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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MUC13-SIAE (FusionGDB2 ID:55659)

Fusion Gene Summary for MUC13-SIAE

Fusion gene summary

Fusion gene information	Fusion gene name: MUC13-SIAE
	Fusion gene ID: 55659
		Hgene	Tgene
	Gene symbol	MUC13	SIAE
	Gene ID	56667	54414
	Gene name	mucin 13, cell surface associated	sialic acid acetylesterase
	Synonyms	DRCC1\|MUC-13	AIS6\|CSE-C\|CSEC\|LSE\|YSG2
	Cytomap	3q21.2	11q24.2
	Type of gene	protein-coding	protein-coding
	Description	mucin-13down-regulated in colon cancer 1mucin 13, epithelial transmembrane	sialate O-acetylesteraseH-Lsecytosolic sialic acid 9-O-acetylesterase homologsialic acid-specific acetylesterase II
	Modification date	20200322	20200313
	UniProtAcc	Q9H3R2	.
	Ensembl transtripts involved in fusion gene	ENST00000311075, ENST00000497378,	ENST00000263593, ENST00000545756, ENST00000525730,
Fusion gene scores	* DoF score	6 X 6 X 3=108	34 X 6 X 15=3060
	# samples	6	34
	** MAII score	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(34/3060*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MUC13 [Title/Abstract] AND SIAE [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MUC13(124624289)-SIAE(124543777), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SIAE	GO:0005975	carbohydrate metabolic process	23308225

Fusion gene breakpoints across MUC13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SIAE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8687-01A	MUC13	chr3	124624289	-	SIAE	chr11	124543777	-

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Fusion Gene ORF analysis for MUC13-SIAE

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000311075	ENST00000263593	MUC13	chr3	124624289	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000311075	ENST00000545756	MUC13	chr3	124624289	-	SIAE	chr11	124543777	-
5CDS-intron	ENST00000311075	ENST00000525730	MUC13	chr3	124624289	-	SIAE	chr11	124543777	-
intron-3CDS	ENST00000497378	ENST00000263593	MUC13	chr3	124624289	-	SIAE	chr11	124543777	-
intron-intron	ENST00000497378	ENST00000545756	MUC13	chr3	124624289	-	SIAE	chr11	124543777	-
intron-intron	ENST00000497378	ENST00000525730	MUC13	chr3	124624289	-	SIAE	chr11	124543777	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000311075

MUC13

chr3

124624289

ENST00000263593

SIAE

chr11

124543777

8459

2876

2863

4620

585

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000311075	ENST00000263593	MUC13	chr3	124624289	-	SIAE	chr11	124543777	-	0.000397096	0.999603

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Fusion Genomic Features for MUC13-SIAE

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MUC13-SIAE

Go to
FGviewer for the breakpoints of chr3:124624289-chr11:124543777
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MUC13 Q9H3R2	.
FUNCTION: Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MUC13

