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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NADSYN1-GSTP1 (FusionGDB2 ID:56782)

Fusion Gene Summary for NADSYN1-GSTP1

check button Fusion gene summary
Fusion gene informationFusion gene name: NADSYN1-GSTP1
Fusion gene ID: 56782
HgeneTgene
Gene symbol

NADSYN1

GSTP1

Gene ID

55191

2950

Gene nameNAD synthetase 1glutathione S-transferase pi 1
Synonyms-DFN7|FAEES3|GST3|GSTP|HEL-S-22|PI
Cytomap

11q13.4

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionglutamine-dependent NAD(+) synthetaseNAD(+) synthaseNAD(+) synthetaseglutamine-dependent NAD synthetaseglutathione S-transferase PGST class-piGSTP1-1deafness, X-linked 7epididymis secretory protein Li 22fatty acid ethyl ester synthase III
Modification date2020031320200329
UniProtAcc.

P09211

Ensembl transtripts involved in fusion geneENST00000319023, ENST00000539574, 
ENST00000530055, ENST00000526039, 
ENST00000398606, ENST00000398603, 
ENST00000498765, 
Fusion gene scores* DoF score14 X 13 X 7=12745 X 4 X 5=100
# samples 175
** MAII scorelog2(17/1274*10)=-2.9057586261186
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NADSYN1 [Title/Abstract] AND GSTP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNADSYN1(71169590)-GSTP1(67352156), # samples:1
Anticipated loss of major functional domain due to fusion event.NADSYN1-GSTP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NADSYN1-GSTP1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NADSYN1-GSTP1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NADSYN1-GSTP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGSTP1

GO:0006469

negative regulation of protein kinase activity

16636664

TgeneGSTP1

GO:0006749

glutathione metabolic process

1540159

TgeneGSTP1

GO:0006805

xenobiotic metabolic process

1540159

TgeneGSTP1

GO:0009890

negative regulation of biosynthetic process

18962899

TgeneGSTP1

GO:0032691

negative regulation of interleukin-1 beta production

18962899

TgeneGSTP1

GO:0032720

negative regulation of tumor necrosis factor production

18962899

TgeneGSTP1

GO:0043407

negative regulation of MAP kinase activity

11408560

TgeneGSTP1

GO:0043508

negative regulation of JUN kinase activity

16636664

TgeneGSTP1

GO:0043651

linoleic acid metabolic process

16624487

TgeneGSTP1

GO:0051771

negative regulation of nitric-oxide synthase biosynthetic process

18962899

TgeneGSTP1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

11408560

TgeneGSTP1

GO:0071638

negative regulation of monocyte chemotactic protein-1 production

18962899

TgeneGSTP1

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

16636664


check buttonFusion gene breakpoints across NADSYN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GSTP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-5247-01ANADSYN1chr11

71169590

+GSTP1chr11

67352156

+


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Fusion Gene ORF analysis for NADSYN1-GSTP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000319023ENST00000398606NADSYN1chr11

71169590

+GSTP1chr11

67352156

+
Frame-shiftENST00000319023ENST00000398603NADSYN1chr11

71169590

+GSTP1chr11

67352156

+
5CDS-3UTRENST00000319023ENST00000498765NADSYN1chr11

71169590

+GSTP1chr11

67352156

+
intron-3CDSENST00000539574ENST00000398606NADSYN1chr11

71169590

+GSTP1chr11

67352156

+
intron-3CDSENST00000539574ENST00000398603NADSYN1chr11

71169590

+GSTP1chr11

67352156

+
intron-3UTRENST00000539574ENST00000498765NADSYN1chr11

71169590

+GSTP1chr11

67352156

+
intron-3CDSENST00000530055ENST00000398606NADSYN1chr11

71169590

+GSTP1chr11

67352156

+
intron-3CDSENST00000530055ENST00000398603NADSYN1chr11

71169590

+GSTP1chr11

67352156

+
intron-3UTRENST00000530055ENST00000498765NADSYN1chr11

71169590

+GSTP1chr11

67352156

+
intron-3CDSENST00000526039ENST00000398606NADSYN1chr11

71169590

+GSTP1chr11

67352156

+
intron-3CDSENST00000526039ENST00000398603NADSYN1chr11

71169590

+GSTP1chr11

67352156

+
intron-3UTRENST00000526039ENST00000498765NADSYN1chr11

71169590

+GSTP1chr11

67352156

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NADSYN1-GSTP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NADSYN1chr1171169590+GSTP1chr1167352155+0.0017372030.9982628
NADSYN1chr1171169590+GSTP1chr1167352155+0.0017372030.9982628

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NADSYN1-GSTP1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GSTP1

