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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MYO1D-ASIC2 (FusionGDB2 ID:56305)

Fusion Gene Summary for MYO1D-ASIC2

check button Fusion gene summary
Fusion gene informationFusion gene name: MYO1D-ASIC2
Fusion gene ID: 56305
HgeneTgene
Gene symbol

MYO1D

ASIC2

Gene ID

4642

40

Gene namemyosin IDacid sensing ion channel subunit 2
SynonymsPPP1R108|myr4ACCN|ACCN1|ASIC2a|BNC1|BNaC1|MDEG|hBNaC1
Cytomap

17q11.2

17q11.2-q12

Type of geneprotein-codingprotein-coding
Descriptionunconventional myosin-Idmyosin-I gammaprotein phosphatase 1, regulatory subunit 108acid-sensing ion channel 2acid sensing (proton gated) ion channel 2amiloride-sensitive cation channel 1, neuronalbrain sodium channel 1mammalian degenerin homologneuronal amiloride-sensitive cation channel 1
Modification date2020031320200313
UniProtAcc

O94832

Q16515

Ensembl transtripts involved in fusion geneENST00000318217, ENST00000394649, 
ENST00000579584, ENST00000584232, 
ENST00000583621, 		ENST00000225823, 
ENST00000359872, ENST00000448983, 
Fusion gene scores* DoF score24 X 17 X 12=489618 X 14 X 7=1764
# samples 2819
** MAII scorelog2(28/4896*10)=-4.12810482574769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1764*10)=-3.21477923722657
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MYO1D [Title/Abstract] AND ASIC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMYO1D(31203796)-ASIC2(31355410), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYO1D

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across MYO1D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ASIC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-7155-01AMYO1Dchr17

31203796

-ASIC2chr17

31355410

-
ChimerDB4SARCTCGA-PC-A5DL-01AMYO1Dchr17

31203796

-ASIC2chr17

31355410

-


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Fusion Gene ORF analysis for MYO1D-ASIC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000318217ENST00000225823MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
In-frameENST00000318217ENST00000359872MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
5CDS-5UTRENST00000318217ENST00000448983MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
intron-3CDSENST00000394649ENST00000225823MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
intron-3CDSENST00000394649ENST00000359872MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
intron-5UTRENST00000394649ENST00000448983MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
In-frameENST00000579584ENST00000225823MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
In-frameENST00000579584ENST00000359872MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
5CDS-5UTRENST00000579584ENST00000448983MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
intron-3CDSENST00000584232ENST00000225823MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
intron-3CDSENST00000584232ENST00000359872MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
intron-5UTRENST00000584232ENST00000448983MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
In-frameENST00000583621ENST00000225823MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
In-frameENST00000583621ENST00000359872MYO1Dchr17

31203796

-ASIC2chr17

31355410

-
5CDS-5UTRENST00000583621ENST00000448983MYO1Dchr17

31203796

-ASIC2chr17

31355410

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000318217MYO1Dchr1731203796-ENST00000225823ASIC2chr1731355410-19834004091104231
ENST00000318217MYO1Dchr1731203796-ENST00000359872ASIC2chr1731355410-19834004091104231
ENST00000579584MYO1Dchr1731203796-ENST00000225823ASIC2chr1731355410-19503673761071231
ENST00000579584MYO1Dchr1731203796-ENST00000359872ASIC2chr1731355410-19503673761071231
ENST00000583621MYO1Dchr1731203796-ENST00000225823ASIC2chr1731355410-19834004091104231
ENST00000583621MYO1Dchr1731203796-ENST00000359872ASIC2chr1731355410-19834004091104231

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000318217ENST00000225823MYO1Dchr1731203796-ASIC2chr1731355410-0.0052854140.99471456
ENST00000318217ENST00000359872MYO1Dchr1731203796-ASIC2chr1731355410-0.0052854140.99471456
ENST00000579584ENST00000225823MYO1Dchr1731203796-ASIC2chr1731355410-0.0059350990.994065
ENST00000579584ENST00000359872MYO1Dchr1731203796-ASIC2chr1731355410-0.0059350990.994065
ENST00000583621ENST00000225823MYO1Dchr1731203796-ASIC2chr1731355410-0.0052854140.99471456
ENST00000583621ENST00000359872MYO1Dchr1731203796-ASIC2chr1731355410-0.0052854140.99471456

