FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MYCBP2-PIBF1 (FusionGDB2 ID:55900)

Fusion Gene Summary for MYCBP2-PIBF1

check button Fusion gene summary
Fusion gene informationFusion gene name: MYCBP2-PIBF1
Fusion gene ID: 55900
HgeneTgene
Gene symbol

MYCBP2

PIBF1

Gene ID

23077

10464

Gene nameMYC binding protein 2progesterone immunomodulatory binding factor 1
SynonymsMyc-bp2|PAM|PHR1|PhrC13orf24|CEP90|JBTS33|PIBF
Cytomap

13q22.3

13q21.33-q22.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MYCBP2HighwireMYC binding protein 2, E3 ubiquitin protein ligasePAM/Highwire/RPM-1 protein 1RING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Mycprogesterone-induced-blocking factor 1centrosomal protein of 90 kDa
Modification date2020031320200313
UniProtAcc

O75592

.
Ensembl transtripts involved in fusion geneENST00000544440, ENST00000407578, 
ENST00000357337, ENST00000360084, 
ENST00000482517, 		ENST00000326291, 
ENST00000489922, 
Fusion gene scores* DoF score14 X 16 X 8=179216 X 13 X 13=2704
# samples 1523
** MAII scorelog2(15/1792*10)=-3.57853623156172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2704*10)=-3.55538938533781
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYCBP2 [Title/Abstract] AND PIBF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYCBP2(77730193)-PIBF1(73547729), # samples:2
Anticipated loss of major functional domain due to fusion event.MYCBP2-PIBF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYCBP2

GO:0016567

protein ubiquitination

29643511

HgeneMYCBP2

GO:0031398

positive regulation of protein ubiquitination

20534529

TgenePIBF1

GO:0031393

negative regulation of prostaglandin biosynthetic process

3863495

TgenePIBF1

GO:0032695

negative regulation of interleukin-12 production

14634107

TgenePIBF1

GO:0032733

positive regulation of interleukin-10 production

14634107

TgenePIBF1

GO:0032815

negative regulation of natural killer cell activation

12516630

TgenePIBF1

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

16393965

TgenePIBF1

GO:0042532

negative regulation of tyrosine phosphorylation of STAT protein

16393965

TgenePIBF1

GO:0042976

activation of Janus kinase activity

16393965


check buttonFusion gene breakpoints across MYCBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PIBF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-QH-A6X9-01AMYCBP2chr13

77730193

-PIBF1chr13

73547729

+
ChimerDB4LGGTCGA-QH-A6X9MYCBP2chr13

77730193

-PIBF1chr13

73547729

+
ChimerDB4LGGTCGA-QH-A6X9-01AMYCBP2chr13

77730193

-PIBF1chr13

73572960

+


Top

Fusion Gene ORF analysis for MYCBP2-PIBF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000544440ENST00000326291MYCBP2chr13

77730193

-PIBF1chr13

73547729

+
5CDS-3UTRENST00000544440ENST00000489922MYCBP2chr13

77730193

-PIBF1chr13

73547729

+
Frame-shiftENST00000407578ENST00000326291MYCBP2chr13

77730193

-PIBF1chr13

73547729

+
5CDS-3UTRENST00000407578ENST00000489922MYCBP2chr13

77730193

-PIBF1chr13

73547729

+
Frame-shiftENST00000357337ENST00000326291MYCBP2chr13

77730193

-PIBF1chr13

73547729

+
5CDS-3UTRENST00000357337ENST00000489922MYCBP2chr13

77730193

-PIBF1chr13

73547729

+
5UTR-3CDSENST00000360084ENST00000326291MYCBP2chr13

77730193

-PIBF1chr13

73547729

+
5UTR-3UTRENST00000360084ENST00000489922MYCBP2chr13

77730193

-PIBF1chr13

73547729

+
intron-3CDSENST00000482517ENST00000326291MYCBP2chr13

77730193

-PIBF1chr13

73547729

+
intron-3UTRENST00000482517ENST00000489922MYCBP2chr13

77730193

-PIBF1chr13

73547729

+
In-frameENST00000544440ENST00000326291MYCBP2chr13

77730193

-PIBF1chr13

73572960

+
5CDS-3UTRENST00000544440ENST00000489922MYCBP2chr13

77730193

-PIBF1chr13

73572960

+
In-frameENST00000407578ENST00000326291MYCBP2chr13

77730193

-PIBF1chr13

73572960

+
5CDS-3UTRENST00000407578ENST00000489922MYCBP2chr13

77730193

-PIBF1chr13

73572960

+
Frame-shiftENST00000357337ENST00000326291MYCBP2chr13

77730193

-PIBF1chr13

73572960

+
5CDS-3UTRENST00000357337ENST00000489922MYCBP2chr13

77730193

-PIBF1chr13

73572960

+
5UTR-3CDSENST00000360084ENST00000326291MYCBP2chr13

77730193

-PIBF1chr13

73572960

+
5UTR-3UTRENST00000360084ENST00000489922MYCBP2chr13

77730193

-PIBF1chr13

73572960

+
intron-3CDSENST00000482517ENST00000326291MYCBP2chr13

77730193

-PIBF1chr13

73572960

+
intron-3UTRENST00000482517ENST00000489922MYCBP2chr13

77730193

-PIBF1chr13

73572960

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544440MYCBP2chr1377730193-ENST00000326291PIBF1chr1373572960+757868191270432343
ENST00000407578MYCBP2chr1377730193-ENST00000326291PIBF1chr1373572960+7941718218374062407

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544440ENST00000326291MYCBP2chr1377730193-PIBF1chr1373572960+0.0002532490.99974674
ENST00000407578ENST00000326291MYCBP2chr1377730193-PIBF1chr1373572960+0.0003588920.99964106

