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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:NADSYN1-PPP6R3 (FusionGDB2 ID:56790) |
Fusion Gene Summary for NADSYN1-PPP6R3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: NADSYN1-PPP6R3 | Fusion gene ID: 56790 | Hgene | Tgene | Gene symbol | NADSYN1 | PPP6R3 | Gene ID | 55191 | 55291 |
Gene name | NAD synthetase 1 | protein phosphatase 6 regulatory subunit 3 | |
Synonyms | - | C11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3 | |
Cytomap | 11q13.4 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | glutamine-dependent NAD(+) synthetaseNAD(+) synthaseNAD(+) synthetaseglutamine-dependent NAD synthetase | serine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000319023, ENST00000539574, ENST00000530055, ENST00000526039, | ENST00000393799, ENST00000530427, ENST00000393800, ENST00000534534, ENST00000524845, ENST00000265637, ENST00000524904, ENST00000393801, ENST00000265636, ENST00000529710, ENST00000527403, | |
Fusion gene scores | * DoF score | 14 X 13 X 7=1274 | 28 X 32 X 13=11648 |
# samples | 17 | 38 | |
** MAII score | log2(17/1274*10)=-2.9057586261186 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(38/11648*10)=-4.93793903186775 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NADSYN1 [Title/Abstract] AND PPP6R3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | NADSYN1(71189515)-PPP6R3(68321613), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PPP6R3 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 16716191 |
Fusion gene breakpoints across NADSYN1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across PPP6R3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SKCM | TCGA-D9-A3Z3-06A | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
ChimerDB4 | SKCM | TCGA-D9-A3Z3-06A | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
ChimerDB4 | SKCM | TCGA-D9-A3Z3-06A | NADSYN1 | chr11 | 71189515 | - | PPP6R3 | chr11 | 68321613 | + |
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Fusion Gene ORF analysis for NADSYN1-PPP6R3 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000319023 | ENST00000393799 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000319023 | ENST00000530427 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000319023 | ENST00000393800 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000319023 | ENST00000534534 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000319023 | ENST00000524845 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000319023 | ENST00000265637 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000319023 | ENST00000524904 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000319023 | ENST00000393801 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000319023 | ENST00000265636 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000319023 | ENST00000529710 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000319023 | ENST00000527403 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
