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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APOC1-IQCE (FusionGDB2 ID:5656)

Fusion Gene Summary for APOC1-IQCE

check button Fusion gene summary
Fusion gene informationFusion gene name: APOC1-IQCE
Fusion gene ID: 5656
HgeneTgene
Gene symbol

APOC1

IQCE

Gene ID

341

23288

Gene nameapolipoprotein C1IQ motif containing E
SynonymsApo-CI|ApoC-I|apo-CIB|apoC-IB1700028P05Rik|PAPA7
Cytomap

19q13.32

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionapolipoprotein C-IIQ domain-containing protein E
Modification date2020031320200313
UniProtAcc.

Q6IPM2

Ensembl transtripts involved in fusion geneENST00000588750, ENST00000588802, 
ENST00000252491, ENST00000592885, 
ENST00000589781, ENST00000586638, 
ENST00000404984, ENST00000402050, 
ENST00000438376, ENST00000325979, 
ENST00000497572, 
Fusion gene scores* DoF score5 X 3 X 4=6012 X 3 X 9=324
# samples 512
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APOC1 [Title/Abstract] AND IQCE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPOC1(45422606)-IQCE(2641075), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPOC1

GO:0010900

negative regulation of phosphatidylcholine catabolic process

2302419

HgeneAPOC1

GO:0010916

negative regulation of very-low-density lipoprotein particle clearance

1917954

HgeneAPOC1

GO:0032375

negative regulation of cholesterol transport

10978346

HgeneAPOC1

GO:0033344

cholesterol efflux

11162594

HgeneAPOC1

GO:0033700

phospholipid efflux

11162594

HgeneAPOC1

GO:0034369

plasma lipoprotein particle remodeling

10978346

HgeneAPOC1

GO:0034382

chylomicron remnant clearance

4020294

HgeneAPOC1

GO:0045717

negative regulation of fatty acid biosynthetic process

15576844

HgeneAPOC1

GO:0045833

negative regulation of lipid metabolic process

182536

HgeneAPOC1

GO:0048261

negative regulation of receptor-mediated endocytosis

1917954

HgeneAPOC1

GO:0050995

negative regulation of lipid catabolic process

15576844

HgeneAPOC1

GO:0051005

negative regulation of lipoprotein lipase activity

15576844


check buttonFusion gene breakpoints across APOC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IQCE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-A4P7-01AAPOC1chr19

45422606

-IQCEchr7

2641075

+


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Fusion Gene ORF analysis for APOC1-IQCE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000588750ENST00000404984APOC1chr19

45422606

-IQCEchr7

2641075

+
intron-3CDSENST00000588750ENST00000402050APOC1chr19

45422606

-IQCEchr7

2641075

+
intron-3CDSENST00000588750ENST00000438376APOC1chr19

45422606

-IQCEchr7

2641075

+
intron-3CDSENST00000588750ENST00000325979APOC1chr19

45422606

-IQCEchr7

2641075

+
intron-intronENST00000588750ENST00000497572APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000588802ENST00000404984APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000588802ENST00000402050APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000588802ENST00000438376APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000588802ENST00000325979APOC1chr19

45422606

-IQCEchr7

2641075

+
5CDS-intronENST00000588802ENST00000497572APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000252491ENST00000404984APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000252491ENST00000402050APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000252491ENST00000438376APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000252491ENST00000325979APOC1chr19

45422606

-IQCEchr7

2641075

+
5CDS-intronENST00000252491ENST00000497572APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000592885ENST00000404984APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000592885ENST00000402050APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000592885ENST00000438376APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000592885ENST00000325979APOC1chr19

45422606

-IQCEchr7

2641075

+
5CDS-intronENST00000592885ENST00000497572APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000589781ENST00000404984APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000589781ENST00000402050APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000589781ENST00000438376APOC1chr19