chr3:124624289

chr11:124543777

ENST00000311075

29_171

945.6666666666666

829.6666666666666

Compositional bias

Note=Thr-rich

Hgene

MUC13

chr3:124624289

chr11:124543777

ENST00000311075

173_211

945.6666666666666

829.6666666666666

Domain

EGF-like 1

Hgene

MUC13

chr3:124624289

chr11:124543777

ENST00000311075

212_336

945.6666666666666

829.6666666666666

Domain

SEA

Hgene

MUC13

chr3:124624289

chr11:124543777

ENST00000311075

322_361

945.6666666666666

829.6666666666666

Domain

EGF-like 2

Hgene

MUC13

chr3:124624289

chr11:124543777

ENST00000311075

363_404

945.6666666666666

829.6666666666666

Domain

EGF-like 3

Hgene

MUC13

chr3:124624289

chr11:124543777

ENST00000311075

19_421

945.6666666666666

829.6666666666666

Topological domain

Extracellular

Hgene

MUC13

chr3:124624289

chr11:124543777

ENST00000311075

443_512

945.6666666666666

829.6666666666666

Topological domain

Cytoplasmic

Hgene

MUC13

chr3:124624289

chr11:124543777

ENST00000311075

422_442

945.6666666666666

829.6666666666666

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MUC13-SIAE

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000311075_ENST00000263593_TCGA-BR-8687-01A_MUC13_chr3_124624289_-_SIAE_chr11_124543777_length(transcript)=8459nt_BP=2876nt
ATCATTTCCTCCTCAGATTACCAAGCAAGAACAGCTAAAATGAAAGCCATCATTCATCTTACTCTTCTTGCTCTCCTTTCTGTAAACACA
GCCACCAACCAAGGCAACTCAGCTGATGCTGTAACAACCACAGAAACTGCGACTAGTGGTCCTACAGTAGCTGCAGCTGATACCACTGAA
ACTAATTTCCCTGAAACTGCTAGCACCACAGCAAATACACCTTTCCCAACAGCTACTTCACCTGCTCCCCCCATAATTAGTACACATAGT
TCCTCCACAATTCCTACACCTGCTCCCCCCATAATTAGTACACATAGTTCCTCCACAATTCCTATACCTACTGCTGCAGACAGTGAGTCA
ACCACAAATGTAAATTCATTAGCTACCTCTGACATAATCACCGCTTCATCTCCAAATGATGGATTAATCACAATGGTTCCTTCTGAAACA
CAAAGTAACAATGAAATGTCCCCCACCACAGAAGACAATCAATCATCAGGGCCTCCCACTGGCACCGCTTTATTGGAGACCAGCACCCTA
AACAGCACAGGTCCCAGCAATCCTTGCCAAGATGATCCCTGTGCAGATAATTCGTTATGTGTTAAGCTGCATAATACAAGTTTTTGCCTG
TGTTTAGAAGGGTATTACTACAACTCTTCTACATGTAAGAAAGGAAAGGTATTCCCTGGGAAGATTTCAGTGACAGTATCAGAAACATTT
GACCCAGAAGAGAAACATTCCATGGCCTATCAAGACTTGCATAGTGAAATTACTAGCTTGTTTAAAGATGTATTTGGCACATCTGTTTAT
GGACAGACTGTAATTCTTACTGTAAGCACATCTCTGTCACCAAGATCTGAAATGCGTGCTGATGACAAGTTTGTTAATGTAACAATAGTA
ACAATTTTGGCAGAAACCACAAGTGACAATGAGAAGACTGTGACTGAGAAAATTAATAAAGCAATTAGAAGTAGCTCAAGCAACTTTCTA
AACTATGATTTGACCCTTCGGTGTGATTATTATGGCTGTAACCAGACTGCGGATGACTGCCTCAATGGTTTAGCATGCGATTGCAAATCT
GACCTGCAAAGGCCTAACCCACAGAGCCCTTTCTGCGTTGCTTCCAGTCTCAAGTGTCCTGATGCCTGCAACGCACAGCACAAGCAATGC
TTAATAAAGAAGAGTGGTGGGGCCCCTGAGTGTGCGTGCGTGCCCGGCTACCAGGAAGATGCTAATGGGAACTGCCAAAAGTGTGCATTT
GGCTACAGTGGACTCGACTGTAAGGACAAATTTCAGCTGATCCTCACTATTGTGGGCACCATCGCTGGCATTGTCATTCTCAGCATGATA
