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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYD88-MYLK (FusionGDB2 ID:55913)

Fusion Gene Summary for MYD88-MYLK

check button Fusion gene summary
Fusion gene informationFusion gene name: MYD88-MYLK
Fusion gene ID: 55913
HgeneTgene
Gene symbol

MYD88

MYLK

Gene ID

4615

4638

Gene nameMYD88 innate immune signal transduction adaptormyosin light chain kinase
SynonymsMYD88DAAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MSTP083|MYLK1|smMLCK
Cytomap

3p22.2

3q21.1

Type of geneprotein-codingprotein-coding
Descriptionmyeloid differentiation primary response protein MyD88mutant myeloid differentiation primary response 88myeloid differentiation primary response 88myeloid differentiation primary response gene (88)myosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin
Modification date2020032720200320
UniProtAcc.

Q86YV6

Ensembl transtripts involved in fusion geneENST00000417037, ENST00000396334, 
ENST00000424893, ENST00000495303, 
ENST00000443433, ENST00000481122, 
ENST00000360772, ENST00000359169, 
ENST00000360304, ENST00000418370, 
ENST00000578202, ENST00000354792, 
ENST00000346322, ENST00000583087, 
ENST00000475616, ENST00000510775, 
Fusion gene scores* DoF score5 X 5 X 2=5014 X 15 X 4=840
# samples 515
** MAII scorelog2(5/50*10)=0log2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYD88 [Title/Abstract] AND MYLK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYD88(38181436)-MYLK(123383107), # samples:2
Anticipated loss of major functional domain due to fusion event.MYD88-MYLK seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MYD88-MYLK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
MYD88-MYLK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYD88

GO:0070935

3'-UTR-mediated mRNA stabilization

15294994

TgeneMYLK

GO:0030335

positive regulation of cell migration

19826488

TgeneMYLK

GO:0051928

positive regulation of calcium ion transport

16284075

TgeneMYLK

GO:0071476

cellular hypotonic response

11976941

TgeneMYLK

GO:0090303

positive regulation of wound healing

15825080


check buttonFusion gene breakpoints across MYD88 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MYLK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABP285827MYD88chr3

38181436

+MYLKchr3

123383107

-
ChiTaRS5.0N/ABP285886MYD88chr3

38181436

+MYLKchr3

123383107

-


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Fusion Gene ORF analysis for MYD88-MYLK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000417037ENST00000360772MYD88chr3

38181436

+MYLKchr3

123383107

-
Frame-shiftENST00000417037ENST00000359169MYD88chr3

38181436

+MYLKchr3

123383107

-
Frame-shiftENST00000417037ENST00000360304MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000417037ENST00000418370MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000417037ENST00000578202MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000417037ENST00000354792MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000417037ENST00000346322MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000417037ENST00000583087MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000417037ENST00000475616MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000417037ENST00000510775MYD88chr3

38181436

+MYLKchr3

123383107

-
Frame-shiftENST00000396334ENST00000360772MYD88chr3

38181436

+MYLKchr3

123383107

-
Frame-shiftENST00000396334ENST00000359169MYD88chr3

38181436

+MYLKchr3

123383107

-
Frame-shiftENST00000396334ENST00000360304MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000396334ENST00000418370MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000396334ENST00000578202MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000396334ENST00000354792MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000396334ENST00000346322MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000396334ENST00000583087MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000396334ENST00000475616MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000396334ENST00000510775MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-3CDSENST00000424893ENST00000360772MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-3CDSENST00000424893ENST00000359169MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-3CDSENST00000424893ENST00000360304MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000424893ENST00000418370MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000424893ENST00000578202MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000424893ENST00000354792MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000424893ENST00000346322MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000424893ENST00000583087MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000424893ENST00000475616MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000424893ENST00000510775MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-3CDSENST00000495303ENST00000360772MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-3CDSENST00000495303ENST00000359169MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-3CDSENST00000495303ENST00000360304MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000495303ENST00000418370MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000495303ENST00000578202MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000495303ENST00000354792MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000495303ENST00000346322MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000495303ENST00000583087MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000495303ENST00000475616MYD88chr3

38181436

+MYLKchr3

123383107

-
intron-intronENST00000495303ENST00000510775MYD88chr3

38181436

+MYLKchr3

123383107

-
Frame-shiftENST00000443433ENST00000360772MYD88chr3

38181436

+MYLKchr3

123383107

-
Frame-shiftENST00000443433ENST00000359169MYD88chr3

38181436

+MYLKchr3

123383107

-
Frame-shiftENST00000443433ENST00000360304MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000443433ENST00000418370MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000443433ENST00000578202MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000443433ENST00000354792MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000443433ENST00000346322MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000443433ENST00000583087MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000443433ENST00000475616MYD88chr3