In-frame | ENST00000539574 | ENST00000393799 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000539574 | ENST00000530427 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000539574 | ENST00000393800 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000539574 | ENST00000534534 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000539574 | ENST00000524845 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000539574 | ENST00000265637 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000539574 | ENST00000524904 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000539574 | ENST00000393801 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000539574 | ENST00000265636 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000539574 | ENST00000529710 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
5CDS-intron | ENST00000539574 | ENST00000527403 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-3CDS | ENST00000530055 | ENST00000393799 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000530055 | ENST00000530427 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000530055 | ENST00000393800 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000530055 | ENST00000534534 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000530055 | ENST00000524845 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000530055 | ENST00000265637 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000530055 | ENST00000524904 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000530055 | ENST00000393801 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000530055 | ENST00000265636 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000530055 | ENST00000529710 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000530055 | ENST00000527403 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-3CDS | ENST00000526039 | ENST00000393799 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000526039 | ENST00000530427 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000526039 | ENST00000393800 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000526039 | ENST00000534534 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000526039 | ENST00000524845 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000526039 | ENST00000265637 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000526039 | ENST00000524904 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000526039 | ENST00000393801 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000526039 | ENST00000265636 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000526039 | ENST00000529710 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
intron-intron | ENST00000526039 | ENST00000527403 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000319023 | NADSYN1 | chr11 | 71189515 | + | ENST00000393799 | PPP6R3 | chr11 | 68321613 | + | 5295 | 1061 | 188 | 3082 | 964 |