Top

Fusion Genomic Features for MYCBP2-PIBF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MYCBP2-PIBF1


check button Go to

FGviewer for the breakpoints of chr13:77730193-chr13:73572960

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYCBP2

O75592

.
FUNCTION: Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (By similarity). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity). Regulates axon guidance in the olfactory system (By similarity). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (By similarity). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (PubMed:29643511). Regulates the internalization of TRPV1 in peripheral sensory neurons (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (PubMed:18308511, PubMed:27278822). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (PubMed:9689053). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). {ECO:0000250|UniProtKB:Q7TPH6, ECO:0000269|PubMed:18308511, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26304119, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:29643511, ECO:0000269|PubMed:9689053}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-4784103_1262267.04641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-4784766_8142267.04641.0Compositional biasCys-rich
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-4683103_1262267.04641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-4683766_8142267.04641.0Compositional biasCys-rich
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-47841235_13862267.04641.0RegionPHR domain 1
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-47841726_18842267.04641.0RegionPHR domain 2
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-46831235_13862267.04641.0RegionPHR domain 1
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-46831726_18842267.04641.0RegionPHR domain 2
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-47841010_10662267.04641.0RepeatRCC1 5
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-4784600_6552267.04641.0RepeatRCC1 1
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-4784699_7552267.04641.0RepeatRCC1 2
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-4784907_9572267.04641.0RepeatRCC1 3
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-4784958_10082267.04641.0RepeatRCC1 4
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-46831010_10662267.04641.0RepeatRCC1 5
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-4683600_6552267.04641.0RepeatRCC1 1
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-4683699_7552267.04641.0RepeatRCC1 2
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-4683907_9572267.04641.0RepeatRCC1 3
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-4683958_10082267.04641.0RepeatRCC1 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-47842720_28442267.04641.0Compositional biasSer-rich
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-47843194_32152267.04641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-47843262_32932267.04641.0Compositional biasNote=Gly-rich
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-46832720_28442267.04641.0Compositional biasSer-rich
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-46833194_32152267.04641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-46833262_32932267.04641.0Compositional biasNote=Gly-rich
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-47843719_38972267.04641.0DomainDOC
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-46833719_38972267.04641.0DomainDOC
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-47842022_25502267.04641.0RegionRAE1 binding
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-47844539_46762267.04641.0RegionTandem cysteine domain
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-46832022_25502267.04641.0RegionRAE1 binding
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-46834539_46762267.04641.0RegionTandem cysteine domain
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-47842341_24432267.04641.0RepeatFilamin
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-46832341_24432267.04641.0RepeatFilamin
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000357337-47844428_44792267.04641.0Zinc fingerRING-type%3B atypical
HgeneMYCBP2chr13:77730193chr13:73572960ENST00000544440-46834428_44792267.04641.0Zinc fingerRING-type%3B atypical
TgenePIBF1chr13:77730193chr13:73572960ENST0000032629115181_184683.0758.0RegionSufficient for NK inhibitory function
TgenePIBF1chr13:77730193chr13:73572960ENST0000032629115181_419683.0758.0RegionMediates modulation of Th2 dominant cytokine production


