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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYH9-CACNA1C (FusionGDB2 ID:56032)

Fusion Gene Summary for MYH9-CACNA1C

check button Fusion gene summary
Fusion gene informationFusion gene name: MYH9-CACNA1C
Fusion gene ID: 56032
HgeneTgene
Gene symbol

MYH9

CACNA1C

Gene ID

4627

775

Gene namemyosin heavy chain 9calcium voltage-gated channel subunit alpha1 C
SynonymsBDPLT6|DFNA17|EPSTS|FTNS|MATINS|MHA|NMHC-II-A|NMMHC-IIA|NMMHCACACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|LQT8|TS|TS. LQT8
Cytomap

22q12.3

12p13.33

Type of geneprotein-codingprotein-coding
Descriptionmyosin-9cellular myosin heavy chain, type Amyosin, heavy chain 9, non-musclenon-muscle myosin heavy chain 9non-muscle myosin heavy chain Anon-muscle myosin heavy chain IIanon-muscle myosin heavy polypeptide 9nonmuscle myosin heavy chain II-Avoltage-dependent L-type calcium channel subunit alpha-1CDHPR, alpha-1 subunitcalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac musclecalcium channel, cardic dihydropyridine-sensitive, alpha-1 subunitcalcium channel, voltage-dependent,
Modification date2020031520200315
UniProtAcc.

Q13936

Ensembl transtripts involved in fusion geneENST00000216181, ENST00000475726, 
ENST00000401701, 		ENST00000335762, 
ENST00000399655, ENST00000480911, 
ENST00000399644, ENST00000344100, 
ENST00000399638, ENST00000399629, 
ENST00000399597, ENST00000327702, 
ENST00000399621, ENST00000399649, 
ENST00000399637, ENST00000402845, 
ENST00000399591, ENST00000399641, 
ENST00000347598, ENST00000399606, 
ENST00000399595, ENST00000399601, 
ENST00000399603, ENST00000399634, 
ENST00000399617, ENST00000406454, 
ENST00000491104, 
Fusion gene scores* DoF score55 X 51 X 22=6171021 X 20 X 10=4200
# samples 7724
** MAII scorelog2(77/61710*10)=-6.32450203855119
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/4200*10)=-4.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYH9 [Title/Abstract] AND CACNA1C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYH9(36783852)-CACNA1C(2224390), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYH9

GO:0001525

angiogenesis

16403913

HgeneMYH9

GO:0001778

plasma membrane repair

27325790

HgeneMYH9

GO:0006509

membrane protein ectodomain proteolysis

16186248

HgeneMYH9

GO:0030048

actin filament-based movement

12237319|15845534

HgeneMYH9

GO:0031032

actomyosin structure organization

24072716

TgeneCACNA1C

GO:0007204

positive regulation of cytosolic calcium ion concentration

12130699

TgeneCACNA1C

GO:0061577

calcium ion transmembrane transport via high voltage-gated calcium channel

15454078

TgeneCACNA1C

GO:0070588

calcium ion transmembrane transport

15454078


check buttonFusion gene breakpoints across MYH9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CACNA1C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2943-03AMYH9chr22

36783852

-CACNA1Cchr12

2224390

+


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Fusion Gene ORF analysis for MYH9-CACNA1C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000216181ENST00000335762MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399655MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000480911MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399644MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000344100MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399638MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399629MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399597MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000327702MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399621MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399649MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399637MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000402845MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399591MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399641MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000347598MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399606MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399595MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399601MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399603MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399634MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000399617MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-3CDSENST00000216181ENST00000406454MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
5UTR-intronENST00000216181ENST00000491104MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000335762MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399655MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000480911MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399644MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000344100MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399638MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399629MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399597MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000327702MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399621MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399649MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399637MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000402845MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399591MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399641MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000347598MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399606MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399595MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399601MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399603MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399634MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000399617MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000475726ENST00000406454MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-intronENST00000475726ENST00000491104MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000335762MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399655MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000480911MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399644MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000344100MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399638MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399629MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399597MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000327702MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399621MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399649MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399637MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000402845MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399591MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399641MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000347598MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399606MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399595MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399601MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399603MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399634MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000399617MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-3CDSENST00000401701ENST00000406454MYH9chr22

36783852

-CACNA1Cchr12

2224390

+
intron-intronENST00000401701ENST00000491104MYH9chr22

36783852

-CACNA1Cchr12

2224390

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MYH9-CACNA1C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYH9-CACNA1C


