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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYO1B-SPAG16 (FusionGDB2 ID:56290)

Fusion Gene Summary for MYO1B-SPAG16

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO1B-SPAG16
Fusion gene ID: 56290
HgeneTgene
Gene symbol

MYO1B

SPAG16

Gene ID

4430

79582

Gene namemyosin IBsperm associated antigen 16
SynonymsMMI-alpha|MMIa|MYH-1c|myr1PF20|WDR29
Cytomap

2q32.3

2q34

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-IbMYO1B variant proteinmyosin-I alphasperm-associated antigen 16 proteinWD repeat domain 29pf20 protein homologsperm-associated WD repeat protein
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000339514, ENST00000392318, 
ENST00000304164, ENST00000392316, 
ENST00000439065, ENST00000496992, 
ENST00000331683, ENST00000374309, 
ENST00000432529, ENST00000413312, 
ENST00000272898, ENST00000447990, 
ENST00000414961, 
Fusion gene scores* DoF score13 X 10 X 6=78016 X 16 X 8=2048
# samples 1618
** MAII scorelog2(16/780*10)=-2.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2048*10)=-3.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO1B [Title/Abstract] AND SPAG16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYO1B(192141756)-SPAG16(215274864), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MYO1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SPAG16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-6499-01AMYO1Bchr2

192141756

+SPAG16chr2

215274864

+
ChimerDB4PRADTCGA-G9-6499-01AMYO1Bchr2

192141756

-SPAG16chr2

215274864

+


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Fusion Gene ORF analysis for MYO1B-SPAG16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000339514ENST00000331683MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
In-frameENST00000339514ENST00000374309MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000339514ENST00000432529MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000339514ENST00000413312MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000339514ENST00000272898MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000339514ENST00000447990MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000339514ENST00000414961MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
In-frameENST00000392318ENST00000331683MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
In-frameENST00000392318ENST00000374309MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000392318ENST00000432529MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000392318ENST00000413312MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000392318ENST00000272898MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000392318ENST00000447990MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000392318ENST00000414961MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
In-frameENST00000304164ENST00000331683MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
In-frameENST00000304164ENST00000374309MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000304164ENST00000432529MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000304164ENST00000413312MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000304164ENST00000272898MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000304164ENST00000447990MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000304164ENST00000414961MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
In-frameENST00000392316ENST00000331683MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
In-frameENST00000392316ENST00000374309MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000392316ENST00000432529MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000392316ENST00000413312MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000392316ENST00000272898MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000392316ENST00000447990MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
5CDS-intronENST00000392316ENST00000414961MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-3CDSENST00000439065ENST00000331683MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-3CDSENST00000439065ENST00000374309MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-intronENST00000439065ENST00000432529MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-intronENST00000439065ENST00000413312MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-intronENST00000439065ENST00000272898MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-intronENST00000439065ENST00000447990MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-intronENST00000439065ENST00000414961MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-3CDSENST00000496992ENST00000331683MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-3CDSENST00000496992ENST00000374309MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-intronENST00000496992ENST00000432529MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-intronENST00000496992ENST00000413312MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-intronENST00000496992ENST00000272898MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-intronENST00000496992ENST00000447990MYO1Bchr2

192141756

+SPAG16chr2

215274864

+
intron-intronENST00000496992ENST00000414961MYO1Bchr2

192141756

+SPAG16chr2

215274864

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339514MYO1Bchr2192141756+ENST00000331683SPAG16chr2215274864+8574954842161
ENST00000339514MYO1Bchr2192141756+ENST00000374309SPAG16chr2215274864+6714954842161
ENST00000392318MYO1Bchr2192141756+ENST00000331683SPAG16chr2215274864+74438213393126
ENST00000392318MYO1Bchr2192141756+ENST00000374309SPAG16chr2215274864+55838213393126
ENST00000304164MYO1Bchr2192141756+ENST00000331683SPAG16chr2215274864+590228217272
ENST00000304164MYO1Bchr2192141756+ENST00000374309SPAG16chr2215274864+404228217272
ENST00000392316MYO1Bchr2192141756+ENST00000331683SPAG16chr2215274864+50814645826165
ENST00000392316MYO1Bchr2192141756+ENST00000374309SPAG16chr2215274864+322146215751