ATTGCATTGATTGTCACAGCAAGATCAAATAACAAAACGAAGCATATTGAAGAAGAGAACTTGATTGACGAAGACTTTCAAAATCTAAAA
CTGCGGTCGACAGGCTTCACCAATCTTGGAGCAGAAGGGAGCGTCTTTCCTAAGGTCAGGATAACGGCCTCCAGAGACAGCCAGATGCAA
AATCCCTATTCAAGACACAGCAGCATGCCCCGCCCTGACTATTAGAATCATAAGAATGTGGAACCCGCCATGGCCCCCAACCAATGTACA
AGCTATTATTTAGAGTGTTTAGAAAGACTGATGGAGAAGTGAGCACCAGTAAAGATCTGGCCTCCGGGGTTTTTCTTCCATCTGACATCT
GCCAGCCTCTCTGAATGGAAGTTGTGAATGTTTGCAACGAATCCAGCTCACTTGCTAAATAAGAATCTATGACATTAAATGTAGTAGATG
CTATTAGCGCTTGTCAGAGAGGTGGTTTTCTTCAATCAGTACAAAGTACTGAGACAATGGTTAGGGTTGTTTTCTTAATTCTTTTCCTGG
TAGGGCAACAAGAACCATTTCCAATCTAGAGGAAAGCTCCCCAGCATTGCTTGCTCCTGGGCAAACATTGCTCTTGAGTTAAGTGACCTA
ATTCCCCTGGGAGACATACGCATCAACTGTGGAGGTCCGAGGGGATGAGAAGGGATACCCACCATCTTTCAAGGGTCACAAGCTCACTCT
CTGACAAGTCAGAATAGGGACACTGCTTCTATCCCTCCAATGGAGAGATTCTGGCAACCTTTGAACAGCCCAGAGCTTGCAACCTAGCCT
CACCCAAGAAGACTGGAAAGAGACATATCTCTCAGCTTTTTCAGGAGGCGTGCCTGGGAATCCAGGAACTTTTTGATGCTAATTAGAAGG
CCTGGACTAAAAATGTCCACTATGGGGTGCACTCTACAGTTTTTGAAATGCTAGGAGGCAGAAGGGGCAGAGAGTAAAAAACATGACCTG
GTAGAAGGAAGAGAGGCAAAGGAAACTGGGTGGGGAGGATCAATTAGAGAGGAGGCACCTGGGATCCACCTTCTTCCTTAGGTCCCCTCC
TCCATCAGCAAAGGAGCACTTCTCTAATCATGCCCTCCCGAAGACTGGCTGGGAGAAGGTTTAAAAACAAAAAATCCAGGAGTAAGAGCC
TTAGGTCAGTTTGAAATTGGAGACAAACTGTCTGGCAAAGGGTGCGAGAGGGAGCTTGTGCTCAGGAGTCCAGCCGTCCAGCCTCGGGGT
GTAGGTTTCTGAGGTGTGCCATTGGGGCCTCAGCCTTCTCTGGTGACAGAGGCTCAGCTGTGGCCACCAACACACAACCACACACACACA
ACCACACACACAAATGGGGGCAACCACATCCAGTACAAGCTTTTACAAATGTTATTAGTGTCCTTTTTTATTTCTAATGCCTTGTCCTCT
TAAAAGTTATTTTATTTGTTATTATTATTTGTTCTTGACTGTTAATTGTGAATGGTAATGCAATAAAGTGCCTTTGTTAGATGGTGAAAA
AAAAAAAAAAACTACGGCGGCCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCGAGGACTGCAAAAGGGTGGAGTC
GGCCTCGCCCCCGCCCAGGCCCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGATCCTTGCAAGCATGGTCGCGCC
GGGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCGCTTTGCTTCATACATCAATAA
TGATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGTGACCGTGACCCTGCGCCAAGG
TCAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGATCCTATGAAGCCTGGAGGACC
TTTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTTTGGAGATGTCTGGCTCTGTAG
TGGGCAGAGTAACATGCAGATGACTGTGTTACAGATATTTAATGCTACAAGGGAGTTGTCTAACACTGCGGCATATCAGTCTGTCCGCAT
CCTCTCTGTCTCTCCCATTCAAGCAGAGCAGGAGCTGGAGGACCTTGTTGCGGTTGACTTGCAGTGGTCTAAGCCCACCTCAGAAAACTT
AGGCCATGGATATTTCAAGTACATGTCAGCAGTGTGCTGGCTCTTTGGACGTCACCTTTATGACACTCTGCAGTATCCCATCGGGCTGAT
CGCCTCCAGCTGGGGCGGGACACCCATTGAAGCCTGGTCATCTGGACGGTCACTGAAAGCCTGTGGGGTCCCTAAACAAGGGTCCATTCC
ATACGATTCTGTAACTGGTCCCAGTAAGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTGTGCAATATGACTCTGAAAGGGGTAGT
ATGGTACCAGGGGGAGTCCAATATAAATTATAACACGGATCTGTACAATTGCACATTCCCTGCACTCATCGAAGACTGGCGTGAAACCTT
CCACCGTGGTTCCCAGGGGCAGACGGAGCGTTTCTTCCCATTTGGACTTGTCCAGTTATCTTCAGATTTGTCTAAGAAGAGCTCAGACGA