ENST00000539574 | NADSYN1 | chr11 | 71189515 | + | ENST00000393799 | PPP6R3 | chr11 | 68321613 | + | 5109 | 875 | 782 | 2896 | 704 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000319023 | ENST00000393799 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + | 0.00033714 | 0.9996629 |
ENST00000539574 | ENST00000393799 | NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321613 | + | 0.000865196 | 0.99913484 |
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Fusion Genomic Features for NADSYN1-PPP6R3 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321612 | + | 2.63E-06 | 0.9999974 |
NADSYN1 | chr11 | 71189515 | + | PPP6R3 | chr11 | 68321612 | + | 2.63E-06 | 0.9999974 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NADSYN1-PPP6R3 |
Go to FGviewer for the breakpoints of chr11:71189515-chr11:68321613 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NADSYN1 | chr11:71189515 | chr11:68321613 | ENST00000319023 | + | 10 | 21 | 5_275 | 291.0 | 707.0 | Domain | CN hydrolase |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NADSYN1 | chr11:71189515 | chr11:68321613 | ENST00000319023 | + | 10 | 21 | 355_362 | 291.0 | 707.0 | Nucleotide binding | ATP |
Hgene | NADSYN1 | chr11:71189515 | chr11:68321613 | ENST00000319023 | + | 10 | 21 | 325_706 | 291.0 | 707.0 | Region | Ligase |
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Fusion Gene Sequence for NADSYN1-PPP6R3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000319023_ENST00000393799_TCGA-D9-A3Z3-06A_NADSYN1_chr11_71189515_+_PPP6R3_chr11_68321613_length(transcript)=5295nt_BP=1061nt AGACGGGGCGGGGCGATCCGTAGGCAGGGCCTGACGCCGCAGTCCTCCTTGGCCGGAGCCTCAACGGATGGGCGGGGAGGGGGCGGGGCC GGGCAACCCGGAAGGTCCGGCGTCCCAGCCGCCTACCTCGCTGGGACCCTGGTCTTGCTGTCCCCCGCTGGCCTCCTGCCCAAGCGACTG CGGCCAGGATGGGCCGGAAGGTGACCGTGGCCACCTGCGCACTCAACCAGTGGGCCCTGGACTTCGAGGGCAATTTGCAAAGAATTTTAA AGAGTATTGAAATTGCCAAAAACAGAGGAGCAAGATACAGGCTTGGACCAGAGCTGGAAATATGCGGCTACGGATGTTGGGATCATTATT ACGAGTCGGACACCCTCTTGCACTCGTTTCAAGTCCTAGCGGCCCTTGTGGAGTCTCCCGTCACTCAGGACATCATCTGCGACGTGGGGA TGCCTGTAATGCACCGAAACGTCCGCTACAACTGCAGAGTGATATTCCTCAACAGGAAGATCCTGCTCATCAGACCCAAGATGGCCTTGG CCAATGAAGGCAACTACCGCGAGCTGCGCTGGTTCACCCCGTGGTCGAGGAGTCGGCACACAGAGGAGTACTTTCTGCCTCGGATGATAC AGGACCTGACAAAGCAGGAAACCGTACCCTTCGGAGATGCGGTGCTGGTGACATGGGACACCTGCATTGGAAGTGAGATCTGTGAGGAGC TCTGGACACCCCACAGCCCGCACATCGACATGGGCCTGGATGGCGTGGAGATCATCACCAACGCCTCGGGCAGCCACCAAGTGCTGCGCA AAGCCAACACCAGGGTGGATCTCGTGACTATGGTCACCAGCAAGAACGGTGGGATTTACTTGCTGGCCAACCAGAAGGGTTGTGACGGGG ACCGCCTGTACTACGACGGCTGTGCCATGATTGCCATGAACGGAAGCGTCTTTGCTCAAGGATCCCAGTTTTCTCTGGATGACGTGGAAG TCCTGACGGCCACGCTGGATCTGGAGGACGTCCGGAGCTACAGGGCGGAGATTTCATCTCGAAACCTGGCGCGACATTCAAATGCATCAC AATCACTTTGTGAAATTGTTCGCCTGAGCAGAGACCAGATGTTACAAATTCAGAACAGTACAGAGCCCGACCCCCTGCTTGCCACTCTAG AAAAGCAAGAAATTATAGAGCAGCTTCTATCAAATATTTTCCACAAGGAGAAAAATGAGTCAGCCATAGTCAGTGCAATCCAGATATTGC