P09211

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NADSYN1-GSTP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NADSYN1-GSTP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NADSYN1-GSTP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGSTP1P09211DB00363ClozapineSmall moleculeApproved
TgeneGSTP1P09211DB00363ClozapineSmall moleculeApproved
TgeneGSTP1P09211DB00363ClozapineSmall moleculeApproved
TgeneGSTP1P09211DB03619Deoxycholic acidSmall moleculeApproved
TgeneGSTP1P09211DB03619Deoxycholic acidSmall moleculeApproved
TgeneGSTP1P09211DB03619Deoxycholic acidSmall moleculeApproved
TgeneGSTP1P09211DB11672CurcuminSmall moleculeApproved|Experimental|Investigational
TgeneGSTP1P09211DB11672CurcuminSmall moleculeApproved|Experimental|Investigational
TgeneGSTP1P09211DB11672CurcuminSmall moleculeApproved|Experimental|Investigational
TgeneGSTP1P09211DB00903Etacrynic acidInhibitorSmall moleculeApproved|Investigational
TgeneGSTP1P09211DB00903Etacrynic acidInhibitorSmall moleculeApproved|Investigational
TgeneGSTP1P09211DB00903Etacrynic acidInhibitorSmall moleculeApproved|Investigational
TgeneGSTP1P09211DB04339CarbocisteineSmall moleculeApproved|Investigational
TgeneGSTP1P09211DB04339CarbocisteineSmall moleculeApproved|Investigational
TgeneGSTP1P09211DB04339CarbocisteineSmall moleculeApproved|Investigational
TgeneGSTP1P09211DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical
TgeneGSTP1P09211DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical
TgeneGSTP1P09211DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical
TgeneGSTP1P09211DB01242ClomipramineInhibitorSmall moleculeApproved|Investigational|Vet_approved
TgeneGSTP1P09211DB01242ClomipramineInhibitorSmall moleculeApproved|Investigational|Vet_approved
TgeneGSTP1P09211DB01242ClomipramineInhibitorSmall moleculeApproved|Investigational|Vet_approved
TgeneGSTP1P09211DB00197TroglitazoneSmall moleculeApproved|Investigational|Withdrawn
TgeneGSTP1P09211DB00197TroglitazoneSmall moleculeApproved|Investigational|Withdrawn
TgeneGSTP1P09211DB00197TroglitazoneSmall moleculeApproved|Investigational|Withdrawn

