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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYL6-LSM5 (FusionGDB2 ID:56131)

Fusion Gene Summary for MYL6-LSM5

check button Fusion gene summary
Fusion gene informationFusion gene name: MYL6-LSM5
Fusion gene ID: 56131
HgeneTgene
Gene symbol

MYL6

LSM5

Gene ID

4637

23658

Gene namemyosin light chain 6LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
SynonymsESMLC|LC17|LC17-GI|LC17-NM|LC17A|LC17B|MLC-3|MLC1SM|MLC3NM|MLC3SMYER146W
Cytomap

12q13.2

7p14.3

Type of geneprotein-codingprotein-coding
Descriptionmyosin light polypeptide 617 kDa myosin light chainmyosin light chain A3myosin light chain alkali 3myosin, light chain 6, alkali, smooth muscle and non-musclemyosin, light polypeptide 6, alkali, smooth muscle and non-muscleU6 snRNA-associated Sm-like protein LSm5LSM5 U6 small nuclear RNA and mRNA degradation associatedLSM5 homolog, U6 small nuclear RNA associated
Modification date2020031320200313
UniProtAcc.

Q9Y4Y9

Ensembl transtripts involved in fusion geneENST00000550697, ENST00000548580, 
ENST00000293422, ENST00000348108, 
ENST00000549017, ENST00000549566, 
ENST00000536128, ENST00000547649, 
ENST00000547408, ENST00000551589, 
ENST00000548400, ENST00000548293, 
ENST00000551954, 		ENST00000450169, 
ENST00000409909, ENST00000409292, 
ENST00000410044, ENST00000409987, 
ENST00000409782, ENST00000409952, 
Fusion gene scores* DoF score34 X 17 X 10=57803 X 2 X 2=12
# samples 363
** MAII scorelog2(36/5780*10)=-4.00500068105837
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MYL6 [Title/Abstract] AND LSM5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYL6(56553406)-LSM5(32528956), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLSM5

GO:0000398

mRNA splicing, via spliceosome

28781166

TgeneLSM5

GO:0006402

mRNA catabolic process

12515382


check buttonFusion gene breakpoints across MYL6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LSM5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5799-01AMYL6chr12

56553406

+LSM5chr7

32528956

-


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Fusion Gene ORF analysis for MYL6-LSM5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000550697ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000550697ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000550697ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000550697ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000550697ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000550697ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000550697ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-3CDSENST00000548580ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000548580ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000548580ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000548580ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000548580ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000548580ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000548580ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
In-frameENST00000293422ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000293422ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000293422ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000293422ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000293422ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000293422ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000293422ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
In-frameENST00000348108ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000348108ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000348108ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000348108ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000348108ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000348108ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000348108ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
5UTR-3CDSENST00000549017ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
5UTR-5UTRENST00000549017ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
5UTR-5UTRENST00000549017ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
5UTR-5UTRENST00000549017ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
5UTR-5UTRENST00000549017ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
5UTR-5UTRENST00000549017ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
5UTR-5UTRENST00000549017ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-3CDSENST00000549566ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000549566ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000549566ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000549566ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000549566ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000549566ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000549566ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
In-frameENST00000536128ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000536128ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000536128ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000536128ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000536128ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000536128ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000536128ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
In-frameENST00000547649ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547649ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547649ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547649ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547649ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547649ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547649ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
In-frameENST00000547408ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547408ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547408ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547408ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547408ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547408ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000547408ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
In-frameENST00000551589ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000551589ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000551589ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000551589ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000551589ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000551589ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000551589ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
In-frameENST00000548400ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548400ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548400ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548400ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548400ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548400ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548400ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
In-frameENST00000548293ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548293ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548293ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548293ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548293ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548293ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
5CDS-5UTRENST00000548293ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-3CDSENST00000551954ENST00000450169MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000551954ENST00000409909MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000551954ENST00000409292MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000551954ENST00000410044MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000551954ENST00000409987MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000551954ENST00000409782MYL6chr12

56553406

+LSM5chr7

32528956

-
intron-5UTRENST00000551954ENST00000409952MYL6chr12

56553406

+LSM5chr7

32528956

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000550697MYL6chr1256553406+ENST00000450169LSM5chr732528956-2532380241609122
ENST00000293422MYL6chr1256553406+ENST00000450169LSM5chr732528956-234018846417123
ENST00000348108MYL6chr1256553406+ENST00000450169LSM5chr732528956-234018846417123
ENST00000536128MYL6chr1256553406+ENST00000450169LSM5chr732528956-261045840687215
ENST00000547649MYL6chr1256553406+ENST00000450169LSM5chr732528956-233117940408122
ENST00000547408MYL6chr1256553406+ENST00000450169LSM5chr732528956-232517334402122
ENST00000551589MYL6chr1256553406+ENST00000450169LSM5chr732528956-232417233401122
ENST00000548400MYL6chr1256553406+ENST00000450169LSM5chr732528956-22398714601768102
ENST00000548293MYL6chr1256553406+ENST00000450169LSM5chr732528956-22971456374122

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000550697ENST00000450169MYL6chr1256553406+LSM5chr732528956-0.0100840590.9899159
ENST00000293422ENST00000450169MYL6chr1256553406+LSM5chr732528956-0.0105573650.9894426
ENST00000348108ENST00000450169MYL6chr1256553406+LSM5chr732528956-0.0105573650.9894426
ENST00000536128ENST00000450169MYL6chr1256553406+LSM5chr732528956-0.0010777650.9989222
ENST00000547649ENST00000450169MYL6chr1256553406+LSM5chr732528956-0.0152899630.98471004
ENST00000547408ENST00000450169MYL6chr1256553406+LSM5chr732528956-0.0133599560.98664004
ENST00000551589ENST00000450169MYL6chr1256553406+LSM5chr732528956-0.0158029720.98419696
ENST00000548400ENST00000450169MYL6chr1256553406+LSM5chr732528956-0.0202644110.9797356
ENST00000548293ENST00000450169MYL6chr1256553406+LSM5chr732528956-0.0098925280.9901074

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Fusion Genomic Features for MYL6-LSM5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYL6-LSM5


check button Go to

FGviewer for the breakpoints of chr12:56553406-chr7:32528956

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LSM5

Q9Y4Y9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYL6chr12:56553406chr7:32528956ENST00000547649+16119_1510152.0DomainEF-hand 3
HgeneMYL6chr12:56553406chr7:32528956ENST00000547649+167_420152.0DomainEF-hand 1
HgeneMYL6chr12:56553406chr7:32528956ENST00000547649+1684_1190152.0DomainEF-hand 2
HgeneMYL6chr12:56553406chr7:32528956ENST00000548293+16119_1510152.0DomainEF-hand 3
HgeneMYL6chr12:56553406chr7:32528956ENST00000548293+167_420152.0DomainEF-hand 1
HgeneMYL6chr12:56553406chr7:32528956ENST00000548293+1684_1190152.0DomainEF-hand 2
HgeneMYL6chr12:56553406chr7:32528956ENST00000550697+17119_1510133.33333333333334DomainEF-hand 3
HgeneMYL6chr12:56553406chr7:32528956ENST00000550697+177_420133.33333333333334DomainEF-hand 1
HgeneMYL6chr12:56553406chr7:32528956ENST00000550697+1784_1190133.33333333333334DomainEF-hand 2


