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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NAP1L4-ATP11B (FusionGDB2 ID:56854)

Fusion Gene Summary for NAP1L4-ATP11B

check button Fusion gene summary
Fusion gene informationFusion gene name: NAP1L4-ATP11B
Fusion gene ID: 56854
HgeneTgene
Gene symbol

NAP1L4

ATP11B

Gene ID

4676

23200

Gene namenucleosome assembly protein 1 like 4ATPase phospholipid transporting 11B (putative)
SynonymsNAP1L4b|NAP2|NAP2L|hNAP2ATPIF|ATPIR
Cytomap

11p15.4

3q26.33

Type of geneprotein-codingprotein-coding
Descriptionnucleosome assembly protein 1-like 4NAP-2nucleosome assembly protein 1-like 4bnucleosome assembly protein 2probable phospholipid-transporting ATPase IFATPase IRATPase, class VI, type 11BP4-ATPase flippase complex alpha subunit ATP11Btruncated ATPase 11B protein
Modification date2020032220200313
UniProtAcc

Q99733

Q9Y2G3

Ensembl transtripts involved in fusion geneENST00000380542, ENST00000469089, 
ENST00000526115, 		ENST00000323116, 
ENST00000493826, ENST00000482794, 
Fusion gene scores* DoF score13 X 18 X 7=163812 X 11 X 4=528
# samples 1814
** MAII scorelog2(18/1638*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/528*10)=-1.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NAP1L4 [Title/Abstract] AND ATP11B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNAP1L4(2985910)-ATP11B(182631649), # samples:3
Anticipated loss of major functional domain due to fusion event.NAP1L4-ATP11B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NAP1L4-ATP11B seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NAP1L4-ATP11B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
NAP1L4-ATP11B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNAP1L4

GO:0006334

nucleosome assembly

9325046


check buttonFusion gene breakpoints across NAP1L4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ATP11B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-FC-A4JI-01ANAP1L4chr11

2985910

-ATP11Bchr3

182631649

+
ChimerDB4PRADTCGA-FC-A4JINAP1L4chr11

2985909

-ATP11Bchr3

182631648

+
ChimerDB4PRADTCGA-FC-A4JINAP1L4chr11

2985909

-ATP11Bchr3

182631648

+
ChimerDB4PRADTCGA-FC-A4JINAP1L4chr11

2985910

-ATP11Bchr3

182631649

+
ChimerDB4PRADTCGA-FC-A4JI-01ANAP1L4chr11

2985910

-ATP11Bchr3

182631649

+


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Fusion Gene ORF analysis for NAP1L4-ATP11B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000380542ENST00000323116NAP1L4chr11