Top

Fusion Gene Sequence for MYCBP2-PIBF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000544440_ENST00000326291_TCGA-QH-A6X9-01A_MYCBP2_chr13_77730193_-_PIBF1_chr13_73572960_length(transcript)=7578nt_BP=6819nt
GCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGT
CACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGC
GGCAGCGCTGGACACCCAGCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTGAAG
ACAAGAAGCAAGTCTGAAAACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTACTGT
AATGTACGCCATTGCGTTCTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCAGAT
AGTGATGAAGAAGAGGAATCCAAAGAGCCCCCTATCAAGCTTCCAAAGATTATTGAGGTTGGCCTTTGTGAAGTTTTTGAATTGATCAAA
GAGACACGATTTTCTCATCCATCCCTGTGTCTCAGGAGTCTCCAAGCCCTGCTCAACGTGCTGCAGGGCCAGCAGCCAGAAGGCCTCCAG
TCTGAGCCACCTGAGGTCCTAGAGTCTCTCTTCCAGCTTCTTTTGGAAATCACCGTTCGAAGTACTGGGATGAATGACAGCACAGGACAG
TCCTTAACAGCACTTTCCTGTGCTTGCCTCTTTAGTCTGGTGGCTTCTTGGGGAGAAACAGGAAGGACACTTCAGGCCATCTCTGCTATC
CTCACCAACAATGGAAGCCATGCTTGCCAAACTATTCAGGTGCCAACAATTCTAAATTCGCTACAGAGAAGTGTACAAGCAGTTTTGGTG
GGAAAAATTCAAATTCAGGACTGGTTTAGTAATGGCATTAAGAAAGCAGCTTTAATGCACAAGTGGCCATTAAAAGAAATATCTGTTGAT
GAAGATGACCAATGTCTACTTCAGAATGATGGATTTTTTCTTTATCTATTATGCAAGGATGGATTATATAAAATAGGCTCTGGATACAGT
GGAACAGTTAGGGGCCATATATACAATTCTACATCCCGTATTAGAAACAGAAAAGAAAAAAAGTCTTGGTTAGGGTATGCTCAGGGTTAT
TTATTATATAGAGATGTGAATAACCACAGCATGACAGCCATAAGGATAAGCCCTGAAACACTGGAGCAAGATGGTACTGTGATGTTACCA
GATTGCCACACTGAAGGTCAAAATATTTTATTCACTGATGGAGAATATATTAATCAGATAGCTGCTTCAAGAGATGATGGCTTTGTTGTC
AGAATATTTGCCACAAGCACTGAACCTGTTCTACAGCAAGAATTGCAACTTAAACTGGCTAGAAAATGCTTACATGCCTGTGGTATCTCA
CTATTCGATCTGGAAAAGGACTTGCATATTATAAGTACAGGATTTGATGAGGAGTCAGCAATTCTTGGTGCAGGACGAGAGTTTGCGCTA
ATGAAAACAGCAAATGGAAAGATATATTACACTGGCAAATACCAGAGTCTTGGAATCAAACAAGGTGGTCCTTCAGCAGGAAAATGGGTT
GAGCTACCAATTACAAAATCTCCAAAGATAGTACACTTCTCAGTTGGACACGATGGCTCTCACGCCCTTTTAGTTGCAGAAGATGGGAGC
ATATTCTTTACAGGATCTGCTAGTAAAGGAGAAGATGGAGAATCAACTAAGAGCAGACGGCAATCCAAACCTTATAAACCTAAAAAGATA
ATTAAGATGGAAGGAAAGATTGTGGTATATACAGCCTGCAATAATGGAAGTAGTTCTGTTATTTCTAAAGATGGAGAACTCTACATGTTT
GGAAAAGATGCCATTTACTCTGATAGTTCAAGTTTGGTAACTGATTTGAAGGGCCATTTTGTAACTCAGGTAGCTATGGGCAAAGCTCAC
ACTTGTGTTTTAATGAAGAATGGAGAGGTGTGGACATTTGGTGTAAATAATAAAGGACAGTGTGGACGAGATACTGGTGCCATGAACCAA
GGTGGGAAAGGGTTTGGAGTTGAAAATATGGCAACAGCAATGGATGAAGACCTGGAAGAAGAACTAGATGAAAAAGATGAGAAGTCTATG
ATGTGCCCTCCAGGCATGCACAAATGGAAGCTGGAGCAGTGCATGGTTTGCACTGTCTGTGGAGACTGTACAGGTTATGGAGCCAGCTGT
GTCAGTAGTGGACGGCCAGACAGAGTCCCCGGAGGGATCTGTGGTTGTGGTTCCGGAGAATCTGGTTGTGCTGTGTGTGGATGTTGCAAG
GCCTGTGCAAGAGAGTTAGATGGTCAAGAGGCAAGACAAAGAGGAATTCTTGATGCAGTGAAAGAAATGATACCTTTAGATCTTCTTTTA
GCTGTCCCAGTGCCCGGGGTTAACATTGAAGAACACCTTCAGTTACGACAAGAAGAAAAACGGCAACGTGTAATCAGAAGGCACAGATTA
GAGGAAGGAAGAGGCCCCCTTGTATTTGCTGGTCCTATTTTTATGAACCATCGAGAACAGGCTCTAGCCAGACTCAGATCCCATCCAGCA
CAGCTAAAGCATAAACGGGACAAGCACAAAGATGGAAGTGGAGAAAGAGGCGAAAAGGATGCAAGCAAAATCACAACATACCCTCCAGGC
TCTGTGCGATTTGACTGTGAGCTCCGGGCAGTCCAAGTCAGCTGTGGATTTCACCATTCAGTGGTTTTAATGGAAAATGGAGATGTCTAT
ACATTTGGTTATGGGCAGCATGGGCAGCTAGGACATGGAGATGTCAACTCCAGGGGATGTCCCACTCTTGTTCAAGCATTGCCAGGCCCT
AGCACACAAGTCACTGCAGGCAGCAACCATACGGCAGTACTTTTAATGGATGGACAGGTCTTCACATTTGGAAGTTTTTCTAAAGGACAA
CTGGGCAGACCAATTTTGGATGTGCCATATTGGAATGCAAAGCCAGCTCCCATGCCTAACATTGGATCAAAATATGGAAGAAAAGCTACT
TGGATAGGTGCAAGTGGGGACCAAACTTTTTTACGAATTGATGAAGCACTTATTAATTCTCATGTACTTGCTACATCAGAAATTTTTGCC
AGTAAACACATAATAGGCTTGGTACCTGCTTCTATATCAGAACCTCCTCCATTTAAATGCCTTCTGATAAATAAAGTGGATGGGAGTTGT
AAAACTTTTAATGACTCAGAACAAGAGGATCTGCAAGGATTTGGTGTGTGTCTTGATCCTGTATATGATGTAATTTGGAGGTTTCGACCA
AATACTAGAGAGCTGTGGTGTTACAATGCGGTGGTTGCTGATGCCAGGCTTCCCTCTGCAGCAGACATGCAGTCCAGATGTAGTATCCTA
AGTCCTGAACTTGCCTTACCAACAGGATCAAGGGCCCTCACTACCCGATCTCATGCAGCTTTGCACATTTTAGGTTGTCTTGATACCTTG
GCAGCTATGCAGGACTTAAAAATGGGTGTTGCAAGTACAGAGGAAGAGACTCAAGCAGTAATGAAGGTTTATTCTAAAGAAGATTATAGT
GTGGTAAACAGGTTTGAAAGTCATGGAGGAGGCTGGGGTTATTCTGCCCATTCAGTAGAAGCTATACGTTTCAGTGCCGACACTGATATT