TGACTTTACTTGAGACACGACGACCAACATTTGAAGGCCATATAGAGATCTGCCCACCAGGCATGAGCCATTCAGCTTGTTCAGTAAACA AGAGTGTTCTAGAAGCCATCAGAGGAAGACTTGGATCTTTTCATGAACTCCTGCTGGAGCCACCCAAGAAAAGTGTGATGAAGACCACAT GGGGTGTGCTGGATCCTCCTGTGGGGAATACCCGGTTGAATGTCATTAGGTTGATATCCAGCCTGCTTCAAACCAATACCAGCAGTATAA ATGGGGACCTTATGGAGCTGAATAGCATTGGAGTCATATTGAACATGTTCTTCAAGTATACATGGAATAACTTTTTGCATACACAAGTGG AAATTTGTATTGCACTGATTCTTGCAAGTCCTTTTGAAAACACAGAAAATGCCACAATTACCGATCAAGACTCCACTGGTGATAATTTGT TATTAAAACATCTTTTCCAAAAATGTCAATTAATAGAACGAATACTTGAAGCCTGGGAAATGAATGAGAAGAAACAGGCTGAGGGAGGAA GACGGCATGGTTACATGGGACACCTAACGAGGATAGCTAACTGTATCGTGCACAGCACTGACAAGGGCCCCAACAGTGCATTAGTGCAGC AGCTTATCAAAGATCTTCCCGACGAAGTCAGGGAACGATGGGAGACGTTCTGCACAAGCTCCTTAGGAGAAACTAACAAGAGGAACACGG TAGATCTAGTTACAACCTGCCATATTCATTCATCCAGTGATGATGAAATTGACTTTAAAGAAACGGGTTTCTCACAGGATTCTTCTTTGC AGCAAGCCTTTTCTGATTATCAGATGCAACAAATGACGTCCAATTTTATTGACCAGTTTGGCTTCAACGATGAGAAGTTTGCAGATCAAG ATGACATTGGCAATGTTTCTTTTGATCGAGTATCAGACATCAACTTTACTCTCAATACAAATGAAAGTGGAAATATTGCCTTGTTTGAAG CATGTTGTAAGGAAAGAATACAACAGTTTGATGATGGTGGCTCTGATGAGGAAGATATATGGGAGGAAAAGCACATCGCATTCACACCAG AATCCCAAAGACGATCCAGCTCGGGGAGTACAGACAGTGAGGAAAGTACAGACTCTGAAGAAGAAGATGGAGCAAAGCAAGACTTGTTTG AACCCAGCAGTGCCAACACGGAGGATAAAATGGAGGTGGACCTGAGTGAACCACCCAACTGGTCAGCTAACTTTGATGTCCCAATGGAAA CAACCCACGGTGCTCCATTGGATTCTGTGGGATCTGATGTCTGGAGCACAGAGGAGCCGATGCCAACTAAAGAGACGGGCTGGGCTTCTT TTTCAGAGTTCACGTCTTCCCTGAGCACAAAAGATTCTTTAAGGAGTAATTCTCCAGTGGAAATGGAAACCAGCACTGAACCCATGGACC CTCTGACTCCCAGTGCGGCTGCCCTGGCAGTGCAGCCAGAAGCGGCAGGCAGTGTGGCCATGGAAGCCAGCTCTGACGGAGAGGAGGATG CAGAAAGTACAGACAAGGTAACTGAGACAGTGATGAATGGCGGCATGAAGGAAACGCTCAGCCTCACTGTAGATGCCAAGACAGAGACTG CGGTCTTCAAAAGGTTATTGGGAGGATGCAGTGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGTGTC CCGAGACTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCAGCAGTCCCGAGCAGAGGACTGGCCAACCAAGCGCACCAGGTGACA CTTCAGTGAATGGCCCTGTATGACGGGTGACGTCTGCTGCTGCTGACTGAGGACTGCAGACCGCCACCACTCAGGGGCTCTGGAGGGGTC AGCTGGAGCCCACCAAGCTGTCACTGCTGCACTCACTCTGCAAGGGATCAGGACCAGCAACCTTTATATTCTAGATTCTAAGACATTGTA CAGAGAAATTCAGAAGTGTAAAAATATTGCACATTGACAAATACCAAGAATTTTTGCGTATGTTTATATTGTATTGTTCTAAATAATGGG TAGCCTGTGAAATAAGATCTTGCCACCCATGTAATAATAGTAGTAATACTATAGTTAAAATGGCTGTAAGAATAGTTTTATAAAAGTGAA TACACAGATCTATTGTATTTGAAACATAACTTTGACAATTATTAGTGTGACCAAAGTATTAGGCGGTTTTCATACATTTTTCACCTTGTA CAAAATTATGAATTCATTTTTCCTCCAGGCCGACAAGGAGTTGTAGAATGAAAATGCCCTCTAAGTGTTATTTTGGTTGTTCTAACTTAC AAAAGTGATTTTGAATAAGAAATATTTGGTGTTCTTTTTATAACCAGTTTTTGATTGGTAATTGTTTTCTGTATTGTTTAAAACGGATCA AAAATGTAAGTCTATTGGTAGAGATTAAGTAAAGTATTTATTGCTACATCATAGTTGATAAATTGATGTTATCGTAAAGCCATATGTTCT GTTCAAGTCTTGTTTGCTTGAAATGATTATTCCTACAAGTGAAACACTAGACTATTTGGAGTGTATATGGCTTGTGTTTTGGGATTTTTT TTTTTTTTTTTTGGCTTTTGTTTTTGTTTGTTTTTTTGTTTCATTTGGTAGTTCATCTGCCTTTTAACCCATTCACCAAAATTTACCTTG TTAACAAGCATCACCAATGAACATTTCAGAGCAATCTGCATATTTAACAGACCTAAAATAAATCCTATTAGGCAAGTCAGTTGAAAATGC TCGTGCTGCTAATGGAATTAGAGTGCGTTCATTTTACAGGCTAGTATTTTAAAAGTAGAAATCAAAATCTGGCACCGAAGCATGCTAATT