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Fusion Gene Sequence for MYL6-LSM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000550697_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(transcript)=2532nt_BP=380nt
CTCCCCCCACGACCCCCCCCACCTCCGAGCGGGTTCTGTGCCCAGGTGGCGCTGGAGAAAGGAACAGCGGACCCCGCCCAAGTCATTACT
AATGTAGCAATCGTCTGCATAAACCCAGGCCACGGTTCCTATTGGCTGAGTCCTCTGAGGGTGACGTCATCGGGACGTACTAAGACTAGG
GTTGGGCCGAGAGTCGGAGCCATTACTGCAGGAAAAGGTCCCGGAGAGCTGAGCAGTCAAGATGTGTGACTTCACCGAAGACCAGACCGC
AGGTGATGGCAAGATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCT
GGGGAACCCCAAGAGTGATGAGCTTGTGGACAAATGTATAGGATCAAGAATTCACATCGTGATGAAGAGTGATAAGGAAATTGTTGGTAC
TCTTCTAGGATTTGATGACTTTGTCAATATGGTACTGGAAGATGTCACTGAGTTTGAAATCACACCAGAAGGAAGAAGGATTACTAAATT
AGATCAGATTTTGCTAAATGGAAATAATATAACAATGCTGGTTCCTGGAGGAGAAGGACCTGAAGTGTGAATGAGTTTCCTTGACTTACA
CTAGATTTTGTTTTGGCTTATAATGACAAGAAAATGGAATTTTTTTTCCCACTTTCTAATGTTTAAATCCCATAAAGCTAAGTTTCCCGT
TAAAGGGAAGTGCTTTGAAGATGTGTACCCATTTTTGTAAGTTAATCATGATTATCCTGGAAAAAGAAGAAAAGAGCTTCTTCTTTGCAG
ATGAAAATAAAGGTGTTTTTGGTTAACTGTCATTTTGTTTATTCTACTGCAGTAGCCAGTGGAACAAAGTTTGTAGTTATTTTGCCACTT
ACTTTTCTGTCATTATATGCTTATTTGTTTTGTCATTTACGTGACCATTTGATTCTCAAACAAAAGTTGTTCCAAACAAAATGATGAACT
TTGATTTGAACAGGTGCATTTAAACAACCGGAAATGATCACTTAGAAAATTCAATTAAAATGCTGTTGTTTTGTAATGAGGATTTTTCTT
CTGATTTCAAATTCCATGAACTCCTATTGAAAACAAACAATGTACAGGTAATATATGCACATTGTAGAAATGCAGGAATTATCTATTGGA
ATTACCCTAAAGATAGAAATTTTATCTATTTGCTTATAAAATTGATTCAGAAGGTTATTACCTTAATGTAGTTATTACTGAATTGCCAGG
AAATGAGTGGAGACAGAGCTTTAAGATAAAGGATACTAAAAGCAGCTAAGAACTCCAGGACTCAGGTCAAATCAAGGAACTGATAATAAG
ATCATTGAACTGTATAAATTAAGTCAAAGAACTCCTATTAAAAACAAACAGGTAATATATGCACATCGTAGAATTGTAGGTAAGCAAAAA
GGAGAAGGTTGATCATGCTTTGCTGTATGTCTTCGTAGACTTTCTCAGTCCACTCTCAGTACACGTTTTATTTTACTTGCTCATCCTGAT
TATACTGTTTTTACCCTCCACTTAAGTCATTTTTTGAATTTAAATGGTGAATATCTTTCTGTGTCAAATATTTCAACATTAATATGTACA
TAGTATTAAATGGATTTACTATAAATTATTTAGCCTATTCTTACTGGCCACAGTAGTCTAACTAGATCTTTATACATTTGTATTTTTCTA
GAATAAACTCAAAAATGTGTAAGATCAAAGGGTATATATTGTGTTGCCAAGAAAAAGTTTGTGCCAATGTATATTTTTGCCAGGAGTCTT
TCATAGTACCATTTATATCCTTCCCAGCATTAGCTGTGTTCTACCTTCTCTCCTCTTTGCCATTTTTACAAGAAAACCGGGCATGTCTAA
AGTTTTCTTTTCCTTTTTTTTTTTTTTTTTTTTTTTTTGGAGAGTCTCACTGGAATGCAGTGGCATGATCTTGGCTCCCTGCAACCTCCA
GTCAGGCTGGTGTGCCTTGTCGCGATATCAACGCGACCTCCGCCTCCCAGGTTCAAGTGATTGTCCTGCCTCACCCTCCTGAGTAGCTGG
GATTACAGGTGGGCGCCACCACTCCCATCTAATTTTTATATTTTTAGAGAGATGGGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTC
CTGACCTCTAGTGATCCACCTGCCTCAGCCTCCCAAAGTGCCGGTATTAAAGGCATGAGCCACCAGGCCTGGCCTAAAATTTTCTTGATT
AATTTTGATCTCATTTGTATTTTGTAAATGACTTATCTGTTGAGGCTTTTGCCATTGAGATGTTTGTCTTTTTCTTACTAATTTGTAAGA
ATTCTTGATGGGTTTCTGTTAGTCATGTATTTTGCTAATAATTTCCCTAGTTTGTAGTTTGCCACTTAGTGCTATTTTTGACATAAATGA
TGTATTTTAATGTAGTTGCATGTTGACCTAGTCCATTATGGTTTTTGTATTTGGTCCACGTGGATTGGAAAACCTTTGCTTTGATTATAC

>In-frame_ENST00000550697_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(amino acids)=122AA_start in transcript=241_stop in transcript=609
MCDFTEDQTAGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEI

--------------------------------------------------------------
>In-frame_ENST00000293422_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(transcript)=2340nt_BP=188nt
GGAGCCATTACTGCAGGAAAAGGTCCCGGAGAGCTGAGCAGTCAAGATGCAGTGTGACTTCACCGAAGACCAGACCGCAGGTGATGGCAA
GATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAA
GAGTGATGAGCTTGTGGACAAATGTATAGGATCAAGAATTCACATCGTGATGAAGAGTGATAAGGAAATTGTTGGTACTCTTCTAGGATT
TGATGACTTTGTCAATATGGTACTGGAAGATGTCACTGAGTTTGAAATCACACCAGAAGGAAGAAGGATTACTAAATTAGATCAGATTTT
GCTAAATGGAAATAATATAACAATGCTGGTTCCTGGAGGAGAAGGACCTGAAGTGTGAATGAGTTTCCTTGACTTACACTAGATTTTGTT
TTGGCTTATAATGACAAGAAAATGGAATTTTTTTTCCCACTTTCTAATGTTTAAATCCCATAAAGCTAAGTTTCCCGTTAAAGGGAAGTG
CTTTGAAGATGTGTACCCATTTTTGTAAGTTAATCATGATTATCCTGGAAAAAGAAGAAAAGAGCTTCTTCTTTGCAGATGAAAATAAAG
GTGTTTTTGGTTAACTGTCATTTTGTTTATTCTACTGCAGTAGCCAGTGGAACAAAGTTTGTAGTTATTTTGCCACTTACTTTTCTGTCA
TTATATGCTTATTTGTTTTGTCATTTACGTGACCATTTGATTCTCAAACAAAAGTTGTTCCAAACAAAATGATGAACTTTGATTTGAACA
GGTGCATTTAAACAACCGGAAATGATCACTTAGAAAATTCAATTAAAATGCTGTTGTTTTGTAATGAGGATTTTTCTTCTGATTTCAAAT
TCCATGAACTCCTATTGAAAACAAACAATGTACAGGTAATATATGCACATTGTAGAAATGCAGGAATTATCTATTGGAATTACCCTAAAG
ATAGAAATTTTATCTATTTGCTTATAAAATTGATTCAGAAGGTTATTACCTTAATGTAGTTATTACTGAATTGCCAGGAAATGAGTGGAG
ACAGAGCTTTAAGATAAAGGATACTAAAAGCAGCTAAGAACTCCAGGACTCAGGTCAAATCAAGGAACTGATAATAAGATCATTGAACTG
TATAAATTAAGTCAAAGAACTCCTATTAAAAACAAACAGGTAATATATGCACATCGTAGAATTGTAGGTAAGCAAAAAGGAGAAGGTTGA
TCATGCTTTGCTGTATGTCTTCGTAGACTTTCTCAGTCCACTCTCAGTACACGTTTTATTTTACTTGCTCATCCTGATTATACTGTTTTT
ACCCTCCACTTAAGTCATTTTTTGAATTTAAATGGTGAATATCTTTCTGTGTCAAATATTTCAACATTAATATGTACATAGTATTAAATG
GATTTACTATAAATTATTTAGCCTATTCTTACTGGCCACAGTAGTCTAACTAGATCTTTATACATTTGTATTTTTCTAGAATAAACTCAA
AAATGTGTAAGATCAAAGGGTATATATTGTGTTGCCAAGAAAAAGTTTGTGCCAATGTATATTTTTGCCAGGAGTCTTTCATAGTACCAT
TTATATCCTTCCCAGCATTAGCTGTGTTCTACCTTCTCTCCTCTTTGCCATTTTTACAAGAAAACCGGGCATGTCTAAAGTTTTCTTTTC
CTTTTTTTTTTTTTTTTTTTTTTTTTGGAGAGTCTCACTGGAATGCAGTGGCATGATCTTGGCTCCCTGCAACCTCCAGTCAGGCTGGTG
TGCCTTGTCGCGATATCAACGCGACCTCCGCCTCCCAGGTTCAAGTGATTGTCCTGCCTCACCCTCCTGAGTAGCTGGGATTACAGGTGG
GCGCCACCACTCCCATCTAATTTTTATATTTTTAGAGAGATGGGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTAGT
GATCCACCTGCCTCAGCCTCCCAAAGTGCCGGTATTAAAGGCATGAGCCACCAGGCCTGGCCTAAAATTTTCTTGATTAATTTTGATCTC
ATTTGTATTTTGTAAATGACTTATCTGTTGAGGCTTTTGCCATTGAGATGTTTGTCTTTTTCTTACTAATTTGTAAGAATTCTTGATGGG
TTTCTGTTAGTCATGTATTTTGCTAATAATTTCCCTAGTTTGTAGTTTGCCACTTAGTGCTATTTTTGACATAAATGATGTATTTTAATG
TAGTTGCATGTTGACCTAGTCCATTATGGTTTTTGTATTTGGTCCACGTGGATTGGAAAACCTTTGCTTTGATTATACTTTTCTTTGGGC

>In-frame_ENST00000293422_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(amino acids)=123AA_start in transcript=46_stop in transcript=417
MQCDFTEDQTAGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFE

--------------------------------------------------------------
>In-frame_ENST00000348108_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(transcript)=2340nt_BP=188nt
GGAGCCATTACTGCAGGAAAAGGTCCCGGAGAGCTGAGCAGTCAAGATGCAGTGTGACTTCACCGAAGACCAGACCGCAGGTGATGGCAA
GATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAA
GAGTGATGAGCTTGTGGACAAATGTATAGGATCAAGAATTCACATCGTGATGAAGAGTGATAAGGAAATTGTTGGTACTCTTCTAGGATT
TGATGACTTTGTCAATATGGTACTGGAAGATGTCACTGAGTTTGAAATCACACCAGAAGGAAGAAGGATTACTAAATTAGATCAGATTTT
GCTAAATGGAAATAATATAACAATGCTGGTTCCTGGAGGAGAAGGACCTGAAGTGTGAATGAGTTTCCTTGACTTACACTAGATTTTGTT
TTGGCTTATAATGACAAGAAAATGGAATTTTTTTTCCCACTTTCTAATGTTTAAATCCCATAAAGCTAAGTTTCCCGTTAAAGGGAAGTG
CTTTGAAGATGTGTACCCATTTTTGTAAGTTAATCATGATTATCCTGGAAAAAGAAGAAAAGAGCTTCTTCTTTGCAGATGAAAATAAAG
GTGTTTTTGGTTAACTGTCATTTTGTTTATTCTACTGCAGTAGCCAGTGGAACAAAGTTTGTAGTTATTTTGCCACTTACTTTTCTGTCA
TTATATGCTTATTTGTTTTGTCATTTACGTGACCATTTGATTCTCAAACAAAAGTTGTTCCAAACAAAATGATGAACTTTGATTTGAACA
GGTGCATTTAAACAACCGGAAATGATCACTTAGAAAATTCAATTAAAATGCTGTTGTTTTGTAATGAGGATTTTTCTTCTGATTTCAAAT
TCCATGAACTCCTATTGAAAACAAACAATGTACAGGTAATATATGCACATTGTAGAAATGCAGGAATTATCTATTGGAATTACCCTAAAG
ATAGAAATTTTATCTATTTGCTTATAAAATTGATTCAGAAGGTTATTACCTTAATGTAGTTATTACTGAATTGCCAGGAAATGAGTGGAG
ACAGAGCTTTAAGATAAAGGATACTAAAAGCAGCTAAGAACTCCAGGACTCAGGTCAAATCAAGGAACTGATAATAAGATCATTGAACTG
TATAAATTAAGTCAAAGAACTCCTATTAAAAACAAACAGGTAATATATGCACATCGTAGAATTGTAGGTAAGCAAAAAGGAGAAGGTTGA
TCATGCTTTGCTGTATGTCTTCGTAGACTTTCTCAGTCCACTCTCAGTACACGTTTTATTTTACTTGCTCATCCTGATTATACTGTTTTT
ACCCTCCACTTAAGTCATTTTTTGAATTTAAATGGTGAATATCTTTCTGTGTCAAATATTTCAACATTAATATGTACATAGTATTAAATG
GATTTACTATAAATTATTTAGCCTATTCTTACTGGCCACAGTAGTCTAACTAGATCTTTATACATTTGTATTTTTCTAGAATAAACTCAA
AAATGTGTAAGATCAAAGGGTATATATTGTGTTGCCAAGAAAAAGTTTGTGCCAATGTATATTTTTGCCAGGAGTCTTTCATAGTACCAT
TTATATCCTTCCCAGCATTAGCTGTGTTCTACCTTCTCTCCTCTTTGCCATTTTTACAAGAAAACCGGGCATGTCTAAAGTTTTCTTTTC
CTTTTTTTTTTTTTTTTTTTTTTTTTGGAGAGTCTCACTGGAATGCAGTGGCATGATCTTGGCTCCCTGCAACCTCCAGTCAGGCTGGTG
TGCCTTGTCGCGATATCAACGCGACCTCCGCCTCCCAGGTTCAAGTGATTGTCCTGCCTCACCCTCCTGAGTAGCTGGGATTACAGGTGG
GCGCCACCACTCCCATCTAATTTTTATATTTTTAGAGAGATGGGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTAGT
GATCCACCTGCCTCAGCCTCCCAAAGTGCCGGTATTAAAGGCATGAGCCACCAGGCCTGGCCTAAAATTTTCTTGATTAATTTTGATCTC
ATTTGTATTTTGTAAATGACTTATCTGTTGAGGCTTTTGCCATTGAGATGTTTGTCTTTTTCTTACTAATTTGTAAGAATTCTTGATGGG
TTTCTGTTAGTCATGTATTTTGCTAATAATTTCCCTAGTTTGTAGTTTGCCACTTAGTGCTATTTTTGACATAAATGATGTATTTTAATG
TAGTTGCATGTTGACCTAGTCCATTATGGTTTTTGTATTTGGTCCACGTGGATTGGAAAACCTTTGCTTTGATTATACTTTTCTTTGGGC

