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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYBBP1A-BAG6 (FusionGDB2 ID:55833)

Fusion Gene Summary for MYBBP1A-BAG6

check button Fusion gene summary
Fusion gene informationFusion gene name: MYBBP1A-BAG6
Fusion gene ID: 55833
HgeneTgene
Gene symbol

MYBBP1A

BAG6

Gene ID

10514

7917

Gene nameMYB binding protein 1aBAG cochaperone 6
SynonymsP160|PAP2|Pol5BAG-6|BAT3|D6S52E|G3
Cytomap

17p13.2

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionmyb-binding protein 1AMYB binding protein (P160) 1ap53-activated protein-2large proline-rich protein BAG6BAG family molecular chaperone regulator 6BCL2 associated athanogene 6HLA-B-associated transcript 3large proline-rich protein BAT3protein G3protein Scythescythe
Modification date2020031320200313
UniProtAcc

Q9BQG0

P46379

Ensembl transtripts involved in fusion geneENST00000381556, ENST00000254718, 
ENST00000375976, ENST00000211379, 
ENST00000439687, ENST00000404765, 
ENST00000375964, ENST00000362049, 
ENST00000470875, ENST00000442479, 
ENST00000449450, ENST00000417144, 
ENST00000551350, ENST00000497694, 
ENST00000422756, ENST00000425649, 
ENST00000434446, ENST00000552467, 
ENST00000463220, ENST00000413922, 
ENST00000454478, ENST00000412012, 
ENST00000546462, ENST00000460147, 
ENST00000383446, ENST00000361076, 
ENST00000383448, ENST00000552605, 
ENST00000471376, ENST00000415373, 
ENST00000444402, ENST00000415345, 
ENST00000550393, ENST00000461852, 
ENST00000443182, ENST00000451932, 
ENST00000419847, ENST00000552116, 
ENST00000460429, 
Fusion gene scores* DoF score6 X 7 X 3=1267 X 6 X 3=126
# samples 67
** MAII scorelog2(6/126*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYBBP1A [Title/Abstract] AND BAG6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYBBP1A(4451891)-BAG6(31615388), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYBBP1A

GO:0042149

cellular response to glucose starvation

21471221

TgeneBAG6

GO:0002429

immune response-activating cell surface receptor signaling pathway

18852879

TgeneBAG6

GO:0006915

apoptotic process

14960581

TgeneBAG6

GO:0018393

internal peptidyl-lysine acetylation

17403783

TgeneBAG6

GO:0030101

natural killer cell activation

18852879

TgeneBAG6

GO:0030433

ubiquitin-dependent ERAD pathway

23129660|24981174

TgeneBAG6

GO:0071712

ER-associated misfolded protein catabolic process

23129660|24981174

TgeneBAG6

GO:0071816

tail-anchored membrane protein insertion into ER membrane

20676083|25535373


check buttonFusion gene breakpoints across MYBBP1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BAG6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF923713MYBBP1Achr17

4451891

-BAG6chr6

31615388

-


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Fusion Gene ORF analysis for MYBBP1A-BAG6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000381556ENST00000375976MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-3CDSENST00000381556ENST00000211379MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-3CDSENST00000381556ENST00000439687MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-3CDSENST00000381556ENST00000404765MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-3CDSENST00000381556ENST00000375964MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-3CDSENST00000381556ENST00000362049MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000470875MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000442479MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000449450MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000417144MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000551350MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000497694MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000422756MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000425649MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000434446MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000552467MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000463220MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000413922MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000454478MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000412012MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000546462MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000460147MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000383446MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000361076MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000383448MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000552605MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000471376MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000415373MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000444402MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000415345MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000550393MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000461852MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000443182MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000451932MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000419847MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000552116MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000381556ENST00000460429MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-3CDSENST00000254718ENST00000375976MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-3CDSENST00000254718ENST00000211379MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-3CDSENST00000254718ENST00000439687MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-3CDSENST00000254718ENST00000404765MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-3CDSENST00000254718ENST00000375964MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-3CDSENST00000254718ENST00000362049MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000470875MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000442479MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000449450MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000417144MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000551350MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000497694MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000422756MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000425649MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000434446MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000552467MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000463220MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000413922MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000454478MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000412012MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000546462MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000460147MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000383446MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000361076MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000383448MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000552605MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000471376MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000415373MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000444402MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000415345MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000550393MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000461852MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000443182MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000451932MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000419847MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000552116MYBBP1Achr17

4451891

-BAG6chr6

31615388

-
intron-intronENST00000254718ENST00000460429MYBBP1Achr17

4451891

-BAG6chr6

31615388

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MYBBP1A-BAG6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYBBP1A-BAG6


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYBBP1A

Q9BQG0

BAG6

P46379

FUNCTION: May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}.FUNCTION: ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:28104892, PubMed:27193484). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MYBBP1A-BAG6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MYBBP1A-BAG6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYBBP1A-BAG6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYBBP1A-BAG6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYBBP1AC0033578Prostatic Neoplasms1CTD_human
HgeneMYBBP1AC0376358Malignant neoplasm of prostate1CTD_human