45422606

-IQCEchr7

2641075

+
Frame-shiftENST00000589781ENST00000325979APOC1chr19

45422606

-IQCEchr7

2641075

+
5CDS-intronENST00000589781ENST00000497572APOC1chr19

45422606

-IQCEchr7

2641075

+
In-frameENST00000586638ENST00000404984APOC1chr19

45422606

-IQCEchr7

2641075

+
In-frameENST00000586638ENST00000402050APOC1chr19

45422606

-IQCEchr7

2641075

+
In-frameENST00000586638ENST00000438376APOC1chr19

45422606

-IQCEchr7

2641075

+
In-frameENST00000586638ENST00000325979APOC1chr19

45422606

-IQCEchr7

2641075

+
5CDS-intronENST00000586638ENST00000497572APOC1chr19

45422606

-IQCEchr7

2641075

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000586638APOC1chr1945422606-ENST00000404984IQCEchr72641075+547642536053081174
ENST00000586638APOC1chr1945422606-ENST00000402050IQCEchr72641075+547742536053081174
ENST00000586638APOC1chr1945422606-ENST00000438376IQCEchr72641075+905425440904155
ENST00000586638APOC1chr1945422606-ENST00000325979IQCEchr72641075+905425440904155

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000586638ENST00000404984APOC1chr1945422606-IQCEchr72641075+0.786825060.21317498
ENST00000586638ENST00000402050APOC1chr1945422606-IQCEchr72641075+0.824615240.17538473
ENST00000586638ENST00000438376APOC1chr1945422606-IQCEchr72641075+0.05465360.9453464
ENST00000586638ENST00000325979APOC1chr1945422606-IQCEchr72641075+0.05465360.9453464

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Fusion Genomic Features for APOC1-IQCE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for APOC1-IQCE