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Related Diseases for NADSYN1-GSTP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNADSYN1C0000772Multiple congenital anomalies1GENOMICS_ENGLAND
HgeneNADSYN1C0426706Absent kidney1GENOMICS_ENGLAND
TgeneGSTP1C0032927Precancerous Conditions6CTD_human
TgeneGSTP1C0282313Condition, Preneoplastic6CTD_human
TgeneGSTP1C0033578Prostatic Neoplasms5CTD_human
TgeneGSTP1C0376358Malignant neoplasm of prostate5CTD_human
TgeneGSTP1C0004096Asthma4CTD_human
TgeneGSTP1C0019207Hepatoma, Morris4CTD_human
TgeneGSTP1C0019208Hepatoma, Novikoff4CTD_human
TgeneGSTP1C0023904Liver Neoplasms, Experimental4CTD_human
TgeneGSTP1C0086404Experimental Hepatoma4CTD_human
TgeneGSTP1C0005684Malignant neoplasm of urinary bladder3CTD_human
TgeneGSTP1C0005695Bladder Neoplasm3CTD_human
TgeneGSTP1C0019193Hepatitis, Toxic2CTD_human
TgeneGSTP1C0024623Malignant neoplasm of stomach2CTD_human
TgeneGSTP1C0030567Parkinson Disease2CTD_human
TgeneGSTP1C0036341Schizophrenia2PSYGENET
TgeneGSTP1C0038356Stomach Neoplasms2CTD_human
TgeneGSTP1C0860207Drug-Induced Liver Disease2CTD_human
TgeneGSTP1C1262760Hepatitis, Drug-Induced2CTD_human
TgeneGSTP1C1708349Hereditary Diffuse Gastric Cancer2CTD_human
TgeneGSTP1C3658290Drug-Induced Acute Liver Injury2CTD_human
TgeneGSTP1C4277682Chemical and Drug Induced Liver Injury2CTD_human
TgeneGSTP1C4279912Chemically-Induced Liver Toxicity2CTD_human
TgeneGSTP1C0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneGSTP1C0004352Autistic Disorder1CTD_human
TgeneGSTP1C0004403Autosome Abnormalities1CTD_human
TgeneGSTP1C0006142Malignant neoplasm of breast1CTD_human
TgeneGSTP1C0007097Carcinoma1CTD_human
TgeneGSTP1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneGSTP1C0007134Renal Cell Carcinoma1CTD_human
TgeneGSTP1C0007273Carotid Artery Diseases1CTD_human
TgeneGSTP1C0008625Chromosome Aberrations1CTD_human
TgeneGSTP1C0011616Contact Dermatitis1CTD_human
TgeneGSTP1C0013182Drug Allergy1CTD_human
TgeneGSTP1C0017638Glioma1CTD_human
TgeneGSTP1C0019829Hodgkin Disease1CTD_human
TgeneGSTP1C0020538Hypertensive disease1CTD_human
TgeneGSTP1C0022650Kidney Calculi1CTD_human
TgeneGSTP1C0022658Kidney Diseases1CTD_human
TgeneGSTP1C0022660Kidney Failure, Acute1CTD_human
TgeneGSTP1C0023473Myeloid Leukemia, Chronic1CTD_human
TgeneGSTP1C0024121Lung Neoplasms1CTD_human
TgeneGSTP1C0027540Necrosis1CTD_human
TgeneGSTP1C0029463Osteosarcoma1CTD_human
TgeneGSTP1C0032230Pleural Rub1CTD_human
TgeneGSTP1C0033937Psychoses, Drug1CTD_human
TgeneGSTP1C0033941Psychoses, Substance-Induced1CTD_human
TgeneGSTP1C0033975Psychotic Disorders1PSYGENET
TgeneGSTP1C0034642Rales1CTD_human
TgeneGSTP1C0035234Respiratory Sounds1CTD_human
TgeneGSTP1C0035508Rhonchi1CTD_human
TgeneGSTP1C0036939Shared Paranoid Disorder1PSYGENET
TgeneGSTP1C0038450Stridor1CTD_human
TgeneGSTP1C0042594Vestibular Diseases1CTD_human
TgeneGSTP1C0043144Wheezing1CTD_human
TgeneGSTP1C0151744Myocardial Ischemia1CTD_human
TgeneGSTP1C0152266Mixed Cellularity Hodgkin Lymphoma1CTD_human
TgeneGSTP1C0152267Hodgkin lymphoma, lymphocyte depletion1CTD_human
TgeneGSTP1C0162351Contact hypersensitivity1CTD_human
TgeneGSTP1C0205696Anaplastic carcinoma1CTD_human
TgeneGSTP1C0205697Carcinoma, Spindle-Cell1CTD_human
TgeneGSTP1C0205698Undifferentiated carcinoma1CTD_human
TgeneGSTP1C0205699Carcinomatosis1CTD_human
TgeneGSTP1C0205944Sarcoma, Epithelioid1CTD_human
TgeneGSTP1C0205945Sarcoma, Spindle Cell1CTD_human
TgeneGSTP1C0220597Adult Hodgkin Lymphoma1CTD_human
TgeneGSTP1C0235874Disease Exacerbation1CTD_human
TgeneGSTP1C0236733Amphetamine-Related Disorders1CTD_human
TgeneGSTP1C0236804Amphetamine Addiction1CTD_human
TgeneGSTP1C0236807Amphetamine Abuse1CTD_human
TgeneGSTP1C0242379Malignant neoplasm of lung1CTD_human
TgeneGSTP1C0259783mixed gliomas1CTD_human
TgeneGSTP1C0270736Essential Tremor1CTD_human
TgeneGSTP1C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneGSTP1C0282612Prostatic Intraepithelial Neoplasias1CTD_human
TgeneGSTP1C0349204Nonorganic psychosis1PSYGENET
TgeneGSTP1C0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneGSTP1C0393615Familial Tremor1CTD_human
TgeneGSTP1C0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgeneGSTP1C0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneGSTP1C0555198Malignant Glioma1CTD_human
TgeneGSTP1C0577631Carotid Atherosclerosis1CTD_human
TgeneGSTP1C0600178External Carotid Artery Diseases1CTD_human
TgeneGSTP1C0600427Cocaine Dependence1PSYGENET
TgeneGSTP1C0678222Breast Carcinoma1CTD_human
TgeneGSTP1C0750986Internal Carotid Artery Diseases1CTD_human
TgeneGSTP1C0750987Arterial Diseases, Common Carotid1CTD_human
TgeneGSTP1C0948089Acute Coronary Syndrome1CTD_human
TgeneGSTP1C1257931Mammary Neoplasms, Human1CTD_human
TgeneGSTP1C1261473Sarcoma1CTD_human
TgeneGSTP1C1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneGSTP1C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneGSTP1C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneGSTP1C1266194Lymphocyte Rich Classical Hodgkin Lymphoma1CTD_human
TgeneGSTP1C1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneGSTP1C1334968Nodular Lymphocyte Predominant Hodgkin Lymphoma1CTD_human
TgeneGSTP1C1456865Ureteral Calculi1CTD_human
TgeneGSTP1C1458155Mammary Neoplasms1CTD_human
TgeneGSTP1C1565662Acute Kidney Insufficiency1CTD_human
TgeneGSTP1C2239176Liver carcinoma1CTD_human
TgeneGSTP1C2609414Acute kidney injury1CTD_human
TgeneGSTP1C3241937Nonalcoholic Steatohepatitis1CTD_human
TgeneGSTP1C4704874Mammary Carcinoma, Human1CTD_human
TgeneGSTP1C4721453Peripheral Nervous System Diseases1CTD_human