGGCCGAGAGCGCGGACCTGGTAACGGAGCTGCAGGGCCGGAGCCGGCGGCGCGAGGGCCTGAAGCGGCGGCAGGAGGA GGTGTGCGACGACCCGGAGGAGCTGCGGGGGAAGGTCCGGGAGCTGGCCAGCGCCGTCCGGAACGCCAAATACTTGGTCGTCTACACAGG CGCGGGAATCAGCACGGCAGCGTCTATCCCAGACTACCGGGGCCCTAATGGAGTGTGGACACTGCTTCAGAAAGGGAGAAGCGTTAGTGC TGCCGACCTGAGCGAGGCCGAGCCAACCCTCACCCACATGAGCATCACCCGTCTGCATGAGCAGAAGCTGGTGCAGCATGTGGTGTCTCA GAACTGTGACGGGCTCCACCTGAGGAGTGGGCTGCCGCGCACGGCCATCTCCGAGCTCCACGGGAACATGTACATTGAAGTCTGTACCTC CTGCGTTCCCAACAGGGAGTACGTGCGGGTGTTCGATGTGACGGAGCGCACTGCCCTCCACAGACACCAGACAGGCCGGACCTGCCACAA GTGTGGGACCCAGCTGCGGGACACCATTGTGCACTTTGGGGAGAGGGGGACGTTGGGGCAGCCTTTGAACTGGGAAGCGGCGACCGAGGC TGCCAGCAGAGCAGACACCATCCTGTGTCTAGGGTCCAGCCTGAAGGTTCTAAAGAAGTACCCACGCCTCTGGTGCATGACCAAGCCCCC TAGCCGGCGGCCGAAGCTTTACATCGTGAACCTGCAGTGGACCCCGAAGGATGACTGGGCTGCCCTGAAGCTACATGGGAAGTGTGATGA CGTCATGCGGCTCCTCATGGCCGAGCTGGGCTTGGAGATCCCCGCCTATAGCAGGTGGCAGGATCCCATTTTCTCACTGGCGACTCCCCT GCGTGCTGGTGAAGAAGGCAGCCACAGTCGGAAGTCGCTGTGCAGAAGCAGAGAGGAGGCCCCGCCTGGGGACCGGGGTGCACCGCTTAG CTCGGCCCCCATCCTAGGGGGCTGGTTTGGCAGGGGCTGCACAAAACGCACAAAAAGGAAGAAAGTGACGTAATCACGTGCTCGATGAAG AACAGTTGGCACTTTGCAGATGGCCAGTGTCACGGTGAAGGCTGGGTTGCCCCCACGGGTCTAGGGAGAACGAACTCTTTGGGGATGACA TTTTCACCGTGACATTTTTAGCCATTTGTCCTTGAGGAAGCCCCTTGCACTGCTGCGGTTGTACCCTGATACGGCCTGGCCATCGAGGAC ACCTGCCCATCCGGCCTCTGTGTCAAGAGGTGGCAGCCGCACCTTTCTGTGAGAACGGAACTCGGGTTATTTCAGCCCCGGCCTGCAGAG TGGAAGCGCCCAGCGGCCTTTCCTCGCTCACCAGGCCAGTCTCAGGGCCTCACCGTATTTCTACTACTACTTAATGAAAAAGTGTGAACT TTATAGAATCCTCTCTGTACTGGATGTGCGGCAGAGGGGTGGCTCCGAGCCTCGGCTCTATGCAGACCTTTTTATTTCTATTAAACGTTT >In-frame_ENST00000542829_ENST00000328666_TCGA-DX-A8BK-01A_MTUS2_chr13_30054501_+_SIRT7_chr17_79875843_length(amino acids)=449AA_start in transcript=163_stop in transcript=1512 MPSVPGQDAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVSRILRKAAA ERSAEEGRLLAESADLVTELQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQK GRSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHRHQT GRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MTUS2-SIRT7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MTUS2-SIRT7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MTUS2-SIRT7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SIRT7 | C0015695 | Fatty Liver | 1 | CTD_human |
| Tgene | SIRT7 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Tgene | SIRT7 | C0036421 | Systemic Scleroderma | 1 | CTD_human |
| Tgene | SIRT7 | C2711227 | Steatohepatitis | 1 | CTD_human |
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