TTACTTGGTGGTCTTGGTCTGTTTGGAGGTAGAGGAGAATATACTGCTAAAATTAAGCTGTTTGAATTGGGTCCTGATGGAGGAGATCAT
GAAACTGATGGTGACCTTCTTGCAGAGACTGATGTATTGGCTTATGACTGTGCTGCTAGAGAAAAATATGCAATGATGTTTGATGAGCCT
GTTCTCCTGCAAGCTGGGTGGTGGTATGTGGCATGGGCCCGAGTGTCAGGACCCAGCAGTGACTGTGGATCTCATGGACAGGCATCTATT
ACCACAGATGATGGGGTTGTTTTCCAGTTCAAGAGTTCAAAGAAATCAAATAATGGTACAGATGTTAATGCGGGTCAGATACCTCAGTTA
TTATACAGACTTCCAACCAGTGATGGCAGTGCTTCAAAAGGCAAACAGCAAACCAGTGAACCTGTACACATTTTAAAGAGGTCTTTTGCA
AGAACTGTCTCAGTGGAATGTTTTGAGTCATTGTTGAGTATTCTTCACTGGAGCTGGACCACCTTAGTCTTAGGAGTTGAAGAACTTAGA
GGATTAAAAGGATTCCAGTTCACAGCTACACTCCTAGATTTAGAGAGACTGCGCTTTGTGGGTACCTGTTGTCTGAGGTTATTGCGTGTC
TATACCTGTGAAATTTACCCAGTGTCAGCTACAGGAAAAGCAGTTGTAGAAGAAACTAGCAAATTAGCAGAGTGTATTGGAAAAACCAGA
ACTTTGTTAAGAAAAATTTTATCAGAAGGAGTTGATCACTGCATGGTGAAATTGGATAATGATCCTCAAGGATATCTCAGTCAACCCTTG
AGTCTTCTAGAAGCTGTCCTTCAGGAATGTCATAATACTTTCACTGCCTGCTTTCATTCTTTCTACCCAACTCCTGCCTTACAGTGGGCT
TGCCTTTGTGATCTGCTGAATTGTTTGGATCAGGATATCCAAGAAGCAAACTTCAAGACATCAAGTAGCCGACTCCTTGCAGCTGTTATG
TCAGCTCTGTGTCACACGTCTGTTAAGCTGACTTCCATCTTCCCGATTGCGTATGATGGAGAAGTATTACTACGATCAATTGTTAAACAA
GTTAGTACAGAGAACGACTCAACACTAGTTCATCGTTTTCCCCTTTTGGTGGCACATATGGAAAAACTCAGCCAGAGTGAAGAGAATATC
TCAGGGATGACAAGCTTCCGTGAAGTTCTGGAGAAAATGCTGGTCATTGTTGTGCTACCAGTCAGGAACAGCCTGAGGAGAGAAAATGAA
CTCTTCTCCTCCCACCTCGTCTCTAACACCTGTGGATTACTGGCCAGCATTGTCAGTGAACTGACAGCGTCAGCCCTGGGATCTGAGGTT
GATGGACTTAATTCTCTTCACTCTGTAAAAGCTAGTGCTAACCGATTTACAAAAACAAGTCAGGGCAGAAGTTGGAACACTGGGAACGGG
TCCCCTGATGCAATCTGTTTTTCAGTAGACAAACCTGGAATAGTTGTGGTTGGTTTCTCTGTCTATGGAGGAGGTGGAATTCATGAATAT
GAATTAGAGGTGTTGGTTGATGATAGTGAACATGCAGGAGATTCAACTCATTCCCACAGATGGACATCTCTGGAATTAGTGAAAGGAACG
TACACAACGGATGACTCACCCAGTGATATAGCTGAGATCAGACTTGACAAAGTGGTTCCTTTAAAGGAAAATGTTAAATATGCTGTGCGC
TTGAGGAACTATGGAAGCCGTACAGCCAATGGAGATGGAGGAATGACCACAGTTCAGTGCCCTGATGGTGTGACATTCACATTCAGCACG
TGCAGCTTGAGCAGTAACGGCACAAACCAAACCAGAGGACAGATCCCACAGATACTCTACTATAGGAGTGAATTTGATGGAGATTTACAA
TCCCAACTTCTGAGTAAAGCCAATGAAGAAGATAAAAACTGTAGCAGAGCATTGTCTGTTGTAAGCACTGTCGTTCGAGCCTCTAAGGAC
CTCCTGCACAGAGCTCTTGCTGTGGATGCTGATGACATTCCAGAACTGCTGAGTTCTTCCAGTCTGTTTTCCATGCTGCTCCCCCTTATT
ATAGCCTACATAGGACCAGTAGCTGCTGCTATTCCCAAGGTGGCTGTAGAAGTCTTTGGCCTTGTCCAACAATTGCTTCCGTCAGTTGCC
ATTTTGAATCAGAAGTATGCACCGCCTGCCTTCAACCCTAATCAGTCGACAGATAGCACCACAGGAAACCAGCCTGAACAGGGCCTCTCT
GCTTGTACAACCTCCAGTCACTATGCTGTCATAGAGAGTGAGCACCCGTATAAACCTGCCTGTGTGATGCATTACAAGGTGACATTCCCA
GAATGTGTGAGGTGGATGACAATCGAATTTGACCCTCAGTGTGGTACTGCACAGTCAGAAGATGTCCTTCGTTTGTTGATTCCTGTCAGA
ACTGTTCAGAATTCAGGATATGGACCAAAATTGACATCTGTTCATGAAAATCTTAATTCATGGATAGAATTAAAGAAATTTTCAGGATCC
TCTGGGTGGCCTACTATGGTTTTGGTGTTGCCAGGAAATGAGGCCCTTTTTTCATTGGAGACTGCATCAGATTATGTGAAAGATGACAAA
GCTTCTTTCTATGGTTTTAAGTGTTTTGCAATTGGATATGAATTTAGCCCTGGACCTGATGAGGGAGTCATCCAATTGGAAAAAGAATTA
GCCAATCTTGGTGGGGTTTGTGCAGCAGCTCTGATGAAGAAGGACCTAGCACTTCCTATTGGTAATGAATTAGAAGAAGACCTTGAAATT
CTTGAGGAGGCTGCATTGCAGGTGTGCAAAACCCATTCTGGAATTCTTGGAAAGGGTCTAGCTCTTTCTCATTCACCAACTATATTAGAA
GCACTTGAGGGAAATTTACCACTCCAAATCCAAAGCAATGAACAGTCTTTTCTGGATGATTTTATTGCCTGTGTCCCAGGATCAAGTGGT
GGAAGGCTTGCAAGGTGGCTTCAGCCAGATTCATATGCGGATCCTCAGAAAACATCTTTGATCCTGAATAAGGATGATATTCGTTGTGGT
TGGCCTACCACCATAACTGTTCAAACAAAAGACCAGTATGGGGATGTGGTACATGTTCCCAATATGAAGGAATTGGCAGCAATGAAACAG
ATTCTCGTTAAGATGCATAGTAAACATTCTGAGAACAGCTTACTTCTCACTAAAACAGAACCAAAACATGTGACAGAAAATCAGAAATCA
AAGACTTTGAATGTGCCTAAAGAGCATGAAGACAATATATTTACACCTAAACCAACACTCTTTACTAAAAAAGAAGCACCTGAGTGGTCT
AAGAAACAAAAGATGAAGACCTAGTGTTTTGGATGGGAAGCACCTGTAGACCATTATATACTCCTGAAGTTCTTTTTCTGATGGAAAACA
AAATTCAGCTTAATCGTGTACTCAGCATTTTTTAAATAACAATGTTTATTTGAACTAATATTAAATTAACAAATTCAGTGTAATCAAAAT
GTGTAAAGAACAATCAATATACTTTATTTTTTTTTCTATTTTATAAAATAAATATATATGCTATGCTTTAAATTTTGGAGCTTTCATAAA
TGTTCAATGCATTTTAAGTGTGTGGCTTATAAATATTTTGGTATTTTTCTATACTACGTAAATTCTGAGTTTAAATGTCATACACAAATA
CTAAGACACTTTGCATTTTTAAAAATTAAGAATCATTTGTGAAGTCCACTACGAGGTACTTCAAAAGCCCAGTAATGGTGGTCAGATACC
ATGTAGATGGATACAGATTGTTGACTCTTTTGAAGTTGTTTTTTTCTTATATTTTATATTACCATTAACCAATAAAATCTGGCAGAAAGT