check button Go to

FGviewer for the breakpoints of chr19:45422606-chr7:2641075

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IQCE

Q6IPM2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). {ECO:0000250|UniProtKB:Q6PCQ0, ECO:0000269|PubMed:28488682}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIQCEchr19:45422606chr7:2641075ENST000003259791420534_539471.0631.0Compositional biasNote=Poly-Lys
TgeneIQCEchr19:45422606chr7:2641075ENST000004020501622534_539536.0696.0Compositional biasNote=Poly-Lys
TgeneIQCEchr19:45422606chr7:2641075ENST000004049841521534_539485.0645.0Compositional biasNote=Poly-Lys
TgeneIQCEchr19:45422606chr7:2641075ENST000004383761521534_539520.0680.0Compositional biasNote=Poly-Lys
TgeneIQCEchr19:45422606chr7:2641075ENST000003259791420542_571471.0631.0DomainIQ 1
TgeneIQCEchr19:45422606chr7:2641075ENST000003259791420601_630471.0631.0DomainIQ 2
TgeneIQCEchr19:45422606chr7:2641075ENST000004020501622542_571536.0696.0DomainIQ 1
TgeneIQCEchr19:45422606chr7:2641075ENST000004020501622601_630536.0696.0DomainIQ 2
TgeneIQCEchr19:45422606chr7:2641075ENST000004049841521542_571485.0645.0DomainIQ 1
TgeneIQCEchr19:45422606chr7:2641075ENST000004049841521601_630485.0645.0DomainIQ 2
TgeneIQCEchr19:45422606chr7:2641075ENST000004383761521542_571520.0680.0DomainIQ 1
TgeneIQCEchr19:45422606chr7:2641075ENST000004383761521601_630520.0680.0DomainIQ 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIQCEchr19:45422606chr7:2641075ENST000003259791420157_264471.0631.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr19:45422606chr7:2641075ENST000003259791420292_358471.0631.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr19:45422606chr7:2641075ENST000003259791420387_477471.0631.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr19:45422606chr7:2641075ENST000004020501622157_264536.0696.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr19:45422606chr7:2641075ENST000004020501622292_358536.0696.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr19:45422606chr7:2641075ENST000004020501622387_477536.0696.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr19:45422606chr7:2641075ENST000004049841521157_264485.0645.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr19:45422606chr7:2641075ENST000004049841521292_358485.0645.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr19:45422606chr7:2641075ENST000004049841521387_477485.0645.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr19:45422606chr7:2641075ENST000004383761521157_264520.0680.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr19:45422606chr7:2641075ENST000004383761521292_358520.0680.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr19:45422606chr7:2641075ENST000004383761521387_477520.0680.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for APOC1-IQCE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000586638_ENST00000404984_TCGA-86-A4P7-01A_APOC1_chr19_45422606_-_IQCE_chr7_2641075_length(transcript)=5476nt_BP=425nt
CAGAGTGCCCCTCCGGCCTCGCCATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCC
CAGCCCAGGGGACCCCAGACGTCTCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCA
GCCGCATCAAACAGAGTGAACTTTCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACA
TTTCAGAAAGTGAAGGAGAAACTCAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCC
AGCGCCTGTGCTGAGGACTCCCTCCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGG
CGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCG
TGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCA
TCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCA
GGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGG
CCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCCGACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAG
TTTAGGTCCCCGTCACTGTCTCCACGCCGTGATGGCAGCGCTGCCGAGGACATAGGAACCACGACTGGAAAGATAATTTATCGTGTTAGG
AGAAGAACGATGATACCTACTTAACACCTCAGCATCTGCGTCGTGTCTCTTTGTGCTTTTGTTTGTGGAAGGAGACCCAAATGCCTTTAC
TTTATTCTCTGGGGAGGGCCAGCGGCTCGCATCCCCCTCATCTCCAGCTGCAGCTCGGATGGTGGATTTTCAGTGCCAACAGACACATCT
GCCGTGAACTCGCAGATGCCAGGGAGCCCTGTAGTGACACGTTCTCTGACAGCACCTTGCCGCCTGCCCACGACCTTGACCGTGAGGAGC
TGCTATCCGCAACCAGCGCCGACACCATGCCCCCTCTTCCTGGTGACACCCTCAACAACCAGGATTTGCTCGATCTCAGCCCAGCAGGCC
AGGCAGACACACCCCGCTGTGCCTTAGGAAGGTGTGAGACCGGCTTCCCCCATCCCCACAGCAAAACACGGCCTGTCCCAAGCCAGTGAG
GAGCTAAAGACACCCAGGTCCCCAAATGATCTTACTCCATGCCCCACCCGCTCACACCGTCCTTTCCCGTCACCCTTGCTATCCCCTGGA
GCACTGCCCTCCAGAGCTGCCCTTCCCAGGAAGGAATTTGGTTGGATTCTGTCACTGTGGAGACCAAGATTTTTTAAAATTCCCAATTAC
AAAAGCAGCATCACACTTGCTTCTGAGAACAGCAGGGTGATGTCTGTTCCCAAGCTGGTGGCGGGAGCCTTAGCCTGTGTGGGGCCACCC
GGGGAAGAGGAGGAGAGGAGGGTGAGGAGGCAGGCTCGCCGTTCCAAGGGACAGCATAGGCTCGTGGTGGGGCGTGTTGCATCTGGTGTC
TGGGACAGTCCCCGTCACCCCATGTGTGCGGCCTCTGCACTCCCAAGCTCCATGGCTGGGCTGGGCTGGGCTGGGCTGGGCTGGGCCGGG
CGTGCGGAGCCTGTGGAGCCAGCAGCTGCAGAGGCCTAGGAGGGAGTTCCTGGGGGAAGCGCACAGTGTCCAGTGCCCATCTCTTGCTTG
TGTGTGAGATTAGCCCTTGCTGGGGCGTCAAGAGGAAGAGCCTTAGACCTGGGCGGGCCTTCAGGGGCATCTAGACCCCTGCACAGCCCA
GGCCTGGTGTCTGCATTTCCACAGCACCCCTGTGGGGACTCCTGCCGGGGCTGGCCGCTGTCTCAGGAGAGACCCAATGGTTAGAAAGCC
CCTTTTTACACAGCTGACAGCTTCTCCCAAGGCTTCCGTCCACGGGGACAGGCTTAACCCCTGGGCGCCTTTTCTGCAGCATGGCGGCCT
TCTGAGTCACCTAAGCTGAGCCTGGGTCATTCTCTGTGGCGGTCAGAAGGCCGATGGCCCCAACACAGTGGCTTGTGAAAGGGAGAGAGG
AGGCTCTGCATGTCCACCTGCTCTATGGGAGGAGGACACAGGTGTCCCCAGCCCAGCCTGTTCTCTCCCAGTCACTCAGGGATGGGGCCA
CCCAAAGTGCAGGACCCGCCCCACCCTGCGGTTCGAAGCCTGGCCCCTGTCTCCACTTAGCTTCTGTTTCTGCAGTGGGTGGAAGCGAGT
CAGCGGGGGGCCTGGCTTGTGTACGTGTTTTCCTTATTTGGTCTGTGGGTTGCCAAGTCCATTTTTTTTTCCACTGAACTGGCTGGTAAC
TTGATGGACTGTGTAACTGACACAGGCCCTCTTTAGACCCCTGCCTTCACCCCACCCGCCCGGGTCCACTCCCTGGGGCGCTGTCCCAAG
CCATCCCTGCTTGCCAGCTCAAAGCTTCAGGTCCTAGGAGCCAGTCCACCTCGAAAGCCCTGAGAAAGTGAGACACCTGCACATTCGCTG
GGGGAGACCCTCCGTTCTCTTGTGGCAGCTGCTCCCACTTGTTAAACCAAGCTGTTTCTGCGGGACGTGCTCACTCTTGGGAACCAGTGG
CCTAGAGCTTTGGGTTACAGGCATGGAGAGGGCTTTCCTGCCTCAGGCTTGGAGGCCAATGTTCCATACATAAACCGCCATGTCCTCTGG
TGCAGCTGGGCTGCTCTTTTAAAAGCCAGCATCCATCTTGAAGCTCGCTGGGTAAATGGCAATGCATTCTCAAGCCAGTGTCTTCAGCTG
ATGCCCAGTGTCCAGTGCTGGTCACCAGTCCCCTTTGCTGGGTACAGCCTGCCTGGCTGTTCTGTGGTCCTGGAACGCTGCAGTGTGGTT
TTGTTCCATGGAGACAGTACCAAGCGGAGAGGCCTCCTTGCCCACGGCCCCAGGGCCTGGGGGCCAGGGGTTCTGGCCCTGCGGGGACTT
AGGCAGGAGGGGAAGAGAAGCCCATGGAGCCATGGGAGGGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGGCGGGG
CGAGCTGTGGGTGGGGCCTAGCCATGGGAGAGGTGAGCTGTGAATGGGGCTAGCTATGGGTGGGGTGAGCTGTGGACAGGGCCTAGCCAT
GGGAAAGGTGAGCTGTGGGCGGGGCCTAGTCACGGGAGAGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGATGGGG
CCTAGCCATGGGAGGGGTGAGCTGTGAGTGGGGCTGAGCCATGGGAGCAGCAAGCTGGTGGAGTGGGCTGGGCGGAGCTGTGGGGGCTGC
TGGCAGGGCCTAGGAAAGTAGACAACTCCCGGGGGAGACGAAGTAGAGAGTGAGTCCCCAAGAAAGGGACTCCTGCCCCAGCGTCAAGTG
CCAAAGCAGGCCCCATCTACCACTTCAGGGTCGACGTTGGTGGCAGGTGTTGTTCACGGTGTACTGATTGTCACTGCAACACCTCCACAT
CACCTTGAACTTCAAGAACAGCAGCAAAGCTGTATCTGCTATCAGAGGCTGTTAGGTAGTCCAGCTTTAAAATAACACACTCTTTCTCTA
TCCCATGCCCTTTAAACAAGCAGCCACAGGAGATGTCAGTCTCCAGGGCCTGGCCCCACTGTGTTGACAGCAGTCACGTCTGTTGAGCTG
ACACTGCTGAGGCTGAAGCTGGCCCCGTGCAGGTGGCTGGTGAGCCACAGGTGCAGTACCCGGAGGTGTGCTCTCCCCTAGAGGCCTGTC
CCCAACTCCTCCCCTAGAGGCCTATTCCCGCTGCTCACAGACCTCAGCAGAGGCACCAGCTGGAGGGCTCCAGGGACATCCTTGGAGATA
CAGGAGGCTTTCCTGGCACAGGGCACAGCTCTTAGGAGGCCTTTGTAGGACGCTGTCTCCCCAGCGTGTCCTGCTCATCCAGGATGGGGA
GAAAGAGGAGGAGGCCCCAGGCTCAGAAGCCAGGGACAGACTGCCGACGATTACCAAACTGAATCCAGGCAGTGCCATGACCCTGGGTGT
CCCTTGGTTCACATCACCCACCAGACAGCTGCGGAGAGAGTGCAGGGAGGGGCTGGGACCAAACAGGCCAGAAACCAGCAGAAAAGAGGC
AGAAGTGAGGTGGGTGTGCCTGGGGCACGAAGCCAGCGCCGGGGGGATTTCAGTGGAGCCTTACAGCCAGGCTCCGTGCGGACTGTGATG
CCAGAGAGGCGTGCAGCCTCTGGGCAAGTCGGGAGAGGGCTTGGGTGGTCCCCACAAGGCAGAAGAGGTGGAAGGGCCAGAGAAGACCAC
CAAGACCACCGTTCCCGCAGGCCTGGGGTGAGTGACCTGACTGAGACTAGCGGGCAGAGCCAAGCAGGGCTAAACTCCAACCCAGGGCCC
GGTGTTGGACAAAGTAGCTTTTTCTTTGCTCGTTTGTCTGTGTATTAAGAAGAGACTAAAATAGCCAAACGACGCTGGTCGCATGCGCTG
GCTGTGGTCTGTCTGCTGAATGTCTATTTTTGTCTCCTGACGAGACGTGAGGACCATGCCCTTGATCCCTCCGATGGACCAGAAACCCCC
TTCCTTGCAAAAAAAAGGCAATTGAATTAGGAAAAGATAGCCCAACCTAGCTCAGATCCACCAAGATAAGCACAGCAAAGCTTGGCTGCA
TTTTTGAGGAATAAAAACCTGCAGAAAGCACCGATAACCTTCAAGATCTGAATGAGATTCTATTATAACCCGTCTAAACGATTGCAAAAT
TCCTCCTTTGGTTTTGGAAGCAGCGTTTGCTCTCCCGTGGCTCGGATTCTCTGAGGACCAGGGAGTTGACACACAAACCCCGCCATGGGT
CCGAGCCAGCTATTTCTCAAGGCTCCCACCTCGCCAAGCTCCCAAGGGCCTGCTGGCAGTGCCTACGCTGTGCCAACTACCCTGTCTGGT
ACAGACCACGGCTGGGTAAGCACCCTTAAAAGCAACAGAAATGACGTCTGGAAGCTGAAATGTGAAACTGTCAAGATGGCTTAGGAGAGG
AAGGAGTGGACCCGCTGGTCTTTGGCATTTTGTATTTAGAATTATTCTAACTTTATACATAATGTATAGGCCGATCTTTTGGAAGGGATA

>In-frame_ENST00000586638_ENST00000404984_TCGA-86-A4P7-01A_APOC1_chr19_45422606_-_IQCE_chr7_2641075_length(amino acids)=174AA_start in transcript=3605_stop in transcript=3081
MPAAPTAPPSPLHQLAAPMAQPHSQLTPPMARPHPQLTPPMTRPRPQLTSPVTRPRPQLTFPMARPCPQLTPPIASPIHSSPLPWLGPTH

--------------------------------------------------------------
>In-frame_ENST00000586638_ENST00000402050_TCGA-86-A4P7-01A_APOC1_chr19_45422606_-_IQCE_chr7_2641075_length(transcript)=5477nt_BP=425nt
CAGAGTGCCCCTCCGGCCTCGCCATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCC
CAGCCCAGGGGACCCCAGACGTCTCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCA
GCCGCATCAAACAGAGTGAACTTTCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACA
TTTCAGAAAGTGAAGGAGAAACTCAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCC
AGCGCCTGTGCTGAGGACTCCCTCCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGG
CGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCG
TGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCA
TCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCA
GGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGG
CCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCCGACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAG
TTTAGGTCCCCGTCACTGTCTCCACGCCGTGATGGCAGCGCTGCCGAGGACATAGGAACCACGACTGGAAAGATAATTTATCGTGTTAGG
AGAAGAACGATGATACCTACTTAACACCTCAGCATCTGCGTCGTGTCTCTTTGTGCTTTTGTTTGTGGAAGGAGACCCAAATGCCTTTAC
TTTATTCTCTGGGGAGGGCCAGCGGCTCGCATCCCCCTCATCTCCAGCTGCAGCTCGGATGGTGGATTTTCAGTGCCAACAGACACATCT
GCCGTGAACTCGCAGATGCCAGGGAGCCCTGTAGTGACACGTTCTCTGACAGCACCTTGCCGCCTGCCCACGACCTTGACCGTGAGGAGC
TGCTATCCGCAACCAGCGCCGACACCATGCCCCCTCTTCCTGGTGACACCCTCAACAACCAGGATTTGCTCGATCTCAGCCCAGCAGGCC
AGGCAGACACACCCCGCTGTGCCTTAGGAAGGTGTGAGACCGGCTTCCCCCATCCCCACAGCAAAACACGGCCTGTCCCAAGCCAGTGAG
GAGCTAAAGACACCCAGGTCCCCAAATGATCTTACTCCATGCCCCACCCGCTCACACCGTCCTTTCCCGTCACCCTTGCTATCCCCTGGA
GCACTGCCCTCCAGAGCTGCCCTTCCCAGGAAGGAATTTGGTTGGATTCTGTCACTGTGGAGACCAAGATTTTTTAAAATTCCCAATTAC
AAAAGCAGCATCACACTTGCTTCTGAGAACAGCAGGGTGATGTCTGTTCCCAAGCTGGTGGCGGGAGCCTTAGCCTGTGTGGGGCCACCC
GGGGAAGAGGAGGAGAGGAGGGTGAGGAGGCAGGCTCGCCGTTCCAAGGGACAGCATAGGCTCGTGGTGGGGCGTGTTGCATCTGGTGTC
TGGGACAGTCCCCGTCACCCCATGTGTGCGGCCTCTGCACTCCCAAGCTCCATGGCTGGGCTGGGCTGGGCTGGGCTGGGCTGGGCCGGG
CGTGCGGAGCCTGTGGAGCCAGCAGCTGCAGAGGCCTAGGAGGGAGTTCCTGGGGGAAGCGCACAGTGTCCAGTGCCCATCTCTTGCTTG
TGTGTGAGATTAGCCCTTGCTGGGGCGTCAAGAGGAAGAGCCTTAGACCTGGGCGGGCCTTCAGGGGCATCTAGACCCCTGCACAGCCCA
GGCCTGGTGTCTGCATTTCCACAGCACCCCTGTGGGGACTCCTGCCGGGGCTGGCCGCTGTCTCAGGAGAGACCCAATGGTTAGAAAGCC
CCTTTTTACACAGCTGACAGCTTCTCCCAAGGCTTCCGTCCACGGGGACAGGCTTAACCCCTGGGCGCCTTTTCTGCAGCATGGCGGCCT
TCTGAGTCACCTAAGCTGAGCCTGGGTCATTCTCTGTGGCGGTCAGAAGGCCGATGGCCCCAACACAGTGGCTTGTGAAAGGGAGAGAGG
AGGCTCTGCATGTCCACCTGCTCTATGGGAGGAGGACACAGGTGTCCCCAGCCCAGCCTGTTCTCTCCCAGTCACTCAGGGATGGGGCCA
CCCAAAGTGCAGGACCCGCCCCACCCTGCGGTTCGAAGCCTGGCCCCTGTCTCCACTTAGCTTCTGTTTCTGCAGTGGGTGGAAGCGAGT
