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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYCBP2-TAF6L (FusionGDB2 ID:55906)

Fusion Gene Summary for MYCBP2-TAF6L

check button Fusion gene summary
Fusion gene informationFusion gene name: MYCBP2-TAF6L
Fusion gene ID: 55906
HgeneTgene
Gene symbol

MYCBP2

TAF6L

Gene ID

23077

10629

Gene nameMYC binding protein 2TATA-box binding protein associated factor 6 like
SynonymsMyc-bp2|PAM|PHR1|PhrPAF65A
Cytomap

13q22.3

11q12.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MYCBP2HighwireMYC binding protein 2, E3 ubiquitin protein ligasePAM/Highwire/RPM-1 protein 1RING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with MycTAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6LPAF65-alphaPCAF-associated factor 65-alphaTAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDap300/CBP-associated factor (PCAF
Modification date2020031320200313
UniProtAcc

O75592

.
Ensembl transtripts involved in fusion geneENST00000544440, ENST00000407578, 
ENST00000357337, ENST00000360084, 
ENST00000482517, 		ENST00000294168, 
Fusion gene scores* DoF score14 X 16 X 8=17924 X 4 X 4=64
# samples 154
** MAII scorelog2(15/1792*10)=-3.57853623156172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYCBP2 [Title/Abstract] AND TAF6L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYCBP2(77900609)-TAF6L(62549585), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYCBP2

GO:0016567

protein ubiquitination

29643511

HgeneMYCBP2

GO:0031398

positive regulation of protein ubiquitination

20534529

TgeneTAF6L

GO:0043966

histone H3 acetylation

11564863


check buttonFusion gene breakpoints across MYCBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TAF6L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-ZG-A9LZ-01AMYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
ChimerDB4PRADTCGA-ZG-A9LZ-01AMYCBP2chr13

77900609

-TAF6Lchr11

62549585

+


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Fusion Gene ORF analysis for MYCBP2-TAF6L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000544440ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
In-frameENST00000407578ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
In-frameENST00000357337ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
5UTR-3CDSENST00000360084ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+
intron-3CDSENST00000482517ENST00000294168MYCBP2chr13

77900609

-TAF6Lchr11

62549585

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544440MYCBP2chr1377900609-ENST00000294168TAF6Lchr1162549585+15152062271468413
ENST00000407578MYCBP2chr1377900609-ENST00000294168TAF6Lchr1162549585+18785695901831413
ENST00000357337MYCBP2chr1377900609-ENST00000294168TAF6Lchr1162549585+15902813021543413

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544440ENST00000294168MYCBP2chr1377900609-TAF6Lchr1162549585+0.36875490.6312451
ENST00000407578ENST00000294168MYCBP2chr1377900609-TAF6Lchr1162549585+0.246745020.753255
ENST00000357337ENST00000294168MYCBP2chr1377900609-TAF6Lchr1162549585+0.294241580.70575845

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Fusion Genomic Features for MYCBP2-TAF6L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYCBP2-TAF6L


check button Go to

FGviewer for the breakpoints of chr13:77900609-chr11:62549585

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYCBP2

O75592

.
FUNCTION: Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (By similarity). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity). Regulates axon guidance in the olfactory system (By similarity). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (By similarity). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (PubMed:29643511). Regulates the internalization of TRPV1 in peripheral sensory neurons (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (PubMed:18308511, PubMed:27278822). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (PubMed:9689053). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). {ECO:0000250|UniProtKB:Q7TPH6, ECO:0000269|PubMed:18308511, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26304119, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:29643511, ECO:0000269|PubMed:9689053}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284103_12662.6666666666666644641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2842720_284462.6666666666666644641.0Compositional biasSer-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2843194_321562.6666666666666644641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2843262_329362.6666666666666644641.0Compositional biasNote=Gly-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284766_81462.6666666666666644641.0Compositional biasCys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183103_12662.6666666666666644641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1832720_284462.6666666666666644641.0Compositional biasSer-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1833194_321562.6666666666666644641.0Compositional biasLys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1833262_329362.6666666666666644641.0Compositional biasNote=Gly-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183766_81462.6666666666666644641.0Compositional biasCys-rich
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2843719_389762.6666666666666644641.0DomainDOC
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1833719_389762.6666666666666644641.0DomainDOC
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2841235_138662.6666666666666644641.0RegionPHR domain 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2841726_188462.6666666666666644641.0RegionPHR domain 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2842022_255062.6666666666666644641.0RegionRAE1 binding
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2844539_467662.6666666666666644641.0RegionTandem cysteine domain
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1831235_138662.6666666666666644641.0RegionPHR domain 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1831726_188462.6666666666666644641.0RegionPHR domain 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1832022_255062.6666666666666644641.0RegionRAE1 binding
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1834539_467662.6666666666666644641.0RegionTandem cysteine domain
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2841010_106662.6666666666666644641.0RepeatRCC1 5
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2842341_244362.6666666666666644641.0RepeatFilamin
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284600_65562.6666666666666644641.0RepeatRCC1 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284699_75562.6666666666666644641.0RepeatRCC1 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284907_95762.6666666666666644641.0RepeatRCC1 3
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-284958_100862.6666666666666644641.0RepeatRCC1 4
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1831010_106662.6666666666666644641.0RepeatRCC1 5
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1832341_244362.6666666666666644641.0RepeatFilamin
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183600_65562.6666666666666644641.0RepeatRCC1 1
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183699_75562.6666666666666644641.0RepeatRCC1 2
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183907_95762.6666666666666644641.0RepeatRCC1 3
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-183958_100862.6666666666666644641.0RepeatRCC1 4
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000357337-2844428_447962.6666666666666644641.0Zinc fingerRING-type%3B atypical
HgeneMYCBP2chr13:77900609chr11:62549585ENST00000544440-1834428_447962.6666666666666644641.0Zinc fingerRING-type%3B atypical