>In-frame_ENST00000544440_ENST00000326291_TCGA-QH-A6X9-01A_MYCBP2_chr13_77730193_-_PIBF1_chr13_73572960_length(amino acids)=2343AA_start in transcript=12_stop in transcript=7043
MFMPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRNKKILNKKKLKRKQKSKSKVKTRSK
SENLENTVIIPDIKLHSNPSAFNIYCNVRHCVLEWQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRF
SHPSLCLRSLQALLNVLQGQQPEGLQSEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALSCACLFSLVASWGETGRTLQAISAILTNN
GSHACQTIQVPTILNSLQRSVQAVLVGKIQIQDWFSNGIKKAALMHKWPLKEISVDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVR
GHIYNSTSRIRNRKEKKSWLGYAQGYLLYRDVNNHSMTAIRISPETLEQDGTVMLPDCHTEGQNILFTDGEYINQIAASRDDGFVVRIFA
TSTEPVLQQELQLKLARKCLHACGISLFDLEKDLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPI
TKSPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDA
IYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPP
GMHKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGESGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPV
PGVNIEEHLQLRQEEKRQRVIRRHRLEEGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRF
DCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGRP
ILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEALINSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFN
DSEQEDLQGFGVCLDPVYDVIWRFRPNTRELWCYNAVVADARLPSAADMQSRCSILSPELALPTGSRALTTRSHAALHILGCLDTLAAMQ
DLKMGVASTEEETQAVMKVYSKEDYSVVNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDG
DLLAETDVLAYDCAAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQIPQLLYRL
PTSDGSASKGKQQTSEPVHILKRSFARTVSVECFESLLSILHWSWTTLVLGVEELRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCE
IYPVSATGKAVVEETSKLAECIGKTRTLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAVLQECHNTFTACFHSFYPTPALQWACLCD
LLNCLDQDIQEANFKTSSSRLLAAVMSALCHTSVKLTSIFPIAYDGEVLLRSIVKQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMT
SFREVLEKMLVIVVLPVRNSLRRENELFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSLHSVKASANRFTKTSQGRSWNTGNGSPDA
ICFSVDKPGIVVVGFSVYGGGGIHEYELEVLVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNY
GSRTANGDGGMTTVQCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSKANEEDKNCSRALSVVSTVVRASKDLLHR
ALAVDADDIPELLSSSSLFSMLLPLIIAYIGPVAAAIPKVAVEVFGLVQQLLPSVAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTT
SSHYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQNSGYGPKLTSVHENLNSWIELKKFSGSSGWP
TMVLVLPGNEALFSLETASDYVKDDKASFYGFKCFAIGYEFSPGPDEGVIQLEKELANLGGVCAAALMKKDLALPIGNELEEDLEILEEA
ALQVCKTHSGILGKGLALSHSPTILEALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARWLQPDSYADPQKTSLILNKDDIRCGWPTT
ITVQTKDQYGDVVHVPNMKELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQK

--------------------------------------------------------------
>In-frame_ENST00000407578_ENST00000326291_TCGA-QH-A6X9-01A_MYCBP2_chr13_77730193_-_PIBF1_chr13_73572960_length(transcript)=7941nt_BP=7182nt
CGGCGGCAGTGGCGGCACCGCCTCCTCCTCACATTCCCGGGGTGGCGGGGTTAGATGAGCGGCCCCAGTAGCGGCGAGGGCGGCGCGGGG
GGGAGGAGGAGAAGAAGGAGGAGGAGAAGGAGGTCGCTGTCTTTGTAGTCTCCCTGCTGCGGGAGCCAGAGGCCGCCGCCGGAGCCGTCG
TCGTTGGAAAAGGGCTGTGTGTGCGCGCGCGTGTCTGCCCGCCCGGCCCGCGGGGACGAGGCGGCGGCGGCGGCGGCGGCGGCGAGGATG
ATGATGTGCGCAGCGACTGCCTCCCCCGCCGCCGCCTCCTCGGGGCTCGGCGGGGACGGATTCTACCCAGCCGCCACCTTCTCTTCCTCC
CCGGCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGG
GGTCACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGG
GGCGGCAGCGCTGGACACCCAGCCTCCAGGAATAAGAAAATTTTAAATAAGAAGAAATTGAAAAGAAAACAGAAGAGCAAATCAAAAGTG
AAGACAAGAAGCAAGTCTGAAAACTTAGAGAATACAGTAATCATACCAGATATCAAACTACATAGCAATCCTTCTGCTTTCAATATTTAC
TGTAATGTACGCCATTGCGTTCTGGAATGGCAGAAAAAGGAAATATCATTGGCAGCCGCATCTAAGAACTCTGTGCAGAGTGGAGAATCA
GATAGTGATGAAGAAGAGGAATCCAAAGAGCCCCCTATCAAGCTTCCAAAGATTATTGAGGTTGGCCTTTGTGAAGTTTTTGAATTGATC
AAAGAGACACGATTTTCTCATCCATCCCTGTGTCTCAGGAGTCTCCAAGCCCTGCTCAACGTGCTGCAGGGCCAGCAGCCAGAAGGCCTC
CAGTCTGAGCCACCTGAGGTCCTAGAGTCTCTCTTCCAGCTTCTTTTGGAAATCACCGTTCGAAGTACTGGGATGAATGACAGCACAGGA
CAGTCCTTAACAGCACTTTCCTGTGCTTGCCTCTTTAGTCTGGTGGCTTCTTGGGGAGAAACAGGAAGGACACTTCAGGCCATCTCTGCT
ATCCTCACCAACAATGGAAGCCATGCTTGCCAAACTATTCAGGTGCCAACAATTCTAAATTCGCTACAGAGAAGTGTACAAGCAGTTTTG
GTGGGAAAAATTCAAATTCAGGACTGGTTTAGTAATGGCATTAAGAAAGCAGCTTTAATGCACAAGTGGCCATTAAAAGAAATATCTGTT
GATGAAGATGACCAATGTCTACTTCAGAATGATGGATTTTTTCTTTATCTATTATGCAAGGATGGATTATATAAAATAGGCTCTGGATAC
AGTGGAACAGTTAGGGGCCATATATACAATTCTACATCCCGTATTAGAAACAGAAAAGAAAAAAAGTCTTGGTTAGGGTATGCTCAGGGT
TATTTATTATATAGAGATGTGAATAACCACAGCATGACAGCCATAAGGATAAGCCCTGAAACACTGGAGCAAGATGGTACTGTGATGTTA
CCAGATTGCCACACTGAAGGTCAAAATATTTTATTCACTGATGGAGAATATATTAATCAGATAGCTGCTTCAAGAGATGATGGCTTTGTT
GTCAGAATATTTGCCACAAGCACTGAACCTGTTCTACAGCAAGAATTGCAACTTAAACTGGCTAGAAAATGCTTACATGCCTGTGGTATC
TCACTATTCGATCTGGAAAAGGACTTGCATATTATAAGTACAGGATTTGATGAGGAGTCAGCAATTCTTGGTGCAGGACGAGAGTTTGCG
CTAATGAAAACAGCAAATGGAAAGATATATTACACTGGCAAATACCAGAGTCTTGGAATCAAACAAGGTGGTCCTTCAGCAGGAAAATGG
GTTGAGCTACCAATTACAAAATCTCCAAAGATAGTACACTTCTCAGTTGGACACGATGGCTCTCACGCCCTTTTAGTTGCAGAAGATGGG
AGCATATTCTTTACAGGATCTGCTAGTAAAGGAGAAGATGGAGAATCAACTAAGAGCAGACGGCAATCCAAACCTTATAAACCTAAAAAG
ATAATTAAGATGGAAGGAAAGATTGTGGTATATACAGCCTGCAATAATGGAAGTAGTTCTGTTATTTCTAAAGATGGAGAACTCTACATG
TTTGGAAAAGATGCCATTTACTCTGATAGTTCAAGTTTGGTAACTGATTTGAAGGGCCATTTTGTAACTCAGGTAGCTATGGGCAAAGCT
CACACTTGTGTTTTAATGAAGAATGGAGAGGTGTGGACATTTGGTGTAAATAATAAAGGACAGTGTGGACGAGATACTGGTGCCATGAAC
CAAGGTGGGAAAGGGTTTGGAGTTGAAAATATGGCAACAGCAATGGATGAAGACCTGGAAGAAGAACTAGATGAAAAAGATGAGAAGTCT
ATGATGTGCCCTCCAGGCATGCACAAATGGAAGCTGGAGCAGTGCATGGTTTGCACTGTCTGTGGAGACTGTACAGGTTATGGAGCCAGC
TGTGTCAGTAGTGGACGGCCAGACAGAGTCCCCGGAGGGATCTGTGGTTGTGGTTCCGGAGAATCTGGTTGTGCTGTGTGTGGATGTTGC
AAGGCCTGTGCAAGAGAGTTAGATGGTCAAGAGGCAAGACAAAGAGGAATTCTTGATGCAGTGAAAGAAATGATACCTTTAGATCTTCTT
TTAGCTGTCCCAGTGCCCGGGGTTAACATTGAAGAACACCTTCAGTTACGACAAGAAGAAAAACGGCAACGTGTAATCAGAAGGCACAGA
TTAGAGGAAGGAAGAGGCCCCCTTGTATTTGCTGGTCCTATTTTTATGAACCATCGAGAACAGGCTCTAGCCAGACTCAGATCCCATCCA
GCACAGCTAAAGCATAAACGGGACAAGCACAAAGATGGAAGTGGAGAAAGAGGCGAAAAGGATGCAAGCAAAATCACAACATACCCTCCA
GGCTCTGTGCGATTTGACTGTGAGCTCCGGGCAGTCCAAGTCAGCTGTGGATTTCACCATTCAGTGGTTTTAATGGAAAATGGAGATGTC
TATACATTTGGTTATGGGCAGCATGGGCAGCTAGGACATGGAGATGTCAACTCCAGGGGATGTCCCACTCTTGTTCAAGCATTGCCAGGC
CCTAGCACACAAGTCACTGCAGGCAGCAACCATACGGCAGTACTTTTAATGGATGGACAGGTCTTCACATTTGGAAGTTTTTCTAAAGGA
CAACTGGGCAGACCAATTTTGGATGTGCCATATTGGAATGCAAAGCCAGCTCCCATGCCTAACATTGGATCAAAATATGGAAGAAAAGCT
ACTTGGATAGGTGCAAGTGGGGACCAAACTTTTTTACGAATTGATGAAGCACTTATTAATTCTCATGTACTTGCTACATCAGAAATTTTT
GCCAGTAAACACATAATAGGCTTGGTACCTGCTTCTATATCAGAACCTCCTCCATTTAAATGCCTTCTGATAAATAAAGTGGATGGGAGT
TGTAAAACTTTTAATGACTCAGAACAAGAGGATCTGCAAGGATTTGGTGTGTGTCTTGATCCTGTATATGATGTAATTTGGAGGTTTCGA
CCAAATACTAGAGAGCTGTGGTGTTACAATGCGGTGGTTGCTGATGCCAGGCTTCCCTCTGCAGCAGACATGCAGTCCAGATGTAGTATC
CTAAGTCCTGAACTTGCCTTACCAACAGGATCAAGGGCCCTCACTACCCGATCTCATGCAGCTTTGCACATTTTAGGTTGTCTTGATACC