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339514ENST00000331683MYO1Bchr2192141756+SPAG16chr2215274864+0.289752450.7102476
ENST00000339514ENST00000374309MYO1Bchr2192141756+SPAG16chr2215274864+0.192883570.80711645
ENST00000392318ENST00000331683MYO1Bchr2192141756+SPAG16chr2215274864+0.261744950.7382551
ENST00000392318ENST00000374309MYO1Bchr2192141756+SPAG16chr2215274864+0.1036108660.8963892
ENST00000304164ENST00000331683MYO1Bchr2192141756+SPAG16chr2215274864+0.16042710.8395729
ENST00000304164ENST00000374309MYO1Bchr2192141756+SPAG16chr2215274864+0.17839340.82160664
ENST00000392316ENST00000331683MYO1Bchr2192141756+SPAG16chr2215274864+0.326076950.6739231
ENST00000392316ENST00000374309MYO1Bchr2192141756+SPAG16chr2215274864+0.281634180.71836585

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Fusion Genomic Features for MYO1B-SPAG16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYO1B-SPAG16


check button Go to

FGviewer for the breakpoints of chr2:192141756-chr2:215274864

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPAG16chr2:192141756chr2:215274864ENST00000272898010152_2670348.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:192141756chr2:215274864ENST0000041331207152_2670252.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:192141756chr2:215274864ENST0000043252905152_2670184.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:192141756chr2:215274864ENST00000272898010350_3890348.0RepeatNote=WD 1
TgeneSPAG16chr2:192141756chr2:215274864ENST00000272898010392_4310348.0RepeatNote=WD 2
TgeneSPAG16chr2:192141756chr2:215274864ENST00000272898010434_4730348.0RepeatNote=WD 3
TgeneSPAG16chr2:192141756chr2:215274864ENST00000272898010476_5150348.0RepeatNote=WD 4
TgeneSPAG16chr2:192141756chr2:215274864ENST00000272898010518_5570348.0RepeatNote=WD 5
TgeneSPAG16chr2:192141756chr2:215274864ENST00000272898010560_6000348.0RepeatNote=WD 6
TgeneSPAG16chr2:192141756chr2:215274864ENST00000272898010601_6300348.0RepeatNote=WD 7
TgeneSPAG16chr2:192141756chr2:215274864ENST000003316831416601_630573.3333333333334632.0RepeatNote=WD 7
TgeneSPAG16chr2:192141756chr2:215274864ENST0000041331207350_3890252.0RepeatNote=WD 1
TgeneSPAG16chr2:192141756chr2:215274864ENST0000041331207392_4310252.0RepeatNote=WD 2
TgeneSPAG16chr2:192141756chr2:215274864ENST0000041331207434_4730252.0RepeatNote=WD 3
TgeneSPAG16chr2:192141756chr2:215274864ENST0000041331207476_5150252.0RepeatNote=WD 4
TgeneSPAG16chr2:192141756chr2:215274864ENST0000041331207518_5570252.0RepeatNote=WD 5
TgeneSPAG16chr2:192141756chr2:215274864ENST0000041331207560_6000252.0RepeatNote=WD 6
TgeneSPAG16chr2:192141756chr2:215274864ENST0000041331207601_6300252.0RepeatNote=WD 7
TgeneSPAG16chr2:192141756chr2:215274864ENST0000043252905350_3890184.0RepeatNote=WD 1
TgeneSPAG16chr2:192141756chr2:215274864ENST0000043252905392_4310184.0RepeatNote=WD 2
TgeneSPAG16chr2:192141756chr2:215274864ENST0000043252905434_4730184.0RepeatNote=WD 3
TgeneSPAG16chr2:192141756chr2:215274864ENST0000043252905476_5150184.0RepeatNote=WD 4
TgeneSPAG16chr2:192141756chr2:215274864ENST0000043252905518_5570184.0RepeatNote=WD 5
TgeneSPAG16chr2:192141756chr2:215274864ENST0000043252905560_6000184.0RepeatNote=WD 6
TgeneSPAG16chr2:192141756chr2:215274864ENST0000043252905601_6300184.0RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000304164+23115_70145.01137.0DomainMyosin motor
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000304164+231704_73345.01137.0DomainIQ 1
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000304164+231728_74845.01137.0DomainIQ 2
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000304164+231750_77945.01137.0DomainIQ 3
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000304164+231779_80845.01137.0DomainIQ 4
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000304164+231808_83745.01137.0DomainIQ 5
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000304164+231837_86645.01137.0DomainIQ 6
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000304164+231952_113645.01137.0DomainTH1
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000339514+22915_70145.01079.0DomainMyosin motor
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000339514+229704_73345.01079.0DomainIQ 1
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000339514+229728_74845.01079.0DomainIQ 2
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000339514+229750_77945.01079.0DomainIQ 3
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000339514+229779_80845.01079.0DomainIQ 4
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000339514+229808_83745.01079.0DomainIQ 5
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000339514+229837_86645.01079.0DomainIQ 6
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000339514+229952_113645.01079.0DomainTH1
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000392318+23115_70145.01137.0DomainMyosin motor
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000392318+231704_73345.01137.0DomainIQ 1
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000392318+231728_74845.01137.0DomainIQ 2
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000392318+231750_77945.01137.0DomainIQ 3
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000392318+231779_80845.01137.0DomainIQ 4
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000392318+231808_83745.01137.0DomainIQ 5
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000392318+231837_86645.01137.0DomainIQ 6
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000392318+231952_113645.01137.0DomainTH1
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000304164+231108_11545.01137.0Nucleotide bindingATP
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000339514+229108_11545.01079.0Nucleotide bindingATP
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000392318+231108_11545.01137.0Nucleotide bindingATP
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000304164+231578_60045.01137.0RegionActin-binding
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000339514+229578_60045.01079.0RegionActin-binding
HgeneMYO1Bchr2:192141756chr2:215274864ENST00000392318+231578_60045.01137.0RegionActin-binding
TgeneSPAG16chr2:192141756chr2:215274864ENST000003316831416152_267573.3333333333334632.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG16chr2:192141756chr2:215274864ENST000003316831416350_389573.3333333333334632.0RepeatNote=WD 1
TgeneSPAG16chr2:192141756chr2:215274864ENST000003316831416392_431573.3333333333334632.0RepeatNote=WD 2
TgeneSPAG16chr2:192141756chr2:215274864ENST000003316831416434_473573.3333333333334632.0RepeatNote=WD 3
TgeneSPAG16chr2:192141756chr2:215274864ENST000003316831416476_515573.3333333333334632.0RepeatNote=WD 4
TgeneSPAG16chr2:192141756chr2:215274864ENST000003316831416518_557573.3333333333334632.0RepeatNote=WD 5
TgeneSPAG16chr2:192141756chr2:215274864ENST000003316831416560_600573.3333333333334632.0RepeatNote=WD 6