>In-frame_ENST00000348108_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(amino acids)=123AA_start in transcript=46_stop in transcript=417
MQCDFTEDQTAGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFE

--------------------------------------------------------------
>In-frame_ENST00000536128_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(transcript)=2610nt_BP=458nt
ATTACTGCAGGAAAAGGTCCCGGAGAGCTGAGCAGTCAAGATGGTGGGGCCCAGGTCTTGGGAGACGGGCAGGATTGGGGACGAGAGGCA
GGAAGAGACGGGTGGGGGGCGAGGAGAAGGCAGGGGTAGGAGGCAAAGGGAATCTGAGGACCCGAAAGGTTGGAGGTGGGGTTGGAAAGA
CTGGGGCCCTGCGGGGAAGCGAGTCTGCAGCCTGAAACAGGAGTTTGTGGGTCAGAGTTTGTGGGTCAGAGTTTGTGGGGCTGGGATAGA
AACTCGGGGGATTGGCGTTCAGATGCTGACCACTTCCCTCTTCTCTGAGCAGTGTGACTTCACCGAAGACCAGACCGCAGGTGATGGCAA
GATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAA
GAGTGATGAGCTTGTGGACAAATGTATAGGATCAAGAATTCACATCGTGATGAAGAGTGATAAGGAAATTGTTGGTACTCTTCTAGGATT
TGATGACTTTGTCAATATGGTACTGGAAGATGTCACTGAGTTTGAAATCACACCAGAAGGAAGAAGGATTACTAAATTAGATCAGATTTT
GCTAAATGGAAATAATATAACAATGCTGGTTCCTGGAGGAGAAGGACCTGAAGTGTGAATGAGTTTCCTTGACTTACACTAGATTTTGTT
TTGGCTTATAATGACAAGAAAATGGAATTTTTTTTCCCACTTTCTAATGTTTAAATCCCATAAAGCTAAGTTTCCCGTTAAAGGGAAGTG
CTTTGAAGATGTGTACCCATTTTTGTAAGTTAATCATGATTATCCTGGAAAAAGAAGAAAAGAGCTTCTTCTTTGCAGATGAAAATAAAG
GTGTTTTTGGTTAACTGTCATTTTGTTTATTCTACTGCAGTAGCCAGTGGAACAAAGTTTGTAGTTATTTTGCCACTTACTTTTCTGTCA
TTATATGCTTATTTGTTTTGTCATTTACGTGACCATTTGATTCTCAAACAAAAGTTGTTCCAAACAAAATGATGAACTTTGATTTGAACA
GGTGCATTTAAACAACCGGAAATGATCACTTAGAAAATTCAATTAAAATGCTGTTGTTTTGTAATGAGGATTTTTCTTCTGATTTCAAAT
TCCATGAACTCCTATTGAAAACAAACAATGTACAGGTAATATATGCACATTGTAGAAATGCAGGAATTATCTATTGGAATTACCCTAAAG
ATAGAAATTTTATCTATTTGCTTATAAAATTGATTCAGAAGGTTATTACCTTAATGTAGTTATTACTGAATTGCCAGGAAATGAGTGGAG
ACAGAGCTTTAAGATAAAGGATACTAAAAGCAGCTAAGAACTCCAGGACTCAGGTCAAATCAAGGAACTGATAATAAGATCATTGAACTG
TATAAATTAAGTCAAAGAACTCCTATTAAAAACAAACAGGTAATATATGCACATCGTAGAATTGTAGGTAAGCAAAAAGGAGAAGGTTGA
TCATGCTTTGCTGTATGTCTTCGTAGACTTTCTCAGTCCACTCTCAGTACACGTTTTATTTTACTTGCTCATCCTGATTATACTGTTTTT
ACCCTCCACTTAAGTCATTTTTTGAATTTAAATGGTGAATATCTTTCTGTGTCAAATATTTCAACATTAATATGTACATAGTATTAAATG
GATTTACTATAAATTATTTAGCCTATTCTTACTGGCCACAGTAGTCTAACTAGATCTTTATACATTTGTATTTTTCTAGAATAAACTCAA
AAATGTGTAAGATCAAAGGGTATATATTGTGTTGCCAAGAAAAAGTTTGTGCCAATGTATATTTTTGCCAGGAGTCTTTCATAGTACCAT
TTATATCCTTCCCAGCATTAGCTGTGTTCTACCTTCTCTCCTCTTTGCCATTTTTACAAGAAAACCGGGCATGTCTAAAGTTTTCTTTTC
CTTTTTTTTTTTTTTTTTTTTTTTTTGGAGAGTCTCACTGGAATGCAGTGGCATGATCTTGGCTCCCTGCAACCTCCAGTCAGGCTGGTG
TGCCTTGTCGCGATATCAACGCGACCTCCGCCTCCCAGGTTCAAGTGATTGTCCTGCCTCACCCTCCTGAGTAGCTGGGATTACAGGTGG
GCGCCACCACTCCCATCTAATTTTTATATTTTTAGAGAGATGGGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTAGT
GATCCACCTGCCTCAGCCTCCCAAAGTGCCGGTATTAAAGGCATGAGCCACCAGGCCTGGCCTAAAATTTTCTTGATTAATTTTGATCTC
ATTTGTATTTTGTAAATGACTTATCTGTTGAGGCTTTTGCCATTGAGATGTTTGTCTTTTTCTTACTAATTTGTAAGAATTCTTGATGGG
TTTCTGTTAGTCATGTATTTTGCTAATAATTTCCCTAGTTTGTAGTTTGCCACTTAGTGCTATTTTTGACATAAATGATGTATTTTAATG
TAGTTGCATGTTGACCTAGTCCATTATGGTTTTTGTATTTGGTCCACGTGGATTGGAAAACCTTTGCTTTGATTATACTTTTCTTTGGGC