2985910

-ATP11Bchr3

182631649

+
5CDS-intronENST00000380542ENST00000493826NAP1L4chr11

2985910

-ATP11Bchr3

182631649

+
5CDS-intronENST00000380542ENST00000482794NAP1L4chr11

2985910

-ATP11Bchr3

182631649

+
intron-3CDSENST00000469089ENST00000323116NAP1L4chr11

2985910

-ATP11Bchr3

182631649

+
intron-intronENST00000469089ENST00000493826NAP1L4chr11

2985910

-ATP11Bchr3

182631649

+
intron-intronENST00000469089ENST00000482794NAP1L4chr11

2985910

-ATP11Bchr3

182631649

+
In-frameENST00000526115ENST00000323116NAP1L4chr11

2985910

-ATP11Bchr3

182631649

+
5CDS-intronENST00000526115ENST00000493826NAP1L4chr11

2985910

-ATP11Bchr3

182631649

+
5CDS-intronENST00000526115ENST00000482794NAP1L4chr11

2985910

-ATP11Bchr3

182631649

+
Frame-shiftENST00000380542ENST00000323116NAP1L4chr11

2985909

-ATP11Bchr3

182631648

+
5CDS-intronENST00000380542ENST00000493826NAP1L4chr11

2985909

-ATP11Bchr3

182631648

+
5CDS-intronENST00000380542ENST00000482794NAP1L4chr11

2985909

-ATP11Bchr3

182631648

+
intron-3CDSENST00000469089ENST00000323116NAP1L4chr11

2985909

-ATP11Bchr3

182631648

+
intron-intronENST00000469089ENST00000493826NAP1L4chr11

2985909

-ATP11Bchr3

182631648

+
intron-intronENST00000469089ENST00000482794NAP1L4chr11

2985909

-ATP11Bchr3

182631648

+
In-frameENST00000526115ENST00000323116NAP1L4chr11

2985909

-ATP11Bchr3

182631648

+
5CDS-intronENST00000526115ENST00000493826NAP1L4chr11

2985909

-ATP11Bchr3

182631648

+
5CDS-intronENST00000526115ENST00000482794NAP1L4chr11

2985909

-ATP11Bchr3

182631648

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000526115NAP1L4chr112985910-ENST00000323116ATP11Bchr3182631649+46378902841105273
ENST00000526115NAP1L4chr112985909-ENST00000323116ATP11Bchr3182631648+46378902841105273

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000526115ENST00000323116NAP1L4chr112985910-ATP11Bchr3182631649+0.0004885720.9995115
ENST00000526115ENST00000323116NAP1L4chr112985909-ATP11Bchr3182631648+0.0004885720.9995115

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Fusion Genomic Features for NAP1L4-ATP11B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NAP1L4chr112985909-ATP11Bchr3182631648+0.0015768540.9984232
NAP1L4chr112985909-ATP11Bchr3182631648+0.0015768540.9984232
NAP1L4chr112985909-ATP11Bchr3182631648+0.0015768540.9984232
NAP1L4chr112985909-ATP11Bchr3182631648+0.0015768540.9984232