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Fusion Gene Sequence for MYO1B-SPAG16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000339514_ENST00000331683_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(transcript)=857nt_BP=495nt
GGTGGCTCCCGTTCCTGCCCGCGCGCCGAGGGGCGAATCCCAGGCAGCGAGGTCGCCGCCCCCGCCCCTCGGCCGGCCCCTCCGCCAGCG
GGCGAGAGGGGAGTGGCCGGGCTCCTCCCGCCGCCGCTGAGCACTCCGCAGCTGGGTGCGCACGGGAGCCTCAACCGCGGCGCGTGGAGG
CAGTACCAGAGCGCGCGGCGCGCAGTCGGCCGGCAGCCGCGGGACAGCCTTGGCAGAACAGCCGCGGCGGGAGCCCCGCAGCCCCGGGCT
GGGCCCGCGTCCCGGAGCGCCACCGGAGAGCGAGGACGACGTGGAGGCGGAGTGGCGCCCGGCGAGGTAGCGCCAGGCGAGCTGGAGACC
ATGGCCAAAATGGAGGTGAAAACCTCACTTCTGGACAATATGATTGGAGTTGGGGATATGGTTCTTTTAGAACCTCTCAATGAGGAGACC
TTCATCAACAACCTCAAGAAGCGCTTTGACCACAGTGAAATATACGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCCATTTGC
TAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAGATTCTCT
TTTCTGGAGGCTCTGACGGCACAGTTCGAACGTGGTCTTGACCGTCAGCACATCCCGCTGCAGAGGGCATTCCCTTTAAGGCTTGAAAAT
GCCTCCTGTAGTCCCAAACCAGCAAAGAACTGGTTAAATGTGCCAGCAGGTAACATTTACAGTCTGCTTTAAAACATGCTTTGGACATAT

>In-frame_ENST00000339514_ENST00000331683_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(amino acids)=161AA_start in transcript=484_stop in transcript=2
MWSKRFLRLLMKVSSLRGSKRTISPTPIILSRSEVFTSILAMVSSSPGATSPGATPPPRRPRSPVALRDAGPARGCGAPAAAVLPRLSRG