>In-frame_ENST00000536128_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(amino acids)=215AA_start in transcript=40_stop in transcript=687
MVGPRSWETGRIGDERQEETGGGRGEGRGRRQRESEDPKGWRWGWKDWGPAGKRVCSLKQEFVGQSLWVRVCGAGIETRGIGVQMLTTSL
FSEQCDFTEDQTAGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTE

--------------------------------------------------------------
>In-frame_ENST00000547649_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(transcript)=2331nt_BP=179nt
ATTACTGCAGGAAAAGGTCCCGGAGAGCTGAGCAGTCAAGATGTGTGACTTCACCGAAGACCAGACCGCAGGTGATGGCAAGATCCTGTA
CAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAAGAGTGATGA
GCTTGTGGACAAATGTATAGGATCAAGAATTCACATCGTGATGAAGAGTGATAAGGAAATTGTTGGTACTCTTCTAGGATTTGATGACTT
TGTCAATATGGTACTGGAAGATGTCACTGAGTTTGAAATCACACCAGAAGGAAGAAGGATTACTAAATTAGATCAGATTTTGCTAAATGG
AAATAATATAACAATGCTGGTTCCTGGAGGAGAAGGACCTGAAGTGTGAATGAGTTTCCTTGACTTACACTAGATTTTGTTTTGGCTTAT
AATGACAAGAAAATGGAATTTTTTTTCCCACTTTCTAATGTTTAAATCCCATAAAGCTAAGTTTCCCGTTAAAGGGAAGTGCTTTGAAGA
TGTGTACCCATTTTTGTAAGTTAATCATGATTATCCTGGAAAAAGAAGAAAAGAGCTTCTTCTTTGCAGATGAAAATAAAGGTGTTTTTG
GTTAACTGTCATTTTGTTTATTCTACTGCAGTAGCCAGTGGAACAAAGTTTGTAGTTATTTTGCCACTTACTTTTCTGTCATTATATGCT
TATTTGTTTTGTCATTTACGTGACCATTTGATTCTCAAACAAAAGTTGTTCCAAACAAAATGATGAACTTTGATTTGAACAGGTGCATTT
AAACAACCGGAAATGATCACTTAGAAAATTCAATTAAAATGCTGTTGTTTTGTAATGAGGATTTTTCTTCTGATTTCAAATTCCATGAAC
TCCTATTGAAAACAAACAATGTACAGGTAATATATGCACATTGTAGAAATGCAGGAATTATCTATTGGAATTACCCTAAAGATAGAAATT
TTATCTATTTGCTTATAAAATTGATTCAGAAGGTTATTACCTTAATGTAGTTATTACTGAATTGCCAGGAAATGAGTGGAGACAGAGCTT
TAAGATAAAGGATACTAAAAGCAGCTAAGAACTCCAGGACTCAGGTCAAATCAAGGAACTGATAATAAGATCATTGAACTGTATAAATTA
AGTCAAAGAACTCCTATTAAAAACAAACAGGTAATATATGCACATCGTAGAATTGTAGGTAAGCAAAAAGGAGAAGGTTGATCATGCTTT
GCTGTATGTCTTCGTAGACTTTCTCAGTCCACTCTCAGTACACGTTTTATTTTACTTGCTCATCCTGATTATACTGTTTTTACCCTCCAC
TTAAGTCATTTTTTGAATTTAAATGGTGAATATCTTTCTGTGTCAAATATTTCAACATTAATATGTACATAGTATTAAATGGATTTACTA
TAAATTATTTAGCCTATTCTTACTGGCCACAGTAGTCTAACTAGATCTTTATACATTTGTATTTTTCTAGAATAAACTCAAAAATGTGTA
AGATCAAAGGGTATATATTGTGTTGCCAAGAAAAAGTTTGTGCCAATGTATATTTTTGCCAGGAGTCTTTCATAGTACCATTTATATCCT
TCCCAGCATTAGCTGTGTTCTACCTTCTCTCCTCTTTGCCATTTTTACAAGAAAACCGGGCATGTCTAAAGTTTTCTTTTCCTTTTTTTT
TTTTTTTTTTTTTTTTTGGAGAGTCTCACTGGAATGCAGTGGCATGATCTTGGCTCCCTGCAACCTCCAGTCAGGCTGGTGTGCCTTGTC
GCGATATCAACGCGACCTCCGCCTCCCAGGTTCAAGTGATTGTCCTGCCTCACCCTCCTGAGTAGCTGGGATTACAGGTGGGCGCCACCA
CTCCCATCTAATTTTTATATTTTTAGAGAGATGGGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTAGTGATCCACCT
GCCTCAGCCTCCCAAAGTGCCGGTATTAAAGGCATGAGCCACCAGGCCTGGCCTAAAATTTTCTTGATTAATTTTGATCTCATTTGTATT
TTGTAAATGACTTATCTGTTGAGGCTTTTGCCATTGAGATGTTTGTCTTTTTCTTACTAATTTGTAAGAATTCTTGATGGGTTTCTGTTA
GTCATGTATTTTGCTAATAATTTCCCTAGTTTGTAGTTTGCCACTTAGTGCTATTTTTGACATAAATGATGTATTTTAATGTAGTTGCAT

>In-frame_ENST00000547649_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(amino acids)=122AA_start in transcript=40_stop in transcript=408
MCDFTEDQTAGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEI

--------------------------------------------------------------
>In-frame_ENST00000547408_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(transcript)=2325nt_BP=173nt
GCAGGAAAAGGTCCCGGAGAGCTGAGCAGTCAAGATGTGTGACTTCACCGAAGACCAGACCGCAGGTGATGGCAAGATCCTGTACAGCCA
GTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAAGAGTGATGAGCTTGT
GGACAAATGTATAGGATCAAGAATTCACATCGTGATGAAGAGTGATAAGGAAATTGTTGGTACTCTTCTAGGATTTGATGACTTTGTCAA
TATGGTACTGGAAGATGTCACTGAGTTTGAAATCACACCAGAAGGAAGAAGGATTACTAAATTAGATCAGATTTTGCTAAATGGAAATAA
TATAACAATGCTGGTTCCTGGAGGAGAAGGACCTGAAGTGTGAATGAGTTTCCTTGACTTACACTAGATTTTGTTTTGGCTTATAATGAC
AAGAAAATGGAATTTTTTTTCCCACTTTCTAATGTTTAAATCCCATAAAGCTAAGTTTCCCGTTAAAGGGAAGTGCTTTGAAGATGTGTA
CCCATTTTTGTAAGTTAATCATGATTATCCTGGAAAAAGAAGAAAAGAGCTTCTTCTTTGCAGATGAAAATAAAGGTGTTTTTGGTTAAC
TGTCATTTTGTTTATTCTACTGCAGTAGCCAGTGGAACAAAGTTTGTAGTTATTTTGCCACTTACTTTTCTGTCATTATATGCTTATTTG
TTTTGTCATTTACGTGACCATTTGATTCTCAAACAAAAGTTGTTCCAAACAAAATGATGAACTTTGATTTGAACAGGTGCATTTAAACAA
CCGGAAATGATCACTTAGAAAATTCAATTAAAATGCTGTTGTTTTGTAATGAGGATTTTTCTTCTGATTTCAAATTCCATGAACTCCTAT
TGAAAACAAACAATGTACAGGTAATATATGCACATTGTAGAAATGCAGGAATTATCTATTGGAATTACCCTAAAGATAGAAATTTTATCT
ATTTGCTTATAAAATTGATTCAGAAGGTTATTACCTTAATGTAGTTATTACTGAATTGCCAGGAAATGAGTGGAGACAGAGCTTTAAGAT
AAAGGATACTAAAAGCAGCTAAGAACTCCAGGACTCAGGTCAAATCAAGGAACTGATAATAAGATCATTGAACTGTATAAATTAAGTCAA
AGAACTCCTATTAAAAACAAACAGGTAATATATGCACATCGTAGAATTGTAGGTAAGCAAAAAGGAGAAGGTTGATCATGCTTTGCTGTA
TGTCTTCGTAGACTTTCTCAGTCCACTCTCAGTACACGTTTTATTTTACTTGCTCATCCTGATTATACTGTTTTTACCCTCCACTTAAGT
CATTTTTTGAATTTAAATGGTGAATATCTTTCTGTGTCAAATATTTCAACATTAATATGTACATAGTATTAAATGGATTTACTATAAATT
ATTTAGCCTATTCTTACTGGCCACAGTAGTCTAACTAGATCTTTATACATTTGTATTTTTCTAGAATAAACTCAAAAATGTGTAAGATCA
AAGGGTATATATTGTGTTGCCAAGAAAAAGTTTGTGCCAATGTATATTTTTGCCAGGAGTCTTTCATAGTACCATTTATATCCTTCCCAG
CATTAGCTGTGTTCTACCTTCTCTCCTCTTTGCCATTTTTACAAGAAAACCGGGCATGTCTAAAGTTTTCTTTTCCTTTTTTTTTTTTTT
TTTTTTTTTTTGGAGAGTCTCACTGGAATGCAGTGGCATGATCTTGGCTCCCTGCAACCTCCAGTCAGGCTGGTGTGCCTTGTCGCGATA
TCAACGCGACCTCCGCCTCCCAGGTTCAAGTGATTGTCCTGCCTCACCCTCCTGAGTAGCTGGGATTACAGGTGGGCGCCACCACTCCCA
TCTAATTTTTATATTTTTAGAGAGATGGGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTAGTGATCCACCTGCCTCA
GCCTCCCAAAGTGCCGGTATTAAAGGCATGAGCCACCAGGCCTGGCCTAAAATTTTCTTGATTAATTTTGATCTCATTTGTATTTTGTAA
ATGACTTATCTGTTGAGGCTTTTGCCATTGAGATGTTTGTCTTTTTCTTACTAATTTGTAAGAATTCTTGATGGGTTTCTGTTAGTCATG
TATTTTGCTAATAATTTCCCTAGTTTGTAGTTTGCCACTTAGTGCTATTTTTGACATAAATGATGTATTTTAATGTAGTTGCATGTTGAC

>In-frame_ENST00000547408_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(amino acids)=122AA_start in transcript=34_stop in transcript=402
MCDFTEDQTAGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEI

--------------------------------------------------------------
>In-frame_ENST00000551589_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(transcript)=2324nt_BP=172nt
CAGGAAAAGGTCCCGGAGAGCTGAGCAGTCAAGATGTGTGACTTCACCGAAGACCAGACCGCAGGTGATGGCAAGATCCTGTACAGCCAG
TGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAAGAGTGATGAGCTTGTG
GACAAATGTATAGGATCAAGAATTCACATCGTGATGAAGAGTGATAAGGAAATTGTTGGTACTCTTCTAGGATTTGATGACTTTGTCAAT
ATGGTACTGGAAGATGTCACTGAGTTTGAAATCACACCAGAAGGAAGAAGGATTACTAAATTAGATCAGATTTTGCTAAATGGAAATAAT
ATAACAATGCTGGTTCCTGGAGGAGAAGGACCTGAAGTGTGAATGAGTTTCCTTGACTTACACTAGATTTTGTTTTGGCTTATAATGACA
AGAAAATGGAATTTTTTTTCCCACTTTCTAATGTTTAAATCCCATAAAGCTAAGTTTCCCGTTAAAGGGAAGTGCTTTGAAGATGTGTAC
CCATTTTTGTAAGTTAATCATGATTATCCTGGAAAAAGAAGAAAAGAGCTTCTTCTTTGCAGATGAAAATAAAGGTGTTTTTGGTTAACT
GTCATTTTGTTTATTCTACTGCAGTAGCCAGTGGAACAAAGTTTGTAGTTATTTTGCCACTTACTTTTCTGTCATTATATGCTTATTTGT
TTTGTCATTTACGTGACCATTTGATTCTCAAACAAAAGTTGTTCCAAACAAAATGATGAACTTTGATTTGAACAGGTGCATTTAAACAAC
CGGAAATGATCACTTAGAAAATTCAATTAAAATGCTGTTGTTTTGTAATGAGGATTTTTCTTCTGATTTCAAATTCCATGAACTCCTATT
GAAAACAAACAATGTACAGGTAATATATGCACATTGTAGAAATGCAGGAATTATCTATTGGAATTACCCTAAAGATAGAAATTTTATCTA
TTTGCTTATAAAATTGATTCAGAAGGTTATTACCTTAATGTAGTTATTACTGAATTGCCAGGAAATGAGTGGAGACAGAGCTTTAAGATA
AAGGATACTAAAAGCAGCTAAGAACTCCAGGACTCAGGTCAAATCAAGGAACTGATAATAAGATCATTGAACTGTATAAATTAAGTCAAA
GAACTCCTATTAAAAACAAACAGGTAATATATGCACATCGTAGAATTGTAGGTAAGCAAAAAGGAGAAGGTTGATCATGCTTTGCTGTAT
GTCTTCGTAGACTTTCTCAGTCCACTCTCAGTACACGTTTTATTTTACTTGCTCATCCTGATTATACTGTTTTTACCCTCCACTTAAGTC
ATTTTTTGAATTTAAATGGTGAATATCTTTCTGTGTCAAATATTTCAACATTAATATGTACATAGTATTAAATGGATTTACTATAAATTA
TTTAGCCTATTCTTACTGGCCACAGTAGTCTAACTAGATCTTTATACATTTGTATTTTTCTAGAATAAACTCAAAAATGTGTAAGATCAA
AGGGTATATATTGTGTTGCCAAGAAAAAGTTTGTGCCAATGTATATTTTTGCCAGGAGTCTTTCATAGTACCATTTATATCCTTCCCAGC
ATTAGCTGTGTTCTACCTTCTCTCCTCTTTGCCATTTTTACAAGAAAACCGGGCATGTCTAAAGTTTTCTTTTCCTTTTTTTTTTTTTTT
TTTTTTTTTTGGAGAGTCTCACTGGAATGCAGTGGCATGATCTTGGCTCCCTGCAACCTCCAGTCAGGCTGGTGTGCCTTGTCGCGATAT
CAACGCGACCTCCGCCTCCCAGGTTCAAGTGATTGTCCTGCCTCACCCTCCTGAGTAGCTGGGATTACAGGTGGGCGCCACCACTCCCAT
CTAATTTTTATATTTTTAGAGAGATGGGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTAGTGATCCACCTGCCTCAG
CCTCCCAAAGTGCCGGTATTAAAGGCATGAGCCACCAGGCCTGGCCTAAAATTTTCTTGATTAATTTTGATCTCATTTGTATTTTGTAAA
TGACTTATCTGTTGAGGCTTTTGCCATTGAGATGTTTGTCTTTTTCTTACTAATTTGTAAGAATTCTTGATGGGTTTCTGTTAGTCATGT
ATTTTGCTAATAATTTCCCTAGTTTGTAGTTTGCCACTTAGTGCTATTTTTGACATAAATGATGTATTTTAATGTAGTTGCATGTTGACC

>In-frame_ENST00000551589_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(amino acids)=122AA_start in transcript=33_stop in transcript=401
MCDFTEDQTAGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEI

--------------------------------------------------------------
>In-frame_ENST00000548400_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(transcript)=2239nt_BP=87nt
CGGAGAGCTGAGCAGTCAAGATGTGTGACTTCACCGAAGACCAGACCGCAGAGTTCAAGGAGGCCTTCCAGCTGTTTGACCGAACAGAGC
TTGTGGACAAATGTATAGGATCAAGAATTCACATCGTGATGAAGAGTGATAAGGAAATTGTTGGTACTCTTCTAGGATTTGATGACTTTG
TCAATATGGTACTGGAAGATGTCACTGAGTTTGAAATCACACCAGAAGGAAGAAGGATTACTAAATTAGATCAGATTTTGCTAAATGGAA
ATAATATAACAATGCTGGTTCCTGGAGGAGAAGGACCTGAAGTGTGAATGAGTTTCCTTGACTTACACTAGATTTTGTTTTGGCTTATAA
TGACAAGAAAATGGAATTTTTTTTCCCACTTTCTAATGTTTAAATCCCATAAAGCTAAGTTTCCCGTTAAAGGGAAGTGCTTTGAAGATG
TGTACCCATTTTTGTAAGTTAATCATGATTATCCTGGAAAAAGAAGAAAAGAGCTTCTTCTTTGCAGATGAAAATAAAGGTGTTTTTGGT
TAACTGTCATTTTGTTTATTCTACTGCAGTAGCCAGTGGAACAAAGTTTGTAGTTATTTTGCCACTTACTTTTCTGTCATTATATGCTTA
TTTGTTTTGTCATTTACGTGACCATTTGATTCTCAAACAAAAGTTGTTCCAAACAAAATGATGAACTTTGATTTGAACAGGTGCATTTAA
ACAACCGGAAATGATCACTTAGAAAATTCAATTAAAATGCTGTTGTTTTGTAATGAGGATTTTTCTTCTGATTTCAAATTCCATGAACTC
CTATTGAAAACAAACAATGTACAGGTAATATATGCACATTGTAGAAATGCAGGAATTATCTATTGGAATTACCCTAAAGATAGAAATTTT
ATCTATTTGCTTATAAAATTGATTCAGAAGGTTATTACCTTAATGTAGTTATTACTGAATTGCCAGGAAATGAGTGGAGACAGAGCTTTA
AGATAAAGGATACTAAAAGCAGCTAAGAACTCCAGGACTCAGGTCAAATCAAGGAACTGATAATAAGATCATTGAACTGTATAAATTAAG
TCAAAGAACTCCTATTAAAAACAAACAGGTAATATATGCACATCGTAGAATTGTAGGTAAGCAAAAAGGAGAAGGTTGATCATGCTTTGC
TGTATGTCTTCGTAGACTTTCTCAGTCCACTCTCAGTACACGTTTTATTTTACTTGCTCATCCTGATTATACTGTTTTTACCCTCCACTT
AAGTCATTTTTTGAATTTAAATGGTGAATATCTTTCTGTGTCAAATATTTCAACATTAATATGTACATAGTATTAAATGGATTTACTATA
AATTATTTAGCCTATTCTTACTGGCCACAGTAGTCTAACTAGATCTTTATACATTTGTATTTTTCTAGAATAAACTCAAAAATGTGTAAG
ATCAAAGGGTATATATTGTGTTGCCAAGAAAAAGTTTGTGCCAATGTATATTTTTGCCAGGAGTCTTTCATAGTACCATTTATATCCTTC
CCAGCATTAGCTGTGTTCTACCTTCTCTCCTCTTTGCCATTTTTACAAGAAAACCGGGCATGTCTAAAGTTTTCTTTTCCTTTTTTTTTT
TTTTTTTTTTTTTTTGGAGAGTCTCACTGGAATGCAGTGGCATGATCTTGGCTCCCTGCAACCTCCAGTCAGGCTGGTGTGCCTTGTCGC
GATATCAACGCGACCTCCGCCTCCCAGGTTCAAGTGATTGTCCTGCCTCACCCTCCTGAGTAGCTGGGATTACAGGTGGGCGCCACCACT
CCCATCTAATTTTTATATTTTTAGAGAGATGGGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTAGTGATCCACCTGC
CTCAGCCTCCCAAAGTGCCGGTATTAAAGGCATGAGCCACCAGGCCTGGCCTAAAATTTTCTTGATTAATTTTGATCTCATTTGTATTTT
GTAAATGACTTATCTGTTGAGGCTTTTGCCATTGAGATGTTTGTCTTTTTCTTACTAATTTGTAAGAATTCTTGATGGGTTTCTGTTAGT
CATGTATTTTGCTAATAATTTCCCTAGTTTGTAGTTTGCCACTTAGTGCTATTTTTGACATAAATGATGTATTTTAATGTAGTTGCATGT