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NAP1L4-ATP11B


check button Go to

FGviewer for the breakpoints of chr11:2985910-chr3:182631649

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NAP1L4

Q99733

ATP11B

Q9Y2G3

FUNCTION: Acts as histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}.FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269|PubMed:30018401}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAP1L4chr11:2985909chr3:182631648ENST00000380542-816126_131202.0740.3333333333334Compositional biasNote=Poly-Glu
HgeneNAP1L4chr11:2985910chr3:182631649ENST00000380542-816126_131202.0740.3333333333334Compositional biasNote=Poly-Glu
TgeneATP11Bchr11:2985909chr3:182631648ENST00000493826061021_10250196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST00000493826061048_10650196.0Topological domainExtracellular
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606105_2890196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST00000493826061091_11770196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST00000493826061_550196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606312_3410196.0Topological domainExtracellular
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606360_8760196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST000004938260678_820196.0Topological domainExtracellular
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606899_9100196.0Topological domainExtracellular
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606931_9600196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606983_9970196.0Topological domainExtracellular
TgeneATP11Bchr11:2985910chr3:182631649ENST00000493826061021_10250196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST00000493826061048_10650196.0Topological domainExtracellular
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606105_2890196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST00000493826061091_11770196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST00000493826061_550196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606312_3410196.0Topological domainExtracellular
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606360_8760196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST000004938260678_820196.0Topological domainExtracellular
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606899_9100196.0Topological domainExtracellular
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606931_9600196.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606983_9970196.0Topological domainExtracellular
TgeneATP11Bchr11:2985909chr3:182631648ENST00000493826061026_10470196.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST00000493826061066_10900196.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606290_3110196.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606342_3590196.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST000004938260656_770196.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST000004938260683_1040196.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606877_8980196.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606911_9300196.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606961_9820196.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST0000049382606998_10200196.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST00000493826061026_10470196.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST00000493826061066_10900196.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606290_3110196.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606342_3590196.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST000004938260656_770196.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST000004938260683_1040196.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606877_8980196.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606911_9300196.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606961_9820196.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST0000049382606998_10200196.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNAP1L4chr11:2985909chr3:182631648ENST00000380542-816301_310202.0740.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNAP1L4chr11:2985909chr3:182631648ENST00000380542-816347_370202.0740.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNAP1L4chr11:2985910chr3:182631649ENST00000380542-816301_310202.0740.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNAP1L4chr11:2985910chr3:182631649ENST00000380542-816347_370202.0740.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
HgeneNAP1L4chr11:2985909chr3:182631648ENST00000380542-816265_271202.0740.3333333333334MotifNuclear localization signal
HgeneNAP1L4chr11:2985910chr3:182631649ENST00000380542-816265_271202.0740.3333333333334MotifNuclear localization signal
TgeneATP11Bchr11:2985909chr3:182631648ENST0000032311627301021_10251106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST0000032311627301048_10651106.01178.0Topological domainExtracellular
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730105_2891106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST0000032311627301091_11771106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST0000032311627301_551106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730312_3411106.01178.0Topological domainExtracellular
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730360_8761106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST00000323116273078_821106.01178.0Topological domainExtracellular
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730899_9101106.01178.0Topological domainExtracellular
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730931_9601106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730983_9971106.01178.0Topological domainExtracellular
TgeneATP11Bchr11:2985910chr3:182631649ENST0000032311627301021_10251106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST0000032311627301048_10651106.01178.0Topological domainExtracellular
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730105_2891106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST0000032311627301091_11771106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST0000032311627301_551106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730312_3411106.01178.0Topological domainExtracellular
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730360_8761106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST00000323116273078_821106.01178.0Topological domainExtracellular
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730899_9101106.01178.0Topological domainExtracellular
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730931_9601106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730983_9971106.01178.0Topological domainExtracellular
TgeneATP11Bchr11:2985909chr3:182631648ENST0000032311627301026_10471106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST0000032311627301066_10901106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730290_3111106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730342_3591106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST00000323116273056_771106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST00000323116273083_1041106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730877_8981106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730911_9301106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730961_9821106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985909chr3:182631648ENST000003231162730998_10201106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST0000032311627301026_10471106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST0000032311627301066_10901106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730290_3111106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730342_3591106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST00000323116273056_771106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST00000323116273083_1041106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730877_8981106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730911_9301106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730961_9821106.01178.0TransmembraneHelical
TgeneATP11Bchr11:2985910chr3:182631649ENST000003231162730998_10201106.01178.0TransmembraneHelical


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Fusion Gene Sequence for NAP1L4-ATP11B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000526115_ENST00000323116_TCGA-FC-A4JI-01A_NAP1L4_chr11_2985910_-_ATP11B_chr3_182631649_length(transcript)=4637nt_BP=890nt
CTTGCTCGCGGAGAGAGGAGCTAGGAGCCTCGGCCAATGGGAGCCGGCGTTGTTGGAGGCCACGGCGGCGCAGCCCCAAAGCGAGCGAAG
CTAGGGTCGCCGCCACTGCCGCAGGAGGCGTGAGGGAAAAGTGTTTTAGGCTTCCAGAGTAGAAATCTGATATTACTTCGTTTGATTCTT
CGACCACTATGGTGATAGGAAGTAGCTGATCTCTGCAGGAAACTGCTGTTACCTGGCCTCAGCTGAATTTTTGTGGGACCTCCTGAGGGG
ATAAAAACATTCAGATGGCAGATCACAGTTTTTCAGATGGGGTTCCTTCAGATTCCGTGGAAGCTGCTAAAAATGCAAGTAACACAGAAA
AGCTCACAGATCAGGTGATGCAGAATCCTCGAGTTCTGGCAGCTTTACAGGAGCGACTTGACAATGTCCCTCACACCCCTTCCAGCTACA
TCGAAACTTTACCTAAAGCAGTAAAAAGAAGAATTAATGCATTGAAACAACTTCAGGTGAGATGTGCTCACATAGAAGCCAAGTTCTATG
AAGAGGTACATGACTTGGAAAGAAAGTATGCAGCGCTATACCAGCCTCTCTTTGACAAGAGAAGAGAATTTATCACCGGCGATGTTGAAC
CAACAGATGCGGAATCGGAATGGCACAGTGAAAATGAAGAGGAAGAGAAATTGGCTGGAGACATGAAAAGTAAAGTAGTCGTCACAGAAA
AAGCAGCGGCAACGGCTGAAGAGCCAGATCCCAAAGGAATTCCAGAGTTCTGGTTTACCATCTTCAGAAATGTGGACATGCTGAGTGAAT
TAGTCCAGGAATATGATGAACCAATCTTGAAACACCTGCAGGATATTAAAGTGAAATTTTCTGACCCTGGACAGCCTATGCTTACTGAAA
CAAATGCAGGTATCAAGTGCTTGGACTCCATGTGCTGTTTCCCGGAAGGAGAAGCAGCGTGTGCATCTGTTGGAAGAATGCTGGAACGAG
TTATAGGAAGATGTAGTCCAACCCACATCAGCAGATCATGGAGTGCATCGGATCCTTTCTATACCAACGACAGGAGCATCTTGACTCTCT
CCACAATGGACTCATCTACTTGTTAAAGGGGCAGTAGTACTTTGTGGGAGCCAGTTCACCTCCTTTCCTAAAATTCAGTGTGATCACCCT
GTTAATGGCCACACTAGCTCTGAAATTAATTTCCAAAATCTTTGTAGTAGTTCATACCCACTCAGAGTTATAATGGCAAACAAACAGAAA
GCATTAGTACAAGCCCCTCCCAACACCCTTAATTTGAATCTGAACATGTTAAAATTTGAGAATAAAGAGACATTTTTCATCTCTTTGTCT
GGTTTGTCCCTTGTGCTTATGGGACTCCTAATGGCATTTCAGTCTGTTGCTGAGGCCATTATATTTTAATATAAATGTAGAAAAAAGAGA
GAAATCTTAGTAAAGAGTATTTTTTAGTATTAGCTTGATTATTGACTCTTCTATTTAAATCTGCTTCTGTAAATTATGCTGAAAGTTTGC
CTTGAGAACTCTATTTTTTTATTAGAGTTATATTTAAAGCTTTTCATGGGAAAAGTTAATGTGAATACTGAGGAATTTTGGTCCCTCAGT
GACCTGTGTTGTTAATTCATTAATGCATTCTGAGTTCACAGAGCAAATTAGGAGAATCATTTCCAACCATTATTTACTGCAGTATGGGGA
GTAAATTTATACCAATTCCTCTAACTGTACTGTAACACAGCCTGTAAAGTTAGCCATATAAATGCAAGGGTATATCATATATACAAATCA
GGAATCAGGTCCGTTCACCGAACTTCAAATTGATGTTTACTAATATTTTTGTGACAGAGTATAAAGACCCTATAGTGGGTAAATTAGATA
CTATTAGCATATTATTAATTTAATGTCTTTATCATTGGATCTTTTGCATGCTTTAATCTGGTTAACATATTTAAATTTGCTTTTTTTCTC
TTTACCTGAAGGCTCTGTGTATAGTATTTCATGACATCGTTGTACAGTTTAACTATATCAATAAAAAGTTTGGACAGTATTTAAATATTG
CAAATATGTTTAATTATACAAATCAGAATAGTATGGGTAATTAAATGAATACAAAAAGAAGAGCCTCTTTCTGCAGCCGACTTAGACATG
CTCTTCCCTTTCTATAAGCTAGATTTTAGAATAAAGGGTTTCAGTTAATAATCTTATTTTCAGGTTATGTCATCTAACTTATAGCAAACT
ACCACAATACAGTGAGTTCTGCCAGTGTCCCAGTACAAGGCATATTTCAGGTGTGGCTGTGGAATGTAAAAATGCTCAACTTGTATCAGG
TAATGTTAGCAATAAATTAAATGCTAAGAATGATTAATCGGGTACATGTTACTGTAATTAACTCATTGCACTTCAAAACCTAACTTCCAT
CCTGAATTTATCAAGTAGTTCAGTATTGTCATTTGTTTTTGTTTTATTGAAAAGTAATGTTGTCTTAAGATTTAGAAGTGATTATTAGCT
TGAGAACTATTACCCAGCTCTAAGCAAATAATGATTGTATACATATTAAGATAATGGTTAAATGCGGTTTTACCAAGTTTTCCCTTGAAA
ATGTAATTCCTTTATGGAGATTTATTGTGCAGCCCTAAGCTTCCTTCCCATTTCATGAATATAAGGCTTCTAGAATTGGACTGGCAGGGG
AAAGAATGGTAGAGACAGAAATTAAGACTTTATCCTTGTTTGCTTGTAAACTATTATTTTCTTGCTAATGTAACATTTGTCTGTTCCAGT
GATGTAAGGATATTAAGTTATTAAGCTAAATATTAATTTTCAAAAATAGTCCTTCTTTAACTTAGATATTTCATAGCTGGATTTAGGAAG
ATCTGTTATTCTGGAAGTACTAAAAAGAATAATACAACGTACAATGTCTGCATTCACTAATTCATGTTCCAGAAGAGGAAATAATGAAGA
TATACTCAGTAGAGTACTAGGTGGGAGGATATGGAAATTTGCTCATAAAATCTCTTATAAAACGTGCATATAACAAAATGACACCCAGTA
GGCCTGCATTACATTTACATGACCGTGTTTATTTGCCATCAAATAAACTGAGTACTGACACCAGACAAAGACTCCAAAGTCATAAAATAG
CCTATGACCAACTGCAGCAAGACAGGAGGTCAGCTCGCCTATAATGGTGCTTAAAGTGTGATTGATGTAATTTTCTGTACTCACCATTTG
AAGTTAGTTAAGGAGAACTTTATTTTTTTAAAAAAAGTAAATGGCAACCACTAGTGTGCTCATCCTGAACTGTTACTCCAAATCCACTCC
GTTTTTAAAGCAAAATTATCTTGTGATTTTAAGAAAAGAGTTTTCTATTTATTTAAGAAAGTAACAATGCAGTCTGCAAGCTTTCAGTAG
TTTTCTAGTGCTATATTCATCCTGTAAAACTCTTACTACGTAACCAGTAATCACAAGGAAAGTGTCCCCTTTGCATATTTCTTTAAAATT
CTTTCTTTGGAAAGTATGATGTTGATAATTAACTTACCCTTATCTGCCAAAACCAGAGCAAAATGCTAAATACGTTATTGCTAATCAGTG
GTCTCAAATCGATTTGCCTCCCTTTGCCTCGTCTGAGGGCTGTAAGCCTGAAGATAGTGGCAAGCACCAAGTCAGTTTCCAAAATTGCCC
CTCAGCTGCTTTAAGTGACTCAGCACCCTGCCTCAGCTTCAGCAGGCGTAGGCTCACCCTGGGCGGAGCAAAGTATGGGCCAGGGAGAAC
TACAGCTACGAAGACCTGCTGTCGAGTTGAGAAAAGGGGAGAATTTATGGTCTGAATTTTCTAACTGTCCTCTTTCTTGGGTCTAAAGCT
CATAATACACAAAGGCTTCCAGACCTGAGCCACACCCAGGCCCTATCCTGAACAGGAGACTAAACAGAGGCAAATCAACCCTAGGAAATA
CTTGCATTCTGCCCTACGGTTAGTACCAGGACTGAGGTCATTTCTACTGGAAAAGATTGTGAGATTGAACTTATCTGATCGCTTGAGACT
CCTAATAGGCAGGAGTCAAGGCCACTAGAAAATTGACAGTTAAGAGCCAAAAGTTTTTAAAATATGCTACTCTGAAAAATCTCGTGAAGG
CTGTAGGAAAAGGGAGAATCTTCCATGTTGGTGTTTTTCCTGTAAAGATCAGTTTGGGGTATGATATAAGCAGGTATTAATAAAAATAAC
ACACCAAAGAGTTACGTAAAACATGTTTTATTAATTTTGGTCCCCACGTACAGACATTTTATTTCTATTTTGAAATGAGTTATCTATTTT
CATAAAAGTAAAACACTATTAAAGTGCTGTTTTATGTGAAATAACTTGAATGTTGTTCCTATAAAAAATAGATCATAACTCATGATATGT
TTGTAATCATGGTAATTTAGATTTTTATGAGGAATGAGTATCTGGAAATATTGTAGCAATACTTGGTTTAAAATTTTGGACCTGAGACAC
TGTGGCTGTCTAATGTAATCCTTTAAAAATTCTCTGCATTGTCAGTAAATGTAGTATATTATTGTACAGCTACTCATAATTTTTTAAAGT

>In-frame_ENST00000526115_ENST00000323116_TCGA-FC-A4JI-01A_NAP1L4_chr11_2985910_-_ATP11B_chr3_182631649_length(amino acids)=273AA_start in transcript=284_stop in transcript=1105
MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHD
LERKYAALYQPLFDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEY
DEPILKHLQDIKVKFSDPGQPMLTETNAGIKCLDSMCCFPEGEAACASVGRMLERVIGRCSPTHISRSWSASDPFYTNDRSILTLSTMDS

--------------------------------------------------------------
>In-frame_ENST00000526115_ENST00000323116_TCGA-FC-A4JI_NAP1L4_chr11_2985909_-_ATP11B_chr3_182631648_length(transcript)=4637nt_BP=890nt
CTTGCTCGCGGAGAGAGGAGCTAGGAGCCTCGGCCAATGGGAGCCGGCGTTGTTGGAGGCCACGGCGGCGCAGCCCCAAAGCGAGCGAAG
CTAGGGTCGCCGCCACTGCCGCAGGAGGCGTGAGGGAAAAGTGTTTTAGGCTTCCAGAGTAGAAATCTGATATTACTTCGTTTGATTCTT
CGACCACTATGGTGATAGGAAGTAGCTGATCTCTGCAGGAAACTGCTGTTACCTGGCCTCAGCTGAATTTTTGTGGGACCTCCTGAGGGG
ATAAAAACATTCAGATGGCAGATCACAGTTTTTCAGATGGGGTTCCTTCAGATTCCGTGGAAGCTGCTAAAAATGCAAGTAACACAGAAA
AGCTCACAGATCAGGTGATGCAGAATCCTCGAGTTCTGGCAGCTTTACAGGAGCGACTTGACAATGTCCCTCACACCCCTTCCAGCTACA
TCGAAACTTTACCTAAAGCAGTAAAAAGAAGAATTAATGCATTGAAACAACTTCAGGTGAGATGTGCTCACATAGAAGCCAAGTTCTATG
AAGAGGTACATGACTTGGAAAGAAAGTATGCAGCGCTATACCAGCCTCTCTTTGACAAGAGAAGAGAATTTATCACCGGCGATGTTGAAC
CAACAGATGCGGAATCGGAATGGCACAGTGAAAATGAAGAGGAAGAGAAATTGGCTGGAGACATGAAAAGTAAAGTAGTCGTCACAGAAA
AAGCAGCGGCAACGGCTGAAGAGCCAGATCCCAAAGGAATTCCAGAGTTCTGGTTTACCATCTTCAGAAATGTGGACATGCTGAGTGAAT
TAGTCCAGGAATATGATGAACCAATCTTGAAACACCTGCAGGATATTAAAGTGAAATTTTCTGACCCTGGACAGCCTATGCTTACTGAAA
CAAATGCAGGTATCAAGTGCTTGGACTCCATGTGCTGTTTCCCGGAAGGAGAAGCAGCGTGTGCATCTGTTGGAAGAATGCTGGAACGAG
TTATAGGAAGATGTAGTCCAACCCACATCAGCAGATCATGGAGTGCATCGGATCCTTTCTATACCAACGACAGGAGCATCTTGACTCTCT
CCACAATGGACTCATCTACTTGTTAAAGGGGCAGTAGTACTTTGTGGGAGCCAGTTCACCTCCTTTCCTAAAATTCAGTGTGATCACCCT
GTTAATGGCCACACTAGCTCTGAAATTAATTTCCAAAATCTTTGTAGTAGTTCATACCCACTCAGAGTTATAATGGCAAACAAACAGAAA
GCATTAGTACAAGCCCCTCCCAACACCCTTAATTTGAATCTGAACATGTTAAAATTTGAGAATAAAGAGACATTTTTCATCTCTTTGTCT
GGTTTGTCCCTTGTGCTTATGGGACTCCTAATGGCATTTCAGTCTGTTGCTGAGGCCATTATATTTTAATATAAATGTAGAAAAAAGAGA
GAAATCTTAGTAAAGAGTATTTTTTAGTATTAGCTTGATTATTGACTCTTCTATTTAAATCTGCTTCTGTAAATTATGCTGAAAGTTTGC
CTTGAGAACTCTATTTTTTTATTAGAGTTATATTTAAAGCTTTTCATGGGAAAAGTTAATGTGAATACTGAGGAATTTTGGTCCCTCAGT
GACCTGTGTTGTTAATTCATTAATGCATTCTGAGTTCACAGAGCAAATTAGGAGAATCATTTCCAACCATTATTTACTGCAGTATGGGGA
GTAAATTTATACCAATTCCTCTAACTGTACTGTAACACAGCCTGTAAAGTTAGCCATATAAATGCAAGGGTATATCATATATACAAATCA
GGAATCAGGTCCGTTCACCGAACTTCAAATTGATGTTTACTAATATTTTTGTGACAGAGTATAAAGACCCTATAGTGGGTAAATTAGATA
CTATTAGCATATTATTAATTTAATGTCTTTATCATTGGATCTTTTGCATGCTTTAATCTGGTTAACATATTTAAATTTGCTTTTTTTCTC
TTTACCTGAAGGCTCTGTGTATAGTATTTCATGACATCGTTGTACAGTTTAACTATATCAATAAAAAGTTTGGACAGTATTTAAATATTG
CAAATATGTTTAATTATACAAATCAGAATAGTATGGGTAATTAAATGAATACAAAAAGAAGAGCCTCTTTCTGCAGCCGACTTAGACATG
CTCTTCCCTTTCTATAAGCTAGATTTTAGAATAAAGGGTTTCAGTTAATAATCTTATTTTCAGGTTATGTCATCTAACTTATAGCAAACT
ACCACAATACAGTGAGTTCTGCCAGTGTCCCAGTACAAGGCATATTTCAGGTGTGGCTGTGGAATGTAAAAATGCTCAACTTGTATCAGG
TAATGTTAGCAATAAATTAAATGCTAAGAATGATTAATCGGGTACATGTTACTGTAATTAACTCATTGCACTTCAAAACCTAACTTCCAT
CCTGAATTTATCAAGTAGTTCAGTATTGTCATTTGTTTTTGTTTTATTGAAAAGTAATGTTGTCTTAAGATTTAGAAGTGATTATTAGCT
TGAGAACTATTACCCAGCTCTAAGCAAATAATGATTGTATACATATTAAGATAATGGTTAAATGCGGTTTTACCAAGTTTTCCCTTGAAA
ATGTAATTCCTTTATGGAGATTTATTGTGCAGCCCTAAGCTTCCTTCCCATTTCATGAATATAAGGCTTCTAGAATTGGACTGGCAGGGG
AAAGAATGGTAGAGACAGAAATTAAGACTTTATCCTTGTTTGCTTGTAAACTATTATTTTCTTGCTAATGTAACATTTGTCTGTTCCAGT
GATGTAAGGATATTAAGTTATTAAGCTAAATATTAATTTTCAAAAATAGTCCTTCTTTAACTTAGATATTTCATAGCTGGATTTAGGAAG
ATCTGTTATTCTGGAAGTACTAAAAAGAATAATACAACGTACAATGTCTGCATTCACTAATTCATGTTCCAGAAGAGGAAATAATGAAGA
TATACTCAGTAGAGTACTAGGTGGGAGGATATGGAAATTTGCTCATAAAATCTCTTATAAAACGTGCATATAACAAAATGACACCCAGTA
GGCCTGCATTACATTTACATGACCGTGTTTATTTGCCATCAAATAAACTGAGTACTGACACCAGACAAAGACTCCAAAGTCATAAAATAG
CCTATGACCAACTGCAGCAAGACAGGAGGTCAGCTCGCCTATAATGGTGCTTAAAGTGTGATTGATGTAATTTTCTGTACTCACCATTTG
AAGTTAGTTAAGGAGAACTTTATTTTTTTAAAAAAAGTAAATGGCAACCACTAGTGTGCTCATCCTGAACTGTTACTCCAAATCCACTCC