CAGCGGGGGGCCTGGCTTGTGTACGTGTTTTCCTTATTTGGTCTGTGGGTTGCCAAGTCCATTTTTTTTTCCACTGAACTGGCTGGTAAC
TTGATGGACTGTGTAACTGACACAGGCCCTCTTTAGACCCCTGCCTTCACCCCACCCGCCCGGGTCCACTCCCTGGGGCGCTGTCCCAAG
CCATCCCTGCTTGCCAGCTCAAAGCTTCAGGTCCTAGGAGCCAGTCCACCTCGAAAGCCCTGAGAAAGTGAGACACCTGCACATTCGCTG
GGGGAGACCCTCCGTTCTCTTGTGGCAGCTGCTCCCACTTGTTAAACCAAGCTGTTTCTGCGGGACGTGCTCACTCTTGGGAACCAGTGG
CCTAGAGCTTTGGGTTACAGGCATGGAGAGGGCTTTCCTGCCTCAGGCTTGGAGGCCAATGTTCCATACATAAACCGCCATGTCCTCTGG
TGCAGCTGGGCTGCTCTTTTAAAAGCCAGCATCCATCTTGAAGCTCGCTGGGTAAATGGCAATGCATTCTCAAGCCAGTGTCTTCAGCTG
ATGCCCAGTGTCCAGTGCTGGTCACCAGTCCCCTTTGCTGGGTACAGCCTGCCTGGCTGTTCTGTGGTCCTGGAACGCTGCAGTGTGGTT
TTGTTCCATGGAGACAGTACCAAGCGGAGAGGCCTCCTTGCCCACGGCCCCAGGGCCTGGGGGCCAGGGGTTCTGGCCCTGCGGGGACTT
AGGCAGGAGGGGAAGAGAAGCCCATGGAGCCATGGGAGGGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGGCGGGG
CGAGCTGTGGGTGGGGCCTAGCCATGGGAGAGGTGAGCTGTGAATGGGGCTAGCTATGGGTGGGGTGAGCTGTGGACAGGGCCTAGCCAT
GGGAAAGGTGAGCTGTGGGCGGGGCCTAGTCACGGGAGAGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGATGGGG
CCTAGCCATGGGAGGGGTGAGCTGTGAGTGGGGCTGAGCCATGGGAGCAGCAAGCTGGTGGAGTGGGCTGGGCGGAGCTGTGGGGGCTGC
TGGCAGGGCCTAGGAAAGTAGACAACTCCCGGGGGAGACGAAGTAGAGAGTGAGTCCCCAAGAAAGGGACTCCTGCCCCAGCGTCAAGTG
CCAAAGCAGGCCCCATCTACCACTTCAGGGTCGACGTTGGTGGCAGGTGTTGTTCACGGTGTACTGATTGTCACTGCAACACCTCCACAT
CACCTTGAACTTCAAGAACAGCAGCAAAGCTGTATCTGCTATCAGAGGCTGTTAGGTAGTCCAGCTTTAAAATAACACACTCTTTCTCTA
TCCCATGCCCTTTAAACAAGCAGCCACAGGAGATGTCAGTCTCCAGGGCCTGGCCCCACTGTGTTGACAGCAGTCACGTCTGTTGAGCTG
ACACTGCTGAGGCTGAAGCTGGCCCCGTGCAGGTGGCTGGTGAGCCACAGGTGCAGTACCCGGAGGTGTGCTCTCCCCTAGAGGCCTGTC
CCCAACTCCTCCCCTAGAGGCCTATTCCCGCTGCTCACAGACCTCAGCAGAGGCACCAGCTGGAGGGCTCCAGGGACATCCTTGGAGATA
CAGGAGGCTTTCCTGGCACAGGGCACAGCTCTTAGGAGGCCTTTGTAGGACGCTGTCTCCCCAGCGTGTCCTGCTCATCCAGGATGGGGA
GAAAGAGGAGGAGGCCCCAGGCTCAGAAGCCAGGGACAGACTGCCGACGATTACCAAACTGAATCCAGGCAGTGCCATGACCCTGGGTGT
CCCTTGGTTCACATCACCCACCAGACAGCTGCGGAGAGAGTGCAGGGAGGGGCTGGGACCAAACAGGCCAGAAACCAGCAGAAAAGAGGC
AGAAGTGAGGTGGGTGTGCCTGGGGCACGAAGCCAGCGCCGGGGGGATTTCAGTGGAGCCTTACAGCCAGGCTCCGTGCGGACTGTGATG
CCAGAGAGGCGTGCAGCCTCTGGGCAAGTCGGGAGAGGGCTTGGGTGGTCCCCACAAGGCAGAAGAGGTGGAAGGGCCAGAGAAGACCAC
CAAGACCACCGTTCCCGCAGGCCTGGGGTGAGTGACCTGACTGAGACTAGCGGGCAGAGCCAAGCAGGGCTAAACTCCAACCCAGGGCCC
GGTGTTGGACAAAGTAGCTTTTTCTTTGCTCGTTTGTCTGTGTATTAAGAAGAGACTAAAATAGCCAAACGACGCTGGTCGCATGCGCTG
GCTGTGGTCTGTCTGCTGAATGTCTATTTTTGTCTCCTGACGAGACGTGAGGACCATGCCCTTGATCCCTCCGATGGACCAGAAACCCCC
TTCCTTGCAAAAAAAAGGCAATTGAATTAGGAAAAGATAGCCCAACCTAGCTCAGATCCACCAAGATAAGCACAGCAAAGCTTGGCTGCA
TTTTTGAGGAATAAAAACCTGCAGAAAGCACCGATAACCTTCAAGATCTGAATGAGATTCTATTATAACCCGTCTAAACGATTGCAAAAT
TCCTCCTTTGGTTTTGGAAGCAGCGTTTGCTCTCCCGTGGCTCGGATTCTCTGAGGACCAGGGAGTTGACACACAAACCCCGCCATGGGT
CCGAGCCAGCTATTTCTCAAGGCTCCCACCTCGCCAAGCTCCCAAGGGCCTGCTGGCAGTGCCTACGCTGTGCCAACTACCCTGTCTGGT
ACAGACCACGGCTGGGTAAGCACCCTTAAAAGCAACAGAAATGACGTCTGGAAGCTGAAATGTGAAACTGTCAAGATGGCTTAGGAGAGG
AAGGAGTGGACCCGCTGGTCTTTGGCATTTTGTATTTAGAATTATTCTAACTTTATACATAATGTATAGGCCGATCTTTTGGAAGGGATA