GTTTACTGTACCTTGTGAGGTTTTCACTCATAAATTTAAACCAGTGTATTTTTTTAGAACTGGTTTGTGTATATATATAGTGATTATGGA TACTAATTCAATGTAATTTATAATTTTCTATGTCAATACAAAAATACATCACAGCCTTCTCAAACAGCTCAAGCAATATATTGTATATTG CCATATCGTCTGGTGAAAGGGTTAAATTACTTCACCTCTTGCACTTTTAGATGCAAATCAGTTTTTCATTTCTGTAATAGAAAATTATTC ACGTATTTTTACATCATTTGTTTTTCCTGACCAGTATTTAAAACCAAAAGGATATTCTGAAAAATGGCCAACAATTTTTTTAGAAGTAGC ATCCCAAGCAGCGTGCCTAAACATTACATTGCATATGGAAATAAAAGAATCAAACGTCTAATGCCTTATTATTTCTGATTTCCTTTTTCA TTTTAAGTGGTGTGGAGATTCCAGCACTCCCAGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGGCAAGGGTGGGTCCCTTGACCT TTGCACGCCTCCTCAGGAACCCCCTTTCCCGGGTGAGCCCCTCTCTGAAGAGACTGTCCTTGGGCCTCCTCTGGAAGCAGCACCCCCAGA GGACAGGGCTCCTCCTGCTTGCCTCAGGGCTGCCTGACTTGAATGGCGTTGGACCTCGGGGATTACTGGTAGATAATATGCTCTGGTCTC GCCTGGTGGTGAGTTTTGCCAGCCATGGCCAGGGTTTGGCTCCACTGGTGGCACACGTGGCCTCCGTGGTATGGACCTGGTGGCTTCTCC ATCCCACTGTGGCCTCTGTGGTATGGACCTGGTGGCTTCTCCATCCTACCCAAGGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGG AGAGAGCCTCTGGGACTTTTCTTTGGGGCATCATTTTGTTTTGTCTTTCGTAGCAGGGAAAGGATATGACAATGGGGAGGACAGTTCTTT TGGAGGTTGGAGGGGCCAAGCCAAGGACAGGAGCAAGTGTGCCCTCATTTTGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAAT >In-frame_ENST00000319023_ENST00000393799_TCGA-D9-A3Z3-06A_NADSYN1_chr11_71189515_+_PPP6R3_chr11_68321613_length(amino acids)=964AA_start in transcript=188_stop in transcript=3082 MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPV MHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLT ATLDLEDVRSYRAEISSRNLARHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQILLTL LETRRPTFEGHIEICPPGMSHSACSVNKSVLEAIRGRLGSFHELLLEPPKKSVMKTTWGVLDPPVGNTRLNVIRLISSLLQTNTSSINGD LMELNSIGVILNMFFKYTWNNFLHTQVEICIALILASPFENTENATITDQDSTGDNLLLKHLFQKCQLIERILEAWEMNEKKQAEGGRRH GYMGHLTRIANCIVHSTDKGPNSALVQQLIKDLPDEVRERWETFCTSSLGETNKRNTVDLVTTCHIHSSSDDEIDFKETGFSQDSSLQQA FSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALFEACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQ RRSSSGSTDSEESTDSEEEDGAKQDLFEPSSANTEDKMEVDLSEPPNWSANFDVPMETTHGAPLDSVGSDVWSTEEPMPTKETGWASFSE FTSSLSTKDSLRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAMEASSDGEEDAESTDKVTETVMNGGMKETLSLTVDAKTETAVF -------------------------------------------------------------- >In-frame_ENST00000539574_ENST00000393799_TCGA-D9-A3Z3-06A_NADSYN1_chr11_71189515_+_PPP6R3_chr11_68321613_length(transcript)=5109nt_BP=875nt ATCATTAACCGCGACAGAGCTGGAAGGGCTTTGAAGAGAAGGATTAAGTTCCTGCTGATGGGAAGTGTGGTCCTCTCCCCGTTCACGTCA GAGCCACAGGCACATTGGTGGTCGTGTTGATTGGCAGGTGTGTTGGCAATCAATCACCTGCCCCAGGACCCCCGCAGGTTCCCGGCCCCA CATCAAGCCACCAAATCGGAGTCCTCGGGGGTCTGTATATTTAGTGAGCACCAGGCAGTTGTTTCGTGCATTAGAATCCGGGAGCCGTTG CCTTACACGTCTCTAGAGTTCCTGATGTTGCCTGAGAGCTCCGTCGTAGGCTGTGGCCACAGGCCTGCTGTATTCAGAGTGGCCGCGCTG TCCTCAGGCTCGGGCCACTGCCCTCCACCAGGTCCTCCGTGGTGCACCTGAAATGGTCAACAGAAGTCTTGTGACACGTGGAATCATTTC AGAGTCACCCCTTCTGCCTCCTGCTCAAGCAACAGACCTGCCGATCACCCCCGTCGGGCCCGCGTTTCTCAGGGTCTTCCTAATCCCCTG