TGGATTTCCCCAGATCCGTTGGCATCAAACAGCAGACTTCGGCTATGTCCCCAACCCAAAGATGCCCAATACTTTCATGGCTGTAGCTAT
GGATCTCTGTGATAGAGACTCGCCTTTTGGCAGCATCCACCCTCGAGATAAACAGACTGTGGCTTATCGGCTGCATTTGGGGGCCCGTGC
TCTGGCTTATGGTGAGAAGAATTTGACCTTTGAAGGACCACTGCCTGAGAAGATAGAACTCTTGGCTCACAAGGGGCTGCTCAATCTCAC
ATATTACCAGCAAATCCAGGTGCAGAAAAAGGACAACAAGATATTTGAGATCTCCTGTTGCAGTGACCATCGATGCAAGTGGCTTCCAGC
TTCTATGAACACCGTCTCCACCCAGTCCCTGACCCTGGCGATCGATTCTTGTCATGGCACTGTGGTTGCTCTCCGCTATGCTTGGACCAC
GTGGCCTTGTGAATATAAGCAGTGTCCCCTATACCACCCCAGTAGTGCCCTGCCAGCCCCTCCCTTCATTGCTTTCATTACAGACCAGGG
TCCTGGACATCAGAGCAATGTTGCTAAATGACTGTTTCAGTATGATCAGAACTTAGATATAAGGATGGGTCCTTCAGATTTTAGCATTTA
GGAGTTTCAATAATAACCATTGCTTTTAAAGGAAATTAATAGAAAGCCTCATTGAATGGCTTTCAGCTAGCACATGGCTGTTTCTATATT
CTGATGAGCCCAGGCTTATAGGTAACTTGAAATGCTTGCTTTTTGTTCCCTAGTTGGTCTAAGGGTCTGTATTGGACTAATTCTGAACTA
CAGACAAATTGGACCTCAATGTCATTTACTTCCCTCATATTAATGGGAGTGAAATGTCTAATACTTTTGCCCCTTTTTATCCAGAGTTGT
GGGAATCTCAGGATTGGAAGAGATTTTAAAGGCCACATAGGCCAGCTAGTGTTCATGTGTTCTTTATAAAATTTCTCCCATCCAAGTACT
AACCAGGCCCGACCCTGCTTAGCTTCCGAGATCAGATGAGATCAGGCGCGTTCAGGGTGATATGGCCGTAGACGTCTTTACAAAATTCCT
GACAGGTGGTTACTGAATCTCTCTATGAACTTTCCATTCAAAACTTTCCAAGTTTTTCCTTATGTGGAACCGAAATCTTTCTTTCTCCCG
TGAAACTTTACTACTATCAGATAATTGAAGACAGATCTCTTTGTATTCTCTTCAAGCCCAAACCAATTCTGTTCCTTCAATCTAAATAGT
GGTAATATGAATGTTTAAGAAATGAAATAAGAAACATGTGCAGGCACTTTGGAAGGTGCTAAGTGACTGCCCTAAGGAATGAAAAGCAAG
GGCCAGGTGGGAGTAGCCCAGCGAAGGCACTTGGGCTGCCAGGAACAGGAGGCGTGGGAAACTCTGGCTTAGGAAAACATGAACACAGGG
GCAACAGAGGCAAACTGTTGTTCGAGTTAAATATAAATCTCAGGCTCTTTAAAGGTAAAAGGTTTAAGGATAATCCATTTGGAAGAAGAA
AAGAGTGAGGCTGAAAGTAAAGCCACATGACAAGCATATAAAAAAAAATGCAGATGATACAAATATGAAAGAGGCCTTCAGTGTTTGTTT
ATTAAGAATCTTAATGCAGTTTACTGATGGATTAAAAACAGCTAACATTGTCTGAAAATTATGTTACCTATAAGAAGTTGGAAATAAATA
AAAGCATAATCACTAGTGATGTGTATGTATTTATATCCACTTGCAAACTGTCCTTGAAGCATGTGAAAAGGAGTAAGAATACTATCTATG
GGTAGCTTTCCTCCCCTTAATGTGAAAAATGAGAACTAAAGCAAAAAGCATCACTCACTGTACATATACAATGTATTTTACGTAGTGTAA
AAAATATGGTTTAGATAGTGAATATATTAATGAAATCATATGTAAATTTATTTTTAGTGGCTGAATAATTTAAAACATTATGTGGAATTC
ACTATGTTTCCCCCAATTTAGGAACTTTTTACTGTGTGAAAATGAAATTTATAATACTCTGTAGGGTGAATGATGGTTTTTGCTTTAGTT
CTACCCCTCTGTAGAGTTCCAAGGGGTTCTGGTGTAGCTCCAAACAGCAGGAATAACTTTGTCAGTGCCAAGATTTTATTTAGTTAAAAA
ACAAAAAATCTACACACTTTACAAGGAACGTTGGCTCCCCTGAGGACTTCCTAGCATTCAACTCGTTCAGTTAACCCCTATTGCCCATGC
TTTGACCTCTCATGCATCTGGCCCCATAGAAACCATGAACCTTGTAACAGATTGATGCCTGAGAAAAAGTCAATCTACCCGTCCACTCCT
CCACTCCCAATACACATACCCCCATGGGCTGTTCTAATTCGGGGGCAGCCAGAGGTAGCCAAGAACTCTAAGTCCAGATTCCTTTCACCT
CCAGGAACCTAGAGTACATAGTGTGAAAAATACGGTTCAGGCAATGATTATGTTAATGACGCCATGCACATTCATTTTTAGTGGCTGAGT
AATTTAAAACATGATGTGGGAATTCACTGCATTTCCCCAAATGTAAGAACTTTTTAGTTTTAAAATGAAATTTATAGTCACTGTAGAAAA