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Fusion Gene Sequence for MYCBP2-TAF6L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000544440_ENST00000294168_TCGA-ZG-A9LZ-01A_MYCBP2_chr13_77900609_-_TAF6L_chr11_62549585_length(transcript)=1515nt_BP=206nt
GCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGT
CACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGC
GGCAGCGCTGGACACCCAGCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGAGCCTAT
TTCGTAATCCGCACCTGTGCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTGCCTCCA
TCAACCCCCTGAATGACCACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTGTAAGTG
GCCTCTATCAGCATATCCTGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGGTGGGGC
TGCATGCTCTTGGCTGGAAGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGGATGATT
ATTCAGTATCTAATGCCCAGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGATGAAGG
CCCAGGCAGCAGAGCCCAACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCTTTCAAG
AGTCGTCCTCCGGGGGCGGTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTTCTCTTT
CGGTGACCCTGGCCGACATCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTGCACCCA
CGGCTCCGCGGCCGCCCGGGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCGCCATAG
TCAGCCCGCACGGCGACGAGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCAGGCCCT
TGCCGCGCGTGCATCGGGCGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTTTCGCCC
CGCGCGGCGCCCCGCACTTTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCTTCCCCG
CGCCGTACGGGCCTAGCCCGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGGCGCTCT

>In-frame_ENST00000544440_ENST00000294168_TCGA-ZG-A9LZ-01A_MYCBP2_chr13_77900609_-_TAF6L_chr11_62549585_length(amino acids)=413AA_start in transcript=227_stop in transcript=1468
MEQLHRLLQVARSLFRNPHLCLGPYVRCLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILAD
PVRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPNRGGPGGRGC
RRLDDLPWDSLLFQESSSGGGAEPSFGSGLPLPPGGAGPEDPSLSVTLADIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAP
DSVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRPLPRVHRARGAPRQQGPGTGTRDVFQKSRFAPRGAPHFRFIIAGRQA

--------------------------------------------------------------
>In-frame_ENST00000407578_ENST00000294168_TCGA-ZG-A9LZ-01A_MYCBP2_chr13_77900609_-_TAF6L_chr11_62549585_length(transcript)=1878nt_BP=569nt
CGGCGGCAGTGGCGGCACCGCCTCCTCCTCACATTCCCGGGGTGGCGGGGTTAGATGAGCGGCCCCAGTAGCGGCGAGGGCGGCGCGGGG
GGGAGGAGGAGAAGAAGGAGGAGGAGAAGGAGGTCGCTGTCTTTGTAGTCTCCCTGCTGCGGGAGCCAGAGGCCGCCGCCGGAGCCGTCG
TCGTTGGAAAAGGGCTGTGTGTGCGCGCGCGTGTCTGCCCGCCCGGCCCGCGGGGACGAGGCGGCGGCGGCGGCGGCGGCGGCGAGGATG
ATGATGTGCGCAGCGACTGCCTCCCCCGCCGCCGCCTCCTCGGGGCTCGGCGGGGACGGATTCTACCCAGCCGCCACCTTCTCTTCCTCC
CCGGCGCCGGGGGCGCTGTTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGG
GGTCACTACCAGCTGCTGCTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGG
GGCGGCAGCGCTGGACACCCAGCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGAGCC
TATTTCGTAATCCGCACCTGTGCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTGCCT
CCATCAACCCCCTGAATGACCACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTGTAA
GTGGCCTCTATCAGCATATCCTGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGGTGG
GGCTGCATGCTCTTGGCTGGAAGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGGATG
ATTATTCAGTATCTAATGCCCAGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGATGA
AGGCCCAGGCAGCAGAGCCCAACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCTTTC
AAGAGTCGTCCTCCGGGGGCGGTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTTCTC
TTTCGGTGACCCTGGCCGACATCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTGCAC
CCACGGCTCCGCGGCCGCCCGGGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCGCCA
TAGTCAGCCCGCACGGCGACGAGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCAGGC
CCTTGCCGCGCGTGCATCGGGCGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTTTCG
CCCCGCGCGGCGCCCCGCACTTTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCTTCC
CCGCGCCGTACGGGCCTAGCCCGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGGCGC

>In-frame_ENST00000407578_ENST00000294168_TCGA-ZG-A9LZ-01A_MYCBP2_chr13_77900609_-_TAF6L_chr11_62549585_length(amino acids)=413AA_start in transcript=590_stop in transcript=1831
MEQLHRLLQVARSLFRNPHLCLGPYVRCLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILAD
PVRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPNRGGPGGRGC
RRLDDLPWDSLLFQESSSGGGAEPSFGSGLPLPPGGAGPEDPSLSVTLADIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAP
DSVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRPLPRVHRARGAPRQQGPGTGTRDVFQKSRFAPRGAPHFRFIIAGRQA

--------------------------------------------------------------
>In-frame_ENST00000357337_ENST00000294168_TCGA-ZG-A9LZ-01A_MYCBP2_chr13_77900609_-_TAF6L_chr11_62549585_length(transcript)=1590nt_BP=281nt
GGCGGCGGCAGTGGCGGCACCGCCTCCTCCTCACATTCCCGGGGTGGCGGGGTTAGATGAGCGGCCCCAGTAGCGGCGCCGGGGGCGCTG
TTCATGCCGGTTCCCGACGGCTCCGTGGCTGCTGCGGGGCTGGGGCTGGGGCTACCCGCCGCGGACTCCCGGGGTCACTACCAGCTGCTG
CTGTCAGGCCGGGCCCTGGCCGACCGCTACCGGAGGATTTATACCGCTGCGCTCAATGACAGGGACCAGGGGGGCGGCAGCGCTGGACAC
CCAGCCTCCAGGTGAAATCTGTAAGCCATGACCTGGAGCAACTGCACCGGCTGCTGCAGGTGGCACGGAGCCTATTTCGTAATCCGCACC
TGTGCTTGGGGCCCTATGTCCGCTGTCTGGTGGGCAGTGTCCTCTACTGTGTCCTGGAGCCACTGGCTGCCTCCATCAACCCCCTGAATG
ACCACTGGACTCTGCGGGATGGGGCTGCCCTCCTGCTCAGCCACATCTTCTGGACTCATGGGGACCTTGTAAGTGGCCTCTATCAGCATA
TCCTGCTATCCCTGCAGAAGATCCTGGCAGATCCTGTGCGGCCGCTCTGCTGCCACTATGGAGCCGTGGTGGGGCTGCATGCTCTTGGCT
GGAAGGCAGTAGAACGAGTCCTGTACCCACACCTGTCCACCTACTGGACAAACTTGCAGGCTGTGCTGGATGATTATTCAGTATCTAATG
CCCAGGTCAAAGCAGATGGACACAAAGTCTATGGAGCCATTCTGGTGGCGGTAGAGCGACTGCTGAAGATGAAGGCCCAGGCAGCAGAGC
CCAACAGGGGTGGCCCAGGTGGCAGGGGGTGCCGGCGCCTGGACGACCTGCCATGGGACAGCCTTCTCTTTCAAGAGTCGTCCTCCGGGG
GCGGTGCAGAACCCAGCTTTGGGTCCGGCCTCCCGCTGCCGCCAGGGGGCGCGGGGCCGGAGGACCCTTCTCTTTCGGTGACCCTGGCCG
ACATCTACCGGGAGCTCTACGCCTTCTTCGGTGACAGCTTGGCCACACGCTTTGGCACCGGCCAGCCTGCACCCACGGCTCCGCGGCCGC
CCGGGGACAAGAAGGAGCCGGCGGCAGCCCCGGACTCGGTGCGGAAGATGCCGCAGCTGACGGCAAGCGCCATAGTCAGCCCGCACGGCG
ACGAGAGCCCCCGGGGCAGCGGCGGAGGCGGCCCCGCGTCGGCCTCTGGGCCCGCCGCCTCTGAGAGCAGGCCCTTGCCGCGCGTGCATC
GGGCGCGCGGGGCACCCCGGCAGCAGGGCCCCGGGACCGGCACCCGCGACGTTTTCCAGAAGAGCCGTTTCGCCCCGCGCGGCGCCCCGC
ACTTTCGTTTCATCATAGCCGGGCGGCAGGCTGGGAGGCGCTGCCGCGGGCGCCTTTTCCAGACTGCCTTCCCCGCGCCGTACGGGCCTA
GCCCGGCCTCGCGCTACGTGCAGAAACTGCCCATGATCGGCCGTACCAGCCGCCCCGCCCGCCGGTGGGCGCTCTCGGACTACTCGCTGT

>In-frame_ENST00000357337_ENST00000294168_TCGA-ZG-A9LZ-01A_MYCBP2_chr13_77900609_-_TAF6L_chr11_62549585_length(amino acids)=413AA_start in transcript=302_stop in transcript=1543
MEQLHRLLQVARSLFRNPHLCLGPYVRCLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILAD
PVRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPNRGGPGGRGC
RRLDDLPWDSLLFQESSSGGGAEPSFGSGLPLPPGGAGPEDPSLSVTLADIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAP
DSVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRPLPRVHRARGAPRQQGPGTGTRDVFQKSRFAPRGAPHFRFIIAGRQA

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Fusion Gene PPI Analysis for MYCBP2-TAF6L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYCBP2-TAF6L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYCBP2-TAF6L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource