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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NANS-WNK2 (FusionGDB2 ID:56829) |
Fusion Gene Summary for NANS-WNK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NANS-WNK2 | Fusion gene ID: 56829 | Hgene | Tgene | Gene symbol | NANS | WNK2 | Gene ID | 54187 | 65268 |
| Gene name | N-acetylneuraminate synthase | WNK lysine deficient protein kinase 2 | |
| Synonyms | HEL-S-100|SAS|SEMDCG|SEMDG | NY-CO-43|P/OKcl.13|PRKWNK2|SDCCAG43 | |
| Cytomap | 9q22.33 | 9q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sialic acid synthaseN-acetylneuraminate-9-phosphate synthaseN-acetylneuraminic acid phosphate synthaseN-acetylneuraminic acid synthaseepididymis secretory protein Li 100sialic acid phosphate synthase | serine/threonine-protein kinase WNK2antigen NY-CO-43mitogen-activated protein kinase kinase kinaseprotein kinase lysine-deficient 2protein kinase with no lysine 2serologically defined colon cancer antigen 43 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9NR45 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000210444, ENST00000461452, | ENST00000427277, ENST00000297954, ENST00000395475, ENST00000356055, ENST00000349097, ENST00000395477, ENST00000471076, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 10 X 9 X 7=630 |
| # samples | 2 | 12 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NANS [Title/Abstract] AND WNK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | NANS(100823279)-WNK2(96019230), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | WNK2 | GO:0006468 | protein phosphorylation | 21733846 |
| Tgene | WNK2 | GO:0046777 | protein autophosphorylation | 17667937 |
| Fusion gene breakpoints across NANS (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across WNK2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-ZG-A9LN-01A | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
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Fusion Gene ORF analysis for NANS-WNK2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000210444 | ENST00000427277 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| In-frame | ENST00000210444 | ENST00000297954 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| In-frame | ENST00000210444 | ENST00000395475 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| 5CDS-5UTR | ENST00000210444 | ENST00000356055 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| 5CDS-5UTR | ENST00000210444 | ENST00000349097 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| 5CDS-5UTR | ENST00000210444 | ENST00000395477 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| 5CDS-intron | ENST00000210444 | ENST00000471076 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-3CDS | ENST00000461452 | ENST00000427277 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-3CDS | ENST00000461452 | ENST00000297954 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-3CDS | ENST00000461452 | ENST00000395475 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-5UTR | ENST00000461452 | ENST00000356055 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-5UTR | ENST00000461452 | ENST00000349097 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-5UTR | ENST00000461452 | ENST00000395477 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| intron-intron | ENST00000461452 | ENST00000471076 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000210444 | NANS | chr9 | 100823279 | + | ENST00000427277 | WNK2 | chr9 | 96019230 | + | 4903 | 418 | 70 | 4902 | 1611 |
| ENST00000210444 | NANS | chr9 | 100823279 | + | ENST00000297954 | WNK2 | chr9 | 96019230 | + | 5366 | 418 | 70 | 5121 | 1683 |
| ENST00000210444 | NANS | chr9 | 100823279 | + | ENST00000395475 | WNK2 | chr9 | 96019230 | + | 5062 | 418 | 70 | 4881 | 1603 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000210444 | ENST00000427277 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + | 0.01061413 | 0.98938584 |
| ENST00000210444 | ENST00000297954 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + | 0.013454085 | 0.9865459 |
| ENST00000210444 | ENST00000395475 | NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019230 | + | 0.010516575 | 0.9894834 |
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Fusion Genomic Features for NANS-WNK2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019229 | + | 8.23E-08 | 0.9999999 |
| NANS | chr9 | 100823279 | + | WNK2 | chr9 | 96019229 | + | 8.23E-08 | 0.9999999 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NANS-WNK2 |
| Go to FGviewer for the breakpoints of chr9:100823279-chr9:96019230 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NANS | . |
| FUNCTION: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NANS | chr9:100823279 | chr9:96019230 | ENST00000210444 | + | 2 | 6 | 294_353 | 116.0 | 360.0 | Domain | AFP-like |
| Tgene | WNK2 | chr9:100823279 | chr9:96019230 | ENST00000297954 | 8 | 30 | 195_453 | 730.0 | 2298.0 | Domain | Protein kinase | |
| Tgene | WNK2 | chr9:100823279 | chr9:96019230 | ENST00000297954 | 8 | 30 | 275_278 | 730.0 | 2298.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for NANS-WNK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000210444_ENST00000427277_TCGA-ZG-A9LN-01A_NANS_chr9_100823279_+_WNK2_chr9_96019230_length(transcript)=4903nt_BP=418nt AGAGTAGAGGCGGCGGCGGCGGCGGCCGGACCCAGACTGGTAGTGAGGCTTTGGACCCCGAGCCGCTGCAATGCCGCTGGAGCTGGAGCT GTGTCCCGGGCGCTGGGTGGGCGGGCAACACCCGTGCTTCATCATTGCCGAGATCGGCCAGAACCACCAGGGCGACCTGGACGTAGCCAA GCGCATGATCCGCATGGCCAAGGAGTGTGGGGCTGATTGTGCTAAGTTCCAGAAGAGTGAGCTAGAATTCAAGTTTAATCGGAAAGCCTT GGAGAGGCCATACACCTCGAAGCATTCCTGGGGGAAGACGTACGGGGAGCACAAACGACATCTGGAGTTCAGCCATGACCAGTACAGGGA GCTGCAGAGGTACGCCGAGGAGGTTGGGATCTTCTTCACTGCCTCTGGCATGGATGAGCCTCCTCCGCTGGCCCAGCCGACACCCCTGCC GCAGGTCCTGGCCCCACAGCCCGTGGTCCCCCTCCAGCCGGTTCCCCCCCACCTGCCACCGTACCTGGCTCCAGCCTCCCAGGTGGGGGC CCCCGCTCAGCTGAAGCCCCTCCAGATGCCACAGGCGCCCCTGCAGCCGCTTGCTCAAGTCCCTCCGCAGATGCCCCCGATTCCTGTTGT GCCCCCCATCACGCCCCTGGCGGGAATCGACGGCCTCCCTCCGGCCCTCCCAGACCTGCCGACCGCGACTGTGCCTCCCGTGCCACCACC TCAGTATTTCTCTCCAGCCGTGATCTTGCCGAGCCTCGCTGCCCCACTCCCCCCTGCGTCCCCAGCCTTGCCTCTGCAGGCTGTGAAGCT GCCCCACCCCCCTGGGGCGCCCCTGGCCATGCCCTGCCGGACCATTGTGCCAAATGCACCGGCCACTATCCCCCTGCTGGCCGTAGCCCC ACCGGGCGTGGCTGCCCTGTCCATTCATTCTGCCGTGGCCCAGCTCCCAGGCCAACCTGTGTACCCAGCGGCCTTCCCACAGATGGCGCC TACTGACGTCCCTCCTTCCCCCCATCACACGGTGCAGAATATGAGGGCCACCCCTCCACAGCCGGCACTGCCTCCACAACCCACACTGCC CCCACAACCCGTGCTGCCCCCGCAACCCACGCTGCCCCCTCAACCTGTGTTGCCCCCGCAACCCACACGGCCCCCTCAACCTGTGCTGCC CCCGCAACCCATGCTGCCCCCACAACCTGTGCTGCCCCCGCAGCCGGCACTGCCTGTGCGCCCTGAGCCCCTCCAGCCCCACCTTCCTGA ACAAGCTGCTCCAGCTGCTACACCAGGGAGCCAGATTCTGCTTGGCCACCCAGCTCCCTATGCTGTGGACGTCGCCGCTCAGGTCCCCAC CGTGCCTGTGCCACCGGCTGCGGTCCTCTCGCCGCCTCTGCCGGAAGTGCTGCTGCCTGCCGCCCCTGAGCTCCTGCCTCAGTTCCCCAG CTCCCTGGCCACGGTGTCTGCCTCTGTGCAGAGTGTGCCCACCCAGACTGCCACACTTCTGCCACCAGCAAACCCACCGCTGCCTGGCGG GCCCGGGATCGCCAGCCCTTGCCCAACTGTCCAGCTGACGGTGGAACCAGTCCAAGAGGAGCAGGCCTCACAGGACAAGCCGCCCGGCCT CCCGCAGAGCTGTGAGAGCTATGGAGGTTCTGATGTCACTTCTGGAAAAGAGCTGAGTGACAGCTGTGAAGGCGCCTTTGGAGGGGGCAG GCTGGAGGGCAGGGCAGCCCGAAAACACCACCGCAGGTCCACGCGTGCGCGCTCCCGGCAGGAGAGGGCCAGCCGGCCCCGGCTTACCAT CTTGAACGTGTGCAACACTGGGGACAAGATGGTGGAGTGCCAGCTGGAGACGCACAACCACAAGATGGTGACCTTCAAGTTCGACTTGGA CGGGGACGCACCCGATGAAATTGCCACGTATATGGTGGAGCATGACTTTATCCTGCAGGCCGAGCGGGAAACGTTCATCGAGCAGATGAA GGATGTCATGGACAAGGCAGAGGACATGCTCAGCGAGGACACAGACGCCGACCGTGGCTCCGACCCAGGGACCAGCCCGCCACACCTCAG CACCTGCGGCCTGGGCACCGGGGAGGAGAGCCGACAATCCCAAGCCAACGCCCCCGTGTATCAGCAGAACGTCCTGCACACCGGGAAGAG GTGGTTCATCATCTGTCCGGTGGCTGAGCACCCCGCCCCCGAGGCCCCTGAATCTTCGCCCCCACTTCCTCTAAGCTCCCTGCCGCCAGA AGCCAGCCAAGATTCAGCGCCCTATAAAGACCAGCTGTCCTCGAAGGAACAACCCAGCTTTCTAGCCAGTCAGCAGCTCCTGAGCCAGGC GGGCCCCAGCAACCCTCCTGGGGCACCCCCAGCCCCTTTGGCCCCCTCCTCCCCTCCTGTGACTGCTCTGCCCCAAGATGGAGCAGCTCC AGCCACCAGCACCATGCCAGAGCCAGCGTCAGGAACTGCCAGCCAGGCAGGGGGTCCAGGGACACCTCAGGGGCTGACCAGTGAGCTCGA GACGTCTCAGCCACTAGCGGAGACTCACGAGGCCCCGCTTGCTGTGCAGCCCCTCGTGGTGGGCCTAGCACCTTGCACTCCAGCTCCAGA GGCTGCCTCAACCAGGGACGCCAGTGCCCCAAGGGAGCCCCTGCCACCTCCTGCACCTGAGCCCAGCCCCCACAGCGGGACCCCACAGCC CGCCTTGGGTCAACCTGCTCCCCTGCTTCCTGCCGCAGTGGGGGCCGTCAGCCTGGCCACCTCCCAGCTCCCAAGCCCACCCCTGGGGCC CACCGTCCCCCCACAGCCACCCTCGGCCCTGGAGTCGGATGGGGAAGGGCCGCCCCCCAGGGTGGGCTTTGTGGACAGCACCATCAAGAG CCTGGACGAGAAGCTGCGGACTCTGCTCTACCAGGAGCACGTGCCCACCTCCTCAGCCTCAGCTGGGACCCCTGTGGAGGTGGGCGACAG AGACTTCACCCTGGAGCCCCTGAGAGGGGACCAGCCCCGCTCAGAGGTCTGCGGGGGGGACCTGGCCCTGCCCCCAGTGCCTAAGGAGGC GGTCTCAGGGCGTGTCCAGCTGCCCCAGCCCTTGGTGGAGAAGTCAGAACTGGCCCCCACTCGAGGGGCCGTGATGGAGCAGGGCACGTC CTCGTCAATGACAGCAGAGTCGTCTCCCAGGAGTATGCTAGGCTATGACAGAGATGGAAGGCAGGTGGCCTCAGACTCCCATGTGGTCCC CAGCGTCCCCCAGGATGTACCTGCTTTTGTGAGACCTGCACGTGTGGAGCCCACAGACAGGGATGGTGGAGAAGCTGGAGAAAGCTCGGC AGAGCCCCCGCCGAGTGACATGGGCACAGTGGGGGGCCAGGCTAGCCACCCCCAGACACTCGGCGCTCGAGCTTTGGGGTCCCCTCGGAA ACGTCCAGAGCAGCAGGATGTCAGCTCACCAGCCAAGACTGTGGGCCGTTTCTCGGTGGTCAGCACTCAGGACGAGTGGACCCTGGCCTC CCCCCACAGCCTGAGATACTCTGCCCCACCCGACGTCTACCTGGACGAGGCCCCCTCCAGCCCCGACGTGAAGCTGGCAGTGCGGCGGGC GCAGACGGCCTCCTCCATCGAGGTCGGCGTGGGCGAGCCCGTGTCCAGCGACTCTGGGGACGAGGGCCCTCGGGCGAGACCCCCGGTGCA GAAGCAGGCGTCCCTGCCCGTGAGTGGCAGCGTGGCTGGCGACTTCGTGAAGAAGGCCACCGCCTTCCTGCAGAGGCCTTCTCGGGCCGG CTCGCTGGGCCCCGAGACACCCAGCAGGGTGGGCATGAAGGTCCCCACGATCAGCGTGACCTCCTTCCATTCCCAGTCGTCCTACATCAG CAGCGACAATGATTCGGAGCTCGAGGATGCTGACATAAAGAAGGAGCTGCAGAGTCTGCGGGAGAAGCACCTGAAGGAGATCTCGGAGCT GCAGAGCCAGCAGAAGCAGGAGATCGAAGCTCTGTACCGCCGCCTGGGCAAGCCACTGCCCCCCAACGTGGGCTTCTTCCACACGGCACC CCCCACTGGCCGCCGGAGAAAAACCAGCAAGAGCAAGCTGAAGGCAGGCAAGCTGCTAAATCCCCTGGTGCGGCAGCTCAAGGTCGTGGC CTCCAGCACAGGTCACTTGGCTGACTCCAGCAGAGGCCCTCCCGCTAAGGACCCTGCCCAAGCCAGTGTGGGGCTCACTGCAGACAGCAC GGGCCTGAGCGGGAAGGCAGTGCAGACCCAGCAGCCCTGCTCCGTCCGGGCCTCCCTGTCTTCGGACATCTGCTCCGGCTTAGCCAGTGA TGGAGGCGGAGCGCGTGGCCAAGGCTGGACGGTTTACCACCCAACGTCTGAGAGAGTGACCTATAAGTCTAGTAGCAAACCTCGTGCTCG ATTCCTCAGTGGACCCGTATCTGTGTCCATCTGGTCTGCCCTGAAGCGTCTCTGCCTAGGCAAAGAACACAGCAGTAGGTCCTCCACCAG CAGCCTGGCCCCAGGCCCTGAGCCAGGCCCCCAGCCCGCCCTGCACGTCCAGGCGCAGGTGAACAACAGCAACAACAAGAAGGGTACCTT CACGGACGACCTGCACAAGCTGGTGGACGAGTGGACGAGCAAGACGGTGGGGGCCGCGCAGCTGAAGCCCACGCTCAACCAGCTGAAGCA GACCCAGAAGCTGCAAGACATGGAGGCCCAGGCAGGCTGGGCTGCCCCTGGCGAGGCGCGGGCTATGACCGCACCTCGAGCAGGAGTGGG GATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGGTTC >In-frame_ENST00000210444_ENST00000427277_TCGA-ZG-A9LN-01A_NANS_chr9_100823279_+_WNK2_chr9_96019230_length(amino acids)=1611AA_start in transcript=70_stop in transcript=4902 MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEF SHDQYRELQRYAEEVGIFFTASGMDEPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQ MPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATI PLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTR PPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPE LLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSGKELSDSCE GAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERE TFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPPLP LSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQ GLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQL PSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLAL PPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGG EAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDV KLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFH SQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLV RQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTSERVTYKS SSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKP -------------------------------------------------------------- >In-frame_ENST00000210444_ENST00000297954_TCGA-ZG-A9LN-01A_NANS_chr9_100823279_+_WNK2_chr9_96019230_length(transcript)=5366nt_BP=418nt AGAGTAGAGGCGGCGGCGGCGGCGGCCGGACCCAGACTGGTAGTGAGGCTTTGGACCCCGAGCCGCTGCAATGCCGCTGGAGCTGGAGCT GTGTCCCGGGCGCTGGGTGGGCGGGCAACACCCGTGCTTCATCATTGCCGAGATCGGCCAGAACCACCAGGGCGACCTGGACGTAGCCAA GCGCATGATCCGCATGGCCAAGGAGTGTGGGGCTGATTGTGCTAAGTTCCAGAAGAGTGAGCTAGAATTCAAGTTTAATCGGAAAGCCTT GGAGAGGCCATACACCTCGAAGCATTCCTGGGGGAAGACGTACGGGGAGCACAAACGACATCTGGAGTTCAGCCATGACCAGTACAGGGA GCTGCAGAGGTACGCCGAGGAGGTTGGGATCTTCTTCACTGCCTCTGGCATGGATGAGCCTCCTCCGCTGGCCCAGCCGACACCCCTGCC GCAGGTCCTGGCCCCACAGCCCGTGGTCCCCCTCCAGCCGGTTCCCCCCCACCTGCCACCGTACCTGGCTCCAGCCTCCCAGGTGGGGGC CCCCGCTCAGCTGAAGCCCCTCCAGATGCCACAGGCGCCCCTGCAGCCGCTTGCTCAAGTCCCTCCGCAGATGCCCCCGATTCCTGTTGT GCCCCCCATCACGCCCCTGGCGGGAATCGACGGCCTCCCTCCGGCCCTCCCAGACCTGCCGACCGCGACTGTGCCTCCCGTGCCACCACC TCAGTATTTCTCTCCAGCCGTGATCTTGCCGAGCCTCGCTGCCCCACTCCCCCCTGCGTCCCCAGCCTTGCCTCTGCAGGCTGTGAAGCT GCCCCACCCCCCTGGGGCGCCCCTGGCCATGCCCTGCCGGACCATTGTGCCAAATGCACCGGCCACTATCCCCCTGCTGGCCGTAGCCCC ACCGGGCGTGGCTGCCCTGTCCATTCATTCTGCCGTGGCCCAGCTCCCAGGCCAACCTGTGTACCCAGCGGCCTTCCCACAGATGGCGCC TACTGACGTCCCTCCTTCCCCCCATCACACGGTGCAGAATATGAGGGCCACCCCTCCACAGCCGGCACTGCCTCCACAACCCACACTGCC CCCACAACCCGTGCTGCCCCCGCAACCCACGCTGCCCCCTCAACCTGTGTTGCCCCCGCAACCCACACGGCCCCCTCAACCTGTGCTGCC CCCGCAACCCATGCTGCCCCCACAACCTGTGCTGCCCCCGCAGCCGGCACTGCCTGTGCGCCCTGAGCCCCTCCAGCCCCACCTTCCTGA ACAAGCTGCTCCAGCTGCTACACCAGGGAGCCAGATTCTGCTTGGCCACCCAGCTCCCTATGCTGTGGACGTCGCCGCTCAGGTCCCCAC CGTGCCTGTGCCACCGGCTGCGGTCCTCTCGCCGCCTCTGCCGGAAGTGCTGCTGCCTGCCGCCCCTGAGCTCCTGCCTCAGTTCCCCAG CTCCCTGGCCACGGTGTCTGCCTCTGTGCAGAGTGTGCCCACCCAGACTGCCACACTTCTGCCACCAGCAAACCCACCGCTGCCTGGCGG GCCCGGGATCGCCAGCCCTTGCCCAACTGTCCAGCTGACGGTGGAACCAGTCCAAGAGGAGCAGGCCTCACAGGACAAGCCGCCCGGCCT CCCGCAGAGCTGTGAGAGCTATGGAGGTTCTGATGTCACTTCTGGAAAAGAGCTGAGTGACAGCTGTGAAGGCGCCTTTGGAGGGGGCAG GCTGGAGGGCAGGGCAGCCCGAAAACACCACCGCAGGTCCACGCGTGCGCGCTCCCGGCAGGAGAGGGCCAGCCGGCCCCGGCTTACCAT CTTGAACGTGTGCAACACTGGGGACAAGATGGTGGAGTGCCAGCTGGAGACGCACAACCACAAGATGGTGACCTTCAAGTTCGACTTGGA CGGGGACGCACCCGATGAAATTGCCACGTATATGGTGGAGCATGACTTTATCCTGCAGGCCGAGCGGGAAACGTTCATCGAGCAGATGAA GGATGTCATGGACAAGGCAGAGGACATGCTCAGCGAGGACACAGACGCCGACCGTGGCTCCGACCCAGGGACCAGCCCGCCACACCTCAG CACCTGCGGCCTGGGCACCGGGGAGGAGAGCCGACAATCCCAAGCCAACGCCCCCGTGTATCAGCAGAACGTCCTGCACACCGGGAAGAG GTGGTTCATCATCTGTCCGGTGGCTGAGCACCCCGCCCCCGAGGCCCCTGAATCTTCGCCCCCACTTCCTCTAAGCTCCCTGCCGCCAGA AGCCAGCCAAGGTCCATGCAGGGGGCTCACCCTGCCCTGTCTCCCATGGCGCAGAGCAGCCTGTGGGGCTGTGTTCCTATCCTTGTTTTC TGCTGAATCAGCTCAGTCAAAGCAGCCTCCAGATTCAGCGCCCTATAAAGACCAGCTGTCCTCGAAGGAACAACCCAGCTTTCTAGCCAG TCAGCAGCTCCTGAGCCAGGCGGGCCCCAGCAACCCTCCTGGGGCACCCCCAGCCCCTTTGGCCCCCTCCTCCCCTCCTGTGACTGCTCT GCCCCAAGATGGAGCAGCTCCAGCCACCAGCACCATGCCAGAGCCAGCGTCAGGAACTGCCAGCCAGGCAGGGGGTCCAGGGACACCTCA GGGGCTGACCAGTGAGCTCGAGACGTCTCAGCCACTAGCGGAGACTCACGAGGCCCCGCTTGCTGTGCAGCCCCTCGTGGTGGGCCTAGC ACCTTGCACTCCAGCTCCAGAGGCTGCCTCAACCAGGGACGCCAGTGCCCCAAGGGAGCCCCTGCCACCTCCTGCACCTGAGCCCAGCCC CCACAGCGGGACCCCACAGCCCGCCTTGGGTCAACCTGCTCCCCTGCTTCCTGCCGCAGTGGGGGCCGTCAGCCTGGCCACCTCCCAGCT CCCAAGCCCACCCCTGGGGCCCACCGTCCCCCCACAGCCACCCTCGGCCCTGGAGTCGGATGGGGAAGGGCCGCCCCCCAGGGTGGGCTT TGTGGACAGCACCATCAAGAGCCTGGACGAGAAGCTGCGGACTCTGCTCTACCAGGAGCACGTGCCCACCTCCTCAGCCTCAGCTGGGAC CCCTGTGGAGGTGGGCGACAGAGACTTCACCCTGGAGCCCCTGAGAGGGGACCAGCCCCGCTCAGAGGTCTGCGGGGGGGACCTGGCCCT GCCCCCAGTGCCTAAGGAGGCGGTCTCAGGGCGTGTCCAGCTGCCCCAGCCCTTGGTGGAGAAGTCAGAACTGGCCCCCACTCGAGGGGC CGTGATGGAGCAGGGCACGTCCTCGTCAATGACAGCAGAGTCGTCTCCCAGGAGTATGCTAGGCTATGACAGAGATGGAAGGCAGGTGGC CTCAGACTCCCATGTGGTCCCCAGCGTCCCCCAGGATGTACCTGCTTTTGTGAGACCTGCACGTGTGGAGCCCACAGACAGGGATGGTGG AGAAGCTGGAGAAAGCTCGGCAGAGCCCCCGCCGAGTGACATGGGCACAGTGGGGGGCCAGGCTAGCCACCCCCAGACACTCGGCGCTCG AGCTTTGGGGTCCCCTCGGAAACGTCCAGAGCAGCAGGATGTCAGCTCACCAGCCAAGACTGTGGGCCGTTTCTCGGTGGTCAGCACTCA GGACGAGTGGACCCTGGCCTCCCCCCACAGCCTGAGATACTCTGCCCCACCCGACGTCTACCTGGACGAGGCCCCCTCCAGCCCCGACGT GAAGCTGGCAGTGCGGCGGGCGCAGACGGCCTCCTCCATCGAGGTCGGCGTGGGCGAGCCCGTGTCCAGCGACTCTGGGGACGAGGGCCC TCGGGCGAGACCCCCGGTGCAGAAGCAGGCGTCCCTGCCCGTGAGTGGCAGCGTGGCTGGCGACTTCGTGAAGAAGGCCACCGCCTTCCT GCAGAGGCCTTCTCGGGCCGGCTCGCTGGGCCCCGAGACACCCAGCAGGGTGGGCATGAAGGTCCCCACGATCAGCGTGACCTCCTTCCA TTCCCAGTCGTCCTACATCAGCAGCGACAATGATTCGGAGCTCGAGGATGCTGACATAAAGAAGGAGCTGCAGAGTCTGCGGGAGAAGCA CCTGAAGGAGATCTCGGAGCTGCAGAGCCAGCAGAAGCAGGAGATCGAAGCTCTGTACCGCCGCCTGGGCAAGCCACTGCCCCCCAACGT GGGCTTCTTCCACACGGCACCCCCCACTGGCCGCCGGAGAAAAACCAGCAAGAGCAAGCTGAAGGCAGGCAAGCTGCTAAATCCCCTGGT GCGGCAGCTCAAGGTCGTGGCCTCCAGCACAGGTCACTTGGCTGACTCCAGCAGAGGCCCTCCCGCTAAGGACCCTGCCCAAGCCAGTGT GGGGCTCACTGCAGACAGCACGGGCCTGAGCGGGAAGGCAGTGCAGACCCAGCAGCCCTGCTCCGTCCGGGCCTCCCTGTCTTCGGACAT CTGCTCCGGCTTAGCCAGTGATGGAGGCGGAGCGCGTGGCCAAGGCTGGACGGTTTACCACCCAACGTCTGAGAGAGTGACCTATAAGTC TAGTAGCAAACCTCGTGCTCGATTCCTCAGTGGACCCGTATCTGTGTCCATCTGGTCTGCCCTGAAGCGTCTCTGCCTAGGCAAAGAACA CAGCAGTAGGTCCTCCACCAGCAGCCTGGCCCCAGGCCCTGAGCCAGGCCCCCAGCCCGCCCTGCACGTCCAGGCGCAGGTGAACAACAG CAACAACAAGAAGGGTACCTTCACGGACGACCTGCACAAGCTGGTGGACGAGTGGACGAGCAAGACGGTGGGGGCCGCGCAGCTGAAGCC CACGCTCAACCAGCTGAAGCAGACCCAGAAGCTGCAAGACATGGAGGCCCAGGCAGGCTGGGCTGCCCCTGGCGAGGCGCGGGCTATGAC CGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACCCT GTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGTGGTTTGGCCTCCGAGTCCCCCCCACCGCCTGCTGTGG GCACAGCACTCAGCCGCGAGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCTTTGCGGCTTCAGACCCTGTTCGCTCCTAGGTTCCTGT GGTCCACGCGCCGTCTCCACACCCACTTCCTATACTTGAGTTGATGGTTAGAACCTTGTCGTCACCCTGCAGAAGTACAGTGCCTTGAAT GCCAGCTTTTCCGTTCCCTGATGAAAAGATATGTTAAAAAAAATTATCGGAAAAGGTTTCATTTGCAATTGGCTTGTGCATTGATAATCT >In-frame_ENST00000210444_ENST00000297954_TCGA-ZG-A9LN-01A_NANS_chr9_100823279_+_WNK2_chr9_96019230_length(amino acids)=1683AA_start in transcript=70_stop in transcript=5121 MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEF SHDQYRELQRYAEEVGIFFTASGMDEPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQ MPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATI PLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTR PPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPE LLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSGKELSDSCE GAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERE TFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPPLP LSSLPPEASQGPCRGLTLPCLPWRRAACGAVFLSLFSAESAQSKQPPDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPS SPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPP PAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPT SSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGYD RDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGR FSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVSGSVAGDFV KKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLG KPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGLSGKAVQTQQPCSVR ASLSSDICSGLASDGGGARGQGWTVYHPTSERVTYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHV QAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGEARAMTAPRAGVGMPRLPPAPGPLSTTVI -------------------------------------------------------------- >In-frame_ENST00000210444_ENST00000395475_TCGA-ZG-A9LN-01A_NANS_chr9_100823279_+_WNK2_chr9_96019230_length(transcript)=5062nt_BP=418nt AGAGTAGAGGCGGCGGCGGCGGCGGCCGGACCCAGACTGGTAGTGAGGCTTTGGACCCCGAGCCGCTGCAATGCCGCTGGAGCTGGAGCT GTGTCCCGGGCGCTGGGTGGGCGGGCAACACCCGTGCTTCATCATTGCCGAGATCGGCCAGAACCACCAGGGCGACCTGGACGTAGCCAA GCGCATGATCCGCATGGCCAAGGAGTGTGGGGCTGATTGTGCTAAGTTCCAGAAGAGTGAGCTAGAATTCAAGTTTAATCGGAAAGCCTT GGAGAGGCCATACACCTCGAAGCATTCCTGGGGGAAGACGTACGGGGAGCACAAACGACATCTGGAGTTCAGCCATGACCAGTACAGGGA GCTGCAGAGGTACGCCGAGGAGGTTGGGATCTTCTTCACTGCCTCTGGCATGGATGAGCCTCCTCCGCTGGCCCAGCCGACACCCCTGCC GCAGGTCCTGGCCCCACAGCCCGTGGTCCCCCTCCAGCCGGTTCCCCCCCACCTGCCACCGTACCTGGCTCCAGCCTCCCAGGTGGGGGC CCCCGCTCAGCTGAAGCCCCTCCAGATGCCACAGGCGCCCCTGCAGCCGCTTGCTCAAGTCCCTCCGCAGATGCCCCCGATTCCTGTTGT GCCCCCCATCACGCCCCTGGCGGGAATCGACGGCCTCCCTCCGGCCCTCCCAGACCTGCCGACCGCGACTGTGCCTCCCGTGCCACCACC TCAGTATTTCTCTCCAGCCGTGATCTTGCCGAGCCTCGCTGCCCCACTCCCCCCTGCGTCCCCAGCCTTGCCTCTGCAGGCTGTGAAGCT GCCCCACCCCCCTGGGGCGCCCCTGGCCATGCCCTGCCGGACCATTGTGCCAAATGCACCGGCCACTATCCCCCTGCTGGCCGTAGCCCC ACCGGGCGTGGCTGCCCTGTCCATTCATTCTGCCGTGGCCCAGCTCCCAGGCCAACCTGTGTACCCAGCGGCCTTCCCACAGATGGCGCC TACTGACGTCCCTCCTTCCCCCCATCACACGGTGCAGAATATGAGGGCCACCCCTCCACAGCCGGCACTGCCTCCACAACCCACACTGCC CCCACAACCCGTGCTGCCCCCGCAACCCACGCTGCCCCCTCAACCTGTGTTGCCCCCGCAACCCACACGGCCCCCTCAACCTGTGCTGCC CCCGCAACCCATGCTGCCCCCACAACCTGTGCTGCCCCCGCAGCCGGCACTGCCTGTGCGCCCTGAGCCCCTCCAGCCCCACCTTCCTGA ACAAGCTGCTCCAGCTGCTACACCAGGGAGCCAGATTCTGCTTGGCCACCCAGCTCCCTATGCTGTGGACGTCGCCGCTCAGGTCCCCAC CGTGCCTGTGCCACCGGCTGCGGTCCTCTCGCCGCCTCTGCCGGAAGTGCTGCTGCCTGCCGCCCCTGAGCTCCTGCCTCAGTTCCCCAG CTCCCTGGCCACGGTGTCTGCCTCTGTGCAGAGTGTGCCCACCCAGACTGCCACACTTCTGCCACCAGCAAACCCACCGCTGCCTGGCGG GCCCGGGATCGCCAGCCCTTGCCCAACTGTCCAGCTGACGGTGGAACCAGTCCAAGAGGAGCAGGCCTCACAGGACAAGCCGCCCGGCCT CCCGCAGAGCTGTGAGAGCTATGGAGGTTCTGATGTCACTTCTGGAAAAGAGCTGAGTGACAGCTGTGAAGGCGCCTTTGGAGGGGGCAG GCTGGAGGGCAGGGCAGCCCGAAAACACCACCGCAGGTCCACGCGTGCGCGCTCCCGGCAGGAGAGGGCCAGCCGGCCCCGGCTTACCAT CTTGAACGTGTGCAACACTGGGGACAAGATGGTGGAGTGCCAGCTGGAGACGCACAACCACAAGATGGTGACCTTCAAGTTCGACTTGGA CGGGGACGCACCCGATGAAATTGCCACGTATATGGTGGAGCATGACTTTATCCTGCAGGCCGAGCGGGAAACGTTCATCGAGCAGATGAA GGATGTCATGGACAAGGCAGAGGACATGCTCAGCGAGGACACAGACGCCGACCGTGGCTCCGACCCAGGGACCAGCCCGCCACACCTCAG CACCTGCGGCCTGGGCACCGGGGAGGAGAGCCGACAATCCCAAGCCAACGCCCCCGTGTATCAGCAGAACGTCCTGCACACCGGGAAGAG GTGGTTCATCATCTGTCCGGTGGCTGAGCACCCCGCCCCCGAGGCCCCTGAATCTTCGCCCCCACTTCCTCTAAGCTCCCTGCCGCCAGA AGCCAGCCAAGATTCAGCGCCCTATAAAGACCAGCTGTCCTCGAAGGAACAACCCAGCTTTCTAGCCAGTCAGCAGCTCCTGAGCCAGGC GGGCCCCAGCAACCCTCCTGGGGCACCCCCAGCCCCTTTGGCCCCCTCCTCCCCTCCTGTGACTGCTCTGCCCCAAGATGGAGCAGCTCC AGCCACCAGCACCATGCCAGAGCCAGCGTCAGGAACTGCCAGCCAGGCAGGGGGTCCAGGGACACCTCAGGGGCTGACCAGTGAGCTCGA GACGTCTCAGCCACTAGCGGAGACTCACGAGGCCCCGCTTGCTGTGCAGCCCCTCGTGGTGGGCCTAGCACCTTGCACTCCAGCTCCAGA GGCTGCCTCAACCAGGGACGCCAGTGCCCCAAGGGAGCCCCTGCCACCTCCTGCACCTGAGCCCAGCCCCCACAGCGGGACCCCACAGCC CGCCTTGGGTCAACCTGCTCCCCTGCTTCCTGCCGCAGTGGGGGCCGTCAGCCTGGCCACCTCCCAGCTCCCAAGCCCACCCCTGGGGCC CACCGTCCCCCCACAGCCACCCTCGGCCCTGGAGTCGGATGGGGAAGGGCCGCCCCCCAGGGTGGGCTTTGTGGACAGCACCATCAAGAG CCTGGACGAGAAGCTGCGGACTCTGCTCTACCAGGAGCACGTGCCCACCTCCTCAGCCTCAGCTGGGACCCCTGTGGAGGTGGGCGACAG AGACTTCACCCTGGAGCCCCTGAGAGGGGACCAGCCCCGCTCAGAGGTCTGCGGGGGGGACCTGGCCCTGCCCCCAGTGCCTAAGGAGGC GGTCTCAGGGCGTGTCCAGCTGCCCCAGCCCTTGGTGGAGAAGTCAGAACTGGCCCCCACTCGAGGGGCCGTGATGGAGCAGGGCACGTC CTCGTCAATGACAGCAGAGTCGTCTCCCAGGAGTATGCTAGGCTATGACAGAGATGGAAGGCAGGTGGCCTCAGACTCCCATGTGGTCCC CAGCGTCCCCCAGGATGTACCTGCTTTTGTGAGACCTGCACGTGTGGAGCCCACAGACAGGGATGGTGGAGAAGCTGGAGAAAGCTCGGC AGAGCCCCCGCCGAGTGACATGGGCACAGTGGGGGGCCAGGCTAGCCACCCCCAGACACTCGGCGCTCGAGCTTTGGGGTCCCCTCGGAA ACGTCCAGAGCAGCAGGATGTCAGCTCACCAGCCAAGACTGTGGGCCGTTTCTCGGTGGTCAGCACTCAGGACGAGTGGACCCTGGCCTC CCCCCACAGCCTGAGATACTCTGCCCCACCCGACGTCTACCTGGACGAGGCCCCCTCCAGCCCCGACGTGAAGCTGGCAGTGCGGCGGGC GCAGACGGCCTCCTCCATCGAGGTCGGCGTGGGCGAGCCCGTGTCCAGCGACTCTGGGGACGAGGGCCCTCGGGCGAGACCCCCGGTGCA GAAGCAGGCGTCCCTGCCCGTGAGTGGCAGCGTGGCTGGCGACTTCGTGAAGAAGGCCACCGCCTTCCTGCAGAGGCCTTCTCGGGCCGG CTCGCTGGGCCCCGAGACACCCAGCAGGGTGGGCATGAAGGTCCCCACGATCAGCGTGACCTCCTTCCATTCCCAGTCGTCCTACATCAG CAGCGACAATGATTCGGAGCTCGAGGATGCTGACATAAAGAAGGAGCTGCAGAGTCTGCGGGAGAAGCACCTGAAGGAGATCTCGGAGCT GCAGAGCCAGCAGAAGCAGGAGATCGAAGCTCTGTACCGCCGCCTGGGCAAGCCACTGCCCCCCAACGTGGGCTTCTTCCACACGGCACC CCCCACTGGCCGCCGGAGAAAAACCAGCAAGAGCAAGCTGAAGGCAGGCAAGCTGCTAAATCCCCTGGTGCGGCAGCTCAAGGTCGTGGC CTCCAGCACAGGTCACTTGGCTGACTCCAGCAGAGGCCCTCCCGCTAAGGACCCTGCCCAAGCCAGTGTGGGGCTCACTGCAGACAGCAC GGGCCTGAGCGGGAAGGCAGTGCAGACCCAGCAGCCCTGCTCCGTCCGGGCCTCCCTGTCTTCGGACATCTGCTCCGGCTTAGCCAGTGA TGGAGGCGGAGCGCGTGGCCAAGGCTGGACGGTTTACCACCCAACGTCTGAGAGAGTGACCTATAAGTCTAGTAGCAAACCTCGTGCTCG ATTCCTCAGTGGACCCGTATCTGTGTCCATCTGGTCTGCCCTGAAGCGTCTCTGCCTAGGCAAAGAACACAGCAGTAGGTCCTCCACCAG CAGCCTGGCCCCAGGCCCTGAGCCAGGCCCCCAGCCCGCCCTGCACGTCCAGGCGCAGGTGAACAACAGCAACAACAAGAAGGGTACCTT CACGGACGACCTGCACAAGCTGGTGGACGAGTGGACGAGCAAGACGGTGGGGGCCGCGCAGCTGAAGCCCACGCTCAACCAGCTGAAGCA GACCCAGAAGCTGCAAGACATGGAGGCCCAGGCAGGCTGGGCTGCCCCTGGCGAGGCGCGGGCTATGACCGCACCTCGAGCAGGAGTGGG GATGCCACGTCTGCCCCCAGCGCCCGGCCCTCTGTCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGATCC TGAGAGTGAGAAGCCTGACTGACCCCGCCTAGACGCCAGGCCCACTTCACGCCGTCTAAGTGGAGAAGTGACGGACCCTCAGGGCCAGCT GCTCCTCCTGTCCAGTTCACGCTGTTTTGTAACCACTTTCTAAGCATTTTTTATTCACAATTGGAAACACAAATGTAATGCAAGAATAAA >In-frame_ENST00000210444_ENST00000395475_TCGA-ZG-A9LN-01A_NANS_chr9_100823279_+_WNK2_chr9_96019230_length(amino acids)=1603AA_start in transcript=70_stop in transcript=4881 MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEF SHDQYRELQRYAEEVGIFFTASGMDEPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQ MPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATI PLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTR PPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPE LLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSGKELSDSCE GAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERE TFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPPLP LSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQ GLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQL PSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLAL PPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGG EAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDV KLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFH SQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLV RQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTSERVTYKS SSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NANS-WNK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NANS-WNK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NANS-WNK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NANS | C0005941 | Bone Diseases, Developmental | 1 | CTD_human |
| Hgene | NANS | C0008073 | Developmental Disabilities | 1 | CTD_human |
| Hgene | NANS | C0085996 | Child Development Deviations | 1 | CTD_human |
| Hgene | NANS | C0085997 | Child Development Disorders, Specific | 1 | CTD_human |
| Hgene | NANS | C1864872 | Spondyloepimetaphyseal dysplasia, Genevieve type | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
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