TTTGGACACTAAAGTATAAGCAAGTAAAAATCACCCCCAAATTCATCATTCAGAGAAACACTATTTTGCTGAACCATTCACTTGACTTGA
GTTATATAATTTTATACAGTACATATTATTTTGTAATCTGTGTTTTTGACTTACTTACTTTACCAAAATAATTTTCTTATGTAAATAATA
GAATATAGATTTAGAGTGTTTCAGTTTGTGGAAGCCTCATTTTATTTAACCAATTTCCTATTAATGGACATATAGATTTTTAACAATTTT
CTACTATTAAAATAATACTGTAATGAATATCACATGCAAACATCATACCACACTCGTCCAGTTATTTCTTAGGGTTCTTAACATGGAAGA
GGATAAATATATATTTAAAATTTAGATATCTACAGCTTAACCCTCCCAAAGGATTAAACAACTTACATTCTCACCAAGGTAGTCCTTTTT
TTGCCCTCACCCTCATTGACACTGGATGTTGTCAAATTTAAAAAAAATCCTTAACAATCTGATAGATGAAAAGATAGTTTAAGTATACTA
AGGCAGTGTTTTTCAAGGTGTTTTTGTTTTTGTTTTTGAGTTGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGGTCTCGG
CTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCGTGCCACCACGCC
TGGCTAATTTTTTGTATTTTTATTAGAGACCGACTTAGCCAGGATGGTCTCGATCTCCTGACCTCTTGATCCACCCGCCTCAGCCTCCCA
AAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCAGCTTTTCAAGTTTCTTAAATCCATGATCCATAGTAAAAACATTTTACACATATC
TTCATACAAGTATATGTATATGTGGTATACGTACACACTATAGTTGTATATGCATTATAGCTGAAAAACCAGTTCAACCTTTCTACATGT
GGTATGTTCCAAAAATTTTAAATGTCTTTCTAAAATGAGGCTCTTTTAATACGGGTATTACTCAGGCTGTAATAGTGGGAAAATATTTGT
TATATGATAAAAGCAGCATATATCATTTCTGTGTAAATGCCAGTATGCTCAAGCCATTTATGCAGAGAAAAAAAGAAAAACACTGCATTA
ACATTTTAAGCAGTCCCCTTCCCGATTTGCTATTATACAAAGTTTGTTTCTTTTACATTGTAAAGTGTATACAACTTATAAAAAGACTAT
ACTCAAAATCATAAAATACCAGTTAACTTAGCTTCTCAGTTTACAGTGGCCAGTGTGGTGTGCTCTAAACACTGCTGCCTGATCCCTCCC
TCTGCTGGTCAGATTTATTACTATAAAGTACCAATCCCATTTGTGTTGTCCTCAATTGGCAATTATGAATGGCAGTGCATTAACCATTCA
ATTCTCACCACTCCATCCCCATTCTTCTACTTCTGGGTCCTTTTGTCCCTCCCTTTCCAGACAGCCCTTGGTAACCTGCTGCTGGGTAAC
TAAGGCATCCCACAGGTAGTGTTGAGGTGTTAGGTGATAGAGTAAACCTCTACCTTAATGCTATTAACAGGGTCCAAAAATCCAGTTGCA
TGGAACATGGAGTTATATTATTACATGGCTAATGAAAAGACAGGACTAAGTCTGTTATAGAGTATGGGACTAACCCCCAATTATATGTGA

>In-frame_ENST00000311075_ENST00000263593_TCGA-BR-8687-01A_MUC13_chr3_124624289_-_SIAE_chr11_124543777_length(amino acids)=585AA_start in transcript=2863_stop in transcript=4620
MLDGEKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPLILWADRSAGIGFRF
ASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLEKINFTLRVHDVLFG
DVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSAVCWLFGRHLYDTLQ
YPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINYNTDLYNCTFPALIE
DWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFGSIHPRDKQTVAYRL
HLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSLTLAIDSCHGTVVAL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MUC13-SIAE

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MUC13-SIAE

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MUC13-SIAE

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	SIAE	C3150797	AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6	1	UNIPROT