--------------------------------------------------------------
>In-frame_ENST00000339514_ENST00000374309_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(transcript)=671nt_BP=495nt
GGTGGCTCCCGTTCCTGCCCGCGCGCCGAGGGGCGAATCCCAGGCAGCGAGGTCGCCGCCCCCGCCCCTCGGCCGGCCCCTCCGCCAGCG
GGCGAGAGGGGAGTGGCCGGGCTCCTCCCGCCGCCGCTGAGCACTCCGCAGCTGGGTGCGCACGGGAGCCTCAACCGCGGCGCGTGGAGG
CAGTACCAGAGCGCGCGGCGCGCAGTCGGCCGGCAGCCGCGGGACAGCCTTGGCAGAACAGCCGCGGCGGGAGCCCCGCAGCCCCGGGCT
GGGCCCGCGTCCCGGAGCGCCACCGGAGAGCGAGGACGACGTGGAGGCGGAGTGGCGCCCGGCGAGGTAGCGCCAGGCGAGCTGGAGACC
ATGGCCAAAATGGAGGTGAAAACCTCACTTCTGGACAATATGATTGGAGTTGGGGATATGGTTCTTTTAGAACCTCTCAATGAGGAGACC
TTCATCAACAACCTCAAGAAGCGCTTTGACCACAGTGAAATATACGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCCATTTGC
TAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAGATTCTCT

>In-frame_ENST00000339514_ENST00000374309_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(amino acids)=161AA_start in transcript=484_stop in transcript=2
MWSKRFLRLLMKVSSLRGSKRTISPTPIILSRSEVFTSILAMVSSSPGATSPGATPPPRRPRSPVALRDAGPARGCGAPAAAVLPRLSRG

--------------------------------------------------------------
>In-frame_ENST00000392318_ENST00000331683_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(transcript)=744nt_BP=382nt
CCTCCCGCCGCCGCTGAGCACTCCGCAGCTGGGTGCGCACGGGAGCCTCAACCGCGGCGCGTGGAGGCAGTACCAGAGCGCGCGGCGCGC
AGTCGGCCGGCAGCCGCGGGACAGCCTTGGCAGAACAGCCGCGGCGGGAGCCCCGCAGCCCCGGGCTGGGCCCGCGTCCCGGAGCGCCAC
CGGAGAGCGAGGACGACGTGGAGGCGGAGTGGCGCCCGGCGAGGTAGCGCCAGGCGAGCTGGAGACCATGGCCAAAATGGAGGTGAAAAC
CTCACTTCTGGACAATATGATTGGAGTTGGGGATATGGTTCTTTTAGAACCTCTCAATGAGGAGACCTTCATCAACAACCTCAAGAAGCG
CTTTGACCACAGTGAAATATACGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCCATTTGCTAGATCTTAAATCTGGGGAGATT
CACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAGATTCTCTTTTCTGGAGGCTCTGACGGCACA
GTTCGAACGTGGTCTTGACCGTCAGCACATCCCGCTGCAGAGGGCATTCCCTTTAAGGCTTGAAAATGCCTCCTGTAGTCCCAAACCAGC
AAAGAACTGGTTAAATGTGCCAGCAGGTAACATTTACAGTCTGCTTTAAAACATGCTTTGGACATATATTTTAGTGCTCATACTGTTACT

>In-frame_ENST00000392318_ENST00000331683_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(amino acids)=126AA_start in transcript=13_stop in transcript=393
MSTPQLGAHGSLNRGAWRQYQSARRAVGRQPRDSLGRTAAAGAPQPRAGPASRSATGERGRRGGGVAPGEVAPGELETMAKMEVKTSLLD

--------------------------------------------------------------
>In-frame_ENST00000392318_ENST00000374309_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(transcript)=558nt_BP=382nt
CCTCCCGCCGCCGCTGAGCACTCCGCAGCTGGGTGCGCACGGGAGCCTCAACCGCGGCGCGTGGAGGCAGTACCAGAGCGCGCGGCGCGC
AGTCGGCCGGCAGCCGCGGGACAGCCTTGGCAGAACAGCCGCGGCGGGAGCCCCGCAGCCCCGGGCTGGGCCCGCGTCCCGGAGCGCCAC
CGGAGAGCGAGGACGACGTGGAGGCGGAGTGGCGCCCGGCGAGGTAGCGCCAGGCGAGCTGGAGACCATGGCCAAAATGGAGGTGAAAAC
CTCACTTCTGGACAATATGATTGGAGTTGGGGATATGGTTCTTTTAGAACCTCTCAATGAGGAGACCTTCATCAACAACCTCAAGAAGCG
CTTTGACCACAGTGAAATATACGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCCATTTGCTAGATCTTAAATCTGGGGAGATT
CACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAGATTCTCTTTTCTGGAGGCTCTGACGGCACA

