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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MYO10-C5orf38 (FusionGDB2 ID:56202)

Fusion Gene Summary for MYO10-C5orf38

Fusion gene summary

Fusion gene information	Fusion gene name: MYO10-C5orf38
	Fusion gene ID: 56202
		Hgene	Tgene
	Gene symbol	MYO10	C5orf38
	Gene ID	4651	153571
	Gene name	myosin X	chromosome 5 open reading frame 38
	Synonyms	-	CEI\|IRX2NB
	Cytomap	5p15.1	5p15.33
	Type of gene	protein-coding	protein-coding
	Description	unconventional myosin-Xunconventional myosin-10unconventionnal myosin-X	protein CEIIRX2 neighborcoordinated expression to IRX2coordinated expression to IRXA2 homeoboxcoordinated expression to IRXA2 protein
	Modification date	20200313	20200320
	UniProtAcc	Q9HD67	.
	Ensembl transtripts involved in fusion gene	ENST00000513610, ENST00000507288, ENST00000274203, ENST00000515803, ENST00000427430, ENST00000505695, ENST00000512061,	ENST00000457752, ENST00000334000, ENST00000505778, ENST00000515640, ENST00000397835,
Fusion gene scores	* DoF score	20 X 14 X 10=2800	3 X 3 X 3=27
	# samples	25	5
	** MAII score	log2(25/2800*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/27*10)=0.888968687611256 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: MYO10 [Title/Abstract] AND C5orf38 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MYO10(16877718)-C5orf38(2755143), # samples:3
Anticipated loss of major functional domain due to fusion event.	MYO10-C5orf38 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MYO10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C5orf38 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-D3-A2JC-06A	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
ChimerDB4	SKCM	TCGA-D3-A2JC	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
ChimerDB4	SKCM	TCGA-D3-A2JC-06A	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
ChimerDB4	SKCM	TCGA-D3-A2JC-06A	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+

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Fusion Gene ORF analysis for MYO10-C5orf38

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000513610	ENST00000457752	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
Frame-shift	ENST00000513610	ENST00000334000	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
5CDS-3UTR	ENST00000513610	ENST00000505778	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
5CDS-intron	ENST00000513610	ENST00000515640	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
5CDS-intron	ENST00000513610	ENST00000397835	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
Frame-shift	ENST00000507288	ENST00000457752	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
Frame-shift	ENST00000507288	ENST00000334000	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
5CDS-3UTR	ENST00000507288	ENST00000505778	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
5CDS-intron	ENST00000507288	ENST00000515640	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
5CDS-intron	ENST00000507288	ENST00000397835	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3CDS	ENST00000274203	ENST00000457752	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3CDS	ENST00000274203	ENST00000334000	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3UTR	ENST00000274203	ENST00000505778	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-intron	ENST00000274203	ENST00000515640	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-intron	ENST00000274203	ENST00000397835	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3CDS	ENST00000515803	ENST00000457752	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3CDS	ENST00000515803	ENST00000334000	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3UTR	ENST00000515803	ENST00000505778	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-intron	ENST00000515803	ENST00000515640	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-intron	ENST00000515803	ENST00000397835	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3CDS	ENST00000427430	ENST00000457752	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3CDS	ENST00000427430	ENST00000334000	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3UTR	ENST00000427430	ENST00000505778	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-intron	ENST00000427430	ENST00000515640	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-intron	ENST00000427430	ENST00000397835	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3CDS	ENST00000505695	ENST00000457752	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3CDS	ENST00000505695	ENST00000334000	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3UTR	ENST00000505695	ENST00000505778	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-intron	ENST00000505695	ENST00000515640	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-intron	ENST00000505695	ENST00000397835	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3CDS	ENST00000512061	ENST00000457752	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3CDS	ENST00000512061	ENST00000334000	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-3UTR	ENST00000512061	ENST00000505778	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-intron	ENST00000512061	ENST00000515640	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
intron-intron	ENST00000512061	ENST00000397835	MYO10	chr5	16877718	-	C5orf38	chr5	2755143	+
Frame-shift	ENST00000513610	ENST00000457752	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
Frame-shift	ENST00000513610	ENST00000334000	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
5CDS-3UTR	ENST00000513610	ENST00000505778	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
5CDS-intron	ENST00000513610	ENST00000515640	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
5CDS-intron	ENST00000513610	ENST00000397835	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
Frame-shift	ENST00000507288	ENST00000457752	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
Frame-shift	ENST00000507288	ENST00000334000	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
5CDS-3UTR	ENST00000507288	ENST00000505778	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
5CDS-intron	ENST00000507288	ENST00000515640	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
5CDS-intron	ENST00000507288	ENST00000397835	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3CDS	ENST00000274203	ENST00000457752	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3CDS	ENST00000274203	ENST00000334000	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3UTR	ENST00000274203	ENST00000505778	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-intron	ENST00000274203	ENST00000515640	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-intron	ENST00000274203	ENST00000397835	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3CDS	ENST00000515803	ENST00000457752	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3CDS	ENST00000515803	ENST00000334000	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3UTR	ENST00000515803	ENST00000505778	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-intron	ENST00000515803	ENST00000515640	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-intron	ENST00000515803	ENST00000397835	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3CDS	ENST00000427430	ENST00000457752	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3CDS	ENST00000427430	ENST00000334000	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3UTR	ENST00000427430	ENST00000505778	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-intron	ENST00000427430	ENST00000515640	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-intron	ENST00000427430	ENST00000397835	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3CDS	ENST00000505695	ENST00000457752	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3CDS	ENST00000505695	ENST00000334000	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3UTR	ENST00000505695	ENST00000505778	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-intron	ENST00000505695	ENST00000515640	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-intron	ENST00000505695	ENST00000397835	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3CDS	ENST00000512061	ENST00000457752	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3CDS	ENST00000512061	ENST00000334000	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-3UTR	ENST00000512061	ENST00000505778	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-intron	ENST00000512061	ENST00000515640	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+
intron-intron	ENST00000512061	ENST00000397835	MYO10	chr5	16877717	-	C5orf38	chr5	2755142	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MYO10-C5orf38

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYO10-C5orf38

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MYO10 Q9HD67	.
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269\|PubMed:16894163, ECO:0000269\|PubMed:18570893}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MYO10-C5orf38

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MYO10-C5orf38

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MYO10-C5orf38

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MYO10-C5orf38

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MYO10	C0043094	Weight Gain	1	CTD_human