TTGGCAGCTATGCAGGACTTAAAAATGGGTGTTGCAAGTACAGAGGAAGAGACTCAAGCAGTAATGAAGGTTTATTCTAAAGAAGATTAT
AGTGTGGTAAACAGGTTTGAAAGTCATGGAGGAGGCTGGGGTTATTCTGCCCATTCAGTAGAAGCTATACGTTTCAGTGCCGACACTGAT
ATTTTACTTGGTGGTCTTGGTCTGTTTGGAGGTAGAGGAGAATATACTGCTAAAATTAAGCTGTTTGAATTGGGTCCTGATGGAGGAGAT
CATGAAACTGATGGTGACCTTCTTGCAGAGACTGATGTATTGGCTTATGACTGTGCTGCTAGAGAAAAATATGCAATGATGTTTGATGAG
CCTGTTCTCCTGCAAGCTGGGTGGTGGTATGTGGCATGGGCCCGAGTGTCAGGACCCAGCAGTGACTGTGGATCTCATGGACAGGCATCT
ATTACCACAGATGATGGGGTTGTTTTCCAGTTCAAGAGTTCAAAGAAATCAAATAATGGTACAGATGTTAATGCGGGTCAGATACCTCAG
TTATTATACAGACTTCCAACCAGTGATGGCAGTGCTTCAAAAGGCAAACAGCAAACCAGTGAACCTGTACACATTTTAAAGAGGTCTTTT
GCAAGAACTGTCTCAGTGGAATGTTTTGAGTCATTGTTGAGTATTCTTCACTGGAGCTGGACCACCTTAGTCTTAGGAGTTGAAGAACTT
AGAGGATTAAAAGGATTCCAGTTCACAGCTACACTCCTAGATTTAGAGAGACTGCGCTTTGTGGGTACCTGTTGTCTGAGGTTATTGCGT
GTCTATACCTGTGAAATTTACCCAGTGTCAGCTACAGGAAAAGCAGTTGTAGAAGAAACTAGCAAATTAGCAGAGTGTATTGGAAAAACC
AGAACTTTGTTAAGAAAAATTTTATCAGAAGGAGTTGATCACTGCATGGTGAAATTGGATAATGATCCTCAAGGATATCTCAGTCAACCC
TTGAGTCTTCTAGAAGCTGTCCTTCAGGAATGTCATAATACTTTCACTGCCTGCTTTCATTCTTTCTACCCAACTCCTGCCTTACAGTGG
GCTTGCCTTTGTGATCTGCTGAATTGTTTGGATCAGGATATCCAAGAAGCAAACTTCAAGACATCAAGTAGCCGACTCCTTGCAGCTGTT
ATGTCAGCTCTGTGTCACACGTCTGTTAAGCTGACTTCCATCTTCCCGATTGCGTATGATGGAGAAGTATTACTACGATCAATTGTTAAA
CAAGTTAGTACAGAGAACGACTCAACACTAGTTCATCGTTTTCCCCTTTTGGTGGCACATATGGAAAAACTCAGCCAGAGTGAAGAGAAT
ATCTCAGGGATGACAAGCTTCCGTGAAGTTCTGGAGAAAATGCTGGTCATTGTTGTGCTACCAGTCAGGAACAGCCTGAGGAGAGAAAAT
GAACTCTTCTCCTCCCACCTCGTCTCTAACACCTGTGGATTACTGGCCAGCATTGTCAGTGAACTGACAGCGTCAGCCCTGGGATCTGAG
GTTGATGGACTTAATTCTCTTCACTCTGTAAAAGCTAGTGCTAACCGATTTACAAAAACAAGTCAGGGCAGAAGTTGGAACACTGGGAAC
GGGTCCCCTGATGCAATCTGTTTTTCAGTAGACAAACCTGGAATAGTTGTGGTTGGTTTCTCTGTCTATGGAGGAGGTGGAATTCATGAA
TATGAATTAGAGGTGTTGGTTGATGATAGTGAACATGCAGGAGATTCAACTCATTCCCACAGATGGACATCTCTGGAATTAGTGAAAGGA
ACGTACACAACGGATGACTCACCCAGTGATATAGCTGAGATCAGACTTGACAAAGTGGTTCCTTTAAAGGAAAATGTTAAATATGCTGTG
CGCTTGAGGAACTATGGAAGCCGTACAGCCAATGGAGATGGAGGAATGACCACAGTTCAGTGCCCTGATGGTGTGACATTCACATTCAGC
ACGTGCAGCTTGAGCAGTAACGGCACAAACCAAACCAGAGGACAGATCCCACAGATACTCTACTATAGGAGTGAATTTGATGGAGATTTA
CAATCCCAACTTCTGAGTAAAGCCAATGAAGAAGATAAAAACTGTAGCAGAGCATTGTCTGTTGTAAGCACTGTCGTTCGAGCCTCTAAG
GACCTCCTGCACAGAGCTCTTGCTGTGGATGCTGATGACATTCCAGAACTGCTGAGTTCTTCCAGTCTGTTTTCCATGCTGCTCCCCCTT
ATTATAGCCTACATAGGACCAGTAGCTGCTGCTATTCCCAAGGTGGCTGTAGAAGTCTTTGGCCTTGTCCAACAATTGCTTCCGTCAGTT
GCCATTTTGAATCAGAAGTATGCACCGCCTGCCTTCAACCCTAATCAGTCGACAGATAGCACCACAGGAAACCAGCCTGAACAGGGCCTC
TCTGCTTGTACAACCTCCAGTCACTATGCTGTCATAGAGAGTGAGCACCCGTATAAACCTGCCTGTGTGATGCATTACAAGGTGACATTC
CCAGAATGTGTGAGGTGGATGACAATCGAATTTGACCCTCAGTGTGGTACTGCACAGTCAGAAGATGTCCTTCGTTTGTTGATTCCTGTC
AGAACTGTTCAGAATTCAGGATATGGACCAAAATTGACATCTGTTCATGAAAATCTTAATTCATGGATAGAATTAAAGAAATTTTCAGGA
TCCTCTGGGTGGCCTACTATGGTTTTGGTGTTGCCAGGAAATGAGGCCCTTTTTTCATTGGAGACTGCATCAGATTATGTGAAAGATGAC
AAAGCTTCTTTCTATGGTTTTAAGTGTTTTGCAATTGGATATGAATTTAGCCCTGGACCTGATGAGGGAGTCATCCAATTGGAAAAAGAA
TTAGCCAATCTTGGTGGGGTTTGTGCAGCAGCTCTGATGAAGAAGGACCTAGCACTTCCTATTGGTAATGAATTAGAAGAAGACCTTGAA
ATTCTTGAGGAGGCTGCATTGCAGGTGTGCAAAACCCATTCTGGAATTCTTGGAAAGGGTCTAGCTCTTTCTCATTCACCAACTATATTA
GAAGCACTTGAGGGAAATTTACCACTCCAAATCCAAAGCAATGAACAGTCTTTTCTGGATGATTTTATTGCCTGTGTCCCAGGATCAAGT
GGTGGAAGGCTTGCAAGGTGGCTTCAGCCAGATTCATATGCGGATCCTCAGAAAACATCTTTGATCCTGAATAAGGATGATATTCGTTGT
GGTTGGCCTACCACCATAACTGTTCAAACAAAAGACCAGTATGGGGATGTGGTACATGTTCCCAATATGAAGGAATTGGCAGCAATGAAA
CAGATTCTCGTTAAGATGCATAGTAAACATTCTGAGAACAGCTTACTTCTCACTAAAACAGAACCAAAACATGTGACAGAAAATCAGAAA
TCAAAGACTTTGAATGTGCCTAAAGAGCATGAAGACAATATATTTACACCTAAACCAACACTCTTTACTAAAAAAGAAGCACCTGAGTGG
TCTAAGAAACAAAAGATGAAGACCTAGTGTTTTGGATGGGAAGCACCTGTAGACCATTATATACTCCTGAAGTTCTTTTTCTGATGGAAA
ACAAAATTCAGCTTAATCGTGTACTCAGCATTTTTTAAATAACAATGTTTATTTGAACTAATATTAAATTAACAAATTCAGTGTAATCAA
AATGTGTAAAGAACAATCAATATACTTTATTTTTTTTTCTATTTTATAAAATAAATATATATGCTATGCTTTAAATTTTGGAGCTTTCAT
AAATGTTCAATGCATTTTAAGTGTGTGGCTTATAAATATTTTGGTATTTTTCTATACTACGTAAATTCTGAGTTTAAATGTCATACACAA
ATACTAAGACACTTTGCATTTTTAAAAATTAAGAATCATTTGTGAAGTCCACTACGAGGTACTTCAAAAGCCCAGTAATGGTGGTCAGAT
ACCATGTAGATGGATACAGATTGTTGACTCTTTTGAAGTTGTTTTTTTCTTATATTTTATATTACCATTAACCAATAAAATCTGGCAGAA