GGCTTTCCGGCTTGTCGTGTGCCTGGAGTCAGGCCGCCGTGCGGCAGGCTGTTAACCTAGCCTCGGGGAGAGTGGGATGGAGCCACCTTC TCATGGAACGATCCTCGCCTTCCCTCATCTCCATTGTTTTATGGCTTCACACGGACCGTGGCTTTCTGCATGGAAGCTTGGTGGCCAGGG TGCTGTCACTTTGGGAAGCAGCCAGAGAACCACAGGATGCGTGAATCGGTCTCCTTGTCTTCATGGGCATCTCCGGCCAGGAAGTCCTGA CGGCCACGCTGGATCTGGAGGACGTCCGGAGCTACAGGGCGGAGATTTCATCTCGAAACCTGGCGCGACATTCAAATGCATCACAATCAC TTTGTGAAATTGTTCGCCTGAGCAGAGACCAGATGTTACAAATTCAGAACAGTACAGAGCCCGACCCCCTGCTTGCCACTCTAGAAAAGC AAGAAATTATAGAGCAGCTTCTATCAAATATTTTCCACAAGGAGAAAAATGAGTCAGCCATAGTCAGTGCAATCCAGATATTGCTGACTT TACTTGAGACACGACGACCAACATTTGAAGGCCATATAGAGATCTGCCCACCAGGCATGAGCCATTCAGCTTGTTCAGTAAACAAGAGTG TTCTAGAAGCCATCAGAGGAAGACTTGGATCTTTTCATGAACTCCTGCTGGAGCCACCCAAGAAAAGTGTGATGAAGACCACATGGGGTG TGCTGGATCCTCCTGTGGGGAATACCCGGTTGAATGTCATTAGGTTGATATCCAGCCTGCTTCAAACCAATACCAGCAGTATAAATGGGG ACCTTATGGAGCTGAATAGCATTGGAGTCATATTGAACATGTTCTTCAAGTATACATGGAATAACTTTTTGCATACACAAGTGGAAATTT GTATTGCACTGATTCTTGCAAGTCCTTTTGAAAACACAGAAAATGCCACAATTACCGATCAAGACTCCACTGGTGATAATTTGTTATTAA AACATCTTTTCCAAAAATGTCAATTAATAGAACGAATACTTGAAGCCTGGGAAATGAATGAGAAGAAACAGGCTGAGGGAGGAAGACGGC ATGGTTACATGGGACACCTAACGAGGATAGCTAACTGTATCGTGCACAGCACTGACAAGGGCCCCAACAGTGCATTAGTGCAGCAGCTTA TCAAAGATCTTCCCGACGAAGTCAGGGAACGATGGGAGACGTTCTGCACAAGCTCCTTAGGAGAAACTAACAAGAGGAACACGGTAGATC TAGTTACAACCTGCCATATTCATTCATCCAGTGATGATGAAATTGACTTTAAAGAAACGGGTTTCTCACAGGATTCTTCTTTGCAGCAAG CCTTTTCTGATTATCAGATGCAACAAATGACGTCCAATTTTATTGACCAGTTTGGCTTCAACGATGAGAAGTTTGCAGATCAAGATGACA TTGGCAATGTTTCTTTTGATCGAGTATCAGACATCAACTTTACTCTCAATACAAATGAAAGTGGAAATATTGCCTTGTTTGAAGCATGTT GTAAGGAAAGAATACAACAGTTTGATGATGGTGGCTCTGATGAGGAAGATATATGGGAGGAAAAGCACATCGCATTCACACCAGAATCCC AAAGACGATCCAGCTCGGGGAGTACAGACAGTGAGGAAAGTACAGACTCTGAAGAAGAAGATGGAGCAAAGCAAGACTTGTTTGAACCCA GCAGTGCCAACACGGAGGATAAAATGGAGGTGGACCTGAGTGAACCACCCAACTGGTCAGCTAACTTTGATGTCCCAATGGAAACAACCC ACGGTGCTCCATTGGATTCTGTGGGATCTGATGTCTGGAGCACAGAGGAGCCGATGCCAACTAAAGAGACGGGCTGGGCTTCTTTTTCAG AGTTCACGTCTTCCCTGAGCACAAAAGATTCTTTAAGGAGTAATTCTCCAGTGGAAATGGAAACCAGCACTGAACCCATGGACCCTCTGA CTCCCAGTGCGGCTGCCCTGGCAGTGCAGCCAGAAGCGGCAGGCAGTGTGGCCATGGAAGCCAGCTCTGACGGAGAGGAGGATGCAGAAA GTACAGACAAGGTAACTGAGACAGTGATGAATGGCGGCATGAAGGAAACGCTCAGCCTCACTGTAGATGCCAAGACAGAGACTGCGGTCT TCAAAAGGTTATTGGGAGGATGCAGTGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGTGTCCCGAGA CTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCAGCAGTCCCGAGCAGAGGACTGGCCAACCAAGCGCACCAGGTGACACTTCAG TGAATGGCCCTGTATGACGGGTGACGTCTGCTGCTGCTGACTGAGGACTGCAGACCGCCACCACTCAGGGGCTCTGGAGGGGTCAGCTGG AGCCCACCAAGCTGTCACTGCTGCACTCACTCTGCAAGGGATCAGGACCAGCAACCTTTATATTCTAGATTCTAAGACATTGTACAGAGA AATTCAGAAGTGTAAAAATATTGCACATTGACAAATACCAAGAATTTTTGCGTATGTTTATATTGTATTGTTCTAAATAATGGGTAGCCT GTGAAATAAGATCTTGCCACCCATGTAATAATAGTAGTAATACTATAGTTAAAATGGCTGTAAGAATAGTTTTATAAAAGTGAATACACA GATCTATTGTATTTGAAACATAACTTTGACAATTATTAGTGTGACCAAAGTATTAGGCGGTTTTCATACATTTTTCACCTTGTACAAAAT TATGAATTCATTTTTCCTCCAGGCCGACAAGGAGTTGTAGAATGAAAATGCCCTCTAAGTGTTATTTTGGTTGTTCTAACTTACAAAAGT GATTTTGAATAAGAAATATTTGGTGTTCTTTTTATAACCAGTTTTTGATTGGTAATTGTTTTCTGTATTGTTTAAAACGGATCAAAAATG TAAGTCTATTGGTAGAGATTAAGTAAAGTATTTATTGCTACATCATAGTTGATAAATTGATGTTATCGTAAAGCCATATGTTCTGTTCAA GTCTTGTTTGCTTGAAATGATTATTCCTACAAGTGAAACACTAGACTATTTGGAGTGTATATGGCTTGTGTTTTGGGATTTTTTTTTTTT TTTTTTGGCTTTTGTTTTTGTTTGTTTTTTTGTTTCATTTGGTAGTTCATCTGCCTTTTAACCCATTCACCAAAATTTACCTTGTTAACA AGCATCACCAATGAACATTTCAGAGCAATCTGCATATTTAACAGACCTAAAATAAATCCTATTAGGCAAGTCAGTTGAAAATGCTCGTGC TGCTAATGGAATTAGAGTGCGTTCATTTTACAGGCTAGTATTTTAAAAGTAGAAATCAAAATCTGGCACCGAAGCATGCTAATTGTTTAC TGTACCTTGTGAGGTTTTCACTCATAAATTTAAACCAGTGTATTTTTTTAGAACTGGTTTGTGTATATATATAGTGATTATGGATACTAA TTCAATGTAATTTATAATTTTCTATGTCAATACAAAAATACATCACAGCCTTCTCAAACAGCTCAAGCAATATATTGTATATTGCCATAT CGTCTGGTGAAAGGGTTAAATTACTTCACCTCTTGCACTTTTAGATGCAAATCAGTTTTTCATTTCTGTAATAGAAAATTATTCACGTAT TTTTACATCATTTGTTTTTCCTGACCAGTATTTAAAACCAAAAGGATATTCTGAAAAATGGCCAACAATTTTTTTAGAAGTAGCATCCCA AGCAGCGTGCCTAAACATTACATTGCATATGGAAATAAAAGAATCAAACGTCTAATGCCTTATTATTTCTGATTTCCTTTTTCATTTTAA GTGGTGTGGAGATTCCAGCACTCCCAGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGGCAAGGGTGGGTCCCTTGACCTTTGCAC GCCTCCTCAGGAACCCCCTTTCCCGGGTGAGCCCCTCTCTGAAGAGACTGTCCTTGGGCCTCCTCTGGAAGCAGCACCCCCAGAGGACAG GGCTCCTCCTGCTTGCCTCAGGGCTGCCTGACTTGAATGGCGTTGGACCTCGGGGATTACTGGTAGATAATATGCTCTGGTCTCGCCTGG TGGTGAGTTTTGCCAGCCATGGCCAGGGTTTGGCTCCACTGGTGGCACACGTGGCCTCCGTGGTATGGACCTGGTGGCTTCTCCATCCCA CTGTGGCCTCTGTGGTATGGACCTGGTGGCTTCTCCATCCTACCCAAGGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGGAGAGAG CCTCTGGGACTTTTCTTTGGGGCATCATTTTGTTTTGTCTTTCGTAGCAGGGAAAGGATATGACAATGGGGAGGACAGTTCTTTTGGAGG TTGGAGGGGCCAAGCCAAGGACAGGAGCAAGTGTGCCCTCATTTTGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAATTATGAG >In-frame_ENST00000539574_ENST00000393799_TCGA-D9-A3Z3-06A_NADSYN1_chr11_71189515_+_PPP6R3_chr11_68321613_length(amino acids)=704AA_start in transcript=782_stop in transcript=2896 MGISGQEVLTATLDLEDVRSYRAEISSRNLARHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAI VSAIQILLTLLETRRPTFEGHIEICPPGMSHSACSVNKSVLEAIRGRLGSFHELLLEPPKKSVMKTTWGVLDPPVGNTRLNVIRLISSLL QTNTSSINGDLMELNSIGVILNMFFKYTWNNFLHTQVEICIALILASPFENTENATITDQDSTGDNLLLKHLFQKCQLIERILEAWEMNE KKQAEGGRRHGYMGHLTRIANCIVHSTDKGPNSALVQQLIKDLPDEVRERWETFCTSSLGETNKRNTVDLVTTCHIHSSSDDEIDFKETG FSQDSSLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALFEACCKERIQQFDDGGSDEEDIWEE KHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFEPSSANTEDKMEVDLSEPPNWSANFDVPMETTHGAPLDSVGSDVWSTEEPMPT KETGWASFSEFTSSLSTKDSLRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAMEASSDGEEDAESTDKVTETVMNGGMKETLSLT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NADSYN1-PPP6R3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NADSYN1-PPP6R3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NADSYN1-PPP6R3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NADSYN1 | C0000772 | Multiple congenital anomalies | 1 | GENOMICS_ENGLAND |
Hgene | NADSYN1 | C0426706 | Absent kidney | 1 | GENOMICS_ENGLAND |