>In-frame_ENST00000392318_ENST00000374309_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(amino acids)=126AA_start in transcript=13_stop in transcript=393
MSTPQLGAHGSLNRGAWRQYQSARRAVGRQPRDSLGRTAAAGAPQPRAGPASRSATGERGRRGGGVAPGEVAPGELETMAKMEVKTSLLD

--------------------------------------------------------------
>In-frame_ENST00000304164_ENST00000331683_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(transcript)=590nt_BP=228nt
GCCCCGCAGCCCCGGGCTGGGCCCGCGTCCCGGAGCGCCACCGGAGAGCGAGGACGACGTGGAGGCGGAGTGGCGCCCGGCGAGCTGGAG
ACCATGGCCAAAATGGAGGTGAAAACCTCACTTCTGGACAATATGATTGGAGTTGGGGATATGGTTCTTTTAGAACCTCTCAATGAGGAG
ACCTTCATCAACAACCTCAAGAAGCGCTTTGACCACAGTGAAATATACGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCCATT
TGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAGATTC
TCTTTTCTGGAGGCTCTGACGGCACAGTTCGAACGTGGTCTTGACCGTCAGCACATCCCGCTGCAGAGGGCATTCCCTTTAAGGCTTGAA
AATGCCTCCTGTAGTCCCAAACCAGCAAAGAACTGGTTAAATGTGCCAGCAGGTAACATTTACAGTCTGCTTTAAAACATGCTTTGGACA

>In-frame_ENST00000304164_ENST00000331683_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(amino acids)=72AA_start in transcript=217_stop in transcript=2

--------------------------------------------------------------
>In-frame_ENST00000304164_ENST00000374309_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(transcript)=404nt_BP=228nt
GCCCCGCAGCCCCGGGCTGGGCCCGCGTCCCGGAGCGCCACCGGAGAGCGAGGACGACGTGGAGGCGGAGTGGCGCCCGGCGAGCTGGAG
ACCATGGCCAAAATGGAGGTGAAAACCTCACTTCTGGACAATATGATTGGAGTTGGGGATATGGTTCTTTTAGAACCTCTCAATGAGGAG
ACCTTCATCAACAACCTCAAGAAGCGCTTTGACCACAGTGAAATATACGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGTTATCCATT
TGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGGGGAGATTC

>In-frame_ENST00000304164_ENST00000374309_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(amino acids)=72AA_start in transcript=217_stop in transcript=2

--------------------------------------------------------------
>In-frame_ENST00000392316_ENST00000331683_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(transcript)=508nt_BP=146nt
AGCTGGAGACCATGGCCAAAATGGAGGTGAAAACCTCACTTCTGGACAATATGATTGGAGTTGGGGATATGGTTCTTTTAGAACCTCTCA
ATGAGGAGACCTTCATCAACAACCTCAAGAAGCGCTTTGACCACAGTGAAATATACGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGT
TATCCATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGG
GGAGATTCTCTTTTCTGGAGGCTCTGACGGCACAGTTCGAACGTGGTCTTGACCGTCAGCACATCCCGCTGCAGAGGGCATTCCCTTTAA
GGCTTGAAAATGCCTCCTGTAGTCCCAAACCAGCAAAGAACTGGTTAAATGTGCCAGCAGGTAACATTTACAGTCTGCTTTAAAACATGC

>In-frame_ENST00000392316_ENST00000331683_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(amino acids)=65AA_start in transcript=458_stop in transcript=261

--------------------------------------------------------------
>In-frame_ENST00000392316_ENST00000374309_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(transcript)=322nt_BP=146nt
AGCTGGAGACCATGGCCAAAATGGAGGTGAAAACCTCACTTCTGGACAATATGATTGGAGTTGGGGATATGGTTCTTTTAGAACCTCTCA
ATGAGGAGACCTTCATCAACAACCTCAAGAAGCGCTTTGACCACAGTGAAATATACGTCGAGTTTTAGCTCAGGCAAGTGGCAATGGTGT
TATCCATTTGCTAGATCTTAAATCTGGGGAGATTCACAAATTGATGGGCCACGAAAACGAGGCACACACGGTTGTGTTTTCTCACGACGG

>In-frame_ENST00000392316_ENST00000374309_TCGA-G9-6499-01A_MYO1B_chr2_192141756_+_SPAG16_chr2_215274864_length(amino acids)=51AA_start in transcript=2_stop in transcript=157

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MYO1B-SPAG16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYO1B-SPAG16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MYO1B-SPAG16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYO1BC0019209Hepatomegaly1CTD_human
HgeneMYO1BC0043094Weight Gain1CTD_human