GTTTTTAAAGCAAAATTATCTTGTGATTTTAAGAAAAGAGTTTTCTATTTATTTAAGAAAGTAACAATGCAGTCTGCAAGCTTTCAGTAG
TTTTCTAGTGCTATATTCATCCTGTAAAACTCTTACTACGTAACCAGTAATCACAAGGAAAGTGTCCCCTTTGCATATTTCTTTAAAATT
CTTTCTTTGGAAAGTATGATGTTGATAATTAACTTACCCTTATCTGCCAAAACCAGAGCAAAATGCTAAATACGTTATTGCTAATCAGTG
GTCTCAAATCGATTTGCCTCCCTTTGCCTCGTCTGAGGGCTGTAAGCCTGAAGATAGTGGCAAGCACCAAGTCAGTTTCCAAAATTGCCC
CTCAGCTGCTTTAAGTGACTCAGCACCCTGCCTCAGCTTCAGCAGGCGTAGGCTCACCCTGGGCGGAGCAAAGTATGGGCCAGGGAGAAC
TACAGCTACGAAGACCTGCTGTCGAGTTGAGAAAAGGGGAGAATTTATGGTCTGAATTTTCTAACTGTCCTCTTTCTTGGGTCTAAAGCT
CATAATACACAAAGGCTTCCAGACCTGAGCCACACCCAGGCCCTATCCTGAACAGGAGACTAAACAGAGGCAAATCAACCCTAGGAAATA
CTTGCATTCTGCCCTACGGTTAGTACCAGGACTGAGGTCATTTCTACTGGAAAAGATTGTGAGATTGAACTTATCTGATCGCTTGAGACT
CCTAATAGGCAGGAGTCAAGGCCACTAGAAAATTGACAGTTAAGAGCCAAAAGTTTTTAAAATATGCTACTCTGAAAAATCTCGTGAAGG
CTGTAGGAAAAGGGAGAATCTTCCATGTTGGTGTTTTTCCTGTAAAGATCAGTTTGGGGTATGATATAAGCAGGTATTAATAAAAATAAC
ACACCAAAGAGTTACGTAAAACATGTTTTATTAATTTTGGTCCCCACGTACAGACATTTTATTTCTATTTTGAAATGAGTTATCTATTTT
CATAAAAGTAAAACACTATTAAAGTGCTGTTTTATGTGAAATAACTTGAATGTTGTTCCTATAAAAAATAGATCATAACTCATGATATGT
TTGTAATCATGGTAATTTAGATTTTTATGAGGAATGAGTATCTGGAAATATTGTAGCAATACTTGGTTTAAAATTTTGGACCTGAGACAC
TGTGGCTGTCTAATGTAATCCTTTAAAAATTCTCTGCATTGTCAGTAAATGTAGTATATTATTGTACAGCTACTCATAATTTTTTAAAGT

>In-frame_ENST00000526115_ENST00000323116_TCGA-FC-A4JI_NAP1L4_chr11_2985909_-_ATP11B_chr3_182631648_length(amino acids)=273AA_start in transcript=284_stop in transcript=1105
MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHD
LERKYAALYQPLFDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEY
DEPILKHLQDIKVKFSDPGQPMLTETNAGIKCLDSMCCFPEGEAACASVGRMLERVIGRCSPTHISRSWSASDPFYTNDRSILTLSTMDS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NAP1L4-ATP11B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NAP1L4-ATP11B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NAP1L4-ATP11B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNAP1L4C0001973Alcoholic Intoxication, Chronic1PSYGENET