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Fusion Genomic Features for MYO1D-ASIC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MYO1D-ASIC2


check button Go to

FGviewer for the breakpoints of chr17:31203796-chr17:31355410

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYO1D

O94832

ASIC2

Q16515

FUNCTION: Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). {ECO:0000250|UniProtKB:F1PRN2, ECO:0000250|UniProtKB:Q63357}.FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneASIC2chr17:31203796chr17:31355410ENST00000225823210449_512329.0564.0Topological domainCytoplasmic
TgeneASIC2chr17:31203796chr17:31355410ENST00000359872210449_512278.0513.0Topological domainCytoplasmic
TgeneASIC2chr17:31203796chr17:31355410ENST00000225823210428_448329.0564.0TransmembraneHelical
TgeneASIC2chr17:31203796chr17:31355410ENST00000359872210428_448278.0513.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYO1Dchr17:31203796chr17:31355410ENST00000318217-122699_71931.6666666666666681007.0DomainIQ 1
HgeneMYO1Dchr17:31203796chr17:31355410ENST00000318217-122721_74131.6666666666666681007.0DomainIQ 2
HgeneMYO1Dchr17:31203796chr17:31355410ENST00000318217-122812_100531.6666666666666681007.0DomainTH1
HgeneMYO1Dchr17:31203796chr17:31355410ENST00000318217-1229_69531.6666666666666681007.0DomainMyosin motor
HgeneMYO1Dchr17:31203796chr17:31355410ENST00000318217-122102_10931.6666666666666681007.0Nucleotide bindingATP
HgeneMYO1Dchr17:31203796chr17:31355410ENST00000318217-122572_59431.6666666666666681007.0RegionActin-binding
TgeneASIC2chr17:31203796chr17:31355410ENST000002258232101_37329.0564.0Topological domainCytoplasmic
TgeneASIC2chr17:31203796chr17:31355410ENST0000022582321059_427329.0564.0Topological domainExtracellular
TgeneASIC2chr17:31203796chr17:31355410ENST000003598722101_37278.0513.0Topological domainCytoplasmic
TgeneASIC2chr17:31203796chr17:31355410ENST0000035987221059_427278.0513.0Topological domainExtracellular
TgeneASIC2chr17:31203796chr17:31355410ENST0000022582321038_58329.0564.0TransmembraneHelical
TgeneASIC2chr17:31203796chr17:31355410ENST0000035987221038_58278.0513.0TransmembraneHelical