>In-frame_ENST00000548400_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(amino acids)=102AA_start in transcript=1460_stop in transcript=1768
MPRKSLCQCIFLPGVFHSTIYILPSISCVLPSLLFAIFTRKPGMSKVFFSFFFFFFFFWRVSLECSGMILAPCNLQSGWCALSRYQRDLR

--------------------------------------------------------------
>In-frame_ENST00000548293_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(transcript)=2297nt_BP=145nt
GTCAAGATGTGTGACTTCACCGAAGACCAGACCGCAGGTGATGGCAAGATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGC
CAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAAGAGTGATGAGCTTGTGGACAAATGTATAGGATCAAGAATTCAC
ATCGTGATGAAGAGTGATAAGGAAATTGTTGGTACTCTTCTAGGATTTGATGACTTTGTCAATATGGTACTGGAAGATGTCACTGAGTTT
GAAATCACACCAGAAGGAAGAAGGATTACTAAATTAGATCAGATTTTGCTAAATGGAAATAATATAACAATGCTGGTTCCTGGAGGAGAA
GGACCTGAAGTGTGAATGAGTTTCCTTGACTTACACTAGATTTTGTTTTGGCTTATAATGACAAGAAAATGGAATTTTTTTTCCCACTTT
CTAATGTTTAAATCCCATAAAGCTAAGTTTCCCGTTAAAGGGAAGTGCTTTGAAGATGTGTACCCATTTTTGTAAGTTAATCATGATTAT
CCTGGAAAAAGAAGAAAAGAGCTTCTTCTTTGCAGATGAAAATAAAGGTGTTTTTGGTTAACTGTCATTTTGTTTATTCTACTGCAGTAG
CCAGTGGAACAAAGTTTGTAGTTATTTTGCCACTTACTTTTCTGTCATTATATGCTTATTTGTTTTGTCATTTACGTGACCATTTGATTC
TCAAACAAAAGTTGTTCCAAACAAAATGATGAACTTTGATTTGAACAGGTGCATTTAAACAACCGGAAATGATCACTTAGAAAATTCAAT
TAAAATGCTGTTGTTTTGTAATGAGGATTTTTCTTCTGATTTCAAATTCCATGAACTCCTATTGAAAACAAACAATGTACAGGTAATATA
TGCACATTGTAGAAATGCAGGAATTATCTATTGGAATTACCCTAAAGATAGAAATTTTATCTATTTGCTTATAAAATTGATTCAGAAGGT
TATTACCTTAATGTAGTTATTACTGAATTGCCAGGAAATGAGTGGAGACAGAGCTTTAAGATAAAGGATACTAAAAGCAGCTAAGAACTC
CAGGACTCAGGTCAAATCAAGGAACTGATAATAAGATCATTGAACTGTATAAATTAAGTCAAAGAACTCCTATTAAAAACAAACAGGTAA
TATATGCACATCGTAGAATTGTAGGTAAGCAAAAAGGAGAAGGTTGATCATGCTTTGCTGTATGTCTTCGTAGACTTTCTCAGTCCACTC
TCAGTACACGTTTTATTTTACTTGCTCATCCTGATTATACTGTTTTTACCCTCCACTTAAGTCATTTTTTGAATTTAAATGGTGAATATC
TTTCTGTGTCAAATATTTCAACATTAATATGTACATAGTATTAAATGGATTTACTATAAATTATTTAGCCTATTCTTACTGGCCACAGTA
GTCTAACTAGATCTTTATACATTTGTATTTTTCTAGAATAAACTCAAAAATGTGTAAGATCAAAGGGTATATATTGTGTTGCCAAGAAAA
AGTTTGTGCCAATGTATATTTTTGCCAGGAGTCTTTCATAGTACCATTTATATCCTTCCCAGCATTAGCTGTGTTCTACCTTCTCTCCTC
TTTGCCATTTTTACAAGAAAACCGGGCATGTCTAAAGTTTTCTTTTCCTTTTTTTTTTTTTTTTTTTTTTTTTGGAGAGTCTCACTGGAA
TGCAGTGGCATGATCTTGGCTCCCTGCAACCTCCAGTCAGGCTGGTGTGCCTTGTCGCGATATCAACGCGACCTCCGCCTCCCAGGTTCA
AGTGATTGTCCTGCCTCACCCTCCTGAGTAGCTGGGATTACAGGTGGGCGCCACCACTCCCATCTAATTTTTATATTTTTAGAGAGATGG
GGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCTAGTGATCCACCTGCCTCAGCCTCCCAAAGTGCCGGTATTAAAGGCA
TGAGCCACCAGGCCTGGCCTAAAATTTTCTTGATTAATTTTGATCTCATTTGTATTTTGTAAATGACTTATCTGTTGAGGCTTTTGCCAT
TGAGATGTTTGTCTTTTTCTTACTAATTTGTAAGAATTCTTGATGGGTTTCTGTTAGTCATGTATTTTGCTAATAATTTCCCTAGTTTGT
AGTTTGCCACTTAGTGCTATTTTTGACATAAATGATGTATTTTAATGTAGTTGCATGTTGACCTAGTCCATTATGGTTTTTGTATTTGGT

>In-frame_ENST00000548293_ENST00000450169_TCGA-CD-5799-01A_MYL6_chr12_56553406_+_LSM5_chr7_32528956_length(amino acids)=122AA_start in transcript=6_stop in transcript=374
MCDFTEDQTAGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MYL6-LSM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYL6-LSM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYL6-LSM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLSM5C0032460Polycystic Ovary Syndrome1CTD_human
TgeneLSM5C1136382Sclerocystic Ovaries1CTD_human