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CACNA1C

Q13936

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:23677916). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:11741969, ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17071743, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:7737988, ECO:0000269|PubMed:8099908, ECO:0000269|PubMed:8392192, ECO:0000269|PubMed:9013606, ECO:0000269|PubMed:9087614, ECO:0000269|PubMed:9607315, ECO:0000305}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MYH9-CACNA1C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MYH9-CACNA1C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYH9-CACNA1C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCACNA1CQ13936DB00308IbutilideActivatorSmall moleculeApproved
TgeneCACNA1CQ13936DB00308IbutilideActivatorSmall moleculeApproved
TgeneCACNA1CQ13936DB00308IbutilideActivatorSmall moleculeApproved
TgeneCACNA1CQ13936DB00308IbutilideActivatorSmall moleculeApproved
TgeneCACNA1CQ13936DB00308IbutilideActivatorSmall moleculeApproved
TgeneCACNA1CQ13936DB00381AmlodipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00381AmlodipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00381AmlodipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00381AmlodipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00381AmlodipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00401NisoldipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00401NisoldipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00401NisoldipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00401NisoldipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00401NisoldipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00661VerapamilInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00661VerapamilInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00661VerapamilInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00661VerapamilInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00661VerapamilInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00898EthanolSmall moleculeApproved
TgeneCACNA1CQ13936DB00898EthanolSmall moleculeApproved
TgeneCACNA1CQ13936DB00898EthanolSmall moleculeApproved
TgeneCACNA1CQ13936DB00898EthanolSmall moleculeApproved
TgeneCACNA1CQ13936DB00898EthanolSmall moleculeApproved
TgeneCACNA1CQ13936DB01115NifedipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB01115NifedipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB01115NifedipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB01115NifedipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB01115NifedipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB04855DronedaroneInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB04855DronedaroneInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB04855DronedaroneInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB04855DronedaroneInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB04855DronedaroneInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00270IsradipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00270IsradipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00270IsradipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00270IsradipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00270IsradipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00343DiltiazemBlockerSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00343DiltiazemBlockerSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00343DiltiazemBlockerSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00343DiltiazemBlockerSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00343DiltiazemBlockerSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00393NimodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00393NimodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00393NimodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00393NimodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00393NimodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00568CinnarizineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00568CinnarizineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00568CinnarizineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00568CinnarizineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00568CinnarizineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00622NicardipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00622NicardipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00622NicardipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00622NicardipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00622NicardipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01023FelodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01023FelodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01023FelodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01023FelodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01023FelodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01054NitrendipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01054NitrendipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01054NitrendipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01054NitrendipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01054NitrendipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB04920ClevidipineSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB04920ClevidipineSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB04920ClevidipineSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB04920ClevidipineSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB04920ClevidipineSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06712NilvadipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06712NilvadipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06712NilvadipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06712NilvadipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06712NilvadipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06751DrotaverineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06751DrotaverineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06751DrotaverineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06751DrotaverineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06751DrotaverineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB09237LevamlodipineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB09237LevamlodipineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB09237LevamlodipineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB09237LevamlodipineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB09237LevamlodipineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB12278PropiverineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB12278PropiverineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB12278PropiverineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB12278PropiverineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB12278PropiverineAntagonistSmall moleculeApproved|Investigational