38181436

+MYLKchr3

123383107

-
5CDS-intronENST00000443433ENST00000510775MYD88chr3

38181436

+MYLKchr3

123383107

-
3UTR-3CDSENST00000481122ENST00000360772MYD88chr3

38181436

+MYLKchr3

123383107

-
3UTR-3CDSENST00000481122ENST00000359169MYD88chr3

38181436

+MYLKchr3

123383107

-
3UTR-3CDSENST00000481122ENST00000360304MYD88chr3

38181436

+MYLKchr3

123383107

-
3UTR-intronENST00000481122ENST00000418370MYD88chr3

38181436

+MYLKchr3

123383107

-
3UTR-intronENST00000481122ENST00000578202MYD88chr3

38181436

+MYLKchr3

123383107

-
3UTR-intronENST00000481122ENST00000354792MYD88chr3

38181436

+MYLKchr3

123383107

-
3UTR-intronENST00000481122ENST00000346322MYD88chr3

38181436

+MYLKchr3

123383107

-
3UTR-intronENST00000481122ENST00000583087MYD88chr3

38181436

+MYLKchr3

123383107

-
3UTR-intronENST00000481122ENST00000475616MYD88chr3

38181436

+MYLKchr3

123383107

-
3UTR-intronENST00000481122ENST00000510775MYD88chr3

38181436

+MYLKchr3

123383107

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MYD88-MYLK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYD88-MYLK


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYLK

Q86YV6

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MYD88-MYLK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MYD88-MYLK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYD88-MYLK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMYLKQ86YV6DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneMYLKQ86YV6DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for MYD88-MYLK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYD88C2677092MYD88 Deficiency5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneMYD88C0024419Waldenstrom Macroglobulinemia3CGI;CTD_human;ORPHANET
HgeneMYD88C0005398Cholestasis, Extrahepatic1CTD_human
HgeneMYD88C0007621Neoplastic Cell Transformation1CTD_human
HgeneMYD88C0014457Eosinophilia1CTD_human
HgeneMYD88C0014458Eosinophilia, Tropical1CTD_human
HgeneMYD88C0020538Hypertensive disease1CTD_human
HgeneMYD88C0021368Inflammation1CTD_human
HgeneMYD88C0024301Lymphoma, Follicular1CTD_human
HgeneMYD88C0027626Neoplasm Invasiveness1CTD_human
HgeneMYD88C0032285Pneumonia1CTD_human
HgeneMYD88C0032300Lobar Pneumonia1CTD_human
HgeneMYD88C0034068Pulmonary Eosinophilia1CTD_human
HgeneMYD88C0035126Reperfusion Injury1CTD_human
HgeneMYD88C0079744Diffuse Large B-Cell Lymphoma1CGI;CTD_human
HgeneMYD88C0079745Lymphoma, Large-Cell, Follicular1CTD_human
HgeneMYD88C0079758Lymphoma, Mixed-Cell, Follicular1CTD_human
HgeneMYD88C0079765Lymphoma, Small Cleaved-Cell, Follicular1CTD_human
HgeneMYD88C0242459Simple Pulmonary Eosinophilia1CTD_human
HgeneMYD88C0344315Depressed mood1PSYGENET
HgeneMYD88C0887898Experimental Lung Inflammation1CTD_human
HgeneMYD88C1527407Eosinophilic Pneumonia1CTD_human
HgeneMYD88C1956130Lymphoma, Follicular, Grade 11CTD_human
HgeneMYD88C1956131Lymphoma, Follicular, Grade 31CTD_human
HgeneMYD88C1956132Lymphoma, Follicular, Grade 21CTD_human
HgeneMYD88C2350879Tropical Eosinophilic Pneumonia1CTD_human
HgeneMYD88C2936755Familial Waldenstrom's Macroglobulinaemia1CTD_human
HgeneMYD88C3714636Pneumonitis1CTD_human
TgeneMYLKC4707243Familial thoracic aortic aneurysm and aortic dissection6CLINGEN;GENOMICS_ENGLAND
TgeneMYLKC3151077AORTIC ANEURYSM, FAMILIAL THORACIC 73CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneMYLKC0027626Neoplasm Invasiveness2CTD_human
TgeneMYLKC0027627Neoplasm Metastasis2CTD_human
TgeneMYLKC0006114Cerebral Edema1CTD_human
TgeneMYLKC0017178Gastrointestinal Diseases1CTD_human
TgeneMYLKC0017601Glaucoma1CTD_human
TgeneMYLKC0017638Glioma1CTD_human
TgeneMYLKC0020443Hypercholesterolemia1CTD_human
TgeneMYLKC0020517Hypersensitivity1CTD_human
TgeneMYLKC0032285Pneumonia1CTD_human
TgeneMYLKC0032300Lobar Pneumonia1CTD_human
TgeneMYLKC0042373Vascular Diseases1CTD_human
TgeneMYLKC0242488Acute Lung Injury1CTD_human
TgeneMYLKC0259783mixed gliomas1CTD_human
TgeneMYLKC0345050Congenital aneurysm of ascending aorta1GENOMICS_ENGLAND
TgeneMYLKC0472387Vasogenic Cerebral Edema1CTD_human
TgeneMYLKC0472388Cytotoxic Cerebral Edema1CTD_human
TgeneMYLKC0555198Malignant Glioma1CTD_human
TgeneMYLKC0559031Functional Gastrointestinal Disorders1CTD_human
TgeneMYLKC0750969Vasogenic Brain Edema1CTD_human
TgeneMYLKC0750970Cytotoxic Brain Edema1CTD_human
TgeneMYLKC0887898Experimental Lung Inflammation1CTD_human
TgeneMYLKC1527304Allergic Reaction1CTD_human
TgeneMYLKC1527311Brain Edema1CTD_human
TgeneMYLKC1565321Cholera Infantum1CTD_human
TgeneMYLKC1608393Megacystis microcolon intestinal hypoperistalsis syndrome1GENOMICS_ENGLAND;ORPHANET
TgeneMYLKC3714636Pneumonitis1CTD_human