>In-frame_ENST00000586638_ENST00000402050_TCGA-86-A4P7-01A_APOC1_chr19_45422606_-_IQCE_chr7_2641075_length(amino acids)=174AA_start in transcript=3605_stop in transcript=3081
MPAAPTAPPSPLHQLAAPMAQPHSQLTPPMARPHPQLTPPMTRPRPQLTSPVTRPRPQLTFPMARPCPQLTPPIASPIHSSPLPWLGPTH

--------------------------------------------------------------
>In-frame_ENST00000586638_ENST00000438376_TCGA-86-A4P7-01A_APOC1_chr19_45422606_-_IQCE_chr7_2641075_length(transcript)=905nt_BP=425nt
CAGAGTGCCCCTCCGGCCTCGCCATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCC
CAGCCCAGGGGACCCCAGACGTCTCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCA
GCCGCATCAAACAGAGTGAACTTTCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACA
TTTCAGAAAGTGAAGGAGAAACTCAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCC
AGCGCCTGTGCTGAGGACTCCCTCCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGG
CGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCG
TGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCA
TCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCA
GGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGG
CCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCCGACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAG

>In-frame_ENST00000586638_ENST00000438376_TCGA-86-A4P7-01A_APOC1_chr19_45422606_-_IQCE_chr7_2641075_length(amino acids)=155AA_start in transcript=440_stop in transcript=904
MDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHLARARHSATGKRTTTA

--------------------------------------------------------------
>In-frame_ENST00000586638_ENST00000325979_TCGA-86-A4P7-01A_APOC1_chr19_45422606_-_IQCE_chr7_2641075_length(transcript)=905nt_BP=425nt
CAGAGTGCCCCTCCGGCCTCGCCATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCC
CAGCCCAGGGGACCCCAGACGTCTCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCA
GCCGCATCAAACAGAGTGAACTTTCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACA
TTTCAGAAAGTGAAGGAGAAACTCAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCC
AGCGCCTGTGCTGAGGACTCCCTCCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGG
CGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCG
TGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCA
TCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCA
GGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGG
CCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCCGACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAG

>In-frame_ENST00000586638_ENST00000325979_TCGA-86-A4P7-01A_APOC1_chr19_45422606_-_IQCE_chr7_2641075_length(amino acids)=155AA_start in transcript=440_stop in transcript=904
MDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHLARARHSATGKRTTTA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for APOC1-IQCE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APOC1-IQCE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APOC1-IQCE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPOC1C0002395Alzheimer's Disease2CTD_human
HgeneAPOC1C0011265Presenile dementia2CTD_human
HgeneAPOC1C0276496Familial Alzheimer Disease (FAD)2CTD_human
HgeneAPOC1C0494463Alzheimer Disease, Late Onset2CTD_human
HgeneAPOC1C0546126Acute Confusional Senile Dementia2CTD_human
HgeneAPOC1C0750900Alzheimer's Disease, Focal Onset2CTD_human
HgeneAPOC1C0750901Alzheimer Disease, Early Onset2CTD_human
HgeneAPOC1C0018801Heart failure1CTD_human
HgeneAPOC1C0018802Congestive heart failure1CTD_human
HgeneAPOC1C0023212Left-Sided Heart Failure1CTD_human
HgeneAPOC1C0235527Heart Failure, Right-Sided1CTD_human
HgeneAPOC1C1959583Myocardial Failure1CTD_human
HgeneAPOC1C1961112Heart Decompensation1CTD_human
TgeneIQCEC3887487Postaxial polydactyly type A2ORPHANET
TgeneIQCEC4539976POLYDACTYLY, POSTAXIAL, TYPE A71GENOMICS_ENGLAND