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Related Diseases for MYH9-CACNA1C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYH9C0340978May-Hegglin anomaly25CLINGEN;GENOMICS_ENGLAND;UNIPROT
HgeneMYH9C1854520SEBASTIAN SYNDROME14CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneMYH9C0398641Epstein syndrome (disorder)11CLINGEN
HgeneMYH9C0403445Fechtner syndrome (disorder)11CLINGEN
HgeneMYH9C0477317Other primary thrombocytopenia11CLINGEN
HgeneMYH9C1842035Giant Platelet Syndrome with Thrombocytopenia11CLINGEN
HgeneMYH9C1863659DEAFNESS, AUTOSOMAL DOMINANT 176CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneMYH9C0022661Kidney Failure, Chronic2CTD_human
HgeneMYH9C0006142Malignant neoplasm of breast1CTD_human;UNIPROT
HgeneMYH9C0017668Focal glomerulosclerosis1CTD_human
HgeneMYH9C0018784Sensorineural Hearing Loss (disorder)1GENOMICS_ENGLAND
HgeneMYH9C0018965Hematuria1GENOMICS_ENGLAND
HgeneMYH9C0020544Renal hypertension1CTD_human
HgeneMYH9C0027626Neoplasm Invasiveness1CTD_human
HgeneMYH9C0027706Hereditary nephritis1CTD_human
HgeneMYH9C0033687Proteinuria1GENOMICS_ENGLAND
HgeneMYH9C0035078Kidney Failure1GENOMICS_ENGLAND
HgeneMYH9C0086432Hyalinosis, Segmental Glomerular1CTD_human
HgeneMYH9C0086543Cataract1GENOMICS_ENGLAND
HgeneMYH9C0206692Carcinoma, Lobular1CTD_human
HgeneMYH9C0410005Nodular fasciitis1ORPHANET
HgeneMYH9C0678222Breast Carcinoma1CTD_human
HgeneMYH9C1257931Mammary Neoplasms, Human1CTD_human
HgeneMYH9C1458155Mammary Neoplasms1CTD_human
HgeneMYH9C1567741Alport Syndrome1CTD_human
HgeneMYH9C1567742Alport Syndrome, X-Linked1CTD_human
HgeneMYH9C1567743Alport Syndrome, Autosomal Dominant1CTD_human
HgeneMYH9C1567744Alport Syndrome, Autosomal Recessive1CTD_human
HgeneMYH9C1834478MACROTHROMBOCYTOPENIA AND PROGRESSIVE SENSORINEURAL DEAFNESS1CTD_human
HgeneMYH9C2931861Hemorrhagic hereditary nephritis1CTD_human
HgeneMYH9C4280711Leukocyte inclusion bodies1GENOMICS_ENGLAND
HgeneMYH9C4704874Mammary Carcinoma, Human1CTD_human
TgeneCACNA1CC0005586Bipolar Disorder9CTD_human;PSYGENET
TgeneCACNA1CC1832916Timothy syndrome8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCACNA1CC1142166Brugada Syndrome (disorder)7CLINGEN;GENOMICS_ENGLAND
TgeneCACNA1CC1269683Major Depressive Disorder6CTD_human;PSYGENET
TgeneCACNA1CC0011570Mental Depression5PSYGENET
TgeneCACNA1CC0011581Depressive disorder5PSYGENET
TgeneCACNA1CC0041696Unipolar Depression5PSYGENET
TgeneCACNA1CC0525045Mood Disorders5PSYGENET
TgeneCACNA1CC2678478Brugada Syndrome 35CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneCACNA1CC0005587Depression, Bipolar4CTD_human
TgeneCACNA1CC0024713Manic Disorder4CTD_human
TgeneCACNA1CC0036341Schizophrenia4PSYGENET
TgeneCACNA1CC0338831Manic4CTD_human
TgeneCACNA1CC0033975Psychotic Disorders3PSYGENET
TgeneCACNA1CC0178417Anhedonia2PSYGENET
TgeneCACNA1CC0002895Anemia, Sickle Cell1GENOMICS_ENGLAND
TgeneCACNA1CC0003257Antibody Deficiency Syndrome1CTD_human
TgeneCACNA1CC0003469Anxiety Disorders1CTD_human
TgeneCACNA1CC0003811Cardiac Arrhythmia1CTD_human
TgeneCACNA1CC0004352Autistic Disorder1CTD_human
TgeneCACNA1CC0007194Hypertrophic Cardiomyopathy1GENOMICS_ENGLAND
TgeneCACNA1CC0011574Involutional Depression1CTD_human
TgeneCACNA1CC0020538Hypertensive disease1CTD_human
TgeneCACNA1CC0020615Hypoglycemia1CTD_human
TgeneCACNA1CC0021051Immunologic Deficiency Syndromes1CTD_human
TgeneCACNA1CC0038441Stress Disorders, Traumatic1CTD_human
TgeneCACNA1CC0039070Syncope1GENOMICS_ENGLAND
TgeneCACNA1CC0085298Sudden Cardiac Death1GENOMICS_ENGLAND
TgeneCACNA1CC0151879Shortened QT interval1GENOMICS_ENGLAND
TgeneCACNA1CC0206762Limb Deformities, Congenital1CTD_human
TgeneCACNA1CC0234985Mental deterioration1CTD_human
TgeneCACNA1CC0271708Fasting Hypoglycemia1CTD_human
TgeneCACNA1CC0271710Reactive hypoglycemia1CTD_human
TgeneCACNA1CC0338656Impaired cognition1CTD_human
TgeneCACNA1CC0342788Renal carnitine transport defect1GENOMICS_ENGLAND
TgeneCACNA1CC0349204Nonorganic psychosis1PSYGENET
TgeneCACNA1CC0376280Anxiety States, Neurotic1CTD_human
TgeneCACNA1CC0392156Akathisia1CTD_human
TgeneCACNA1CC1270972Mild cognitive disorder1CTD_human
TgeneCACNA1CC1279420Anxiety neurosis (finding)1CTD_human
TgeneCACNA1CC1571983Involutional paraphrenia1CTD_human
TgeneCACNA1CC1571984Psychosis, Involutional1CTD_human
TgeneCACNA1CC3887612Psychomotor Agitation1CTD_human