>In-frame_ENST00000407578_ENST00000326291_TCGA-QH-A6X9-01A_MYCBP2_chr13_77730193_-_PIBF1_chr13_73572960_length(amino acids)=2407AA_start in transcript=183_stop in transcript=7406
MEKGCVCARVSARPARGDEAAAAAAAARMMMCAATASPAAASSGLGGDGFYPAATFSSSPAPGALFMPVPDGSVAAAGLGLGLPAADSRG
HYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRNKKILNKKKLKRKQKSKSKVKTRSKSENLENTVIIPDIKLHSNPSAFNIYC
NVRHCVLEWQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRFSHPSLCLRSLQALLNVLQGQQPEGLQ
SEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALSCACLFSLVASWGETGRTLQAISAILTNNGSHACQTIQVPTILNSLQRSVQAVLV
GKIQIQDWFSNGIKKAALMHKWPLKEISVDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGHIYNSTSRIRNRKEKKSWLGYAQGY
LLYRDVNNHSMTAIRISPETLEQDGTVMLPDCHTEGQNILFTDGEYINQIAASRDDGFVVRIFATSTEPVLQQELQLKLARKCLHACGIS
LFDLEKDLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDGSHALLVAEDGS
IFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAH
TCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGASC
VSSGRPDRVPGGICGCGSGESGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPGVNIEEHLQLRQEEKRQRVIRRHRL
EEGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVY
TFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKAT
WIGASGDQTFLRIDEALINSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFNDSEQEDLQGFGVCLDPVYDVIWRFRP
NTRELWCYNAVVADARLPSAADMQSRCSILSPELALPTGSRALTTRSHAALHILGCLDTLAAMQDLKMGVASTEEETQAVMKVYSKEDYS
VVNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFDEP
VLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQIPQLLYRLPTSDGSASKGKQQTSEPVHILKRSFA
RTVSVECFESLLSILHWSWTTLVLGVEELRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCEIYPVSATGKAVVEETSKLAECIGKTR
TLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAVLQECHNTFTACFHSFYPTPALQWACLCDLLNCLDQDIQEANFKTSSSRLLAAVM
SALCHTSVKLTSIFPIAYDGEVLLRSIVKQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMTSFREVLEKMLVIVVLPVRNSLRRENE
LFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSLHSVKASANRFTKTSQGRSWNTGNGSPDAICFSVDKPGIVVVGFSVYGGGGIHEY
ELEVLVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGSRTANGDGGMTTVQCPDGVTFTFST
CSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSKANEEDKNCSRALSVVSTVVRASKDLLHRALAVDADDIPELLSSSSLFSMLLPLI
IAYIGPVAAAIPKVAVEVFGLVQQLLPSVAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTTSSHYAVIESEHPYKPACVMHYKVTFP
ECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQNSGYGPKLTSVHENLNSWIELKKFSGSSGWPTMVLVLPGNEALFSLETASDYVKDDK
ASFYGFKCFAIGYEFSPGPDEGVIQLEKELANLGGVCAAALMKKDLALPIGNELEEDLEILEEAALQVCKTHSGILGKGLALSHSPTILE
ALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARWLQPDSYADPQKTSLILNKDDIRCGWPTTITVQTKDQYGDVVHVPNMKELAAMKQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MYCBP2-PIBF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MYCBP2-PIBF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MYCBP2-PIBF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePIBF1C4540389JOUBERT SYNDROME 332GENOMICS_ENGLAND;UNIPROT
TgenePIBF1C0000821Threatened abortion1CTD_human
TgenePIBF1C0004134Ataxia1GENOMICS_ENGLAND
TgenePIBF1C0424605Developmental delay (disorder)1GENOMICS_ENGLAND
TgenePIBF1C0431399Familial aplasia of the vermis1GENOMICS_ENGLAND;ORPHANET
TgenePIBF1C0557874Global developmental delay1GENOMICS_ENGLAND
TgenePIBF1C4313693Vermis hypoplasia1GENOMICS_ENGLAND
TgenePIBF1C4551568Joubert syndrome 11ORPHANET