FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MYL6-MYL6B (FusionGDB2 ID:56134)

Fusion Gene Summary for MYL6-MYL6B

check button Fusion gene summary
Fusion gene informationFusion gene name: MYL6-MYL6B
Fusion gene ID: 56134
HgeneTgene
Gene symbol

MYL6

MYL6B

Gene ID

4637

140465

Gene namemyosin light chain 6myosin light chain 6B
SynonymsESMLC|LC17|LC17-GI|LC17-NM|LC17A|LC17B|MLC-3|MLC1SM|MLC3NM|MLC3SMMLC1SA
Cytomap

12q13.2

12q13.2

Type of geneprotein-codingprotein-coding
Descriptionmyosin light polypeptide 617 kDa myosin light chainmyosin light chain A3myosin light chain alkali 3myosin, light chain 6, alkali, smooth muscle and non-musclemyosin, light polypeptide 6, alkali, smooth muscle and non-musclemyosin light chain 6Bmyosin alkali light chain 1 slow amyosin light chain 1 slow amyosin light chain 1, slow-twitch muscle A isoformmyosin, light chain 6B, alkali, smooth muscle and non-musclemyosin, light polypeptide 6B, alkali, smooth muscle and no
Modification date2020031320200313
UniProtAcc.

P14649

Ensembl transtripts involved in fusion geneENST00000550697, ENST00000548580, 
ENST00000293422, ENST00000348108, 
ENST00000549017, ENST00000549566, 
ENST00000536128, ENST00000547649, 
ENST00000547408, ENST00000551589, 
ENST00000548400, ENST00000548293, 
ENST00000551954, 		ENST00000553066, 
ENST00000550443, ENST00000207437, 
ENST00000552568, ENST00000550152, 
Fusion gene scores* DoF score34 X 17 X 10=57804 X 5 X 3=60
# samples 364
** MAII scorelog2(36/5780*10)=-4.00500068105837
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYL6 [Title/Abstract] AND MYL6B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYL6(56553465)-MYL6B(56548933), # samples:1
MYL6(56553759)-MYL6B(56548982), # samples:1
MYL6B(56551774)-MYL6(56552157), # samples:1
MYL6B(56548982)-MYL6(56553759), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MYL6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MYL6B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA167303MYL6chr12

56553465

-MYL6Bchr12

56548933

-
ChiTaRS5.0N/AAA507315MYL6chr12

56553759

-MYL6Bchr12

56548982

-


Top

Fusion Gene ORF analysis for MYL6-MYL6B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000550697ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000550697ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000550697ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000550697ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
5CDS-3UTRENST00000550697ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000548580ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000548580ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000548580ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000548580ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3UTRENST00000548580ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000293422ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000293422ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000293422ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000293422ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
5CDS-3UTRENST00000293422ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000348108ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000348108ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000348108ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000348108ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
5CDS-3UTRENST00000348108ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000549017ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000549017ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000549017ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000549017ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3UTRENST00000549017ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000549566ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000549566ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000549566ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000549566ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3UTRENST00000549566ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000536128ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000536128ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000536128ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000536128ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
5CDS-3UTRENST00000536128ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000547649ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000547649ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000547649ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000547649ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
5CDS-3UTRENST00000547649ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000547408ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000547408ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000547408ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000547408ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
5CDS-3UTRENST00000547408ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000551589ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000551589ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000551589ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000551589ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
5CDS-3UTRENST00000551589ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000548400ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000548400ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000548400ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000548400ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3UTRENST00000548400ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000548293ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000548293ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000548293ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
In-frameENST00000548293ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
5CDS-3UTRENST00000548293ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000551954ENST00000553066MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000551954ENST00000550443MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000551954ENST00000207437MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3CDSENST00000551954ENST00000552568MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-3UTRENST00000551954ENST00000550152MYL6chr12

56553465

-MYL6Bchr12

56548933

-
intron-intronENST00000550697ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000550697ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000550697ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000550697ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000550697ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548580ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548580ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548580ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548580ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548580ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000293422ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000293422ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000293422ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000293422ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000293422ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000348108ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000348108ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000348108ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000348108ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000348108ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000549017ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000549017ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000549017ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000549017ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000549017ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000549566ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000549566ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000549566ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000549566ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000549566ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000536128ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000536128ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000536128ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000536128ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000536128ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000547649ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000547649ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000547649ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000547649ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000547649ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000547408ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000547408ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000547408ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000547408ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000547408ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000551589ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000551589ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000551589ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000551589ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000551589ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548400ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548400ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548400ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548400ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548400ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548293ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548293ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548293ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548293ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000548293ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000551954ENST00000553066MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000551954ENST00000550443MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000551954ENST00000207437MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000551954ENST00000552568MYL6chr12

56553759

-MYL6Bchr12

56548982

-
intron-intronENST00000551954ENST00000550152MYL6chr12

56553759

-MYL6Bchr12

56548982

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MYL6-MYL6B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MYL6-MYL6B


check button Go to

FGviewer for the breakpoints of chr12:56553465-chr12:56548933

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYL6B

P14649

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Regulatory light chain of myosin. Does not bind calcium.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYL6Bchr12:56553465chr12:56548933ENST0000020743708141_1760217.33333333333334DomainEF-hand 2
TgeneMYL6Bchr12:56553465chr12:56548933ENST0000020743708176_2080217.33333333333334DomainEF-hand 3
TgeneMYL6Bchr12:56553465chr12:56548933ENST000002074370864_990217.33333333333334DomainEF-hand 1
TgeneMYL6Bchr12:56553465chr12:56548933ENST0000055044308141_1760176.33333333333334DomainEF-hand 2
TgeneMYL6Bchr12:56553465chr12:56548933ENST0000055044308176_2080176.33333333333334DomainEF-hand 3
TgeneMYL6Bchr12:56553465chr12:56548933ENST000005504430864_990176.33333333333334DomainEF-hand 1
TgeneMYL6Bchr12:56553465chr12:56548933ENST0000055306607141_1760209.0DomainEF-hand 2
TgeneMYL6Bchr12:56553465chr12:56548933ENST0000055306607176_2080209.0DomainEF-hand 3
TgeneMYL6Bchr12:56553465chr12:56548933ENST000005530660764_990209.0DomainEF-hand 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYL6chr12:56553465chr12:56548933ENST00000547649-16119_1510152.0DomainEF-hand 3
HgeneMYL6chr12:56553465chr12:56548933ENST00000547649-167_420152.0DomainEF-hand 1
HgeneMYL6chr12:56553465chr12:56548933ENST00000547649-1684_1190152.0DomainEF-hand 2
HgeneMYL6chr12:56553465chr12:56548933ENST00000548293-16119_1510152.0DomainEF-hand 3
HgeneMYL6chr12:56553465chr12:56548933ENST00000548293-167_420152.0DomainEF-hand 1
HgeneMYL6chr12:56553465chr12:56548933ENST00000548293-1684_1190152.0DomainEF-hand 2
HgeneMYL6chr12:56553465chr12:56548933ENST00000550697-17119_1510133.33333333333334DomainEF-hand 3
HgeneMYL6chr12:56553465chr12:56548933ENST00000550697-177_420133.33333333333334DomainEF-hand 1
HgeneMYL6chr12:56553465chr12:56548933ENST00000550697-1784_1190133.33333333333334DomainEF-hand 2


Top

Fusion Gene Sequence for MYL6-MYL6B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MYL6-MYL6B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MYL6-MYL6B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MYL6-MYL6B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYL6BC0022548Keloid1CTD_human