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Fusion Gene Sequence for MYO1D-ASIC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000318217_ENST00000225823_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(transcript)=1983nt_BP=400nt
AGGCTGGAGGCGGGACCAGCCGCTGCCGTCTCCGTCTCGGTGTCCCGGCCCCTACAGCGCCCGGCAGCCGCGGCGGGAGGAGCGGAAACT
GTCGGGTGCGTCCCGTTCGGAGCCGCGCCGGCCGAGAAGGCGCCGAGGAGCAGCGAGGCGGCCTCTGTCCGGCCCGGACCCGCCGAGCGG
CGTGCGCGCCCCCTCCCCGTAGCCTCGCGGCGCGGCCTCGCCCCGGCCCCTCCCGAGCTCATCGCGGGCCCACGGAGCGGCCCCGGAGGC
CCGAGCGCGCCCACCTGAGCCCCCGCGCTGGCGCCATGGCGGAGCAGGAGAGCCTGGAATTCGGCAAGGCAGACTTCGTGCTGATGGACA
CCGTCTCCATGCCCGAGTTCATGGCCAACCTCAGGCTCAGCTCACATACCTGCCCCCACCGTGGGGTGAGTGCCGATCCTCAGAGATGGG
CCTCGACTTTTTTCCTGTTTACAGCATCACCGCCTGTAGGATTGACTGTGAGACCCGCTACATTGTGGAAAACTGCAACTGCCGCATGGT
TCACATGCCAGGGGATGCCCCTTTTTGTACCCCTGAGCAGCACAAGGAGTGTGCAGAGCCTGCCCTAGGTCTGTTGGCGGAAAAGGACAG
CAATTACTGTCTCTGCAGGACACCCTGCAACCTAACCCGCTACAACAAAGAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCCAA
GTACCTTGAGAAGAAATTTAACAAATCAGAAAAATATATCTCAGAGAACATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGA
GACAATTGAACAGAAGAAGGCGTATGAAGTTGCTGCCTTACTTGGTGATATTGGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCT
TACAATACTAGAGCTCTTTGATTATATTTATGAGCTGATCAAAGAGAAGCTATTAGACCTGCTTGGCAAAGAGGAGGACGAAGGGAGCCA
CGATGAGAATGTGAGTACTTGTGACACAATGCCAAACCACTCTGAAACCATCAGTCACACTGTGAACGTGCCCCTGCAGACGACCCTGGG
GACCTTGGAGGAGATTGCCTGCTGACACCCCTCGAGTCACCCAGCACTCCCTCCAAACAGACCTTGAGGCCCAAGACCCAGGACAAGGAA
CAGCAAGCTCAGGTGGGATGGCCCCAGTGCTGGAAAGAAGCAAGAGCCCCCTATGCACACATTGCAGACTAGCTGCCTAGACCTCGCTCC
GGCCACGTCCAACACGACGCATCCTTGGGCCCCGCCGTGCGTCCCTCTTAGGAGAGATGAGTCACACTCTGGAACTGTCCAAGAACGAAC
CTGCCATCACATCTCACTGCCAGATGTATAAAGCACCTGCATGCTCAGACTTCTTGTGGCGCCACCTCCACGTCTGTCTTGTACATGACA
CTCCTCCACGCGGTTTCCAGTGTCCACACTGCTGCCCGTGCAGTGGGACCAGATTCCAGGTCCAAAGTCACCATGAGGCCACCCTGGAAT
CAGAACTGCACAATCAAGAGGGAACCCATGGGACTCTCTGCTACATTCAGTTCTTGTGTCGTTTGTGAAAGTTCTTAACCTGCCCAAAAA
CCCCCTTTTCCCCAAGCTGCCCATGGGGCTTCGGCGCCAAAGGTGACCCGCGCCAACCTCCCTCCCCCCCAGTGCCTATGACGGCGGCAC
AGCAGCCAGCGGGTGGGGGACGCCTGTGTTCACCCATGGTGCCCATGTCGTTCTTCTCTCCCTGTGACACAGCTTGTACAGTCTGATTCT
TTTTATCTGGGGTAGGGGGGCTTTTATGTTTGTCCGATGGAGATTTGTTTTGTTTTGCTTCATTTTATGCTTTTTTATTTTAGTTTTGAT
GTTCTGAGGTTTGCTTTGGTTTTTCCATTTTCTTTGGCATTTATTTATTCGTGCTTCAAATCACAGTCATATTAAAAGCTGGTCTTGTGG

>In-frame_ENST00000318217_ENST00000225823_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(amino acids)=231AA_start in transcript=409_stop in transcript=1104
MPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNK
ELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEK

--------------------------------------------------------------
>In-frame_ENST00000318217_ENST00000359872_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(transcript)=1983nt_BP=400nt
AGGCTGGAGGCGGGACCAGCCGCTGCCGTCTCCGTCTCGGTGTCCCGGCCCCTACAGCGCCCGGCAGCCGCGGCGGGAGGAGCGGAAACT
GTCGGGTGCGTCCCGTTCGGAGCCGCGCCGGCCGAGAAGGCGCCGAGGAGCAGCGAGGCGGCCTCTGTCCGGCCCGGACCCGCCGAGCGG
CGTGCGCGCCCCCTCCCCGTAGCCTCGCGGCGCGGCCTCGCCCCGGCCCCTCCCGAGCTCATCGCGGGCCCACGGAGCGGCCCCGGAGGC
CCGAGCGCGCCCACCTGAGCCCCCGCGCTGGCGCCATGGCGGAGCAGGAGAGCCTGGAATTCGGCAAGGCAGACTTCGTGCTGATGGACA
CCGTCTCCATGCCCGAGTTCATGGCCAACCTCAGGCTCAGCTCACATACCTGCCCCCACCGTGGGGTGAGTGCCGATCCTCAGAGATGGG
CCTCGACTTTTTTCCTGTTTACAGCATCACCGCCTGTAGGATTGACTGTGAGACCCGCTACATTGTGGAAAACTGCAACTGCCGCATGGT
TCACATGCCAGGGGATGCCCCTTTTTGTACCCCTGAGCAGCACAAGGAGTGTGCAGAGCCTGCCCTAGGTCTGTTGGCGGAAAAGGACAG
CAATTACTGTCTCTGCAGGACACCCTGCAACCTAACCCGCTACAACAAAGAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCCAA
GTACCTTGAGAAGAAATTTAACAAATCAGAAAAATATATCTCAGAGAACATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGA
GACAATTGAACAGAAGAAGGCGTATGAAGTTGCTGCCTTACTTGGTGATATTGGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCT
TACAATACTAGAGCTCTTTGATTATATTTATGAGCTGATCAAAGAGAAGCTATTAGACCTGCTTGGCAAAGAGGAGGACGAAGGGAGCCA
CGATGAGAATGTGAGTACTTGTGACACAATGCCAAACCACTCTGAAACCATCAGTCACACTGTGAACGTGCCCCTGCAGACGACCCTGGG
GACCTTGGAGGAGATTGCCTGCTGACACCCCTCGAGTCACCCAGCACTCCCTCCAAACAGACCTTGAGGCCCAAGACCCAGGACAAGGAA
CAGCAAGCTCAGGTGGGATGGCCCCAGTGCTGGAAAGAAGCAAGAGCCCCCTATGCACACATTGCAGACTAGCTGCCTAGACCTCGCTCC
GGCCACGTCCAACACGACGCATCCTTGGGCCCCGCCGTGCGTCCCTCTTAGGAGAGATGAGTCACACTCTGGAACTGTCCAAGAACGAAC
CTGCCATCACATCTCACTGCCAGATGTATAAAGCACCTGCATGCTCAGACTTCTTGTGGCGCCACCTCCACGTCTGTCTTGTACATGACA
CTCCTCCACGCGGTTTCCAGTGTCCACACTGCTGCCCGTGCAGTGGGACCAGATTCCAGGTCCAAAGTCACCATGAGGCCACCCTGGAAT
CAGAACTGCACAATCAAGAGGGAACCCATGGGACTCTCTGCTACATTCAGTTCTTGTGTCGTTTGTGAAAGTTCTTAACCTGCCCAAAAA
CCCCCTTTTCCCCAAGCTGCCCATGGGGCTTCGGCGCCAAAGGTGACCCGCGCCAACCTCCCTCCCCCCCAGTGCCTATGACGGCGGCAC
AGCAGCCAGCGGGTGGGGGACGCCTGTGTTCACCCATGGTGCCCATGTCGTTCTTCTCTCCCTGTGACACAGCTTGTACAGTCTGATTCT
TTTTATCTGGGGTAGGGGGGCTTTTATGTTTGTCCGATGGAGATTTGTTTTGTTTTGCTTCATTTTATGCTTTTTTATTTTAGTTTTGAT
GTTCTGAGGTTTGCTTTGGTTTTTCCATTTTCTTTGGCATTTATTTATTCGTGCTTCAAATCACAGTCATATTAAAAGCTGGTCTTGTGG

>In-frame_ENST00000318217_ENST00000359872_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(amino acids)=231AA_start in transcript=409_stop in transcript=1104
MPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNK
ELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEK

--------------------------------------------------------------
>In-frame_ENST00000579584_ENST00000225823_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(transcript)=1950nt_BP=367nt
GTCTCGGTGTCCCGGCCCCTACAGCGCCCGGCAGCCGCGGCGGGAGGAGCGGAAACTGTCGGGTGCGTCCCGTTCGGAGCCGCGCCGGCC
GAGAAGGCGCCGAGGAGCAGCGAGGCGGCCTCTGTCCGGCCCGGACCCGCCGAGCGGCGTGCGCGCCCCCTCCCCGTAGCCTCGCGGCGC
GGCCTCGCCCCGGCCCCTCCCGAGCTCATCGCGGGCCCACGGAGCGGCCCCGGAGGCCCGAGCGCGCCCACCTGAGCCCCCGCGCTGGCG
CCATGGCGGAGCAGGAGAGCCTGGAATTCGGCAAGGCAGACTTCGTGCTGATGGACACCGTCTCCATGCCCGAGTTCATGGCCAACCTCA
GGCTCAGCTCACATACCTGCCCCCACCGTGGGGTGAGTGCCGATCCTCAGAGATGGGCCTCGACTTTTTTCCTGTTTACAGCATCACCGC
CTGTAGGATTGACTGTGAGACCCGCTACATTGTGGAAAACTGCAACTGCCGCATGGTTCACATGCCAGGGGATGCCCCTTTTTGTACCCC
TGAGCAGCACAAGGAGTGTGCAGAGCCTGCCCTAGGTCTGTTGGCGGAAAAGGACAGCAATTACTGTCTCTGCAGGACACCCTGCAACCT
AACCCGCTACAACAAAGAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCCAAGTACCTTGAGAAGAAATTTAACAAATCAGAAAA
ATATATCTCAGAGAACATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGAGACAATTGAACAGAAGAAGGCGTATGAAGTTGC
TGCCTTACTTGGTGATATTGGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCTTACAATACTAGAGCTCTTTGATTATATTTATGA
GCTGATCAAAGAGAAGCTATTAGACCTGCTTGGCAAAGAGGAGGACGAAGGGAGCCACGATGAGAATGTGAGTACTTGTGACACAATGCC
AAACCACTCTGAAACCATCAGTCACACTGTGAACGTGCCCCTGCAGACGACCCTGGGGACCTTGGAGGAGATTGCCTGCTGACACCCCTC
GAGTCACCCAGCACTCCCTCCAAACAGACCTTGAGGCCCAAGACCCAGGACAAGGAACAGCAAGCTCAGGTGGGATGGCCCCAGTGCTGG
AAAGAAGCAAGAGCCCCCTATGCACACATTGCAGACTAGCTGCCTAGACCTCGCTCCGGCCACGTCCAACACGACGCATCCTTGGGCCCC
GCCGTGCGTCCCTCTTAGGAGAGATGAGTCACACTCTGGAACTGTCCAAGAACGAACCTGCCATCACATCTCACTGCCAGATGTATAAAG
CACCTGCATGCTCAGACTTCTTGTGGCGCCACCTCCACGTCTGTCTTGTACATGACACTCCTCCACGCGGTTTCCAGTGTCCACACTGCT
GCCCGTGCAGTGGGACCAGATTCCAGGTCCAAAGTCACCATGAGGCCACCCTGGAATCAGAACTGCACAATCAAGAGGGAACCCATGGGA
CTCTCTGCTACATTCAGTTCTTGTGTCGTTTGTGAAAGTTCTTAACCTGCCCAAAAACCCCCTTTTCCCCAAGCTGCCCATGGGGCTTCG
GCGCCAAAGGTGACCCGCGCCAACCTCCCTCCCCCCCAGTGCCTATGACGGCGGCACAGCAGCCAGCGGGTGGGGGACGCCTGTGTTCAC
CCATGGTGCCCATGTCGTTCTTCTCTCCCTGTGACACAGCTTGTACAGTCTGATTCTTTTTATCTGGGGTAGGGGGGCTTTTATGTTTGT
CCGATGGAGATTTGTTTTGTTTTGCTTCATTTTATGCTTTTTTATTTTAGTTTTGATGTTCTGAGGTTTGCTTTGGTTTTTCCATTTTCT

>In-frame_ENST00000579584_ENST00000225823_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(amino acids)=231AA_start in transcript=376_stop in transcript=1071
MPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNK
ELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEK

--------------------------------------------------------------
>In-frame_ENST00000579584_ENST00000359872_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(transcript)=1950nt_BP=367nt
GTCTCGGTGTCCCGGCCCCTACAGCGCCCGGCAGCCGCGGCGGGAGGAGCGGAAACTGTCGGGTGCGTCCCGTTCGGAGCCGCGCCGGCC
GAGAAGGCGCCGAGGAGCAGCGAGGCGGCCTCTGTCCGGCCCGGACCCGCCGAGCGGCGTGCGCGCCCCCTCCCCGTAGCCTCGCGGCGC
GGCCTCGCCCCGGCCCCTCCCGAGCTCATCGCGGGCCCACGGAGCGGCCCCGGAGGCCCGAGCGCGCCCACCTGAGCCCCCGCGCTGGCG
CCATGGCGGAGCAGGAGAGCCTGGAATTCGGCAAGGCAGACTTCGTGCTGATGGACACCGTCTCCATGCCCGAGTTCATGGCCAACCTCA
GGCTCAGCTCACATACCTGCCCCCACCGTGGGGTGAGTGCCGATCCTCAGAGATGGGCCTCGACTTTTTTCCTGTTTACAGCATCACCGC
CTGTAGGATTGACTGTGAGACCCGCTACATTGTGGAAAACTGCAACTGCCGCATGGTTCACATGCCAGGGGATGCCCCTTTTTGTACCCC
TGAGCAGCACAAGGAGTGTGCAGAGCCTGCCCTAGGTCTGTTGGCGGAAAAGGACAGCAATTACTGTCTCTGCAGGACACCCTGCAACCT
AACCCGCTACAACAAAGAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCCAAGTACCTTGAGAAGAAATTTAACAAATCAGAAAA
ATATATCTCAGAGAACATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGAGACAATTGAACAGAAGAAGGCGTATGAAGTTGC
TGCCTTACTTGGTGATATTGGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCTTACAATACTAGAGCTCTTTGATTATATTTATGA
GCTGATCAAAGAGAAGCTATTAGACCTGCTTGGCAAAGAGGAGGACGAAGGGAGCCACGATGAGAATGTGAGTACTTGTGACACAATGCC
AAACCACTCTGAAACCATCAGTCACACTGTGAACGTGCCCCTGCAGACGACCCTGGGGACCTTGGAGGAGATTGCCTGCTGACACCCCTC
GAGTCACCCAGCACTCCCTCCAAACAGACCTTGAGGCCCAAGACCCAGGACAAGGAACAGCAAGCTCAGGTGGGATGGCCCCAGTGCTGG
AAAGAAGCAAGAGCCCCCTATGCACACATTGCAGACTAGCTGCCTAGACCTCGCTCCGGCCACGTCCAACACGACGCATCCTTGGGCCCC
GCCGTGCGTCCCTCTTAGGAGAGATGAGTCACACTCTGGAACTGTCCAAGAACGAACCTGCCATCACATCTCACTGCCAGATGTATAAAG
CACCTGCATGCTCAGACTTCTTGTGGCGCCACCTCCACGTCTGTCTTGTACATGACACTCCTCCACGCGGTTTCCAGTGTCCACACTGCT
GCCCGTGCAGTGGGACCAGATTCCAGGTCCAAAGTCACCATGAGGCCACCCTGGAATCAGAACTGCACAATCAAGAGGGAACCCATGGGA
CTCTCTGCTACATTCAGTTCTTGTGTCGTTTGTGAAAGTTCTTAACCTGCCCAAAAACCCCCTTTTCCCCAAGCTGCCCATGGGGCTTCG
GCGCCAAAGGTGACCCGCGCCAACCTCCCTCCCCCCCAGTGCCTATGACGGCGGCACAGCAGCCAGCGGGTGGGGGACGCCTGTGTTCAC
CCATGGTGCCCATGTCGTTCTTCTCTCCCTGTGACACAGCTTGTACAGTCTGATTCTTTTTATCTGGGGTAGGGGGGCTTTTATGTTTGT
CCGATGGAGATTTGTTTTGTTTTGCTTCATTTTATGCTTTTTTATTTTAGTTTTGATGTTCTGAGGTTTGCTTTGGTTTTTCCATTTTCT

>In-frame_ENST00000579584_ENST00000359872_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(amino acids)=231AA_start in transcript=376_stop in transcript=1071
MPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNK
ELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEK

--------------------------------------------------------------
>In-frame_ENST00000583621_ENST00000225823_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(transcript)=1983nt_BP=400nt
AGGCTGGAGGCGGGACCAGCCGCTGCCGTCTCCGTCTCGGTGTCCCGGCCCCTACAGCGCCCGGCAGCCGCGGCGGGAGGAGCGGAAACT
GTCGGGTGCGTCCCGTTCGGAGCCGCGCCGGCCGAGAAGGCGCCGAGGAGCAGCGAGGCGGCCTCTGTCCGGCCCGGACCCGCCGAGCGG
CGTGCGCGCCCCCTCCCCGTAGCCTCGCGGCGCGGCCTCGCCCCGGCCCCTCCCGAGCTCATCGCGGGCCCACGGAGCGGCCCCGGAGGC
CCGAGCGCGCCCACCTGAGCCCCCGCGCTGGCGCCATGGCGGAGCAGGAGAGCCTGGAATTCGGCAAGGCAGACTTCGTGCTGATGGACA
CCGTCTCCATGCCCGAGTTCATGGCCAACCTCAGGCTCAGCTCACATACCTGCCCCCACCGTGGGGTGAGTGCCGATCCTCAGAGATGGG
CCTCGACTTTTTTCCTGTTTACAGCATCACCGCCTGTAGGATTGACTGTGAGACCCGCTACATTGTGGAAAACTGCAACTGCCGCATGGT
TCACATGCCAGGGGATGCCCCTTTTTGTACCCCTGAGCAGCACAAGGAGTGTGCAGAGCCTGCCCTAGGTCTGTTGGCGGAAAAGGACAG
CAATTACTGTCTCTGCAGGACACCCTGCAACCTAACCCGCTACAACAAAGAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCCAA
GTACCTTGAGAAGAAATTTAACAAATCAGAAAAATATATCTCAGAGAACATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGA
GACAATTGAACAGAAGAAGGCGTATGAAGTTGCTGCCTTACTTGGTGATATTGGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCT
TACAATACTAGAGCTCTTTGATTATATTTATGAGCTGATCAAAGAGAAGCTATTAGACCTGCTTGGCAAAGAGGAGGACGAAGGGAGCCA
CGATGAGAATGTGAGTACTTGTGACACAATGCCAAACCACTCTGAAACCATCAGTCACACTGTGAACGTGCCCCTGCAGACGACCCTGGG
GACCTTGGAGGAGATTGCCTGCTGACACCCCTCGAGTCACCCAGCACTCCCTCCAAACAGACCTTGAGGCCCAAGACCCAGGACAAGGAA
CAGCAAGCTCAGGTGGGATGGCCCCAGTGCTGGAAAGAAGCAAGAGCCCCCTATGCACACATTGCAGACTAGCTGCCTAGACCTCGCTCC
GGCCACGTCCAACACGACGCATCCTTGGGCCCCGCCGTGCGTCCCTCTTAGGAGAGATGAGTCACACTCTGGAACTGTCCAAGAACGAAC
CTGCCATCACATCTCACTGCCAGATGTATAAAGCACCTGCATGCTCAGACTTCTTGTGGCGCCACCTCCACGTCTGTCTTGTACATGACA
CTCCTCCACGCGGTTTCCAGTGTCCACACTGCTGCCCGTGCAGTGGGACCAGATTCCAGGTCCAAAGTCACCATGAGGCCACCCTGGAAT
CAGAACTGCACAATCAAGAGGGAACCCATGGGACTCTCTGCTACATTCAGTTCTTGTGTCGTTTGTGAAAGTTCTTAACCTGCCCAAAAA
CCCCCTTTTCCCCAAGCTGCCCATGGGGCTTCGGCGCCAAAGGTGACCCGCGCCAACCTCCCTCCCCCCCAGTGCCTATGACGGCGGCAC
AGCAGCCAGCGGGTGGGGGACGCCTGTGTTCACCCATGGTGCCCATGTCGTTCTTCTCTCCCTGTGACACAGCTTGTACAGTCTGATTCT
TTTTATCTGGGGTAGGGGGGCTTTTATGTTTGTCCGATGGAGATTTGTTTTGTTTTGCTTCATTTTATGCTTTTTTATTTTAGTTTTGAT
GTTCTGAGGTTTGCTTTGGTTTTTCCATTTTCTTTGGCATTTATTTATTCGTGCTTCAAATCACAGTCATATTAAAAGCTGGTCTTGTGG

>In-frame_ENST00000583621_ENST00000225823_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(amino acids)=231AA_start in transcript=409_stop in transcript=1104
MPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNK
ELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEK

--------------------------------------------------------------
>In-frame_ENST00000583621_ENST00000359872_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(transcript)=1983nt_BP=400nt
AGGCTGGAGGCGGGACCAGCCGCTGCCGTCTCCGTCTCGGTGTCCCGGCCCCTACAGCGCCCGGCAGCCGCGGCGGGAGGAGCGGAAACT
GTCGGGTGCGTCCCGTTCGGAGCCGCGCCGGCCGAGAAGGCGCCGAGGAGCAGCGAGGCGGCCTCTGTCCGGCCCGGACCCGCCGAGCGG
CGTGCGCGCCCCCTCCCCGTAGCCTCGCGGCGCGGCCTCGCCCCGGCCCCTCCCGAGCTCATCGCGGGCCCACGGAGCGGCCCCGGAGGC
CCGAGCGCGCCCACCTGAGCCCCCGCGCTGGCGCCATGGCGGAGCAGGAGAGCCTGGAATTCGGCAAGGCAGACTTCGTGCTGATGGACA
CCGTCTCCATGCCCGAGTTCATGGCCAACCTCAGGCTCAGCTCACATACCTGCCCCCACCGTGGGGTGAGTGCCGATCCTCAGAGATGGG
CCTCGACTTTTTTCCTGTTTACAGCATCACCGCCTGTAGGATTGACTGTGAGACCCGCTACATTGTGGAAAACTGCAACTGCCGCATGGT
TCACATGCCAGGGGATGCCCCTTTTTGTACCCCTGAGCAGCACAAGGAGTGTGCAGAGCCTGCCCTAGGTCTGTTGGCGGAAAAGGACAG
CAATTACTGTCTCTGCAGGACACCCTGCAACCTAACCCGCTACAACAAAGAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCCAA
GTACCTTGAGAAGAAATTTAACAAATCAGAAAAATATATCTCAGAGAACATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGA
GACAATTGAACAGAAGAAGGCGTATGAAGTTGCTGCCTTACTTGGTGATATTGGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCT
TACAATACTAGAGCTCTTTGATTATATTTATGAGCTGATCAAAGAGAAGCTATTAGACCTGCTTGGCAAAGAGGAGGACGAAGGGAGCCA
CGATGAGAATGTGAGTACTTGTGACACAATGCCAAACCACTCTGAAACCATCAGTCACACTGTGAACGTGCCCCTGCAGACGACCCTGGG
GACCTTGGAGGAGATTGCCTGCTGACACCCCTCGAGTCACCCAGCACTCCCTCCAAACAGACCTTGAGGCCCAAGACCCAGGACAAGGAA
CAGCAAGCTCAGGTGGGATGGCCCCAGTGCTGGAAAGAAGCAAGAGCCCCCTATGCACACATTGCAGACTAGCTGCCTAGACCTCGCTCC
GGCCACGTCCAACACGACGCATCCTTGGGCCCCGCCGTGCGTCCCTCTTAGGAGAGATGAGTCACACTCTGGAACTGTCCAAGAACGAAC
CTGCCATCACATCTCACTGCCAGATGTATAAAGCACCTGCATGCTCAGACTTCTTGTGGCGCCACCTCCACGTCTGTCTTGTACATGACA
CTCCTCCACGCGGTTTCCAGTGTCCACACTGCTGCCCGTGCAGTGGGACCAGATTCCAGGTCCAAAGTCACCATGAGGCCACCCTGGAAT
CAGAACTGCACAATCAAGAGGGAACCCATGGGACTCTCTGCTACATTCAGTTCTTGTGTCGTTTGTGAAAGTTCTTAACCTGCCCAAAAA
CCCCCTTTTCCCCAAGCTGCCCATGGGGCTTCGGCGCCAAAGGTGACCCGCGCCAACCTCCCTCCCCCCCAGTGCCTATGACGGCGGCAC
AGCAGCCAGCGGGTGGGGGACGCCTGTGTTCACCCATGGTGCCCATGTCGTTCTTCTCTCCCTGTGACACAGCTTGTACAGTCTGATTCT
TTTTATCTGGGGTAGGGGGGCTTTTATGTTTGTCCGATGGAGATTTGTTTTGTTTTGCTTCATTTTATGCTTTTTTATTTTAGTTTTGAT
GTTCTGAGGTTTGCTTTGGTTTTTCCATTTTCTTTGGCATTTATTTATTCGTGCTTCAAATCACAGTCATATTAAAAGCTGGTCTTGTGG

>In-frame_ENST00000583621_ENST00000359872_TCGA-78-7155-01A_MYO1D_chr17_31203796_-_ASIC2_chr17_31355410_length(amino acids)=231AA_start in transcript=409_stop in transcript=1104
MPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNK
ELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MYO1D-ASIC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MYO1D-ASIC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneASIC2Q16515DB00594AmilorideInhibitorSmall moleculeApproved
TgeneASIC2Q16515DB00594AmilorideInhibitorSmall moleculeApproved
TgeneASIC2Q16515DB00594AmilorideInhibitorSmall moleculeApproved
TgeneASIC2Q16515DB00594AmilorideInhibitorSmall moleculeApproved
TgeneASIC2Q16515DB00594AmilorideInhibitorSmall moleculeApproved

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Related Diseases for MYO1D-ASIC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYO1DC0004352Autistic Disorder1CTD_human
TgeneASIC2C0004352Autistic Disorder1CTD_human
TgeneASIC2C0021368Inflammation1CTD_human